Updated on 2022/04/15

写真a

 
KOBAYASHI Masumi
 
Organization
Nagoya University Hospital Otorhinolaryngology Assistant Professor
Title
Assistant Professor

Degree 2

  1. 博士(医学) ( 2022.3   名古屋大学 ) 

  2. 学士(医学) ( 2013.3   名古屋大学 ) 

 

Papers 20

  1. Labyrinthitis With Endolymphatic Hydrops Revealed by Imaging Analysis in a Case With Severe Postoperative Complications Following Stapes Surgery Reviewed

    Kobayashi Masumi, Yoshida Tadao, Uchida Yasue, Sugimoto Satofumi, Naganawa Shinji, Sone Michihiko

    OTOLOGY & NEUROTOLOGY   Vol. 43 ( 1 ) page: E134 - E136   2022.1

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    Language:Japanese   Publisher:Otology and Neurotology  

    DOI: 10.1097/MAO.0000000000003328

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  2. 軟骨伝導補聴器に対する東海地方の助成状況と経過

    杉本 賢文, 福永 有可里, 水野 知美, 原 大介, 小林 万純, 吉田 忠雄, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 64 ( 5 ) page: 489 - 489   2021.9

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    Language:Japanese   Publisher:一般社団法人 日本聴覚医学会  

    DOI: 10.4295/audiology.64.489

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  3. めまい症状から高度難聴に至った多発性硬化症再発例

    小林 万純, 杉本 賢文, 吉田 忠雄, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 64 ( 5 ) page: 391 - 391   2021.9

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    Language:Japanese   Publisher:一般社団法人 日本聴覚医学会  

    DOI: 10.4295/audiology.64.391

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  4. Evaluation of the blood–perilymph barrier in ears with endolymphatic hydrops

    Yoshida Tadao, Kobayashi Masumi, Sugimoto Satofumi, Teranishi Masaaki, Naganawa Shinji, Sone Michihiko

    Acta Oto-Laryngologica   Vol. 141 ( 8 ) page: 736 - 741   2021.8

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    Background: Otological diseases including Meniere’s disease (MD) involve endolymphatic hydrops (EH), which can be visualized by magnetic resonance imaging (MRI) with gadolinium contrast agents, but the temporal changes of contrast in the inner ear have not been evaluated. Objectives: We investigated the permeability of the blood–perilymph barrier (BPB) in ears with EH to evaluate the severity of the inner ear disturbances. Materials and methods: The study included 32 ears from 16 patients with EH or related diseases who underwent MRI. The permeability of the BPB was assessed by the signal–intensity ratio (SIR) at four-time points: before and at 10 min, 4 h, and 24 h after administration of gadolinium for assessing EH. Results: Cochlear EH was found in 25 of the 32 ears, and vestibular EH in 11. The rate of EH was significantly higher in symptomatic ears; however, the existence of EH was not related to SIR values. Nevertheless, SIR values in the basal turn were significantly higher 4 and 24 h after injection of gadolinium in patients aged ≥50 years. Conclusion and significance: Higher SIR values observed in older patients with EH indicate severe disturbances of the BPB in the cochlea, which may account for intractable inner ear disturbances in older patients.

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  5. Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops Reviewed

    Yoshida Tadao, Kobayashi Masumi, Sugimoto Satofumi, Teranishi Masaaki, Naganawa Shinji, Sone Michihiko

    ACTA OTO-LARYNGOLOGICA   Vol. 141 ( 8 ) page: 736 - 741   2021.8

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    Language:Japanese   Publisher:Acta Oto-Laryngologica  

    Background: Otological diseases including Meniere’s disease (MD) involve endolymphatic hydrops (EH), which can be visualized by magnetic resonance imaging (MRI) with gadolinium contrast agents, but the temporal changes of contrast in the inner ear have not been evaluated. Objectives: We investigated the permeability of the blood–perilymph barrier (BPB) in ears with EH to evaluate the severity of the inner ear disturbances. Materials and methods: The study included 32 ears from 16 patients with EH or related diseases who underwent MRI. The permeability of the BPB was assessed by the signal–intensity ratio (SIR) at four-time points: before and at 10 min, 4 h, and 24 h after administration of gadolinium for assessing EH. Results: Cochlear EH was found in 25 of the 32 ears, and vestibular EH in 11. The rate of EH was significantly higher in symptomatic ears; however, the existence of EH was not related to SIR values. Nevertheless, SIR values in the basal turn were significantly higher 4 and 24 h after injection of gadolinium in patients aged ≥50 years. Conclusion and significance: Higher SIR values observed in older patients with EH indicate severe disturbances of the BPB in the cochlea, which may account for intractable inner ear disturbances in older patients.

    DOI: 10.1080/00016489.2021.1957500

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  6. Dilatation of the Endolymphatic Space in the Ampulla of the Posterior Semicircular Canal: A New Clinical Finding Detected on Magnetic Resonance Imaging

    Morioka Masaru, Sugimoto Satofumi, Yoshida Tadao, Teranishi Masaaki, Kobayashi Masumi, Nishio Naoki, Katayama Naomi, Naganawa Shinji, Sone Michihiko

    Otology & Neurotology   Vol. 42 ( 6 ) page: e643 - e647   2021.7

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    Objectives: To investigate the clinical features of ears with dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal on magnetic resonance imaging. Study Design: Retrospective study. Setting: A university hospital. Methods: This study included 1,842 ears from 934 patients who underwent 3-T magnetic resonance imaging with gadolinium to investigate the presence of endolymphatic hydrops. Age, sex distribution, hearing thresholds on pure-tone audiometry, and vestibular symptoms were compared between cases of unilateral and bilateral dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal. Results: Forty-eight ears (17 men and 14 women; mean age 49.9 yrs) showed dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal. Age and the rate of chronic sensorineural hearing loss were significantly higher in the unilateral group (14 ears) than in the bilateral group (34 ears). The average hearing thresholds and rates of vestibular symptoms reported did not differ between unilateral and bilateral cases, but some patients showed positional nystagmus. Conclusions: Dilatation of the endolymphatic space in the ampulla was observed selectively in the posterior semicircular canal, though its pathogenesis was not clear. Such dilatation is not usually accompanied by vestibular endolymphatic hydrops, and it may be a cause of vertigo and dizziness.

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  7. Cochlear implantation in patient with Charcot-Marie-Tooth disease

    Kobayashi Masumi, Yoshida Tadao, Sugimoto Satofumi, Teranishi Masaaki, Hara Daisuke, Kimata Yukari, Sone Michihiko

    Auris Nasus Larynx   Vol. 48 ( 2 ) page: 327 - 330   2021.4

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    Two patients with auditory neuropathy spectrum disorder (ANSD) considered to be associated with Charcot-Marie-Tooth (CMT) are reported. In case 1, a 23-year-old man presented with progressive bilateral sensorineural hearing loss (SNHL) from 10 years of age and was diagnosed with ANSD. He was later diagnosed with CMT by neurological testing. In case 2, a 16-year-old girl, the younger sister of the patient in case 1, presented with progressive SNHL with similar auditory findings since 6 years of age as those of her brother. Both cases underwent bilateral cochlear implantation. In case 1, the maximum discrimination score improved to 45% 24 months after the first side of cochlear implantation from 5% before the surgery. In case 2, the score was 5% 10 months after cochlear implant (CI) surgery from 0% before the surgery. CI treatment for CMT patients has been considered difficult because of both failure in synchronization of nerve conduction due to demyelination and axonal failure of the auditory nerve. Though slower progress compared to the average subset of patients receiving CI was seen, significant improvement was gradually observed in the present patients after bilateral cochlear implantations. CI is thus a viable option for rehabilitation of SNHL in CMT patients.

    DOI: 10.1016/j.anl.2020.03.003

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  8. Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss Reviewed

    Yang Cheng-Jui, Yoshida Tadao, Sugimoto Satofumi, Teranishi Masaaki, Kobayashi Masumi, Nishio Naoki, Naganawa Shinji, Sone Michihiko

    ACTA OTO-LARYNGOLOGICA   Vol. 141 ( 1 ) page: 5 - 9   2021.1

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    Language:Japanese   Publisher:Acta Oto-Laryngologica  

    Background: High signals in the inner ear of idiopathic sudden sensorineural hearing loss (ISSNHL) on magnetic resonance imaging (MRI) have been reported, but no quantitative evaluation has yet been done. Objectives: To evaluate hearing outcomes and cochlear signal intensities on 3-T heavily T2-weighted three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (hT2W-3D-FLAIR) in patients with ISSNHL. Materials and methods: Twenty-nine patients with ISSNHL were included. Patients underwent hT2W-3D-FLAIR with intravenous gadolinium injection and pure tone audiometry (PTA) at initial visits and 3 months later. Signal intensity ratios (SIRs) were measured in the basal or apical-middle turns of the affected cochlea. A statistical analysis of relationships between SIRs and the average hearing levels (HLs) at low (125, 250, and 500 Hz) and high (2, 4, and 8 kHz) tone frequencies was performed. Results: Hearing improvements at high-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the basal turns on pre-contrast images. Similarly, hearing improvements at low-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the apical-middle turns on post-contrast images. Conclusions and significance: High SIRs on hT2W-3D-FLAIR indicate cochlear disturbances with severe ISSNHL and could provide lesion-specific prognostic information.

    DOI: 10.1080/00016489.2020.1827159

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  9. Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss

    Yang Cheng-Jui, Yoshida Tadao, Sugimoto Satofumi, Teranishi Masaaki, Kobayashi Masumi, Nishio Naoki, Naganawa Shinji, Sone Michihiko

    Acta Oto-Laryngologica   Vol. 141 ( 1 ) page: 5 - 9   2020.10

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    Language:English   Publisher:Taylor & Francis  

    Background: High signals in the inner ear of idiopathic sudden sensorineural hearing loss (ISSNHL) on magnetic resonance imaging (MRI) have been reported, but no quantitative evaluation has yet been done. Objectives: To evaluate hearing outcomes and cochlear signal intensities on 3-T heavily T2-weighted three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (hT2W-3D-FLAIR) in patients with ISSNHL. Materials and methods: Twenty-nine patients with ISSNHL were included. Patients underwent hT2W-3D-FLAIR with intravenous gadolinium injection and pure tone audiometry (PTA) at initial visits and 3 months later. Signal intensity ratios (SIRs) were measured in the basal or apical-middle turns of the affected cochlea. A statistical analysis of relationships between SIRs and the average hearing levels (HLs) at low (125, 250, and 500 Hz) and high (2, 4, and 8 kHz) tone frequencies was performed. Results: Hearing improvements at high-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the basal turns on pre-contrast images. Similarly, hearing improvements at low-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the apical-middle turns on post-contrast images. Conclusions and significance: High SIRs on hT2W-3D-FLAIR indicate cochlear disturbances with severe ISSNHL and could provide lesion-specific prognostic information.

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  10. Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders Reviewed

    Morimoto Kyoko, Yoshida Tadao, Kobayashi Masumi, Sugimoto Satofumi, Nishio Naoki, Teranishi Masaaki, Naganawa Shinji, Sone Michihiko

    ACTA OTO-LARYNGOLOGICA   Vol. 140 ( 10 ) page: 818 - 822   2020.10

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    Language:Japanese   Publisher:Acta Oto-Laryngologica  

    Background: High signal intensity in the endolymphatic duct (ED) is occasionally observed on magnetic resonance imaging (MRI) in ears that have otological disorders. Objective: The signal intensity (SI) in the ED on post-contrast MRI was investigated in subjects with various otological disorders, and the meaning of high SI in the ED was evaluated. Material and methods: 392 patients with otological disorders and 21 controls without otological symptoms underwent 3 T MRI. The SIs of the ED and the cerebellum were measured, the SI ratio (SIR) was calculated, and ears with SIR ≥4 were identified. Results: A high SIR was identified in the ED of 3.7% of ears affected by definite Meniere’s disease (dMD), 100% of ears affected by large vestibular aqueduct syndrome (LVAS), and 7.1% of ears with no otological symptoms. On the whole, a significant relationship was found between the existence of vestibular or cochlear EH and the SIR in the ED. Conclusion: The MRI finding of high SI in the ED may indicate the mechanism of inner ear disturbances in ears with otological disorders, especially in those with LVAS, and it may suggest an underlying disorder in some ears in which otological symptoms are not apparent.

    DOI: 10.1080/00016489.2020.1781927

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  11. OTOF 遺伝子の新規変異が原因と考えられたAuditory neuropathy spectrum disorder の一例

    杉本 賢文, 木全 由佳理, 福永 有可里, 水野 知美, 原 大介, 小林 万純, 吉田 忠雄, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 63 ( 5 ) page: 484   2020.9

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    Language:Japanese   Publisher:一般社団法人 日本聴覚医学会  

    DOI: 10.4295/audiology.63.484

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  12. 成人両側人工内耳の装用効果と方向性マスキング解除の検討

    原 大介, 吉田 忠雄, 杉本 賢文, 小林 万純, 木全 由佳理, 福永 有可里, 水野 知美, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 63 ( 5 ) page: 342   2020.9

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    Language:Japanese   Publisher:一般社団法人 日本聴覚医学会  

    DOI: 10.4295/audiology.63.342

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  13. 内リンパ水腫症例における Wideband Tympanometry の応用と評価

    小林 万純, 吉田 忠雄, 杉本 賢文, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 63 ( 5 ) page: 367   2020.9

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    Language:Japanese   Publisher:一般社団法人 日本聴覚医学会  

    DOI: 10.4295/audiology.63.367

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  14. リニア乗車時における人工内耳装用者の聴こえの変化に関するアンケート聴取

    木全 由佳理, 原 大介, 吉田 忠雄, 杉本 賢文, 小林 万純, 福永 有可里, 水野 知美, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 63 ( 5 ) page: 430   2020.9

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    Language:Japanese   Publisher:一般社団法人 日本聴覚医学会  

    DOI: 10.4295/audiology.63.430

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  15. Effects of endolymphatic hydrops on acoustic energy absorbance Reviewed

    Kobayashi Masumi, Yoshida Tadao, Sugimoto Satofumi, Shimono Mariko, Teranishi Masaaki, Naganawa Shinji, Sone Michihiko

    ACTA OTO-LARYNGOLOGICA   Vol. 140 ( 8 ) page: 626 - 631   2020.7

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    Language:Japanese   Publisher:Acta Oto-Laryngologica  

    Background: The presence of endolymphatic hydrops (EH) may cause hearing loss and affect the transmission of acoustic energy to the inner ear. Objectives: Acoustic energy absorbance on wideband acoustic immittance (WAI) was evaluated, focusing especially on EH in the vestibule. Material and methods: A total of 32 ears from 16 patients who underwent 3-T magnetic resonance imaging (MRI) to evaluate the presence of EH were examined, retrospectively. The degree of EH in the vestibule was classified into three grades (no, mild, and significant), and pure tone audiometry (PTA) and WAI were measured before and after a glycerol drip. Results: Ears with significant EH showed significantly higher hearing levels and air-bone gaps (ABG), and higher absorbance values on WAI at low frequencies (560–600 Hz) than ears with mild or no EH. Changes in absorbance values were observed in some ears without threshold change on PTA. Conclusions and Significance: This study showed significantly higher absorbance values of acoustic energy with significant vestibular EH at low frequencies. Considering ABGs observed in ears with significant EH, the presence of EH in the vestibule might cause an obstacle to the transmission of acoustic energy to the inner ear.

    DOI: 10.1080/00016489.2020.1754460

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  16. 名古屋大学における軟骨伝導補聴器の装用状況

    杉本 賢文, 小林 万純, 吉田 忠雄, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 62 ( 5 ) page: 406   2019.10

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    DOI: 10.4295/audiology.62.406

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  17. Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI

    Sugimoto Satofumi, Yoshida Tadao, Teranishi Masaaki, Kobayashi Masumi, Shimono Mariko, Naganawa Shinji, Sone Michihiko

    OTOLOGY & NEUROTOLOGY   Vol. 39 ( 10 ) page: 1229 - 1234   2018.12

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    Language:Japanese   Publisher:Otology and Neurotology  

    Objective: The objective of this study was to investigate the relationship between endolymphatic hydrops (EH) and hearing level or vestibular symptoms by focusing on EH herniation into the semicircular canal (SCC). Study Design: Retrospective study. Setting: University hospital. Methods: The study included 1,548 ears of 775 patients who underwent magnetic resonance imaging (MRI) examination in our university hospital to investigate possible EH. MRI was performed 4 hours after intravenous injection of a standard dose of gadodiamide hydrate and/or 24 hours after intratympanic injection of gadopentetate dimeglumine diluted eightfold. The hearing threshold and vestibular symptoms were compared between ears with unilateral and bilateral EH herniation into the SCC and between ears having vestibular EH adjacent to the stapes footplate with or without EH herniation. Results: Forty-four ears (19 men and 25 women, mean age 53.6 yr) showed EH herniation into the SCC. The average hearing thresholds at 500 to 4000 Hz and presence of vestibular EH adjacent to the stapes footplate were significantly higher in ears with unilateral herniation than in those with bilateral herniation. The average hearing thresholds at 500 and 1000 Hz were significantly higher in the group of ears having adjacency with herniation than in those without herniation. Vestibular symptoms did not differ significantly between groups. Conclusion: Unilateral herniation occurs with EH progression. Bilateral herniation may occur regardless of EH progression and might be influenced by other factors that alter the membranous labyrinth. Key Words: Endolymphatic hydrops—Herniation—Magnetic resonance imaging—Menière’s disease.

    DOI: 10.1097/MAO.0000000000002022

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  18. 前庭内リンパ水腫が音響エネルギーのアブソーバンスへ及ぼす影響

    小林 万純, 杉本 賢文, 吉田 忠雄, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 61 ( 5 ) page: 494 - 494   2018.9

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    DOI: 10.4295/audiology.61.494

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  19. 名古屋大学附属病院における軟骨伝導補聴器外来の現状

    杉本 賢文, 小林 万純, 吉田 忠雄, 寺西 正明, 曾根 三千彦

    AUDIOLOGY JAPAN   Vol. 61 ( 5 ) page: 344 - 344   2018.9

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    DOI: 10.4295/audiology.61.344

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  20. Thyroplasty type Ⅰ +Ⅲ: Treatment for dysphonia with severe vocal fold atrophy in oculopharyngeal muscular dystrophy

    SHIMONO Mariko, NAKAMURA Kazuhiro, FUJIMOTO Yasushi, KOBAYASHI Masumi, KINOSHITA Wakako, YOKOI Sayaka, NISHIO Naoki, MARUO Takashi, HIRAMATSU Mariko, SAWAKI Masaharu, HARA Daisuke, KADONO Izumi, WATANABE Hirohisa, SONE Michihiko

    jibi to rinsho   Vol. 64 ( 5 ) page: 189 - 196   2018.9

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    <p>Thyroplasty type Ⅰ and Ⅲ (TP Ⅰ + Ⅲ) has improved dysphonia with severe vocal fold atrophy in cases of oculopharyngeal muscular dystrophy (OPMD). The patient was a 68-year-old man who had been diagnosed with OPMD 10 years before the operation. He underwent cricopharyngeal myotomy three years after the diagnosis, and his swallowing function improved. Three years later, he became annoyed by his altered voice. Autologous fat injections twice and collagen injections twice to the right vocal cord were performed over the subsequent few years;however, his voice quality was not improved due to the absorption of fat and collagen and the marked progression of vocal fold atrophy. TP Ⅰ + Ⅲ was performed to improve his breathy voice, while an endoscopic examination of swallowing showed that his swallowing function had deteriorated steadily. After the operation, each vocal cord was shifted toward the midline successfully, although the vocal cord closure was not perfect. TP Ⅰ + Ⅲ seems to be an effective phonosurgical technique for the treatment of dysphonia due to severe vocal fold atrophy.</p>

    DOI: 10.11334/jibi.64.5_189

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MISC 1

  1. Labyrinthine calcification in ears with otitis media and antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV): A report of two cases.

    Yoshida T, Kobayashi M, Sugimoto S, Naganawa S, Sone M

    Auris, nasus, larynx     2022.1

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    Language:English   Publisher:Auris Nasus Larynx  

    Otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV) has been proposed as a new type of otitis media. The hearing loss caused by OMAAV can be expected to improve with early detection and intervention, but if it continues to worsen and leads to deafness, it is challenging to recover the patient's hearing. When bilateral deafness occurs, cochlear implant (CI) surgery is the only way to improve hearing. Here, Case 1 showed unilateral cochlear calcification, and Case 2 showed bilateral cochlear calcification. In Case 1, CI surgery was performed on the ear lacking calcification, and in Case 2 it was performed on the ear with milder calcification. In Case 2, granulation was present from the tympanic space to the mastoid, the round window was closed, and the basal turn of the cochlea was narrowed. Such calcification of the cochlea caused by OMAAV has not been reported so far. It is essential to detect these changes by computed tomography scans at an early stage and to perform CI surgery at an appropriate time, because hearing improvements are not expected in patients who become deaf because of OMAAV.

    DOI: 10.1016/j.anl.2022.01.004

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