2021/10/22 更新

写真a

ハットリ ヒロユキ
服部 浩之
HATTORI Hiroyuki
所属
アジアサテライトキャンパス学院 国内教育部門 特任助教
大学院担当
大学院生命農学研究科
大学院生命農学研究科
職名
特任助教

学位 1

  1. 博士(農学) ( 2020年3月   岐阜大学 ) 

 

論文 4

  1. 6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise

    Hattori Hiroyuki, Mori Takashi, Shibata Takahiro, Kita Masaki, Mitsunaga Tohru

    MOLECULAR NUTRITION & FOOD RESEARCH   65 巻 ( 16 ) 頁: e2100185   2021年8月

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    記述言語:日本語   出版者・発行元:Molecular Nutrition and Food Research  

    Scope: Grains of Paradise (GOP), the seeds of Aframomum melegueta, has anti-obesity effects. However, the mechanisms underlying the effects remain unclear. Methods and Results: This study sets up to study the anti-obesity impact and homeostatic effects of 6-paradol, a major vanilloid found in GOP, and investigates the physiological outputs and the lipometabolism-related gene in fat and liver in high-fat-induced obese mice with a comparison with structurally similar vanilloids (6-gingerol and 6-shogaol). The vanilloids are synthesized in adequate quantities for performing animal experiments and orally administered to 6-week-old male mice over 2 weeks. This study found that 6-paradol decreased body weight gain and visceral and subcutaneous fats in 2 weeks, whereas 6-gingerol and 6-shogaol have no effect. Additionally, 6-paradol suppresses the hepatic cholesterol and triglyceride and significantly decreases the gene expression related to fatty acid synthesis, lipid transportation, and adipocyte differentiation in both liver and adipose tissue. Moreover, phosphorylation of AMP-activated protein kinase (AMPK) that greatly contributes to lipometabolism is promoted by 6-gingerol but not 6-paradol. Conclusion: These results suggest that 6-paradol regulates several obesity-related genes in an AMPK-independent manner. Therefore, it could be the principal active vanilloid in GOP giving it anti-obesity properties with a different mechanism.

    DOI: 10.1002/mnfr.202100185

    Web of Science

    Scopus

    PubMed

  2. Garcinoic Acids and a Benzophenone Derivative from the Seeds of Garcinia kola and Their Antibacterial Activities against Oral Bacterial Pathogenic Organisms

    Hioki Yusuke, Onwona-Agyeman Siaw, Kakumu Yuya, Hattori Hiroyuki, Yamauchi Kosei, Mitsunaga Tohru

    JOURNAL OF NATURAL PRODUCTS   83 巻 ( 7 ) 頁: 2087 - 2092   2020年7月

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    記述言語:日本語   出版者・発行元:Journal of Natural Products  

    In this study, three new garcinoic acid dimers, δ,δ-bigarcinoic acid (1), δ,δ-bi-O-garcinoic acid (2), and γ,δ-bi-O-garcinoic acid (3), and a new benzophenone derivative, (8E)-4-geranyl-3,5-dihydroxybenzophenone (4), as well as seven known compounds (5-11) were isolated from the seeds of Garcinia kola. The structures of the new compounds were elucidated using MALDI-TOF-MS and spectroscopic data, including 1D and 2D NMR and electronic circular dichroism spectra. All of the isolated compounds were evaluated for their antimicrobial activity against two oral pathogens, Porphyromonas gingivalis and Streptococcus sobrinus. Among them, 4 and δ-garcinoic acid (6) exhibited antimicrobial activity against both of these microorganisms (MICs of 31.3-62.5 μM for P. gingivalis and 15.6-31.3 μM for S. sobrinus). These results indicate that some chemical constituents in G. kola seeds have potential application in the prevention of oral diseases.

    DOI: 10.1021/acs.jnatprod.9b01045

    Web of Science

    Scopus

    PubMed

  3. Identification of vanilloid compounds in grains of paradise and their effects on sympathetic nerve activity.

    Hattori H, Yamauchi K, Onwona-Agyeman S, Mitsunaga T

    Journal of the science of food and agriculture   98 巻 ( 12 ) 頁: 4742 - 4748   2018年9月

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    記述言語:英語  

    DOI: 10.1002/jsfa.9009

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  4. Melanogenesis inhibitory activity of components from Salam leaf (Syzygium polyanthum) extract.

    Setyawati A, Hirabayashi K, Yamauchi K, Hattori H, Mitsunaga T, Batubara I, Heryanto R, Hashimoto H, Hotta M

    Journal of natural medicines   72 巻 ( 2 ) 頁: 474 - 480   2018年3月

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    記述言語:英語  

    DOI: 10.1007/s11418-018-1171-4

    PubMed

科研費 1

  1. 樹木系香辛料成分の抗肥満活性:作用点の違いから理解するバニロイドの機能的多様性

    研究課題/研究課題番号:21K14889  2021年4月 - 2023年3月

    科学研究費助成事業  若手研究

    服部 浩之

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    担当区分:研究代表者 

    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

    本研究では,香辛料Grains of Paradise (GOP) の示した肥満抑制作用の分子メカニズム解明を行う。これまで,申請者はGOPバニロイド成分が,トウガラシの主要な辛味バニロイドであるカプサイシンとは異なり,交感神経系を介さない経路により肥満抑制作用を示すことを発見した。この結果は,GOPバニロイド成分がカプサイシンとは異なる標的タンパク質との相互作用を介して肥満抑制作用を発現することを示唆している。したがって,GOPバニロイド成分に着目したケミカルバイオロジーおよび分子生物学的研究により,新たな肥満抑制機構の発見が期待できる。