Faculty Profiles - IMAI Norihiro

Papers - IMAI Norihiro

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Successful Treatment with Steroids in a Patient with Vanishing Bile Duct Syndrome and Acute Tubular Necrosis.

Fumitaka Mizuno, Norihiro Imai, Kazushi Yasuda, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima

Internal medicine (Tokyo, Japan) Vol. 63 ( 1 ) page： 57 - 61 2024

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

Vanishing bile duct syndrome (VBDS) is a rare but potentially serious cholestatic liver disease caused by various etiologies, including drugs. We herein report a complicated case of VBDS with acute tubular necrosis (ATN) that improved significantly with steroid treatment. An Asian man in his 30s was admitted with the acute onset of severe jaundice and a decline in the renal function. Although initial treatment with ursodeoxycholic acid did not reduce jaundice or renal dysfunction, steroid treatment remarkably improved the VBDS and ATN to within the respective normal ranges. Steroid treatment can be considered in cases of VBDS that appear to have an immune-mediated cause.

DOI： 10.2169/internalmedicine.1826-23

当院における免疫チェックポイント阻害薬投与によるHBV再活性化リスクの検討

水野和幸, 伊藤隆徳, 山本崇文, 横山晋也, 山本健太, 今井則博, 石津洋二, 本多隆, 石上雅敏, 川嶋啓揮

日本消化器病学会雑誌 Vol. 120 ( 臨増総会 ) page： A309 - A309 2023.3

Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescents. International journal

Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Akinari Hinoki, Wataru Sumida, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Kazuki Yokota, Hiroo Uchida, Masatoshi Ishigami

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie Vol. 30 ( 2 ) page： 109 - 112 2023.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Like esophageal varices, cardiac varices are often treated with endoscopic variceal ligation (EVL). However, we previously reported that EVL for cardiac varices may be associated with a high risk of rebleeding from the ulcer if the O-ring spontaneously drops off early. The efficacy and safety of para-variceal endoscopic injection sclerotherapy (EIS) with polidocanol for the treatment of cardiac varices in children and adolescents were evaluated. METHODS: Eleven patients under 18 years of age with portal hypertension who underwent para-variceal EIS with polidocanol for cardiac varices with red signs, which were considered to be at high risk of bleeding, were retrospectively reviewed. RESULTS: One session of para-variceal polidocanol-EIS was performed for each of the 11 patients. One patient experienced temporary hypoxia due to aspiration of saliva when the tracheal intubation tube was removed after the procedure but recovered by endotracheal suctioning; there were no other adverse events. In six of the eight cases in which efficacy could be evaluated, eradication of cardiac varices was achieved. CONCLUSION: Para-variceal polidocanol-EIS may be considered instead of EVL for small cardiac varices with red signs in pediatric patients with cardiac varices.

DOI： 10.1016/j.arcped.2022.11.016

Decreased appetite is associated with the presence of sarcopenia in patients with cirrhosis. International journal

Yoji Ishizu, Masatoshi Ishigami, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Shinya Yokoyama, Tetsuya Ishikawa, Hiroki Kawashima

Nutrition (Burbank, Los Angeles County, Calif.) Vol. 103 page： 111807 - 111807 2022.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To our knowledge, the relationship between appetite and sarcopenia in patients with cirrhosis is unknown. The aims of this study were to examine the factors associated with decreased appetite and to clarify the relationship between appetite and sarcopenia. METHODS: This study included 61 patients with cirrhosis. The patients were asked to describe their appetite using a numerical rating scale (NRS) from 0 (none at all) to 10 (most), with ≤5 defined as decreased appetite. The clinical characteristics, gastrointestinal symptoms as assessed using the Gastrointestinal Symptom Rating Scale, handgrip strength, and skeletal muscle area at the third vertebra were collected retrospectively. Sarcopenia was diagnosed according to the criteria of the Japan Society of Hepatology. The differences in these factors between patients with and without decreased appetite, and the factors associated with the presence of sarcopenia were examined. RESULTS: Alcoholic liver disease was the most common etiology. The median Model for End-Stage Liver Disease score was 8 (interquartile range = 7 - 10) and hepatocellular carcinoma was present in 35 patients. Overall, 36% of the patients with cirrhosis had decreased appetite. Patients with decreased appetite had a higher frequency of abdominal pain and acid reflux-related symptoms and significantly lower handgrip strength than patients without, among both men (P = 0.034) and women (P = 0.017). The multivariate analysis identified a decrease in appetite as a significant factor associated with the presence of sarcopenia (NRS one increase, odds ratio, 0.701; 95% confidence interval, 0.502-0.977; P = 0.036). CONCLUSION: Decreased appetite was associated with the presence of sarcopenia.

DOI： 10.1016/j.nut.2022.111807

Factors associated with the progression of myosteatosis in patients with cirrhosis. International journal

Yoji Ishizu, Masatoshi Ishigami, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Shinya Yokoyama, Tetsuya Ishikawa, Mitsuhiro Fujishiro

Nutrition (Burbank, Los Angeles County, Calif.) Vol. 103 page： 111777 - 111777 2022.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: The presence of myosteatosis is one factor associated with poor prognosis for patients with cirrhosis; however, the factors contributing to worsening myosteatosis are, to our knowledge, unknown. The aim of this study was to clarify the changes in myosteatosis, and the factors involved in these changes. METHODS: The present study enrolled 178 patients with cirrhosis who underwent computed tomography twice to measure changes in skeletal muscle attenuation (SMA) at the L3 level. Factors associated with SMA and those associated with changes in SMA were examined. RESULTS: Using linear multiple regression analysis, age (β = -0.22), skeletal muscle index (SMI; skeletal muscle area divided by height squared; β = 0.25), and visceral and subcutaneous fat indices (VFI and SFI; the visceral and subcutaneous fat areas at the umbilical level divided by height squared; β = -0.08, β = -0.06, respectively) were identified as associated with SMA. The 100-d change in SMA was -0.21 ± 1.29 Hounsfield units (HU). Changes in SMI and SMA were positively associated (R = 0.183, P = 0.014), whereas those in VFI and SMA were negatively associated (R = -0.172, P = 0.022). No association was noted between the 100-d changes in SFI and SMA. In patients whose SMI increased and VFI decreased, the 100-d change in SMA was 0.24 ± 1.82 HU, which was marginally different from that in patients whose SMI decreased and VFI increased (-0.44 ± 1.32 HU, P = 0.077). CONCLUSIONS: In patients with cirrhosis, myosteatosis progressed, and decreases in SMI and increases in VFI were correlated with its progression.

DOI： 10.1016/j.nut.2022.111777

Effectiveness of Porous Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Solitary Hepatocellular Carcinoma. International journal

Norihiro Imai, Masatoshi Ishigami, Yumi Oie, Motoki Kumagai, Yosuke Inukai, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Hiroki Kawashima

Anticancer research Vol. 42 ( 8 ) page： 3947 - 3951 2022.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: A porous glass membrane-pumping emulsification device (GMD) enables the formation of a high-percentage water-in-oil emulsion with homogeneous and stable droplets. Although GMD is expected to improve the locoregional therapeutic effects of transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC), its effectiveness in the management of solitary HCC remains unclear. PATIENTS AND METHODS: Patients treated for solitary HCCs (<5 cm) were retrospectively reviewed. A total of 46 patients who could not undergo liver resection and were unsuitable for radiofrequency ablation were included in this study. Among these, 22 patients underwent TACE using a GMD (GMD-TACE group) and 24 underwent stereotactic body radiotherapy (SBRT) using a robotic radiosurgery system (SBRT group). Local control rates were compared between the two groups. RESULTS: The median HCC tumour size was 24 mm (range=12-50 mm) and 22 mm (range=8-39 mm) in the GMD-TACE and SBRT groups, respectively; however, the difference between the groups was not significant. Age, liver function test results, or Child-Pugh scores were not significantly different between the two groups. The rate of local control at 6 months after treatment was 100% in both groups. Although the 1-year local control rate was higher in the SBRT group (92.3%) than in the GMD-TACE group (81.8%), there was no significant difference in the log-rank test (p=0.654). No major treatment-related complications occurred in either group during the observation period. CONCLUSION: TACE with GMD could be considered an effective treatment option for the management of solitary HCC.

DOI： 10.21873/anticanres.15889

A case of antiprogrammed death-ligand 1 antibody-induced multisystem immune-related adverse events with pancreatitis and steroid-resistant sclerosing cholangitis. International journal

Takafumi Yamamoto, Takanori Ito, Kazuyuki Mizuno, Yokoyama Shinya, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Hiroki Kawashima, Toshinori Matsui, Tetsunari Hase, Naozumi Hashimoto, Masatoshi Ishigami

Journal of digestive diseases Vol. 23 ( 7 ) page： 404 - 409 2022.7

非小細胞肺癌に対する抗Programmed Death-Ligand 1抗体治療で発症した免疫関連硬化性胆管炎の1例

山本崇文, 伊藤隆徳, 松田宜賢, 犬飼庸介, 杉山由晃, 吉岡直輝, 水野和幸, 武藤久哲, 横山晋也, 山本健太, 今井則博, 石津洋二, 本多隆, 石上雅敏

日本消化器病学会東海支部例会プログラム抄録集 Vol. 136回 page： 56 - 56 2022.5

肝硬変患者の予後予測における脂肪成分の少ない骨格筋を用いた骨格筋量の有用性

石津洋二, 松田宜賢, 犬飼庸介, 山本崇文, 杉山由晃, 水野和幸, 吉岡直輝, 武藤久哲, 横山晋也, 山本健太, 伊藤隆徳, 今井則博, 本多隆, 石上雅敏

肝臓 Vol. 63 ( Suppl.1 ) page： A348 - A348 2022.4

肝疾患における核内脂肪滴の2つの異なる役割

今井則博, 横山晋也, 山本健太, 伊藤隆徳, 石津洋二, 本多隆, 石上雅敏

肝臓 Vol. 63 ( Suppl.1 ) page： A354 - A354 2022.4

肝硬変患者における質を考慮したより適切な骨格筋量評価の提案

杉山由晃, 石津洋二, 山本崇文, 犬飼庸介, 吉岡直輝, 水野和幸, 武藤久哲, 横山晋也, 山本健太, 伊藤隆徳, 今井則博, 本多隆, 石上雅敏, 藤城光弘

肝臓 Vol. 62 ( Suppl.2 ) page： A576 - A576 2021.9

Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs.

Yamamoto T, Imai N, Yamamoto K, Ito T, Ishizu Y, Honda T, Okamoto S, Kanematsu T, Suzuki N, Matsushita T, Ishigami M, Fujishiro M

Anticancer research Vol. 41 ( 5 ) page： 2569 - 2573 2021.5

Impact of visceral fat accumulation on the prognosis of patients with cirrhosis

Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Fujishiro Mitsuhiro

CLINICAL NUTRITION ESPEN Vol. 42 page： 354 - 360 2021.4

核酸アナログ治療中止可能予測因子とHBVコア変異の関係

本多隆, 石上雅敏, 山本崇文, 犬飼庸介, 杉山由晃, 吉岡直輝, 水野和幸, 武藤久哲, 横山晋也, 山本健太, 伊藤隆徳, 今井則博, 石津洋二, 石川哲也, 藤城光弘

肝臓 Vol. 62 ( Suppl.1 ) page： A344 - A344 2021.4

Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma.

Matsuda N, Imai N, Kuzuya T, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Fujishiro M

In vivo (Athens, Greece) Vol. 35 ( 2 ) page： 1185 - 1189 2021.3

Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia

Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

HAEMOPHILIA Vol. 27 ( 1 ) page： 100 - 107 2021.1

The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC

Ito Takanori, Ishigami Masatoshi, Morooka Hikaru, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Nishimura Daisaku, Tada Toshifumi, Yasuda Satoshi, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 17812 2020.10

Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

Tillman Matthew C., Imai Norihiro, Li Yue, Khadka Manoj, Okafor C. Denise, Juneja Puneet, Adhiyaman Akshitha, Hagen Susan J., Cohen David E., Ortlund Eric A.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 117 ( 36 ) page： 22080 - 22089 2020.9

Them1 Binds to Free Fatty Acids and is Allosterically Regulated by Lysophosphatidylcholine to Control Fatty Acyl-CoA Hydrolysis in Brown Adipose Tissue

Tillman Matthew, Li Yue, Khadka Manoj, Imai Norihiro, Adhiyaman Akshitha, Juneja Puneet, Hagen Susan, Cohen David, Ortlund Eric

FASEB JOURNAL Vol. 34 2020.4

Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolic Activity in Brown Adipose Tissue

Li Yue, Imai Norihiro, Goyal Samaksh, Nicholls Hayley, Krisko Tibor, Baqai Mahnoor, Ang Lay-Hong, Tillman Matthew, Ortlund Eric, Cohen David, Hagen Susan

FASEB JOURNAL Vol. 34 2020.4

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