担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ijbiomac.2024.136513

PubMed

記述言語：英語  

DOI： https://doi.org/10.1007/978-3-031-62523-7

出版者・発行元：Plasma Medicine  

Recent research into plasma-activated solutions has unveiled their considerable potential across a range of applications, including cancer treatment, industrial processes, and environmental management. This review summarizes key findings from recent studies on the effects of plasma-activated solutions, focusing on their ability to induce cell death in glioblastoma cells, enhance ethanol production in yeast, and convert organic compounds into environmentally friendly substances. The review highlights the mechanisms by which plasma-activated solutions exert their effects, such as oxidative stress induction and cellular metabolic alterations. Addition-ally, it discusses the implications of these findings for overcoming challenges in cancer therapy, improving agricultural practices, and developing novel environmental technologies. The ongoing advancements in plasma technology offer promising avenues for future research and applications, underscoring its transformative potential in both scientific and practical domains.

DOI： 10.1615/PlasmaMed.v14.i1.50

Scopus

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：New Journal of Chemistry  

Betulin is a naturally originating terpenoid, which attracted the attention of researchers due to its bioactive properties, including antitumor activity. This paper reports new betulin-imine derivatives, their synthesis, structural characterization and investigation of their antioxidant and anticancer activities. To this aim, a betulin aldehyde has been firstly prepared via an oxidation reaction using a Tempo reagent, which was further reacted with a series of aliphatic amines via an acid condensation reaction. The proposed chemical structures were confirmed using 1H-NMR and FTIR spectroscopy and single crystal X-ray diffraction, and characterized by solubility tests, ultraviolet-visible (UV-Vis) and photoluminescence spectroscopy, thermogravimetric analysis and polarized light microscopy. All the compounds were easily soluble in common organic solvents, and showed good thermal stability. They showed strong birefringence under polarized light indicating their crystalline nature, which was attributed to single crystal diffraction and they belong to the Sohnke P212121 space groups. The investigation of optical properties using photoluminescence spectroscopy revealed that all the imines emitted blue light in solution and in the solid state. The DPPH radical scavenging test showed that the antioxidant activity of betulin was significantly improved by imination with the increase of the aliphatic chain length. The antitumor activity investigated in vitro using the MTS assay on human breast cancer cell line MCF-7 (adenocarcinoma) and on non-tumorigenic epithelial cell line MCF-10A showed that the betulin-imine derivatives have improved antitumor activity and selectivity compared to neat betulin, suggesting that a medium length of the alkyl chain is favorable for the antiproliferative activity.

DOI： 10.1039/d3nj02738d

Web of Science

Scopus

出版者・発行元：Plasma Processes and Polymers  

Lactate is used in the food and pharmaceutical industries and is a crucial intermediate for synthesis. Plasma-activated lactate (PAL) in Ringer's solution was recently shown to have effective antitumor action. Small molecule aldehydes, ketones, and organic acids were produced from lactate during plasma exposure, and five-membered conjugated lactone isomers of furanone (C5H6O2) were detected formed by interactions of lactate or its fragments with •OH, organic radicals, and H2O2. 2,3-Dimethyl-tartaric acid may be the effective component in PAL for the selective killing of cancer but not normal cells and possible pathways for its synthesis are provided. Aqueous reaction mechanisms are explained, including dehydration, esterification, hydrolysis, and dimerization. This study will help develop novel cancer therapies and further plasma organic chemistry.

DOI： 10.1002/ppap.202200193

Web of Science

Scopus

記述言語：英語 著書種別：学術書

DOI： https://doi.org/10.1007/978-3-030-44230-9

開催年月日： 2024年9月

記述言語：英語   会議種別：口頭発表（招待・特別）  

国名：トルコ共和国  

開催年月日： 2024年9月

記述言語：英語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

国名：トルコ共和国  

開催年月日： 2023年11月

記述言語：英語   会議種別：口頭発表（招待・特別）  

国名：エジプト・アラブ共和国  

開催年月日： 2023年11月

会議種別：口頭発表（招待・特別）  

国名：ルーマニア  

開催年月日： 2023年3月

記述言語：英語   会議種別：口頭発表（招待・特別）  

開催地：North Carolina University, Raleigh   国名：アメリカ合衆国