Faculty Profiles - HAYASHI Gosuke

Papers - HAYASHI Gosuke

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Genotyping by allele-specific L-DNA-tagged PCR.

Hayashi G, Hagihara M, Nakatani K

Journal of biotechnology Vol. 135 ( 2 ) page： 157-60 - 60 2008.6

RNA aptamers that reversibly bind to photoresponsive peptide.

Hayashi G, Hagihara M, Nakatani K

Nucleic acids symposium series (2004) ( 52 ) page： 703-4 - 4 2008

Photoregulation of a peptide-RNA interaction on a gold surface.

Hayashi G, Hagihara M, Dohno C, Nakatani K

Journal of the American Chemical Society Vol. 129 ( 28 ) page： 8678-9 - 9 2007.7

Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging.

Hayashi G, Hagihara M, Kobori A, Nakatani K

Chembiochem : a European journal of chemical biology Vol. 8 ( 2 ) page： 169-71 - 71 2007.1

Reversible regulation of binding between a photoresponsive peptide and its RNA aptamer.

Hayashi G, Hagihara M, Dohno C, Nakatani K

Nucleic acids symposium series (2004) ( 51 ) page： 93-4 - 4 2007

N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA.

Suda H, Kobori A, Zhang J, Hayashi G, Nakatani K

Bioorganic & medicinal chemistry Vol. 13 ( 14 ) page： 4507-12 - 12 2005.7

Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.

Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C

Nature chemical biology Vol. 1 ( 1 ) page： 39-43 - 43 2005.6

Application of L-DNA as a molecular tag.

Hayashi G, Hagihara M, Nakatani K

Nucleic acids symposium series (2004) ( 49 ) page： 261-2 - 2 2005

Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.

Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C

Nucleic acids symposium series (2004) ( 49 ) page： 49-50 - 50 2005

Detection of guanine-adenine mismatches by surface plasmon resonance sensor carrying naphthyridine-azaquinolone hybrid on the surface. International journal

Hagihara S, Kumasawa H, Goto Y, Hayashi G, Kobori A, Saito I, Nakatani K

Nucleic acids research Vol. 32 ( 1 ) page： 278-86 - 86 2004

Language：English Publishing type：Research paper (scientific journal)

We have discovered a new molecule naphthyridine-azaquinolone hybrid (Npt-Azq) that strongly stabilized the guanine-adenine (G-A) mismatch in duplex DNA. In the presence of Npt-Azq, the melting temperature (T(m)) of 5'-d(CTA ACG GAA TG)-3'/3'-d(GAT TGA CTT AC)-5' containing a single G-A mismatch increased by 15.4 degrees C, whereas fully matched duplex increased its T(m) only by 2.2 degrees C. Npt-Azq was immobilized on the sensor surface for the surface plasmon resonance (SPR) assay to examine SPR detection of duplexes containing a G-A mismatch. Distinct SPR signals were observed when 27mer DNA containing a G-A mismatch was analyzed by the Npt-Azq immobilized sensor surfaces, whereas the signal of the fully matched duplex was approximately 6-fold weaker in intensity. The SPR signals for the G-A mismatch were proportional to the concentration of DNA in a range up to 1 microM, confirming that the SPR signal is in fact due to the binding of the G-A mismatch to Npt-Azq immobilized on the surface. Examination of all 16 G-A mismatches regarding the flanking sequence revealed that the sensor surface reported here is applicable to eight flanking sequences, covering 50% of all possible G-A mismatches.

DOI： 10.1093/nar/gkh171

PubMed

SPR fingerprinting of mismatched base pair.

Kobori A, Peng T, Hayashi G, Nakatani K

Nucleic acids symposium series (2004) ( 48 ) page： 129-30 - 30 2004

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Papers - HAYASHI Gosuke