研究者詳細 - 田中　章仁

論文 - 田中　章仁

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Prediction model for cardiovascular events or all-cause mortality in incident dialysis patients 査読有り

Inaguma Daijo, Morii Daichi, Kabata Daijiro, Yoshida Hiroyuki, Tanaka Akihito, Koshi-Ito Eri, Takahashi Kazuo, Hayashi Hiroki, Koide Shigehisa, Tsuboi Naotake, Hasegawa Midori, Shintani Ayumi, Yuzawa Yukio

PLOS ONE 14 巻 ( 8 ) 2019年8月

Efficacy of Long‐Term Treatment With Tolvaptan to Prolong the Time Until Dialysis Initiation in Patients With Chronic Kidney Disease and Heart Failure 査読有り

Tanaka A, Hiramatsu E, Watanabe Y, Ito C, Shinjo H, Otsuka Y, Takeda A.

Therapeutic Apheresis and Dialysis 2019年8月

Successful treatment of peritoneal dialysis-related peritonitis caused by Dermacoccus nishinomiyaensis 査読有り

Tanaka A, Watanabe Y, Ito C, et al.

CEN Case Reports 2019年8月

Hepatitis B Virus Infection Among Patients With Chronic Kidney Disease Who Attended an Educational Program in Japan 査読有り

Tanaka A, et al.

Therapeutic Apheresis and Dialysis 6 巻頁： 588 - 593 2018年12月

Ratio of blood urea nitrogen to serum creatinine at initiation of dialysis is associated with mortality: A multicenter prospective cohort study 査読有り

Inaguma D., Koide S., Ito E., Takahashi K., Hayashi H., Hasegawa M., Yuzawa Y., Tanaka A., Murata M., Shinjo H., Otsuka Y., Takeda A., Tamai H., Naruse T., Kurata K., Oishi H., Aoyama I., Ogawa H., Kushimoto H., Shimizu H., Yamamoto J., Kurata H., Yamakawa T., Yaomura T., Kasuga H., Ichida S., Maruyama S., Matsuo S., Kato N.

Clinical and Experimental Nephrology 22 巻 ( 2 ) 頁： 353 - 364 2018年4月

出版者・発行元：Clinical and Experimental Nephrology

Background Some studies have shown that the estimated glomerular filtration rate (eGFR) at the time of initiating dialysis was associated with mortality. However, the relationship between ratio of blood urea nitrogen to serum creatinine (BUN/Cr) and mortality is unknown. Methods The study was a multicenter, prospective cohort analysis including 1520 patients. Patients were classified into four quartiles based on the BUN/Cr ratio at the dialysis initiation, with Q1 having the lowest ratio and Q4 the highest. All-cause mortality after initiating dialysis was compared using the log-rank test. All-cause mortality of Q1, Q2, and Q3 was compared with that of Q4 using multivariate Cox proportional hazard regression analysis. Moreover, we compared the renal parameters including BUN/Cr ratio, eGFR, and creatinine clearance for sensitivity and specificity using receiver operative characteristic (ROC) curve. Results Significant differences were observed in all-cause mortality among the four groups (p<0.001). Multivariate analysis revealed that all-cause mortality was significantly higher in Q4 than in Q1 [hazard ratio (HR) = 1.82, 95% confidence interval (CI) 1.24–2.67, p = 0.002]. The increase in BUN/Cr ratio was positively associated with mortality (HR 1.04, 95% CI 1.02–1.06, p = 0.002). The sensitivity and specificity of BUN/Cr ratio for 180, 365, 730, and 1095 days mortality ranged between 0.60–0.72 and 0.59–0.71, respectively. The area under the curve of BUN/Cr for all-cause mortality was the highest among the renal parameters. Conclusion The BUN/Cr ratio at the time of initiation of dialysis was associated with all-cause mortality.

DOI： 10.1007/s10157-017-1458-x

Scopus

Relationship Between Mortality and Cancer-Bearing Status in Patients With Chronic Kidney Disease Who Attended an Educational Program. 査読有り

Tanaka A, Inaguma D, Watanabe Y, Murata M, Shinjo H, Koike K, Otsuka Y, Takeda A

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 22 巻 ( 1 ) 頁： 49 - 57 2018年2月

記述言語：英語出版者・発行元：Therapeutic Apheresis and Dialysis

Patients with malignancy have a poorer prognosis than others do, which must be taken into consideration when treating them for chronic kidney disease (CKD). However, there are few studies investigating their prognosis. This was an observational study of 515 (394 men and 121 women) stable non-dialysis patients with CKD who attended a CKD educational program. Mean age was 68.8 ± 13.0 years. Median follow-up was 968.5 days. Mean creatinine was 3.4 ± 1.6 mg/dL. Of these, 63 had malignancy and 452 did not; 20.6% of the former and 11.9% of the latter group died by the end of the study period (P = 0.0548). Malignancy was not associated with all-cause mortality (HR: 1.3475, 95% CI: 0.7202–2.5214, P = 0.3507) but with malignancy-associated mortality (HR: 3.9477, 95% CI: 1.6348–9.5331, P = 0.0023). Renal replacement therapy was not associated with mortality. Since malignancy greatly affects the prognosis, it must be taken into consideration when treating these patients.

DOI： 10.1111/1744-9987.12598

Scopus

PubMed

Relationship between the Normalized Protein Catabolic Rate and Mortality or Renal Prognosis in Elderly Patients with Chronic Kidney Disease:A Retrospective Analysis 査読有り

Akihito Tanaka, et al.

Therapeutic Research 39 巻 ( 8 ) 頁： 699 - 708 2018年

Evaluation of the Relationship between the Serum Alkaline Phosphatase Level at Dialysis Initiation and All-Cause Mortality: A Multicenter, Prospective Study 査読有り

Akiko Owaki, Daijo Inaguma, Akihito Tanaka, et al.

Nephron Extra 7 巻 ( 3 ) 頁： 78 - 88 2017年11月

Relationship Between Mortality and Cancer-Bearing Status at Time of Dialysis Initiation. 査読有り

Tanaka A, Inaguma D, Shinjo H, Murata M, Takeda A

記述言語：英語出版者・発行元：Therapeutic Apheresis and Dialysis

Patients with malignancy are reported to have poorer prognosis than those without malignancy. When patients with malignancy develop end-stage kidney disease, clinicians must determine treatment with consideration of prognosis. Furthermore, malignancy is sometimes found at time of dialysis initiation. However, prognosis of patients with malignancy at time of dialysis initiation has not been investigated. A total of 1524 patients with chronic kidney disease who initiated dialysis at 17 centers participating in the Aichi Cohort Study of Prognosis in Patients Newly Initiated into Dialysis were included. Patients initiated dialysis between October 2011 and September 2013. Mortality rates were compared between patients with and without malignancy. Types of malignancy and respective prognoses also were assessed. The study included 1030 men and 492 women with a mean age of 67.5 ± 13.1 years. Of these, 92 had malignancy and 1430 did not; 45.7% of the former group and 16.0% of the latter group died by March 2015 (P < 0.01). Even after adjusting for various factors, presence of malignancy remained an independent risk factor for mortality (P < 0.01). Patients with performance status (PS) of 0 had significantly lower mortality (P < 0.01). Patients with malignancy at time of dialysis initiation had poor prognosis. Therefore, presence of malignancy should be taken into consideration when patients initiate dialysis. In patients with malignancy, better PS was associated with better prognosis.

DOI： 10.1111/1744-9987.12525

Scopus

PubMed

Factors associated with severity of sleep apnoea syndrome in patients with chronic kidney disease 査読有り

Tanaka A, et al.

Acta Cardiologica 72 巻 ( 4 ) 頁： 440 - 445 2017年8月

Ferrokinetics is associated with the left ventricular mass index in patients with chronic kidney disease 査読有り

Tanaka A, et al.

Acta Cardiologica 72 巻 ( 4 ) 頁： 460 - 466 2017年8月

Relationship between mortality and Geriatric Nutritional Risk Index (GNRI) at the time of dialysis initiation: A prospective multicenter cohort study 査読有り

Tanaka A., Inaguma D., Shinjo H., Murata M., Takeda A.

Renal Replacement Therapy 3 巻 ( 1 ) 2017年7月

担当区分：筆頭著者記述言語：日本語出版者・発行元：Renal Replacement Therapy

Background: The Geriatric Nutritional Risk Index (GNRI) is a nutritional screening method primarily developed for elderly people; it is also reported to be useful for predicting mortality in patients on maintenance dialysis. However, it is unclear whether it is useful at the time of dialysis initiation, which is accompanied by large weight fluctuations and unstable nutritional status. Methods: The study included 1524 patients with chronic kidney disease who commenced dialysis therapy at 17 centers. Patients commenced dialysis between October 2011 and September 2013 and were followed up until March 2015. Results: We analyzed 1489 patients whose GNRI could be calculated and whose prognosis was clear. The mean GNRI was 87.60 (median 87.86). We divided patients based on the median value into a high (H) and low (L) group. The H group included 728 patients (mean GNRI 95.2 ± 4.9, mean age 65.8 ± 13.2 years, 69.3% men), and the L group included 761 patients (mean GNRI 80.3 ± 6.1, mean age 69.1 ± 12.8 years, 66.0% men). Mortality was significantly higher in the L group (L, 22.2% vs. H, 12.6%, P < 0.001). The rates of infection-associated death in the L group was significantly higher (L, 5.5% vs. H, 1.9%, P < 0.001), although no significant difference was observed regarding cardiovascular disease-associated death (L, 7.6% vs. H, 5.2%, P = 0.059) and malignancy-associated death (L, 3.0% vs. H, 3.0%, P = 1.000). Multivariate analysis showed an association between GNRI and all-cause mortality (HR 0.9852, 95%CI 0.9707-0.9999, P = 0.049) and infection-associated death (HR 0.9484, 95%CI 0.9191-0.9786, P < 0.001). Conclusions: GNRI is useful for predicting mortality even at the time of dialysis initiation. Among the causes of death, GNRI was strongly associated with infection-associated death.

DOI： 10.1186/s41100-017-0108-9

Scopus

Physical function at the time of dialysis initiation is associated with subsequent mortality 査読有り

Daijo Inaguma, Akihito Tanaka, Hibiki Shinjo

Clinical and Experimental Nephrology 21 巻 ( 3 ) 頁： 425 - 435 2017年7月

Relationship between mortality and speed of eGFR decline in the 3 months prior to dialysis initiation. 査読有り

Inaguma D, Murata M, Tanaka A, Shinjo H

Clinical and experimental nephrology 21 巻 ( 1 ) 頁： 159 - 168 2017年2月

Two Patients with Familial Hypercholesterolemia Who Were Successfully Weaned from Low-density Lipoprotein Apheresis after Treatment with Evolocumab. 査読有り

Tanaka A, Inaguma D, Watanabe Y, Ito E, Kamegai N, Shimogushi H, Shinjo H, Koike K, Otsuka Y, Takeda A

Internal medicine (Tokyo, Japan) 56 巻 ( 12 ) 頁： 1531 - 1535 2017年

Effect of continuous hemodiafiltration using an AN69ST membrane in patients with sepsis 査読有り

Tanaka A, et al.

Renal Replacement Therapy 3 巻頁： 12 2017年

Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients 査読有り

Daijo Inaguma, Hibiki Shinjo, Akihito Tanaka, et al.

Clinical Nephrology 86 巻 ( 11 ) 頁： 229 - 235 2016年11月

Superior Vena Cava Syndrome-like Phenomenon on Vascular Access 査読有り

Tanaka A. et al.

Heart Views 17 巻 ( 4 ) 頁： 164 - 165 2016年10月

Predialysis Vitamin D Receptor Activator Treatment and Cardiovascular Events after Dialysis Initiation: A Multicenter Observational Study 査読有り

Daijo Inaguma, Akihito Tanaka, et al.

Nephron 133 巻 ( 1 ) 頁： 35 - 43 2016年4月

Presence of Atrial Fibrillation at the Time of Dialysis Initiation Is Associated with Mortality and Cardiovascular Events 査読有り

Tanaka A, et al.

Nephron 132 巻 ( 2 ) 頁： 86 - 92 2016年2月

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