記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Internal Medicine  

Objective To explore the opinions of outpatients concerning a new communication method: the selfmanagement of assessed personal problems in health information records (SAPPHIRE) using patients' mobile phones to store and share medical content (medical SAPPHIRE, or m-SAPPHIRE). Methods A cross-sectional questionnaire survey. Patients Outpatients who visited us from March 1 to May 30, 2012, were asked to complete a questionnaire survey regarding SAPPHIRE and m-SAPPHIRE. The m-SAPPHIRE data consisted of a problem list, height, weight, waist size and active medication list. Ten questions were asked regarding the usefulness of m- SAPPHIRE, the sharing of m-SAPPHIRE and the use of mobile phones to store m-SAPPHIRE data. Results One hundred and ninety-three patients (male/female, 79/114; mean age, 57±21 years) were registered: 95.9% answered that m-SAPPHIRE would be useful, 98% agreed to manage their personal health records by themselves, and 95.8%, 93.8%, and 92.8% of the patients responded that they would allow m- SAPPHIRE information to be shared with family members, medical workers, and health care providers, respectively. Of the patients, 75.1% responded that they owned a mobile phone, and 43.5% answered that they could enter m-SAPPHIRE information into a mobile phone by themselves, while 27.5% responded that they could do so with someone's help. Conclusion Patients believe that m-SAPPHIRE would be useful for retrieving their health records during emergency situations or for sharing with family members and medical and health care providers. SAPPHIRE using mobile phones could be an inexpensive and legal method for sharing medical data. © 2013 The Japanese Society of Internal Medicine.

DOI： 10.2169/internalmedicine.52.9030

Scopus

PubMed

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Granulocytes: Production, Types and Roles in Disease  

Scopus

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Pediatric Blood and Cancer  

Background: Recent advances in multidisciplinary treatment approaches have improved the overall prognosis of pediatric brain tumors, but some patients remain refractory to treatment and do poorly. Several molecularly targeted therapies are under development for the treatment of brain tumors, and high-grade gliomas in adults are a particular area of study. Procedure: To better understand if these new therapies can be used in pediatric populations, we examined the expression of the following seven marker genes involved in signaling pathways targeted by new therapies: β-catenin, suppressor of fused (SUFU), erythroblastic leukemia viral oncogene homolog (ERBB) 2, platelet-derived growth factor receptorα (PDGFRα), proliferating cell nuclear antigen (PCNA), secreted protein acid and rich in cysteine (SPARC), and granulocyte colony-stimulating factor receptor (G-CSFR). Samples from 27 patients with the primitive neuroectodermal tumor (PNET)/medulloblastomas (MBs) (n=8), ependymomas (n=5), or gliomas (n=14) were assessed by quantitative real-time PCR. [Correction made here after initial online publication]. We assigned an EXP score to compare across samples and determined the levels of gene expression among tumor cell types. Results: Gene expression varied among the different tumors, but, within a tumor type, clear expression patterns were seen. The expression of SUFU, ERBB2, and PCNA in metastatic MBs were greater than that seen in non-metastatic MBs. Most glioma cases highly expressed PDGFRα and G-CSFR. Additionally, the expression patterns of gliomas and ependymomas were similar (r=0.77, P=0.04), but PNET/MBs substantially differed from gliomas (r=-0.37, P=0.41) or ependymomas (r=0.23, P=0.62). Conclusions: The development of new drugs targeting up-regulated pathways may be useful for the treatment of pediatric brain tumors. As new drugs are developed, gliomas and ependymomas may be treated with similar compounds. © 2011 Wiley Periodicals, Inc.

DOI： 10.1002/pbc.23009

Web of Science

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PubMed

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Basophil Granulocytes  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：公益社団法人 日本人間ドック学会  

<b>目的：</b>人間ドックにおいて高カルシウム（Ca）血症を呈した受診者から原発性副甲状腺機能亢進症のスクリーニングを行った．<br><b>方法：</b>1995年7月より2010年12月までの人間ドック受診者を対象とした．血清Ca，リンおよびアルブミン（Alb）値は自動分析機を用いて測定した．原発性副甲状腺機能亢進症のスクリーニングは，血清Ca値が高値（≧10.4mg/dL）を呈する症例に対して行った．このうち血清Alb値による補正Ca（cCa）値が高値（≧10.4mg/dL）を呈した症例に副甲状腺ホルモン（PTH）の測定を行った．また2001年7月から2010年12月までの人間ドック受診者について原発性副甲状腺機能亢進症と高Ca血症との関係について分析した．<br><b>成績：</b>1995年7月から2010年10月までの人間ドック受診者総数は1,936例，男性1,324例，女性612例で男性/女性比2.2であった．高Ca血症かつ高cCa血症を示した症例は2例あり，第1例は人間ドック開始時より817例目，第2例は1,737例目（症例1より920例目）で，2例ともPTH高値より原発性副甲状腺機能亢進症と診断した．2001年7月から2010年12月までの人間ドック受診者は1,615例で，高Ca血症を24例（1.5%），高cCa血症を3例に認めた．高cCa血症の中には原発性副甲状腺機能亢進症の2例（症例1および症例2）の他に多発性骨髄腫の1例が含まれていた．<br><b>結論：</b>人間ドックにおいて原発性副甲状腺機能亢進症のスクリーニングを行い817例目および1,737例目に本症を認めた．人間ドックにおいては約1/1,000の頻度で原発性副甲状腺機能亢進症が発見される可能性がある．

DOI： 10.11320/ningendock.26.498

記述言語：日本語

Basophilic granulocytes (basophils) are a very small population of peripheral blood leukocytes. Because basophils have high-affinity immunoglobulin E receptors (Fce{open}RI) and secrete chemical mediators that contain histamine, they are thought to be very similar to mast cells. However, research characterizing the function of basophils was slow to proceed and their unique function and importance were not established for a significant period of time. Recently, a series of studies have characterized the role of basophils in anaphylactic shock, chronic allergic reactions, and other human immunological reactions. These studies have shown that basophils are not a supplementary cell type but key players in very serious immune reactions. In this chapter we introduce the recently discovered characteristics of basophils. In addition, we consider how these aspects are clinically important and are connected with new cellular or molecular treatments for allergic reactions. © 2012 Nova Science Publishers, Inc. All rights reserved.

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記述言語：日本語

Basophilic granulocytes (basophils) are a very small population of peripheral blood leukocytes. Because basophils have high-affinity immunoglobulin E receptors (Fc?RI) and secrete chemical mediators that contain histamine, they are thought to be very similar to mast cells. However, research characterizing the function of basophils was slow to proceed and their unique function and importance were not established for a significant period of time. Recently, a series of studies have characterized the role of basophils in anaphylactic shock, chronic allergic reactions, and other human immunological reactions. These studies have shown that basophils are not a supplementary cell type but key players in very serious immune reactions. In this chapter we introduce the recently discovered characteristics of basophils. In addition, we consider how these aspects are clinically important and are connected with new cellular or molecular treatments for allergic reactions. © 2011 Nova Science Publishers, Inc. All rights reserved.

Scopus