Faculty Profiles - NAGATA Yuichi

Papers - NAGATA Yuichi

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Growth hormone-producing pituitary adenomas in childhood and young adulthood: clinical features and outcomes.

Nagata Y, Inoshita N, Fukuhara N, Yamaguchi-Okada M, Nishioka H, Iwata T, Yoshimoto K, Yamada S

Pituitary Vol. 21 ( 1 ) page： 1-9 2018.2

Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

Aoki, K; Nakamura, H; Suzuki, H; Matsuo, K; Kataoka, K; Shimamura, T; Motomura, K; Ohka, F; Shiina, S; Yamamoto, T; Nagata, Y; Yoshizato, T; Mizoguchi, M; Abe, T; Momii, Y; Muragaki, Y; Watanabe, R; Ito, I; Sanada, M; Yajima, H; Morita, N; Takeuchi, I; Miyano, S; Wakabayashi, T; Ogawa, S; Natsume, A

NEURO-ONCOLOGY Vol. 20 ( 1 ) page： 66 - 77 2018.1

Language：English Publisher：Neuro-Oncology

Background Diffuse lower-grade gliomas (LGGs) are genetically classified into 3 distinct subtypes based on isocitrate dehydrogenase (IDH) mutation status and codeletion of chromosome 1p and 19q (1p/19q). However, the subtype-specific effects of additional genetic lesions on survival are largely unknown. Methods Using Cox proportional hazards regression modeling, we investigated the subtype-specific effects of genetic alterations and clinicopathological factors on survival in each LGG subtype, in a Japanese cohort of LGG cases fully genotyped for driver mutations and copy number variations associated with LGGs (n = 308). The results were validated using a dataset from 414 LGG cases available from The Cancer Genome Atlas (TCGA). Results In Oligodendroglioma, IDH-mutant and 1p/19q codeleted, NOTCH1 mutations (P = 0.0041) and incomplete resection (P = 0.0019) were significantly associated with shorter survival. In Astrocytoma, IDH-mutant, PIK3R1 mutations (P = 0.0014) and altered retinoblastoma pathway genes (RB1, CDKN2A, and CDK4) (P = 0.013) were independent predictors of poor survival. In IDH-wildtype LGGs, co-occurrence of 7p gain, 10q loss, mutation in the TERT promoter (P = 0.024), and grade III histology (P < 0.0001) independently predicted poor survival. IDH-wildtype LGGs without any of these factors were diagnosed at a younger age (P = 0.042), and were less likely to have genetic lesions characteristic of glioblastoma, in comparison with other IDH-wildtype LGGs, suggesting that they likely represented biologically different subtypes. These results were largely confirmed in the cohort of TCGA. Conclusions Subtype-specific genetic lesions can be used to stratify patients within each LGG subtype. enabling better prognostication and management.

DOI： 10.1093/neuonc/nox132

Web of Science

Scopus

PubMed

Inherent Tumor Characteristics That Limit Effective and Safe Resection of Giant Nonfunctioning Pituitary Adenomas.

Nishioka H, Hara T, Nagata Y, Fukuhara N, Yamaguchi-Okada M, Yamada S

World neurosurgery Vol. 106 page： 645-652 2017.10

The Multiscope Technique for Microvascular Decompression

Nagata Yuichi, Watanabe Tadashi, Nagatani Tetsuya, Takeuchi Kazuhito, Chu Jonsu, Wakabayashi Toshihiko

WORLD NEUROSURGERY Vol. 103 page： 310 - 314 2017.7

Upward ballooning of the third ventricle floor in a patient with slit ventricle syndrome: A unique magnetic resonance imaging finding.

Yamaguchi J, Watanabe T, Nagata Y, Nagatani T, Seki Y

The neuroradiology journal Vol. 30 ( 1 ) page： 62-64 2017.2

Endoscopic resection of Brain stem cavernous malformations (BSCMs): Two illustrative cases and surgical methods employed

Chu J.

Japanese Journal of Neurosurgery Vol. 26 ( 3 ) page： 216 - 226 2017

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Papers - NAGATA Yuichi