2025/09/16 更新

写真a

タニグチ アキノブ
谷口 顕信
TANIGUCHI Akinobu
所属
医学部附属病院 総合周産期母子医療センター 新生児部門 病院助教
職名
病院助教

学位 2

  1. 医学博士 ( 2024年6月   名古屋大学 ) 

  2. 学士(医学) ( 名古屋大学 ) 

現在の研究課題とSDGs 1

  1. 新生児医療に関する研究

 

論文 7

  1. A case of the girl with ruptured bladder caused by rectal dilatation due to imperforate anus

    Takami, N; Taniguchi, A; Suzuki, T; Miura, R; Muramatsu, Y; Sato, Y

    PEDIATRICS INTERNATIONAL   67 巻 ( 1 ) 頁: e70122   2025年1月

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    記述言語:英語   出版者・発行元:Pediatrics International  

    DOI: 10.1111/ped.70122

    Web of Science

    Scopus

    PubMed

  2. Total Hydrocortisone Dosage in the Neonatal Period May Be Related to Low Developmental Quotient in Extremely Low Birth Weight Infants: A Retrospective Cohort Study Open Access

    Taniguchi, A; Nishida, K; Suzuki, T; Kataoka, E; Fujishiro, N; Kato, E; Yamamoto, H; Takemoto, K; Ito, M; Hayashi, S; Sugiyama, Y; Maeda, T; Takahashi, Y; Sato, Y

    NEONATOLOGY   121 巻 ( 2 ) 頁: 195 - 202   2024年3月

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    記述言語:英語   出版者・発行元:Neonatology  

    Introduction: The effects of hydrocortisone (HDC) administration to extremely low birth weight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental outcomes in ELBW infants. Methods: This study was a retrospective cohort study conducted in eight centers in Japan. The subjects of this study were ELBW infants born between April 2015 and March 2017. The association between postnatal total HDC dosage up to 36 weeks postmenstrual age and the developmental quotient (DQ) at 3 years of age was examined. Multiple linear regression evaluated the association, adjusting for weeks of gestation, birth weight, and the presence of bronchopulmonary dysplasia, late-onset circulatory collapse, intracranial hemorrhage, necrotizing enterocolitis, and sepsis. Results: This study included 218 ELBW infants, of whom 144 underwent a developmental test at 3 years of age. Simple linear regression analysis revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: −2.65, 95% CI: −3.73, −1.57). Multiple linear regression analysis adjusted for the presence of bronchopulmonary dysplasia and late-onset circulatory collapse also revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: −2.66, 95% CI: −3.89, −1.42). Conclusion: Higher total HDC dosage up to 36 weeks postmenstrual age in ELBW infants was associated with impaired neurodevelopmental outcomes. Although HDC is often needed in the treatment of ELBW infants, clinicians should be aware that an increased dose of HDC may be associated with impaired neurodevelopmental outcomes.

    DOI: 10.1159/000534934

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  3. Vascular perforation of umbilical venous catheter and awaiting it to be shallow

    Taniguchi, A; Hayakawa, M; Sato, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 3 ) 頁: 635 - 638   2023年8月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    The patient was a boy born at 23 weeks and 0 days of gestation weighed 401 g at birth. For treatment, an umbilical venous catheter was placed but the catheter perforated a blood vessel. We thought that prompt removal of the catheter would lead to massive bleeding, so we kept the catheter in place at the umbilicus, waited for weight gain, and removed it after confirming that the catheter tip had spontaneously become shallow and was in the umbilical vein. This procedure allowed us to handle the patient without major problems.

    DOI: 10.18999/nagjms.85.3.635

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  4. Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants Open Access

    Taniguchi, A; Hayakawa, M; Kataoka, E; Fujishiro, N; Sato, Y

    JOURNAL OF CLINICAL MEDICINE   11 巻 ( 3 )   2022年2月

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    記述言語:英語   出版者・発行元:Journal of Clinical Medicine  

    The aim of this study is to investigate whether it is possible to detect future behavioral and emotional problems in extremely low-birth-weight infants by evaluating the neonatal head magnetic resonance imaging (MRI) using a scoring system. This study included 62 extremely low-birth-weight infants born between April 2015 and March 2017 and those who had undergone MRI at 36 to 42 weeks of gestation. These subjects were administered with the Strength and Difficulties Questionnaire (SDQ) at age 4–5, and the patients who responded to the questionnaire were included in the study. A positive correlation was observed between the Global Brain Abnormality Score and Total Difficulties Score of the SDQ (r = 0.26, p = 0.038). However, no significant difference was observed between the median Global Brain Abnormality Score of the normal and borderline-range group and the Total Difficulties Score of the clinical-range group (p = 0.51). This study demonstrated the relationship between the MRI findings in the newborn period and the emotional and behavioral problems in early childhood, but it is not clinically useful as a predictive marker.

    DOI: 10.3390/jcm11030772

    Open Access

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  5. Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children Open Access

    Taniguchi, A; Kawada, J; Go, K; Fujishiro, N; Hosokawa, Y; Maki, Y; Sugiyama, Y; Suzuki, M; Tsuji, T; Hoshino, S; Muramatsu, H; Kidokoro, H; Kinoshita, F; Hirakawa, A; Takahashi, Y; Sato, Y; Natsume, J; Yamakawa, K; Okumura, A; Kato, T; Nagai, N; Moriyama, M; Miyajima, Y; Yamamori, K; Shibata, M; Hasegawa, M; Shinohara, O; Nishimura, N; Aoshima, T; Morishita, M; Nomura, Y; Kuraishi, K

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   72 巻 ( 4 ) 頁: 237 - 242   2019年7月

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    記述言語:英語   出版者・発行元:Japanese Journal of Infectious Diseases  

    Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory tract infection in children, and clinical manifestations of these virus infections are considered similar. To investigate the differences in clinical characteristics between HMPV and RSV infections in young children, we prospectively enrolled children < 3 years old who required hospitalization with acute respiratory tract infection due to HMPV or RSV at 10 hospitals in Japan. We enrolled 48 children with HMPV infection and 141 with RSV infection. Patients with HMPV infection were older than those with RSV infection. High-grade fever was more frequently observed in patients with HMPV infection, whereas no significant differences in respiratory symptoms were apparent. Abnormal serum lactate dehydrogenase values and consolidation shadows on chest X-ray were more frequently observed in patients with HMPV infection. During hospitalization, nasal mucus suction was more frequently required in patients with RSV infection. On the other hand, β2-adrenergic agonists, corticosteroids, and leukotriene receptor antagonists were more frequently used in patients with HMPV infection. These findings suggest that HMPV and RSV infections show similar respiratory symptoms, but HMPV infection is more likely to lead to the development of pneumonia, at least among hospitalized young children.

    DOI: 10.7883/yoken.JJID.2018.480

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    CiNii Research

  6. Inhaled procaterol for the treatment of transient tachypnea of the newborn

    Taniguchi, A; Hayakawa, M; Matsusawa, M; Hayashi, S

    PEDIATRICS INTERNATIONAL   60 巻 ( 11 ) 頁: 1014 - 1019   2018年11月

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    記述言語:英語   出版者・発行元:Pediatrics International  

    Background: Transient tachypnea of the newborn (TTN) is a respiratory disorder that results from inadequate or delayed clearance of fetal lung fluid following delivery. At present, supportive care is generally practiced for the treatment of TTN. In this study, we focused on inhaled beta-agonists for the treatment of TTN, and the aim was to verify the efficacy and the safety of inhaled procaterol for the treatment of TTN. Methods: Inhaled procaterol or normal saline solution was administered to infants. Respiratory rate and mixed venous carbon dioxide (PvCO<inf>2</inf>) were evaluated as the primary outcomes. The duration of hospitalization, duration of oxygen therapy, and changes in respiratory support were evaluated as secondary outcomes. Results: Thirty-seven neonates diagnosed with TTN were randomly assigned to the procaterol group (n = 18) or the placebo group (n = 19). There were no differences in PvCO<inf>2</inf> or respiratory rate between the two groups before and after intervention. Median duration of oxygen therapy (3 days; IQR, 3–6.5 days vs 2 days, IQR, 2–4.75 days; P = 0.13) and of hospitalization (15 days; IQR, 11.25–20 days vs 11 days, IQR, 8–15.5 days; P = 0.14) were not significantly different. Conclusions: Inhaled procaterol was not effective for the treatment of TTN.

    DOI: 10.1111/ped.13699

    Web of Science

    Scopus

    PubMed

  7. Pleural effusion with rib fractures in infant.

    Taniguchi A, Maeda T, Tachibana T

    Clinical case reports   6 巻 ( 6 ) 頁: 1185 - 1186   2018年6月

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▼全件表示

書籍等出版物 1

  1. 周産期の薬

    谷口顕信( 担当: 分担執筆 ,  範囲: 脳神経系疾患 新生児発作)

    東京医学社  2020年12月 

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    総ページ数:731   担当ページ:4   記述言語:日本語 著書種別:学術書

講演・口頭発表等 1

  1. Total Hydrocortisone Dosage in the Neonatal Period Is Related to Developmental Quotient Deterioration in Extremely Low Birth Weight Infants: a retrospective cohort study 国際共著

    Akinobu Taniguchi

    the 22nd Congress of the Federation of Asian and Oceania Perinatal Societies  2023年10月9日 

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    開催年月日: 2023年10月

    記述言語:英語   会議種別:ポスター発表  

    開催地:Tokyo   国名:日本国  

科研費 1

  1. 幹細胞を用いた小腸再生を標的とした新生児壊死性腸炎の治療法の開発

    研究課題/研究課題番号:20K16888  2020年4月 - 2023年3月

    科学研究費助成事業  若手研究

    谷口 顕信

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    担当区分:研究代表者 

    配分額:3640000円 ( 直接経費:2800000円 、 間接経費:840000円 )

    新生児壊死性腸炎(NEC)は、早産・極低出生体重児の頻度の高い合併症の一つである。新生児医療の進歩により早産児の死亡率は格段に低下したが、NECを合併した場合の死亡率は約20-30%と依然として高い。重症例では、根治治療である外科的手術を行うが、全身が未熟な早産児には侵襲が高いため、より安全で簡便な新規治療法の開発は喫緊の課題である。幹細胞による治療はヒトにおいても腸管疾患で応用されつつあるが、新生児領域における検討は未だに報告は少ない。我々は、NECモデルラットに対してA細胞を投与し、組織学的解析ならびに先行研究で同定したNECに伴い発現変動を示すタンパク質の発現を評価する。
    新生児壊死性腸炎(NEC)の治療において、幹細胞の投与が有望な治療法となる可能性がある。この研究では、A細胞を使用した新規治療法の開発を目指し、新生児NECモデルを作製し、A細胞の効果を検討した。しかしながら、A細胞の投与では、治療効果を見出せなかったため、B細胞の静脈内投与、腹腔内投与による効果を検討した。B細胞の両投与方法においても、体重増加、死亡率、組織学的評価のどの評価においても差を見出すことができなかった。
    本研究において、これまで、外科的でしか根治治療がなかった新生児NECに対して、外科的手技よりも侵襲が少なくより簡便な幹細胞投与が有効であると示すべく、二つの細胞で検討したが、効果を見出すことができなかった。
    しかしながら、モデルの確立、投与方法、評価方法の確立ができたため、今後、細胞腫の変更、また、投与細胞数や投与方法の変更などで、効果のある方法を見出していける可能性がある。