Updated on 2022/03/16

写真a

 
ISHIKAWA Eri
 
Organization
Nagoya University Hospital Gastroenterology Assistant professor of hospital
Title
Assistant professor of hospital
External link

Degree 1

  1. 博士(消化器内科学)医博第3730号 ( 2019.3   名古屋大学 ) 

Research History 1

  1. Nagoya University   Assistant professor of hospital

    2020.2

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    Country:Japan

Education 1

  1. Nagoya City University

Professional Memberships 6

  1. 日本内科学会

  2. 日本消化器病学会

  3. 日本消化器内視鏡学会

  4. 日本病理学会

  5. 日本消化管学会

  6. 日本臨床腫瘍学会

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Papers 64

  1. Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era Reviewed International journal

    Ishikawa Eri, Nakamura Masanao, Satou Akira, Shimada Kazuyuki, Nakamura Shotaro

    CANCERS   Vol. 14 ( 2 )   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cancers  

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) typically arises from sites such as the stomach, where there is no organized lymphoid tissue. Close associations between Helicobacter pylori and gastric MALT lymphoma or Campylobacter jejuni and immunoproliferative small intestinal disease (IPSID) have been established. A subset of tumors is associated with chromosomal rearrangement and/or genetic alterations. This disease often presents as localized disease, requiring diverse treatment approaches, from antibiotic therapy to radiotherapy and immunochemotherapy. Eradication therapy for H. pylori effectively cures gastric MALT lymphoma in most patients. However, treatment strategies for H. pylori-negative gastric MALT lymphoma are still challenging. In addition, the effectiveness of antibiotic therapy has been controversial in intestinal MALT lymphoma, except for IPSID. Endoscopic treatment has been noted to usually achieve complete remission in endoscopically resectable colorectal MALT lymphoma with localized disease. MALT lymphoma has been excluded from post-transplant lymphoproliferative disorders with the exception of Epstein–Barr virus (EBV)-positive marginal zone lymphoma (MZL). We also describe the expanding spectrum of EBV-negative MZL and a close association of the disease with the gastrointestinal tract.

    DOI: 10.3390/cancers14020446

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  2. Epstein-Barr Virus Positive B-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract Reviewed International journal

    Ishikawa Eri, Satou Akira, Nakamura Masanao, Nakamura Shigeo, Fujishiro Mitsuhiro

    CANCERS   Vol. 13 ( 15 )   2021.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cancers  

    Epstein-Barr virus positive B-cell lymphoproliferative disorder (EBV+ B-LPD) encompasses a broad clinicopathological spectrum and distinct clinical behavior that relatively favors the gastrointestinal (GI) tract. In this review, we provide an update on the clinicopathological features and biological behavior of EBV-positive mucocutaneous ulcer (EBVMCU) and primary EBV+ diffuse large B-cell lymphoma (DLBCL) of the GI tract. EBVMCU is a newly recognized entity but well known as an indolent and self-limited EBV+ B-LPD occurring in various immunodeficiencies. In contrast, EBV+ DLBCL constitutes the largest group of EBV+ B-LPDs and is regarded as an aggressive neoplasm. These two distinct diseases have historically been distinguished in the reappraisal of age-related EBV-associated B-LPDs but are challenging in routine practice regarding their differential diagnostic and therapeutic approaches. An increasing number of reports indicate that they are epidemiologically prevalent beyond western and eastern countries, but their comprehensive analysis is still limited. We also describe the PD-L1 positivity of tumorous large cells and non-malignant immune cells, which is relevant for the prognostic delineation among patients with primary DLBCL of the GI tract with and without EBV on tumor cells.

    DOI: 10.3390/cancers13153815

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  3. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables Reviewed International journal

    Ishikawa Eri, Nakaguro Masato, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Maeda Keiko, Furukawa Kazuhiro, Shimoyama Yoshie, Kawashima Hiroki, Fujishiro Mitsuhiro

    PATHOLOGY INTERNATIONAL   Vol. 71 ( 1 ) page: 33 - 41   2021.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pathology International  

    DOI: 10.1111/pin.13048

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  4. Reappraisal of Primary Epstein-Barr Virus (EBV)-positive Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract Comparative Analysis Among Immunosuppressed and Nonimmunosuppressed Stage I and II-IV Patients Reviewed International journal

    Miyagi Shouhei, Ishikawa Eri, Nakamura Masanao, Shimada Kazuyuki, Yamamura Takeshi, Furukawa Kazuhiro, Tanaka Tsutomu, Mabuchi Seiyo, Tsuyuki Yuta, Kohno Kei, Sakakibara Ayako, Satou Akira, Kato Seiichi, Fujishiro Mitsuhiro, Nakamura Shigeo

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   Vol. 44 ( 9 ) page: 1173 - 1183   2020.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Journal of Surgical Pathology  

    DOI: 10.1097/PAS.0000000000001499

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  5. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma Reviewed International journal

    Ishikawa Eri, Nakamura Masanao, Shimada Kazuyuki, Tanaka Tsutomu, Satou Akira, Kohno Kei, Sakakibara Ayako, Furukawa Kazuhiro, Yamamura Takeshi, Miyahara Ryoji, Nakamura Shigeo, Kato Seiichi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   Vol. 55 ( 1 ) page: 39 - 50   2020.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Gastroenterology  

    DOI: 10.1007/s00535-019-01616-3

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  6. Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: Prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells Reviewed International journal

    Ishikawa Eri, Kato Seiichi, Shimada Kazuyuki, Tanaka Tsutomu, Suzuki Yuka, Satou Akira, Kohno Kei, Sakakibara Ayako, Yamamura Takeshi, Nakamura Masanao, Miyahara Ryoji, Goto Hidemi, Nakamura Shigeo, Hirooka Yoshiki

    CANCER MEDICINE   Vol. 7 ( 12 ) page: 6051 - 6063   2018.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cancer Medicine  

    DOI: 10.1002/cam4.1875

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  7. A prognostic model, including the EBV status of tumor cells, for primary gastric diffuse large B-cell lymphoma in the rituximab era Reviewed International journal

    Ishikawa Eri, Tanaka Tsutomu, Shimada Kazuyuki, Kohno Kei, Satou Akira, EladI Ahmed E., Sakakibara Ayako, Furukawa Kazuhiro, Funasaka Kohei, Miyahara Ryoji, Nakamura Masanao, Goto Hidemi, Nakamura Shigeo, Kato Seiichi, Hirooka Yoshiki

    CANCER MEDICINE   Vol. 7 ( 7 ) page: 3510 - 3520   2018.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Doctoral thesis   Publisher:Cancer Medicine  

    DOI: 10.1002/cam4.1595

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  8. Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images Reviewed International journal

    Hirai Keiko, Kuwahara Takamichi, Furukawa Kazuhiro, Kakushima Naomi, Furune Satoshi, Yamamoto Hideko, Marukawa Takahiro, Asai Hiromitsu, Matsui Kenichi, Sasaki Yoji, Sakai Daisuke, Yamada Koji, Nishikawa Takahiro, Hayashi Daijuro, Obayashi Tomohiko, Komiyama Takuma, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    GASTRIC CANCER   Vol. 25 ( 2 ) page: 382 - 391   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Gastric Cancer  

    Background: Endoscopic ultrasonography (EUS) is useful for the differential diagnosis of subepithelial lesions (SELs); however, not all of them are easy to distinguish. Gastrointestinal stromal tumors (GISTs) are the commonest SELs, are considered potentially malignant, and differentiating them from benign SELs is important. Artificial intelligence (AI) using deep learning has developed remarkably in the medical field. This study aimed to investigate the efficacy of an AI system for classifying SELs on EUS images. Methods: EUS images of pathologically confirmed upper gastrointestinal SELs (GIST, leiomyoma, schwannoma, neuroendocrine tumor [NET], and ectopic pancreas) were collected from 12 hospitals. These images were divided into development and test datasets in the ratio of 4:1 using random sampling; the development dataset was divided into training and validation datasets. The same test dataset was diagnosed by two experts and two non-experts. Results: A total of 16,110 images were collected from 631 cases for the development and test datasets. The accuracy of the AI system for the five-category classification (GIST, leiomyoma, schwannoma, NET, and ectopic pancreas) was 86.1%, which was significantly higher than that of all endoscopists. The sensitivity, specificity, and accuracy of the AI system for differentiating GISTs from non-GISTs were 98.8%, 67.6%, and 89.3%, respectively. Its sensitivity and accuracy were significantly higher than those of all the endoscopists. Conclusion: The AI system, classifying SELs, showed higher diagnostic performance than that of the experts and may assist in improving the diagnosis of SELs in clinical practice.

    DOI: 10.1007/s10120-021-01261-x

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  9. 今月の主題 炎症性腸疾患の粘膜治癒を再考する 主題 Crohn病における小腸粘膜治癒評価の意義-小腸カプセル内視鏡の立場から

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 石川 恵里, 角嶋 直美, 古川 和宏, 飯田 忠, 水谷 泰之, 石川 卓哉, 大野 栄三郎, 川嶋 啓揮, 藤城 光弘

    胃と腸   Vol. 57 ( 2 ) page: 183 - 189   2022.2

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    Language:Japanese   Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403202660

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  10. Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancer Reviewed International journal

    Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ito Nobuhito, Hirose Takashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:International Journal of Clinical Oncology  

    Background and aim: Esophageal stenosis is a serious complication after endoscopic submucosal dissection (ESD) for thoracic esophageal cancer (TEC), and steroid has been applied for stenosis prevention. However, the rate of stenosis and effect of steroid for ESD of cervical esophageal cancer (CEC) remain unknown. The aim was to clarify the rate and managements of post-ESD stenosis for CEC. Methods: A total of 325 lesions with 272 patients who underwent ESD for esophageal cancers were enrolled and were divided to the CEC group (43 lesions) or the TEC group (282 lesions). Patient characteristics, clinicopathological features, procedure-related outcomes of esophageal ESD, stenosis rate and clinical outcome of steroid use cases were evaluated. Results: More patients in the CEC group received preventive steroid treatment compared to the TEC group (37.2% vs 14.5%, P = 0.001). The rate of post-ESD stenosis tended to be higher in the CEC group (11.6%) than in the TEC group (6.7%). For cases of 3/4 ≤ of circumference, local injection with oral steroid had lower stenosis rate than local injection only in both groups (CEC 40% vs 100%, TEC 30.7% vs 56.3%). More sessions and longer duration of dilation were needed to release the stenosis in the CEC group (20 times vs. 5 times, P = 0.015; 196 days vs. 55 days, P = 0.043). Conclusion: The post-ESD stenosis rate of CEC tended to be higher than that of TEC. More intensive preventive measures for post-ESD stenosis may be needed for CEC than TEC.

    DOI: 10.1007/s10147-022-02139-3

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  11. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients Reviewed International journal

    Nakamura Masanao, Maeda Keiko, Yamamoto Kenta, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki

    DIGESTION     page: 1 - 12   2022.2

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    DOI: 10.1159/000521929

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  12. Factors related to delayed adverse events of endoscopic submucosal dissection in the duodenum. Reviewed International journal

    Kawamura T, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M

    Digestive diseases (Basel, Switzerland)     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000522362

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  13. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis Reviewed International journal

    Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Ishikawa E., Ishikawa T., Kakushima N., Furukawa K., Ohno E., Kawashima H., Honda T., Ishigami M., Fujishiro M.

    Nagoya Journal of Medical Science   Vol. 84 ( 1 ) page: 169 - 179   2022

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nagoya Journal of Medical Science  

    Ulcerative colitis (UC) is an incurable, chronic inflammatory disease of the large bowel whose etiology and pathogenesis have not yet been comprehensively explained. Tofacitinib is a small molecule Janus kinase inhibitor that was introduced for treating refractory UC. We aimed to examine the efficacy and safety of tofacitinib for the treatment of 18 patients with UC. Continuous treatment rates were 50, 38, and 33% at 8, 24, and 52 weeks, respectively. Overall, 83.3% of these patients showed tumor necrosis factor (TNF) antibody failure status. When the effective status was defined as a Lichtiger index (LI) that decreased by 3 points or more or was less than 4 points and remission status was defined as an LI less than 4 points, the effective and remission rates (%) at 2, 8, and 16 weeks were 55.5 (10/18) and 22.2 (4/18), 38.8 (7/18) and 33.3 (6/18), and 38.8 (7/18) and 38.8 (7/18), respectively. Background characteristics of 2-week responders and non-responders were compared. C-reactive protein level in responders was significantly lower than that in non-responders, and the hemoglobin level in responders was significantly higher than that in non-responders. This study provides preliminary results of the effectiveness of tofacitinib even for TNF antibody and tacrolimus failure patients.

    DOI: 10.18999/nagjms.84.1.169

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  14. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching Reviewed International journal

    Saito Masashi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Mizutani Yasuyuki, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 27 ( 47 ) page: 8182 - 8193   2021.12

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    BACKGROUND Cold polypectomy (CP) is a simple and safe procedure for polyps less than 10 mm in size; however, there is concern about local recurrence following CP because of unidentified margins of excised specimens and the lack of tumor suppression effect by coagulation. Some clinical trials have evaluated local persistent recurrence; their results suggest that a higher rate of local recurrence has not been documented so far. There were few reports that observed the course over long periods of time after CP in clinical practice. AIM To evaluate the presence of local recurrence following CP and hot polypectomy (HP) using propensity score matching. METHODS We analyzed 275 patients who underwent polypectomy for non-pedunculated colorectal polyps less than 10 mm (959 Lesions) between October 2016 and 2017 and underwent follow-up endoscopy subsequently. We divided them into the CP group (706 Lesions), wherein CP was performed, and the HP group (253 Lesions), wherein HP was performed. Using propensity score matching, we extracted 215 Lesions in each group and evaluated the local recurrence and content of CP in the real clinic and adverse events using medical records. RESULTS After propensity score matching, there were no significant differences in the patients’ and their endoscopic background (age, use of antithrombotics, indications, size, morphology, location of polyps, and polypectomy device) between the groups. The mean duration between colorectal polypectomy and the next follow-up colonoscopy was 17.5 ± 7.1 (range, 6-39) mo in the CP group and 15.7 ± 6.0 (range, 6-35) mo in the HP group, which was significantly longer in the CP group (P = 0.005). The local recurrence rate was 0.93% in the CP group and 0.93% in the HP group, without a significant difference (P = 0.688). Additionally, no differences were observed in the macroscopic en bloc resection rate, histopathological complete resection rate, and pathological results between the groups. Adverse events did not occur in either group. CONCLUSION Local recurrence after CP was equivalent to that following HP in clinical practice. CP is useful and safe in the treatment of non-pedunculated polyps of less than 10 mm.

    DOI: 10.3748/wjg.v27.i47.8182

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  15. 特集 Cold polypectomyの課題 4.症例からみえた課題(1)小腸ポリープに対するcold polypectomy

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 角嶋 直美, 古川 和宏, 川嶋 啓揮

    臨床消化器内科   Vol. 37 ( 1 ) page: 93 - 96   2021.12

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    Language:Japanese   Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000002065

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  16. Diagnostic yield of colon capsule endoscopy for Crohn’s disease lesions in the whole gastrointestinal tract Reviewed International journal

    Yamada K.

    BMC Gastroenterology   Vol. 21 ( 1 )   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BMC Gastroenterology  

    DOI: 10.1186/s12876-021-01657-0

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  17. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival Reviewed International journal

    Yamada Kentaro, Sawada Tsunaki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Ishikawa Eri, Iida Tadashi, Mizutani Yasuyuki, Kakushima Naomi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Furune Satoshi, Hase Tetsunari, Yokota Kenji, Maeda Osamu, Hashimoto Naozumi, Akiyama Masashi, Ando Yuichi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 27 ( 41 ) page: 7190 - 7206   2021.11

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    BACKGROUND Despite the popularity of immune checkpoint inhibitors (ICIs) in the treatment of advanced cancer, patients often develop gastrointestinal (GI) and non-GI immune- related adverse events (irAEs). The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous reports. This necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI treatment. AIM To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with ICIs. METHODS In this single-center, retrospective, observational study, we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August 2020. We analyzed the clinical characteristics of patients who received ICI treatment. We also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer (LC) and malignant melanoma (MM). Kaplan-Meier analysis was used to compare the median overall survival (OS). Multivariate Cox proportional hazards models were used to identify prognostic factors. A P value < 0.05 was considered statistically significant. RESULTS GI-irAEs occurred in 34 of 605 patients (5.6%) treated with an anti-programmed cell death-1/programmed death-ligand 1 (anti-PD-1/PD-L1) antibody alone and in nine of 56 patients (16.1%) treated with an anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibody alone or a combination of anti-PD-1 and anti-CTLA-4 antibodies. The cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies (P < 0.05). In 130 patients with MM, OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs (P = 0.035). In contrast, in 209 patients with non-small cell LC, there was no significant difference in OS between the groups. The multivariate analyses showed that a performance status of 2-3 (hazard ratio: 2.406; 95% confidence interval: 1.125-5.147; P = 0.024) was an independent predictive factor for OS in patients with MM. CONCLUSION Patients receiving anti-CTLA-4 antibodies develop GI-irAEs more frequently and with higher severity than those receiving anti-PD-1/PD-L1 antibodies. Continuing ICI treatment in patients with MM with GI-irAEs have better OS.

    DOI: 10.3748/wjg.v27.i41.7190

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  18. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound. Reviewed International journal

    Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 7 ) page: 1364 - 1370   2021.10

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    Objectives: Pancreatic metastases from renal cell carcinoma (PRCC) often appear many years after treatment of the primary tumor, and differentiation from pancreatic neuroendocrine neoplasm (PanNEN) can be challenging due to their hypervascularity. Here, we investigated the utility of endoscopic ultrasound (EUS) for differentiation of these conditions. Methods: A retrospective analysis was performed in 17 and 79 consecutive patients with pathologically proven PRCC and non-functional PanNEN who were examined by EUS. In cases examined by EUS elastography or contrast-enhanced harmonic EUS (CH-EUS), the lesions were classified as stiff or soft, or into three vascular patterns as hypoechoic, isoechoic, and hyperechoic. CH-EUS images at 20 s, 40 s, 60 s, 3 min and 5 min were used for evaluation. EUS images were independently reviewed by two readers who were blinded to all clinical information. Results: The patients with PRCC were significantly older than those with PanNEN (median, 71 (range, 45–81) vs. 58 (22–76), P = 0.001) and more often had multiple tumors (6/17 (35%) vs. 7/79 (9%), P = 0.010). In EUS findings, PRCC lesions significantly more frequently had a marginal hypoechoic zone (MHZ) (11/17 (65%) vs. 27/79 (34%), P = 0.028), being classified as soft (12/13 (92%) vs. 26/58 (45%), P = 0.002), and showed sustained hyperechoic vascular patterns at 5 min (7/8 (88%) vs. 4/59 (7%), P < 0.001) compared to PanNEN lesions. Conclusions: The presence of a MHZ, a soft lesion, and a sustained hyperechoic vascular pattern in EUS may be useful for differentiating PRCC from PanNEN.

    DOI: 10.1016/j.pan.2021.07.001

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  19. Diagnostic utility of programmed cell death ligand 1 (clone SP142) immunohistochemistry for malignant lymphoma and lymphoproliferative disorders: A brief review. Reviewed International journal

    Sakakibara A, Kohno K, Ishikawa E, Suzuki Y, Tsuyuki Y, Shimada S, Shimada K, Satou A, Takahara T, Ohashi A, Takahashi E, Kato S, Nakamura S, Asano N

    Journal of clinical and experimental hematopathology : JCEH     2021.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:日本リンパ網内系学会  

    <p>The programmed cell death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in tumor cell escape from immune control and has been most extensively investigated for therapeutic purposes. However, PD-L1 immunohistochemistry is still not used widely for diagnosis. We review the diagnostic utility of PD-L1 (by clone SP142) immunohistochemistry in large-cell lymphomas, mainly consisting of classic Hodgkin lymphoma (CHL) and diffuse large B-cell lymphoma (DLBCL). Neoplastic PD-L1 (nPD-L1) expression on Hodgkin and Reed-Sternberg cells is well-established among prototypic CHL. Of note, EBV+ CHL often poses a challenge for differential diagnosis from peripheral T-cell lymphoma with EBV+ non-malignant large B-cells; their distinction is based on the lack of PD-L1 expression on large B-cells in the latter. The nPD-L1 expression further provides a good diagnostic consensus for CHL with primary extranodal disease conceivably characterized by a combined pathogenesis of immune escape of tumor cells and immunodeficiency. Compared with CHL, the nPD-L1 expression rate is much lower in DLBCL, highlighting some specific subgroups of intravascular large B-cell lymphoma, primary mediastinal large B-cell lymphoma, and EBV+ DLBCL. They consist of nPD-L1-positive and -negative subgroups, but their clinicopathological significance remains to be elucidated. Microenvironmental PD-L1 positivity on immune cells may be associated with a favorable prognosis in extranodal DLBCL. PD-L1 (by SP142) immunohistochemistry has helped us to understand the immune biology of lymphoid neoplasms possibly related by immune escape and/or immunodeficiency. However, knowledge of these issues remains limited and should be clarified for diagnostic consensus in the future.</p>

    DOI: 10.3960/jslrt.21003

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  20. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study Reviewed International journal

    Otsuka Hiroyuki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawade Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Iliroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 419 - 430   2021.8

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    Patency capsule (PC) can evaluate the patency of gastrointestinal (GI) tract. We hypothesized preceding patient selection using PC would improve the successful rate of colon capsule endoscopy (CCE). Therefore, a prospective single-arm study using PC followed by CCE was conducted with a control group of CCE alone. Patients with suspected or known GI stenosis scheduled for CCE were enrolled. CCE was performed only when the PC was excreted out of the body within 33 hours of ingestion. Primary endpoint was the rate of observation of the entire GI tract within the duration of examination. The secondary endpoints were complications and CCE findings. Twenty-three patients (17 men) were enrolled. The mean age was 50.5±19.8 years. Suspected stenotic sites were 8, 5, and 10 in the small, large, and small and large bowel, respectively. Sixteen, 12, and 10 patients had abdominal pain, active inflammatory bowel disease, and history of surgery for suspected stenosis, respectively. Patency of GI tract was confirmed in 96% (22/23) of the patients by administered PC. Of the 22 patients who underwent CCE, the entire GI tract was observed in 86% (19/22). No complications were observed. The median transit times in the small bowel and colon were 99 (21–682) and 160 (5–328) minutes, respectively. CCE findings revealed ulcers, erosions, and diverticula in 5, 9, and 4 patients, respectively. In conclusion, CCE with PC might be a safer and useful modality to observe the large colon for patients with suspected GI stenosis.

    DOI: 10.18999/nagjms.83.3.419

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  21. Difference of efficacy for small bowel lesion in Crohn Reviewed International journal

    Sawada T., Nakamura M., Yamamura T., Maeda K., Ishikawa E., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 36   page: 116 - 116   2021.8

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  22. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method Reviewed International journal

    Takada Yoshihisa, Hirose Takashi, Nishida Kazuki, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY     2021.7

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    Objectives: Endoscopic submucosal dissection (ESD) in the duodenum is challenging. The water pressure method (WP-ESD) has been developed with a decreased rate of perforation. However, details of perioperative adverse events of WP-ESD are unknown. The purpose of this study was to clarify the frequency and related factors of fecal incontinence and oral regurgitation during WP-ESD. Methods: A chart-based retrospective analysis was performed on 43 patients who underwent duodenal WP-ESD. The saline volume given into the body was calculated in all cases. All adverse events during WP-ESD until 6 weeks were extracted, and factors related to intraoperative fecal incontinence or oral regurgitation were analyzed. The frequency of fecal incontinence and oral regurgitation was also compared to those of 83 conventional ESD cases. Results: In WP-ESD, intraoperative fecal incontinence occurred in 12 (28%), oral regurgitation in six (14%), and aspiration pneumonia in one patient. For fecal incontinence, the infusion speed (saline volume divided by resection time) around 17 mL/min was a significant factor in multivariable analysis. For oral regurgitation, only tumor size was a significant factor in univariate analysis (P = 0.027). Significant difference was observed in the frequency of fecal incontinence between WP-ESD and conventional ESD (28% vs. 0%, P < 0.001), but no difference was observed in oral regurgitation or aspiration pneumonia. Conclusions: Intraoperative fecal incontinence is a unique adverse event of WP-ESD related to the infusion speed. WP-ESD did not pose a risk for oral regurgitation, but we should be aware of the risk in large tumor cases.

    DOI: 10.1111/den.14070

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  23. Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography Reviewed International journal

    Yamada Kenta, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Ishigami Masatoshi, Fujishiro Mitsuhiro

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY     2021.7

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    DOI: 10.21037/qims-21-403

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  24. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors. Reviewed International journal

    Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Nishida K, Yokoi T, Kawashima H, Fujishiro M

    Digestion     page: 1 - 8   2021.6

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    DOI: 10.1159/000516512

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  25. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors &lt;10 mm. Reviewed International journal

    Toriyama K, Yamamura T, Nakamura M, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Furukawa K, Ishikawa T, Ohno E, Kawashima H, Fujishiro M

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology     2021.5

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    DOI: 10.1016/j.ajg.2021.05.007

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  26. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis. Reviewed International journal

    Tanaka H, Kawashima H, Ohno E, Ishikawa T, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Shimoyama Y, Miyahara R, Kawabe N, Kuzuya T, Hashimoto S, Ishigami M, Hirooka Y, Fujishiro M

    BMC gastroenterology   Vol. 21 ( 1 ) page: 224   2021.5

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    DOI: 10.1186/s12876-021-01811-8

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  27. Detection of colorectal neoplasms using linked color imaging: A prospective, randomized, tandem colonoscopy trial. Reviewed International journal

    Hasegawa I, Yamamura T, Suzuki H, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Nakamura M, Fujishiro M

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     2021.4

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    DOI: 10.1016/j.cgh.2021.04.004

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  28. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports Reviewed International journal

    Murate Kentaro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 14 ( 1 ) page: 129 - 135   2021.2

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    DOI: 10.1007/s12328-020-01242-0

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  29. Collision Tumors of Gastric Adenocarcinoma and Mucosa-associated Lymphoid Tissue Lymphoma Reviewed International journal

    Kobayashi Kenichi, Furukawa Kazuhiro, Ishikawa Eri, Mitsuma Ayako, Funasaka Kohei, Kakushima Naomi, Furune Satoshi, Ito Nobuhito, Wada Hirotaka, Hirose Takashi, Muroi Koichi, Suzuki Tomohiko, Suzuki Takahiro, Hida Emiko, Hirai Keiko, Shibata Hiroyuki, Koya Toshinari, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   Vol. 60 ( 15 ) page: 2419 - 2424   2021

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    A 65-year-old woman with a history of treatment for splenic marginal zone B-cell lymphoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma underwent esophagogastroduodenoscopy. A reddish elevated lesion was found in the fundus of the stomach. On image-enhanced endoscopy, several findings, such as glandular structures of varying sizes suggesting well-differentiated adenocarcinoma, pruned blood vessels, and dilated blood vessels in deeper mucosa suggesting MALT lymphoma, were observed. The final pathological diagnosis after surgical resection was collision tumors of well-differentiated adenocarcinoma and MALT lymphoma. The features of both tumors could be observed simultaneously with image-enhanced endoscopy.

    DOI: 10.2169/internalmedicine.6124-20

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  30. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy. Reviewed International journal

    Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ishikawa T, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Canadian journal of gastroenterology & hepatology   Vol. 2021   page: 8875564   2021

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    DOI: 10.1155/2021/8875564

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  31. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer: Assessment of contrast enhancement patterns by CEH-EUS Reviewed International journal

    Yashika J.

    Pancreatology     2021

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    DOI: 10.1016/j.pan.2020.12.022

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  32. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease Reviewed International journal

    Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY     2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Gastroenterology and Hepatology (Australia)  

    DOI: 10.1111/jgh.15366

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  33. Expression of programmed cell death ligand-1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B-cell lymphoma of the central nervous system Reviewed International journal

    Tsuyuki Yuta, Ishikawa Eri, Kohno Kei, Shimada Kazuyuki, Ohka Fumiharu, Suzuki Yuka, Mabuchi Seiyo, Satou Akira, Takahara Taishi, Kato Seiichi, Miyagi Shohei, Ozawa Hiroyuki, Kawano Tasuku, Takagi Yusuke, Hiraga Junji, Wakabayashi Toshihiko, Nakamura Shigeo

    NEUROPATHOLOGY     2020.12

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    DOI: 10.1111/neup.12705

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  34. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms Reviewed International journal

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Suzuki Hiroto, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTION     2020.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Digestion  

    DOI: 10.1159/000511589

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  35. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy Reviewed International journal

    Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 26 ( 42 ) page: 6669 - 6678   2020.11

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    DOI: 10.3748/wjg.v26.i42.6669

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  36. Usefulness of endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of autoimmune pancreatitis using a 22-gauge Franseen needle: a prospective multicenter study Reviewed International journal

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Hayashi Daijuro, Hiramatsu Takeshi, Matsubara Hiroshi, Suzuki Takahisa, Kuwahara Takamichi, Ishikawa Eri, Shimoyama Yoshie, Kinoshita Fumie, Hirooka Yoshiki, Fujishiro Mitsuhiro

    ENDOSCOPY   Vol. 52 ( 11 ) page: 978 - 985   2020.11

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    DOI: 10.1055/a-1183-3583

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  37. New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms Reviewed International journal

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Furukawa Kazuhiro, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE     2020.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:International Journal of Colorectal Disease  

    DOI: 10.1007/s00384-020-03790-w

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  38. 特集 分子標的時代のIBD 診療 -IBD の寛解導入,寛解維持の実践 3.IBD 治療における寛解導入と寛解維持に関するトピック(5)UC 関連腫瘍の早期診断と治療

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 喜田 裕一, 古川 和宏, 川嶋 啓揮, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 10 ) page: 1267 - 1273   2020.8

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    DOI: 10.19020/cg.0000001325

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  39. 特集 クローン病小腸狭窄病変に対する内視鏡的バルーン拡張術─基本からピットフォールまで Ⅱ.クローン病小腸狭窄病変に対するバルーン拡張術(4)クローン病におけるバルーン拡張術のコツ a.ダブルバルーン内視鏡の立場から

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 恵里, 古川 和宏, 角嶋  直美, 藤城 光弘

    INTESTINE   Vol. 24 ( 3 ) page: 197 - 202   2020.8

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    DOI: 10.19020/int.0000000486

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  40. Clinicopathological analysis of neoplastic PD-L1-positive EBV(+)diffuse large B cell lymphoma, not otherwise specified, in a Japanese cohort Reviewed International journal

    Takahara Taishi, Satou Akira, Ishikawa Eri, Kohno Kei, Kato Seiichi, Suzuki Yuka, Takahashi Emiko, Ohashi Akiko, Asano Naoko, Tsuzuki Toyonori, Nakamura Shigeo

    VIRCHOWS ARCHIV     2020.8

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    DOI: 10.1007/s00428-020-02901-w

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  41. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure Reviewed International journal

    Muroi Koichi, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Eri, Sawada Tsunaki, Ishikawa Takuya, Maeda Keiko, Yamamura Takeshi, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Funasaka Kohei, Miyahara Ryoji, Fujishiro Mitsuhiro

    DIGESTIVE DISEASES AND SCIENCES     2020.8

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    DOI: 10.1007/s10620-020-06527-5

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  42. Age-related EBV-associated B-cell lymphoproliferative disorders and other EBV plus lymphoproliferative diseases: New insights into immune escape and immunodeficiency through staining with anti-PD-L1 antibody clone SP142 Reviewed International journal

    Sakakibara Ayako, Kohno Kei, Ishikawa Eri, Suzuki Yuka, Shimada Satoko, Eladl Ahmed E., Elsayed Ahmed A., Daroontum Teerada, Satou Akira, Takahara Taishi, Ohashi Akiko, Takahashi Emiko, Kato Seiichi, Nakamura Shigeo, Asano Naoko

    PATHOLOGY INTERNATIONAL   Vol. 70 ( 8 ) page: 481 - 492   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pathology International  

    DOI: 10.1111/pin.12946

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  43. Gender difference in the transabdominal ultrasound findings of solid-pseudopapillary neoplasm Reviewed International journal

    Sasaki Yutaka, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Shimoyama Yoshie, Ishikawa Eri, Fujishiro Mitsuhiro

    PANCREATOLOGY   Vol. 20 ( 5 ) page: 997 - 1003   2020.7

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    DOI: 10.1016/j.pan.2020.06.016

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  44. PD-L1 (SP142) expression in neoplastic cells predicts a poor prognosis for patients with intravascular large B-cell lymphoma treated with rituximab-based multi-agent chemotherapy Reviewed International journal

    Suzuki Yuka, Kohno Kei, Matsue Kosei, Sakakibara Ayako, Ishikawa Eri, Shimada Satoko, Shimada Kazuyuki, Mabuchi Seiyo, Takahara Taishi, Kato Seiichi, Nakamura Shigeo, Satou Akira

    CANCER MEDICINE   Vol. 9 ( 13 ) page: 4768 - 4776   2020.7

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    DOI: 10.1002/cam4.3104

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  45. Syncytial variant of classic Hodgkin lymphoma: Four cases diagnosed with the aid of CD274/programmed cell death ligand 1 immunohistochemistry Reviewed International journal

    Kohno Kei, Sakakibara Ayako, Iwakoshi Akari, Hasegawa Masaki, Adachi Shiro, Ishikawa Eri, Suzuki Yuka, Shimada Satoko, Nakaguro Masato, Shimoyama Yoshie, Takahara Taishi, Takahashi Emiko, Ohashi Akiko, Satou Akira, Kato Seiichi, Asano Naoko, Nakamura Shigeo

    PATHOLOGY INTERNATIONAL   Vol. 70 ( 2 ) page: 108 - 115   2020.2

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    DOI: 10.1111/pin.12888

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  46. 単発性小腸Peutz-Jeghers型ポリープに関する臨床的検討

    鳥山 和浩, 喜田 裕一, 江崎 正哉, 濱崎 元伸, 角嶋 直美, 古川 和宏, 藤城 光弘, 中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 恵里, 梶川 豪, 村手 健太郎

    日本小腸学会学術集会プログラム・抄録集   Vol. 4 ( 0 ) page: 39 - 39   2020

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    <p>【背景】Peutz-Jeghers症候群(PJS)は食道を除く全消化管において上皮の過形成と粘膜筋板のポリープ内への樹枝状増生を特徴とする過誤腫性ポリポーシスと皮膚、粘膜の色素斑を特徴とする常染色体優性遺伝性疾患である。一方、家族歴や皮膚、粘膜の色素沈着を伴わない単発性のPeutz-Jeghers型ポリープ(PJP)を認めることがあるが、その臨床的特徴に関する報告は少ないのが現状である。</p><p>【目的】単発性小腸PJPにおける臨床的特徴を明らかにする。</p><p>【対象】2007年4月から2020年5月までに当院で内視鏡治療を施行し、病理組織学的にPJPと診断された単発性小腸PJP16症例。</p><p>【結果】レトロスペクティブにカルテ、内視鏡画像をレビューした。性別は男性10例、女性6例、診断時年齢中央値(範囲)は61(18-82)歳。診断契機は貧血7例、黒色便5例、腹痛1例、イレウス症状1例、他疾患精査時の偶発的発見が2例。原発部位は空腸14例、回腸2例で、腫瘍径中央値(範囲)は25(4-35)mm。切除したPJP全病変で病変内に悪性腫瘍の併存は認めなかった。癌の既往歴を有したのは6例(前立腺癌2例、舌癌1例、大腸癌1例、胃癌1例、子宮体癌1例)。観察期間中央値(範囲)は4.6(0.1-53.7)ヶ月で再発並びに関連死は認めなかった。</p><p>【考察】単発性小腸PJPにおいては診断時の年齢が高く、発見契機としては出血関連症状が多く、病変部位は空腸に多い特徴があった。</p><p>【結語】当院で経験した単発性小腸PJPの臨床的特徴を検討した。今後更なる症例の蓄積が必要である。</p>

    DOI: 10.32264/shocho.4.0_39

  47. Long-term prognostic predictors of esophageal squamous cell carcinoma potentially indicated for endoscopic submucosal dissection Reviewed International journal

    Suzuki T.

    Digestion     2020

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    DOI: 10.1159/000510091

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  48. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis Reviewed International journal

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ohashi Ayako, Kajikawa Go, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   Vol. 59 ( 23 ) page: 3009 - 3014   2020

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    DOI: 10.2169/internalmedicine.5302-20

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  49. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE Reviewed International journal

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Pu Leonardo Zorron Cheng Tao, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB155 - AB155   2019.6

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  50. 今月の主題 知っておきたい小腸疾患 主題 小腸の非腫瘍性疾患-小腸リンパ管拡張症

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 丹羽 慶樹, 石川 恵里, 大塚 裕之, 鈴木 悠土, 西川 貴広, 石田 哲也, 久野 剛史, 服部 峻, 山田 啓策, 廣岡 芳樹, 藤城 光弘

    胃と腸   Vol. 54 ( 4 ) page: 532 - 536   2019.4

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    DOI: 10.11477/mf.1403201630

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  51. Divergence and heterogeneity of neoplastic PD-L1 expression: Two autopsy case reports of intravascular large B-cell lymphoma Reviewed International journal

    Sakakibara Ayako, Inagaki Yuichiro, Imaoka Eiki, Sakai Yu, Ito Masafumi, Ishikawa Eri, Shimada Satoko, Shimada Kazuyuki, Suzuki Yuka, Nakamura Shigeo, Satou Akira, Kohno Kei

    PATHOLOGY INTERNATIONAL   Vol. 69 ( 3 ) page: 148 - 154   2019.3

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    DOI: 10.1111/pin.12757

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  52. Immune evasion-related extranodal large B-cell lymphoma: A report of six patients with neoplastic PD-L1-positive extranodal diffuse large B-cell lymphoma Reviewed International journal

    Suzuki Yuka, Sakakibara Ayako, Shimada Kazuyuki, Shimada Satoko, Ishikawa Eri, Nakamura Shigeo, Kato Seiichi, Takahara Taishi, Asano Naoko, Satou Akira, Kohno Kei

    PATHOLOGY INTERNATIONAL   Vol. 69 ( 1 ) page: 13 - 20   2019.1

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    DOI: 10.1111/pin.12742

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  53. Neoplastic PD-L1 expression on interdigitating dendritic cell sarcoma: A supplementary study of a case report Reviewed International journal

    Sakakibara Ayako, Takahashi Emiko, Ishikawa Eri, Kohno Kei, Asano Naoko, Nakamura Shigeo

    PATHOLOGY INTERNATIONAL   Vol. 68 ( 10 ) page: 577 - 578   2018.10

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    DOI: 10.1111/pin.12711

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  54. EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL Reviewed International journal

    Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB478 - AB478   2018.6

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  55. Immunohistochemical assessment of the diagnostic utility of PD-L1: a preliminary analysis of anti-PD-L1 antibody (SP142) for lymphoproliferative diseases with tumour and non-malignant Hodgkin-Reed-Sternberg (HRS)-like cells Reviewed International journal

    Sakakibara Ayako, Kohno Kei, Eladl Ahmed E., Klaisuwan Teerada, Ishikawa Eri, Suzuki Yuka, Shimada Satoko, Nakaguro Masato, Shimoyama Yoshie, Takahara Taishi, Kato Seiichi, Asano Naoko, Nakamura Shigeo, Satou Akira

    HISTOPATHOLOGY   Vol. 72 ( 7 ) page: 1156 - 1163   2018.6

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    DOI: 10.1111/his.13475

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  56. THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES Reviewed International journal

    Suzuki Hiroto, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Niwa Yoshiki, Uchida Genta, Otsuka Hiroyuki, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keisaku, Hattori Shun, Kajikawa Go, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 87 ( 6 ) page: AB489 - AB490   2018.6

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  57. Anaplastic variant of diffuse large B-cell lymphoma with hallmark cell appearance: Two cases highlighting a broad diversity in the diagnostics International journal

    Sakakibara Ayako, Kohno Kei, Kuroda Naoto, Yorita Kenji, Megahed Nirmeen A., Eladl Ahmed E., Daroontum Teerada, Ishikawa Eri, Suzuki Yuka, Shimada Satoko, Nakaguro Masato, Shimoyama Yoshie, Satou Akira, Kato Seiichi, Yatabe Yasushi, Asano Naoko, Nakamura Shigeo

    PATHOLOGY INTERNATIONAL   Vol. 68 ( 4 ) page: 251 - 255   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pathology International  

    DOI: 10.1111/pin.12653

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  58. Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression Reviewed International journal

    Sakakibara Ayako, Inagaki Yuichiro, Imaoka Eiki, Ishikawa Eri, Shimada Satoko, Shimada Kazuyuki, Suzuki Yuka, Nakamura Shigeo, Satou Akira, Kohno Kei

    JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY   Vol. 58 ( 1 ) page: 32 - 35   2018

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    DOI: 10.3960/jslrt.17037

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  59. Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study Reviewed International journal

    Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Saito Masashi, Matsuura Rinzaburou, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Yamada Keishi, Kuno Takeshi, Hattori Shun, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 32   page: 287 - 287   2017.9

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  60. One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial Reviewed International journal

    Saito Masashi, Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB365 - AB366   2017.5

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  61. Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy Reviewed International journal

    Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

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  62. Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding Reviewed International journal

    Uchida Genta, Watanabe Osamu, Nakamura Masanao, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB300 - AB300   2017.5

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  63. Clinical Factors Related to False Positive Rates of Patency Capsule Examination Reviewed International journal

    Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB305 - AB305   2017.5

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  64. The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification Reviewed International journal

    Yamamura Takeshi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Matsuura Rinzaburo, Saito Masashi, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki, Goto Hidemi

    GASTROINTESTINAL ENDOSCOPY   Vol. 85 ( 5 ) page: AB402 - AB402   2017.5

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Presentations 1

  1. 消化管原発DLBCLにおけるDouble-expressor lymphomaの臨床病理学的検討

    石川恵里

    第101回日本消化器内視鏡学会総会  2021.5.14  田中信治

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島  

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 高齢者の潰瘍性大腸炎関連大腸腫瘍におけるEBV感染とPD-L1発現の意義

    2021.3

    第9回医学研究助成 

    石川恵里

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\300000

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 炎症性腸疾患関連大腸癌の免疫微小環境に影響を与える重要因子の検索

    Grant number:21K15971  2021.4 - 2023.3

    若手研究

    石川 恵里

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )