Updated on 2022/09/29

写真a

 
IMAIZUMI Takahiro
 
Organization
Nagoya University Hospital Date Center Designated assistant professor
Title
Designated assistant professor
Profile
慢性腎臓病臨床疫学を専門にしています。
External link

Degree 1

  1. 博士(医学) ( 2017.3   名古屋大学 ) 

Research Interests 4

  1. Chronic Kidney Disease

  2. Clinical Epidemiology

  3. Real-world Evidence

  4. Extended-hours Hemodialysis

Research Areas 2

  1. Life Science / General internal medicine  / Clinical Epidemiology

  2. Life Science / Nephrology  / Chronic Kidney Disease

Research History 2

  1. Nagoya University   Nagoya University Hospital Date Center   Designated assistant professor

    2019.4

  2. University of Pennsylvania   Department of Biostatistics, Epidemiology, and Informatics   Researcher

    2017.7 - 2019.3

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    Country:United States

 

Papers 42

  1. Clinical parameter-based prediction of DNA methylation classification generates a prediction model of prognosis in patients with juvenile myelomonocytic leukemia.

    Imaizumi T, Meyer J, Wakamatsu M, Kitazawa H, Murakami N, Okuno Y, Yoshida T, Sajiki D, Hama A, Kojima S, Takahashi Y, Loh M, Stieglitz E, Muramatsu H

    Scientific reports   Vol. 12 ( 1 ) page: 14753   2022.8

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    Language:English   Publisher:Scientific Reports  

    Juvenile myelomonocytic leukemia (JMML) is a rare heterogeneous hematological malignancy of early childhood characterized by causative RAS pathway mutations. Classifying patients with JMML using global DNA methylation profiles is useful for risk stratification. We implemented machine learning algorithms (decision tree, support vector machine, and naïve Bayes) to produce a DNA methylation-based classification according to recent international consensus definitions using a well-characterized pooled cohort of patients with JMML (n = 128). DNA methylation was originally categorized into three subgroups: high methylation (HM), intermediate methylation (IM), and low methylation (LM), which is a trichotomized classification. We also dichotomized the subgroups as HM/IM and LM. The decision tree model showed high concordances with 450k-based methylation [82.3% (106/128) for the dichotomized and 83.6% (107/128) for the trichotomized subgroups, respectively]. With an independent cohort (n = 72), we confirmed that these models using both the dichotomized and trichotomized classifications were highly predictive of survival. Our study demonstrates that machine learning algorithms can generate clinical parameter-based models that predict the survival outcomes of patients with JMML and high accuracy. These models enabled us to rapidly and effectively identify candidates for augmented treatment following diagnosis.

    DOI: 10.1038/s41598-022-18733-4

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  2. Reasons and risk factors for discontinuation of treatment with any biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A long-term observational study

    Terabe Kenya, Takahashi Nobunori, Asai Shuji, Hirano Yuji, Kanayama Yasuhide, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Ishikawa Hisato, Hanabayashi Masahiro, Hattori Yosuke, Suzuki Mochihito, Kishimoto Kenji, Ohashi Yoshifumi, Imaizumi Takahiro, Imagama Shiro, Kojima Toshihisa

    MODERN RHEUMATOLOGY     2022.8

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  3. Risk factors for unplanned removal of central venous catheters in hospitalized children with hematological and oncological disorders

    Miyagishima Moe, Hamada Motoharu, Hirayama Yuji, Muramatsu Hideki, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Imaizumi Takahiro, Nakatochi Masahiro, Kamei Michi, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 116 ( 2 ) page: 288 - 294   2022.8

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    Language:Japanese   Publisher:International Journal of Hematology  

    Central venous catheters (CVCs) are essential devices in the treatment of pediatric patients with hematological and oncological disorders; however, the most suitable type of CVC for these patients remains unclear. We retrospectively compared risk factors for unplanned removal of two commonly used CVCs, peripherally inserted central catheters (PICCs) and tunneled CVCs, to propose which is the better device. We followed 89 patients fitted with a tunneled CVC (total 21,395 catheter-days) and 84 fitted with a PICC (total 9177 catheter-days) between January 1, 2013 and December 31, 2015, until catheter removal. Patients with a PICC had a significantly higher 3-month cumulative incidence of catheter occlusion (5.2% vs. 0%, p = 4.08 × 10−3) and total unplanned removals (29.0% vs. 6.9%, p = 0.0316) than those with tunneled CVCs. However, the cumulative incidence of central line-associated bloodstream infection did not differ significantly by CVC type. Multivariable analysis identified younger age (< 2 years) [sub-distribution hazard ratio (SHR) 2.29; 95% confidence interval (CI) 1.27–4.14] and PICC (SHR 2.73; 95% CI 1.48–5.02) as independent risk factors for unplanned removal. Thus, our results suggest that tunneled CVCs are preferable in pediatric patients with hematological and oncological disorders requiring long-term, intensive treatment.

    DOI: 10.1007/s12185-022-03346-4

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  4. Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan

    Tanaka Akio, Yamaguchi Makoto, Ishimoto Takuji, Katsuno Takayuki, Nobata Hironobu, Iwagaitsu Shiho, Sugiyama Hirokazu, Kinashi Hiroshi, Banno Shogo, Imaizumi Takahiro, Ando Masahiko, Kubo Yoko, Ito Yasuhiko

    NUTRITION JOURNAL   Vol. 21 ( 1 ) page: 31   2022.5

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    Language:Japanese   Publisher:Nutrition Journal  

    Background: The difference in the clinical impact of alcohol consumption on kidney function based on sex remains to be elucidated. This study aimed to assess the association between the dose of alcohol consumption and the incidence of proteinuria and chronic kidney disease stratified by sex. Methods: This retrospective cohort study included 26,788 workers (19,702 men and 7086 women) with normal renal function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) at annual health examinations between January 2010 and March 2015 in Japan. The main exposure was alcohol consumption. The primary outcomes were the incidence of proteinuria (dipstick urinary protein ≥ 1) and incidence of low estimated glomerular filtration rate (eGFR; rate < 60 mL/min per 1.73 m2; decreased from the baseline eGFR by 25%). Results: During a median observational period of 4 years (interquartile range: 2–6), 1993 (10.1%) men and 462 (6.5%) women developed proteinuria, whereas 667 (3.4%) men and 255 (3.6%) women developed low eGFR. After adjustment for clinically relevant factors using a Cox proportional hazards model, alcohol consumption of ≥ 46 g/day in females was significantly associated with the incidence of proteinuria (hazard ratio, 1.57; 95% confidence interval, 1.10–2.26) and low eGFR (hazard ratio, 1.62; 95% confidence interval, 1.04–2.53). However, no significant association between alcohol consumption and primary outcomes was observed in men. Conclusions: In conclusion, daily higher alcohol consumption was significantly associated with a higher incidence of proteinuria and low eGFR among women. Women might be prone to high alcohol consumption with kidney dysfunction.

    DOI: 10.1186/s12937-022-00785-x

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  5. Biopsy-proven CKD etiology and outcomes: the Chronic Kidney Disease Japan Cohort (CKD-JAC) study

    Hamano Takayuki, Imaizumi Takahiro, Hasegawa Takeshi, Fujii Naohiko, Komaba Hirotaka, Ando Masahiko, Nangaku Masaomi, Nitta Kosaku, Hirakata Hideki, Isaka Yoshitaka, Wada Takashi, Maruyama Shoichi, Fukagawa Masafumi

    NEPHROLOGY DIALYSIS TRANSPLANTATION     2022.3

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  6. Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis

    Terabe Kenya, Takahashi Nobunori, Asai Shuji, Hirano Yuji, Kanayama Yasuhide, Yabe Yuichiro, Oguchi Takeshi, Fujibayashi Takayoshi, Ishikawa Hisato, Hanabayashi Masahiro, Hattori Yosuke, Suzuki Mochihito, Kishimoto Kenji, Ohashi Yoshifumi, Imaizumi Takahiro, Imagama Shiro, Kojima Toshihisa

    MODERN RHEUMATOLOGY     2022.3

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  7. Differences in Prognosis and Cardiac Function According to Required Percutaneous Mechanical Circulatory Support and Histological Findings in Patients With Fulminant Myocarditis: Insights From the CHANGE PUMP 2 Study

    Kondo Toru, Okumura Takahiro, Shibata Naoki, Imaizumi Takahiro, Dohi Kaoru, Izawa Hideo, Ohte Nobuyuki, Amano Tetsuya, Murohara Toyoaki

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 11 ( 4 ) page: e023719   2022.2

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    Language:Japanese   Publisher:Journal of the American Heart Association  

    BACKGROUND: Prognoses and long-term cardiac function of patients with fulminant myocarditis have not been fully elucidated. Therefore, we clarified the prognoses and long-term cardiac function according to required percutaneous mechanical circulatory support and histological findings among patients with fulminant myocarditis. METHODS AND RESULTS: We conducted a multicenter retrospective medical record review of 216 patients with fulminant my-ocarditis requiring percutaneous mechanical circulatory support. Sixty-one patients were treated with intra-aortic balloon pump or Impella alone, and 155 patients received veno-arterial extracorporeal membrane oxygenation and were treated with or without intra-aortic balloon pump or Impella. Histologically, 107 patients had lymphocytic myocarditis; 34, eosinophilic myocarditis; and 4, giant cell myocarditis. Freedom from composite end point (death, durable left ventricular assist device implantation, and heart transplantation) was 66% at 90 days, 62% at 1 year, and 57% at 6 years. Veno-arterial extracorporeal membrane oxygenation use was associated with poor prognosis in the multivariable analysis (hazard ratio [HR], 5.27; 95% CI, 1.60–17.36). The eosinophilic myocarditis subgroup showed better prognosis (HR, 0.28; 95% CI, 0.10– 0.80) compared with the lymphocytic myocarditis subgroup but not in the multivariable analysis. Ventricular tachycardia/ventricular fibrillation rhythm at admission, high C-reactive protein level, and no endomyocardial biopsy were also associated with poor prognosis. The left ventricular ejection fraction at 1 year was ≤50% in 16% of patients and was lower in patients with eosinophilic myocar-ditis (median: 57.9% [48.8– 65.0%]) than in those with lymphocytic myocarditis (65.0% [58.6– 68.7%]) (P=0.036). CONCLUSIONS: Patients with fulminant myocarditis who received veno-arterial extracorporeal membrane oxygenation had a poor prognosis. Long-term cardiac function was impaired in some patients, especially those with eosinophilic myocarditis.

    DOI: 10.1161/JAHA.121.023719

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  8. Current Status of Outpatient Oral Antimicrobial Prescription and the Influence of Antimicrobial Stewardship for Inpatients: A Repeated Cross-Sectional Study at a Japanese Community Hospital

    Tsuchimoto Daisuke, Morioka Hiroshi, Imaizumi Takahiro, Miyagawa Sawako, Yamamoto Masashi, Onishi Katsuhiro, Kuwabara Yukinori, Takada Kazuto, Watamoto Koichi

    Biological and Pharmaceutical Bulletin   Vol. 45 ( 9 ) page: 1340 - 1346   2022

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    Language:English   Publisher:The Pharmaceutical Society of Japan  

    <p>This study aimed to clarify the details of outpatient oral antimicrobial use (AMU) at a Japanese community hospital and investigate the influence of the current inpatient-based antimicrobial stewardship (AS) on outpatients. A repeated cross-sectional study was conducted in Komaki City Hospital. Data on patients, physicians, and oral antibiotics were collected in October 2013, 2016, and 2019, and appropriateness of treatment and surgical antimicrobial prophylaxis (SAP) was evaluated. The percentage of patients receiving oral antibiotics increased significantly from 4.7% in 2013 (345/7338) to 5.9% in 2019 (365/6146), and the overall number of antimicrobial prescriptions per 1000 outpatients increased from 51.8 in 2013 to 68.0 in 2019. Prescriptions for third-generation cephalosporins per 1000 outpatients decreased (from 21.4 to 6.3), whereas the number of prescriptions for penicillin (from 3.8 to 15.3), fluoroquinolones (from 7.0 to 13.2), and co-trimoxazole (from 5.0 to 15.8) increased from 2013 to 2019. The appropriate AMU for overall infections significantly increased (from 68.4% in 2013 to 83.7% in 2019). The choice and duration of AMU significantly improved for SAP. However, even in 2019, only 29.3% of patients received antibiotics before surgery. The improved selection of antibiotics on outpatient prescription may be due to the influence of AS—which is focused on inpatients—while prescriptions for fluoroquinolones and prophylactics also increased. The challenges of antimicrobial administration after surgeries were also highlighted.</p>

    DOI: 10.1248/bpb.b22-00309

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  9. Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease

    Hashimoto Yusaku, Imaizumi Takahiro, Kato Sawako, Yasuda Yoshinari, Ishimoto Takuji, Kawashiri Hiroaki, Hori Akihiro, Maruyama Shoichi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 20440   2021.10

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    Language:Japanese   Publisher:Scientific Reports  

    The influence of body mass or metabolic capacity on the association between alcohol consumption and lower risks of developing chronic kidney disease (CKD) is not fully elucidated. We examined whether the body mass index (BMI) affects the association between drinking alcohol and CKD. We defined CKD as an estimated glomerular filtration rate decline < 60 mL/min/1.73 m2 and/or positive proteinuria (≥ 1+). Participants were 11,175 Japanese individuals aged 40–74 years without baseline CKD who underwent annual health checkups. Daily alcohol consumption at baseline was estimated using a questionnaire, and the participants were categorized as “infrequent (occasionally, rarely or never),” “light (< 20 g/day),” “moderate (20–39 g/day),” and “heavy (≥ 40 g/day).” Over a median 5-year observation period, 936 participants developed CKD. Compared with infrequent drinkers, light drinkers were associated with low CKD risks; adjusted hazard ratios (95% confidence intervals) were 0.81 (0.69–0.95). Stratified by BMI (kg/m2), moderate drinkers in the low (< 18.5), normal (18.5–24.9), and high (≥ 25.0) BMI groups had adjusted hazard ratios (95% confidence intervals) of 3.44 (1.60–7.42), 0.75 (0.58–0.98), and 0.63 (0.39–1.04), respectively. Taken together, the association between alcohol consumption and CKD incidence was not the same in all the individuals, and individual tolerance must be considered.

    DOI: 10.1038/s41598-021-99222-y

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  10. All-cause and cardiovascular mortality in patients undergoing hemodialysis with aortic sclerosis and mild-to-moderate aortic stenosis: A cohort study

    Kurasawa Shimon, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Nishibori Nobuhiro, Kondo Toru, Kasuga Hirotake, Maruyama Shoichi

    ATHEROSCLEROSIS   Vol. 331   page: 12 - 19   2021.8

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    Language:Japanese   Publisher:Atherosclerosis  

    Background and aims: Mild-to-moderate aortic stenosis (AS) and aortic sclerosis, a precursor of AS, are associated with mortality in the general population; however, their association in patients undergoing hemodialysis with higher morbidity of AS is unknown. Thus, we investigated the mortality of aortic sclerosis and mild-to-moderate AS in patients undergoing hemodialysis. Methods: This was a retrospective multicenter cohort study of consecutive patients undergoing hemodialysis at nine dialysis facilities who underwent screening echocardiography between January 2008 and December 2019. We investigated the mortality of patients with aortic sclerosis or mild-to-moderate AS using multivariable Cox proportional hazards regression. Results: Among 1,878 patients undergoing hemodialysis, those with normal aortic valves, aortic sclerosis, mild AS, moderate AS, severe AS, and prosthetic aortic valves were 844 (45%), 793 (42%), 161 (8.6%), 38 (2.0%), 11 (0.6%), and 31 (1.7%), respectively. After excluding patients with severe AS and prosthetic aortic valves, we performed comparative analysis on 1,836 patients (mean age, 67 years; 66% male). In a median follow-up of 3.6 years, crude death rates (per 100 person-years) were 5.2, 10.6, and 13.0 in patients with normal aortic valves, aortic sclerosis, and mild-to-moderate AS, respectively. Compared with normal aortic valves, both aortic sclerosis and mild-to-moderate AS were associated with all-cause and cardiovascular death: adjusted hazard ratios (95% confidence intervals) were 1.36 (1.13–1.65) and 1.36 (1.02–1.80) for all-cause death; and 1.52 (1.06–2.17) and 1.74 (1.04–2.92) for cardiovascular death, respectively. Conclusions: Aortic sclerosis and mild-to-moderate AS were independent risk factors for all-cause and cardiovascular death in patients undergoing hemodialysis.

    DOI: 10.1016/j.atherosclerosis.2021.06.910

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  11. Validity of "One-size-fits-all" Approaches for the National Health Screening and Education Program: A Large-scale Cohort Study of Corporate Insurance Beneficiaries.

    Kikuchi K, Imaizumi T, Ando M, Kato S, Kondo T, Honda H, Yoshida Y, Maruyama S

    Internal medicine (Tokyo, Japan)   Vol. 60 ( 11 ) page: 1681 - 1689   2021.6

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    Publisher:一般社団法人 日本内科学会  

    <p><b>Objective </b>Metabolic syndrome represents a unified condition of atherosclerotic diseases caused by abdominal obesity. The aims of this study were to examine the applicability of the prevalent fixed cut-off values of the abdominal circumference (AC) and body mass index (BMI) to age and gender groups and to identify suitable lifestyle modification factors. </p><p><b>Methods </b>We defined an outcome as having ≥ 2 risk components that are necessary to diagnose metabolic syndrome and examined the cross-sectional association of the AC and BMI with the outcome. We also assessed the effects of time-updated lifestyle information on metabolic traits using longitudinal data. </p><p><b>Patients </b> We enrolled 22,953 beneficiaries of a corporate health insurance scheme who underwent annual health examinations between January 2004 and December 2014. </p><p><b>Results </b>The AC [per 5-cm increase, odds ratio (OR) 1.17, 95% confidence interval (CI) 1.12-1.24] and BMI (OR 1.10, 95% CI 1.07-1.13) were significantly associated with the outcome, adjusted for age, gender, current smoking status, drinking habits, and other lifestyle information. The association between the outcome and AC was modified by gender (p for interaction = 0.033), and the association between the outcome and BMI was modified by age group (p for interaction = 0.049). In the longitudinal analysis, current smoking, drinking habits, and unhealthy eating habits were associated with an increased AC and BMI, whereas regular physical activity was associated with a decreased AC and BMI. </p><p><b>Conclusion </b>We showed that the association between the AC or BMI and metabolic syndrome was modified by gender or age group. Further studies will be needed to customize the national health screening and education programs. </p>

    DOI: 10.2169/internalmedicine.5515-20

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  12. High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus

    Itano Yuya, Sobajima Hiroshi, Ohashi Norimi, Shibata Taiga, Fujiya Atsushi, Nagata Takanobu, Ando Masahiko, Imaizumi Takahiro, Kubo Yoko, Ozeki Takaya, Katsuno Takayuki, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

    JOURNAL OF DIABETES INVESTIGATION   Vol. 12 ( 6 ) page: 998 - 1006   2021.6

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    Publisher:Journal of Diabetes Investigation  

    DOI: 10.1111/jdi.13428

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  13. Postoperative computed tomography assessment of anteromedial cortex reduction is a predictor for reoperation after intramedullary nail fixation for pertrochanteric fractures.

    Yamamoto N, Imaizumi T, Noda T, Inoue T, Kawasaki K, Ozaki T

    European journal of trauma and emergency surgery : official publication of the European Trauma Society     2021.5

  14. Comparison between the effects of normal saline with and without heparin for the prevention and management of arterial catheter occlusion: a triple-blinded randomized trial

    Tamura Takahiro, Kobayashi Eri, Kawaguchi Mariko, Matsuoka Yuki, Fujii Akiko, Ando Masahiko, Kubo Yoko, Imaizumi Takahiro, Miyagawa Yasuhiro, Inagaki Takayuki, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA     2021.5

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    Publisher:Journal of Anesthesia  

    DOI: 10.1007/s00540-021-02949-1

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  15. Predictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome

    Yamato Genki, Deguchi Takao, Terui Kiminori, Toki Tsutomu, Watanabe Tomoyuki, Imaizumi Takahiro, Hama Asahito, Iwamoto Shotaro, Hasegawa Daisuke, Ueda Takahiro, Yokosuka Tomoko, Tanaka Shiro, Yanagisawa Ryu, Koh Katsuyoshi, Saito Akiko M., Horibe Keizo, Hayashi Yasuhide, Adachi Souichi, Mizutani Shuki, Taga Takashi, Ito Etsuro, Watanabe Kenichiro, Muramatsu Hideki

    LEUKEMIA   Vol. 35 ( 5 ) page: 1480 - 1484   2021.5

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  16. Glucocorticoid treatment is associated with ICU-acquired hypernatremia: a nested case-control study

    Imaizumi Takahiro, Nakatochi Masahiro, Fujita Yoshiro, Yamamoto Rie, Watanabe Kennshi, Maekawa Michitaka, Yamawaka Taishi, Katsuno Takayuki, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 2 ) page: 131 - 139   2021.2

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    Publisher:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-020-01967-9

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  17. Cardiovascular disease history and beta-blocker prescription patterns among Japanese and American patients with CKD: a cross-sectional study of the CRIC and CKD-JAC studies

    Imaizumi Takahiro, Hamano Takayuki, Fujii Naohiko, Huang Jing, Xie Dawei, Ricardo Ana C., He Jiang, Soliman Elsayed Z., Kusek John W., Nessel Lisa, Yang Wei, Maruyama Shoichi, Fukagawa Masafumi, Feldman Harold I.

    HYPERTENSION RESEARCH   Vol. 44 ( 6 ) page: 700 - 710   2021.1

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    Publisher:Hypertension Research  

    DOI: 10.1038/s41440-020-00608-8

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  18. The ISN/RPS 2016 classification predicts renal prognosis in patients with first-onset class III/IV lupus nephritis

    Hachiya Asaka, Karasawa Munetoshi, Imaizumi Takahiro, Kato Noritoshi, Katsuno Takayuki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Maruyama Shoichi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1525   2021.1

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  19. Prompt prediction of fibrinogen concentration during cardiopulmonary bypass: a pilot study

    Tamura Takahiro, Imaizumi Takahiro, Kubo Yoko, Waters Jonathan H., Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 623 - 630   2020.11

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    Publisher:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.82.4.623

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  20. URINARY CD11B AND CD163 REFLECT GLOMERULAR LEUKOCYTE ACCUMULATIONS IN ANCA-ASSOCIATED GLOMERULONEPHRITIS

    Tsuboi Naotake, Yokoe Yuki, Kitagawa Akimitsu, Karasawa Munetoshi, Imaizumi Takahiro, Ozeki Takaya, Takayuki Katsuno, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 35 - 36   2020.10

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  21. Additional prognostic value of toe-brachial index beyond ankle-brachial index in hemodialysis patients

    Hishida Manabu, Imaizumi Takahiro, Menez Steven, Okazaki Masaki, Akiyama Shin'ichi, Kasuga Hirotake, Ishigami Junichi, Maruyama Shoichi, Matsushita Kunihiro

    BMC NEPHROLOGY   Vol. 21 ( 1 ) page: 353   2020.8

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  22. Impact of old age on the association between in-center extended-hours hemodialysis and mortality in patients on incident hemodialysis

    Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Hishida Manabu, Kurasawa Shimon, Kubo Yoko, Kato Sawako, Yasuda Yoshinari, Katsuno Takayuki, Kaneda Fumika, Maruyama Shoichi

    PLOS ONE   Vol. 15 ( 7 ) page: e0235900   2020.7

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  23. Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

    Yokoe Y, Tsuboi N, Imaizumi T, Kitagawa A, Karasawa M, Ozeki T, Endo N, Sawa Y, Kato S, Katsuno T, Maruyama S, Yamagata K, Usui J, Nagata M, Sada KE, Sugiyama H, Amano K, Arimura Y, Atsumi T, Yuzawa Y, Dobashi H, Takasaki Y, Harigai M, Hasegawa H, Makino H, Matsuo S

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     2020.7

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  24. Survival Benefit of Maintained or Increased Body Mass Index in Patients Undergoing Extended-Hours Hemodialysis Without Dietary Restrictions

    Hishida Manabu, Imaizumi Takahiro, Nishiyama Toshiro, Okazaki Masaki, Kaihan Ahmad Baseer, Kato Sawako, Kubo Yoko, Ando Masahiko, Kaneda Hiroshi, Maruyama Shoichi

    JOURNAL OF RENAL NUTRITION   Vol. 30 ( 2 ) page: 154 - 162   2020.3

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    Publisher:Journal of Renal Nutrition  

    DOI: 10.1053/j.jrn.2019.06.002

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  25. Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus

    Kato Sawako, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Imaizumi Takahiro, Yamamoto Naoki, Maruyama Shoichi

    INTERNAL MEDICINE   Vol. 59 ( 1 ) page: 45 - 53   2020

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    Publisher:Internal Medicine  

    <p><b>Objective </b>Exercise therapy is used for glycemic control in type 2 diabetes mellitus (T2DM). We evaluated the effects of intensive health guidance using the Internet of things (IoT) among Japanese company workers with early T2DM. </p><p><b>Methods </b>Fifty-three men (mean age: 54 years) with glycated hemoglobin (HbA1c) levels of >6.5% were enrolled in a 6-month exercise therapy program between August 2016 and January 2017. They used activity meters, scales, and sphygmomanometers connected to the Internet by Bluetooth. These devices automatically and continuously recorded daily information, and the participants simultaneously received health guidance from a public health nurse twice a month. </p><p><b>Results </b>The number of daily steps significantly increased, whereas the amount of physical activity increased but was not significant. The mean decrease (±SD) in HbA1c levels after 3 and 6 months was estimated to be -0.40% (±0.45, p<0.0001) and -0.19% (±0.55, p=0.033), respectively, by a linear mixed model that included baseline HbA1c levels and age as covariates. The program failed to improve the body mass index and blood pressure of the participants. The percentage of active stage (action and maintenance stage) in stage of health behavior significantly increased from 48% to 68% (p=0.011). </p><p><b>Conclusion </b>Intensive lifestyle intervention using a wearable monitoring system and remote health guidance improved diabetic control in middle-aged company workers. </p>

    DOI: 10.2169/internalmedicine.3150-19

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  26. Influence of psychiatric or social backgrounds on clinical decision making: a randomized, controlled multi-centre study

    Yamauchi Yosuke, Shiga Takashi, Shikino Kiyoshi, Uechi Takahiro, Koyama Yasuaki, Shimozawa Nobuhiko, Hiraoka Eiji, Funakoshi Hiraku, Mizobe Michiko, Imaizumi Takahiro, Ikusaka Masatomi

    BMC MEDICAL EDUCATION   Vol. 19 ( 1 ) page: 461   2019.12

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    Publisher:BMC Medical Education  

    DOI: 10.1186/s12909-019-1897-z

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  27. Circulating levels of CD34(+) cells predict longterm cardiovascular outcomes in patients on maintenance hemodialysis

    Kaihan Ahmad Baseer, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Kaihan Ahmad Naseer, Katsuno Takayuki, Taguchi Akihiko, Yasuda Yoshinari, Tsuboi Naotake, Kosugi Tomoki, Maruyama Shoichi

    PLOS ONE   Vol. 14 ( 10 ) page: e0223390   2019.10

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  28. External validation of the quick Sequential Organ Failure Assessment score for mortality and bacteraemia risk evaluation in Japanese patients undergoing haemodialysis: a retrospective multicentre cohort study

    Nishiwaki Hiroki, Sasaki Sho, Hasegawa Takeshi, Sasai Fumihiko, Kawarazaki Hiroo, Minatoguchi Shun, Uchida Daisuke, Koitabashi Kenichiro, Ozeki Takaya, Koiwa Fumihiko, Furusho Masahide, Nomura Atsushi, Shimizu Hideaki, Ryuge Akihiro, Imaizumi Takahiro, Murasawa Masaru, Raita Yoshihiko, Saka Yosuke, Yazawa Masahiko, Terashita Maho, Suzuki Yasunori, Fujita Yoshiro, Murakami Minoru, Maruta Yuichi, Oikawa Megumi, Saito Hisako, Mizukami Aya, Omiya Shinya, Shibagaki Yugo

    BMJ OPEN   Vol. 9 ( 7 )   2019.8

  29. Clinical impact of endocapillary proliferation with modified cutoff points in IgA nephropathy patients

    Kaihan Ahmad Baseer, Yasuda Yoshinari, Imaizumi Takahiro, Inagaki Koji, Ozeki Takaya, Hishida Manabu, Katsuno Takayuki, Tsuboi Naotake, Maruyama Shoichi

    PLOS ONE   Vol. 14 ( 3 ) page: e0214414   2019.3

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  30. Spontaneous remission of giant cell arteritis: possible association with a preceding acute respiratory infection and seropositivity to Chlamydia pneumoniae antibodies

    Maekawa Michitaka, Iwadate Tomonobu, Watanabe Kenshi, Yamamoto Rie, Imaizumi Takahiro, Yamakawa Taishi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page: 151 - 158   2019.2

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    Publisher:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.81.1.151

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  31. Low serum albumin as a risk factor for infection-related in-hospital death among hemodialysis patients hospitalized on suspicion of infectious disease: A Japanese multicenter retrospective cohort study

    Minatoguchi S.

    Renal Replacement Therapy   Vol. 4 ( 1 )   2018.8

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    Publisher:Renal Replacement Therapy  

    DOI: 10.1186/s41100-018-0173-8

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  32. Unfavorable effects of history of volume overload and late referral to a nephrologist on mortality in patients initiating dialysis: a multicenter prospective cohort study in Japan

    Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Kada Akiko, Yaomura Takaaki, Tsuboi Naotake, Maruyama Shoichi

    BMC NEPHROLOGY   Vol. 19 ( 1 ) page: 65   2018.3

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  33. Effect of dietary energy and polymorphisms in &ITBRAP&IT and &ITGHRL&IT on obesity and metabolic traits

    Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

    OBESITY RESEARCH & CLINICAL PRACTICE   Vol. 12 ( 1 ) page: 39 - 48   2018

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    Publisher:Obesity Research and Clinical Practice  

    DOI: 10.1016/j.orcp.2016.05.004

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  34. Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease

    Kikuchi Ryosuke, Yasuda Yoshinari, Nakatochi Masahiro, Shibata Yohei, Hara Toshiaki, Suzuki Atsuo, Imaizumi Takahiro, Suzuki Susumu, Ishii Hideki, Takeshita Kyosuke, Matsushita Tadashi, Maruyama Shoichi, Murohara Toyoaki

    CLINICA CHIMICA ACTA   Vol. 475   page: 102 - 108   2017.12

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    Publisher:Clinica Chimica Acta  

    DOI: 10.1016/j.cca.2017.10.014

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  35. The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients

    Kaihan Ahmad Baseer, Yasuda Yoshinari, Katsuno Takayuki, Kato Sawako, Imaizumi Takahiro, Ozeki Takaya, Hishida Manabu, Nagata Takanobu, Ando Masahiko, Tsuboi Naotake, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 6 ) page: 986 - 994   2017.12

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    Publisher:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-017-1393-x

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  36. Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission

    Inagaki Koji, Yasuda Yoshinari, Ando Masahiko, Kaihan Ahmad Baseer, Hachiya Asaka, Ozeki Takaya, Hishida Manabu, Imaizumi Takahiro, Katsuno Takayuki, Kato Sawako, Tsuboi Naotake, Maruyama Shoichi

    PLOS ONE   Vol. 12 ( 11 ) page: e0187607   2017.11

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  37. Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers

    Kubo Yoko, Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kikuchi Kyoko, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

    PLOS ONE   Vol. 12 ( 10 ) page: e0185476   2017.10

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  38. The association between intensive care unit-acquired hypernatraemia and mortality in critically ill patients with cerebrovascular diseases: a single-centre cohort study in Japan

    Imaizumi Takahiro, Nakatochi Masahiro, Fujita Yoshiro, Nomura Rie, Watanabe Kenshi, Maekawa Michitaka, Yamakawa Taishi, Katsuno Takayuki, Maruyannal Shoichi

    BMJ OPEN   Vol. 7 ( 8 ) page: e016248   2017.8

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  39. Association Between Staphylococcus aureus Bacteremia and Hospital Mortality in Hemodialysis Patients With Bloodstream Infection: A Multicenter Cohort From Japanese Tertiary Care Centers

    Imaizumi Takahiro, Hasegawa Takeshi, Nomura Atsushi, Sasaki Sho, Nishiwaki Hiroki, Ozeki Takaya, Shimizu Hideaki, Minatoguchi Shun, Yamakawa Taishi, Yazawa Masahiko, Uchida Daisuke, Kawarazaki Hiroo, Miyamoto Masahito, Suzuki Tomo, Koitabashi Ken'ichiro, Furusho Masahide, Fujita Yoshiro

    THERAPEUTIC APHERESIS AND DIALYSIS   Vol. 21 ( 4 ) page: 354 - 360   2017.8

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    Publisher:Therapeutic Apheresis and Dialysis  

    DOI: 10.1111/1744-9987.12534

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  40. Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers

    Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Maruyama Shoichi, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Matsuo Seiichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 3 ) page: 457 - 464   2017.6

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    Publisher:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-016-1315-3

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  41. Development and Validation of a Clinical Prediction Rule for Bacteremia among Maintenance Hemodialysis Patients in Outpatient Settings

    Sasaki Sho, Hasegawa Takeshi, Kawarazaki Hiroo, Nomura Atsushi, Uchida Daisuke, Imaizumi Takahiro, Furusho Masahide, Nishiwaki Hiroki, Fukuma Shingo, Shibagaki Yugo, Fukuhara Shunichi

    PLOS ONE   Vol. 12 ( 1 ) page: e0169975   2017.1

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  42. Acute Renal Failure with Severe Loin Pain and Patchy Renal Vasoconstriction in a Patient without Hypouricemia, Provoked by Epileptic Seizure

    Maekawa Michitaka, Imaizumi Takahiro, Yamakawa Taishi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 56 ( 15 ) page: 2001 - 2005   2017

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    Publisher:Internal Medicine  

    <p>A 26-year-old Japanese man without hypouricemia and with 3 previous episodes of seizures concurrent with acute kidney injury (AKI) was admitted due to an epileptic seizure, lower back pain and AKI. His creatinine kinase levels were slightly elevated. Patchy renal ischemia on contrast-enhanced computed tomography and persistent residual contrast medium was observed, consistent with acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE). Diffusion-weighted imaging (DWI) demonstrated signal changes in the corresponding area. ALPE should be considered a cause of AKI following seizures. We recommend DWI as an alternative diagnostic modality. </p>

    DOI: 10.2169/internalmedicine.56.8328

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▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. 慢性腎臓病患者における生体内細菌叢をターゲットにした新規抗老化療法の開発

    Grant number:22K08328  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    加藤 佐和子, 丸山 彰一, 今泉 貴広, 小杉 智規

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    Authorship:Coinvestigator(s) 

    慢性腎臓病(CKD)患者の表現系は老化に見られる諸変化に酷似している。通常の維持血液透析患者(従来透析)と長時間透析患者、保存期腎不全患者は、尿毒症にさらされている強度や条件が異なる。尿毒症存在下において、どのような外的・内的環境負荷(Allostatic load)が免疫学的変調と慢性炎症をきたし、Microbiomeの変調をきたすのか、老化の指標となる遺伝子保護の不調(テロメア消耗)に関与しているか解析し、実際の心疾患、感染症、死亡率と比較することにより、腸内細菌叢の改善をターゲットとしたCKD患者の新規治療戦略の構築を目指すものである。

  2. Establishment of quality control process in clinical trials by utilizing hospital information system

    Grant number:22K10360  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  3. 部位別腎病理スコアと機能学的メタボローム解析を融合した新規腎病理評価系の確立

    Grant number:22K16238  2022.4 - 2024.3

    科学研究費助成事業  若手研究

    今泉 貴広

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    本研究の概要は、従来の疾患分類に重きを置いた腎生検の分類に対して、構造的特徴に着目した「部位別腎病理スコア」の考え方と機能的特徴に着目したメタボローム解析を融合させることで、全く新しい評価系を確立し、幅広い腎疾患の予後推定を行う研究である。名古屋大学腎臓内科及びその関連病院20以上の関連施設との間で構築した腎生検レジストリー事業で収集した検体を用いて研究を実施する。
    構造的特徴として、診断分類とは独立して腎病理標本中の糸球体、尿細管・間質、血管といった部位別に病変の特徴を定量的に評価する「部位別腎病理スコア」を開発する。次にメタボローム解析結果と組み合わせて予後予測モデルの構築を行う。

  4. MIA症候群を克服する透析法・長時間透析療法の予後改善効果の解明

    Grant number:20K17277  2020.4 - 2022.3

    若手研究

    今泉 貴広

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    1回6~8時間の透析時間と自由食を特色とした「長時間透析療法」は、従来透析と比して高いQOLと良好な予後を示す。
    低栄養の改善と動脈硬化進展抑制が寄与するという仮説に基づき、そのメカニズムを明らかにすることが本研究の目的である。
    そのために、CKD-mineral bone disorder関連マーカーの関与と、既知・未知の尿毒素の網羅的検索をメタボローム解析にて実施する。さらに細胞実験を実施して上記仮説を検証する。