研究者詳細 - 橋詰　淳

論文 - 橋詰　淳

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CENTRAL MOTOR CONDUCTION TIME (CMCT) IN PATIENTS WITH SPINAL AND BULBAR MUSCULAR ATROPHY (SBMA) 査読有り

Suzuki, K; Katsuno, M; Banno, H; Suga, N; Hashizume, A; Hara, T; Hama, T; Nakamura, T; Hirayama, M; Tanaka, F; Sobue, G

EUROPEAN JOURNAL OF NEUROLOGY 18 巻頁： 222 - 222 2011年9月

Endoscopic third ventriculotomy improves Parkinsonism following a ventriculo-peritoneal shunt in a patient with non communicating hydrocephalus secondary to idiopathic aqueduct stenosis 査読有り

Hashizume, A; Watanabe, H; Matsuo, K; Katsuno, M; Tanaka, F; Nagatani, T; Sobue, G

JOURNAL OF THE NEUROLOGICAL SCIENCES 309 巻 ( 1-2 ) 頁： 148 - 150 2011年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of the Neurological Sciences

We report a 47-year-old woman who manifested ocular motility disorder, bilateral pyramidal signs, and severe parkinsonism after a ventriculo-peritoneal shunt for non communicating hydrocephalus secondary to idiopathic aqueduct stenosis. The ocular motility disorder consisted of severe vertical gaze palsy and convergence retraction nystagmus. Parkinsonism included not only bradykinesia but also resting tremor and cogwheel rigidity. On the other hand, striatal uptake did not decrease in 18F-dihydroxyphenylalanine positron emission tomography, and anti-Parkinsonian drugs were not effective. 99mTc-ethyl cysteinate dimer bicisate single-photon emission computed tomography and F-18 fluorodeoxyglucose positron emission tomography revealed wide-ranged frontal cerebral cortical dysfunction due to midbrain dysfunction. Moreover, endoscopic third ventriculotomy markedly improved the clinical symptoms as well as the frontal cerebral cortical flow. A neural network formation known as the 'cortico-basal ganglia loop,' which intimately connects the frontal lobe with the basal ganglia, is possibly associated with the Parkinsonism observed in our patient. © 2011 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jns.2011.07.025

Web of Science

Scopus

PubMed

Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy 査読有り

Hashizume, A; Koike, H; Kawagashira, Y; Banno, H; Suzuki, K; Ito, M; Katsuno, M; Watanabe, H; Tanaka, F; Naganawa, S; Kaneko, R; Ishii, A; Sobue, G

CLINICAL NEUROLOGY AND NEUROSURGERY 113 巻 ( 6 ) 頁： 493 - 495 2011年

SCA3における末梢神経障害とシュワン細胞内凝集体査読有り

須賀徳明, 橋詰淳, 川島基, 鈴木啓介, 坂野晴彦, 勝野雅央, 祖父江元

臨床神経学 50 巻 ( 12 ) 頁： 1156 - 1156 2010年12月

球脊髄性筋萎縮症(SBMA)における自然歴の検討査読有り

橋詰淳, 須賀徳明, 川島基, 鈴木啓介, 坂野晴彦, 勝野雅央, 祖父江元

臨床神経学 50 巻 ( 12 ) 頁： 1197 - 1197 2010年12月

球脊髄性筋萎縮症における運動単位推定数(MUNE)の特徴査読有り

鈴木啓介, 勝野雅央, 坂野晴彦, 川島基, 須賀徳明, 橋詰淳, 濱哲夫, 内田圭, 中村友彦, 平山正昭, 田中章景, 祖父江元

臨床神経学 50 巻 ( 12 ) 頁： 1197 - 1197 2010年12月

球脊髄性筋萎縮症における嚥下造影の定性的・定量的解析査読有り

坂野晴彦, 勝野雅央, 鈴木啓介, 田中誠也, 川島基, 須賀徳明, 橋詰淳, 藤本保志, 山本正彦, 祖父江元

臨床神経学 50 巻 ( 12 ) 頁： 1197 - 1197 2010年12月

球脊髄性筋萎縮症(SBMA)の心筋におけるNaチャンネル機能の解析査読有り

勝野雅央, 坂野晴彦, 鈴木啓介, 川島基, 須賀徳明, 橋詰淳, 田中章景, 祖父江元

臨床神経学 50 巻 ( 12 ) 頁： 1127 - 1127 2010年12月

球脊髄性筋萎縮症(SBMA)における血管内皮細胞増殖因子(VEGF)の関与査読有り

川島基, 勝野雅央, 坂野晴彦, 鈴木啓介, 須賀徳明, 橋詰淳, 足立弘明, 田中章景, 祖父江元

臨床神経学 50 巻 ( 12 ) 頁： 1197 - 1197 2010年12月

The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy 査読有り国際誌

Suzuki, K; Katsuno, M; Banno, H; Takeuchi, Y; Kawashima, M; Suga, N; Hashizume, A; Hama, T; Uchida, K; Yamashita, F; Nakamura, T; Hirayama, M; Tanaka, F; Sobue, G

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 81 巻 ( 5 ) 頁： 567 - 71 2010年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neurology, Neurosurgery and Psychiatry

Objective: Spinal and bulbar muscular atrophy (SBMA) is a lower motor neuron disease caused by the expansion of a trinucleotide CAG repeat in the androgen receptor (AR) gene. The fundamental histopathological finding of this disease is an extensive loss of lower motor neurons in the spinal cord and brainstem. It is, however, difficult to evaluate clinically the degree of motor neuron degeneration, which stresses the need for biomarkers to detect the remaining neuronal function. Methods: The authors performed motor unit number estimation (MUNE) in 52 patients with SBMA, to investigate whether this method could be a potential biomarker of SBMA, and re-evaluated MUNE 1 year later in a subgroup of the patients. Results: The number of functioning motor units was remarkably reduced in patients with SBMA compared with controls, and was correlated with both ipsilateral grip power and disease duration. A longitudinal analysis demonstrated a further reduction in motor units within 1 year. Conclusions: The results suggest that MUNE is an electrophysiological parameter that reflects the severity and progression of motor neuron degeneration in patients with SBMA.

DOI： 10.1136/jnnp.2009.190462

Web of Science

Scopus

PubMed

球脊髄性筋萎縮症(SBMA)における自然歴の検討査読有り

橋詰淳, 須賀徳明, 川島基, 竹内優, 鈴木啓介, 坂野晴彦, 勝野雅央, 祖父江元

臨床神経学 50 巻 ( 2 ) 頁： 119 - 119 2010年2月

Parkinson病様症状を呈した原発性側索硬化症の1例査読有り

橋詰淳, 曽根淳, 伊藤瑞規, 熱田直樹, 渡辺宏久, 田中章景, 祖父江元

臨床神経学 50 巻 ( 2 ) 頁： 120 - 120 2010年2月

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