Updated on 2024/03/25

写真a

 
SATO Yuka
 
Organization
Nagoya University Hospital Nephrology Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. Doctor of Philosophy(Medical Science) ( 2015.1   Nagoya University ) 

Research Areas 1

  1. Life Science / Nephrology

Research History 4

  1. Nagoya University   Assistant professor of hospital

    2020.4

  2. Nagoya University   Designated assistant professor

    2019.4 - 2020.3

  3. University Colorado   Department of Medicine, Division of Renal and Hypertension   Researcher

    2016.9 - 2018.12

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    Country:United States

  4. Japan Society for Promotion of Science   Researcher

    2016.9 - 2018.8

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    Country:United States

Education 2

  1. Nagoya University

    2008.4 - 2012.3

  2. Nagoya University

    1997.4 - 2003.3

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    Country: Japan

Professional Memberships 3

  1. 日本腎臓学会

  2. 日本透析医学会

  3. 日本内科学会

Awards 1

  1. 最優秀研究賞

    2012.7   腎疾患と高血圧研究会   ミッドカインが内皮由来血管拡張因子を介した血圧制御に関与する

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    Award type:Award from publisher, newspaper, foundation, etc. 

 

Papers 30

  1. Climate Change and Nephrology Invited Reviewed International coauthorship

    Nephrol Dial Transplant.   Vol. 38 ( 1 ) page: 41 - 48   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria. Reviewed

    Watanabe T, Maeda K, Kato N, Seko H, Sugimura M, Sato Y, Ryuge A, Kato S, Kadomatsu K, Maruyama S, Kosugi

    Nephrology   Vol. 28 ( 11 ) page: 629 - 638   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/nep.14227.

  3. Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis Reviewed

    Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K

    JCI insight   Vol. 6 ( 20 ) page: e142464.   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/jci.insight.142464.

  4. Safety and utility of the alpha-replacer for treatment of intraluminal obstruction of peritoneal catheters by fibrin clots.

    Asai A, Kinashi H, Suzuki Y, Kojima H, Sato Y, Matsuoka N, Asai N, Kuroyanagi Y, Yamaguchi M, Nobata H, Katsuno T, Ishimoto T, Mizuno M, Ito Y.

    Clin Exp Nephrol.     2021

  5. Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed

    uzuki Y, Mizuno M, Sakata F, Kojima H, Sato Y, Kishimoto M, Suzuki N, Kinashi H, Saito S, Katsuno T, Kosugi T, Maruyama S, Murata M, Kiyoi H, Ito Y

    Intern Med.   Vol. 59 ( 5 ) page: 683 - 687   2020

  6. The increase of core temperature affected the progression of kidney injury by repeated heat stress exposure

    Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ.

    Am J Physiol Renal Physiol.     2019

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    Authorship:Lead author  

  7. CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling.

    Yoshioka T, Kosugi T, Masuda T, Watanabe T, Ryuge A, Nagaya H, Kayaho M, Sato Y, Katsuno T, Kato N, Ishimoto T, Yuzawa Y, Maruyama S, Kadomatsu K.

    Am J Pathol.     2019

  8. The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD.

    Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ.

    Nat Rev Nephrol.     2019

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    Authorship:Lead author  

  9. Obesity Causes Renal Mitochondrial Dysfunction and Energy Imbalance and Accelerates Chronic Kidney Disease in Mice.

    Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ.

    Am J Physiol Renal Physiol.     2019

  10. Experimental heat stress nephropathy and liver injury are improved by allopurinol

    Roncal-Jimenez CA, Sato Y, Milagres T, Andres Hernando A, García G, Bjornstad P, Dawson JB, Sorensen C, Newman L, Krisher L, Madero M, Glaser J, Gárcía-Trabanino R, Romero EJ, Song Z, Jensen T, Kuwabara M, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ.

    Am J Physiol Renal Physiol.     2018

  11. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.

    Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ.

    Hypertension.     2018

  12. Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study.

    Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ.

    Hypertension.     2017

  13. Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis

    Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K.

    Am J Pathol.     2017

  14. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice.

    Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ

    Am J Physiol Renal Physiol.     2017

  15. Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids.

    Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.

    J Am Soc Nephrol.     2015

  16. CD147/Basigin limits lupus nephritis and TH 17 cell differentiation by inhibiting the IL-6/STAT3 pathway

    Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, Kato N, Tsuboi N, Yuzawa Y, Matsuo S, Murakami M, Maruyama S, Kadomatsu K

    Arthritis Rheumatol     2015

  17. Midkine in nephrogenesis, hypertension and kidney diseases.

    Sato W, Sato Y.

    Br J Pharmacol.     2014

  18. Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis.

    Suzuki Y, Mizuno M, Kojima H, Sato Y, Kim H, Kinashi H, Katsuno T, Ishimoto T, Maruyama S, Ito Y.

    Internal Medicine     2021

  19. Climate Change and the Kidney

    Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA.

    Ann Nutr Metab.     2019

  20. The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

    Mori Y, Masuda T, Kosugi T, Yoshioka T, Hori M, Nagaya H, Maeda K, Sato Y, Kojima H, Kato N, Ishimoto T, Katsuno T, Yuzawa Y, Kadomatsu K, Maruyama S.

    Clin Exp Nephrol.     2018

  21. Different effects of global osteopontin and macrophage osteopontin in glomerular injury.

    Trostel J, Truong LD, Roncal-Jimenez C, Miyazaki M, Miyazaki-Anzai S, Kuwabara M, McMahan R, Andres-Hernando A, Sato Y, Jensen T, Lanaspa MA, Johnson RJ, Garcia GE.

    Am J Physiol Renal Physiol     2018

  22. Rehydration with fructose worsens dehydration-induced renal damage

    Milagres T, García-Arroyo FE, Lanaspa MA, Garcia G, Ishimoto T, Andres-Hernando A, Kuwabara M, Jensen T, Sato Y, Glaser J, Sánchez-Lozada LG, Johnson RJ, Roncal-Jimenez C.

    BMC Nephrol.     2018

  23. Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver.

    Jensen T, Niwa K, Hisatome I, Kanbay M, Andres-Hernando A, Roncal-Jimenez CA, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ, Kuwabara M.

    Sci Rep     2018

  24. Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.

    Johnson RJ, Perez-Pozo SE, Lillo JL, Grases F, Schold JD, Kuwabara M, Sato Y, Hernando AA, Garcia G, Jensen T, Rivard C, Sanchez-Lozada LG, Roncal C, Lanaspa MA.

    BMC Nephrol.     2018

  25. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

    Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ.

    J Hepatol.     2018

  26. Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study.

    Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ.

    Obesity     2017

  27. Plasma CD147 reflects histological features in patients with lupus nephritis

    Maeda-Hori M, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson RJ, Matsuo S, Kadomatsu K, Maruyama S

    Lupus.     2014

  28. CD147/basigin reflects renal dysfunction in patients with acute kidney injury.

    Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

    Clin Exp Nephrol.     2014

  29. Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis.

    Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.

    Am J Pathol.     2013

  30. Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction.

    Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K.

    Am J Pathol.     2011

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MISC 2

  1. Reply to 'The case for evidence-based medicine for the association between hyperuricaemia and CKD' Invited Reviewed International coauthorship

    Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ.

    Nat Rev Nephrol.   Vol. 16 ( 7 ) page: 422 - 423   2020.7

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    Authorship:Lead author   Language:English  

    DOI: 10.1038/s41581-020-0289-2.

  2. 昇熱ストレスによる腎障害 Invited

    佐藤由香

    医学のあゆみ   Vol. 273 ( 7 ) page: 595 - 596   2020.5

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 腎所属リンパ節を標的とするAKI-to-CKD transitionの新規治療戦略の構築

    2023.4 - 2026.3

    日本学術振興会  基盤(C) 

  2. 高温環境によるCKD発症の病態解明と細胞老化制御を介した治療標的の探索

    Grant number:20K08607  2020.4 - 2023.3

    佐藤 由香

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    暑い環境での体温上昇が慢性腎臓病(CKD)を惹起進展させるという新しい病態が報告されている。日本でも夏の気温上昇に伴い、熱中症の発症率・死亡率が特に高齢者で増加しており、熱ストレスによる腎障害の病態解明は本邦でも望まれる。申請者らは、繰り返す高温暴露により腎障害に進展する動物モデルを作成した。同モデルで長寿遺伝子Sirtuin1(Sirt1)の低下を認めたことから、病態への老化の関与が疑われた。そこで本研究では、まずは個体老化に注目し加齢が熱ストレス誘導性腎障害のリスクであることを老化促進マウスを使い検討する。さらに細胞老化における熱ストレスの分子病態を解明し、新たな治療標的を探索する。

  3. Usefulness of Basigin as a novel therapeutic target for diabetic kidney and liver diseases

    Grant number:20K08632  2020.4 - 2023.3

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    Authorship:Coinvestigator(s) 

 

Teaching Experience (On-campus) 2

  1. 選択講義 よくわかる電解質酸塩基平衡 ナトリウム

    2022

  2. 糸球体疾患

    2022

 

Social Contribution 1

  1. 市民公開講座 腎臓病セミナー

    Role(s):Panelist

    朝日新聞  2023.3