2021/11/17 更新

写真a

ヨシムラ シンジ
吉村 信次
YOSHIMURA Shinji
所属
低温プラズマ科学研究センター プラズマ科学部門 特任准教授
職名
特任准教授

学位 1

  1. 博士(理学) ( 1998年3月   九州大学 ) 

 

論文 4

  1. Cold Atmospheric Plasma Modification of Amyloid β

    Yagi-Utsumi Maho, Tanaka Tomohiro, Otsubo Yoko, Yamashita Akira, Yoshimura Shinji, Nishida Motohiro, Kato Koichi

    International Journal of Molecular Sciences   22 巻 ( 6 ) 頁: 3116 - 3116   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Molecular Sciences  

    Cold atmospheric plasma (CAP) has attracted much attention in the fields of biotechnology and medicine owing to its potential utility in clinical applications. Recently accumulating evidence has demonstrated that CAP influences protein structures. However, there remain open questions regarding the molecular mechanisms behind the CAP-induced structural perturbations of biomacromolecules. Here, we investigated the potential effects of CAP irradiation of amyloid β (Aβ), an amyloidogenic protein associated with Alzheimer’s disease. Using nuclear magnetic resonance spectroscopy, we observed gradual spectral changes in Aβ after a 10 s CAP pretreatment, which also suppressed its fibril formation, as revealed by thioflavin T assay. As per mass spectrometric analyses, these effects were attributed to selective oxidation of the methionine residue (Met) at position 35. Interestingly, this modification occurred when Aβ was dissolved into a pre-irradiated buffer, indicating that some reactive species oxidize the Met residue. Our results strongly suggest that the H2O2 generated in the solution by CAP irradiation is responsible for Met oxidation, which inhibits Aβ amyloid formation. The findings of the present study provide fundamental insights into plasma biology, giving clues for developing novel applications of CAP.

    DOI: 10.3390/ijms22063116

    Web of Science

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    PubMed

  2. Insights into normothermic treatment with direct irradiation of atmospheric pressure plasma for biological applications

    Shinji Yoshimura, Yoko Otsubo, Akira Yamashita, Kenji Ishikawa

    Japanese Journal of Applied Physics   60 巻 ( 1 ) 頁: 010502 - 010502   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Journal of Applied Physics  

    Characterizing the interactions between plasma and living organisms has become a multidisciplinary topic in the field of low-temperature plasma science and technology. Living organisms are hierarchically comprised of cells, tissues, organs, and organ systems. Adaptive responses are systematically controlled by the state of the surrounding environment, such as when living organisms are irradiated with discharge plasma. This review is written from a biological perspective and focuses on the importance of gas temperature control in nonequilibrium atmospheric pressure plasmas. We discuss the critical parameters associated with direct plasma treatments of living organisms. This review provides an assessment of the status of this research field and addresses the prospects for further developments in understanding the interactions between plasma and living organisms. We address the importance and necessity of normothermic plasma treatment, where an experimental system involving living organisms is controlled at an optimal temperature, which plays a significant role in plasma biology.

    DOI: 10.35848/1347-4065/abcbd2

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    その他リンク: https://iopscience.iop.org/article/10.35848/1347-4065/abcbd2/pdf

  3. Modification of laser-induced fluorescence spectrum by additional azimuthal Doppler effect in optical vortex beams

    Shinji Yoshimura, Kenichiro Terasaka, Mitsutoshi Aramaki

    Japanese Journal of Applied Physics   59 巻   頁: SHHB04   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.35848/1347-4065/ab72cb

  4. Response of beam focusing to plasma fluctuation in a filament-arc-type negative ion source 査読有り

    Y. Haba, K. Nagaoka, K. Tsumori, M. Kisaki, K. Takahashi, H. Nakano, K. Ikeda, S. Yoshimura, M. Osakabe

    Japanese Journal of Applied Physics   59 巻 ( SH ) 頁: SHHA01-1 - SHHA01-5   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Journal of Applied Physics  

    Beam focusing is one of the most important elements for the stable and safe operation of high power negative ion beams, such as neutral beam injection into magnetically confined fusion plasmas. In order to investigate impacts of the source plasma fluctuation on beam focusing, a simultaneous measurement of the source plasma fluctuation and the beam current profile has been carried out in the research-and-development negative ion source at the National Institute for Fusion Science. The responses of beam width and of the beam centre deviation are observed for the first time, indicating the importance of the source plasma stability for the negative ion beam focusing.

    DOI: 10.35848/1347-4065/ab7473

    Web of Science

    Scopus