Organization
Nagoya University Hospital Nephrology Assistant professor of hospital
Title
Assistant professor of hospital
SATO Yuka
Degree 1
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Doctor of Philosophy（Medical Science） （ 2015.1 Nagoya University ）
Research Areas 1
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Life Science / Nephrology
Research History 4
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Nagoya University Assistant professor of hospital
2020.4
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Nagoya University Designated assistant professor
2019.4 - 2020.3
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University Colorado Department of Medicine, Division of Renal and Hypertension Researcher
2016.9 - 2018.12
Country：United States
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Japan Society for Promotion of Science Researcher
2016.9 - 2018.8
Country：United States
Education 2
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Nagoya University
2008.4 - 2012.3
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Nagoya University
1997.4 - 2003.3
Country： Japan
Professional Memberships 3
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日本腎臓学会
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日本透析医学会
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日本内科学会
Awards 2
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JSN/ERA Symposium Award 2024 -Outstanding Abstract Award
2024.9 Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT Immune response mediated by kidney drainage lymph nodes in ischemic renal injury
Yuka Sato
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最優秀研究賞
2012.7 腎疾患と高血圧研究会 ミッドカインが内皮由来血管拡張因子を介した血圧制御に関与する
Papers 31
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Detecting and exploring kidney-derived extracellular vesicles in plasma. Reviewed
Clin Exp Nephrol. 2024.7
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Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria. Reviewed
Watanabe T, Maeda K, Kato N, Seko H, Sugimura M, Sato Y, Ryuge A, Kato S, Kadomatsu K, Maruyama S, Kosugi
Nephrology Vol. 28 ( 11 ) page： 629 - 638 2023.11
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Climate Change and Nephrology Reviewed International coauthorship
Sasai F, Roncal-Jimenez C, Rogers K, Sato Y, Brown JM, Glaser J, Garcia G, Sanchez-Lozada LG, Rodriguez-Iturbe B, Dawson JB, Sorensen C, Hernando AA, Gonzalez-Quiroz M, Lanaspa M, Newman L, Johnson RJ.
Nephrol Dial Transplant. Vol. 38 ( 1 ) page： 41 - 48 2023.1
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Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis Reviewed
Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K
JCI insight Vol. 6 ( 20 ) page： e142464. 2021.10
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Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis. Reviewed
Suzuki Y, Mizuno M, Kojima H, Sato Y, Kim H, Kinashi H, Katsuno T, Ishimoto T, Maruyama S, Ito Y.
Internal Medicine 2021
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Safety and utility of the alpha-replacer for treatment of intraluminal obstruction of peritoneal catheters by fibrin clots. Reviewed
Asai A, Kinashi H, Suzuki Y, Kojima H, Sato Y, Matsuoka N, Asai N, Kuroyanagi Y, Yamaguchi M, Nobata H, Katsuno T, Ishimoto T, Mizuno M, Ito Y.
Clin Exp Nephrol. 2021
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Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed
uzuki Y, Mizuno M, Sakata F, Kojima H, Sato Y, Kishimoto M, Suzuki N, Kinashi H, Saito S, Katsuno T, Kosugi T, Maruyama S, Murata M, Kiyoi H, Ito Y
Intern Med. Vol. 59 ( 5 ) page： 683 - 687 2020
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The increase of core temperature affected the progression of kidney injury by repeated heat stress exposure Reviewed
Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ.
Am J Physiol Renal Physiol. 2019
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Climate Change and the Kidney Reviewed
Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA.
Ann Nutr Metab. 2019
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CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling. Reviewed
Yoshioka T, Kosugi T, Masuda T, Watanabe T, Ryuge A, Nagaya H, Kayaho M, Sato Y, Katsuno T, Kato N, Ishimoto T, Yuzawa Y, Maruyama S, Kadomatsu K.
Am J Pathol. 2019
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The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD. Reviewed
Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ.
Nat Rev Nephrol. 2019
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Obesity Causes Renal Mitochondrial Dysfunction and Energy Imbalance and Accelerates Chronic Kidney Disease in Mice. Reviewed
Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ.
Am J Physiol Renal Physiol. 2019
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The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases Reviewed
Mori Y, Masuda T, Kosugi T, Yoshioka T, Hori M, Nagaya H, Maeda K, Sato Y, Kojima H, Kato N, Ishimoto T, Katsuno T, Yuzawa Y, Kadomatsu K, Maruyama S.
Clin Exp Nephrol. 2018
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Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Reviewed
Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ.
Hypertension. 2018
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Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. Reviewed
Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ.
J Hepatol. 2018
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Experimental heat stress nephropathy and liver injury are improved by allopurinol Reviewed
Roncal-Jimenez CA, Sato Y, Milagres T, Andres Hernando A, García G, Bjornstad P, Dawson JB, Sorensen C, Newman L, Krisher L, Madero M, Glaser J, Gárcía-Trabanino R, Romero EJ, Song Z, Jensen T, Kuwabara M, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ.
Am J Physiol Renal Physiol. 2018
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Different effects of global osteopontin and macrophage osteopontin in glomerular injury. Reviewed
Trostel J, Truong LD, Roncal-Jimenez C, Miyazaki M, Miyazaki-Anzai S, Kuwabara M, McMahan R, Andres-Hernando A, Sato Y, Jensen T, Lanaspa MA, Johnson RJ, Garcia GE.
Am J Physiol Renal Physiol 2018
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Rehydration with fructose worsens dehydration-induced renal damage Reviewed
Milagres T, García-Arroyo FE, Lanaspa MA, Garcia G, Ishimoto T, Andres-Hernando A, Kuwabara M, Jensen T, Sato Y, Glaser J, Sánchez-Lozada LG, Johnson RJ, Roncal-Jimenez C.
BMC Nephrol. 2018
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Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver. Reviewed
Jensen T, Niwa K, Hisatome I, Kanbay M, Andres-Hernando A, Roncal-Jimenez CA, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ, Kuwabara M.
Sci Rep 2018
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Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. Reviewed
Johnson RJ, Perez-Pozo SE, Lillo JL, Grases F, Schold JD, Kuwabara M, Sato Y, Hernando AA, Garcia G, Jensen T, Rivard C, Sanchez-Lozada LG, Roncal C, Lanaspa MA.
BMC Nephrol. 2018
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Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Reviewed
Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ.
Obesity 2017
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Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis Reviewed
Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K.
Am J Pathol. 2017
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Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Reviewed
Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ
Am J Physiol Renal Physiol. 2017
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Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study. Reviewed
Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ.
Hypertension. 2017
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Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. Reviewed
Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.
J Am Soc Nephrol. 2015
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CD147/Basigin limits lupus nephritis and TH 17 cell differentiation by inhibiting the IL-6/STAT3 pathway Reviewed
Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, Kato N, Tsuboi N, Yuzawa Y, Matsuo S, Murakami M, Maruyama S, Kadomatsu K
Arthritis Rheumatol 2015
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Midkine in nephrogenesis, hypertension and kidney diseases. Reviewed
Sato W, Sato Y.
Br J Pharmacol. 2014
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CD147/basigin reflects renal dysfunction in patients with acute kidney injury. Reviewed
Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
Clin Exp Nephrol. 2014
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Plasma CD147 reflects histological features in patients with lupus nephritis Reviewed
Maeda-Hori M, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson RJ, Matsuo S, Kadomatsu K, Maruyama S
Lupus. 2014
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Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis. Reviewed
Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.
Am J Pathol. 2013
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Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. Reviewed
Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K.
Am J Pathol. 2011
MISC 2
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Reply to 'The case for evidence-based medicine for the association between hyperuricaemia and CKD' Invited Reviewed International coauthorship
Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ.
Nat Rev Nephrol. Vol. 16 ( 7 ) page： 422 - 423 2020.7
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昇熱ストレスによる腎障害 Invited
佐藤由香
医学のあゆみ Vol. 273 ( 7 ) page： 595 - 596 2020.5
KAKENHI (Grants-in-Aid for Scientific Research) 3
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腎所属リンパ節を標的とするAKI-to-CKD transitionの新規治療戦略の構築
2023.4 - 2026.3
日本学術振興会 基盤（C)
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高温環境によるCKD発症の病態解明と細胞老化制御を介した治療標的の探索
Grant number：20K08607 2020.4 - 2023.3
佐藤 由香
Authorship：Principal investigator
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
暑い環境での体温上昇が慢性腎臓病(CKD)を惹起進展させるという新しい病態が報告されている。日本でも夏の気温上昇に伴い、熱中症の発症率・死亡率が特に高齢者で増加しており、熱ストレスによる腎障害の病態解明は本邦でも望まれる。申請者らは、繰り返す高温暴露により腎障害に進展する動物モデルを作成した。同モデルで長寿遺伝子Sirtuin１(Sirt1)の低下を認めたことから、病態への老化の関与が疑われた。そこで本研究では、まずは個体老化に注目し加齢が熱ストレス誘導性腎障害のリスクであることを老化促進マウスを使い検討する。さらに細胞老化における熱ストレスの分子病態を解明し、新たな治療標的を探索する。
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Usefulness of Basigin as a novel therapeutic target for diabetic kidney and liver diseases
Grant number：20K08632 2020.4 - 2023.3
Authorship：Coinvestigator(s)
Teaching Experience (On-campus) 2
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選択講義 よくわかる電解質酸塩基平衡 ナトリウム
2022
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糸球体疾患
2022
Social Contribution 1
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市民公開講座 腎臓病セミナー
Role(s)：Panelist
朝日新聞 2023.3