研究者詳細 - 布施　新一郎

論文 - 布施　新一郎

分割表示 69 件中 41 - 60 件目／全件表示 >>

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity.

Fuse S, Suzuki K, Kuchimaru T, Kadonosono T, Ueda H, Sato S, Kizaka-Kondoh S, Nakamura H

Bioorganic & medicinal chemistry 28 巻 ( 1 ) 頁： 115207 2020年1月

マイクロフロー合成技術による次世代医薬品（ペプチド）合成法の開発

布施新一郎

月刊 PHARMSTAGE 11 巻頁： 13 - 22 2020年

Design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents. 査読有り

Fuse S, Oishi T, Matsumura K, Hayashi Y, Kawauchi S, Nakamura H

Organic & biomolecular chemistry 18 巻 ( 1 ) 頁： 93 - 101 2019年12月

The design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents 査読有り

Shinichiro Fuse, Tsukasa Oishi, Keisuke Matsumura, Yoshihiro Hayashi, Susumu Kawauchi, Hiroyuki Nakamura

Organic and Biomolecular Chemistry 18 巻 ( 1 ) 頁： 93-101 2019年12月

Single-step, rapid, and mild synthesis of β-amino acid N-carboxy anhydrides using micro-flow technology 査読有り

Naoto Sugisawa, Yuma Otake, Hiroyuki Nakamura, and Shinichiro Fuse

Chemistry an Asian Journal 15 巻 ( 1 ) 頁： 79-84 2019年11月

Peptide chain elongation using unprotected amino acids in a micro-flow reactor 査読有り

Shinichiro Fuse, Koshiro Masuda, Yuma Otake, Hiroyuki Nakamura

Chemistry a European Journal 25 巻 ( 66 ) 頁： 15091-15097 2019年11月

Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor. 査読有り

Fuse S, Masuda K, Otake Y, Nakamura H

Chemistry (Weinheim an der Bergstrasse, Germany) 25 巻 ( 66 ) 頁： 15091 - 15097 2019年11月

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity 査読有り

Shinichiro Fuse, Kensuke Suzuki, Takahiro Kuchimaru, Tetsuya Kadonosono, Hiroki Ueda, Shinichi Sato, Shinae Kizaka-Kondo, and Hiroyuki Nakamura

Bioorganic and Medicinal Chemistry 28 巻頁： 115207 2019年11月

Cover Feature: Peptide‐Chain Elongation Using Unprotected Amino Acids in a Micro‐Flow Reactor (Chem. Eur. J. 66/2019) 査読有り

Shinichiro Fuse, Koshiro Masuda, Yuma Otake, Hiroyuki Nakamura

Chemistry – A European Journal 2019年11月

Donor-acceptor polymers containing thiazole-fused benzothiadiazole acceptor units for organic solar cells 査読有り

Tomoya Nakamura, Yasuhisa Ishikura, Noriko Arakawa, Megumi Hori, Motoi Satou, Masaru Endo, Hisashi Masui, Shinichiro Fuse, Takashi Takahashi, Yasujiro Murata, Richard Murdey, Atsushi Wakamiya

RSC Advances 9 巻 ( 13 ) 頁： 7107-7114 2019年3月

Donor-acceptor polymers containing thiazole-fused benzothiadiazole acceptor units for organic solar cells.

Nakamura T, Ishikura Y, Arakawa N, Hori M, Satou M, Endo M, Masui H, Fuse S, Takahashi T, Murata Y, Murdey R, Wakamiya A

RSC advances 9 巻 ( 13 ) 頁： 7107 - 7114 2019年3月

Peptide Synthesis Utilizing Micro-flow Technology. 査読有り

Fuse S, Otake Y, Nakamura H

Chemistry, an Asian journal 13 巻 ( 24 ) 頁： 3818 - 3832 2018年12月

Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy 査読有り

Shinichiro Fuse, Miori Takizawa, Shinichi Sato, Shigetoshi Okazaki, Hiroyuki Nakamura,

Bioorganic and Medicinal Chemistry 27 巻 ( 2 ) 頁： 315-321 2018年12月

Synthesis of 3-hydroxy-4-substituted-picolinonitriles from 4-propargylaminoisoxazoles via stepwise and one-pot isoxazolopyridine formation/N-O bond cleavage sequence 査読有り

Shintaro Fukuhara, Somaraju Yugandar, Shinichiro Fuse, Hiroyuki Nakamura

3 巻 ( 12 ) 頁： 16472-16476 2018年12月

The design, synthesis, and evaluation of organic dithienopyrrole-based D-pai-A dyes for use as sensitizers in photodynamic therapy 査読有り

Shinichiro Fuse, Keisuke Matsumura, Miori Takizawa, Shinichi Sato, Hiroyuki Nakamura,

Bioorganic and Medicinal Chemistry Letters 28 巻 ( 18 ) 頁： 3099-3104 2018年10月

The design, synthesis, and evaluation of organic dithienopyrrole-based D-π-A dyes for use as sensitizers in photodynamic therapy. 査読有り

Fuse S, Matsumura K, Takizawa M, Sato S, Nakamura H

Bioorganic & medicinal chemistry letters 28 巻 ( 18 ) 頁： 3099 - 3104 2018年10月

Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides: Basic-to-Acidic Flash Switching in a Microflow Reactor. 査読有り

Otake Y, Nakamura H, Fuse S

Angewandte Chemie (International ed. in English) 57 巻 ( 35 ) 頁： 11389 - 11393 2018年8月

Recent advances in the integrated micro-flow synthesis containing photochemical reactions 査読有り

Yuma Otake, Hiroyuki Nakamura, Shinichiro Fuse

Tetrahedron Letters 59 巻 ( 18 ) 頁： 1691 - 1697 2018年5月

記述言語：英語出版者・発行元：Elsevier Ltd

Micro-flow photochemical reactions have great advantage over batch photochemical reactions due to its high light-penetration efficiency. Integrated micro-flow reaction enables efficient synthesis of structurally complex compounds from simple starting materials and it can avoid handling of explosive, toxic, unstable, or odorous intermediates. Combination of micro-flow photochemical reactions with integrated micro-flow synthesis enhances their benefits. Here we summarize recently reported integrated multi-step micro-flow synthesis containing various photochemical reactions.

DOI： 10.1016/j.tetlet.2018.03.019

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その他リンク： http://orcid.org/0000-0002-6836-4180

Synthesis of Pyrazolofuropyrazine via One-Pot S <inf>N</inf> Ar Reaction and Intramolecular Direct C-H Arylation 査読有り

Shinichiro Fuse, Megumi Inaba, Shinichi Sato, Manjusha Joshi, Hiroyuki Nakamura

Synthesis (Germany) 50 巻 ( 7 ) 頁： 1493 - 1498 2018年4月

掲載種別：研究論文（学術雑誌）

© Georg Thieme Verlag Stuttgart New York. Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot S N Ar reaction/intramolecular C-H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

DOI： 10.1055/s-0036-1591885

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その他リンク： http://orcid.org/0000-0002-6836-4180

Recent progresses in the synthesis of functionalized isoxazoles 査読有り

Taiki Morita, Somaraju Yugandar, Shinichiro Fuse, Hiroyuki Nakamura

TETRAHEDRON LETTERS 59 巻 ( 13 ) 頁： 1159 - 1171 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Isoxazole is an important pharmacophore that is critical for biological activity. The isoxazole ring ranks 33rd in frequency among the 351 ring systems found in marketed drugs, thus suggesting a great deal of interest in the synthesis of functional isoxazoles. In recent years, various approaches have been developed for the synthesis and functionalization of isoxazoles. This comprehensive survey summarizes the recent new synthetic approaches to functionalized isoxazoles, with particular focus on the last three years with regard to the following reaction types: (1) 1,3-dipolar cycloaddition, (2) condensation, (3) cycloisomerization, and (4) direct functionalization. (C) 2018 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2018.02.020

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