Updated on 2022/03/31

写真a

 
YAMAMOTO Kenta
 
Organization
Nagoya University Hospital Diagnostic and Therapeutic Endoscopy Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 博士(医学) ( 2019.5   名古屋大学 ) 

Research Interests 4

  1. Hepatocellular carcinoma

  2. Gastroenterology

  3. Liver

  4. Microbiome

Research Areas 3

  1. Life Science / Gastroenterology  / Hepatology

  2. Others / Others  / Microbiome

  3. Life Science / Gastroenterology

Current Research Project and SDGs 1

  1. 腸内細菌叢を介した新たな治療開発による健康への貢献

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2014.4 - 2019.3

      More details

    Country: Japan

  2. Hamamatsu University School of Medicine   Faculty of Medicine

    2002.4 - 2008.3

      More details

    Country: Japan

Professional Memberships 6

  1. the Japan Gastroenterological Endoscopy Society

  2. the Japanese Society of Gastrointestinal Cancer Screening

  3. the Japan Society of Ultrasonics in Medicine

  4. The Japanese Society of Gastroenterology

  5. the Japan Society of Hepatology

  6. Japanese Society of Internal Medicine

▼display all

Awards 2

  1. JSGE-UEG Rising Stars

    2021.10   The Japanese Society of Gastroenterology   Focusing on the oral origin bacteria in the gut

     More details

    Award type:Award from international society, conference, symposium, etc.  Country:Austria

  2. Freiburg Rising Stars Academy

    2021.10   the University of Freiburg  

     More details

    Country:Germany

 

Papers 41

  1. Changes in the gut microbiome in relation to the degree of gastric mucosal atrophy before and after Helicobacter pylori eradication Reviewed

    Furune S, Yamamoto K, Honda T, Fujiyoshi T, Kakushima N, Furukawa K, Ohno E, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M.

    Scand J Gastroenterol   Vol. 57 ( 3 ) page: 266 - 273   2022.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00365521.2021.2005135

  2. Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver disease Reviewed

    Yamamoto K, Ishizu Y, Honda T, Ito T, Imai N, Nakamura M, Kawashima H, Kitaura Y, Ishigami M, Fujishiro M.

    Sci Rep   Vol. 12 ( 1 ) page: 3674   2022.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-07810-3

  3. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients Reviewed

    Nakamura M, Maeda K, Yamamoto K, Yamamura T, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Ishigami M, Kawashima H.

    Digestion     page: 1 - 12   2022.2

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000521929

  4. Changes in the gut microbiota after hepatitis C virus eradication Reviewed

    Honda T, Ishigami M, Yamamoto K, Takeyama T, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Miyahara R, Ishikawa T, Hirooka Y, Fujishiro M.

    Sci Rep   Vol. 11 ( 1 ) page: 23568   2021.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-03009-0

  5. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency Reviewed

    Uetsuki K, Kawashima H, Ohno E, Ishikawa T, Iida T, Yamamoto K, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Fujishiro M

    BMC gastroenterology   Vol. 21 ( 1 ) page: 211   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-021-01776-8

  6. Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine Reviewed

    Kenta Yamamoto Takashi Honda Shinya Yokoyama Lingyun Asuka Kato Takanori Ito Yoji Ishizu Teiji Kuzuya Masanao Nakamura Hiroki Kawashima Masatoshi Ishigami Noriko M.Tsuji Mitsuhiro Fujishiro

    Digestive and Liver Disease     2021

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.dld.2021.02.013

  7. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis. Reviewed

    Muto H, Ito T, Tanaka T, Yokoyama S, Yamamoto K, Imai N, Ishizu Y, Maeda K, Honda T, Ishikawa T, Kato A, Ohshiro T, Kano F, Yamamoto A, Sakai K, Hibi H, Ishigami M, Fujishiro M

    Scientific reports.   Vol. 11 ( 1 ) page: 18778   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  8. The microbiome can predict mucosal healing in small intestine in patients with Crohn’s disease Reviewed

    Shun Hattori, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Kenta Yamamoto, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Masatoshi Ishigami, Yoshiki Hirooka Mitsuhiro Fujishiro

    Journal of gastroenterology   Vol. 55 ( 12 ) page: 1138 - 1149   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  9. The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis C Reviewed

    Kenta Yamamoto , Takashi Honda , Takanori Ito , Yoji Ishizu , Teiji Kuzuya , Masanao Nakamura , Ryoji Miyahara , Hiroki Kawashima , Masatoshi Ishigami , Mitsuhiro Fujishiro

    Journal of Gastroenterology and Hepatology     2020.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.15206

  10. Relationship between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib Reviewed

    Yamamoto, Kenta, Teiji Kuzuya, Takashi Honda, Takanori Ito, Yoji Ishizu, Masanao Nakamura, Ryoji Miyahara, Hiroki Kawashima, Masatoshi Ishigami, and Mitsuhiro Fujishiro

    Anticancer Research   Vol. 40 ( 2 ) page: 665–76   2020

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. Microbiota Profile Is Different for Early and Invasive Colorectal Cancer and Is Consistent throughout the Colon. Reviewed

    Zorron Cheng Tao Pu, Leonardo, Kenta Yamamoto, Takashi Honda, Masanao Nakamura, Takeshi Yamamura, Shun Hattori, Alastair D. Burt, Rajvinder Singh, Yoshiki Hirooka, and Mitsuhiro Fujishiro.

    Journal of Gastroenterology and Hepatology   Vol. 35 ( 3 ) page: 433–37   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  12. Influence of Proton Pump Inhibitors on Microbiota in Chronic Liver Disease Patients. Reviewed

    Yamamoto, Kenta, Masatoshi Ishigami, Takashi Honda, Tomoaki Takeyama, Takanori Ito, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Hidemi Goto, and Yoshiki Hirooka.

    Hepatology International   Vol. 13 ( 2 ) page: 234–44   2019

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  13. Changes in Body Composition Predict the Time to Treatment Failure of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma: A Pilot Retrospective Study Reviewed

    Yamamoto T, Imai N, Kuzuya T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M.

    Nutr Cancer     page: 1 - 10   2022.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/01635581.2022.2049322

  14. Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosis Reviewed

    Sugiyama Y, Ishizu Y, Ando Y, Yokoyama S, Yamamoto K, Ito T, Imai N, Nakamura M, Honda T, Kawashima H, Ishikawa T, Ishigami M.

    Eur J Gastroenterol Hepatol   Vol. 33 ( S1 ) page: :e916 - e921   2021.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MEG.0000000000002303

  15. Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes. Reviewed

    Norihiro Imai, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami

    Anticancer research   Vol. 41 ( 11 ) page: 5817 - 5820   2021.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.15399.

  16. Absence of large portal collateral vessels is associated with spontaneous improvement of cirrhotic portal vein thrombosis Reviewed

    Shinya Yokoyama, Yoji Ishizu 1, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Tomoyuki Tsuzuki, Masatoshi Ishigami

    Hepatology research : the official journal of the Japan Society of Hepatology     2021.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13725.

  17. Immune-related liver injury is a poor prognostic factor in patients with non-small cell lung cancer treated with immune checkpoint inhibitors Reviewed

    Takafumi Yamamoto, Takanori Ito, Tetsunari Hase, Masatoshi Ishigami, Kazuyuki Mizuno, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Hirofumi Shibata, Takahiro Hatta, Naoyuki Yogo, Satoshi Yasuda, Hidenori Toyoda, Takashi Abe, Hiroki Kawashima, Naozumi Hashimoto, Mitsuhiro Fujishiro

    Cancer investigation     2021.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/07357907.2021.1994586.

  18. The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophilia: HCC after HCV eradication in hemophilia. Reviewed

    Inukai Y, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M

    Annals of hepatology     2021.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.aohep.2021.100545

  19. Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated Complications. Reviewed

    Ishigami M, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Kamei H, Ogura Y, Fujishiro M

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation   Vol. 19 ( 9 ) page: 935 - 942   2021.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  20. Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies Reviewed

    Ito T, Ishigami M, Yamamoto T, Mizuno K, Yamamoto K, Imai N, Ishizu Y, Honda T, Kawashima H, Yasuda S, Toyoda H, Yokota K, Hase T, Nishio N, Maeda O, Kato M, Hashimoto N, Hibi H, Kodera Y, Sone M, Ando Y, Akiyama M, Shimoyama Y, Fujishiro M

    Hepatology international     2021.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12072-021-10238-y

  21. Quality of Life in patients with nonalcoholic fatty liver disease: Structure and related factors focusing on illness uncertainty. Reviewed

    Naoki Ozawa Kazuki Sato Ayumi Sugimura Shigeyoshi Maki Taku Tanaka Kenta Yamamoto Takanori Ito Yoji Ishizu Teiji Kuzuya Takashi Honda Masatoshi Ishigami Mitsuhiro Fujishiro Tetsuya Ishikawa Shoko Ando

    Japan journal of nursing science     2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jjns.12415

  22. Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma Reviewed

    NORITAKA MATSUDA, NORIHIRO IMAI, TEIJI KUZUYA, KENTA YAMAMOTO, TAKANORI ITO, YOJI ISHIZU, TAKASHI HONDA, MASATOSHI ISHIGAMI and MITSUHIRO FUJISHIRO

    In vivo.   Vol. 35 ( 2 ) page: 1185 - 1189   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/invivo.12367

  23. Impact of visceral fat accumulation on the prognosis of patients with cirrhosis Reviewed

    Yoji Ishizu Masatoshi Ishigami Takashi Honda Norihiro Imai Takanori Ito Kenta Yamamoto Mitsuhiro Fujishiro

    Clinical Nutrition ESPEN     2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.clnesp.2021.01.008

  24. Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia Reviewed

    Takafumi Yamamoto Norihiro Imai Kenta Yamamoto Takanori Ito Yoji Ishizu Takashi Honda Shuichi Okamoto Takeshi Kanematsu Nobuaki Suzuki Tadashi Matsushita Masatoshi Ishigami Mitsuhiro Fujishiro

    Haemophilia   Vol. 27 ( 1 ) page: 100 - 107   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hae.14220

  25. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs Reviewed

    Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M.

    Anticancer research   Vol. 40 ( 5 ) page: 2569 - 2573   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.15035

  26. The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC Reviewed

    Ito T, Ishigami M, Morooka H, Yamamoto K, Imai N, Ishizu Y, Honda T,Nishimura D, Tada T, Yasuda S, Toyoda H, Kumada T, Fujishiro

    Scientific reports.   Vol. 10 ( 1 ) page: 17812   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-74732-3

  27. Antifibrotic Effects of 1,25(OH)2D3 on Nonalcoholic Steatohepatitis in Female Mice.

    Ma, Lingyun, Masatoshi Ishigami, Takashi Honda, Shinya Yokoyama, Kenta Yamamoto, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Yoshiki Hirooka, and Hidemi Goto.

    Digestive Diseases and Sciences   Vol. 64 ( 9 ) page: 2581–90   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  28. この症例に学ぶ 体外式腹部超音波検査にて描出しえた早期胃癌の一例 Invited Reviewed

    山本 健太, 熊田 卓, 久永 康宏, 金森 明, 多田 俊史, 北畠 秀介, 曽根 康博

    日本消化器がん検診学会雑誌   Vol. 52 ( 3 ) page: 387-392   2014.5

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  29. 術中色素動注法が切除範囲決定に有用であった小腸angioectasiaの1例(原著論文/症例報告) Reviewed

    山本 健太, 熊田 卓, 桐山 勢生, 谷川 誠, 久永 康宏, 豊田 秀徳, 金森 明, 多田 俊史, 北畠 秀介, 曽根 康博

    日本消化器病学会雑誌   Vol. 111 ( 4 ) page: 773-778   2014.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  30. 肝細胞癌と鑑別が困難であったreactive lymphoid hyperplasiaの1例 Reviewed

    山本 健太, 熊田 卓, 桐山 勢生, 谷川 誠, 久永 康宏, 豊田 秀徳, 金森 明, 多田 俊史, 北畠 秀介, 長谷川 綾平, 伊藤 隆徳, 安藤 祐資, 颯田 祐介, 田中 達也, 曽根 康博, 福里 利夫

    肝臓   Vol. 54 ( 11 ) page: 755-764   2013.11

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  31. 腹腔鏡下胆嚢摘出術後13年目に生じた金属クリップを核とした胆管結石の1例 Reviewed

    山本 健太, 金森 明, 桐山 勢生, 谷川 誠, 久永 康宏, 豊田 秀徳, 多田 俊史, 安東 直人, 新家 卓郎, 坂井 圭介, 安田 諭, 安藤 祐資, 木村 純, 曽根 康博, 熊田 卓

    日本消化器内視鏡学会雑誌   Vol. 55 ( 5 ) page: 1667-1672   2013.5

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  32. Oral supplementation with branched-chain amino acid granules prevents hepatocarcinogenesis in patients with hepatitis C-related cirrhosis: A propensity score analysis Reviewed

    Toshifumi Tada Takashi Kumada Hidenori Toyoda Seiki Kiriyama Makoto Tanikawa Yasuhiro Hisanaga Akira Kanamori Shusuke Kitabatake Takuro Niinomi Takanori Ito Ryohei Hasegawa Yusuke Ando Kenta Yamamoto Tatsuya Tanaka

    Hepatology research   Vol. 44 ( 3 ) page: 288 - 295   2013.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  33. Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients Reviewed

    Kumada T, Toyoda H, Tada T, Kiriyama S, Tanikawa M, Hisanaga Y, Kanamori A, Niinomi T, Yasuda S, Andou Y, Yamamoto K, Tanaka J

    Journal of Hepatology   Vol. 58 ( 3 ) page: 427-33   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  34. 肝切除を基本とした肝細胞癌の治療戦略 Invited Reviewed

    多田 俊史, 熊田 卓, 桐山 勢生, 谷川 誠, 久永 康宏, 豊田 秀徳, 金森 明, 新家 卓郎, 長谷川 綾平, 伊藤 隆徳, 安田 諭, 安藤 祐資, 山本 健太, 田中 達也

    消化器内科   Vol. 55 ( 5 ) page: 612-616   2012.11

     More details

    Language:Japanese  

  35. この画像から何が読めるか? 肝腫瘤(図説) Invited Reviewed

    山本 健太, 熊田 卓, 豊田 秀徳, 多田 俊史

    肝胆膵画像   Vol. 14 ( 6 ) page: 542-545   2012.9

     More details

    Authorship:Lead author   Language:Japanese  

  36. B型肝炎に対する核酸アナログ投与例の長期予後 Invited Reviewed

    多田 俊史, 熊田 卓, 桐山 勢生, 谷川 誠, 豊田 秀徳, 久永 康宏, 金森 明, 新家 卓郎, 安東 直人, 坂井 圭介, 安田 諭, 木村 純, 安藤 祐資, 山本 健太

    消化器内科   Vol. 54 ( 5 ) page: 608-613   2012.5

     More details

    Language:Japanese  

  37. FOLFIRI+Panitumumab療法中に発症した薬剤性肺障害に対してステロイド・パルス療法が奏効したS状結腸癌の1例 Reviewed

    山本 健太, 加藤 俊夫, 進藤 丈, 安藤 守秀, 安部 崇, 白木 晶, 中島 治典, 雪田 洋介

    癌と化学療法   Vol. 53 ( 3 ) page: 326-330   2011.9

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  38. 肝発癌を視野に入れたB型肝炎の治療戦略 Invited Reviewed

    坂井 圭介, 熊田 卓, 豊田 秀徳, 桐山 勢生, 谷川 誠, 久永 康宏, 金森 明, 多田 俊史, 新家 卓郎, 安東 直人, 安田 諭, 安藤 祐資, 山本 健太, 木村 純

    消化器内科   Vol. 53 ( 3 ) page: 326-330   2011.9

     More details

    Language:Japanese  

  39. 特異な形態を示し経カテーテル的動脈塞栓術を施行した膵十二指腸動脈瘤破裂の1例 Reviewed

    山本 健太, 熊田 卓, 桐山 勢生, 谷川 誠, 久永 康宏, 豊田 秀徳, 金森 明, 多田 俊史, 荒川 恭宏, 藤森 将志, 新家 卓郎, 安東 直人

    胆道   Vol. 24 ( 4 ) page: 603-610   2010.10

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  40. コイン型リチウム電池誤飲により食道潰瘍を来した2例 後遺症を残さなかった1例と後遺症を残した1例 Reviewed

    山本 健太, 岩田 晶子, 都間 佑介, 田中 龍一, 山本 崇裕, 永田 智子, 伊藤 貴美子, 鹿野 博明, 中嶋 義記, 近藤 富雄

    小児科臨床   Vol. 63 ( 7 ) page: 1667-1673   2010.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  41. 造影超音波検査で特徴的な所見が得られた肝細胞腺腫の1例 Reviewed

    山本 健太, 熊田 卓, 桐山 勢生, 曽根 康博, 谷川 誠, 久永 康宏, 豊田 秀徳, 金森 明, 渥美 裕之, 高木 万起子, 中野 聡, 荒川 恭宏, 藤森 将志, 高橋 健一, 竹島 賢治, 乙部 克彦

    肝胆膵画像   Vol. 11 ( 5 ) page: 564-570   2009.9

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

▼display all

Books 1

  1. 消化器内科専攻医マニュアル

    名古屋大学消化器内科( Role: Joint author)

    ㈱シービーアール  2022.2  ( ISBN:4908083738

     More details

    Total pages:636   Responsible for pages:9   Language:Japanese Book type:Textbook, survey, introduction

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. ネットワーク解析を用いた腸内細菌が合成するアミノ酸と肝硬変・筋肉量の関連性の解明

    Grant number:21K15970  2021.4 - 2024.3

    日本学術振興会  科学研究費  若手研究

    山本 健太

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    肝硬変患者における腸内細菌叢が作るアミノ酸と筋肉量の関連性を明確にし、有用もしくは有害な細菌を同定することでサルコペニアや肝性脳症のリスク評価を可能とするバイオマーカーの発見と治療・予防薬の開発を目指す。肝硬変患者ではアンモニア産生菌や分岐鎖アミノ酸以外のアミノ酸合成菌が多く、アミノ酸を生成する際に窒素をとりあう「細菌による競合」が生じている可能性がある。この解明には単一の細菌を検出する目的ではなく肝硬変による腸内細菌叢の乱れ、競合する細菌など複数の有用な細菌や競合する細菌のネットワークを明らかにすることで新たな視点により人体に与える影響を解明する。

  2. サルコペニア患者に対する腸内細菌叢への介入による効果的な運動療法の開発

    Grant number:21K11261  2104.1

    日本学術振興会  科学研究費  基盤研究(C)

    石津 洋二,本多 隆 ,梅垣 宏行

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )