2022/11/01 更新

写真a

タニグチ アキノブ
谷口 顕信
TANIGUCHI Akinobu
所属
医学部附属病院 病院戦略室 病院助教
職名
病院助教

学位 1

  1. 学士(医学) ( 名古屋大学 ) 

現在の研究課題とSDGs 1

  1. 新生児医療に関する研究

 

論文 4

  1. Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants

    Taniguchi Akinobu, Hayakawa Masahiro, Kataoka Erina, Fujishiro Naozumi, Sato Yoshiaki

    JOURNAL OF CLINICAL MEDICINE   11 巻 ( 3 )   2022年2月

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    記述言語:日本語   出版者・発行元:Journal of Clinical Medicine  

    The aim of this study is to investigate whether it is possible to detect future behavioral and emotional problems in extremely low-birth-weight infants by evaluating the neonatal head magnetic resonance imaging (MRI) using a scoring system. This study included 62 extremely low-birth-weight infants born between April 2015 and March 2017 and those who had undergone MRI at 36 to 42 weeks of gestation. These subjects were administered with the Strength and Difficulties Questionnaire (SDQ) at age 4–5, and the patients who responded to the questionnaire were included in the study. A positive correlation was observed between the Global Brain Abnormality Score and Total Difficulties Score of the SDQ (r = 0.26, p = 0.038). However, no significant difference was observed between the median Global Brain Abnormality Score of the normal and borderline-range group and the Total Difficulties Score of the clinical-range group (p = 0.51). This study demonstrated the relationship between the MRI findings in the newborn period and the emotional and behavioral problems in early childhood, but it is not clinically useful as a predictive marker.

    DOI: 10.3390/jcm11030772

    Web of Science

    Scopus

    PubMed

  2. Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children

    Taniguchi Akinobu, Kawada Jun-ichi, Go Kiyotaka, Fujishiro Naozumi, Hosokawa Yosuke, Maki Yuki, Sugiyama Yuichiro, Suzuki Michio, Tsuji Takeshi, Hoshino Shin, Muramatsu Hideki, Kidokoro Hiroyuki, Kinoshita Fumie, Hirakawa Akihiro, Takahashi Yoshiyuki, Sato Yoshiaki, Natsume Jun, Yamakawa Kiyoshi, Okumura Akihisa, Kato Toru, Nagai Noriko, Moriyama Miyako, Miyajima Yuji, Yamamori Kazuki, Shibata Motohiro, Hasegawa Masayuki, Shinohara Osamu, Nishimura Naoko, Aoshima Tsutomu, Morishita Masashi, Nomura Yoji, Kuraishi Kenji

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   72 巻 ( 4 ) 頁: 237 - 242   2019年7月

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    出版者・発行元:Japanese Journal of Infectious Diseases  

    <p>Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory tract infection in children, and clinical manifestations of these virus infections are considered similar. To investigate the differences in clinical characteristics between HMPV and RSV infections in young children, we prospectively enrolled children < 3 years old who required hospitalization with acute respiratory tract infection due to HMPV or RSV at 10 hospitals in Japan. We enrolled 48 children with HMPV infection and 141 with RSV infection. Patients with HMPV infection were older than those with RSV infection. High-grade fever was more frequently observed in patients with HMPV infection, whereas no significant differences in respiratory symptoms were apparent. Abnormal serum lactate dehydrogenase values and consolidation shadows on chest X-ray were more frequently observed in patients with HMPV infection. During hospitalization, nasal mucus suction was more frequently required in patients with RSV infection. On the other hand, β2-adrenergic agonists, corticosteroids, and leukotriene receptor antagonists were more frequently used in patients with HMPV infection. These findings suggest that HMPV and RSV infections show similar respiratory symptoms, but HMPV infection is more likely to lead to the development of pneumonia, at least among hospitalized young children.</p>

    DOI: 10.7883/yoken.JJID.2018.480

    Web of Science

    Scopus

    PubMed

  3. Inhaled procaterol for the treatment of transient tachypnea of the newborn

    Taniguchi Akinobu, Hayakawa Masahiro, Matsusawa Maiko, Hayashi Seiji

    PEDIATRICS INTERNATIONAL   60 巻 ( 11 ) 頁: 1014 - 1019   2018年11月

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    出版者・発行元:Pediatrics International  

    DOI: 10.1111/ped.13699

    Web of Science

    Scopus

    PubMed

  4. Pleural effusion with rib fractures in infant.

    Taniguchi A, Maeda T, Tachibana T

    Clinical case reports   6 巻 ( 6 ) 頁: 1185 - 1186   2018年6月

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書籍等出版物 1

  1. 周産期の薬

    谷口顕信( 担当: 分担執筆 ,  範囲: 脳神経系疾患 新生児発作)

    東京医学社  2020年12月 

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    総ページ数:731   担当ページ:4   記述言語:日本語 著書種別:学術書

科研費 1

  1. 幹細胞を用いた小腸再生を標的とした新生児壊死性腸炎の治療法の開発

    研究課題/研究課題番号:20K16888  2020年4月 - 2023年3月

    若手研究

    谷口 顕信

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    担当区分:研究代表者 

    配分額:3640000円 ( 直接経費:2800000円 、 間接経費:840000円 )

    新生児壊死性腸炎(NEC)は、早産・極低出生体重児の頻度の高い合併症の一つである。新生児医療の進歩により早産児の死亡率は格段に低下したが、NECを合併した場合の死亡率は約20-30%と依然として高い。重症例では、根治治療である外科的手術を行うが、全身が未熟な早産児には侵襲が高いため、より安全で簡便な新規治療法の開発は喫緊の課題である。幹細胞による治療はヒトにおいても腸管疾患で応用されつつあるが、新生児領域における検討は未だに報告は少ない。我々は、NECモデルラットに対してA細胞を投与し、組織学的解析ならびに先行研究で同定したNECに伴い発現変動を示すタンパク質の発現を評価する。