Faculty Profiles - HASHIZUME Atsushi

Papers - HASHIZUME Atsushi

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CENTRAL MOTOR CONDUCTION TIME (CMCT) IN PATIENTS WITH SPINAL AND BULBAR MUSCULAR ATROPHY (SBMA) Reviewed

K. Suzuki, M. Katsuno, H. Banno, N. Suga, A. Hashizume, T. Hara, T. Hama, T. Nakamura, M. Hirayama, F. Tanaka, G. Sobue

EUROPEAN JOURNAL OF NEUROLOGY Vol. 18 page： 222 - 222 2011.9

Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy Reviewed

Hashizume, A., Koike, H., Kawagashira, Y., Banno, H., Suzuki, K., Ito, M., Katsuno, M., Watanabe, H., Tanaka, F., Naganawa, S., Kaneko, R., Ishii, A., Sobue, G.

Clinical Neurology and Neurosurgery Vol. 113 ( 6 ) page： 493 - 495 2011

Endoscopic third ventriculotomy improves Parkinsonism following a ventriculo-peritoneal shunt in a patient with non communicating hydrocephalus secondary to idiopathic aqueduct stenosis Reviewed

Hashizume, A., Watanabe, H., Matsuo, K., Katsuno, M., Tanaka, F., Nagatani, T., Sobue, G.

Journal of the Neurological Sciences Vol. 309 ( 1-2 ) page： 148 - 150 2011

SCA3における末梢神経障害とシュワン細胞内凝集体 Reviewed

須賀徳明, 橋詰淳, 川島基, 鈴木啓介, 坂野晴彦, 勝野雅央, 祖父江元

臨床神経学 Vol. 50 ( 12 ) page： 1156 - 1156 2010.12

球脊髄性筋萎縮症における嚥下造影の定性的・定量的解析 Reviewed

坂野晴彦, 勝野雅央, 鈴木啓介, 田中誠也, 川島基, 須賀徳明, 橋詰淳, 藤本保志, 山本正彦, 祖父江元

臨床神経学 Vol. 50 ( 12 ) page： 1197 - 1197 2010.12

球脊髄性筋萎縮症(SBMA)の心筋におけるNaチャンネル機能の解析 Reviewed

勝野雅央, 坂野晴彦, 鈴木啓介, 川島基, 須賀徳明, 橋詰淳, 田中章景, 祖父江元

臨床神経学 Vol. 50 ( 12 ) page： 1127 - 1127 2010.12

球脊髄性筋萎縮症(SBMA)における血管内皮細胞増殖因子(VEGF)の関与 Reviewed

川島基, 勝野雅央, 坂野晴彦, 鈴木啓介, 須賀徳明, 橋詰淳, 足立弘明, 田中章景, 祖父江元

臨床神経学 Vol. 50 ( 12 ) page： 1197 - 1197 2010.12

球脊髄性筋萎縮症(SBMA)における自然歴の検討 Reviewed

橋詰淳, 須賀徳明, 川島基, 鈴木啓介, 坂野晴彦, 勝野雅央, 祖父江元

臨床神経学 Vol. 50 ( 12 ) page： 1197 - 1197 2010.12

球脊髄性筋萎縮症における運動単位推定数(MUNE)の特徴 Reviewed

鈴木啓介, 勝野雅央, 坂野晴彦, 川島基, 須賀徳明, 橋詰淳, 濱哲夫, 内田圭, 中村友彦, 平山正昭, 田中章景, 祖父江元

臨床神経学 Vol. 50 ( 12 ) page： 1197 - 1197 2010.12

The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy. Reviewed International journal

Keisuke Suzuki, Masahisa Katsuno, Haruhiko Banno, Yu Takeuchi, Motoshi Kawashima, Noriaki Suga, Atsushi Hashizume, Tetsuo Hama, Kei Uchida, Fumitada Yamashita, Tomohiko Nakamura, Masaaki Hirayama, Fumiaki Tanaka, Gen Sobue

Journal of neurology, neurosurgery, and psychiatry Vol. 81 ( 5 ) page： 567 - 71 2010.5

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Spinal and bulbar muscular atrophy (SBMA) is a lower motor neuron disease caused by the expansion of a trinucleotide CAG repeat in the androgen receptor (AR) gene. The fundamental histopathological finding of this disease is an extensive loss of lower motor neurons in the spinal cord and brainstem. It is, however, difficult to evaluate clinically the degree of motor neuron degeneration, which stresses the need for biomarkers to detect the remaining neuronal function. METHODS: The authors performed motor unit number estimation (MUNE) in 52 patients with SBMA, to investigate whether this method could be a potential biomarker of SBMA, and re-evaluated MUNE 1 year later in a subgroup of the patients. RESULTS: The number of functioning motor units was remarkably reduced in patients with SBMA compared with controls, and was correlated with both ipsilateral grip power and disease duration. A longitudinal analysis demonstrated a further reduction in motor units within 1 year. CONCLUSIONS: The results suggest that MUNE is an electrophysiological parameter that reflects the severity and progression of motor neuron degeneration in patients with SBMA.

DOI： 10.1136/jnnp.2009.190462

Web of Science

Scopus

PubMed

球脊髄性筋萎縮症(SBMA)における自然歴の検討 Reviewed

橋詰淳, 須賀徳明, 川島基, 竹内優, 鈴木啓介, 坂野晴彦, 勝野雅央, 祖父江元

臨床神経学 Vol. 50 ( 2 ) page： 119 - 119 2010.2

Parkinson病様症状を呈した原発性側索硬化症の1例 Reviewed

橋詰淳, 曽根淳, 伊藤瑞規, 熱田直樹, 渡辺宏久, 田中章景, 祖父江元

臨床神経学 Vol. 50 ( 2 ) page： 120 - 120 2010.2

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Papers - HASHIZUME Atsushi