Updated on 2021/04/19

写真a

 
TAKEUCHI Kenji
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Associate professor
Title
Associate professor
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Degree 2

  1. 博士(歯学) ( 2013.3   東北大学 ) 

  2. 学士(歯学) ( 2009.3   東北大学 ) 

Research Interests 12

  1. 疫学

  2. 予防医学

  3. 社会疫学

  4. 公衆衛生学

  5. 笑い

  6. 介護保険

  7. ソーシャルキャピタル

  8. 口腔ケア

  9. 高齢者

  10. COPD

  11. 認知症

  12. 歯周病

Research Areas 2

  1. Life Science / Medical management and medical sociology

  2. Life Science / Social dentistry

Current Research Project and SDGs 3

  1. 口腔の健康から目指す健康寿命の延伸

  2. 労働・就業環境が歯科疾患にもたらす影響の男女差

  3. 社会経済状況による加熱式タバコの受動喫煙格差

Research History 4

  1. Nagoya University   Associate professor

    2019.3

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    Country:Japan

  2. Kyushu University   Section of Preventive and Public Health Dentistry, Faculty of Dental Science   Collaborative Researcher

    2019.3

  3. Kyushu University

    2018.4 - 2019.2

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    Country:Japan

  4. Kyushu University   Assistant Professor

    2013.4 - 2019.2

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    Country:Japan

Education 2

  1. Tohoku University   Division of Dental Science   Department of International and Community Oral Health

    2009.4 - 2013.3

  2. Tohoku University

    2003.4 - 2009.3

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    Country: Japan

Professional Memberships 5

  1. 日本疫学会

  2. THE INTERNATIONAL ASSOCIATION FOR DENTAL RESEARCH

  3. 日本歯科衛生学会

  4. 日本公衆衛生学会

  5. 日本口腔衛生学会

Committee Memberships 11

  1. 日本疫学会   Journal of Epidemiology 編集委員  

    2021.1   

  2. ヘルスサイエンス・ヘルスケア   編集委員  

    2020.7   

  3. 愛知県   歯科衛生士人材育成検討会議 委員  

    2020.5   

  4. 日本口腔衛生学会   新型コロナウイルス感染症(COVID-19)対策検討・作業部会 委員  

    2020.5   

  5. 日本疫学会   代議員  

    2019.6   

  6. 日本口腔衛生学会   フッ化物応用委員会 委員  

    2019.5   

  7. 日本口腔衛生学会   学術委員会 委員  

    2019.5   

  8. 日本歯科衛生教育学会   研究倫理審査委員会 外部委員  

    2019.4   

  9. 日本口腔衛生学会   地域口腔保健委員会 委員  

    2017.6   

  10. 日本口腔衛生学会   査読委員  

    2013.5   

  11. 福岡市   口腔機能向上検討会 委員  

    2013.4 - 2019.3   

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Awards 3

  1. The Japanese Society for Oral Health Academic Award "LION Award".

    2019.5  

  2. The 94th IADR General Session & Exhibition. The J. Morita Post-doctoral Award for Junior Investigators for Geriatric Oral Research (First Prize)

    2016.6  

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    Award type:Award from international society, conference, symposium, etc. 

  3. 第36回九州口腔衛生学会総会. 優秀発表賞

    2014.7  

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    Award type:Award from Japanese society, conference, symposium, etc. 

 

Papers 76

  1. Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study. International journal

    Ryosuke Fujii, Takaaki Kondo, Mineko Tsukamoto, Sayo Kawai, Tae Sasakabe, Mariko Naito, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Ueyama, Yumi Hayashi, Joji Ohnishi, Nobuyuki Hamajima, Kenji Takeuchi, Kenji Wakai

    Nutrition (Burbank, Los Angeles County, Calif.)   Vol. 84   page: 111114 - 111114   2021.4

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    OBJECTIVES: Although consumption of vegetable and 100% fruit juices are an acceptable alternative for vegetable and fruit intake, information about their actual effects on kidney function is sparse. The aim of this study was to determine the association between the consumption of vegetable and fruit juices and changes in kidney function in a Japanese population over a 5-y period. METHODS: In this prospective study, we analyzed 2755 Japanese (742 men and 2013 women) individuals who participated in both the baseline and follow-up surveys in the Daiko study (a study within the Japan Multi-Institutional Collaborative Cohort study). Estimated glomerular filtration rate (eGFR) was calculated by age, sex, and serum creatinine level. For each beverage, we categorized all participants into four groups-rare (rarely consumed), low (≤2 cups/wk), moderate (3-4 cups/wk), or frequent (≥5 cups/wk) consumers of the beverage-based on a food frequency questionnaire. RESULTS: The mean baseline and follow-up eGFR (SD) were 82.4 (14.6) and 72.2 (12.6), respectively. In fully adjusted regression analyses, moderate consumption of vegetable juice was associated a lower decline in eGFR compared with the rare consumption group (β = -1.30; P = 0.01). Moreover, stratified analyses revealed that this significant association remained in those who were young, female, non-obese, normotensive, smoked cigarettes, consumed alcohol, or exercised. However, no significant association was found in analyses for fruit juices. CONCLUSIONS: This 5-y prospective study suggested an association between self-reported moderate consumption of vegetable juice and changes (possibly smaller decline) in kidney function in a relatively healthy Japanese population.

    DOI: 10.1016/j.nut.2020.111114

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  2. Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study. Reviewed

    Madoka Iwase, Keitaro Matsuo, Masahiro Nakatochi, Isao Oze, Hidemi Ito, Yuriko Koyanagi, Tomotaka Ugai, Yumiko Kasugai, Asahi Hishida, Kenji Takeuchi, Rieko Okada, Yoko Kubo, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Toshiro Takezaki, Daisaku Nishimoto, Nagato Kuriyama, Etsuko Ozaki, Sadao Suzuki, Miki Watanabe, Haruo Mikami, Yohko Nakamura, Hirokazu Uemura, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Yoshikuni Kita, Naoyuki Takashima, Masato Nagino, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

    Journal of epidemiology   Vol. 31 ( 3 ) page: 172 - 179   2021.3

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    BACKGROUND: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities. METHODS: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models. RESULTS: We found a significant association (P < 0.05/282 = 1.77 × 10-4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained, even after additional adjustment for dietary energy intake. CONCLUSIONS: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.

    DOI: 10.2188/jea.JE20190296

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  3. A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study. Reviewed International journal

    Taro Suzuki, Yasuyuki Nakamura, Keitaro Matsuo, Isao Oze, Yukio Doi, Akira Narita, Atsushi Shimizu, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Masahiro Nakatochi, Katsuyuki Miura, Naoyuki Takashima, Kiyonori Kuriki, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Rie Ibusuki, Toshiro Takezaki, Yuriko Koyanagi, Hidemi Ito, Daisuke Matsui, Teruhide Koyama, Haruo Mikami, Yohko Nakamura, Sadao Suzuki, Takeshi Nishiyama, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kenji Takeuchi, Takashi Tamura, Rieko Okada, Yoko Kubo, Yukihide Momozawa, Michiaki Kubo, Yoshikuni Kita, Kenji Wakai

    European journal of clinical nutrition   Vol. 75 ( 3 ) page: 480 - 488   2021.3

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    BACKGROUND/OBJECTIVE: Although benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish. Fish consumption may be influenced by genetic factors in addition to environmental factors. We conducted a genome-wide association study (GWAS) to find genetic variations that affect fish consumption in a Japanese population. METHODS: We performed a two-stage GWAS on fish consumption using 13,739 discovery samples from the Japan Multi-Institutional Collaborative Cohort study, and 2845 replication samples from the other population. We used a semi-quantitative food frequency questionnaire to estimate food intake. Association of the imputed variants with fish consumption was analyzed by separate linear regression models per variant, with adjustments for age, sex, energy intake, principal component analysis components 1-10, and alcohol intake (g/day). We also performed conditional analysis. RESULTS: We found 27 single nucleotide polymorphisms (SNPs) located in 12q24 and 14q32.12 that were associated with fish consumption. The 19 SNPs were located at 11 genes including six lead SNPs at the BRAP, ACAD10, ALDH2, NAA25, and HECTD4 regions on 12q24.12-13, and CCDC197 region on 14q32.12. In replication samples, all five SNPs located on chromosome 12 were replicated successfully, but the one on chromosome 14 was not. Conditional analyses revealed that the five lead variants in chromosome 12 were in fact the same signal. CONCLUSION: We found that new SNPs in the 12q24 locus were related to fish intake in two Japanese populations. The associations between SNPs on chromosome 12 and fish intake were strongly confounded by drinking status.

    DOI: 10.1038/s41430-020-00702-7

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  4. Association between periodontitis and fibrotic progression of non-alcoholic fatty liver among Japanese adults. International journal

    Kei Kuroe, Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Shino Suma, Takashi Shinagawa, Yoshihiro Shimazaki, Yoshihisa Yamashita

    Journal of clinical periodontology   Vol. 48 ( 3 ) page: 368 - 377   2021.3

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    AIM: Non-alcoholic fatty liver (NAFL) is known to develop into liver fibrosis, which increases the risk of liver cirrhosis and liver cancer. The association between periodontal condition and fibrotic progression of NAFL is unclear. This study aimed to clarify this longitudinal association. MATERIALS AND METHODS: Among 4812 participants aged 35-64 years undergoing annual health check-ups between 2003 and 2004, and follow-up 5 years later, 392 participants were diagnosed with NAFL. After excluding participants with liver fibrosis at baseline, 341 participants were followed up for 5 years. NAFL disease fibrosis score of ≥-1.455 was used to evaluate the probability of the presence of liver fibrosis. RESULTS: During the follow-up period, 10.6% of participants progressed to liver fibrosis. A higher clinical attachment level (CAL) tended to be associated with the incidence of liver fibrosis in the logistic regression analysis (odds ratio [OR] 1.82, 95% confidence interval [CI], 0.94-3.49, p = .074). The stratified analysis by obesity revealed a significant association with higher CAL in obese participants (OR 2.87, 95% CI, 1.23-6.69, p = .015), but not in non-obese participants. CONCLUSION: Higher CAL was associated with an increased probability of liver fibrosis in obese adults with NAFL.

    DOI: 10.1111/jcpe.13415

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  5. A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study. International journal

    Taro Suzuki, Yasuyuki Nakamura, Yukio Doi, Akira Narita, Atsushi Shimizu, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Aya Kadota, Katsuyuki Miura, Masahiro Nakatochi, Keitaro Tanaka, Megumi Hara, Hiroaki Ikezaki, Masayuki Murata, Toshiro Takezaki, Daisaku Nishimoto, Keitaro Matsuo, Isao Oze, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Miki Watanabe, Sadao Suzuki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai

    The British journal of nutrition     page: 1 - 9   2021.2

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    Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analysed GWAS data on confection consumption using 14 073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative FFQ to estimate food intake that was validated previously. Association of the imputed variants with confection consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1-3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/d) in addition to the above-described variables. We found 418 SNP located in 12q24 that were associated with confection consumption. SNP with the ten lowest P-values were located on nine genes including at the BRAP, ACAD10 and aldehyde dehydrogenase 2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with confections intake with genome-wide significance. In conclusion, we found a significant number of SNP located on 12q24 genes that were associated with confections intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.

    DOI: 10.1017/S0007114521000684

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  6. Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study.

    Ryosuke Fujii, Asahi Hishida, Takeshi Nishiyama, Masahiro Nakatochi, Keitaro Matsuo, Hidemi Ito, Yuichiro Nishida, Chisato Shimanoe, Yasuyuki Nakamura, Tanvir Chowdhury Turin, Sadao Suzuki, Miki Watanabe, Rie Ibusuki, Toshiro Takezaki, Haruo Mikami, Yohko Nakamura, Hiroaki Ikezaki, Masayuki Murata, Kiyonori Kuriki, Nagato Kuriyama, Daisuke Matsui, Kokichi Arisawa, Sakurako Katsuura-Kamano, Mineko Tsukamoto, Takashi Tamura, Yoko Kubo, Takaaki Kondo, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

    Journal of epidemiology     2021.2

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    BACKGROUND: Inflammation is thought to be a risk factor for kidney disease. However, discussion is controversial whether inflammatory status is either a cause or an outcome of chronic kidney disease. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using mendelian randomization (MR) approaches. METHODS: A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inverse-variance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IVCRP and IVAsian, based on SNPs previously identified in European and Asian populations. IVCRP and IVAsian explained 3.4% and 3.9% of the variation in hs-CRP, respectively. RESULTS: Using the IVCRP, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP), 95%CI: 0.000, -0.019 to 0.020 and -0.003, -0.019 to 0.014). For IVAsian, we found similar results using the IVW and the WM methods (estimate, 95% CI: -0.005, -0.020 to 0.010 and -0.004, -0.020 to 0.012). The MR-Egger method also showed no causal relationships between hs-CRP and eGFR (IVCRP: -0.008, -0.058 to 0.042; IVAsian: 0.001, -0.036 to 0.036). CONCLUSIONS: Our two-sample MR analyses with different IVs did not support a causal effect of hs-CRP on eGFR.

    DOI: 10.2188/jea.JE20200540

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  7. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study.

    Asahi Hishida, Masahiro Nakatochi, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Mineko Tsukamoto, Yuka Kadomatsu, Sadao Suzuki, Takeshi Nishiyama, Nagato Kuriyama, Isao Watanabe, Toshiro Takezaki, Daisaku Nishimoto, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Haruo Mikami, Miho Kusakabe, Isao Oze, Yuriko N Koyanagi, Yasuyuki Nakamura, Aya Kadota, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Michiaki Kubo, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai

    Nagoya journal of medical science   Vol. 83 ( 1 ) page: 183 - 194   2021.2

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    Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study, we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10-8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10-6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.

    DOI: 10.18999/nagjms.83.1.183

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  8. Body mass index and colorectal cancer risk: A Mendelian randomization study. International journal

    Shiori Suzuki, Atsushi Goto, Masahiro Nakatochi, Akira Narita, Taiki Yamaji, Norie Sawada, Ryoko Katagiri, Masao Iwagami, Akiko Hanyuda, Tsuyoshi Hachiya, Yoichi Sutoh, Isao Oze, Yuriko N Koyanagi, Yumiko Kasugai, Yukari Taniyama, Hidemi Ito, Hiroaki Ikezaki, Yuichiro Nishida, Takashi Tamura, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Kokichi Arisawa, Kenji Takeuchi, Kozo Tanno, Atsushi Shimizu, Gen Tamiya, Atsushi Hozawa, Kengo Kinoshita, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Keitaro Matsuo, Shoichiro Tsugane, Motoki Iwasaki

    Cancer science   Vol. 112 ( 4 ) page: 1579 - 1588   2021.1

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    Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we undertook a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J-CGE), comprising normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta-analysis. Mendelian randomization analysis of inverse-variance weighted method indicated that a one-unit (kg/m2 ) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06-1.20; P value <.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03-1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.

    DOI: 10.1111/cas.14824

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  9. Association between frequency of laughter and oral health among community-dwelling older adults: a population-based cross-sectional study in Japan. International journal

    Mayumi Hirosaki, Tetsuya Ohira, Kokoro Shirai, Naoki Kondo, Jun Aida, Tatsuo Yamamoto, Kenji Takeuchi, Katsunori Kondo

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation     2021.1

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    PURPOSE: Oral health has been reported to have an impact on the activities of daily life such as chewing, eating, and laughing, while psychological factors such as depression and loneliness have been reported to affect oral health. Little is known, however, about the association between laughter and oral health in older adults. This study examined the bidirectional association between the frequency of daily laughter and oral health in community-dwelling older Japanese adults. METHODS: Our cross-sectional study employed data from the 2013 Japan Gerontological Evaluation Study's self-reported survey, which included 11,239 male and 12,799 female community-dwelling independent individuals aged 65 years or older. We defined the oral health status by the number of remaining teeth. The association between the self-reported frequency of laughter (almost every day, 1-5 days per week, 1-3 days per month, or almost never) and oral health was examined using logistic regression analysis. RESULTS: The participants with 10 or more teeth were significantly more likely to laugh compared with the edentulous participants, after adjusting for all covariates. Compared with those who almost never laughed, those who laughed 1-5 days per week were significantly less likely to be edentulous. After stratifying by sex, similar results were found only in the men for both analyses. CONCLUSION: There was a significant bidirectional association between frequency of laughter and oral health that was independent of socioeconomic and lifestyle factors among older adults.

    DOI: 10.1007/s11136-020-02752-7

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  10. Number of teeth, denture wearing, and cognitive function in relation to nutritional status in residents of nursing homes. Invited Reviewed

    Suma S*, Furuta M* (*co-first authorship), Takeuchi K, Tomioka M, Iwasa Y, Yamashita Y.

    Gerodontology     2021

  11. Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study. Invited Reviewed

    Koyama T, Ozaki E, Kuriyama N, Tomida S, Yoshida T, Uehara R, Tanaka K, Hara M, Hishida A, Okada R, Kubo Y, Oze I, Koyanagi Y, Mikami H, Nakamura Y, Shimoshikiryo I, Takezaki T, Suzuki S, Otani T, Kuriki K, Takashima N, Kadota A, Arisawa K, Katsuura-Kamano S, Ikezaki H, Murata M, Takeuchi K, Wakai K.

    Journal of the American Heart Association     2021

  12. Substantial anti-gout effect conferred by common and rare variants of URAT1/SLC22A12. Invited Reviewed

    Toyoda Y, Kawamura Y, Nakayama A, Nakaoka H, Higashino T,Shimizu S, Ooyama H, Morimoto K, Uchida N, Shigesawa R, Takeuchi K, Inoue I, Ichida K, Suzuki H, Shinomiya N, Takada T, Matsuo H.

    Rheumatology     2021

  13. Dental pain and worsened socioeconomic conditions due to COVID-19 pandemic. Invited Reviewed

    Matsuyama Y, Aida J, Takeuchi K, Koyama S, Tabuchi T.

    Journal of Dental Research     2021

  14. Airflow limitation and tongue microbiota in community-dwelling elderly individuals. Invited Reviewed

    Takeshita T, Matsumoto K, Furuta M, Fukuyama S, Takeuchi K, Ogata H, Asakawa M, Kageyama S, Hata J, Ninomiya T, Inoue H, Yamashita Y.

    ERJ Open Research     2021

  15. Associations between peroxisome proliferator-activated receptor γ (PPAR-γ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults. Reviewed International journal

    Takashi Matsunaga, Mariko Naito, Guang Yin, Asahi Hishida, Rieko Okada, Sayo Kawai, Tae Sasakabe, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Takashi Tamura, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima, Kenji Wakai

    Gene   Vol. 762   page: 145019 - 145019   2020.12

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    Dyslipidemia is a well-established risk factor for cardiovascular disease. Experimental studies have reported that peroxisome proliferator-activated receptor γ (PPAR-γ) regulates adipocyte differentiation, lipid storage, and glucose metabolism. Therefore, we examined the associations between PPAR-γ polymorphisms (rs1801282, rs3856806, rs12497191, rs1151999, and rs1152003) and serum lipids in two cross-sectional studies. In the Shizuoka area of the Japan Multi-Institutional Collaborative Cohort Study, we examined 4,952 participants (3,356 men and 1,596 women) in a baseline survey and 2,245 participants (1,550 men and 695 women) in a second survey 5 years later. Outcome measures were the prevalence of dyslipidemia (low-density lipoprotein-cholesterol [LDL-C] ≥ 140 mg/dl, high-density lipoprotein-cholesterol < 40 mg/dl, triglycerides ≥ 150 mg/dl, and/or use of cholesterol-lowering drugs) and the prevalence of high LDL-C (LDL-C ≥ 140 mg/dl and/or use of cholesterol-lowering drugs). Multivariate odds ratios (ORs) were estimated by using unconditional logistic regression models. A total of 2,114 and 1,431 individuals (42.7% and 28.9%) had dyslipidemia and high LDL-C in the baseline survey, respectively, as did 933 and 716 (41.6% and 31.9%), respectively, in the second survey. In the baseline study, compared with major allele homozygotes, minor allele homozygotes of rs3856806 and rs12497191 had a 42% (OR, 0.58; 95% confidence interval (CI), 0.39-0.85) and 23% (OR, 0.77; 95% CI, 0.60-0.99) lower risk of dyslipidemia, respectively, after adjustment for potential confounding factors. In addition, minor allele homozygotes of rs3856806 had a 45% (OR, 0.55; 95% CI, 0.35-0.86) lower risk of high LDL-C. Similar risk reductions were found in the second survey. In conclusion, rs3856806 and rs12497191 polymorphisms may be related to a lower risk of dyslipidemia and high LDL-C.

    DOI: 10.1016/j.gene.2020.145019

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  16. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern. International journal

    Harumitsu Suzuki, Yasuyuki Nakamura, Keitaro Matsuo, Nahomi Imaeda, Chiho Goto, Akira Narita, Atsushi Shimizu, Naoyuki Takashima, Kenji Matsui, Katsuyuki Miura, Masahiro Nakatochi, Asahi Hishida, Takashi Tamura, Yuka Kadomatsu, Rieko Okada, Yuichiro Nishida, Chisato Shimanoe, Daisaku Nishimoto, Toshiro Takezaki, Isao Oze, Hidemi Ito, Hiroaki Ikezaki, Masayuki Murata, Daisuke Matsui, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Sadao Suzuki, Miki Watanabe, Kokichi Arisawa, Hirokazu Uemura, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Yoshikuni Kita, Kenji Takeuchi, Kenji Wakai

    European journal of clinical nutrition     2020.12

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    BACKGROUND/OBJECTIVES: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. SUBJECTS/METHODS: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1-10 omitting variants in the major histocompatibility region. RESULTS: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10-8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. CONCLUSION: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.

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  17. Longitudinal Associations of Toothbrushing With Obesity and Hyperglycemia.

    Furuta M, Takeuchi K, Takeshita T, Tanaka A, Suma S, Shinagawa T, Shimazaki Y, Yamashita Y

    Journal of epidemiology   Vol. 30 ( 12 ) page: 556 - 565   2020.12

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    <p><b>Background:</b> Toothbrushing is a health-related lifestyle habit and has been reported to contribute not only to oral health but also to some parameters of general health; however, little research has been conducted to understand the association of the frequency and timing of toothbrushing with the development of comprehensive metabolic abnormalities, with consideration of oral health condition. In this study, using longitudinal data, we examined this association in Japanese adults, adjusting for periodontal condition.</p><p><b>Methods:</b> A 5-year longitudinal study was performed with 4,537 participants between 35 and 64 years old who underwent an annual dental examination in both 2003 and 2008. Data about toothbrushing habits and metabolic abnormalities, such as obesity, hyperglycemia, diabetes, hypertension, hypertriglyceridemia, and low levels of high-density lipoprotein-cholesterol, were analyzed using Poisson regression analysis.</p><p><b>Results:</b> The percentage of participants with a toothbrushing frequency ≤1 time/day was 29.4%, and that for those not brushing their teeth at night was 21.4%. The incidences of obesity and hyperglycemia after 5 years were 5.5% and 28.4%, respectively. A toothbrushing frequency ≤1 time/day was associated with development of obesity (prevalence rate ratio [PRR] 1.77; 95% confidence interval [CI], 1.12–2.80), after adjusting for periodontal condition and potential risk factors. A significant association between not brushing teeth at night and hyperglycemia (PRR 1.30; 95% CI, 1.02–1.66) was observed in participants with toothbrushing frequency of 1 time/day. No association was found between toothbrushing habits and other metabolic abnormalities.</p><p><b>Conclusions:</b> This study suggests that toothbrushing habits are associated with the development of obesity and hyperglycemia.</p>

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  18. Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study. International journal

    Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Daisuke Matsui, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Asahi Hishida, Tae Sasakabe, Sayo Kawai, Mariko Naito, Naoyuki Takashima, Aya Kadota, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Hiroko Nakagawa-Senda, Toshiro Takezaki, Ippei Shimoshikiryo, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kiyonori Kuriki, Kokichi Arisawa, Hirokazu Uemura, Kenji Takeuchi, Kenji Wakai

    Scientific reports   Vol. 10 ( 1 ) page: 18499 - 18499   2020.10

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    There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.

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  19. Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study. Reviewed

    Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Satomi Tomida, Ritei Uehara, Yuichiro Nishida, Chisato Shimanoe, Asahi Hishida, Takashi Tamura, Mineko Tsukamoto, Yuka Kadomatsu, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Rie Ibusuki, Toshiro Takezaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Kenji Wakai

    Journal of atherosclerosis and thrombosis   Vol. 27 ( 10 ) page: 1097 - 1107   2020.10

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    AIM: Accumulating evidence reveals that sedentary behavior is associated with mortality and cardiometabolic disease; however, there are potential age and sex differences in sedentary behavior and health outcomes that have not been adequately addressed. This study aimed to determine the association of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, diabetes mellitus, and its risk factors in a large Japanese population according to age and sex. METHODS: Using data from the Japan Multi-Institutional Collaborative Cohort Study obtained from baseline surveys, data of 62,754 participants (27,930 males, 34,824 females) were analyzed. This study uses a cross-sectional design and self-administered questionnaires to evaluate sedentary time and anamnesis. For the logistic regression analysis, sedentary time <5 h/day was used as the reference and then adjusted for age, research areas, leisure-time metabolic equivalents, and alcohol and smoking status. From the analysis of anthropometric and blood examinations, 35,973 participants (17,109 males, 18,864 females) were analyzed. RESULTS: For hypertension and diabetes, sedentary time was associated with a significantly higher proportion of male participants. Both sexes were associated with a significantly higher proportion of participants with dyslipidemia. Participants who had longer sedentary time tended to have increased levels of blood pressure, triglycerides, and non-high-density lipoprotein cholesterol (HDL-C), and decreased levels of HDL-C, especially in the 60-69 years group. CONCLUSIONS: Independent of leisure-time physical activity, sedentary time was associated with cardiometabolic diseases in a large Japanese population classified by age and sex. Our findings indicate that regularly interrupting and replacing sedentary time may contribute to better physical health-related quality of life.

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  20. Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Reviewed

    Kenji Takeuchi, Mariko Naito, Sayo Kawai, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Masahiro Nakatochi, Tae Sasakabe, Shuji Hashimoto, Hidetaka Eguchi, Yukihide Momozawa, Hiroaki Ikezaki, Masayuki Murata, Norihiro Furusyo, Keitaro Tanaka, Megumi Hara, Yuichiro Nishida, Keitaro Matsuo, Hidemi Ito, Isao Oze, Haruo Mikami, Yohko Nakamura, Miho Kusakabe, Toshiro Takezaki, Rie Ibusuki, Ippei Shimoshikiryo, Sadao Suzuki, Takeshi Nishiyama, Miki Watanabe, Teruhide Koyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Yoshikuni Kita, Hirotsugu Ueshima, Kenji Matsui, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Sho Nakamura, Hiroto Narimatsu, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai

    Journal of epidemiology     2020.9

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    BACKGROUND: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene-environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. METHODS: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history, and collected peripheral blood samples. RESULTS: The baseline survey included 92,610 adults (mean age: 55.2 [9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65-69 years for men and 60-64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. CONCLUSIONS: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.

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  21. Body mass index and colorectal cancer risk in Japanese populations: a Mendelian randomization study

    Suzuki Shiori, Goto Atsushi, Nakatochi Masahiro, Narita Akira, Yamaji Taiki, Sawada Norie, Katagiri Ryoko, Hachiya Tsuyoshi, Sutoh Yoichi, Oze Isao, Koyanagi Yuriko, Kasugai Yumiko, Ito Hidemi, Ikezaki Hiroaki, Tanaka Keitaro, Tamura Takashi, Mikami Haruo, Takezaki Toshiro, Suzuki Sadao, Kuriyama Nagato, Kuriki Kiyonori, Kita Yoshikuni, Arisawa Kokichi, Takeuchi Kenji, Tanno Kozo, Shimizu Atsushi, Tamiya Gen, Hozawa Atsushi, Kinoshita Kengo, Wakai Kenji, Sasaki Makoto, Yamamoto Masayuki, Matsuo Keitaro, Tsugane Shoichiro, Iwasaki Motoki

    Cancer Science   Vol. 80 ( 16 )   2020.8

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  22. 成人における主観的な口腔健康状態と自殺を考えた経験との関連 Invited Reviewed

    野口有紀, 藤田美枝子, 竹内研時

    日本歯科衛生学会雑誌   Vol. 15 ( 1 ) page: 33 - 44   2020.8

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  23. Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal

    Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Nguyen Van Tien, Asahi Hishida, Takashi Tamura, Yoko Kubo, Mineko Tsukamoto, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Daisaku Nishimoto, Teruhide Koyama, Etsuko Ozaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Aya Kadota, Naoyuki Takashima, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Kenji Wakai

    Nutrients   Vol. 12 ( 6 )   2020.5

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    The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.

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  24. Does laughter predict onset of functional disability and mortality among older Japanese adults? the JAGES prospective cohort study. Reviewed

    Yudai Tamada*, Kenji Takeuchi* (*co-first authorship), Chikae Yamaguchi, Masashige Saito, Tetsuya Ohira, Kokoro Shirai, Katsunori Kondo

    Journal of epidemiology     2020.5

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    BACKGROUND: While laughter is broadly recognized as a good medicine, a potential preventive effect of laughter on disability and death is still being debated. Accordingly, we investigated the association between the frequency of laughter and onset of functional disability and all-cause mortality among the older adults in Japan. METHODS: The data for a 3-year follow-up cohort including 14,233 individuals (50.3% men) aged ≥ 65 years who could independently perform the activities of daily living and participated in the Japan Gerontological Evaluation Study were analyzed. The participants were classified into four categories according to their frequency of laughter (almost every day, 1-5 days/week, 1-3 days/month, and never or almost never). We estimated the risks of functional disability and all-cause mortality in each category using a Cox proportional hazards model. RESULTS: During follow-up, 605 (4.3%) individuals developed functional disability, identified by new certification for the requirement of Long-Term Care Insurance, and 659 (4.6%) deaths were noted. After adjusting for the potential confounders, the multivariate-adjusted hazard ratio of functional disability increased with a decrease in the frequency of laughter (p for trend = 0.04). The risk of functional disability was 1.42 times higher for individuals who laughed never or almost never than for those who laughed almost every day. No such association was observed with the risk of all-cause mortality (p for trend = 0.39). CONCLUSIONS: Low frequency of laughter is associated with increased risks of functional disability. Laughter may be an early predictor of functional disability later on in life.

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  25. Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal

    Naoki Choda, Kenji Wakai, Mariko Naito, Nahomi Imaeda, Chiho Goto, Kenta Maruyama, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Yoko Kubo, Rieko Okada, Sayo Kawai, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima

    Nutrition journal   Vol. 19 ( 1 ) page: 2 - 2   2020.1

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    BACKGROUND: Mental health has become a major public health issue worldwide. Biological and epidemiological studies suggest diet has a role in the prevention or cure of mental disorders. However, further research is required to elucidate the relationship between diet and mental health. This study aimed to investigate associations between dietary intake of nutrients (macronutrients, vitamins, calcium, and fatty acids) and food groups (fish, meat and chicken, dairy products, and vegetables) and mental health among middle-aged Japanese in cross-sectional and prospective studies. METHODS: In total, 9298 men and women that participated in two areas of the Japan Multi-Institutional Collaborative Cohort Study were eligible for analysis at the baseline (cross-sectional) survey. Of these, 4701 participants were followed for about 5 years and included in the follow-up (prospective) analysis. The 12-item General Health Questionnaire (GHQ) was used to assess participants' general mental health status over the past several weeks. The average intake of 46 foods over the past year was assessed by a validated food frequency questionnaire. We also evaluated lifestyle and medical factors using a self-administered questionnaire. A cross-sectional logistic regression analysis was performed to estimate odds ratios for a GHQ score ≥ 4 (poor mental health) according to dietary intake of foods/nutrients at baseline. The prospective study used baseline dietary and lifestyle factors and GHQ scores at follow-up. RESULTS: The cross-sectional logistic regression analysis showed vegetables, protein, calcium, vitamin D, carotene and n-3 highly-polyunsaturated fatty acids were inversely associated with a GHQ score ≥ 4. On the other hand, mono-unsaturated fatty acids showed a positive association with higher GHQ score. The prospective logistic regression analysis found dairy products, calcium, vitamin B2, and saturated fatty acids were inversely correlated with a GHQ score ≥ 4. Calcium was associated with GHQ scores in both the cross-sectional and follow-up studies. In the follow-up study, the multivariable-adjusted odds ratio for a GHQ score ≥ 4 was 0.71 (95% confidence interval, 0.55-0.92) for the highest versus lowest quartiles of calorie-adjusted dietary calcium intake. CONCLUSION: Consuming particular nutrients and foods, especially calcium and dairy products, may lead to better mental health in Japanese adults.

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  26. Dentist gender-related differences in patients' oral health behaviour. Reviewed

    Kenji Takeuchi, Yuki Noguchi, Yukie Nakai, Toshiyuki Ojima, Yoshihisa Yamashita

    Journal of oral science   Vol. 62 ( 1 ) page: 32 - 35   2020

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    This study aimed at determining whether oral health behavior differs between patients regularly checked by male and female dentists. The analysis was based on a cross-sectional survey of 354 Japanese community residents (median age = 54 years; 145 men and 209 women) conducted in a municipality from January to February 2017. Data on demographic characteristics and factors associated with oral health behavior were obtained through self-administered questionnaires. The association between regular dentist gender and patients' regular dental care check-up and interdental cleaning performance was examined after adjusting for potential confounders. Among respondents, 88.7% and 11.3% reported having male and female regular dentists, respectively. In a multivariate logistic regression model, patients regularly checked by female dentists had an increased likelihood of visiting their dentist for dental care check-up at least once every year (odds ratio [OR] = 2.23, 95% confidence interval [CI] = 1.09-4.55)and using an interdental cleaner (OR = 2.62, 95% CI = 1.03-6.71) compared to those regularly checked by male dentists. Patients regularly checked by female dentists tended to have more preventive oral health behaviors than those regularly checked by male dentists. These findings suggest that dentist gender has important clinical implications for patients' oral health behavior.

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  27. Dental Visit Behavior of Patients during the COVID-19 Pandemic: Which People Exhibit the most Anxiety?

    KOYAMA Shihoko, TAKEUCHI Kenji

    JOURNAL OF DENTAL HEALTH   Vol. 70 ( 3 ) page: 168 - 174   2020

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    <p> COVID-19 was declared a pandemic by the World Health Organization in March 2020, and the Japanese government declared a state of emergency in the country soon after. Dental treatments may pose a high risk of transmission and contraction of the coronavirus SARS-CoV-2, because many routine dental procedures can potentially transmit the virus through the use of aerosols. In this study, we investigated the dental visit behavior of the general population during the continuing COVID-19 pandemic, and explored the characteristics of those individuals who experienced marked anxiety regarding dental visits due to fear of nosocomial infection. We analyzed web-based questionnaire survey data on the general population, with 1,885 participants (798 women) who responded between May 1 2020 and May 10 2020. We tabulated three items related to the basic characteristics and five items related to dental visits. To examine the association between strong dental visit anxiety and its predictors, the prevalence ratio (PR) and 95% confidence interval (CI) were calculated using Poisson regression. After excluding the participants who had no plans to visit the dentist, 47.2% of the remaining 688 participants did not visit the dentist after the state of emergency was declared in Japan due to cancellation or change of appointment. There were 454 respondents (24.1% of the total participants) who reported feeling marked anxiety regarding dental visits. The results of the multivariate Poisson regression analysis showed that women had a significantly higher PR (PR=1.25, 95% CI=1.06; 1.48) for marked anxiety than men. Further, those who visited only when they experienced troubling symptoms, had a significantly higher PR (PR=1.36, </p><p>95% CI=1.15; 1.61) for marked anxiety than those who visited a few times a year. Our findings may be a valuable resource for predicting the future dental visit behavior of patients in the post-COVID-19 era.</p>

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  28. Impact of PSCA polymorphisms on the risk of duodenal ulcer. Reviewed

    Yoshiaki Usui, Keitaro Matsuo, Isao Oze, Tomotaka Ugai, Yuriko Koyanagi, Yoshinobu Maeda, Hidemi Ito, Asahi Hishida, Kenji Takeuchi, Takashi Tamura, Mineko Tsukamoto, Yuka Kadomatsu, Megumi Hara, Yuichiro Nishida, Ippei Shimoshikiryo, Toshiro Takezaki, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Sadao Suzuki, Miki Watanabe, Hiroko Nakagawa-Senda, Haruo Mikami, Yohko Nakamura, Kokichi Arisawa, Hirokazu Uemura, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Hiroaki Ikezaki, Masayuki Murata, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

    Journal of epidemiology   Vol. 31 ( 1 ) page: 12 - 20   2019.12

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    BACKGROUND: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. METHODS: PSCA six SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CI) for association between the SNPs and risk of DU/GU. RESULTS: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P=2.28×10-6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. CONCLUSIONS: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.

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  29. Path from epidemiological studies to policy Reviewed

    Kenji Takeuchi

    Health Science and Health Care   Vol. 19 ( 2 ) page: 62 - 65   2019.12

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  30. Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease Reviewed

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

    Journal of Dental Research   Vol. 98 ( 5 ) page: 534 - 540   2019.3

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  31. Denture Wearing Moderates the Association between Aspiration Risk and Incident Pneumonia in Older Nursing Home Residents: A Prospective Cohort Study. Reviewed

    Takeuchi K, Izumi M, Furuta M, Takeshita T, Shibata Y, Kageyama S, Okabe Y, Akifusa S, Ganaha S, Yamashita Y

    International journal of environmental research and public health   Vol. 16 ( 4 )   2019.2

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    DOI: 10.3390/ijerph16040554

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  32. Characteristics of the Salivary Microbiota in Patients With Various Digestive Tract Cancers. Reviewed

    Kageyama S, Takeshita T, Takeuchi K, Asakawa M, Matsumi R, Furuta M, Shibata Y, Nagai K, Ikebe M, Morita M, Masuda M, Toh Y, Kiyohara Y, Ninomiya T, Yamashita Y

    Frontiers in microbiology   Vol. 10   page: 1780   2019

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  33. Effects of xylitol-containing chewing gum on the oral microbiota Reviewed

    Takeuchi K, Asakawa M, Hashiba T, Takeshita T, Saeki Y, Yamashita Y

    Journal of oral science   Vol. 60 ( 4 ) page: 588 - 594   2018.11

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  34. Comparison of the periodontal condition in Korean and Japanese adults: a cross-sectional study Reviewed

    Furuta M, Takeuchi K, Shimazaki Y, Takeshita T, Shibata Y, Hata J, Yoshida D, Park DY, Ninomiya T, Yamashita Y

    BMJ Open   Vol. 8 ( 11 )   2018.11

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    DOI: 10.1136/bmjopen-2018-024332

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  35. Tongue Microbiota and Oral Health Status in Community-Dwelling Elderly Adults. Reviewed

    Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y

    mSphere   Vol. 3 ( 4 )   2018.8

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  36. Decreased cognitive function is associated with dysphagia risk in nursing home older residents Reviewed

    Yatabe N*, Takeuchi K*, (*co-first authorship), Izumi M, Furuta M, Takeshita T, Shibata Y, Suma S, Kageyama S, Ganaha S, Tohara H, Yamashita Y

    Gerodontology   Vol. 35 ( 4 ) page: 376 - 381   2018.7

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  37. Periodontitis modifies the association between smoking and chronic obstructive pulmonary disease in Japanese men Reviewed

    Jane Harland, Michiko Furuta, Kenji Takeuchi, Shunichi Tanaka, Yoshihisa Yamashita

    Journal of Oral Science   Vol. 60 ( 2 ) page: 226 - 231   2018.6

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    Periodontitis was reported to be associated with chronic obstructive pulmonary disease (COPD), and both diseases are related to smoking. To identify associations between periodontitis, smoking, and COPD, this cross-sectional study enrolled 1474 Japanese men (mean age 55.2 ± 8.9 years) surveyed between 2003 and 2006. Periodontal status was evaluated by using the community periodontal index. Periodontitis was defined as the presence of at least one sextant with a pocket depth ≥4 mm. Lung function was measured by spirometry, and COPD was defined as ratio of forced expiratory volume after 1 second to forced vital capacity of &lt
    0.70. Logistic regression analysis showed that the association between COPD and smoking was stronger for men with periodontitis (odds ratio 2.45
    95% confidence interval 1.37-4.37) than for those without periodontitis (odds ratio 1.64
    95% confidence interval 0.91-2.94), after adjusting for age, number of present teeth, body mass index, alcohol intake, occupation, hypertension, and diabetes. The association between smoking and COPD was significant for men with periodontitis but was weaker for those without periodontitis. These findings suggest that periodontitis modifies the association between smoking and COPD.

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  38. Tooth loss, swallowing dysfunction and mortality in Japanese older adults receiving home care services Reviewed

    Michiko Furuta, Kenji Takeuchi, Munehisa Adachi, Toshinori Kinoshita, Nobuoki Eshima, Sumio Akifusa, Takeshi Kikutani, Yoshihisa Yamashita

    Geriatrics and Gerontology International   Vol. 18 ( 6 ) page: 873 - 880   2018.6

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    Aim: Severe tooth loss and swallowing dysfunction occur more frequently in dependent older adult populations. Poor oral health and functional status are expected to have a negative impact on general health. We examined whether mortality is related to the number of teeth and swallowing function in dependent older Japanese individuals receiving home care services. Methods: Older adults aged ≥65 years who were receiving home care were included. The planned follow-up period was 3 years. Baseline data on the number of teeth, swallowing function, nutritional status, cognitive ability and activities of daily living were collected. Results: A total of 259 participants (mean age 85.0 ± 7.7 years) were enrolled. The mean length of follow up was 26.2 months. Severe tooth loss (≤9 present teeth) and swallowing dysfunction were observed in 68.0% and 32.0% of the participants, respectively. Cox's proportional hazards regression model showed that participants with both ≤9 teeth and swallowing dysfunction were at a higher risk of mortality compared with those with both ≥10 teeth and normal swallowing function (hazard ratio 2.89, 95% confidence interval 1.22–6.83). A significant interaction among severe tooth loss, swallowing dysfunction and mortality risk was observed. Conclusions: Severe tooth loss and swallowing dysfunction were associated with increased mortality. The present study suggests that the maintenance of oral health and swallowing function has a positive effect on general health. Therefore, attention should be given to both tooth loss and swallowing function in dependent older adult populations. Geriatr Gerontol Int 2018
    18: 873–880.

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  39. Relationship of toothbrushing to metabolic syndrome in middle-aged adults Reviewed

    Akihiko Tanaka, Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Shino Suma, Takashi Shinagawa, Yoshihiro Shimazaki, Yoshihisa Yamashita

    Journal of Clinical Periodontology   Vol. 45 ( 5 ) page: 538 - 547   2018.5

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    Aim: To examine the effect of toothbrushing on the development of metabolic syndrome (MetS), including assessment of periodontal status, in middle-aged adults. Methods: This 5-year follow-up retrospective study was performed in 3,722 participants (2,897 males and 825 females) aged 35–64 years who underwent both medical check-ups and dental examinations. Metabolic components included obesity, elevated triglycerides, blood pressure, fasting glucose and reduced high-density lipoprotein. Toothbrushing frequency was assessed using a questionnaire. Periodontal disease was defined as having at least one site with a pocket depth of ≥4 mm. Logistic regression analysis was performed to evaluate the relationship between toothbrushing frequency at the baseline examination and the development of MetS (≥3 components). Results: During follow-up, 11.1% of participants developed MetS. After adjusting for potential confounders including periodontal disease, participants with more frequent daily toothbrushing tended to have significantly lower odds of developing MetS (p for trend =.01). The risk of development of MetS was significantly lower in participants brushing teeth ≥3 times/day than in those brushing teeth ≤1 time/day (odds ratio = 0.64, 95% confidence interval = 0.45–0.92). Conclusions: Frequent daily toothbrushing was associated with lower risk of development of MetS.

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  40. Periodic and Regional Differences in Estimated Consultation Rate for Periodontal Disease Screening in Japan Reviewed

    YATABE Naoko, FURUTA Michiko, TAKEUCHI Kenji, SUMA Shino, FUCHIDA Shinya, YAMAMOTO Tatsuo, YAMASHITA Yoshihisa

    JOURNAL OF DENTAL HEALTH   Vol. 68 ( 2 ) page: 92 - 100   2018.4

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    <p> The Japanese Ministry of Health, Labour, and Welfare has been conducting periodontal disease screening as a part of senior health services since 1995, and as an independent medical examination for individuals aged between 40 and 50 years since 2000. This service has been extended for individuals aged between 60 and 70 years since 2004. The consultation rate for periodontal disease screening in Japan has not been reported recently, and so its current status is unknown. In this study, we estimated and assessed periodic and regional differences in the consultation rate for periodontal disease screening over a period of 15 years.</p><p> We calculated the consultation rate for periodontal disease screening by dividing the number of individuals screened for periodontal disease (as recorded in the regional health care and health promotion service report), by the total population (as per the Basic Resident Register and multiplying by 100), from the year 2000 to 2015. At the national level, the consultation rate was 1.27% in 2000, 2.74% in 2005, 3.34% in 2010, and 4.30% in 2015. The highest rate in a prefecture was 13.33% and the lowest rate was 0.34% reveling that consultation rates differed markedly among prefectures. Multiple linear regression analysis that factored in socio-demographic variables revealed that prefectures with larger total numbers of oral examinations and health guidance sessions (partial correlation coefficient= 0.356; <i>p</i>=0.016), a larger proportion of health care costs (partial correlation coefficient=0.295; <i>p</i>=0.049), and a higher level of available funds (partial correlation coefficient=0.337; <i>p</i>=0.024), had higher consultation rates.</p><p> It was concluded that the total consultation rate showed an increasing trend, while the regional differences widened. The total consultation rate may increase in the future by focusing efforts on improving regional consultation rates.</p>

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  41. Association of Regional Inequality in 12-year-olds' Decayed, Missing, or Filled Permanent Teeth in Fukuoka Prefecture with Community-level Socioeconomic Status Reviewed

    OKABE Yuka, TAKEUCHI Kenji, FURUTA Michiko, HIRASE Hisayoshi, MATSUDA Kouichi, SAKATA Hitoshi, SUGIHARA Eiji, YAMASHITA Yoshihisa

    JOURNAL OF DENTAL HEALTH   Vol. 68 ( 1 ) page: 15 - 20   2018.1

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    <p> The number of dental caries in school children is decreasing every year, but it is still high in Japan. Recently, it was reported that the social context, such as socioeconomic status, influences the development of dental caries. However, few studies have estimated caries-related regional inequality in school children or assessed the association between dental caries in school children and the community-level socioeconomic status. The purpose of this ecological study was to examine caries-related regional inequality and impact of the socioeconomic status on the risk of dental caries of 12-year-olds in municipalities in Fukuoka Prefecture. Data on 12-year-olds' decayed, missing, or filled permanent teeth (DMFT), which indicates experience of dental caries affecting their permanent teeth, were obtained from the reports of school dental health examinations in 60 municipalities of Fukuoka Prefecture. Data on the community-level socioeconomic status in each municipality, which included the ratio of persons employed in the tertiary industry, unemployment rate, number of grocery stores per 100,000 residents, number of dental clinics per 100,000 residents, and population aging rate, were obtained from national statistical data. We applied stepwise multiple regression analysis to determine the association between 12-year-olds' DMFT and the community-level socioeconomic status. The results of the analysis showed that the ratio of persons employed in the tertiary industry (<i>p</i>=0.007) and number of dental clinics per 100,000 residents (<i>p</i>=0.044) were associated with lower DMFT, whereas the number of grocery stores per 100,000 residents was associated with higher DMFT (<i>p</i>=0.010). This study suggests that there is regional inequality in 12-year-olds' DMFT among municipalities in Fukuoka Prefecture, and there are significant effects of the community-level socioeconomic status on 12-year-olds' DMFT in municipalities. Efforts of public health organizations in consideration of the community-level socioeconomic status are thought to be important to reduce regional inequality in oral health.</p>

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  42. 歯周疾患検診受診率の推移とその地域差に関する検討 Reviewed

    矢田部尚子, 古田美智子, 竹内研時, 須磨紫乃, 渕田慎也, 山本龍生, 山下喜久

    口腔衛生学会雑誌   Vol. 68 ( 1 ) page: 45 - 45   2018.1

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  43. Characterization of oral microbiota and acetaldehyde production. Reviewed

    Yokoyama S*, Takeuchi K* (*co-first authorship), Shibata Y, Kageyama S, Matsumi R, Takeshita T, Yamashita Y

    Journal of oral microbiology   Vol. 10 ( 1 ) page: 1492316   2018

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  44. Periodontal status and lung function decline in the community: the Hisayama study Reviewed

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

    Scientific Reports   Vol. 8 ( 1 ) page: 13354   2018

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    DOI: 10.1038/s41598-018-31610-3

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  45. Gender-dependent associations between occupational status and untreated caries in Japanese adults Reviewed

    Yuriko HARADA, Kenji TAKEUCHI, Michiko FURUTA, Akihiko TANAKA, Shunichi TANAKA, Naohisa WADA, Yoshihisa YAMASHITA

    Industrial Health   Vol. 56 ( 6 ) page: 539 - 544   2018

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  46. Gender-dependent associations between occupational status and untreated caries in Japanese adults

    Harada Y*, Takeuchi K* (*co-first authorship), Furuta M, Tanaka A, Tanaka S, Wada N, Yamashita Y.

    INDUSTRIAL HEALTH   Vol. 56 ( 6 ) page: 539 - 544   2018

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  47. Swallowing disorders and 1-year functional decline in community-dwelling older adults receiving home care Reviewed

    K. Takeuchi, M. Furuta, Y. Okabe, S. Suma, T. Takeshita, S. Akifusa, M. Adachi, T. Kinoshita, T. Kikutani, Y. Yamashita

    JOURNAL OF ORAL REHABILITATION   Vol. 44 ( 12 ) page: 982 - 987   2017.12

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    The purpose of this study was to clarify the effect of swallowing disorders on functional decline in community-dwelling older adults receiving home care. This was a 1-year follow-up survey of 176 individuals 60years living at home and receiving homecare services, without total dependence in basic daily living activities, in two mid-sized municipalities in Fukuoka, Japan. Functional decline was measured using the Barthel index (BI), and the primary outcome was total dependence in basic daily living activities (BI20 points). Swallowing function was assessed using cervical auscultation, and the primary predictor was swallowing disorders. Logistic regression models were used to assess univariate and multivariate associations between baseline swallowing function and functional decline during follow-up. During follow-up 16 (9.1%), the participants became totally dependent in basic daily living activities. The participants with swallowing disorders had 6.41 times higher odds of total dependence in basic daily living activities compared to participants with normal swallowing function. After adjusting for potential confounders, swallowing disorders were significantly associated with higher odds of total dependence in basic daily living activities (odds ratio=5.21, 95% confidence interval=1.33-20.44). Regarding swallowing disorders, the corresponding population attributable fraction (%) of the incidence of total dependence in basic daily living activities was 50.4%. The current findings demonstrated that swallowing disorders were associated with greater risk of functional decline in basic daily living activities among older adults living at home and receiving home nursing care. Maintenance and improvement of swallowing function may prevent late-life functional decline.

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  48. Relationships of variations in the tongue microbiota and pneumonia mortality in nursing home residents. Reviewed

    Kageyama S, Takeshita T, Furuta M, Tomioka M, Asakawa M, Suma S, Takeuchi K, Shibata Y, Iwasa Y, Yamashita Y

    The journals of gerontology. Series A, Biological sciences and medical sciences   Vol. 73 ( 8 ) page: 1097 - 1102   2017.10

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  49. Associations of Oral Health Status and Dental Health Service Utilization with Dental and Medical Expenditures Reviewed

    竹内研時, 佐藤遊洋, 須磨紫乃, 古田美智子, 岡部優花, 田中照彦, 小坂健, 山下喜久

    口腔衛生学会雑誌   Vol. 67 ( 3 ) page: 160‐171 - 171   2017.7

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    <p>It was recently reported that dental care management not only reduces the economic burden caused by dental diseases, but also helps to prevent the deterioration of lifestyle-related diseases. This study was aimed to comprehensively survey the findings to date on how the oral health status and dental health service utilization are associated with dental and medical expenditures. Investigation focused on: (1) association of the oral health status with dental and medical expenses, and (2) association of the utilization of dental health services with dental and medical expenses. An initial combination of electronic-database and hand searches yielded 32 relevant reports, which were then intensively reviewed.</p><p>(1) Many studies revealed that patients with 20 or more teeth incur lower dental costs, and those with more remaining teeth incur lower medical costs. In addition, there were reports that the presence of dental disease, primarily periodontal disease, is associated with higher dental and medical expenses. </p><p>(2) There were reports that participating in regular preventive visits to a dental clinic or dental check-ups is associated with lower dental and medical costs.</p><p>The results of this study reveal that dental and medical expenditures are particularly associated with the number of remaining teeth, and with participation in dental health activity such as regular preventive dental visits. Caries and periodontal disease are the leading causes of tooth loss: the present findings suggest that continuing regular dental check-ups from a young age focused on the prevention of such dental diseases could make a consistent contribution to controlling costs of not only dental care but also general medical care.</p>

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  50. Tooth Loss and Risk of Dementia in the Community: the Hisayama Study Reviewed

    Kenji Takeuchi, Tomoyuki Ohara, Michiko Furuta, Toru Takeshita, Yukie Shibata, Jun Hata, Daigo Yoshida, Yoshihisa Yamashita, Toshiharu Ninomiya

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   Vol. 65 ( 5 ) page: E95 - E100   2017.5

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    ObjectivesTo clarify the effect of tooth loss on development of all-cause dementia and its subtypes in an elderly Japanese population.
    DesignProspective cohort study.
    SettingThe Hisayama Study, Japan.
    ParticipantsCommunity-dwelling Japanese adults without dementia aged 60 and older (N=1,566) were followed for 5years (2007-2012).
    MeasurementsParticipants were classified into four categories according to baseline number of remaining teeth (20, 10-19, 1-9, 0). The risk estimates of the effect of tooth loss on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model.
    ResultsDuring follow-up, 180 (11.5%) subjects developed all-cause dementia; 127 (8.1%) had AD, and 42 (2.7%) had VaD. After adjusting for potential confounders, there was a tendency for the multivariable-adjusted hazard ratio of all-cause dementia to increase with decrease in number of remaining teeth (P for trend=.04). The risk of all-cause dementia was 1.62 times as great in subjects with 10 to 19 teeth, 1.81 times as great in those with one to nine teeth, and 1.63 times as great in those with no teeth as in those with 20 teeth or more. An inverse association was observed between number of remaining teeth and risk of AD (P for trend=.08), but no such association was observed with risk of VaD (P for trend=.20).
    ConclusionTooth loss is associated with an increased risk of all-cause dementia and AD in the Japanese population.

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  51. Association between posterior teeth occlusion and functional dependence among older adults in nursing homes in Japan Reviewed

    Kenji Takeuchi, Maya Izumi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Shinya Kageyama, Seijun Ganaha, Yoshihisa Yamashita

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 17 ( 4 ) page: 622 - 627   2017.4

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    AimTo examine whether posterior teeth occlusion is associated with functional dependence regardless of the number of natural teeth among Japanese nursing home residents.
    MethodsThe present cross-sectional study included 234 residents aged &gt;60years from eight nursing homes in Aso City, Japan. Functional dependence in basic activities of daily living was measured using the Barthel Index, and the primary outcome was independence for essential personal care (Barthel Index60points). Posterior teeth occlusion was assessed by a dentist using the total number of functional tooth units, depending on the number and location of the remaining natural and artificial teeth on implant-supported, fixed, and removable prostheses. Logistic regression models were used to assess univariate and multivariate associations between the total number of functional tooth units and independence for essential personal care. Models were sequentially adjusted for the number of natural teeth, demographic characteristics, socioeconomic status, health behaviors and comorbidities.
    ResultsIndependence for essential personal care was found in 14.1% of participants. Greater total numbers of functional tooth units were significantly associated with greater odds of independence for essential personal care (odds ratio 1.12; 95% confidence interval 1.01-1.24). The association remained significant after adjustment for the number of natural teeth and other possible confounders (odds ratio 1.14, 95% confidence interval 1.01-1.29).
    ConclusionsPosterior teeth occlusion was independently associated with functional dependence among nursing home older residents in Japan. The maintenance and restoration of posterior teeth occlusion might be preventive factors against late-life functional decline. Geriatr Gerontol Int 2017; 17: 622-627.

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  52. Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis Reviewed

    Shinya Kageyama, Toru Takeshita, Mikari Asakawa, Yukie Shibata, Kenji Takeuchi, Wataru Yamanaka, Yoshihisa Yamashita

    PLOS ONE   Vol. 12 ( 4 ) page: e0174782   2017.4

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    Increasing attention is being focused on evaluating the salivary microbiota as a promising method for monitoring oral health; however, its bacterial composition greatly differs from that of dental plaque microbiota, which is a dominant etiologic factor of oral diseases. This study evaluated the relative abundance of subgingival plaque-specific bacteria in the salivary microbiota and examined a relationship between the abundance and severity of periodontal condition in patients with periodontitis. Four samples (subgingival and supragingival plaques, saliva, and tongue coating) per each subject were collected from 14 patients with a broad range of severity of periodontitis before periodontal therapy. The bacterial composition was analyzed by 16S rRNA gene amplicon sequencing using Ion PGM. Of the 66 species-level operational taxonomic units (OTUs) representing the mean relative abundance of &gt;= 1% in any of the four niches, 12 OTUs corresponding to known periodontal pathogens, including Porphyromonas gingivalis, were characteristically predominant in the subgingival plaque and constituted 37.3 +/- 22.9% of the microbiota. The total relative abundance of these OTUs occupied only 1.6 +/- 1.2% of the salivary microbiota, but significantly correlated with the percentage of diseased sites (periodontal pocket depth &gt;= 4 mm; r = 0.78, P &lt; 0.001), in addition to the abundance of subgingival plaque microbiota (r = 0.61, P = 0.02). After periodontal therapy, the total relative abundance of these 12 OTUs was evaluated as well as before periodontal therapy and reductions of the abundance through periodontal therapy were strongly correlated in saliva and subgingival plaque (r = 0.81, P &lt; 0.001). Based on these results, salivary microbiota might be a promising target for the evaluation of subgingival plaque-derived bacteria representing the present condition of periodontal health.

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  53. Posterior teeth occlusion and dysphagia risk in older nursing home residents: a cross-sectional observational study Reviewed

    Y. Okabe, K. Takeuchi, M. Izumi, M. Furuta, T. Takeshita, Y. Shibata, S. Kageyama, S. Ganaha, Y. Yamashita

    JOURNAL OF ORAL REHABILITATION   Vol. 44 ( 2 ) page: 89 - 95   2017.2

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    The total number of natural teeth was related to swallowing function among older adults; however, limited information is available regarding the impact of occluding pairs of teeth on swallowing function. This study aimed to examine the association between posterior teeth occlusion and dysphagia risk in older nursing home residents. This cross-sectional study included 238 residents aged 60years from eight nursing homes in Aso City, Japan. Swallowing function was evaluated using the modified water swallowing test (MWST); the primary outcome was dysphagia risk (MWST score 3). Posterior teeth occlusion was assessed using number of functional tooth units (FTUs), determined based on number and location of the remaining natural and artificial teeth on implant-supported, fixed or removable prostheses. Univariate and multivariate logistic regression analyses were performed to examine the association between posterior teeth occlusion and dysphagia risk, adjusted for the covariates of number of natural teeth, demographic characteristics, comorbidities, physical function, body mass index and cognitive function. Of the 238 subjects, 44 (18&lt;bold&gt;&lt;/bold&gt;5%) were determined to be at risk of dysphagia based on the MWST scores. The odds ratio (OR) of dysphagia risk decreased in subjects with higher total FTUs [OR=0&lt;bold&gt;&lt;/bold&gt;92, 95% confidence interval (CI) 0&lt;bold&gt;&lt;/bold&gt;87-0&lt;bold&gt;&lt;/bold&gt;98]. After adjusting for covariates, this association remained significant (OR=0&lt;bold&gt;&lt;/bold&gt;90, 95% CI 0&lt;bold&gt;&lt;/bold&gt;84-0&lt;bold&gt;&lt;/bold&gt;97). Loss of posterior teeth occlusion was independently associated with dysphagia risk in older nursing home residents. Maintaining and restoring posterior teeth occlusion may be an effective measure to prevent dysphagia.

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  54. 歯科医療・口腔保健の2050年までの研究課題 Reviewed

    竹内 研時, 深井 穫博

    ヘルスサイエンス・ヘルスケア   Vol. 16 ( 2 ) page: 85 - 90   2016.12

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  55. Effects of oral care with tongue cleaning on coughing ability in geriatric care facilities: a randomised controlled trial Reviewed

    M. Izumi, K. Takeuchi, S. Ganaha, S. Akifusa, Y. Yamashita

    JOURNAL OF ORAL REHABILITATION   Vol. 43 ( 12 ) page: 953 - 959   2016.12

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    Methods for preventing aspiration pneumonia are needed soon in order to reduce mortality from aspiration pneumonia and promote the health of the elderly. The aim of this randomised controlled trial was to examine whether oral care with tongue cleaning improves coughing ability in elderly individuals living in geriatric care facilities. Participants comprised of 114 residents of 11 group homes and private nursing homes in Aso City in Kumamoto Prefecture. Participants were randomly assigned to either (i) a group that underwent routine oral care with tongue cleaning (intervention group; n=58) or (ii) a group that underwent routine oral care alone (control group; n=56). Coughing ability was evaluated by measuring peak expiratory flow (PEF) before and after 4weeks of intervention. Before the intervention, PEF did not differ significantly between the intervention group (165 +/- 111Ls(-1)) and control group (159 +/- 105Ls(-1); P=0658). However, on termination of the intervention, PEF was significantly higher in the intervention group (254 +/- 142Ls(-1)) than in the control group (190 +/- 120Ls(-1); P=0014). After the intervention, PEF had increased significantly in both groups; however, this increase was significantly greater in the intervention group (090 +/- 095Ls(-1)) than in the control group (031 +/- 099Ls(-1); P&lt;0001). Oral care with tongue cleaning led to increased PEF, suggesting improved coughing ability. Oral care incorporating tongue cleaning appears to be important for preventing aspiration pneumonia.

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  56. 地域住民における口腔の健康状態と生活習慣病の関連性の検討 久山町研究

    古田 美智子, 竹内 研時, 竹下 徹, 柴田 幸江, 二宮 利治, 清原 裕, 山下 喜久

    口腔衛生学会雑誌   Vol. 66 ( 5 ) page: 465 - 474   2016.10

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    健康寿命の延伸には生活習慣病の予防が必要である。口腔の健康状態の維持は生活習慣病の予防につながると考えられているが、その関係性の解明は十分とはいえない。そこで本研究では、口腔の健康状態と生活習慣病の関係を調べた。平成19年度久山町住民健診で歯科健診を受診した40〜79歳の2,523人を分析対象者とした。口腔の健康状態は、現在歯数、歯周ポケットの深さ、う蝕経験状態を評価した。生活習慣病については、糖尿病、高血圧、脂質異常症の有病状況を評価し、すべての疾患を有していない者を「生活習慣病がない者」とした。年齢を40〜59歳と60〜79歳に層別化し、目的変数に生活習慣病の有無、説明変数は口腔の健康状態を用いてロジスティック回帰分析を行った。生活習慣病がない者は40〜59歳で42.0%、60〜79歳は17.9%であった。ロジスティック回帰分析で年齢、性別、body mass index、喫煙、飲酒、運動習慣、職業の影響を調整した結果、40〜59歳では多数歯の保有、60〜79歳では歯周ポケットが浅いことは生活習慣病がないことと関連していた。本研究では、口腔の健康な者には生活習慣病のない者が多いことが示されたことから、口腔の健康状態を良好に保つことが生活習慣病の予防につながる可能性が示唆された。(著者抄録)

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  57. Swallowing function and nutritional status in Japanese elderly people receiving home-care services: A 1-year longitudinal study Reviewed

    Y. Okabe, M. Furuta, S. Akifusa, K. Takeuchi, M. Adachi, T. Kinoshita, T. Kikutani, S. Nakamura, Y. Yamashita

    JOURNAL OF NUTRITION HEALTH & AGING   Vol. 20 ( 7 ) page: 697 - 704   2016.7

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    Malnutrition is a serious health concern for frail elderly people. Poor oral function leading to insufficient food intake can contribute to the development of malnutrition. In the present study, we explored the longitudinal association of malnutrition with oral function, including oral health status and swallowing function, in elderly people receiving home nursing care.
    Prospective observational cohort study with 1-year follow-up.
    Two mid-sized cities in Fukuoka, Japan from November 2010 to March 2012.
    One hundred and ninety-seven individuals, aged aeyen 60 years, living at home and receiving homecare services because of physical disabilities, without malnutrition.
    Oral health status, swallowing function, taking modified-texture diets such as minced or pureed foods, nutritional status, cognitive function, and activities of daily living were assessed at baseline. The associations between malnutrition at 1-year follow-up and these related factors were analyzed using a logistic regression model.
    Swallowing disorders [risk ratio (RR): 5.21, 95% confidence interval (95% CI): 1.65-16.43] were associated with malnutrition. On the other hand, oral health status did not have a direct association with malnutrition.
    Swallowing disorders may be associated with the incidence of malnutrition in elderly people receiving home-care. The findings indicate that maintaining swallowing function may contribute to the prevention of malnutrition in frail elderly people.

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  58. Tooth loss and metabolic syndrome in middle-aged Japanese adults Reviewed

    Michiko Furuta, An Liu, Takashi Shinagawa, Kenji Takeuchi, Toru Takeshita, Yoshihiro Shimazaki, Yoshihisa Yamashita

    JOURNAL OF CLINICAL PERIODONTOLOGY   Vol. 43 ( 6 ) page: 482 - 491   2016.6

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    Aim: Metabolic syndrome is associated with periodontal disease and dental caries; however, little attention has been given to the association between metabolic syndrome and tooth loss, which is the endpoint of these two diseases. This study examined this association in middle-aged adults over a 5-year period.
    Methods: A retrospective study was performed in 2107 participants (1718 males and 389 females) aged 35-60 years who underwent annual dental check-ups, to evaluate tooth loss and metabolic components, including obesity, elevated triglycerides, blood pressure, fasting glucose, and reduced high-density lipoprotein. Logistic regression analysis was performed to evaluate the association between metabolic syndrome (&gt;= 3 components) at the baseline examination and tooth loss.
    Results: Over a 5-year period, 10.8% of the participants lost at least one tooth. Compared to those with no metabolic components, participants with &gt;= 3 components had an increased risk of tooth loss (odds ratio = 1.54; 95% confidence interval: 1.01-2.37), adjusting for age, gender, dental caries experience, attachment loss, oral hygiene status, number of teeth, tooth brushing frequency, smoking, and occupational status.
    Conclusions: Metabolic syndrome was associated with the incidence of tooth loss among middle-aged adults.

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  59. Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study Reviewed

    Toru Takeshita, Shinya Kageyama, Michiko Furuta, Hidenori Tsuboi, Kenji Takeuchi, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

    SCIENTIFIC REPORTS   Vol. 6   page: 22164   2016.2

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    This population-based study determined the salivary microbiota composition of 2,343 adult residents of Hisayama town, Japan, using 16S rRNA gene next-generation high-throughput sequencing. Of 550 identified species-level operational taxonomic units (OTUs), 72 were common, in &gt;= 75% of all individuals, as well as in &gt;= 75% of the individuals in the lowest quintile of phylogenetic diversity (PD). These "core" OTUs constituted 90.9 +/- 6.1% of each microbiome. The relative abundance profiles of 22 of the core OTUs with mean relative abundances &gt;= 1% were stratified into community type I and community type II by partitioning around medoids clustering. Multiple regression analysis revealed that a lower PD was associated with better conditions for oral health, including a lower plaque index, absence of decayed teeth, less gingival bleeding, shallower periodontal pockets and not smoking, and was also associated with tooth loss. By contrast, multiple Poisson regression analysis demonstrated that community type II, as characterized by a higher ratio of the nine dominant core OTUs, including Neisseria flavescens, was implicated in younger age, lower body mass index, fewer teeth with caries experience, and not smoking. Our large-scale data analyses reveal variation in the salivary microbiome among Japanese adults and oral health-related conditions associated with the salivary microbiome.

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  60. Dental Caries and Community Socioeconomic Status in Japanese and Chinese Children : An Ecological Study

    LIU An, FURUTA Michiko, TAKEUCHI Kenji, YAMASHITA Yoshihisa

    口腔衛生学会雑誌   Vol. 66 ( 1 ) page: 32 - 38   2016.1

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    Our aim was to compare the dental caries status between Japanese and Chinese children and to examine the association between the community socioeconomic status (SES) and dental caries. We made use of data collected in national surveys in Japan and China. Japanese children aged 5 and 12 years old had more filled teeth than Chinese children. As a result of this large number of filled teeth, Japanese 5-year-old children had fewer decayed teeth than Chinese children. Japanese 12-year-old children who lived in communities with a high SES had significantly fewer dental caries than those who lived in communities with a lower SES. Conversely, in China, dental caries was positively associated with the community SES. This suggests that the association between dental caries and the community SES differs among countries.

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  61. Association between Oral Health and Lifestyle-related Diseases in Community-dwelling People: The Hisayama Study

    FURUTA Michiko, TAKEUCHI Kenji, TAKESHITA Toru, SHIBATA Yukie, NINOMIYA Toshiharu, KIYOHARA Yutaka, YAMASHITA Yoshihisa

    JOURNAL OF DENTAL HEALTH   Vol. 66 ( 5 ) page: 465 - 474   2016

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    <p>It is important to prevent lifestyle-related diseases to extend healthy life expectancy. Although maintaining oral health is known to prevent lifestyle-related diseases, the association has not yet been elucidated. Here, we investigated the association between oral health and lifestyle-related diseases in a population of community-dwelling people.</p><p>We recruited 2,523 people, aged 40-79 years, from subjects who participated in the 2007 Hisayama study. Each subject received a dental examination. To rate the oral health status, the number of teeth, periodontal pocket depth, and experience of dental caries were assessed. To rate the lifestyle-related disease status, the presence of diabetes, hypertension, and dyslipidemia was assessed. The absence of any disease was defined as "no lifestyle-related disease." Subjects were stratified into two age groups (40-59 and 60-79 years). We performed logistic regression analysis with the no lifestyle-related disease condition as a dependent variable and the oral health status as the independent variable.</p><p>The percentage of subjects with no lifestyle-related disease was 42.0% in the 40-59-year-old group and 17.9% in the 60-79-year-old group. Logistic regression analysis showed that no lifestyle-related disease was associated with a greater number of teeth in the 40-59-year-old group and shallow pocket depth in the 60-79-year-old group, after adjusting for age, sex, body mass index, smoking, alcohol consumption, exercise, and occupational status.</p><p> Good oral health was associated with good general health, without lifestyle-related diseases. The results suggest that maintaining oral health may contribute to preventing lifestyle-related diseases.</p>

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  62. Association of periodontal status with liver abnormalities and metabolic syndrome Reviewed

    Aisyah Ahmad, Michiko Furuta, Takashi Shinagawa, Kenji Takeuchi, Toru Takeshita, Yoshihiro Shimazaki, Yoshihisa Yamashita

    JOURNAL OF ORAL SCIENCE   Vol. 57 ( 4 ) page: 335 - 343   2015.12

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    Although an association between periodontal status and liver abnormalities has been reported, it has not been described in relation to metabolic syndrome (MetS), which often coexists with non-alcoholic fatty liver disease. We examined the association of a combination of liver abnormality and MetS with periodontal condition in Japanese adults, based on the level of alcohol consumption. In 2008, 4,207 males aged 45.4 +/- 8.9 years and 1,270 females aged 45.9 +/- 9.7 years had annual workplace health check-ups at a company in Japan. Periodontal status was represented as periodontal pocket depth at the mesio-buccal and mid-buccal sites for all teeth. Alanine aminotransferase (ALT), and metabolic components were examined. Multiple linear regression analysis showed a significant association between deep pocket depth and the coexistence of elevated ALT and MetS in males with low alcohol consumption. Females showed no such relationship. In conclusion, the association between periodontal condition and the combination of elevated ALT and MetS was confirmed in males. That is, a clear association between liver abnormalities and periodontal condition was seen in male subjects with no or low alcohol consumption and MetS, providing new insights into the connection between liver function and periodontal health.

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  63. Posterior Teeth Occlusion Associated with Cognitive Function in Nursing Home Older Residents: A Cross-Sectional Observational Study Reviewed

    Kenji Takeuchi, Maya Izumi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Shinya Kageyama, Seijun Ganaha, Yoshihisa Yamashita

    PLOS ONE   Vol. 10 ( 10 ) page: e0141737   2015.10

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    Early detection and subsequent reduction of modifiable risk factors for cognitive decline is important for extending healthy life expectancy in the currently aging society. Although a recent increase in studies on the state or number of the teeth and cognitive function, few studies have focused on the association between posterior teeth occlusion necessary to maintain chewing function and cognitive function among older adults. This study examined the association between posterior teeth occlusion and cognitive function in nursing home older residents. In this cross-sectional study, 279 residents aged &gt;= 60 years from eight nursing homes in Aso City, Japan participated in cognitive function and dental status assessments and completed a comprehensive questionnaire survey in 2014. Cognitive function was measured using a Mini-Mental State Examination (MMSE). Posterior teeth occlusion was assessed using a total number of functional tooth units (total-FTUs), depending on the number and location of the remaining natural and artificial teeth on implant-supported, fixed, and removable prostheses. Linear regression models were used to assess univariate and multivariate associations between total-FTUs and MMSE scores. Models were sequentially adjusted for demographic characteristics, number of natural teeth, socioeconomic status, health behaviors, comorbidities, physical function, and nutritional status. Among the 200 residents included in our analysis, mean MMSE scores and total-FTUs were 11.0 +/- 8.6 and 9.3 +/- 4.6, respectively. Higher total-FTUs were significantly associated with higher MMSE scores after adjustment for demographics and teeth number (B = 0.48, 95% confidence interval [CI] = 0.22-0.74). The association remained significant even after adjustment for all covariates (B = 0.25, 95% CI = 0.01-0.49). The current findings demonstrated that loss of posterior teeth occlusion was independently associated with cognitive decline in nursing home older residents in Japan. Maintenance and restoration of posterior teeth occlusion may be a preventive factor against cognitive decline in aged populations.

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  64. Serum antibody to Porphyromonas gingivalis and periodontitis progression: the Hisayama Study Reviewed

    Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

    JOURNAL OF CLINICAL PERIODONTOLOGY   Vol. 42 ( 8 ) page: 719 - 725   2015.8

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    AimTo assess the effectiveness of serum titres of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in a community-dwelling adult population.
    Materials and MethodsThis 4-year follow-up cohort study included 183 Japanese individuals (75 men and 108 women) aged 40-49years. The clinical attachment level was measured at two sites on all teeth present at baseline and follow-up, and periodontitis progression was defined as progression in attachment loss of 3mm at 2 measurement sites. Serum titres of antibody to Porphyromonas gingivalis were evaluated at baseline and served as the primary predictor variable for periodontitis progression.
    ResultsPeriodontitis progression was found in 8.7% subjects. In a multivariate logistic regression model, higher titres of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titres of antibody to Porphyromonas gingivalis per 10 units: odds ratio, 1.66; 95% confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95% confidence interval, 1.20-14.27).
    ConclusionsElevated serum titres of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.

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  65. Chewing Xylitol Gum Improves Self-Rated and Objective Indicators of Oral Health Status under Conditions Interrupting Regular Oral Hygiene Reviewed

    Takafumi Hashiba, Kenji Takeuchi, Yoshihiro Shimazaki, Toru Takeshita, Yoshihisa Yamashita

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 235 ( 1 ) page: 39 - 46   2015.1

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    Chewing xylitol gum provides oral health benefits including inhibiting Streptococcus mutans plaque. It is thought to be especially effective in conditions where it is difficult to perform daily oral cleaning. Our study aim was to determine the effects of chewing xylitol gum on self-rated and objective oral health status under a condition interfering with oral hygiene maintenance. A randomized controlled intervention trial was conducted on 55 healthy &gt;= 20-year-old men recruited from the Japan Ground Self Defense Force who were undergoing field training. Participants were randomly assigned to a test group (chewing gum; n = 27) or a control group (no gum; n = 28) and the researchers were blinded to the group assignments. The Visual Analog Scale (VAS) scores of oral conditions subjectively evaluated oral health, and the stimulated salivary bacteria quantity objectively evaluated oral health 1 day before field training (baseline) and 4 days after the beginning of field training (follow-up). VAS scores of all three oral conditions significantly increased in the control group (malodor: p &lt; 0.001; discomfort: p &lt; 0.001; dryness: p &lt; 0.001), but only two VAS scores increased in the test group (malodor: p = 0.021; discomfort: p = 0.002). The number of salivary total bacteria significantly increased in the control group (p &lt; 0.01), while no significant change was observed in the test group (p = 0.668). Chewing xylitol gum positively affects self-rated and objective oral health status by controlling oral hygiene under conditions that interfere with oral hygiene maintenance.

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  66. Impact of Loss of Removable Dentures on Oral Health after the Great East Japan Earthquake: A Retrospective Cohort Study Reviewed

    Yukihiro Sato, Jun Aida, Kenji Takeuchi, Kanade Ito, Shihoko Koyama, Masako Kakizaki, Mari Sato, Ken Osaka, Ichiro Tsuji

    JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY   Vol. 24 ( 1 ) page: 32 - 36   2015.1

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    Purpose: The Great East Japan Earthquake in March 2011 destroyed many communities, and as a result many older victims lost their removable dentures. No previous studies have documented the prevalence of denture loss after a natural disaster or examined its negative impact. Therefore, investigation of the consequences of such a disaster on oral health is of major importance from a public health viewpoint.
    Materials and Methods: Three to five months after the disaster, questionnaire surveys were conducted in two coastal towns, Ogatu and Oshika, located in the area of Ishinomaki city, Miyagi prefecture. Among the survey participants, 715 individuals had used one or more removable dentures before the disaster, and these comprised the population analyzed. The effect of denture loss on oral health-related quality life (OHRQoL) was examined by a modified Poisson regression approach with adjustment for sex, age, subjective household economic status, dental caries, tooth mobility, psychological distress (K6), access to a dental clinic, physical activity, and town of residence.
    Results: There were 123 (17.2%) participants who had lost their dentures. In comparison with participants who had not lost their dentures, those lacking dentures showed a significantly higher relative risk for eating difficulties (RR = 2.65, 95% CI = 1.90-3.69), speech problems (RR = 4.37, 95% CI = 2.46-7.76), embarrassment upon smiling, laughing, or showing their teeth (RR = 5.32, 95% CI = 2.34-12.1), emotional distress (RR = 2.38, 95% CI = 1.41-4.03), and problems related to social interaction (RR = 6.97, 95% CI = 1.75-27.7).
    Conclusions: Denture loss appeared to impair eating and speaking ability, thus discouraging communication with others. Public health intervention after major natural disasters should include dental care.

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  67. Risk Factors for Reduced Salivary Flow Rate in a Japanese Population: The Hisayama Study Reviewed

    Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

    BIOMED RESEARCH INTERNATIONAL   Vol. 2015   page: 381821   2015

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    The purpose of this study was to determine distinct risk factors causing reduced salivary flow rate in a community-dwelling population using a prospective cohort study design. This was a 5-year follow-up survey of 1,377 community-dwelling Japanese individuals aged &gt;= 40 years. The salivary flow rate was evaluated at baseline and follow-up by collecting stimulated saliva. Data on demographic characteristics, use of medication, and general and oral health status were obtained at baseline. The relationship between reduced salivary flow rate during the follow-up period and its predictors was evaluated after adjustment for confounding factors. In a multivariate logistic regression model, higher age and plaque score and lower serum albumin levels were significantly associated with greater odds of an obvious reduction in salivary flow rate (age per decade, odds ratio [OR] - 1.25, 95% confidence interval [CI] - 1.03-1.51; serum albumin levels &lt;4 g/dL, OR - 1.60, 95% CI - 1.04-2.46; plaque score &gt;= 1, OR - 1.53, 95% CI - 1.04-2.24). In a multivariate linear regression model, age and plaque score remained independently associated with the increased rate of reduced salivary flow. These results suggest that aging and plaque score are important predictors of reduced salivary flow rate in Japanese adults.

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  68. Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers Reviewed

    Michiko Furuta, Yoshihiro Shimazaki, Shunichi Tanaka, Kenji Takeuchi, Yukie Shibata, Toru Takeshita, Fusanori Nishimura, Yoshihisa Yamashita

    BIOMED RESEARCH INTERNATIONAL   Vol. 2015   page: 897971   2015

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    It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer against Pg and inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 perpendicular to 11.2 years and 116 females with a mean age of 59.2 perpendicular to 10.3 years) were surveyed. Periodontal status, serumantibody titer against Pg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer against Pg and hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer against Pg, inflammatory markers, and periodontal disease. These findings suggest that immune response to Pg infection in addition to inflammatory components affects periodontal deterioration in females.

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  69. Nutritional status and dysphagia risk among community-dwelling frail older adults Reviewed

    K. Takeuchi, J. Aida, K. Ito, M. Furuta, Y. Yamashita, K. Osaka

    JOURNAL OF NUTRITION HEALTH & AGING   Vol. 18 ( 4 ) page: 352 - 357   2014.4

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    Although the presence of dysphagia is a key determinant of nutritional status among older adults, few studies have focused on the association between malnutrition and dysphagia risk in community-dwelling frail older adults. This study estimated the prevalence of malnutrition and quantified the association between malnutrition and dysphagia risk among community-dwelling older Japanese adults requiring long-term care.
    Cross-sectional study.
    This study was conducted with the cooperation of the Japan Dental Association and local dental associations in all 47 prefectures from January to February 2012.
    Individuals aged a parts per thousand yen65 years capable of oral nutrient intake who were living at home and receiving home dental care and treatment.
    Individual demographic characteristics and factors associated with health loss-related functional decline were obtained through interviews by home-visit dentists and self-administered questionnaires. Nutritional status and dysphagia risk were evaluated using the Mini Nutritional Assessment Short Form and the Dysphagia Risk Assessment for the Community-dwelling Elderly.
    Among 874 respondents (345 men and 529 women), 24.6% were malnourished, 67.4% were at risk of malnutrition, and 8.0% were well nourished. Dysphagia risk was related to an increased likelihood of malnutrition at an old age, even after adjusting for covariates (PR = 1.30, 95% CI = 1.01-1.67).
    Malnutrition is highly prevalent among community-dwelling frail older adults, and dysphagia risk is independently associated with malnutrition. Dysphagia may be an important predictor of malnutrition progression in aged populations.

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  70. Inequalities of dental prosthesis use under universal healthcare insurance Reviewed

    Yusuke Matsuyama, Jun Aida, Kenji Takeuchi, Georgios Tsakos, Richard G. Watt, Katsunori Kondo, Ken Osaka

    COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY   Vol. 42 ( 2 ) page: 122 - 128   2014.4

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    Background
    Social inequalities in oral health exist in various countries. In Japan, a country with universal healthcare insurance policy, people can receive medical and dental care and pay only 10-30% of the total cost of treatment. Additionally, very poor Japanese can receive care without any charge, by the benefit of public assistance. These policies are considered to affect oral health inequalities.
    Objectives
    This study examined the association between using a dental prosthesis and household income among older Japanese people.
    Methods
    Self-administered questionnaires were mailed to subjects as part of the Japan Gerontological Evaluation Study (JAGES) project in 2010. Of the 8576 people aged 65years or more living in Iwanuma, Japan, 5058 responded. We used 4001 respondents with no missing values. We stratified into two groups by having 20 teeth or not. Then, cross-tabulation, univariate logistic regression, and multivariate logistic regression were conducted for these two groups. The covariates are sex, age, education, and size of household.
    Results
    Of the all respondents included in the analyses, poorer respondents tended to have lower proportions with 20 or more teeth, and 54.6% respondents used dental prostheses. In the respondents with 19 or fewer teeth, higher-income group tended to show significantly higher dental prosthesis use. But the poorest income group showed high prevalence of dental prosthesis use as same as highest income group. Multiple logistic regression among respondents with 19 or fewer teeth showed that after adjustment for sex, age, education, and size of household, compared with the respondents with annual incomes of US$ &lt;5000, those with incomes of US$5000-9999 and US$10000-14999 had significantly lower odds ratios for using a dental prosthesis (OR=0.48 [95% CI=0.28-0.83], 0.56 [95% CI=0.33-0.95], respectively). The other respondents did not show significant differences.
    Conclusions
    Although universal healthcare insurance covered dental prostheses, a social gradient in dental prosthesis use was still observed. Low-income respondents tended to not use dental prosthesis, but the poorest respondents showed dental prosthesis utilization as high as the highest income group.

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  71. Association between Periodontitis and Stroke : A Meta-analysis Based on Periodontal Measurement Characteristics Reviewed

    MATSUYAMA Yusuke, AIDA Jun, TAKEUCHI Kenji, ITO Kanade, NAKAYASU Mieko, KOYAMA Shihoko, HASE Akihiro, TSUBOYA Toru, OSAKA Ken

    JOURNAL OF DENTAL HEALTH   Vol. 64 ( 1 ) page: 2 - 9   2014

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Oral Health  

    From the year 2000, an increasing number of reports have focused on the association between periodontal and cardiovascular diseases. Periodontal measurements are carried out in a number of ways, and, therefore, the grading of periodontitis in each study may differ according to the measurements used. Some previous studies included meta-analyses; however, the heterogeneity of periodontal measurements was not taken into account. Therefore, we divided periodontal measurements which are taken more frequently into two groups: Group A, which included measurements reflecting inflammation on examination, as indicated by Bleeding on Probing (BOP) and Probing Pocket Depth (PPD); and Group B, which included measurements not reflecting inflammation on examination, indicated by Clinical Attachment Loss (CAL), and analyzed the pooled odds ratios (OR) of each group. <br> We conducted online and manual searches, which revealed 688 articles, of which 11 fulfilled the inclusion criteria. The measurements in Group A did not reveal a significant correlation between periodontal and cerebrovascular diseases (OR = 1.35; 95% confidence interval [CI], 0.90-2.02), while Group B measurements revealed a significant positive correlation between the 2 diseases (OR = 1.96; 95% CI, 1.32-2.90). To assess the existence of publication bias, we drew funnel plots, which revealed the possibility of publication bias. In order to analyze non-published articles, a trim and fill method was used to assess Group B. After putative non-published articles were included in the analysis, a significant correlation was observed between periodontitis and cerebrovascular diseases (OR = 1.48; 95% CI, 1.07-2.06). <br> Differences were observed between periodontitis and cerebrovascular disease due to different periodontal measurements. BOP and PPD cannot indicate the duration of periodontal disease, while CAL is a cumulative measure that can indicate the duration of periodontitis. Therefore, a stronger association may exist between CAL and cerebrovascular disease than that of BOP or PPD. This study suggests that the association between periodontal disease and stroke may differ according to periodontal measurements. Therefore, careful analysis is required while investigating the association between periodontal and cerebrovascular diseases, and further studies are warranted.

    DOI: 10.5834/jdh.64.1_2

    CiNii Article

  72. Social Participation and Dental Health Status among Older Japanese Adults: A Population-Based Cross-Sectional Study Reviewed

    Kenji Takeuchi, Jun Aida, Katsunori Kondo, Ken Osaka

    PLOS ONE   Vol. 8 ( 4 ) page: e61741   2013.4

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    Background: Although social participation is a key determinant of health among older adults, few studies have focused on the association between social participation and dental health. This study examined the associations between social participation and dental health status in community-dwelling older Japanese adults.
    Methods and Findings: In 2010, self-administered postal questionnaires were distributed to all people aged &gt;= 65 years in Iwanuma City, Japan (response rate, 59.0%). Data from 3,517 respondents were analyzed. Data on the number of remaining natural teeth, for determining the dental health status, and social participation were obtained using self-administered questionnaires. The number, type, and frequency of social activities were used to assess social participation. Social activities were political organizations or associations, industrial or professional groups, volunteer groups, senior citizens' clubs, religious groups or associations, sports groups, neighborhood community associations, and hobby clubs. Using ordinal logistic regression, we calculated the odds ratios (OR) and 95% confidence intervals (95% CI) for an increase in category of remaining teeth based on the number, type, and frequency of social activities. Sex, age, marital status, current medical history, activity of daily living, educational attainment, and annual equivalent income were used as covariates. Of the respondents, 34.2% reported having &gt;= 20 teeth; 27.1%, 10-19 teeth; 26.3%, 1-9 teeth; and 12.4%, edentulousness. Social participation appeared to be related with an increased likelihood of having a greater number of teeth in old age, even after adjusting for covariates (OR = 1.30, 95% CI = 1.10-1.53). Participation in sports groups, neighborhood community associations, or hobby clubs was significantly associated with having more teeth.
    Conclusions: Our results suggest a protective effect of social participation on dental health. In particular, participation in sports groups, neighborhood community associations, or hobby clubs might be a strong predictor for retaining more teeth in later life.

    DOI: 10.1371/journal.pone.0061741

    Web of Science

    Scopus

    PubMed

    Other Link: http://orcid.org/0000-0001-8769-8955

  73. Community-level socioeconomic status and parental smoking in Japan Reviewed

    Kenji Takeuchi, Jun Aida, Manabu Morita, Yuichi Ando, Ken Osaka

    SOCIAL SCIENCE & MEDICINE   Vol. 75 ( 4 ) page: 747 - 751   2012.8

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    Community-level social environment has been considered to be associated with smoking behavior. However, no study has examined the association between community-level environmental factors and parental smoking behavior in families with young children. The aim of the present study was to examine the association between community-level socioeconomic status (SES) and parental smoking behavior. We used data from a cross-sectional study conducted from 2005 to 2006. We randomly selected 44 Japanese municipalities, 39 of which municipalities agreed to participate in this survey. The study subjects were participants in health check-ups for three-year-old children. Smoking status and individual demographic characteristics were obtained using self-administered questionnaires. Community-level variables were obtained from national census data for 2005. The prevalence of employment in tertiary industries and of unemployment was used to measure community-level SES. Multilevel Poisson regression models were used to calculate prevalence ratios (PRs) for smoking. Of 4143 subjects, a total of 3301 parents in 39 municipalities participated in our survey. Among the 2975 participants (71.8%) included in our analysis, 59.0% were smokers. There was no association between the job of the head of the household considered as an indicator of individual-level SES and smoking. By contrast, when we examined the relationship between prevalence of employment in tertiary industries as community-level SES and smoking, parents living in low middle SES municipalities had a significantly higher prevalence ratio for smoking, compared to parents living in the highest SES municipalities. This result suggested that those with lower community-level SES tended to have a higher prevalence of parental smoking regardless of individual-level SES. (C) 2012 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.socscimed.2012.04.001

    Web of Science

    Scopus

    PubMed

    Other Link: http://orcid.org/0000-0001-8769-8955

  74. Socioeconomic inequalities in tooth loss among Japanese

    Ito K.

    Interface Oral Health Science 2011     page: 291 - 293   2012.1

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    Publishing type:Research paper (scientific journal)   Publisher:Interface Oral Health Science 2011  

    DOI: 10.1007/978-4-431-54070-0_86

    Scopus

  75. Gender differences in the association between self-rated oral health and socioeconomic status among Japanese

    Wakaguri S.

    Interface Oral Health Science 2011     page: 294 - 296   2012.1

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    Publishing type:Research paper (scientific journal)   Publisher:Interface Oral Health Science 2011  

    DOI: 10.1007/978-4-431-54070-0_87

    Scopus

  76. 都道府県歯科保健条例の記載事項の比較

    竹内 研時, 相田 潤, 岩城 倫弘, 田口 千恵子, 田浦 勝彦, 小林 清吾, 小坂 健

    ヘルスサイエンス・ヘルスケア   Vol. 11 ( 2 ) page: 72 - 77   2011.12

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:深井保健科学研究所  

    2011年12月迄に、全国23道県で歯科保健条例が制定されている。各条例の特徴を調査し、記載事項を比較検討した。全ての条例で、健康の保持・増進、市町村との連携協力、歯科保健計画、障害者・要介護者への支援を記載していた。一方で、科学的根拠が存在し重要と考えられるフッ化物応用・洗口、喫煙対策、国と日本歯科医師会が主体となって進めている8020運動の記載がない条例が少なからず存在した。更に、口腔の健康格差是正にまで踏み込んで記載している条例は3県のみであった。今後条例を制定する地域においては、健康格差やフッ化物応用・洗口、喫煙対策といった項目も漏らさず記載する必要がある。

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Books 6

  1. 新編 衛生学・公衆衛生学

    安井利一他(編), 竹内研時他(著)( Role: Contributor)

    医歯薬出版社  2021.2 

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    Language:Japanese

  2. フロリデーション・ファクツ2018 科学的根拠に基づく水道水フロリデーション

    日本口腔衛生学会フッ化物応用委員(編), 小林清吾他(監), 竹内研時他(訳)( Role: Joint translator)

    口腔保健協会  2020.11 

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    Language:Japanese

  3. 健康長寿のための口腔保健と栄養をむすぶエビデンスブック

    深井穫博(編), 竹内研時他(著)( Role: Contributor)

    医歯薬出版  2019.8 

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    Language:Japanese

  4. 認知症の人への歯科治療ガイドライン

    日本老年歯科医学(編), 平野浩彦他(著), 竹内研時他(コンセンサスボード)

    医歯薬出版  2019.6 

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    Language:Japanese

  5. オーストラリアにおける水道水フロリデーション

    NPO法人日本フッ化物むし歯予防協会(編), 竹内研時他(訳)( Role: Joint translator)

    口腔保健協会  2019.2 

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  6. MNA在宅栄養ケア 在宅高齢者の低栄養予防と早期発見

    葛谷雅文他(編), 竹内研時他(著)( Role: Contributor)

    医歯薬出版  2015.1  ( ISBN:4263706374

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    Total pages:100   Language:Japanese

    ASIN

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MISC 60

  1. フレイル状態にある関節リウマチ患者と地域在住高齢者の比較検討

    上地 香杜, 小嶋 雅代, 安岡 実佳子, 武藤 剛, 飯塚 玄明, 斎藤 民, 渡邉 美貴, 鈴木 貞夫, 竹内 研時, 若井 建志, 尾島 俊之, 近藤 克則

    日本公衆衛生学会総会抄録集   Vol. 79回   page: 250 - 250   2020.10

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  2. 高齢者サロンへの参加状況と味覚・舌圧との関連

    永吉 真子, 玉井 慎美, 延末 謙一, 本多 由起子, 竹内 研時, 若井 建志, 前田 隆浩

    日本公衆衛生学会総会抄録集   Vol. 79回   page: 253 - 253   2020.10

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  3. 社会参加とフレイル 関節リウマチ患者と「健康とくらしの調査2016」参加者との比較

    小嶋 雅代, 上地 香杜, 安岡 実佳子, 武藤 剛, 飯塚 玄明, 斎藤 民, 渡邉 美貴, 鈴木 貞夫, 竹内 研時, 若井 建志, 尾島 俊之, 近藤 克則

    日本公衆衛生学会総会抄録集   Vol. 79回   page: 250 - 250   2020.10

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  4. 都道府県別にみた歯科医師の人口ピラミッドから見える歯科医師供給の将来像

    安藤 雄一, 福田 英輝, 田野 ルミ, 竹内 研時, 大島 克郎

    日本公衆衛生学会総会抄録集   Vol. 79回   page: 419 - 419   2020.10

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  5. 中学生のインターネット利用時間とう蝕経験の関連の検討

    藤田 美枝子, 野口 有紀, 森下 綾香, 松本 美奈子, 松浦 知佐子, 竹内 研時

    日本歯科衛生学会雑誌   Vol. 15 ( 1 ) page: 68 - 68   2020.8

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  6. 成人における主観的な口腔健康状態と自殺を考えた経験との関連

    野口 有紀, 藤田 美枝子, 竹内 研時

    日本歯科衛生学会雑誌   Vol. 15 ( 1 ) page: 34 - 44   2020.8

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    【目的】わが国の自殺死亡率は諸外国よりも高く、自殺予防策は重要な課題である。自殺はうつを背景としたものが多く、うつと口腔健康状態との関連性が報告されていることから、歯科から自殺予防支援ができる可能性がある。しかしながら、自殺と口腔状態に着目した報告はない。そこで、成人の自殺を考えた経験を把握する方法として、主観的な口腔健康状態が有用であるか検証することを本研究の目的とした。【対象および方法】2017年1〜2月に20〜69歳の者を無作為に1,500人抽出し、郵送法による無記名自己記入式質問調査を実施した。欠損値を除いた423人を対象に共分散構造分析を実施後、自殺を考えた経験の有無を目的変数、性別・最終教育歴・世帯収入・婚姻状態・喫煙・飲酒・主観的な全身健康状態・主観的な口腔健康状態・1日の歯磨き回数・歯間部補助用具の使用・定期的歯科健診・かかりつけ歯科医師の有無を説明変数とし、ロジスティック回帰分析を行った。【結果および考察】主観的な口腔健康状態のよくない者は26.5%、自殺を考えた経験がある者は21.5%であった。共分散構造分析では、主観的な口腔健康状態と自殺を考えた経験は同一の健康状態の因子を背景に持つことが確認された。ロジスティック回帰分析では、主観的な口腔健康状態のよくない者はよい者に比べて、自殺を考えた経験ありのオッズが2.50(95%CI:1.51-4.14)倍有意に高かった(p<0.05)。【結論】成人の自殺を考えた経験を把握する方法として、主観的な口腔健康状態が有用である可能性が示された。(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J04854&link_issn=&doc_id=20200831430003&doc_link_id=%2Fds1denhy%2F2020%2F001501%2F009%2F0034-0044%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fds1denhy%2F2020%2F001501%2F009%2F0034-0044%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  7. 壮年期における口腔健康状態と緑茶摂取との関連

    野口 有紀, 藤田 美枝子, 竹内 研時

    日本歯科衛生学会雑誌   Vol. 15 ( 1 ) page: 74 - 74   2020.8

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  8. 新型コロナウイルス感染拡大下における一般住民の歯科医院受診に関する意識調査

    高屋 翔, 小山 史穂子, 竹内 研時

    The Quintessence   Vol. 39 ( 7 ) page: 1588 - 1593   2020.7

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    Language:Japanese   Publisher:クインテッセンス出版(株)  

  9. COVID-19感染拡大下における歯科受診行動 どんな人が歯科受診に不安を抱いているのか

    小山 史穂子, 竹内 研時

    口腔衛生学会雑誌   Vol. 70 ( 3 ) page: 168 - 174   2020.7

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    COVID-19はパンデミックとなり、日本でも緊急事態宣言が発令された。歯科医療は治療の特性から、歯科医師と患者の交差感染リスクが高い可能性がある。本研究は、COVID-19感染拡大下の一般住民における歯科受診行動の実態を調査し、院内感染への懸念から、歯科受診に対して強い不安を抱いている者の特徴について検討することを目的とした。一般住民対象のWebアンケート調査を使用し、解析対象者は2020年5月1日〜10日に回答した1,885名(女性798名)とした。基本属性および5つの歯科受診に係わる項目について単純集計を行った。さらに、院内感染への懸念から、歯科受診に対して強い不安を抱くかと、性別、年齢、居住地域、これまでの歯科受診頻度との関連を、ポアソン回帰分析で検討しPrevalence ratio(PR)を算出した。緊急事態宣言後に、歯科医院に行く予定がない者を除いた688名の内、47.2%が予約の取り消しや変更などで歯科受診しなかった一方、52.8%は歯科受診していた。院内感染への懸念から、歯科受診に対して強い不安を抱いていると回答した者は454名(全体の24.1%)いた。多変量ポアソン回帰分析の結果、男性と比較し女性(PR=1.25、95%信頼区間=1.06;1.48)、これまでの歯科受診頻度が「年に数回」の者と比較し「困った時のみ通院」の者(PR=1.36、95%信頼区間=1.15;1.61)で歯科受診に対して強い不安を抱く割合が有意に高かった。本研究結果は今後のウィズ/ポストコロナ時代の歯科受診行動を考えるうえで貴重な資料となり得る。(著者抄録)

  10. 小学校でのフッ化物洗口の経験と成人のう蝕との関係

    古田 美智子, 竹内 研時, 竹下 徹, 須磨 紫乃, 影山 伸哉, 朝川 美加李, 奥 菜央理, 黒江 慧, 高尾 直宏, 柴田 幸江, 二宮 利治, 山下 喜久

    口腔衛生学会雑誌   Vol. 70 ( 2 ) page: 106 - 106   2020.4

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  11. メタボリックシンドロームの発症と現在歯数および摂食速度との関連

    須磨 紫乃, 古田 美智子, 竹内 研時, 山下 喜久

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 114 - 114   2020.3

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  12. 「生涯28」の科学的根拠について考える 歯の喪失の歯科・医科医療費への影響

    竹内 研時

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 68 - 68   2020.3

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  13. 「生涯28」の科学的根拠について考える 歯の喪失の歯科・医科医療費への影響

    竹内 研時

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 68 - 68   2020.3

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  14. 消化管がん患者の唾液マイクロバイオームに特徴的な細菌種の同定

    影山 伸哉, 竹下 徹, 竹内 研時, 朝川 美加李, 古田 美智子, 柴田 幸江, 山下 喜久, 永井 清志, 池部 正彦, 森田 勝, 益田 宗幸, 藤 也寸志, 清原 裕, 二宮 利治

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 149 - 149   2020.3

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  15. 成人における口腔の健康状態とインターネット活用による健康情報の入手との関連

    野口 有紀, 竹内 研時, 藁科 穂奈美, 藤田 美枝子, 仲井 雪絵

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 112 - 112   2020.3

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  16. 成人における口腔の健康状態とインターネット活用による健康情報の入手との関連

    野口 有紀, 竹内 研時, 藁科 穂奈美, 藤田 美枝子, 仲井 雪絵

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 112 - 112   2020.3

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  17. 地域住民の口腔の健康状態の経年的変化と歯科疾患実態調査との比較

    古田 美智子, 竹内 研時, 竹下 徹, 須磨 紫乃, 影山 伸哉, 朝川 美加李, 黒江 慧, 柴田 幸江, 嶋崎 義浩, 二宮 利治, 山下 喜久

    口腔衛生学会雑誌   Vol. 70 ( 増刊 ) page: 117 - 117   2020.3

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  18. 地域住民における歯の喪失と認知症発症との関連 久山町研究

    竹内 研時

    口腔衛生学会雑誌   Vol. 70 ( 1 ) page: 7 - 10   2020.1

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    地域在住の一般高齢住民を対象とした前向きコホートデータをもとに、歯の喪失が認知症発症に及ぼす影響を病型別に検討した。2007〜2008年に福岡県久山町の住民健診を受診した60歳以上の高齢男女1566名(男性691名、女性875名)を解析対象とした。追跡期間(中央値5.3年)中に180名が認知症を発症し、病型別ではアルツハイマー病(AD)が127名、血管性認知症が42名であった。全認知症発症の調整ハザード比は20歯以上群に比べて10〜19歯群1.62、1〜9歯群1.81、0歯群1.63と現在歯数の減少に伴い有意に増加した。病型別でみた場合、AD発症の調整ハザード比も現在歯数の減少に伴い増加する傾向にあった。一方、血管性認知症発症と現在歯数の減少との間には有意な関係は認められなかったものの、20歯以上群に比べて10〜19歯群の血管性認知症発症の調整ハザード比は3.19と有意に高いことが確認された。

  19. 歯科衛生士等による定期的なう蝕予防の情報提供が中学生の歯科保健行動に及ぼす効果の検討

    藤田 美枝子, 野口 有紀, 竹内 研時, 仲井 雪絵

    日本歯科衛生学会雑誌   Vol. 14 ( 1 ) page: 176 - 176   2019.8

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  20. 口腔健康状態と自殺願望との関連

    野口 有紀, 藁科 穂奈美, 竹内 研時, 仲井 雪絵

    日本歯科衛生学会雑誌   Vol. 14 ( 1 ) page: 161 - 161   2019.8

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  21. 歯周状態と肝機能の関連性について

    黒江 慧, 古田 美智子, 竹内 研時, 田中 照彦, 須磨 紫乃, 竹下 徹, 品川 隆, 山下 喜久

    口腔衛生学会雑誌   Vol. 69 ( 3 ) page: 154 - 154   2019.7

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  22. 歯周組織状態と糖尿病発症との関係

    古田 美智子, 竹内 研時, 竹下 徹, 須磨 紫乃, 品川 隆, 嶋崎 義浩, 山下 喜久

    口腔衛生学会雑誌   Vol. 69 ( 増刊 ) page: 163 - 163   2019.4

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  23. 歯周組織状態と非ウイルス性の肝線維化の関連性について

    黒江 慧, 古田 美智子, 竹内 研時, 田中 照彦, 須磨 紫乃, 竹下 徹, 嶋崎 義浩, 品川 隆, 山下 喜久

    口腔衛生学会雑誌   Vol. 69 ( 増刊 ) page: 164 - 164   2019.4

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  24. 地域高齢者における歯の損失と認知症の危険性 久山研究(Tooth Loss and Risk of Dementia in the Community: the Hisayama Study)

    竹内 研時

    口腔衛生学会雑誌   Vol. 69 ( 増刊 ) page: 60 - 60   2019.4

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  25. 地域歯科保健人材養成プログラムの概要と今後の在り方-口腔衛生学会専門医の創設を見据えて- 地域歯科保健を支える歯科医師・研究者に求められる知識・技能と課題(大学・研究者の立場から)

    竹内 研時

    口腔衛生学会雑誌   Vol. 69 ( 増刊 ) page: 83 - 84   2019.4

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  26. メタボリックシンドロームの発症と歯科健診受診との関連:5年間の後ろ向きコホート研究

    田中照彦, 竹内研時, 古田美智子, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

    口腔衛生学会雑誌   Vol. 68 ( 増刊 ) page: 111 - 111   2018.4

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  27. かかりつけ歯科医の性別による患者の歯科保健行動の違い

    竹内研時, 野口有紀, 山下喜久

    口腔衛生学会雑誌   Vol. 68 ( 増刊 ) page: 122 - 122   2018.4

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  28. 誤嚥性肺炎予防における舌清掃を加えた口腔ケアが咳嗽力の維持・改善に与える影響の検討

    泉 繭依, 竹内 研時, 秋房 住郎, 我那覇 生純, 山下 喜久

    日本口腔ケア学会雑誌   Vol. 12 ( 3 ) page: 162 - 162   2018.4

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  29. 施設入所高齢者における舌苔マイクロバイオームと肺炎死亡の関連

    影山 伸哉, 竹下 徹, 古田 美智子, 冨岡 未記子, 朝川 美加李, 須磨 紫乃, 竹内 研時, 柴田 幸江, 岩佐 康行, 山下 喜久

    日本口腔ケア学会雑誌   Vol. 12 ( 3 ) page: 162 - 162   2018.4

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  30. 施設高齢者における現在歯数に関連する因子の検討

    岩佐康行, 須磨紫乃, 古田美智子, 竹内研時, 山下喜久

    口腔衛生学会雑誌   Vol. 68 ( 増刊 ) page: 166 - 166   2018.4

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  31. 地域在住高齢者における咀嚼機能と低栄養の関連性の男女差の検討

    須磨紫乃, 古田美智子, 竹内研時, 竹下徹, 竹下徹, 柴田幸江, 嶋崎義浩, 二宮利治, 山下喜久

    口腔衛生学会雑誌   Vol. 68 ( 増刊 ) page: 163 - 163   2018.4

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  32. 舌苔細菌叢の構成と高齢者の肺炎死亡リスクとの関連

    竹下 徹, 影山 伸哉, 須磨 紫乃, 古田 美智子, 竹内 研時, 朝川 美加李, 岩佐 康行, 山下 喜久

    日本嫌気性菌感染症学会雑誌   Vol. 48 ( 1 ) page: 37 - 37   2018.3

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  33. 地域一般住民における呼吸機能低下に及ぼす歯周病の影響の解析 久山町研究

    福山 聡, 松元 幸一郎, 竹内 研時, 緒方 大聡, 竹下 徹, 古田 美智子, 須磨 紫乃, 秦 淳, 二宮 利治, 山下 喜久, 井上 博雅, 中西 洋一

    日本呼吸器学会誌   Vol. 7 ( 増刊 ) page: 255 - 255   2018.3

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  34. 地域一般住民における呼吸機能低下に及ぼす歯周病の影響の解析 久山町研究

    福山 聡, 松元 幸一郎, 竹内 研時, 緒方 大聡, 竹下 徹, 古田 美智子, 須磨 紫乃, 秦 淳, 二宮 利治, 山下 喜久, 井上 博雅, 中西 洋一

    日本呼吸器学会誌   Vol. 7 ( 増刊 ) page: 255 - 255   2018.3

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  35. 九州・沖縄地方における集団応用フッ化物洗口普及の推移(第2報) 県別の実施市町村の割合、施設別の実施状況と公的支援状況について

    田浦 勝彦, 晴佐久 悟, 古田 美智子, 竹内 研時, 井上 文子, 岩瀬 達雄, 重政 昭彦, 市野 浩司, 難波 亮二, 森木 大輔, 加藤 進作, 木本 一成, 筒井 昭仁, 境 脩, 山内 皓央

    口腔衛生学会雑誌   Vol. 68 ( 1 ) page: 45 - 46   2018.1

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  36. 「口腔保健の新定義」に関する動向

    深井 穫博, 佐々木 健, 野村 圭介, 大内 章嗣, 安藤 雄一, 小川 祐司, 岡田 寿郎, 嶋崎 義浩, 宮崎 秀夫, 竹内 研時

    口腔衛生学会雑誌   Vol. 67 ( 4 ) page: 306 - 310   2017.10

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  37. 農山村地域における地縁的な活動への参加と主観的健康感との関連

    野口 有紀, 伊藤 奏, 竹内 研時, 若林 チヒロ, 仲井 雪絵, 中野 恵美子, 有泉 祐吾, 尾島 俊之

    日本公衆衛生学会総会抄録集   Vol. 76回   page: 539 - 539   2017.10

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  38. 政策声明 認知症に対する口腔保健の予防的役割

    葭原 明弘, 安藤 雄一, 深井 穫博, 安細 敏弘, 伊藤 博夫, 佐々木 健, 山本 龍生, 皆川 久美子, 宮本 茜, 岩崎 正則, 竹内 研時, 日本口腔衛生学会, 日本口腔衛生学会疫学研究委員会および政策声明委員会

    口腔衛生学会雑誌   Vol. 67 ( 4 ) page: 251 - 259   2017.10

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    認知症に影響する口腔関連の要因には、歯周組織の慢性炎症状態、口腔への刺激および咀嚼運動による脳への刺激、口腔機能の低下による低栄養、長期間にわたるバランスの良い食事スタイル、生活習慣病および社会交流が挙げられる。これらのエビデンスとして国内外での多くの縦断または介入研究において、認知機能の低下・認知症の発症と口腔健康状態との間で有意な関連が報告されている。したがって、口腔保健は認知症予防に寄与する蓋然性が高いと考えられ、口腔保健に従事する関係者は、このことを念頭に置いて一次〜三次予防(口腔疾患の予防、早期発見・早期治療による歯の喪失の予防、喪失部位に対する補綴治療)を系統的に今後進めていく必要がある。また、口腔保健からのアプローチは他職種との連携を通して行われる必要がある。加えて、政策面においては高齢者における介護予防プログラムへの歯科保健の導入を一層促進すべきであり、研究面においては認知機能の低下・認知症の発症に及ぼす口腔保健の効果についてエビデンスをさらに積み重ね、認知症予防に向けた認知症施策の推進と評価に資する根拠と実践を図ることが必要である(図)。(著者抄録)

  39. 地域一般住民における呼吸機能低下に及ぼす歯周病の影響の検討

    竹内 研時, 古田 美智子, 須磨 紫乃, 秦 淳, 二宮 利治, 山下 喜久, 松元 幸一郎, 福山 聡, 緒方 大聡

    日本公衆衛生学会総会抄録集   Vol. 76回   page: 447 - 447   2017.10

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  40. 口腔の健康状態及び歯科保健サービスが歯科医療費及び医療費に与える影響に関する文献レビュー

    竹内研時, 佐藤遊洋, 須磨紫乃, 古田美智子, 岡部優花, 田中照彦, 小坂健, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 129   2017.4

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  41. メタボリックシンドロームの発症と歯周病および口腔保健行動との関連:5年間の後ろ向きコホート研究

    田中照彦, 竹内研時, 古田美智子, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 150   2017.4

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  42. 高齢者施設入所者における現在歯数が発熱に及ぼす影響

    岩佐康行, 須磨紫乃, 古田美智子, 竹内研時, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 141   2017.4

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  43. 福岡県12歳児のう蝕の有病状況と地域の社会経済状態との検討

    岡部優花, 竹内研時, 古田美智子, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 162   2017.4

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  44. 舌苔マイクロバイオームが高齢者の発熱に及ぼす影響

    影山伸哉, 竹下徹, 須磨紫乃, 古田美智子, 竹内研時, 朝川美加李, 岩佐康行, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 107   2017.4

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  45. 舌苔マイクロバイオームの細菌構成と口腔の健康状態の関連

    朝川美加李, 竹下徹, 影山伸哉, 古田美智子, 竹内研時, 須磨紫乃, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 107   2017.4

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  46. 要介護高齢者における義歯の装着と認知機能との関連

    須磨紫乃, 古田美智子, 竹内研時, 岩佐康行, 山下喜久

    口腔衛生学会雑誌   Vol. 67   page: 139   2017.4

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  47. 口腔が健康な日本人成人における唾液のマイクロバイオームの特徴(Characteristics of salivary microbiome in orally-healthy Japanese adults)

    竹下 徹, 影山 伸哉, 朝川 美加李, 古田 美智子, 竹内 研時, 二宮 利治, 山下 喜久

    日本細菌学雑誌   Vol. 72 ( 1 ) page: 58 - 58   2017.2

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  48. 要介護高齢者における義歯の装着が認知機能に及ぼす影響

    須磨紫乃, 古田美智子, 竹内研時, 冨岡未記子, 岩佐康行, 山下喜久

    口腔衛生学会雑誌   Vol. 67 ( 1 ) page: 44‐45   2017.1

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  49. 口腔清掃が困難な環境下におけるキシリトール配合ガム摂取が口腔環境へ与える影響

    朝川美加李, 竹内研時, 葉柴崇文, 竹下徹, 佐伯洋二, 山下喜久

    口腔衛生学会雑誌   Vol. 67 ( 1 ) page: 45   2017.1

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  50. 九州・沖縄地方における集団応用フッ化物洗口普及の推移―1990~2016年の県別比較の結果―

    晴佐久悟, 晴佐久悟, 古田美智子, 古田美智子, 竹内研時, 岩瀬達雄, 重政昭彦, 市野浩司, 森木大輔, 加藤進作, 難波亮二, 木本一成, 木本一成, 筒井昭仁, 田浦勝彦, 境脩

    口腔衛生学会雑誌   Vol. 67 ( 1 ) page: 41 - 42   2017.1

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  51. Association between Oral Health and Lifestyle-related Diseases in Community-dwelling People: The Hisayama Study

    古田美智子, 竹内研時, 竹下徹, 柴田幸江, 二宮利治, 清原裕, 山下喜久

    口腔衛生学会雑誌   Vol. 66 ( 5 ) page: 465‐474   2016.10

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    DOI: 10.5834/jdh.66.5_465

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  52. 地域高齢者における歯の喪失が認知症発症に及ぼす影響の検討:久山町研究

    竹内研時, 古田美智子, 山下喜久, 二宮利治

    日本公衆衛生学会総会抄録集   Vol. 75th   page: 271   2016.10

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  53. WHOの簡易禁煙介入プログラムと日本の歯科禁煙教育モデルの比較

    尾崎和歌子, 蓮田賀子, 埴岡隆, 原田有理子, 竹内研時, 小川祐司

    口腔衛生学会雑誌   Vol. 66 ( 2 ) page: 293   2016.4

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  54. 職業が歯の喪失に与える影響の性差―後ろ向きコホート研究―

    原田有理子, 竹内研時, 古田美智子, 山下喜久

    口腔衛生学会雑誌   Vol. 66 ( 2 ) page: 292   2016.4

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  55. 歯周組織状態とメタボリックシンドローム発症との関連性:5年間の後ろ向きコホート研究

    田中照彦, 古田美智子, 竹内研時, 竹下徹, 嶋崎義浩, 山下喜久

    口腔衛生学会雑誌   Vol. 66 ( 2 ) page: 268   2016.4

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  56. 嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証

    竹内研時, 古田美智子, 岡部優花, 秋房住郎, 足立宗久, 木下俊則, 菊谷武, 山下喜久

    口腔衛生学会雑誌   Vol. 66 ( 2 ) page: 271   2016.4

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  57. 義歯装着が嚥下機能の改善に及ぼす効果の検討

    岡部 優花, 古田 美智子, 竹内 研時, 木村 年秀, 後藤 拓朗, 中村 誠司, 山下 喜久

    口腔衛生学会雑誌   Vol. 66 ( 1 ) page: 58 - 58   2016.1

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  58. 歯の有無が口腔常在細菌叢に与える影響

    影山 伸哉, 竹内 研時, 泉 繭依, 我那覇 生純, 竹下 徹, 柴田 幸江, 古田 美智子, 山下 喜久

    口腔衛生学会雑誌   Vol. 66 ( 1 ) page: 53 - 53   2016.1

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  59. 生活機能の低下が口腔常在細菌叢に与える影響

    影山 伸哉, 竹内 研時, 泉 繭依, 我那覇 生純, 竹下 徹, 柴田 幸江, 古田 美智子, 山下 喜久

    口腔衛生学会雑誌   Vol. 65 ( 2 ) page: 195 - 195   2015.4

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  60. 在宅要介護高齢者における低栄養と口腔機能に関する縦断研究

    岡部 優花, 古田 美智子, 秋房 住郎, 足立 宗久, 木下 俊則, 菊谷 武, 竹内 研時, 中村 誠司, 山下 喜久

    口腔衛生学会雑誌   Vol. 65 ( 2 ) page: 181 - 181   2015.4

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▼display all

Presentations 112

  1. 口腔保健から考える認知症予防 Invited

    竹内研時

    第42回九州口腔衛生学会総会  2020.9.6 

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    Event date: 2020.9.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  2. 「生涯28」の科学的根拠について考える 歯の喪失の歯科・医科医療費への影響 Invited

    竹内研時

    第69回日本口腔衛生学会総会  2020.4.24 

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    Event date: 2020.4.24

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  3. Tooth loss and risk of dementia in the community: the Hisayama Study Invited

    竹内研時

    第68回日本口腔衛生学会総会  2019.5.24 

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    Event date: 2019.5.24

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  4. 地域歯科保健を支える歯科医師・研究者に求められる知識・技能と課題 Invited

    竹内研時

    第68回日本口腔衛生学会総会  2019.5.23 

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    Event date: 2019.5.23

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  5. Posterior Teeth Occlusion and Functional Dependence Among Japanese Older Adults.

    Takeuchi K, Izumi M, Furuta M, Takeshita T, Shibata Y, Kageyama S, Ganaha S, Yamashita Y.

    The 94th IADR General Session & Exhibition  2016.6.23 

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    Event date: 2016.6.23

    Language:English   Presentation type:Oral presentation (general)  

  6. ストレス対処行動とがん死亡リスクとの関係:J-MICC Study

    永吉真子, 塚本峰子, 久保陽子, 岡田理恵子, 田村高志, 菱田朝陽, 竹内研時, 若井建志

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1.27

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. 精神的健康度とストレス対処行動との関連

    塚本峰子, 久保陽子, 永吉真子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1.27

    Language:Japanese   Presentation type:Oral presentation (general)  

  8. PAPSS1遺伝子多型と空腹時血糖値との関連

    藤和太, 内藤真理子, 塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 永吉真子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志, 浜島信之

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1.27

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. 炭水化物・脂質摂取量と全死亡との関連:日本多施設共同コーホート研究(J-MICC  Study)

    田村高志, 門松由佳, 塚本峰子, 久保陽子, 岡田理恵子, 永吉真子, 菱田朝陽, 竹内研時, 若井建志, 日本多施設共同コーホート研究

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1.27

    Language:Japanese   Presentation type:Oral presentation (general)  

  10. 新型コロナウイルス感染症緊急事態宣言期間における在宅勤務と座位時間延長との関連

    竹内研時, 小山晃英, 玉田雄大, 田淵貴大

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1.27

    Language:Japanese   Presentation type:Oral presentation (general)  

  11. フレイル状態にある関節リウマチ患者と地域在住高齢者の比較検討

    上地 香杜, 小嶋 雅代, 安岡 実佳子, 武藤 剛, 飯塚 玄明, 斎藤 民, 渡邉 美貴, 鈴木 貞夫, 竹内 研時, 若井 建志, 尾島 俊之, 近藤 克則

    第79回日本公衆衛生学会総会  2020.10.20 

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    Event date: 2020.10.20

    Language:Japanese   Presentation type:Oral presentation (general)  

  12. 都道府県別にみた歯科医師の人口ピラミッドから見える歯科医師供給の将来像

    安藤 雄一, 福田 英輝, 田野 ルミ, 竹内 研時, 大島 克郎

    第79回日本公衆衛生学会総会  2020.10.20 

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    Event date: 2020.10.20

    Language:Japanese   Presentation type:Oral presentation (general)  

  13. 社会参加とフレイル 関節リウマチ患者と「健康とくらしの調査2016」参加者との比較

    小嶋 雅代, 上地 香杜, 安岡 実佳子, 武藤 剛, 飯塚 玄明, 斎藤 民, 渡邉 美貴, 鈴木 貞夫, 竹内 研時, 若井 建志, 尾島 俊之, 近藤 克則

    第79回日本公衆衛生学会総会  2020.10.20 

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    Event date: 2020.10.20

    Language:Japanese   Presentation type:Oral presentation (general)  

  14. 高齢者サロンへの参加状況と味覚・舌圧との関連

    永吉真子, 玉井慎美, 延末謙一, 本多由起子, 竹内研時, 若井建志, 前田隆浩.

    第79回日本公衆衛生学会総会  2020.10.20 

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    Event date: 2020.10.20

    Language:Japanese   Presentation type:Oral presentation (general)  

  15. 中学生のインターネット利用時間とう蝕経験の関連の検討

    藤田 美枝子, 野口 有紀, 森下 綾香, 松本 美奈子, 松浦 知佐子, 竹内 研時

    第15回日本歯科衛生学会  2020.9.19 

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    Event date: 2020.9.19

    Language:Japanese  

  16. 壮年期における口腔健康状態と緑茶摂取との関連

    野口 有紀, 藤田 美枝子, 竹内 研時

    第15回日本歯科衛生学会  2020.9.19 

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    Event date: 2020.9.19

    Language:Japanese  

  17. 緊急事態宣言下での歯科医院の状況と一般住民の受診行動 Invited

    竹内研時

    第18回深井保健科学研究所コロキウム  2020.8.30 

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    Event date: 2020.8.30

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  18. メタボリックシンドロームの発症と現在歯数および摂食速度との関連

    須磨 紫乃, 古田 美智子, 竹内 研時, 山下 喜久

    第69回日本口腔衛生学会総会  2020.4.24 

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    Event date: 2020.4.24

    Language:Japanese  

  19. 消化管がん患者の唾液マイクロバイオームに特徴的な細菌種の同定

    影山 伸哉, 竹下 徹, 竹内 研時, 朝川 美加李, 古田 美智子, 柴田 幸江, 山下 喜久, 永井 清志, 池部 正彦, 森田 勝, 益田 宗幸, 藤 也寸志, 清原 裕, 二宮 利治

    第69回日本口腔衛生学会総会  2020.4.24 

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    Event date: 2020.4.24

    Language:Japanese  

  20. 成人における口腔の健康状態とインターネット活用による健康情報の入手との関連

    野口 有紀, 竹内 研時, 藁科 穂奈美, 藤田 美枝子, 仲井 雪絵

    第69回日本口腔衛生学会総会  2020.4.24 

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    Event date: 2020.4.24

    Language:Japanese  

  21. 地域住民の口腔の健康状態の経年的変化と歯科疾患実態調査との比較

    古田 美智子, 竹内 研時, 竹下 徹, 須磨 紫乃, 影山 伸哉, 朝川 美加李, 黒江 慧, 柴田 幸江, 嶋崎 義浩, 二宮 利治, 山下 喜久

    第69回日本口腔衛生学会総会  2020.4.24 

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    Event date: 2020.4.24

    Language:Japanese  

  22. 飲酒頻度と受動喫煙曝露との関連:J-MICC横断研究

    竹内研時, 塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 内藤真理子, 若井建志

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  23. 血漿ホモシステイン濃度におけるMTHFR C677T 遺伝子多型と身体活動度の遺伝子環境交互作用

    菱田朝陽, 塚本峰子, 道下裕子, 鈴木康司, 長谷川幸治, 中杤昌弘, 田村高志, 門松由佳, 久保陽子, 竹内研時, 若井建志

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  24. カフェイン代謝酵素CYP1A2遺伝子多型、コーヒー摂取及び緑茶摂取と空腹時血糖値異常との関連

    銀光, 細井菜穂子, 内藤真理子, 塚本峰子, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 竹内研時, 若井建志, 浜島信之

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  25. 血漿ホモシステイン・葉酸・ビタミンB12値および推 定葉酸摂取量と高血圧症との関連

    田村高志, 門松由佳, 塚本峰子, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 菱田朝陽, 内藤真理子, 竹内研時, 若井建志

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  26. 喪失歯数、歯磨き回数と高血圧症、脂質異常症およ び糖尿病との関連

    塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 内藤真理子, 竹内研時, 若井建志

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  27. 企業規模と全がん罹患リスクとの関連:J-MICC研究 静岡地区.

    門松由佳, 塚本峰子, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 内藤真理子, 竹内研時, 若井建志

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  28. 出産歴のある成人女性での授乳経験とメタボリック症候群のリスクとの関連:日本多施設共同コー ホート研究.

    松永貴史, 門松由佳, 塚本峰子, 久保陽子, 田村高志, 岡田理恵子, 篠壁多恵, 川合紗世, 菱田朝陽, 内藤真理子, 竹内研時, 若井建志

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  29. 高齢者の低栄養に関する社会的要因について

    古田美智子, 木村年秀, 丸岡三沙, 竹内研時, 須磨紫乃, 岡田寿朗, 豊嶋健治, 山下喜久

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  30. 一人で/誰かと笑うかで要介護リスクは異なるか: JAGES縦断研究

    山口知香枝. 竹内研時, 玉田雄大, 白井こころ, 大平哲也, 斉藤雅茂, 近藤 克則.

    第30回日本疫学会学術総会  2020.2.21 

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    Event date: 2020.2.21

    Language:Japanese   Presentation type:Poster presentation  

  31. 小学校でのフッ化物洗口の経験と成人のう蝕との関係

    古田 美智子, 竹内 研時, 竹下 徹, 須磨 紫乃, 影山 伸哉, 朝川 美加李, 奥 菜央理, 黒江 慧, 高尾 直宏, 柴田 幸江, 二宮 利治, 山下 喜久

    第41回九州口腔衛生学会総会  2019.9.23 

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    Event date: 2019.9.23

    Language:Japanese   Presentation type:Poster presentation  

  32. 歯科衛生士等による定期的なう蝕予防の情報提供が中学生の歯科保健行動に及ぼす効果の検討

    藤田 美枝子, 野口 有紀, 竹内 研時, 仲井 雪絵

    第14回日本歯科衛生学会  2019.9.14 

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    Event date: 2019.9.14

    Language:Japanese   Presentation type:Poster presentation  

  33. 口腔健康状態と自殺願望との関連

    野口 有紀, 藁科 穂奈美, 竹内 研時, 仲井 雪絵

    第14回日本歯科衛生学会  2019.9.14 

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    Event date: 2019.9.14

    Language:Japanese   Presentation type:Poster presentation  

  34. 疫学研究から政策への架け橋 Invited

    竹内研時

    第18回深井保健科学研究所コロキウム  2019.8.4 

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    Event date: 2019.8.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  35. Association of Oral Microbiota with Digestive Tract Cancers.

    Kageyama S, Takeshita T, Asakawa M, Matsumi R, Takeuchi K, Nagai K, Morita M, Masuda M, Toh Y, Ninomiya T, Kiyohara Y, Yamashita Y.

    The 97th IADR General Session & Exhibition  2019.6.22 

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    Event date: 2019.6.22

    Language:English   Presentation type:Poster presentation  

  36. 飲酒頻度と受動喫煙曝露との関連:J-MICC横断研究

    竹内研時, 塚本峰子, 門松由佳, 久保陽子, 岡田理恵子, 篠壁多恵, 川合紗世, 田村高志, 菱田朝陽, 内藤真理子, 若井建志.

    第30回日本疫学会学術総会  2019.2.21 

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    Event date: 2019.2.21

    Language:Japanese   Presentation type:Poster presentation  

  37. 施設入所高齢者における義歯利用と肺炎発症の関連

    竹内研時, 泉繭依, 古田美智子, 竹下徹, 柴田 幸江, 影山 伸哉, 岡部優花, 秋房 住郎,我那覇生純, 山下喜久

    第29回日本疫学会学術総会  2019.2.1 

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    Event date: 2019.2.1

    Language:Japanese   Presentation type:Poster presentation  

  38. 久山町研究のこれまでの道のり ~口腔保健と全身の健康状態との関連~ Invited

    竹内研時

    第17回深井保健科学研究所コロキウム  2018.8.19 

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    Event date: 2018.8.19

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  39. Characterization of Oral Microbiota and Acetaldehyde Production.

    Takeuchi K, Yokoyama S, Shibata Y, Matsumi R, Kageyama S, Takeshita T, Yamashita Y.

    The 96th IADR General Session & Exhibition.  2018.6.28 

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    Event date: 2018.6.28

    Language:English   Presentation type:Poster presentation  

  40. Periodontal Status and Lung Function in Middle-Aged and Older Adults.

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomya T, Yamashita Y.

    The 96th IADR General Session & Exhibition.  2018.6.26 

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    Event date: 2018.6.26

    Language:English   Presentation type:Oral presentation (general)  

  41. Gender-Specific Association Between Periodontal Disease and Job Classification Among Employees.

    Harada Y, Takeuchi K, Furuta M, Tanaka S, Yamashita Y.

    The 94th IADR General Session & Exhibition  2016.6.24 

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    Event date: 2016.6.24

    Language:English   Presentation type:Poster presentation  

  42. 口腔ケアによる肺炎の抑制効果:メタアナリシスによる検討

    HASE AKIHIRO, AIDA JUN, TAKEUCHI KENJI, ITO SUSUMU, NAKAYASU MIEKO, KOYAMA SHIHOKO, NARITA NOBUAKI, TSUBOTANI TOORU, OSAKA KEN

    口腔衛生学会雑誌  2013.4.30 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  43. 口腔の健康状態及び歯科保健サービスが歯科医療費及び医療費に与える影響に関する文献レビュー

    竹内研時, 佐藤遊洋, 須磨紫乃, 古田美智子, 岡部優花, 田中照彦, 小坂健, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  44. 口腔が健康な日本人成人における唾液のマイクロバイオームの特徴(Characteristics of salivary microbiome in orally-healthy Japanese adults)

    竹下 徹, 影山 伸哉, 朝川 美加李, 古田 美智子, 竹内 研時, 二宮 利治, 山下 喜久

    日本細菌学雑誌  2017.2 

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    Language:English   Presentation type:Oral presentation (general)  

  45. 健康高齢者および在宅・施設入所要介護高齢者における口腔の健康状態

    古田 美智子, 秋房 住郎, 菊谷 武, 冨岡 未記子, 岩佐 康行, 竹内 研時, 竹下 徹, 柴田 幸恵, 嶋崎 義浩, 清原 裕, 山下 喜久

    口腔衛生学会雑誌  2014.10 

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  46. 仮設住宅居住者における心理的ストレスのリスク要因の検討

    KOYAMA SHIHOKO, AIDA JUN, TAKEUCHI KENJI, ITO SUSUMU, MASUNO KANAKO, KONDO KATSUNORI, OSAKA KEN

    J Epidemiol  2013.1.24 

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  47. 仮想評価法を用いた歯の健康に対する支払意思額と社会経済的地位との関連について

    ITO SUSUMU, AIDA JUN, WAKAGURI SHINTARO, NOGUCHI YUKI, TAKEUCHI KENJI, OSAKA KEN

    口腔衛生学会雑誌  2011.8.30 

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  48. 介護保険施設入所高齢者の栄養状態に関わる口腔機能と嚥下機能.

    竹内研時, 泉繭依, 古田美智子, 我那覇生純, 山下喜久

    第21回日本摂食嚥下リハビリテーション学会学術大会  2015.9.11 

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  49. 介護保険施設入所高齢者における噛み合わせと認知機能の関連

    竹内研時, 泉繭依, 古田美智子, 竹下徹, 柴田幸江, 影山伸哉, 我那覇生純, 山下喜久

    第26回日本疫学会学術総会  2016.1.23 

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  50. 介護保険の総合的政策評価ベンチマーク・システムの開発 4)マルチレベル分析・GIS(地理情報システム)を用いた分析 ソーシャルキャピタルと高齢者の残存歯数の関連;J‐AGESプロジェクト

    OSAKA KEN, YAMAMOTO TATSUO, AIDA JUN, TAKEUCHI KENJI

    介護保険の総合的政策評価ベンチマーク・システムの開発 平成23年度 総括・分担研究報告書  2012 

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  51. 九州・沖縄地方における集団応用フッ化物洗口普及の推移―1990~2016年の県別比較の結果―

    晴佐久悟, 晴佐久悟, 古田美智子, 古田美智子, 竹内研時, 岩瀬達雄, 重政昭彦, 市野浩司, 森木大輔, 加藤進作, 難波亮二, 木本一成, 木本一成, 筒井昭仁, 田浦勝彦, 境脩

    第38回九州口腔衛生学会総会  2016.9.4 

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  52. 九州・沖縄地方における集団応用フッ化物洗口普及の推移 第2報 県別の実施市町村の割合,施設別の実施状況と公的支援状況について

    田浦勝彦, 晴佐久悟, 古田美智子, 竹内研時, 井上文子, 岩瀬達雄, 重政昭彦, 市野浩司, 難波亮二, 森木大輔, 加藤進作, 木本一成, 筒井昭仁, 境脩, 山内皓央

    口腔衛生学会雑誌  2018.1.30 

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  53. メタボリックシンドロームの発症と歯周病および口腔保健行動との関連:5年間の後ろ向きコホート研究

    田中照彦, 竹内研時, 古田美智子, 須磨紫乃, 竹下徹, 嶋崎義浩, 品川隆, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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  54. 一般住民の訪問歯科診療に対する認知に関する研究

    SHIRAKAWA RIKIMARU, ITO KANADE, WAKAGURI SHINTARO, TAKEUCHI KENJI, AIDA JUN, OSAKA KEN

    老年歯科医学  2011.9.30 

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  55. マルチレベル分析による親の喫煙行動と社会環境に関する研究

    TAKEUCHI KENJI, AIDA JUN, MORITA MANABU, ANDO YUICHI, OSAKA KEN

    J Epidemiol  2010.1.9 

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  56. ソーシャルキャピタルと高齢者の残存歯数の関連;J‐AGESプロジェクト

    AIDA JUN, KONDO KATSUNORI, YAMAMOTO TATSUO, TAKEUCHI KENJI, OSAKA KEN

    J Epidemiol  2012.1.26 

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  57. コホートデータを用いた刺激唾液分泌量の減少に関わる要因の検討:久山町研究

    TAKEUCHI KENJI, FURUTA MICHIKO, TAKESHITA TOORU, SHIBATA YUKIE, SHIMAZAKI YOSHIHIRO, AKIFUSA SUMIO, YAMASHITA YOSHIHISA

    口腔衛生学会雑誌  2014.4.30 

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  58. お小遣いか世帯収入か?~仮想評価法を用いた歯の健康への支払意思額との関連~

    ITO SUSUMU, AIDA JUN, TAKEUCHI KENJI, OSAKA KEN

    日本公衆衛生学会総会抄録集  2011.10.15 

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  59. お口に関する市民アンケート調査を用いた福岡市における歯科節目健診の認知度に関わる要因の検討

    竹内 研時, 古田 美智子, 安永 愛, 出分 菜々衣, 山下 喜久

    口腔衛生学会雑誌  2014.10 

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  60. WHOの簡易禁煙介入プログラムと日本の歯科禁煙教育モデルの比較

    尾崎 和歌子, 蓮田 賀子, 埴岡 隆, 原田 有理子, 竹内 研時, 小川 祐司

    口腔衛生学会雑誌  2016.4 

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  61. WHO の簡易禁煙介入プログラムと日本の歯科禁煙教育モデルの比較.

    尾崎和歌子, 蓮田賀子, 埴岡 隆, 原田有理子, 竹内研時, 小川祐司

    第65回日本口腔衛生学会総会  2016.5.28 

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  62. 高齢者施設入所者における現在歯数が発熱に及ぼす影響

    岩佐康行, 須磨紫乃, 古田美智子, 竹内研時, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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  63. 高齢者の無歯顎の地域格差とソーシャルキャピタルの関連;JAGESプロジェクト

    AIDA JUN, KONDO KATSUNORI, YAMAMOTO TATSUO, TAKEUCHI KENJI, OSAKA KEN

    日本公衆衛生学会総会抄録集  2013.10.15 

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  64. 高等学校における新型インフルエンザ感染拡大時の対応の現状

    HASE AKIHIRO, TAKEUCHI KENJI, WAKAKURI SHINTARO, ITO SUSUMU, AIDA JUN, OSAKA KEN

    日本公衆衛生学会総会抄録集  2011.10.15 

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  65. 高齢者における社会参加と口腔の主観的健康度の関連

    TAKEUCHI KENJI, AIDA JUN, OSAKA KEN, KONDO KATSUNORI

    日本公衆衛生学会総会抄録集  2011.10.15 

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  66. 高齢者における社会参加と残存歯数の関連

    TAKEUCHI KENJI, AIDA JUN, OSAKA KEN, KONDO KATSUNORI

    口腔衛生学会雑誌  2011.8.30 

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  67. 震災による義歯喪失の実態とその影響について

    SATO YUYO, AIDA JUN, TAKEUCHI KENJI, WAKAKURI SHINTARO, HATTORI YOSHINORI, KOSEKI TAKEYOSHI, OSAKA KEN, SASAKI KEIICHI, TSUJI ICHIRO

    口腔衛生学会雑誌  2012.4.30 

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  68. 東日本大震災による歯科医院への通院の中断と再開とその関連要因

    SUENAGA RYUSUKE, AIDA JUN, TAKEUCHI KENJI, WAKAKURI SHINTARO, HATTORI YOSHINORI, KOSEKI TAKEYOSHI, OSAKA KEN, SASAKI KEIICHI, TSUJI ICHIRO

    口腔衛生学会雑誌  2012.4.30 

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  69. 東日本大震災による義歯喪失と口腔のQOLの関連

    SATO YUKIHIRO, AIDA JUN, TAKEUCHI KENJI, WAKAGURI SHINTARO, FUJI TAKESHI, HATTORI YOSHINORI, KOSEKI TAKEYOSHI, OSAKA KEN, SASAKI KEIICHI, TSUJI ICHIRO

    宮城県公衆衛生学会会誌  2013.3 

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  70. 歯周疾患検診受診率の推移とその地域差に関する検討

    矢田部尚子, 古田美智子, 竹内研時, 須磨紫乃, 渕田慎也, 山本龍生, 山下喜久

    口腔衛生学会雑誌  2018.1.30 

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  71. 歯周病と脳卒中の関連:測定指標の差異を考慮したメタアナリシス

    MATSUYAMA YUSUKE, AIDA JUN, TAKEUCHI KENJI, ITO SUSUMU, NAKAYASU MIEKO, KOYAMA SHIHOKO, HASE AKIHIRO, NARITA NOBUAKI, TSUBOTANI TOORU, OSAKA KEN

    口腔衛生学会雑誌  2013.4.30 

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  72. 歯周組織状態とメタボリックシンドローム発症との関連性 5年間の後ろ向きコホート研究

    田中 照彦, 古田 美智子, 竹内 研時, 竹下 徹, 嶋崎 義浩, 山下 喜久

    口腔衛生学会雑誌  2016.4 

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  73. 歯周組織状態とメタボリックシンドローム発症との関連性:5 年間の後ろ向きコホート研究

    田中照彦, 古田美智子, 竹内研時, 竹下 徹, 嶋崎義浩, 山下喜久

    第65回日本口腔衛生学会総会  2016.5.29 

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  74. 歯科医療関連職種と歯科医療機関の業務のあり方及び需給予測に関する研究 口腔保健における需要を考える:口腔衛生学会自由集会における討論

    ANDO YUICHI, OUCHI AKITSUGU, OYAMA ATSUSHI, TSUNEISHI MIDORI, JIN KOICHIRO, FUKAI KAKUHIRO, TAKIGUCHI TOORU, FURUKAWA KIYOKA, TAKEUCHI KENJI, KINOSHITA ATSUHIRO

    歯科医療関連職種と歯科医療機関の業務のあり方及び需給予測に関する研究 平成23年度 総括・分担研究報告書  2012 

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  75. 生活機能の低下が口腔常在細菌叢に与える影響

    影山 伸哉, 竹内 研時, 泉 繭依, 我那覇 生純, 竹下 徹, 柴田 幸江, 古田 美智子, 山下 喜久

    口腔衛生学会雑誌  2015.4 

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  76. 福岡県12歳児のう蝕の有病状況と地域の社会経済状態との検討

    岡部優花, 竹内研時, 古田美智子, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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  77. 義歯装着が嚥下機能に及ぼす効果について

    岡部優花, 古田美智子, 竹内研時, 木村 年秀, 後藤 拓朗, 山下 喜久

    第22回日本摂食嚥下リハビリテーション学会学術大会  2016.9.24 

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  78. 職業が歯の喪失に与える影響の性差 後ろ向きコホート研究

    原田 有理子, 竹内 研時, 古田 美智子, 山下 喜久

    口腔衛生学会雑誌  2016.4 

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  79. 職業が歯の喪失に与える影響の性差─後ろ向きコホート研究─

    原田有理子, 竹内研時, 古田美智子, 山下喜久

    第65回日本口腔衛生学会総会  2016.5.28 

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  80. 自己評価口腔の健康度にはお小遣いが関連するか~社会経済的地位指標としてのお小遣いの利用~

    ITO SUSUMU, AIDA JUN, WAKAGURI SHINTARO, TAKEUCHI KENJI, NOGUCHI YUKI, OSAKA KEN

    口腔衛生学会雑誌  2012.4.30 

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  81. 舌苔マイクロバイオームが高齢者の発熱に及ぼす影響

    影山伸哉, 竹下徹, 須磨紫乃, 古田美智子, 竹内研時, 朝川美加李, 岩佐康行, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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  82. 舌苔マイクロバイオームの細菌構成と口腔の健康状態の関連

    朝川美加李, 竹下徹, 影山伸哉, 古田美智子, 竹内研時, 須磨紫乃, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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  83. 血清中Porphyromonas gingivalisの抗体価および全身状態が歯周組織状態に及ぼす影響についてのコホート研究

    FURUTA MICHIKO, SHIMAZAKI YOSHIHIRO, TAKEUCHI KENJI, TANAKA SHUN'ICHI, YAMASHITA YOSHIHISA

    口腔衛生学会雑誌  2014.1.30 

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  84. 血清抗体価による歯周疾患重症化リスクの縦断的検証 久山町研究

    竹内 研時, 古田 美智子, 竹下 徹, 柴田 幸江, 嶋崎 義浩, 秋房 住郎, 山下 喜久

    口腔衛生学会雑誌  2015.4 

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  85. 要介護高齢者における義歯の装着が認知機能に及ぼす影響

    須磨紫乃, 古田美智子, 竹内研時, 冨岡未記子, 岩佐康行, 山下喜久

    第38回九州口腔衛生学会総会  2016.9.4 

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  86. 要介護高齢者における義歯の装着と認知機能との関連

    須磨紫乃, 古田美智子, 竹内研時, 岩佐康行, 山下喜久

    口腔衛生学会雑誌  2017.4.30 

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  87. 認知機能が嚥下機能を介して栄養状態に与える効果の検証

    竹内研時, 泉繭依, 古田美智子, 岡部優花, 我那覇生純, 山下喜久

    第22回日本摂食嚥下リハビリテーション学会学術大会  2016.9.23 

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  88. 農山村地域における地縁的な活動への参加と主観的健康感との関連

    野口有紀, 伊藤奏, 竹内研時, 若林チヒロ, 仲井雪絵, 中野恵美子, 有泉祐吾, 尾島俊之

    日本公衆衛生学会総会抄録集  2017.10.15 

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  89. 都道府県歯科保健条例の記載事項の比較

    TAKEUCHI KENJI, AIDA JUN, IWAKI MICHIHIRO, TAGUCHI CHIEKO, TAURA KATSUHIKO, KOBAYASHI SEIGO, OSAKA KEN

    ヘルスサイエンス・ヘルスケア  2011.12.15 

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  90. 思春期におけるフッ化物配合歯磨剤使用に関する意識調査

    NOGUCHI YUKI, WAKAGURI SHINTARO, TAKEUCHI KENJI, ITO SUSUMU, AIDA JUN, OSAKA KEN

    口腔衛生学会雑誌  2010.8.30 

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  91. 性・年齢階級別にみた歯科医師数の推移~医師・歯科医師・薬剤師調査を用いた分析~

    TAKEUCHI KENJI, ANDO YUICHI, OUCHI AKITSUGU, FURUKAWA KIYOKA, OSAKA KEN

    口腔衛生学会雑誌  2010.8.30 

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  92. 地域高齢者における歯の喪失が認知症発症に及ぼす影響の検討 久山町研究

    竹内 研時, 古田 美智子, 山下 喜久, 二宮 利治

    第75回日本公衆衛生学会総会  2016.10.27 

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  93. 地域一般住民における呼吸機能低下に及ぼす歯周病の影響の検討

    竹内研時, 古田美智子, 須磨紫乃, 秦淳, 二宮利治, 山下喜久

    日本公衆衛生学会総会抄録集  2017.10.15 

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  94. 在宅高齢者の栄養状態と誤嚥リスクの把握

    TAKEUCHI KENJI, AIDA JUN, ITO SUSUMU, KOYAMA SHIHOKO, YOSHINAKA SUSUMU, OSAKA KEN

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)  2012 

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  95. 在宅高齢者の生活環境,地域環境および介護予防プログラム・介護サービスと高齢者の健康に関する疫学研究 日本の高齢者における社会参加と残存歯数の関連

    OSAKA KEN, TAKEUCHI KENJI, KONDO KATSUNORI, AIDA JUN

    在宅高齢者の生活環境、地域環境および介護予防プログラム・介護サービスと高齢者の健康に関する疫学研究 平成24年度 総括・分担研究報告書  2013 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  96. 在宅要介護高齢者における低栄養と口腔機能に関する縦断研究

    岡部 優花, 古田 美智子, 秋房 住郎, 足立 宗久, 木下 俊則, 菊谷 武, 竹内 研時, 中村 誠司, 山下 喜久

    口腔衛生学会雑誌  2015.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  97. 在宅療養要介護高齢者の口腔機能と生活活動動作に関する縦断的検討

    古田 美智子, 秋房 住郎, 岡部 優花, 足立 宗久, 木下 俊則, 竹内 研時, 中村 誠司, 菊谷 武, 山下 喜久

    口腔衛生学会雑誌  2015.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  98. 在宅療養要介護高齢者における口腔機能と死亡に関するコホート研究

    古田 美智子, 竹内 研時, 岡部 優花, 菊谷 武, 山下 喜久

    老年歯科医学  2014.9 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  99. 在宅療養要介護者における口腔の健康状態と肺炎,発熱の関係について

    OKABE YUKA, FURUTA MICHIKO, TAKEUCHI KENJI, NAKAMURA SEIJI, YAMASHITA YOSHIHISA

    老年歯科医学  2014.9.30 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  100. 口腔保健とQOLの向上に関する総合的研究 口腔と全身疾患に関するシステマティックレビュー 2)口腔ケアによる肺炎の予防効果:メタアナリシスによる検討

    OSAKA KEN, HASE AKIHIRO, MATSUYAMA YUSUKE, AIDA JUN, TSUBOYA TOORU, TAKEUCHI KENJI, ITO SUSUMU, KOYAMA SHIHOKO, NAKAYASU MIEKO, NARITA NOBUAKI

    口腔保健とQOLの向上に関する総合的研究 平成24年度 総括・分担研究報告書  2013 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  101. 口腔保健とQOLの向上に関する総合的研究 高齢者の口腔と全身の健康に影響する要因に関する研究

    OSAKA KEN, TAKEUCHI KENJI, MATSUYAMA YUSUKE

    口腔保健とQOLの向上に関する総合的研究 平成22年度 研究報告書  2011 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  102. 口腔清掃が困難な環境下におけるキシリトール配合ガム摂取が口腔環境へ与える影響

    朝川美加李, 竹内研時, 葉柴崇文, 竹下徹, 佐伯洋二, 山下喜久

    第38回九州口腔衛生学会総会  2016.9.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  103. 嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証

    竹内研時, 古田美智子, 岡部優花, 秋房住郎, 足立宗久, 木下俊則, 菊谷 武, 山下喜久

    第65回日本口腔衛生学会総会  2016.5.29 

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    Language:English   Presentation type:Oral presentation (general)  

  104. 嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証

    竹内 研時, 古田 美智子, 岡部 優花, 秋房 住郎, 足立 宗久, 木下 俊則, 菊谷 武, 山下 喜久

    口腔衛生学会雑誌  2016.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  105. 在宅療養における医科歯科連携の実施状況と連携拡大に求められる事項の検討

    MATSUYAMA YUSUKE, WAKAKURI SHINTARO, ONO MIZUHO, TAKEUCHI KENJI, ITO SUSUMU, AIDA JUN, OSAKA KEN

    日本公衆衛生学会総会抄録集  2011.10.15 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  106. 在宅療養支援診療所の概況と医科歯科連携

    ONO MIZUHO, WAKAKURI SHINTARO, MATSUYAMA YUSUKE, TAKEUCHI KENJI, ITO SUSUMU, AIDA JUN, OSAKA KEN

    日本公衆衛生学会総会抄録集  2011.10.15 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  107. 在宅療養者における口腔内と栄養摂取状態との関連

    WAKAGURI SHINTARO, AIDA JUN, TAKEUCHI KENJI, ITO KANADE, NOGUCHI YUKI, OSAKA KEN

    老年歯科医学  2011.9.30 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  108. 口腔保健とQOLの向上に関する総合的研究 口腔と全身疾患に関するシステマティックレビュー 1)歯周病と脳卒中の関連:測定指標の差異を考慮したメタアナリシス

    OSAKA KEN, MATSUYAMA YUSUKE, HASE AKIHIRO, AIDA JUN, TSUBOYA TOORU, TAKEUCHI KENJI, ITO SUSUMU, KOYAMA SHIHOKO, NAKAYASU MIEKO, NARITA NOBUAKI

    口腔保健とQOLの向上に関する総合的研究 平成24年度 総括・分担研究報告書  2013 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  109. Social Participation and Dental Health Status among Older Japanese. International conference

    Takeuchi K, Aida J, Kondo K, Osaka K

    IADR General Session & Exhibition.  2013.3.21 

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    Language:English   Presentation type:Poster presentation  

  110. Posterior Teeth Occlusion and Functional Dependence Among Japanese Older Adults International conference

    Takeuchi K, Izumi M, Furuta M, Takeshita T, Shibata Y, Kageyama S, Ganaha S, Yamashita Y

    The 94th IADR General Session & Exhibition  2016.6.25 

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    Language:English   Presentation type:Oral presentation (general)  

  111. Gender Differences in the Association between Periodontal Condition and Socioeconomic Status in Japanese Employees. International conference

    Yuriko Harada, Kenji Takeuchi, Michiko Furuta, Shunichi Tanaka, Yoshihisa Yamashita

    The 63rd Annual Meeting of Japanese Association for Dental Research.  2015.10.30 

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    Language:English   Presentation type:Poster presentation  

  112. Gender-Specific Association Between Periodontal Disease and Job Classification Among Employees International conference

    Y. Harada, K. Takeuchi, M. Furuta, S. Tanaka, Y. Yamashita

    The 94th IADR General Session & Exhibition  2016.6.24 

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    Language:English   Presentation type:Oral presentation (general)  

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Other research activities 5

  1. 日本口腔衛生学会指導医

    2021.01

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    認定年月日:2021年1月1日(番号:75)

  2. 日本疫学会上級疫学専門家

    2020.04

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    認定年月日:2020年4月1日(番号:CSE 20-179)

  3. 口腔衛生学会若手の会世話人

    2016.07

  4. 若手の会(疫学の未来を語る若手の会)世話人

    2016.02

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    2020年4月以降は代表幹事(広報担当) https://jeaweb.jp/youth/index.html

  5. 日本口腔衛生学会認定医

    2015.03

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    認定年月日:2015年3月2日(番号:463)

KAKENHI (Grants-in-Aid for Scientific Research) 18

  1. 歯科口腔保健の推進に資するう蝕予防のための手法に関する研究

    Grant number:21A2020  2021.04 - 2022.03

    厚生労働科学研究費:厚生労働行政推進調査事業費補助金 

    相田 潤, 晴佐久悟, 濃野要, 竹内研時, 磯﨑篤則, 荒川浩久, 石塚洋一, 古田美智子, 松山祐輔, 廣瀬晃子

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    Authorship:Coinvestigator(s) 

    Grant amount:\1799000 ( Direct Cost: \1384000 、 Indirect Cost:\415000 )

  2. 関節リウマチ患者のSuccessful Agingに向けたフレイル予防対策の構築

    Grant number:20H03954  2020.04 - 2025.03

    文部科学省研究費:基盤研究(B) 

    竹内 研時

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    Authorship:Coinvestigator(s) 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

    循環器疾患をはじめとする全身疾患に対して口腔が与える影響が注目されてきている。口腔や全身の健康を規定するおもな要因として、遺伝的要因および社会的決定要因(社会経済状態や保健医療制度など、健康を規定する社会環境要因)が相互に関連しあって健康に影響を与えることが、近年の研究で明らかになりつつある。遺伝子と社会環境の相互作用の解明は重要な科学的課題である。しかし、先行研究では、これらの要因を同時に考慮した研究は少ない。そこで、本研究は遺伝子と社会的決定要因の両方向からのアプローチにより、口腔と循環器疾患の関連を明らかにすることを目的とする。

  3. 受動喫煙のバイオマーカーとしてのコチニンと幼児・学童のう蝕の関連についての研究

    Grant number:20K10293  2020.04 - 2023.03

    文部科学省研究費:基盤研究(C) 

    後藤 拓朗, 古田 美智子, 竹内 研時, 竹下 徹, 山下 喜久

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    Authorship:Coinvestigator(s) 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    前向きコホート研究によって、香川県K市1歳6か月児健診受診者125人(観察群)、福岡県小学1、6年生200人で唾液中のコチニン濃度を測定し、1年半および2年間でのう蝕発症との関係を調べる。また、香川県K市1歳6か月児健診受診者125人(介入群)で、保護者で喫煙している者がいる場合は禁煙指導を行い、1年半後の保護者の喫煙行動の変化を観察群と比較する。研究の概要を下記に示す。

  4. Elucidation of factors affecting oral microbiome development in early life stage

    Grant number:20H03901  2020.04 - 2023.03

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    Authorship:Coinvestigator(s) 

    Grant amount:\17810000

  5. 高齢者の口腔機能と施設入所・死亡との関係に関する地域疫学研究ー日常生活に環境と習慣(人と人とのつながり・発声頻度・咀嚼)は予後に影響を与えるかー

    Grant number:20-02-10  2020.04 - 2021.03

    公益財団法人8020推進財団  令和2年度8020公募研究課題 

    永吉真子, 竹内研時, 前田隆浩

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    Authorship:Coinvestigator(s) 

    Grant amount:\650000 ( Direct Cost: \643500 、 Indirect Cost:\6500 )

  6. 口腔の健康と全身の健康の関連の文献レビューと因果推論手法の提案

    Grant number:19FA1018  2019.08 - 2020.03

    厚生労働科学研究費:厚生労働科学研究費補助金(厚生科研費) 

    相田 潤, 竹内 研時, 大野 幸子, 山田 聡, 小坂 健

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    Authorship:Coinvestigator(s) 

    Grant amount:\4940000 ( Direct Cost: \4304000 、 Indirect Cost:\636000 )

  7. プレシジョンメディシンに向けた口腔と循環器疾患についての遺伝と社会要因の解明

    Grant number:19H03861  2019.04 - 2024.03

    文部科学省研究費:基盤研究(B) 

    小坂 健, 相田 潤, 竹内 研時, 小山 志穂子

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    Authorship:Coinvestigator(s) 

    Grant amount:\17160000 ( Direct Cost: \13200000 、 Indirect Cost:\3960000 )

    循環器疾患をはじめとする全身疾患に対して口腔が与える影響が注目されてきている。口腔や全身の健康を規定するおもな要因として、遺伝的要因および社会的決定要因(社会経済状態や保健医療制度など、健康を規定する社会環境要因)が相互に関連しあって健康に影響を与えることが、近年の研究で明らかになりつつある。遺伝子と社会環境の相互作用の解明は重要な科学的課題である。しかし、先行研究では、これらの要因を同時に考慮した研究は少ない。そこで、本研究は遺伝子と社会的決定要因の両方向からのアプローチにより、口腔と循環器疾患の関連を明らかにすることを目的とする。

  8. Clarification of the relationship between periodontitis severity and the onset and progression of chronic obstructive pulmonary disease

    Grant number:19K10446  2019.04 - 2022.03

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  9. 歯の喪失予防と義歯利用が高齢者の笑って暮らせる生活の維持に果たす役割の検討

    Grant number:19-2-06  2019.04 - 2020.03

    公益財団法人8020推進財団  令和元年度8020公募研究課題 

    竹内研時, 近藤克則

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    Authorship:Principal investigator 

    Grant amount:\650000 ( Direct Cost: \643500 、 Indirect Cost:\6500 )

  10. Oral health and male-female health-survival paradox

    Grant number:18K09882  2018.04 - 2021.03

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    Authorship:Coinvestigator(s) 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

  11. Identification of oral health-related risk factors for development of dementia

    Grant number:17K17375  2017.04 - 2019.03

    Takeuchi Kenji

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    This study clarified oral-related risk factors contributing to the onset and progression of dementia in a community-dwelling adults aged 65 years or over in Hisayama town, adjusting for potential confounders. Salivary oxidative stress markers in Alzheimer's disease patients were significantly lower than those in healthy controls. In linear regression models, tooth loss was significantly positively associated with global brain atrophy, but not hippocampal atrophy, one of the morphological features of Alzheimer's disease.

  12. 費用対効果の高い歯科保健サービスの提供方法・内容の分析

    Grant number:H28-特別-指定-033  2016.11 - 2017.03

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    Authorship:Coinvestigator(s) 

    Grant amount:\2400000 ( Direct Cost: \2400000 )

  13. コホート・生体試料支援プラットフォーム

    Grant number:16H06277  2016.04 - 2025.03

    文部科学省研究費:新学術領域研究 

    竹内 研時

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    Authorship:Coinvestigator(s) 

    Grant amount:\2276040000 ( Direct Cost: \1750800000 、 Indirect Cost:\525240000 )

  14. A large-scale survey of tongue microbiota of elderly adults for the development of its maintenance approach

    Grant number:16H05557  2016.04 - 2019.03

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    Authorship:Coinvestigator(s) 

    Grant amount:\17420000

    Tongue microbiota is a primary source of microbial populations that are ingested with saliva. Therefore, careful attention is needed for the health maintenance in elderly adults, because they are susceptible to aspiration of oral contents. This study determined the microbial composition of elderly adults based on a comprehensive microbial community analysis using microbial DNA with a large sample size. We revealed variations in the tongue microbiota composition among community elderly adults, as well as a dysbiotic pattern associated with pneumonia-related death in the frail elderly adults. Our results would be a basis for the development a novel health maintenance approach of elderly adults targeting their tongue microbiota.

  15. Elucidation of the actual situation and the risk factor of the human papilloma virus infection involved in the oral cavity, pharynx cancer

    Grant number:15K20644  2015.04 - 2017.03

    Takeuchi Kenji

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    This study estimated the prevalence of high-risk human papillomavirus (HPV) infection and determined distinct risk factors for high-risk HPV infection in a community-dwelling adults aged 40-69 years. Among 574 respondents (269 men and 305 women), high-risk HPV infection was found in 25 respondents (4.4%). In a multivariate logistic regression model, higher plaque score was significantly associated with greater odds of high-risk HPV infection (plaque score >1, odds rario = 3.49, 95% confidence interval= 1.24-9.81). These findings suggest that plaque score is an important predictor of high-risk HPV infection and maintenance of oral hygiene may contribute to prevention of oral cavity, pharynx cancer in Japanese adults.

  16. Research for relationship between oral microboiome and head and neck and digestive organ cancers

    Grant number:15K15774  2015.04 - 2017.03

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    Authorship:Coinvestigator(s) 

    Grant amount:\3510000

    The purpose of this study is the characterization of the oral microbiome related to head and neck, digestive organ cancer. Saliva was collected from the patients who had a diagnosis of head and neck cancer or a digestive organ cancer in National Hospital Organization Kyushu Cancer Center. Salivary microbiome was analyzed with the next-generation sequencer. The results were compared with those of the salivary microbiome of dwelling population at Hisayama town to aim the identification of a special microbe or the unique constitution pattern to cancer patients. As a result, the salivary microbiome constitution peculiar to the patients of head and neck, digestive organ cancer was not recognized, but the constituent ratio of some bacterial species was significantly different between a cancer patients and non-cancer dwelling population.

  17. Serum antibody to Porphyromonas gingivalis and periodontitis progression: a prospective cohort study

    Grant number:25893177  2013.08 - 2015.03

    TAKEUCHI KENJI

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    Authorship:Principal investigator 

    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    This prospective cohort study assessed the effectiveness of serum titers of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in 183 Japanese individuals (75 men and 108 women) aged 40-49 years. Periodontitis progression, defined as a progression in attachment loss of 3 mm or greater at 2 or more measurement sites during the 4-year follow-up period, was found in 8.7% subjects. In a multivariate logistic regression model, higher titers of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titers of antibody to Porphyromonas gingivalis per 10 units: odds Ratio, 1.66; 95% confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95% confidence interval, 1.20-14.27). These findings suggest that elevated serum titers of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.

  18. The effect of local community cooperation on prevention of dental caries in children by Sociometry analysis

    Grant number:25463250  2013.04 - 2017.03

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    Authorship:Coinvestigator(s) 

    Grant amount:\4940000

    This study examined the effect of community characteristics and community health program on dental caries in children, considering health behavior as individual characteristics.
    The data of medical and dental examination for one and half years old and three years old was used. We explored the factor of increasing dental caries in children with and without dental caries, aged one and half years. This study indicates that fluoride application as community health program is more likely to prevent dental caries in children without dental caries than those who have dental caries.

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Teaching Experience (On-campus) 7

  1. Practice of Social Medicine

    2021

  2. Epidemiology and Preventive Medicine

    2021

  3. Young Leaders' Program

    2020

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    Intervention, randomization; Screening

  4. Epidemiology and Preventive Medicine

    2020

  5. Young Leaders' Program

    2019

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    Intervention, randomization; Epidemiology of cancer; Screening

  6. Practice of Social Medicine

    2019

  7. Epidemiology and Preventive Medicine

    2019

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Social Contribution 8

  1. 地域保健活動における統計・疫学の基礎と実践

    Lecturer

    愛知県健康医務部健康対策課歯科・栄養グループ  令和2年度 第1回 愛知県歯科衛生士人材育成研修  2020.12.18

  2. 地域歯科保健活動における統計・疫学の基礎知識

    Lecturer

    愛知県歯科医師会  令和2年度 医療圏代表者会議 研修会  2020.11.9

  3. 日本口腔衛生学会・COVID-19対策緊急アンケート結果速報

    Informant

    日本口腔衛生学会 新型コロナウイルス感染症(COVID-19)対策検討作業部会  2020.5.19

  4. 地域保健活動における統計・疫学の基礎知識

    Lecturer

    愛知県健康医務部健康対策課歯科・栄養グループ  令和元年度 第2回 愛知県歯科保健課題対応研修  2019.11.6

  5. 知って得する!健口情報

    Lecturer

    保健福祉局 健康医療部 口腔保健支援センター  平成30年度 生活習慣病予防月間 歯科講演会  2019.2.14

  6. 委員会報告: 「口腔保健の新定義」に関する動向

    Informant

    日本口腔衛生学会  2017.10.30

  7. 政策声明: 認知症に対する口腔保健の予防的役割

    Informant

    Japanese Society for Oral health  2017.5.31

  8. お口の健康と全身の健康の関係

    Lecturer

    福岡県保健医療介護部健康増進課健康づくり係  平成28年度 特定保健指導従事者研修会  2017.1.26

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Media Coverage 13

  1. 特別企画 日本口腔衛生学会 学会声明『生涯28』の科学的根拠について考える Newspaper, magazine

    歯界展望 2021年4月号(137巻4号)  2021.3.26

  2. with コロナの口腔予防管理 Newspaper, magazine

    歯界展望 2021年3月号(137巻3号)  2021.2.26

  3. 笑って減らそう要介護リスク 笑わない人は毎日笑う人の1・4倍も危険/運動より簡単 誰でもできる! Newspaper, magazine

    週刊朝日 2020年11月13日号  2020.11.4

  4. もっと笑いたい 発声で心身リラックス Newspaper, magazine

    毎日新聞 人生100年クラブ  2020.10.11

  5. 本当だった?「笑う門には福来たる」 介護リスクへの影響、名古屋大が初の大規模調査 Newspaper, magazine

    毎日新聞  2020.9.13

  6. 笑わない人ほど要介護リスク高く よく笑う人の1.4倍 Newspaper, magazine

    朝日新聞  2020.8.4

  7. 笑わない高齢者 介護必要になるリスク1.4倍に 名古屋大など TV or radio program

    NHK  おはよう日本  2020.7.16

  8. 新型コロナウイルス感染拡大下における一般住民の歯科医院受診に関する意識調査 Newspaper, magazine

    ザ・クインテッセンス 2020年7月号  2020.6.17

  9. 病気になる社会的要因を探る Newspaper, magazine

    朝日新聞 先端人  2020.4.19

  10. 歯周病でCOPDリスク3・5倍 喫煙しなくても危険 Newspaper, magazine

    朝日新聞  2019.4.10

  11. 肺の健康を守るには口の健康から。歯周病が呼吸機能低下を引き起こす。 Newspaper, magazine

    Dentalism 2018 Winter Vol. 33 Dentalism News & Topics  2018.12.1

  12. 非喫煙でも「たばこ病」に 歯周病でリスク上昇 Newspaper, magazine

    朝日新聞  2018.11.6

  13. 医局紹介:研究プロジェクトの精鋭たち 医局のエース紹介 Newspaper, magazine

    ザ・クインテッセンス 2018年5月号  2018.5.10

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