2021/07/27 更新

写真a

スギヤマ マサタカ
杉山 将隆
SUGIYAMA Masataka
所属
大学院医学系研究科 新規低侵襲画像診断法基盤開発研究寄附講座 特任助教
職名
特任助教

学位 1

  1. 医学博士 ( 2020年10月   浜松医科大学 ) 

 

論文 9

  1. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts

    Hyodo Ryota, Takehara Yasuo, Mizuno Takashi, Ichikawa Kazushige, Ishizu Yoji, Sugiyama Masataka, Naganawa Shinji

    HEPATOLOGY RESEARCH   51 巻 ( 3 ) 頁: 343 - 349   2021年3月

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    記述言語:日本語   出版者・発行元:Hepatology Research  

    Diagnosis and severity assessments of portosystemic shunts (PSSs) are important because the pathology sometimes results in severe hepatic encephalopathy, which can be treated almost completely by shunt embolization. At present, morphological assessment of PSS is performed mainly by computed tomography, and ultrasound is used for blood flow assessment. In two cases of PSS-related hepatic encephalopathy, we used time-resolved 3D cine phase-contrast (4D-flow) magnetic resonance imaging (MRI) to assess blood flow before and after shunt embolization. Before the intervention, blood flow in the main trunk of the superior mesenteric vein was mostly hepatofugal. However, post-interventional 4D-flow MRI revealed hepatopetal superior mesenteric vein flow with significantly increased portal vein blood flow. 4D-flow MRI is an ideal adjunct to Doppler ultrasonography, allowing for objective and visual assessment of morphology and blood flow of the portal venous system, including PSSs, and is useful in determining the indications for, and outcome of, PSS embolization.

    DOI: 10.1111/hepr.13616

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  2. Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound

    Suzuki Katsunori, Takehara Yasuo, Sakata Mayu, Kawate Masanori, Ohishi Naoki, Sugiyama Kosuke, Akai Toshiya, Suzuki Yuhi, Sugiyama Masataka, Kawamura Takafumi, Morita Yoshifumi, Kikuchi Hirotoshi, Hiramatsu Yoshihiro, Yamamoto Masayoshi, Nasu Hatsuko, Johnson Kevin, Wieben Oliver, Kurachi Kiyotaka, Takeuchi Hiroya

    PLOS ONE   16 巻 ( 1 ) 頁: e0245878   2021年1月

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    記述言語:日本語   出版者・発行元:PLoS ONE  

    Respiratory-gated four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) is magnetic resonance (MR) imaging technique that enables analysis of vascular morphology and hemodynamics in a single examination using cardiac phase resolved 3D phase-contrast magnetic resonance imaging. The present study aimed to assess the usefulness of 4D PC-VIPR for the superior mesenteric artery (SMA) flowmetry before and after flow increase was induced by the herbal medicine Daikenchuto (TJ-100) by comparing it with Doppler ultrasound (DUS) as a current standard. Twenty healthy volunteers were enrolled in this prospective single-arm study. The peak cross-sectionally averaged velocity was measured by 4D PC-VIPR, peak velocity was measured by DUS, and flow volume (FV) of SMA and aorta were measured by 4D PC-VIPR and DUS 25 min before and after the peroral administration of TJ-100. The peak cross-sectionally averaged velocity, peak velocity, and FV of SMA measured by 4D PC-VIPR and DUS significantly increased after administration of TJ-100 (4D PC-VIPR: the peak cross-sectionally averaged velocity; p = 0.004, FV; p = 0.035, DUS: the peak velocity; p = 0.003, FV; p = 0.010). Furthermore, 4D PC-VIPR can analyze multiple blood vessels simultaneously. The ratio of the SMA FV to the aorta, before and after oral administration on the 4D PC-VIPR test also increased (p = 0.015). The rate of change assessed by 4D PC-VIPR and DUS were significantly correlated (the peak cross-sectionally averaged velocity and peak velocity: r = 0.650; p = 0.005, FV: r = 0.659; p = 0.004). Retrospective 4D PC-VIPR was a useful modality for morphological and hemodynamic analysis of SMA.

    DOI: 10.1371/journal.pone.0245878

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  3. Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer

    Karayama Masato, Yoshizawa Nobuko, Sugiyama Masataka, Mori Kazutaka, Yasui Hideki, Hozumi Hironao, Suzuki Yuzo, Furuhashi Kazuki, Fujisawa Tomoyuki, Enomoto Noriyuki, Nakamura Yutaro, Inui Naoki, Goshima Satoshi, Suda Takafumi, Takehara Yasuo

    LUNG CANCER   143 巻   頁: 47 - 54   2020年5月

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    記述言語:日本語   出版者・発行元:Lung Cancer  

    Objectives: Conventional evaluation of anti-tumor activity on the basis of tumor size is inadequate for immune checkpoint inhibitors (ICIs). We therefore aimed to assess the usefulness of intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) for evaluation of the therapeutic efficacy of ICIs. Materials and methods: A chest IVIM-MRI was performed before and 2, 4, and 8 weeks after administration of ICIs in patients with advanced non-small-cell lung cancer. Apparent diffusion coefficient (ADC), skewness of ADC (ADCskew), kurtosis of ADC (ADCkurt), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were evaluated at each evaluation point and changes from the baseline (Δ). Results: Twenty patients were enrolled in this study. An increased ADC 8 weeks and decreased ADCkurt and ΔADCkurt 4 weeks after ICIs was associated with objective responses and longer progression-free survival (PFS). A decreased ΔADCskew at 4 weeks was associated with objective responses, disease control, and longer PFS and overall survival. There was no correlation between the efficacy of ICIs and D, D* and f. All of three patients who had pseudoprogression had decreased ΔADCskew at 4 weeks and two of them had decreased ΔADCkurt at 4 weeks. Inversely, all five patients who had progressive disease (PD) did not have increased ΔADCskew at 4 weeks and only one of them had decreased ΔADCkurt at 4 weeks. Conclusions: Changes in histograms of ADC may be useful for predicting long-term efficacy and distinguishing between pseudoprogression and actual PD after ICIs.

    DOI: 10.1016/j.lungcan.2020.03.013

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  4. Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics

    Sugiyama Masataka, Takehara Yasuo, Kawate Masanori, Ooishi Naoki, Terada Masaki, Isoda Haruo, Sakahara Harumi, Naganawa Shinji, Johnson Kevin M., Wieben Oliver, Wakayama Tetsuya, Nozaki Atsushi, Kabasawa Hiroyuki

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   19 巻 ( 4 ) 頁: 366 - 374   2020年

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    記述言語:日本語   出版者・発行元:Magnetic Resonance in Medical Sciences  

    Purpose: 2D cine phase contrast (PC)-MRI is a standard velocimetry for the superior mesenteric artery (SMA); however, the optimal localization of the measurement plane has never been fully discussed previ-ously. The purpose of this Institutional Review Board approved prospective and single arm study is to test whether flow velocimetry of the SMA with combined use of 2D cine PC-MRI and meal challenge is dependent on the localizations of the measurement planes and to seek optimal section for velocimetry. Methods: Seven healthy volunteers underwent cardiac phase resolved ECG gated 2D cine PC-MRI pre-and 30 min post-meal challenge at three measurement planes: proximal, curved mid section and distal straight section of the SMA at 3T. 4D Flow using 3D cine PC-MRI with vastly undersampled isotropic projection imaging (PC VIPR) was also performed right after 2D cine PC-MRI to delineate the flow dynamics within the SMA using streamline analysis. Two radiologists measured flow velocities, and rated the appearances of the abnormal flow in the SMA on streamlines derived from the 4D Flow and the computational fluid dynamics (CFD). Results: 2D cine PC-MRI measured increased temporally averaged flow velocity (mm/s) after the meal challenge only in the proximal (129.3 vs. 97.8, P = 0.0313) and distal section (166.9 vs. 96.2, P = 0.0313), not in the curved mid section (113.1 vs. 85.5, P = 0.0625). The average velocities were highest and their standard errors (8.5–26.5) were smallest at the distal straight section both before and after the meal challenge as compared with other sections. The streamline analysis depicted more frequent appearances of vertical or helical flow in the curved mid section both on 4D Flow and CFD (κ: 0.27–0.68). Conclusion: SMA velocimetry with 2D cine PC-MRI was dependent on the localization of the measurement planes. Distal straight section, not in the curved mid section is recommended for MR velocimetry.

    DOI: 10.2463/mrms.mp.2019-0089

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  5. Flow dynamics of type II endoleaks can determine sac expansion after endovascular aneurysm repair using four-dimensional flow-sensitive magnetic resonance imaging analysis

    Katahashi Kazuto, Sano Masaki, Takehara Yasuo, Inuzuka Kazunori, Sugiyama Masataka, Alley Marcus T., Takeuchi Hiroya, Unno Naoki

    JOURNAL OF VASCULAR SURGERY   70 巻 ( 1 ) 頁: 107-+   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jvs.2018.09.048

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  6. Improved blood flow after percutaneous transluminal septal myocardial ablation visualized by 4D flow cardiac magnetic resonance in a case of hypertrophic obstructive cardiomyopathy.

    Suwa K, Akita K, Iguchi K, Sugiyama M, Maekawa Y

    European heart journal cardiovascular Imaging   19 巻 ( 12 ) 頁: 1389   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ehjci/jey130

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  7. Four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) MR evaluation of the renal arteries in transplant recipients: Preliminary results

    Motoyama Daisuke, Ishii Yasuo, Takehara Yasuo, Sugiyama Masataka, Yang Wang, Nasu Hatsuko, Ushio Takasuke, Hirose Yuko, Ohishi Naoki, Wakayama Tetsuya, Kabasawa Hiroyuki, Johnson Kevin, Wieben Oliver, Sakahara Harumi, Ozono Seiichiro

    JOURNAL OF MAGNETIC RESONANCE IMAGING   46 巻 ( 2 ) 頁: 595-603   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jmri.25607

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  8. Validation of numerical simulation methods in aortic arch using 4D Flow MRI.

    Miyazaki S, Itatani K, Furusawa T, Nishino T, Sugiyama M, Takehara Y, Yasukochi S

    Heart and vessels   32 巻 ( 8 ) 頁: 1032-1044   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00380-017-0979-2

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  9. Characterizing saccular aortic arch aneurysms from the geometry-flow dynamics relationship.

    Natsume K, Shiiya N, Takehara Y, Sugiyama M, Satoh H, Yamashita K, Washiyama N

    The Journal of thoracic and cardiovascular surgery   153 巻 ( 6 ) 頁: 1413-1420.e1   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jtcvs.2016.11.032

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