Papers - TAMURA Takashi

Manuscript Smoking Behavior-related Genetic Variants and Lung Cancer Risk in Japanese: an Assessment by Mediation Analysis. Reviewed International journal

Yamamoto S, Koyanagi YN, Iwashita Y, Shinozaki T, Fujiwara Y, Sakakura N, Hara M, Nishida Y, Otonari J, Ikezaki H, Tanoue S, Koriyama C, Kasugai Y, Oze I, Koyama T, Tomida S, Michihata N, Nakamura Y, Suzuki S, Nakagawa-Senda H, Nagayoshi M, Kubo Y, Kato Y, Wakai K, Watanabe T, Ishizu M, Takashima N, Kadota A, Momozawa Y, Nakatochi M, Tamura T, Niimi A, Ito H, Matsuo K

Carcinogenesis     2025.3

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DOI： 10.1093/carcin/bgaf011

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Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study. Reviewed

Naoko Miyagawa, Naoyuki Takashima, Akiko Harada, Aya Kadota, Keiko Kondo, Katsuyuki Miura, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Yuriko N Koyanagi, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Rie Ibusuki, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Takeshi Watanabe, Masashi Ishizu, Asahi Hishida, Yoshikuni Kita, Kenji Wakai, Keitaro Matsuo

Journal of atherosclerosis and thrombosis   Vol. advpub ( 0 )   2024.11

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Atherosclerosis Society  

AIM: We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan. METHODS: We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.7 years old). The amount of dairy (milk and yogurt) intake was determined using a validated short-food frequency questionnaire. The hazard ratio for mortality according to sex-specific tertile of dairy intake was calculated using Cox proportional hazards regression models with adjustment for potential confounding factors and dietary factors by sex. RESULTS: During the follow-up period (932,738 person-years), 3,723 participants died, including 2,088 cancer and 530 cardiovascular disease deaths. The highest tertile of total dairy intake (versus the lowest tertile) was associated with a 19% lower all-cause mortality risk (hazard ratio=0.81, 95% confidence interval: 0.70-0.92; P for trend=0.001) in women. Similarly, we observed inverse associations between milk intake and all-cause and cancer mortality risk in women, yogurt intake and cardiovascular disease risk in women, and yogurt intake and all-cause mortality risk in both sexes. CONCLUSION: A higher total dairy and milk intakes in women and yogurt intake in both sexes were associated with a reduced risk of all-cause mortality in the general population across Japan during the 12-year follow-up period.

DOI： 10.5551/jat.65049

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The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Reviewed International journal Open Access

Takeshi Watanabe, Tien Van Nguyen, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masashi Ishizu, Taichi Unohara, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Hiroko Nakagawa-Senda, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Akiko Harada, Kenji Wakai, Keitaro Matsuo

Cancer research communications   Vol. 4 ( 11 ) page： 2986 - 2997   2024.11

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The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects for questionnaire-based analyses in the Japan Multi-Institutional Collaborative Cohort Study. Metabolic phenotypes were defined by classifying subjects according to their BMI (obesity: BMI ≥25 kg/m2; normal weight: BMI <25 kg/m2) and the number of metabolic abnormalities. Metabolic abnormalities were defined according to metabolic syndrome components of the Joint Interim Statement Criteria for examination-based analyses and self-reported histories of diabetes, dyslipidemia, and hypertension for questionnaire-based analyses. Cox proportional hazards regression analyses adjusted for potential confounders were performed for total and site-specific cancer incidence according to metabolic phenotypes. Metabolically unhealthy obesity (MUHO) was significantly associated with cancer incidence in both examination-based [HR (95% CI): 1.17 (1.01-1.36)] and questionnaire-based analyses [HR (95% CI): 1.15 (1.04-1.26)]. Regarding site-specific cancer in questionnaire-based analyses, metabolically healthy obesity and MUHO were associated with colorectum and liver cancers in all subjects and with breast cancer in female subjects. Subjects with a metabolically unhealthy normal weight had a higher risk of pancreatic cancer. Moreover, MUHO was associated with corpus uteri cancer in female subjects. This prospective cohort study suggests that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults.

DOI： 10.1158/2767-9764.CRC-24-0249

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Food group intakes and high-sensitivity C-reactive protein among community-dwelling Japanese adults: a cross-sectional study. Reviewed International journal Open Access

Takashi Matsunaga, Kenji Wakai, Nahomi Imaeda, Chiho Goto, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Hiroaki Ikezaki, Jun Otonari, Naoyuki Takashima, Naoko Miyagawa, Keitaro Matsuo

Public health nutrition   Vol. 27 ( 1 ) page： e212   2024.10

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OBJECTIVE: Healthy dietary patterns have been linked to lower levels of chronic inflammation. The present study aimed to investigate the associations between food group intakes and high-sensitivity C-reactive protein (hsCRP) among community-dwelling adults. DESIGN: Cross-sectional. SETTING: Three areas in Japan (Shiga, Fukuoka, or Kyushu and Okinawa). PARTICIPANTS: The present analysis included 13 648 participants (5126 males and 8522 females; age range, 35-69 years) who had been enrolled in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Food group intakes were estimated using a FFQ. Multiple linear regression was used to examine associations between the quartiles of each energy-adjusted food group intake and log-transformed hsCRP. RESULTS: The following concentration ratios of hsCRP after comparing the highest and lowest quartiles of food group intake were significant: in males, 1·12 (95 % CI 1·02, 1·22) for processed meat, 1·13 (95 % CI 1·03, 1·24) for fish and 0·83 (95 % CI 0·76, 0·90) for nuts; in females, 0·89 (95 % CI 0·81, 0·97) for bread, 1·11 (95 % CI 1·03, 1·19) for processed meat, 0·86 (95 % CI 0·80, 0·92) for vegetables, 1·19 (95 % CI 1·11, 1·29) for fruit, 0·90 (95 % CI 0·84, 0·97) for nuts and 0·88 (95 % CI 0·82, 0·95) for green tea. CONCLUSIONS: Processed meat and nut intakes were associated with higher and lower hsCRP levels, respectively, in both sexes. However, for several food groups, including fish and fruit, previous findings from dietary pattern analyses were not supported by the present analyses at the food group level.

DOI： 10.1017/S1368980024001599

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Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population. Reviewed International journal

Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, Hiroshi Okumiyama, Naoyuki Takashima, Yoshiki Tsuboi, Koji Suzuki, Hiroaki Ikezaki, Chisato Shimanoe, Yasufumi Kato, Takashi Tamura, Hidemi Ito, Nobuaki Michihata, Shiroh Tanoue, Sadao Suzuki, Kiyonori Kuriki, Aya Kadota, Takeshi Watanabe, Yukihide Momozawa, Kenji Wakai, Keitaro Matsuo

Hypertension research : official journal of the Japanese Society of Hypertension   Vol. 47 ( 9 ) page： 2284 - 2294   2024.7

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Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different genetic liability groups. This prospective study aimed to examine the associations of blood pressure PRS with all-cause and CVD mortality and to quantify the attributable risk by modifiable lifestyles across different PRS strata. 9,296 participants in the Japan Multi-Institutional Collaborative Cohort Study without hypertension at baseline were analyzed in this analysis. PRS for systolic blood pressure and diastolic blood pressure (PRSSBP and PRSDBP) were developed using publicly available Biobank Japan GWAS summary statistics. CVD-related mortality was defined by the International Classification of Diseases 10th version (I00-I99). Cox-proportional hazard model was used to examine associations of PRSs and lifestyle variables (smoking, drinking, and dietary sodium intake) with mortality. During a median 12.6-year follow-up period, we observed 273 all-cause and 41 CVD mortality cases. Compared to the middle PRS group (20-80th percentile), adjusted hazard ratios for CVD mortality at the top PRS group ( > 90th percentile) were 3.67 for PRSSBP and 2.92 for PRSDBP. Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group ( > 80th percentile) compared with the low PRS group (0-80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited.

DOI： 10.1038/s41440-024-01766-9

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Association between dysphagia risk and sleep quality in community-dwelling older adults: A cross-sectional study. Reviewed International journal Open Access

Yohko Hama, Sachiko Yamada, Rumi Nishimura, Mitsuyoshi Yoshida, Kazuhiro Tsuga, Emi Morita, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Kenji Wakai, Mariko Naito

Heliyon   Vol. 10 ( 11 ) page： e32028   2024.6

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OBJECTIVES: Exploring the effects of swallowing function on sleep quality could provide valuable insights into the potential impact of reduced swallowing function on sleep. However, pertinent studies are limited. Therefore, this study aimed to investigate the relationship between dysphagia risk and sleep health in community-dwelling older adults. METHODS: Data for this cross-sectional study were obtained from the Shizuoka and Daiko studies conducted as part of the Japan Multi-Institutional Collaborative Cohort Study. Information on demographics, overall lifestyle, dysphagia risk, as well as sleep quality, duration, satisfaction, and regularity, was obtained using a self-administered questionnaire. Dysphagia risk and sleep quality were assessed using the Dysphagia Risk Assessment Questionnaire for the Community-dwelling Elderly and the Japanese version of the Pittsburgh Sleep Questionnaire Index, respectively. Multivariate logistic regression, adjusted for covariates, was employed to assess the association between dysphagia risk and sleep health. RESULTS: Among the 3058 participants (1633 males, 1425 females) aged ≥60 years, 28.0 % exhibited dysphagia risk, and 19.1 % reported poor sleep quality. Those with dysphagia risk were more likely to experience poor sleep quality than those without dysphagia risk. In male participants, dysphagia was significantly associated with poor sleep quality, unsatisfactory sleep, and sleep irregularity, but was not significantly associated with unsatisfactory or irregular sleep in female participants. The Japanese version of the Pittsburgh Sleep Questionnaire Index components-subjective sleep quality, sleep latency, sleep disturbances, and daytime dysfunction-were associated with dysphagia risk in both sexes. CONCLUSIONS: Dysphagia risk is associated with sleep quality in older individuals in Japan. Thus, preserving swallowing function may contribute to enhancing sleep quality.

DOI： 10.1016/j.heliyon.2024.e32028

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Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan. Reviewed

Daisaku Nishimoto, Rie Ibusuki, Ippei Shimoshikiryo, Kenichi Shibuya, Shiroh Tanoue, Chihaya Koriyama, Toshiro Takezaki, Isao Oze, Hidemi Ito, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Yuichiro Nishida, Chisato Shimanoe, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Satomi Tomida, Kiyonori Kuriki, Naoko Miyagawa, Keiko Kondo, Kokichi Arisawa, Takeshi Watanabe, Hiroaki Ikezaki, Jun Otonari, Kenji Wakai, Keitaro Matsuo

Journal of epidemiology   Vol. 34 ( 0 ) page： 286 - 294   2024.6

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Epidemiological Association  

BACKGROUND: Improving diets requires an awareness of the need to limit foods for which excessive consumption is a health problem. Since there are limited reports on the link between this awareness and mortality risk, we examined the association between awareness of limiting food intake (energy, fat, and sweets) and all-cause mortality in a Japanese cohort study. METHODS: Participants comprised 58,772 residents (27,294 men; 31,478 women) aged 35-69 years who completed baseline surveys of the Japan Multi-Institutional Collaborative Cohort Study from 2004 to 2014. Hazard ratios (HRs) for all-cause mortality and 95% confidence intervals (CIs) were estimated by sex using a Cox proportional hazard model, with adjustment for related factors. Mediation analysis with fat intake as a mediator was also conducted. RESULTS: The mean follow-up period was 11 years and 2,516 people died. Estimated energy and fat intakes according to the Food Frequency Questionnaire were lower in those with awareness of limiting food intake than in those without this awareness. Women with awareness of limiting fat intake showed a significant decrease in mortality risk (HR=0.73; 95% CI, 0.55 to 0.94). Mediation analysis revealed that this association was due to the direct effect of the awareness of limiting fat intake and that the total effect was not mediated by actual fat intake. Awareness of limiting energy or sweets intake was not related to mortality risk reduction. CONCLUSION: Awareness of limiting food intake had a limited effect on reducing all-cause mortality risk.

DOI： 10.2188/jea.JE20220354

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Elevated level of urinary tellurium is a potential risk for increase of blood pressure in humans and mice. Reviewed International journal Open Access

Tomoko Misawa, Takumi Kagawa, Nobutaka Ohgami, Akira Tazaki, Shoko Ohnuma, Hisao Naito, Dijie Chen, Yishuo Gu, Takashi Tamura, Kenji Wakai, Kimitoshi Nishiwaki, Masashi Kato

Environment international   Vol. 188   page： 108735 - 108735   2024.6

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BACKGROUND: People worldwide are routinely exposed to tellurium mainly via dietary ingestion. There has been no study to clarify the contribution of tellurium to blood pressure in humans or animals. METHODS: In this cross-sectional study conducted in a general population of 2592 residents in Japan, the associations of urinary tellurium levels with blood pressure and prevalence of hypertension were investigated. The potential sources of tellurium were also investigated. An interventional study in mice confirmed the effect of tellurium exposure on blood pressure. RESULTS: Linear and logistic regression analyses with consideration of confounders including urinary sodium-potassium ratio showed significant positive associations of urinary tellurium level with prevalence of hypertension and blood pressure. Cereals/beans and vegetables/fruits were determined to be potential dietary sources of tellurium exposure. Intermediary analysis suggested that increased intake of cereals/beans, but not that of vegetables/fruits, is positively associated with the tellurium-mediated risk of hypertension. Correspondingly, the mouse study showed that exposure to a putative human-equivalent dose of tellurium via drinking water increased blood pressure with an elevated level of urinary tellurium. The temporally increased blood pressure was decreased to the normal level by a break of tellurium exposure with a reduced level of urinary tellurium. CONCLUSIONS: The interdisciplinary approach provided the first evidence that tellurium exposure is a potential risk for increase of blood pressure. Since the human urinary tellurium level in this study is comparable with the levels in general populations in other Asian and European countries in previous studies, exposure to tellurium may be a latent universal risk for hypertension.

DOI： 10.1016/j.envint.2024.108735

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GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study. Reviewed

Mineko Tsukamoto, Asahi Hishida, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Yasufumi Kato, Nobuyuki Hamajima, Yuichiro Nishida, Chisato Shimanoe, Rie Ibusuki, Kenichi Shibuya, Naoyuki Takashima, Yasuyuki Nakamura, Miho Kusakabe, Yohko Nakamura, Yuriko N Koyanagi, Isao Oze, Takeshi Nishiyama, Sadao Suzuki, Isao Watanabe, Daisuke Matsui, Jun Otonari, Hiroaki Ikezaki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, Keitaro Matsuo

Journal of epidemiology   Vol. 34   page： 228 - 237   2024.5

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Epidemiological Association  

BACKGROUND: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites as well as to detect related gene-environment interactions in Japanese. METHODS: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B12 (VB12) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene-environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed. RESULTS: For Hcy, MTHFR locus on chr 1, NOX4 on chr 11, CHMP1A on chr 16, and DPEP1 on chr 16 reached genome-wide significance (P < 5×10-8). MTHFR also associated with FA, and FUT2 on chr 19 associated with VB12. We investigated gene-environment interactions in both studies and found significant interactions between MTHFR C677T and ever drinking, current drinking, and physical activity > 33% on Hcy (β = 0.039, 0.038 and -0.054, P = 0.018, 0.021 and < 0.001, respectively) and the interaction of MTHFR C677T with ever drinking on FA (β = 0.033, P = 0.048). CONCLUSIONS: The present GWAS revealed the folate metabolism-associated genetic loci and gene-environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized CVD prevention.

DOI： 10.2188/jea.JE20220341

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Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal Open Access

Chinatsu Kasahara, Takashi Tamura, Kenji Wakai, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Asahi Hishida, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Ippei Shimoshikiryo, Sadao Suzuki, Miki Watanabe, Etsuko Ozaki, Chie Omichi, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Keitaro Matsuo

Public health nutrition   Vol. 27 ( 1 ) page： e135 - 40   2024.5

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OBJECTIVE: Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify the association between intake of small fish and all-cause and cause-specific mortality. DESIGN: We used the data from a cohort study in Japan. The frequency of the intake of small fish was assessed using a validated food frequency questionnaire. The hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality according to the frequency of the intake of small fish by sex were estimated using a Cox proportional hazard model with adjustments for covariates. SETTING: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. PARTICIPANTS: A total of 80,802 participants (34,555 males and 46,247 females), aged 35-69 years. RESULTS: During a mean follow-up of 9.0 years, we identified 2,482 deaths including 1,495 cancer-related deaths. The intake of small fish was statistically significantly and inversely associated with the risk of all-cause and cancer mortality in females. The multivariable-adjusted HRs (95% CIs) in females for all-cause mortality according to the intake were 0.68 (0.55-0.85) for intakes 1-3 times/month, 0.72 (0.57-0.90) for 1-2 times/week, and 0.69 (0.54-0.88) for ≥3 times/week, compared with the rare intake. The corresponding HRs (95% CIs) in females for cancer mortality were 0.72 (0.54-0.96), 0.71 (0.53-0.96), and 0.64 (0.46-0.89), respectively. No statistically significant association was observed in males. CONCLUSIONS: Intake of small fish may reduce the risk of all-cause and cancer mortality in Japanese females.

DOI： 10.1017/S1368980024000831

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The Inverse Association between the Frequency of Forest Walking (Shinrin-yoku) and the Prevalence of Insomnia Symptoms in the General Japanese Population: A Japan Multi-Institutional Collaborative Cohort Daiko Study.

Morita E, Kadotani H, Yamada N, Sasakabe T, Kawai S, Naito M, Tamura T, Wakai K

International journal of environmental research and public health   Vol. 21 ( 3 )   2024.3

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Language：English   Publisher：International Journal of Environmental Research and Public Health  

Since a single forest walk (Shinrin-yoku or forest bathing) session is reported to improve sleep temporarily, occasional forest walks may have a positive effect on daily sleep. Therefore, this study aimed to examine whether more frequent forest walking is associated with better daily sleep conditions. Data from the second survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Daiko Study conducted among residents of Nagoya City, Japan, were used. The study design was a cross-sectional study. In total, 2044 participants (529 men and 1515 women; age, mean ± standard deviation: 58.8 ± 9.9 years) were included in the analysis. Frequent forest walks were associated with a low percentage of insomnia symptoms (Insomnia Severity Index ≥10) in women, but not in men. The adjusted odds ratio for the group that rarely took forest walks with reference to the group that engaged in the activity once a month or more often was 2.04 (95% confidence interval: 1.29–3.23) in women. Forest walk frequency was not significantly associated with sleep duration or sleep efficiency as measured by actigraphy in either men or women. In conclusion, the results suggested that increasing the frequency of forest walks or Shinrin-yoku may be effective in preventing insomnia in women.

DOI： 10.3390/ijerph21030350

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BMI and cardiometabolic traits in Japanese: a Mendelian randomization study. Reviewed

Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai

Journal of epidemiology   Vol. 34   page： 51 - 62   2024.2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Epidemiological Association  

BACKGROUND: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. METHODS: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study, and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses by the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. RESULTS: In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with higher risks of higher blood pressure, triglycerides, uric acid, lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent by different methods, including the directions. CONCLUSIONS: The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.

DOI： 10.2188/jea.JE20220154

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Seven‐plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi‐Institutional Collaborative Cohort Study Reviewed

Satomi Tomida, Teruhide Koyama, Etsuko Ozaki, Naoyuki Takashima, Midori Morita, Koichi Sakaguchi, Yasuto Naoi, Yuichiro Nishida, Megumi Hara, Asahi Hishida, Takashi Tamura, Rieko Okada, Yoko Kubo, Jun Otonari, Hiroaki Ikezaki, Yohko Nakamura, Miho Kusakabe, Shiroh Tanoue, Chihaya Koriyama, Yuriko N. Koyanagi, Hidemi Ito, Sadao Suzuki, Takahiro Otani, Naoko Miyagawa, Yukiko Okami, Kokichi Arisawa, Takeshi Watanabe, Kiyonori Kuriki, Kenji Wakai, Keitaro Matsuo

Cancer Science   Vol. 115   page： 611 - 622   2024.2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

Abstract

This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35–69 years from the Japan Multi‐Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: &lt;7 and ≥7 hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure‐time metabolic equivalents (METs), frequency of leisure‐time physical activity, and daily walking time, were examined. During 315,189 person‐years of follow‐up, 554 incident cases of BC were identified. When compared to participants who spent &lt;7 h/d sedentary, those who spent ≥7 h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07–1.71). The corresponding HRs among participants who spent ≥7 h/d sedentary with more physical activity, such as ≥1 h/d for leisure‐time METs, ≥3 days/week of leisure‐time physical activity, and ≥1 h/d of daily walking were 1.58 (95% CI, 1.11–2.25), 1.77 (95% CI, 1.20–2.61), and 1.42 (95% CI, 1.10–1.83), respectively, compared with those who spent &lt;7 h/d sedentary. This study found that spending ≥7 h/d of sedentary time is associated with the risk of BC. Neither leisure‐time physical activity nor walking had a BC‐preventive effect in those with ≥7 h/d of sedentary time.

DOI： 10.1111/cas.16020

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Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice. Reviewed International journal Open Access

Takumi Kagawa, Nobutaka Ohgami, Tingchao He, Akira Tazaki, Shoko Ohnuma, Hisao Naito, Ichiro Yajima, Dijie Chen, Yuqi Deng, Takashi Tamura, Takaaki Kondo, Kenji Wakai, Masashi Kato

European heart journal open   Vol. 3 ( 5 ) page： oead074   2023.9

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AIMS: There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies. METHODS AND RESULTS: This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and hypertension and a positive association between the ingestion of fish meat and hypertension. Further analysis showed that the latter association was fully mediated by increased fasting serum arsenic levels in humans. Similarly, oral exposure to the putative human-equivalent dose of arsenic species mixture with the same ratios in a common fish meat in Japan increased systolic blood pressure and arsenic levels in fasting serum in mice. CONCLUSION: This interdisciplinary approach suggests that fish-meat ingestion is a potential risk factor for arsenic-mediated hypertension. Because the increased consumption of fish meat is a recent global trend, health risks of the increased ingestion of arsenic via fish meat should be further investigated.

DOI： 10.1093/ehjopen/oead074

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Dietary carbohydrate and fat intakes and risk of mortality in the Japanese population: the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal

Takashi Tamura, Kenji Wakai, Yasufumi Kato, Yudai Tamada, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Asahi Hishida, Nahomi Imaeda, Chiho Goto, Hiroaki Ikezaki, Jun Otonari, Megumi Hara, Keitaro Tanaka, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Chihaya Koriyama, Isao Oze, Hidemi Ito, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Keiko Kondo, Naoyuki Takashima, Takeshi Watanabe, Sakurako Katsuura-Kamano, Keitaro Matsuo

The Journal of nutrition   Vol. 153 ( 8 ) page： 2352 - 2368   2023.8

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BACKGROUND: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risk of mortality. OBJECTIVES: We examined long-term associations of carbohydrate and fat intakes with mortality. METHODS: In this cohort study, 34,893 men and 46,440 women aged 35-69 years (mean body mass index 23.7 and 22.2 kg/m2, respectively) were followed from the baseline survey (2004-2014) to the end of 2017 or 2018. Intakes of carbohydrate, fat, and total energy were estimated using a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for all-cause and cause-specific mortality according to percent energy intakes of carbohydrate and fat. RESULTS: During a mean 8.9 years of follow-up, we identified 2,783 deaths (1,838 men and 945 women). Compared with men who consumed 50%-<55% of energy from carbohydrate, those that consumed <40% carbohydrate energy had a significantly higher risk of all-cause mortality (the multivariable-adjusted HR: 1.59; 95% CI: 1.19-2.12; P-trend = 0.002). Among women with 5 years or longer of follow-up, women with high carbohydrate intake had a higher risk for all-cause mortality; the multivariable-adjusted HR (95% CI) was 1.71 (0.93-3.13) for ≥65% of energy from carbohydrate compared with 50%-<55% (P-trend = 0.005). Men with high fat intake had a higher risk for cancer mortality; the multivariable-adjusted HR (95% CI) for ≥35% was 1.79 (1.11-2.90) compared with 20%-<25%. Fat intake was marginally inversely associated with the risk for all-cause and cancer mortality in women (P-trend = 0.054 and 0.058, respectively). CONCLUSIONS: An unfavorable association with mortality was observed for low carbohydrate intake in men and for high carbohydrate intake in women. High fat intake could be associated with a lower mortality risk in women among Japanese adults with a relatively high carbohydrate intake.

DOI： 10.1016/j.tjnut.2023.05.027

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Association of daily physical activity and leisure-time exercise with dysphagia risk in community-dwelling older adults: a cross-sectional study. Reviewed International journal

Tomoko Maehara, Rumi Nishimura, Akari Yoshitake, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Kenji Wakai, Mariko Naito

Scientific reports   Vol. 13 ( 1 ) page： 10893 - 10893   2023.7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

This study aimed to clarify the association of daily physical activity and leisure-time exercise with the risk of dysphagia in community-dwelling Japanese older adults using a questionnaire-based survey. We analyzed 3070 participants (1657 men, 1413 women; age 66 ± 4 years [mean ± SD]) of the Shizuoka and Daiko studies within the Japanese Multi-Institutional Collaborative Cohort study. We used the Dysphagia Risk Assessment for the Community-dwelling Elderly questionnaire to assess dysphagia risk and the International Physical Activity Questionnaire to assess daily physical activity and leisure-time exercise. Logistic regression analyses were used to evaluate the independent association of the amount of physical activity and leisure-time exercise with dysphagia risk. The proportion of participants with dysphagia risk was 27.5% (n = 844) and the risk was significantly higher in women (29.8%, n = 421) than in men (25.5%, n = 423; P = 0.008). Daily physical activity was not associated with dysphagia risk. A greater amount of leisure-time exercise was associated with lower dysphagia risk (P for trend = 0.003) and individuals in the highest leisure-time exercise quartile had a significantly lower odds ratio (0.68, 95% CI 0.52-0.89) than those in the lowest quartile, even after adjusting for the covariates.

DOI： 10.1038/s41598-023-37605-z

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Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population. Reviewed

Takuya Sakashita, Yasuyuki Nakamura, Yoichi Sutoh, Atsushi Shimizu, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Naoyuki Takashima, Aya Kadota, Katsuyuki Miura, Yoshikuni Kita, Hiroaki Ikezaki, Jun Otonari, Keitaro Tanaka, Chisato Shimanoe, Teruhide Koyama, Isao Watanabe, Sadao Suzuki, Hiroko Nakagawa-Senda, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Kiyonori Kuriki, Sakurako Katsuura-Kamano, Takeshi Watanabe, Shiroh Tanoue, Chihaya Koriyama, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Masahiro Nakatochi, Yukihide Momozawa, Kenji Wakai, Keitaro Matsuo

Diabetology international   Vol. 14 ( 2 ) page： 188 - 198   2023.4

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AIMS: Hemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes. However, estimates of the heritability of HbA1c and glucose levels are different. Therefore, we explored HbA1c- and blood glucose-associated loci in a non-diabetic Japanese population. METHODS: We conducted a two-stage genome-wide association study (GWAS) on variants associated with HbA1c and blood glucose levels in a Japanese population. In the initial stage, data of 4911 participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) were subjected to discovery analysis. In the second stage, two datasets from the Tohoku Medical Megabank project, with 8175 and 40,519 participants, were used for the replication study. Association of the imputed variants with HbA1c and blood glucose levels was determined via linear regression analyses adjusted for age, sex, body mass index (BMI), smoking, and genetic principal components (PC1-PC10). Moreover, we performed a BMI-stratified GWAS on HbA1c levels in the J-MICC. The discovery analysis and BMI-stratified GWAS results were validated with re-analyses of normalized HbA1c levels adjusted for site in addition to the above, and blood glucose adjusted for fasting time as an additional covariate. RESULTS: Genetic variants associated with HbA1c levels were identified in KCNQ1 and TMC6. None of the genetic variants associated with blood glucose levels in the discovery analysis were replicated. Association of rs2299620 in KCNQ1 with HbA1c levels showed heterogeneity between individuals with BMI ≥ 25 kg/m2 and BMI < 25 kg/m2. CONCLUSIONS: The variant rs2299620 in KCNQ1 might affect HbA1c levels differentially based on BMI grouping in the Japanese population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-023-00618-0.

DOI： 10.1007/s13340-023-00618-0

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Questionnaire-assessed physical activity among Japanese adults: The J-MICC Study

Saito Yoshinobu, Oguma Yuko, Nakamura Sho, Narimatsu Hiroto, Nakashima Ryoko, Ikezaki Hiroaki, Tanaka Keitaro, Hara Megumi, Tamada Yudai, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Oze Isao, Taniyama Yukari, Mikami Haruo, Nagase Hiroki, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Otani Takahiro, Koyama Teruhide, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Takashima Naoyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Takeuchi Kenji, Wakai Kenji, J-MICC Study Group

Research in Exercise Epidemiology   Vol. 25 ( 1 ) page： 112 - 113   2023.3

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Association of Exercise Epidemiology  

DOI： 10.24804/ree.2154

CiNii Research

Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Reviewed International journal

Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kenji Wakai, Keitaro Matsuo

Nutrition, Metabolism and Cardiovascular Diseases   Vol. 33 ( 3 ) page： 620 - 630   2023.3

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.numecd.2022.12.019

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Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis. Reviewed International journal Open Access

Sho Nakamura, Xuemin Fang, Yoshinobu Saito, Hiroto Narimatsu, Azusa Ota, Hiroaki Ikezaki, Chisato Shimanoe, Keitaro Tanaka, Yoko Kubo, Mineko Tsukamoto, Takashi Tamura, Asahi Hishida, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Toshiro Takezaki, Daisaku Nishimoto, Sadao Suzuki, Takahiro Otani, Nagato Kuriyama, Daisuke Matsui, Kiyonori Kuriki, Aya Kadota, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai

PloS one   Vol. 18 ( 2 ) page： e0279169   2023

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BACKGROUND: The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene-environment interactions, has been attracting attention in recent years. However, evidence for gene-environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene-lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. METHODS: This study aimed to elucidate the effects of gene-lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. RESULTS: The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r(12,916) = 0.13 (95% confidence interval [CI] 0.11-0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). CONCLUSION: Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene-lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.

DOI： 10.1371/journal.pone.0279169

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