Faculty Profiles - NAKASHIMA Hiroaki

Papers - NAKASHIMA Hiroaki

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Poor spinal alignment in females with obesity: The Yakumo study Open Access

Ando, K; Kobayashi, K; Nakashima, H; Machino, M; Ito, S; Kanbara, S; Inoue, T; Hasegawa, Y; Imagama, S

JOURNAL OF ORTHOPAEDICS Vol. 21 page： 512 - 516 2020.9

Language：English Publisher：Journal of Orthopaedics

Objective: The goal of this prospective study was prospectively to investigate the relationship between obesity and spinal sagittal alignment. Methods: 286 were referred for orthopedic evaluation. Differences in spinal parameters among these groups and between males and females were evaluated. Results: Obese subjects had significantly higher C2S, CPA, CTPA, PI-LL, and lower cervical lordosis, L4S1, lumbar lordosis, and sacral slope. In multivariate logistic regression analysis adjusted for age in females, CTPA was identified as the only independent and significant factor associated with obesity. Conclusions: Obesity in females has significant relationships with spinal sagittal alignment and results in poorer physical QOL.

DOI： 10.1016/j.jor.2020.09.006

Web of Science

Scopus

PubMed

Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model Reviewed Open Access

Kanbara, S; Ohkawara, B; Nakashima, H; Ohta, K; Koshimizu, H; Inoue, T; Tomita, H; Ito, M; Masuda, A; Ishiguro, N; Imagama, S; Ohno, K

SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 13138 2020.8

Language：English Publisher：Scientific Reports

Cervical spondylotic myelopathy (CSM) is caused by chronic compression of the spinal cord and is the most common cause of myelopathy in adults. No drug is currently available to mitigate CSM. Herein, we made a rat model of CSM by epidurally implanting an expanding water-absorbent polymer underneath the laminae compress the spinal cord. The CSM rats exhibited progressive motor impairments recapitulating human CSM. CSM rats had loss of spinal motor neurons, and increased lipid peroxidation in the spinal cord. Zonisamide (ZNS) is clinically used for epilepsy and Parkinson's disease. We previously reported that ZNS protected primary spinal motor neurons against oxidative stress. We thus examined the effects of ZNS on our rat CSM model. CSM rats with daily intragastric administration of 0.5% methylcellulose (n = 11) and ZNS (30 mg/kg/day) in 0.5% methylcellulose (n = 11). Oral administration of ZNS ameliorated the progression of motor impairments, spared the number of spinal motor neurons, and preserved myelination of the pyramidal tracts. In addition, ZNS increased gene expressions of cystine/glutamate exchange transporter (xCT) and metallothionein 2A in the spinal cord in CSM rats, and also in the primary astrocytes. ZNS increased the glutathione (GSH) level in the spinal motor neurons of CSM rats. ZNS potentially ameliorates loss of the spinal motor neurons and demyelination of the pyramidal tracts in patients with CSM.

DOI： 10.1038/s41598-020-70068-0

Reoperation for Late Neurological Deterioration After Laminoplasty in Individuals with Degenerative Cervical Myelopathy: Comparison of Cases of Cervical Spondylosis and Ossification of the Posterior Longitudinal Ligament. Reviewed

Nakashima H, Kanemura T, Satake K, Ito K, Ouchida J, Morita D, Ando K, Kobayashi K, Ishiguro N, Imagama S

Spine Vol. 45 ( 15 ) page： E909 - E916 2020.8

Lateral approach corpectomy and reconstruction after anterior longitudinal ligament release in cases with fixed kyphosis: A technical note and a preliminary case series. Reviewed

Nakashima H, Kanemura T, Satake K, Ito K, Tanaka S, Segi N, Ouchida J, Ando K, Kobayashi K, Ishiguro N, Imagama S

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Vol. 78 page： 164 - 169 2020.8

Risk Factors for Neuropathic Pain in Middle-Aged and Elderly People: A Five-Year Longitudinal Cohort in the Yakumo Study. Reviewed

Imagama S, Ando K, Kobayashi K, Nakashima H, Seki T, Hamada T, Machino M, Ota K, Tanaka S, Morozumi M, Kanbara S, Ito S, Ishiguro N, Hasegawa Y

Pain medicine (Malden, Mass.) Vol. 21 ( 8 ) page： 1604 - 1610 2020.8

Dynapenia and physical performance in community-dwelling elderly people in Japan Reviewed Open Access

Kobayashi, K; Imagama, S; Ando, K; Nakashima, H; Machino, M; Morozumi, M; Kanbara, S; Ito, S; Inoue, T; Yamaguchi, H; Ishiguro, N; Hasegawa, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 3 ) page： 415 - 424 2020.8

Language：English Publisher：Nagoya Journal of Medical Science

Aging of society has increased the incidence of physical disability. The goal of this study was to examine the physical ability of elderly people classified as having sarcopenia, presarcopenia, or dynapenia (a low muscle function without low muscle mass) in a community in Japan. The subjects were volunteers aged >60 years who were participants in a health checkup in Yakumo, Hokkaido and were in good general health. Demographic data were collected and physical performance tests were performed to measure grip strength, walking speed, back muscle strength, maximum stride length, and 3-m timed-up-and-go (3m TUG) time. A measurement of skeletal muscle mass was used as a basis for calculating the appendicular skeletal muscle index (aSMI). The rates of sarcopenia, presarcopenia, and dynapenia were 10%, 22%, and 8% in males (n=101, age 69.7±5.4 years), and 19%, 23%, and 13% in females (n=112, 68.5±5.9 years). Body mass index in subjects with dynapenia was significantly higher compared to that in subjects with sarcopenia and presarcopenia (p<0.01). Back muscle strength, maximum stride length and 3m TUG were similar in dynapenia and sarcopenia, but differed significantly with those in presarcopenia in both males and females without the influence of age (p<0.05). Further studies are needed to evaluate the benefits of dynapenia intervention programs and to explore the underlying pathophysiology of dynapenia.

DOI： 10.18999/nagjms.82.3.415

Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study Reviewed Open Access

Nakashima, H; Ando, K; Kobayashi, K; Seki, T; Ishizuka, S; Fujii, R; Takegami, Y; Yamada, H; Ando, Y; Suzuki, K; Hasegawa, Y; Imagama, S

BIOMED RESEARCH INTERNATIONAL Vol. 2020 page： 5047243 2020.7

Language：English Publisher：Biomed Research International

Osteoporosis is a disease characterized by deterioration of bone tissue and mass, with an increasing global prevalence. Therefore, the discovery of biomarkers for osteoporosis would help to guide appropriate treatment. Circulating microRNAs (miRNAs) have become increasingly recognized as biomarkers for detecting diseases. However, few studies have investigated the association of circulating miRNA with osteoporosis in the general population. The aim of this study was to identify miRNA associated with osteoporosis in a general resident health check-up for potential use as an osteoporosis biomarker. We conducted a cross-sectional study as part of a health check-up program and recruited 352 volunteers (139 men, 213 women, mean age 64.1±9.6 years). Osteoporosis was diagnosed according to the WHO classification. Twenty-two candidate microRNAs were screened through real-time quantitative PCR, and miRNAs associated with osteoporosis were analyzed using logistic regression analysis including other risk factors. In total, 95 females and 30 males were diagnosed with osteoporosis with bone mineral density tests (BMD: T-score<-2.5). We found that miR195 was significantly lower in females, while miR150 and miR222 were significantly higher in males. The results of the logistic regression analysis indicated that in females, higher age and lower miR195 (odds ratio: 0.45, 95% confidential interval: 0.03-0.98) were significant risk factors for lower BMD, while the presence of a smoking habit and lower miR150 (odds ratio: 1.35, 95% confidential interval: 1.02-1.79) were significant risk factors for osteoporosis. Serum levels of miR195 and miR150 are independently associated with low bone mineral density in females and males, respectively.

DOI： 10.1155/2020/5047243

特集脊椎手術-前方か後方か? 胸腰椎移行部破裂骨折に対する前方除圧椎体置換術

中島宏彰, 今釜史郎, 安藤圭, 小林和克, 町野正明, 金村徳相

臨床整形外科 Vol. 55 ( 7 ) page： 811 - 817 2020.7

Prognostic Factors in the New Katagiri Scoring System After Palliative Surgery for Spinal Metastasis. Reviewed

Kobayashi K, Ando K, Nakashima H, Sato K, Kanemura T, Yoshihara H, Hirasawa A, Kato F, Ishiguro N, Imagama S

Spine Vol. 45 ( 13 ) page： E813 - E819 2020.7

Locomotive syndrome and the power spectral characteristics of body sway Reviewed

Tanaka Satoshi, Ando Kei, Kobayashi Kazuyoshi, Nakashima Hiroaki, Seki Taisuke, Ishizuka Shinya, Machino Masaaki, Kanbara Shunsuke, Ito Sadayuki, Kanemura Tokumi, Ishiguro Naoki, Hasegawa Yukiharu, Imagama Shiro

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 20 ( 7 ) page： 691 - 696 2020.7

Superficial Siderosis With Verrucous Vegetation Around a Dural Defect Confirmed by Intraoperative Ultrasonography. Reviewed Open Access

Machino M, Imagama S, Ando K, Kobayashi K, Nakashima H, Kanbara S, Ito S, Ishiguro N

Journal of medical cases Vol. 11 ( 7 ) page： 192 - 195 2020.7

Language：English Publisher：Journal of Medical Cases

Superficial siderosis (SS) of the central nervous system (CNS) is a rare disease caused by repeated hemorrhages in the subarachnoid space. We describe surgical treatment of an SS case in which a dural defect with verrucous vegetation in the spinal canal was detected by intraoperative ultrasonography (US). After laminectomy, intraoperative US imaging confirmed verrucous vegetation and epidural fluid collection around the ventral dural defect before incision of the posterior dura mater. As intraoperative US also showed a dural defect at the ventral and right sides of the spinal cord, the posterior dural incision was made in a manner that was slightly more right lateral than standard midline. The ventral dural defect was repaired by direct sutures. After repair, intraoperative US imaging confirmed dural hole closure, removal of vegetation and resolution of the collected fluid. Dural closure was successful and symptoms partially improved despite the patient’s long history of SS. Intraoperative US can help surgeons make decisions about precise dural incision before repair. Intraoperative US is useful for detecting the level of dural defect and verrucous vegetation before repair and confirming closure of the dural defect, successful removal of vegetation and resolution of fluid collection after repair.

DOI： 10.14740/jmc3495

Open Access

Scopus

PubMed

Indirect Decompression Using Lateral Lumbar Interbody Fusion for Restenosis after an Initial Decompression Surgery. Open Access

Nakashima H, Kanemura T, Satake K, Ito K, Ishikawa Y, Ouchida J, Segi N, Yamaguchi H, Imagama S

Asian spine journal Vol. 14 ( 3 ) page： 305 - 311 2020.6

Simultaneous single-position lateral interbody fusion and percutaneous pedicle screw fixation using O-arm-based navigation reduces the occupancy time of the operating room Reviewed

Ouchida Jun, Kanemura Tokumi, Satake Kotaro, Nakashima Hiroaki, Ishikawa Yoshimoto, Imagama Shiro

EUROPEAN SPINE JOURNAL Vol. 29 ( 6 ) page： 1277 - 1286 2020.6

Higher extracellular water-to-total body water ratio more strongly reflects the locomotive syndrome risk and frailty than sarcopenia Reviewed

Tanaka Satoshi, Ando Kei, Kobayashi Kazuyoshi, Nakashima Hiroaki, Seki Taisuke, Ishizuka Shinya, Machino Masaaki, Morozumi Masayoshi, Kanbara Shunsuke, Ito Sadayuki, Inoue Taro, Kanemura Tokumi, Ishiguro Naoki, Hasegawa Yukiharu, Imagama Shiro

ARCHIVES OF GERONTOLOGY AND GERIATRICS Vol. 88 page： 104042 2020.5

Postoperative iatrogenic spinal cord herniation: three case reports with a literature review Reviewed Open Access

Nakashima Hiroaki, Ishikawa Yoshimoto, Kato Fumihiko, Kanemura Tokumi, Shinjo Ryuichi, Ando Kei, Kobayashi Kazuyoshi, Ishiguro Naoki, Imagama Shiro

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 2 ) page： 383 - 389 2020.5

The Surgical Treatment for Occipito-atlantoaxial Rotatory Fixation: a Case Report

Kagami Yujiro, Ouchida Jun, Nakashima Hiroaki, Satake Kotaro, Ito Kenyu, Ishikawa Yoshimoto, Imagama Shiro, Kanemura Tokumi

Journal of Spine Research Vol. 11 ( 4 ) page： 779 - 782 2020.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Spine Surgery and Related Research

<p>A 10-year-old boy complaining of neck pain without any inducement was referred to our hospital. Images at the first visit showed an atlantoaxial rotatory fixation (AARF). He received conservative treatment for 14 months with a cervical collar, Glisson traction and halo vest fixation after manual reduction under general anesthesia. However, residual rotational position and cervical pain recurred. Finally, he required surgical intervention with posterior C1-2 fixation. An atlantoaxial rotation with O-C1 joint lesion (OAARF) may result in worse treatment outcome as conservative treatment compared to AARF. It is necessary to evaluate the pathological condition at an early stage of OAARF and consider decision making including the surgical treatment.</p>

DOI： 10.34371/jspineres.2020-0411

CiNii Research

The Prevalence and Risk Factors for S2 Alar-Iliac Screw Loosening with a Minimum 2-Year Follow-up Reviewed Open Access

Nakashima Hiroaki, Kanemura Tokumi, Satake Kotaro, Ito Kenyu, Ishikawa Yoshimoto, Ouchida Jun, Segi Naoki, Yamaguchi Hidetoshi, Imagama Shiro

ASIAN SPINE JOURNAL Vol. 14 ( 2 ) page： 177 - 184 2020.4

特集頚椎を含めたグローバルアライメント頭蓋から足部までの全身アライメント-人種間の違いと成人脊柱変形手術における矯正目標

中島宏彰, 今釜史郎, 安藤圭, 小林和克, 大内田隼, 金村徳相

臨床整形外科 Vol. 55 ( 3 ) page： 247 - 252 2020.3

Differences of lumbopelvic sagittal parameters among community-dwelling middle-age and elderly individuals: Relations with locomotor physical function Reviewed

Machino Masaaki, Ando Kei, Kobayashi Kazuyoshi, Nakashima Hiroaki, Morozumi Masayoshi, Tanaka Satoshi, Kanbara Shunsuke, Ito Sadayuki, Seki Taisuke, Ishizuka Shinya, Ishiguro Naoki, Hasegawa Yukiharu, Imagama Shiro

JOURNAL OF CLINICAL NEUROSCIENCE Vol. 73 page： 80 - 84 2020.3

特集脊柱靭帯骨化症UP TO DATE 胸椎後縦靭帯骨化症の手術治療-最近の進歩

今釜史郎, 安藤圭, 小林和克, 中島宏彰, 石黒直樹, 松山幸弘, 松本守雄, 川口善治, 大川淳

脊椎脊髄ジャーナル Vol. 33 ( 2 ) page： 119 - 125 2020.2

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Papers - NAKASHIMA Hiroaki