研究者詳細 - 赤塚　美樹

論文 - 赤塚　美樹

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特集 CAR-T細胞療法の最前線--現状と残された課題はじめに

赤塚美樹

医学のあゆみ 288 巻 ( 3 ) 頁： 181 - 181 2024年1月

Development of TCR-T cell therapy targeting mismatched HLA-DPB1 for relapsed leukemia after allogeneic transplantation 査読有り国際誌

Barakat Carolyne, Inagaki Yuichiro, Mizuno Shohei, Nishio Nobuhiro, Katsuyama Naoya, Sato Yoshie, Kobayashi Miki, Ozeki Kazutaka, Iida Hiroatsu, Tomita Akihiro, Sawa Masashi, Demachi-Okamura Ayako, Takahashi Yoshiyuki, Nishikawa Hiroyoshi, Akatsuka Yoshiki

INTERNATIONAL JOURNAL OF HEMATOLOGY 118 巻 ( 2 ) 頁： 252 - 266 2023年8月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Hematology

Relapsed leukemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a significant challenge, with the re-emergence of the primary disease being the most frequent cause of death. Human leukocyte antigen (HLA)-DPB1 mismatch occurs in approximately 70% of unrelated allo-HSCT cases, and targeting mismatched HLA-DPB1 is considered reasonable for treating relapsed leukemia following allo-HSCT if performed under proper conditions. In this study, we established several clones restricted to HLA-DPB1*02:01, -DPB1*04:02, and -DPB1*09:01 from three patients who underwent HLA-DPB1 mismatched allo-HSCT using donor-derived alloreactive T cells primed to mismatched HLA-DPB1 in the recipient’s body after transplantation. A detailed analysis of the DPB1*09:01-restricted clone 2A9 showed reactivity against various leukemia cell lines and primary myeloid leukemia blasts, even with low HLA-DP expression. T cell receptor (TCR)-T cells derived from clone 2A9 retained the ability to trigger HLA-DPB1*09:01-restricted recognition and lysis of various leukemia cell lines in vitro. Our study demonstrated that the induction of mismatched HLA-DPB1 specific T cell clones from physiologically primed post-allo-HSCT alloreactive CD4+ T cells and the redirection of T cells with cloned TCR cDNA by gene transfer are feasible as techniques for future adoptive immunotherapy.

DOI： 10.1007/s12185-023-03621-y

Web of Science

Scopus

PubMed

TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens 招待有り査読有り国際誌

Akatsuka Yoshiki

FRONTIERS IN IMMUNOLOGY 11 巻頁： 257 - 257 2020年2月

Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H. 査読有り

Inaguma Y, Akahori Y, Murayama Y, Shiraishi K, Tsuzuki-Iba S, Endoh A, Tsujikawa J, Demachi-Okamura A, Hiramatsu K, Saji H, Yamamoto Y, Yamamoto N, Nishimura Y, Takahashi T, Kuzushima K, Emi N, Akatsuka Y

Gene therapy 21 巻頁： 575-584 2014年6月

HapMap scanning of novel human minor histocompatibility antigens. 査読有り

Kamei M, Nannya Y, Torikai H, Kawase T, Taura K, Inamoto Y, Takahashi T, Yazaki M, Morishima S, Tsujimura K, Miyamura K, Ito T, Togari H, Riddell SR, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y

Blood 113 巻頁： 5041-5048 2009年5月

Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA. 査読有り

Kawase T, Nannya Y, Torikai H, Yamamoto G, Onizuka M, Morishima S, Tsujimura K, Miyamura K, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y

Blood 111 巻頁： 3286-3294 2008年3月

Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen. 査読有り

Kawase T, Akatsuka Y, Torikai H, Morishima S, Oka A, Tsujimura A, Miyazaki M, Tsujimura K, Miyamura K, Ogawa S, Inoko H, Morishima Y, Kodera Y, Kuzushima K, Takahashi T

Blood 110 巻頁： 1055-1063 2007年8月

A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. 査読有り

Torikai H, Akatsuka Y, Miyazaki M, Warren EH 3rd, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T

Journal of immunology (Baltimore, Md. : 1950) 173 巻頁： 7046-7054 2004年12月

The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. 査読有り

Brickner AG, Warren EH, Caldwell JA, Akatsuka Y, Golovina TN, Zarling AL, Shabanowitz J, Eisenlohr LC, Hunt DF, Engelhard VH, Riddell SR

The Journal of experimental medicine 193 巻頁： 195-206 2001年1月

T cell receptor-engineered T cells derived from target human leukocyte antigen-DPB1-specific T cell can be a potential tool for therapy against leukemia relapse following allogeneic hematopoietic cell transplantation 査読有り

Katsuyama N, Kawase T, Barakat C, Mizuno S, Tomita A, Ozeki K, Nishio N, Sato Y, Kajiya R, Shiraishi K, akahashi Y, Ichinohe T, Nishikawa H, Akatsuka Y

Nagoya J Med Sci 85 巻 ( 7 ) 頁： 779 - 796 2023年11月

CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma 査読有り国際誌

Okamoto Akinao, Fujigaki Hidetsugu, Iriyama Chisako, Goto Naoe, Yamamoto Hideyuki, Mihara Keichiro, Inaguma Yoko, Miura Yasuo, Furukawa Katsuya, Yamamoto Yukiya, Akatsuka Yoshiki, Kasahara Senji, Miyao Kotaro, Tokuda Masutaka, Sato Seiko, Mizutani Yuki, Osawa Michiko, Hattori Keiko, Iba Sachiko, Kajiya Ryoko, Okamoto Masataka, Saito Kuniaki, Tomita Akihiro

BLOOD ADVANCES 6 巻 ( 11 ) 頁： 3230 - 3233 2022年6月

A simple method to distinguish residual elotuzumab from monoclonal paraprotein in immunofixation assays for multiple myeloma patients 査読有り

Chen Shurui, Kiguchi Toru, Nagata Yasuyuki, Tamai Yotaro, Ikeda Takeshi, Kajiya Ryoko, Ono Takaaki, Sugiyama Daisuke, Nishikawa Hiroyoshi, Akatsuka Yoshiki

INTERNATIONAL JOURNAL OF HEMATOLOGY 2021年1月

Improving TCR affinity on 293T cells 査読有り国際誌

Ohta Rieko, Demachi-Okamura Ayako, Akatsuka Yoshiki, Fujiwara Hiroshi, Kuzushima Kiyotaka

JOURNAL OF IMMUNOLOGICAL METHODS 466 巻頁： 1 - 8 2019年3月

Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.

Leukemia 2019年1月

[Progress in immune checkpoint inhibitor therapies].

Akatsuka Y

[Rinsho ketsueki] The Japanese journal of clinical hematology 60 巻 ( 9 ) 頁： 1341 - 1350 2019年

記述言語：日本語出版者・発行元：一般社団法人日本血液学会

<p>世界初の免疫チェックポイント阻害抗体であるiplimumabが転移性悪性黒色腫に対してアメリカ食品医薬品局（FDA）により2011年に承認されてからすでに8年が経過した。この間に複数の免疫チェックポイント阻害剤が開発され，悪性黒色腫を含む数種のがんに対して承認を受けてきたが，問題点も浮かび上がってきた。すなわち単独投与での奏効率が多くのがんで30％を超えないこと，免疫チェックポイント阻害剤2剤併用療法では奏効率は上がるものの免疫関連有害事象も重篤化することである。このため，投与後の臨床検体を用いたリバーストランスレーション研究が精力的になされ，耐性機序や治療効果が期待できる患者を選択できるバイオマーカーが徐々に解明されるとともに，新たな併用療法への開発が進んできた。本稿ではがん免疫の基礎を踏まえつつ，免疫チェックポイント阻害剤耐性機序の解明とその克服に向けた最近の知見を概説する。</p>

DOI： 10.11406/rinketsu.60.1341

PubMed

Comparison of the tube test and column agglutination techniques for anti-A/-B antibody titration in healthy individuals. 査読有り国際誌

Matsuura H, Akatsuka Y, Matsuno T, Sugiura Y, Arakawa S, Oikawa S, Yoshida J, Kosugi M, Emi N

Vox sanguinis 113 巻 ( 8 ) 頁： 787 - 794 2018年11月

Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.

Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H

Blood 132 巻 ( 11 ) 頁： 1134 - 1145 2018年9月

Rearrangement of VPS13B, a causative gene of Cohen syndrome, in a case of RUNX1–RUNX1T1 leukemia with t(8;12;21) 査読有り国際誌

Akihiro Abe, Yukiya Yamamoto, Akira Katsumi, Akinao Okamoto, Masutaka Tokuda, Yoko Inaguma, Kiyoko Yamamoto, Masamitsu Yanada, Tadaharu Kanie, Akihiro Tomita, Yoshiki Akatsuka, Masataka Okamoto, Toshiki Kameyama, Akila Mayeda, Nobuhiko Emi

International Journal of Hematology 108 巻 ( 2 ) 頁： 208 - 212 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2017, The Japanese Society of Hematology. Variant chromosomal translocations associated with t(8;21) are observed in 3–4% of acute myeloid leukemia (AML) cases with a RUNX1–RUNX1T1 fusion gene. However, the molecular events that occur in variants of t(8;21) are not well characterized. In the present study, we report genetic features of a variant three-way translocation of t(8;12;21)(q22;p11;q22) in a patient with AML. In this patient, leukemia cells lacked azurophilic granules, which does not correspond with the classic features of t(8;21). RNA-seq analysis revealed that TM7SF3 at 12p11 was fused to VPS13B at 8q22 and VPS13B to RUNX1, in addition to RUNX1–RUNX1T1. VPS13B was located near RUNX1T1 and both were localized at the same chromosomal bands. The reading frames of TM7SF3 and VPS13B did not match to those of VPS13B and RUNX1, respectively. Disruption of VPS13B causes Cohen syndrome, which presents intermittent neutropenia with a left-shifted granulopoiesis in the bone marrow. Disruption of VPS13B may thus cause the unusual features of RUNX1–RUNX1T1 leukemia. Our case indicates that rearrangement of VPS13B may be additional genetic events in variant t(8;21).

DOI： 10.1007/s12185-017-2387-x

Scopus

PubMed

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack. 査読有り国際誌

Espinoza JL, Elbadry MI, Chonabayashi K, Yoshida Y, Katagiri T, Harada K, Nakagawa N, Zaimoku Y, Imi T, Hassanein HA, Khalifa A Noreldin A, Takenaka K, Akashi K, Hamana H, Kishi H, Akatsuka Y, Nakao S

Blood advances 2 巻 ( 4 ) 頁： 390 - 400 2018年2月

Successful treatment with allogeneic stem cell transplantation followed by DLI and TKIs for e6a2 BCR-ABL-positive acute myeloid leukaemia A case report and literature review 査読有り国際誌

Harada Yasuhiko, Nishiwaki Satoshi, Sugimoto Takumi, Onodera Koichi, Goto Tatsunori, Sato Takahiko, Kamoshita Sonoko, Kawashima Naomi, Seto Aika, Okuno Shingo, Yamamoto Satomi, Iwasaki Toshihiro, Ozawa Yukiyasu, Miyamura Koichi, Akatsuka Yoshiki, Sugiura Isamu

MEDICINE 96 巻 ( 50 ) 頁： e9160 2017年12月

Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS 査読有り国際誌

Tawara Isao, Kageyama Shinichi, Miyahara Yoshihiro, Fujiwara Hiroshi, Nishida Tetsuya, Akatsuka Yoshiki, Ikeda Hiroaki, Tanimoto Kazushi, Terakura Seitaro, Murata Makoto, Inaguma Yoko, Masuya Masahiro, Inoue Naoki, Kidokoro Tomohide, Okamoto Sachiko, Tomura Daisuke, Chono Hideto, Nukaya Ikuei, Mineno Junichi, Naoe Tomoki, Emi Nobuhiko, Yasukawa Masaki, Katayama Naoyuki, Shiku Hiroshi

BLOOD 130 巻 ( 18 ) 頁： 1985 - 1994 2017年11月

The prognostic significance of EBV DNA load and EBER status in diagnostic specimens from diffuse large B-cell lymphoma patients 査読有り国際誌

Okamoto Akinao, Yanada Masamitsu, Inaguma Yoko, Tokuda Masutaka, Morishima Satoko, Kanie Tadaharu, Yamamoto Yukiya, Mizuta Shuichi, Akatsuka Yoshiki, Yoshikawa Tetsushi, Mizoguchi Yoshikazu, Nakamura Shigeo, Okamoto Masataka, Emi Nobuhiko

HEMATOLOGICAL ONCOLOGY 35 巻 ( 1 ) 頁： 87 - 93 2017年3月

Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. 査読有り

Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S

Nature 534 巻 ( 7607 ) 頁： 402-406 2016年6月

TP53 mutations in older adults with acute myeloid leukemia. 査読有り

Yanada M, Yamamoto Y, Iba S, Okamoto A, Inaguma Y, Tokuda M, Morishima S, Kanie T, Mizuta S, Akatsuka Y, Okamoto M, Emi N

International journal of hematology 103 巻 ( 4 ) 頁： 429-435 2016年4月

ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9. 査読有り

Abe A, Yamamoto Y, Iba S, Kanie T, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Mizuta S, Akatsuka Y, Okamoto M, Kameyama T, Mayeda A, Emi N

Genes, chromosomes & cancer 55 巻 ( 3 ) 頁： 242-250 2016年3月

Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia. 査読有り

Inaguma Y, Akatsuka Y, Hosokawa K, Maruyama H, Okamoto A, Katagiri T, Shiraishi K, Murayama Y, Tsuzuki-Iba S, Mizutani Y, Nishii C, Yamamoto N, Demachi-Okamura A, Kuzushima K, Ogawa S, Emi N, Nakao S

British journal of haematology 172 巻 ( 1 ) 頁： 131-134 2016年1月

Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation. 査読有り

Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, Ogawa S, Japan Marrow Donor Program.

Blood 126 巻 ( 25 ) 頁： 2752-2763 2015年12月

Prognostic significance of Epstein-Barr virus DNA detection in pretreatment serum in diffuse large B-cell lymphoma. 査読有り

Okamoto A, Yanada M, Miura H, Inaguma Y, Tokuda M, Morishima S, Kanie T, Yamamoto Y, Mizuta S, Akatsuka Y, Yoshikawa T, Mizoguchi Y, Nakamura S, Okamoto M, Emi N

Cancer science 106 巻 ( 11 ) 頁： 1576-1581 2015年11月

The fate of patients with acute myeloid leukemia not undergoing induction chemotherapy. 査読有り

Yanada M, Okamoto A, Inaguma Y, Tokuda M, Morishima S, Kanie T, Yamamoto Y, Mizuta S, Akatsuka Y, Okamoto M, Emi N

International journal of hematology 102 巻 ( 1 ) 頁： 35-40 2015年7月

Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells. 査読有り

Zhang R, Liu TY, Senju S, Haruta M, Hirosawa N, Suzuki M, Tatsumi M, Ueda N, Maki H, Nakatsuka R, Matsuoka Y, Sasaki Y, Tsuzuki S, Nakanishi H, Araki R, Abe M, Akatsuka Y, Sakamoto Y, Sonoda Y, Nishimura Y, Kuzushima K, Uemura Y

Cancer immunology research 3 巻 ( 6 ) 頁： 668-677 2015年6月

NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214. 査読有り

Abe A, Yamamoto Y, Iba S, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Kanie T, Tsuzuki M, Akatsuka Y, Mizuta S, Okamoto M, Kameyama T, Mayeda A, Emi N

Cytogenetic and genome research 146 巻 ( 4 ) 頁： 279-284 2015年

Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury. 査読有り

Asai H, Fujiwara H, Kitazawa S, Kobayashi N, Ochi T, Miyazaki Y, Ochi F, Akatsuka Y, Okamoto S, Mineno J, Kuzushima K, Ikeda H, Shiku H, Yasukawa M

Journal of hematology & oncology 7 巻頁： 3 2014年1月

An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules. 査読有り

Kondo S, Demachi-Okamura A, Hirosawa T, Maki H, Fujita M, Uemura Y, Akatsuka Y, Yamamoto E, Shibata K, Ino K, Kikkawa F, Kuzushima K

Human immunology 74 巻頁： 1103-1110 2013年9月

Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor. 査読有り

Tamanaka T, Oka Y, Fujiki F, Tsuboi A, Katsuhara A, Nakajima H, Hosen N, Nishida S, Lin YH, Tachino S, Akatsuka Y, Kuzushima K, Oji Y, Kumanogoh A, Sugiyama H

Anticancer research 32 巻頁： 5201-5209 2012年12月

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. 査読有り

Ochsenreither S, Majeti R, Schmitt T, Stirewalt D, Keilholz U, Loeb KR, Wood B, Choi YE, Bleakley M, Warren EH, Hudecek M, Akatsuka Y, Weissman IL, Greenberg PD

Blood 119 巻頁： 5492-5501 2012年6月

Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling. 査読有り

Yamamoto Y, Tsuzuki S, Akahori Y, Ukai Y, Sumitomo M, Murayama Y, Yamamoto K, Inaguma Y, Tokuda M, Abe A, Akatsuka Y, Emi N, Kurosawa Y

Cancer science 103 巻頁： 350-359 2012年2月

Autophagy creates a CTL epitope that mimics tumor-associated antigens. 査読有り

Demachi-Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K

PloS one 7 巻頁： e47126 2012年

HLA-C matching status does not affect rituximab-mediated antibody-dependent cellular cytotoxicity by allogeneic natural killer Cells. 査読有り

Machino T, Okoshi Y, Miyake Y, Akatsuka Y, Chiba S

Immunological investigations 41 巻頁： 831-846 2012年

Glypican-3 could be an effective target for immunotherapy combined with chemotherapy against ovarian clear cell carcinoma. 査読有り

Suzuki S, Yoshikawa T, Hirosawa T, Shibata K, Kikkawa F, Akatsuka Y, Nakatsura T

Cancer science 102 巻頁： 1622-1629 2011年9月

Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis. 査読有り

An J, Fujiwara H, Suemori K, Niiya T, Azuma T, Tanimoto K, Ochi T, Akatsuka Y, Mineno J, Ozawa H, Ishikawa F, Kuzushima K, Yasukawa M

International journal of hematology 93 巻頁： 176-185 2011年2月

The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene. 査読有り

Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T

PloS one 5 巻頁： e11901 2010年7月

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. 査読有り

Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR

Blood 115 巻頁： 3869-3878 2010年5月

Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation. 査読有り

Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S

Blood 115 巻 ( 15 ) 頁： 3158-3161 2010年4月

Frequent inactivation of A20 in B-cell lymphomas. 査読有り

Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S

Nature 459 巻頁： 712-716 2009年6月

Exploration of the genetic basis of GVHD by genetic association studies. 査読有り

Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E, Inoko H, Morishima Y, Kodera Y, Takehiko S, Japan Marrow Donation Program (JMDP)

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 15 巻頁： 39-41 2009年1月

CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy. 査読有り

Watanabe K, Suzuki S, Kamei M, Toji S, Kawase T, Takahashi T, Kuzushima K, Akatsuka Y

International journal of hematology 88 巻頁： 311-320 2008年10月

Epstein-Barr virus nuclear antigen 1-specific CD4+ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells. 査読有り

Demachi-Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K

Cancer science 99 巻頁： 1633-1642 2008年8月

Identification of a human leukocyte antigen-A24-restricted T-cell epitope derived from interleukin-13 receptor alpha2 chain, a glioma-associated antigen. 査読有り

Shimato S, Natsume A, Wakabayashi T, Tsujimura K, Nakahara N, Ishii J, Ito M, Akatsuka Y, Kuzushima K, Yoshida J

Journal of neurosurgery 109 巻頁： 117-122 2008年7月

CD16+ CD56- NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect. 査読有り

Lu X, Kondo Y, Takamatsu H, Ohata K, Yamazaki H, Takami A, Akatsuka Y, Nakao S

European journal of haematology 81 巻頁： 18-25 2008年7月

Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation. 査読有り

Torikai H, Akatsuka Y, Yatabe Y, Morishima Y, Kodera Y, Kuzushima K, Takahashi T

International journal of hematology 87 巻頁： 467-473 2008年6月

DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. 査読有り

Rosinski KV, Fujii N, Mito JK, Koo KK, Xuereb SM, Sala-Torra O, Gibbs JS, Radich JP, Akatsuka Y, Van den Eynde BJ, Riddell SR, Warren EH

Blood 111 巻頁： 4817-4826 2008年5月

Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions. 査読有り

Akatsuka Y, Morishima Y, Kuzushima K, Kodera Y, Takahashi T

Cancer science 98 巻頁： 1139-1146 2007年8月

Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells. 査読有り

Ito Y, Demachi-Okamura A, Ohta R, Akatsuka Y, Nishida K, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K

The Journal of general virology 88 巻頁： 770-780 2007年3月

Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. 査読有り

Morishima Y, Yabe T, Matsuo K, Kashiwase K, Inoko H, Saji H, Yamamoto K, Maruya E, Akatsuka Y, Onizuka M, Sakamaki H, Sao H, Ogawa S, Kato S, Juji T, Sasazuki T, Kodera Y, Japan Marrow Donor Program

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 13 巻頁： 315-328 2007年3月

Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-gamma on the presentation of a cryptic epitope. 査読有り

Morishima S, Akatsuka Y, Nawa A, Kondo E, Kiyono T, Torikai H, Nakanishi T, Ito Y, Tsujimura K, Iwata K, Ito K, Kodera Y, Morishima Y, Kuzushima K, Takahashi T

International journal of cancer. Journal international du cancer 120 巻頁： 594-604 2007年2月

Bone marrow may be a reservoir of long-lived memory T cells specific for minor histocompatibility antigen. 査読有り

Akatsuka Y, Torikai H, Inamoto Y, Tsujimura K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T

British journal of haematology 135 巻頁： 413-414 2006年11月

Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells. 査読有り

Naota H, Miyahara Y, Okumura S, Kuzushima K, Akatsuka Y, Hiasa A, Kitano S, Takahashi T, Yuta A, Majima Y, Shiku H

Journal of immunological methods 314 巻頁： 54-66 2006年7月

Characterization of murine CD160+ CD8+ T lymphocytes. 査読有り

Tsujimura K, Obata Y, Matsudaira Y, Nishida K, Akatsuka Y, Ito Y, Demachi-Okamura A, Kuzushima K, Takahashi T

Immunology letters 106 巻頁： 48-56 2006年7月

Epstein-Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies. 査読有り

Demachi-Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K

European journal of immunology 36 巻頁： 593-602 2006年3月

Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation. 査読有り

Ito Y, Kondo E, Demachi-Okamura A, Akatsuka Y, Tsujimura K, Tanimoto M, Morishima Y, Takahashi T, Kuzushima K

Journal of virology 80 巻頁： 883-890 2006年1月

A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation. 査読有り

Terakura S, Murata M, Nishida T, Emi N, Akatsuka Y, Riddell SR, Morishima Y, Kodera Y, Naoe T

British journal of haematology 129 巻頁： 221-228 2005年4月

Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases). 査読有り

Storek J, Zhao Z, Lin E, Berger T, McSweeney PA, Nash RA, Akatsuka Y, Metcalf MD, Lu H, Kalina T, Reindl M, Storb R, Hansen JA, Sullivan KM, Kraft GH, Furst DE, Maloney DG

Clinical immunology (Orlando, Fla.) 113 巻頁： 285-298 2004年12月

The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma. 査読有り

Ishida T, Iida S, Akatsuka Y, Ishii T, Miyazaki M, Komatsu H, Inagaki H, Okada N, Fujita T, Shitara K, Akinaga S, Takahashi T, Utsunomiya A, Ueda R

Clinical cancer research : an official journal of the American Association for Cancer Research 10 巻頁： 7529-7539 2004年11月

Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea. 査読有り

Tsujimura K, Obata Y, Matsudaira Y, Ozeki S, Taguchi O, Nishida K, Okanami Y, Akatsuka Y, Kuzushima K, Takahashi T

Cancer science 95 巻頁： 914-919 2004年11月

Interferon-gamma differentially regulates susceptibility of lung cancer cells to telomerase-specific cytotoxic T lymphocytes. 査読有り

Tajima K, Ito Y, Demachi A, Nishida K, Akatsuka Y, Tsujimura K, Hida T, Morishima Y, Kuwano H, Mitsudomi T, Takahashi T, Kuzushima K

International journal of cancer. Journal international du cancer 110 巻頁： 403-412 2004年6月

Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant. 査読有り

Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T

British journal of haematology 124 巻頁： 629-635 2004年3月

Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles. 査読有り

Kondo E, Akatsuka Y, Kuzushima K, Tsujimura K, Asakura S, Tajima K, Kagami Y, Kodera Y, Tanimoto M, Morishima Y, Takahashi T

Blood 103 巻頁： 630-638 2004年1月

Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling. 査読有り

Akatsuka Y, Warren EH, Gooley TA, Brickner AG, Lin MT, Hansen JA, Martin PJ, Madtes DK, Engelhard VH, Takahashi T, Riddell SR

British journal of haematology 123 巻頁： 671-675 2003年11月

Thymus leukemia antigen (TL)-specific cytotoxic T lymphocytes recognize the alpha1/alpha2 domain of TL free from antigenic peptides. 査読有り

Tsujimura K, Obata Y, Kondo E, Nishida K, Matsudaira Y, Akatsuka Y, Kuzushima K, Takahashi T

International immunology 15 巻頁： 1319-1326 2003年11月

Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. 査読有り

Topp MS, Riddell SR, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD

The Journal of experimental medicine 198 巻頁： 947-955 2003年9月

Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells. 査読有り

Miyazaki M, Akatsuka Y, Nishida T, Fujii N, Hiraki A, Ikeda K, Tsujimura K, Kuzushima K, Morishima Y, Sato S, Ueda R, Takahashi T

Clinical immunology (Orlando, Fla.) 107 巻頁： 198-201 2003年6月

Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. 査読有り

Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T

The Journal of experimental medicine 197 巻頁： 1489-1500 2003年6月

Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells. 査読有り

Kuzushima K, Hayashi N, Kudoh A, Akatsuka Y, Tsujimura K, Morishima Y, Tsurumi T

Blood 101 巻頁： 1460-1468 2003年2月

Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest. 査読有り

Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T

Transplantation 74 巻頁： 1773-1780 2002年12月

Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response. 査読有り

Mutimer HP, Akatsuka Y, Manley T, Chuang EL, Boeckh M, Harrington R, Jones T, Riddell SR

The Journal of infectious diseases 186 巻頁： 701-705 2002年9月

Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells. 査読有り

Kondo E, Topp MS, Kiem HP, Obata Y, Morishima Y, Kuzushima K, Tanimoto M, Harada M, Takahashi T, Akatsuka Y

Journal of immunology (Baltimore, Md. : 1950) 169 巻頁： 2164-2171 2002年8月

Determination of intronic sequences adjacent to an exon using polymerase chain reaction and genomic DNA library constructed by TA cloning. 査読有り

Akatsuka Y, Warren EH, Brickner AG, Engelhard VH, Riddell SR

Analytical biochemistry 289 巻頁： 289-292 2001年2月

Generation of HLA-C-specific cytotoxic T cells in association with marrow graft rejection: analysis of alloimmunity by T-cell cloning and testing of T-cell-receptor rearrangements. 査読有り

Pei J, Akatsuka Y, Anasetti C, Lin MT, Petersdorf EW, Hansen JA, Martin PJ

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 7 巻頁： 378-383 2001年

Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation. 査読有り

Lin MT, Tseng LH, Frangoul H, Gooley T, Pei J, Barsoukov A, Akatsuka Y, Hansen JA

Blood 95 巻頁： 3832-3839 2000年6月

Immunotherapy of human viral and malignant diseases with genetically modified T-cell clones. 査読有り

Riddell SR, Warren EH, Gavin MA, Akatsuka Y, Lewinsohn D, Mutimer H, Cooper L, Topp MS, Bonini C, Greenberg PD

Cancer journal (Sudbury, Mass.) 6 Suppl 3 巻頁： S250-8 2000年5月

A novel minor histocompatibility antigen recognized by HLA-A31 restricted cytotoxic T lymphocytes generated from HLA-identical bone marrow donor lymphocytes. 査読有り

Yazaki M, Takahashi T, Andho M, Akatsuka Y, Ito T, Miyake Y, Ito Y, Nakamura S, Wada Y

Bone marrow transplantation 24 巻頁： 129-137 1999年7月

Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells. 査読有り

Zhu L, Yu X, Akatsuka Y, Cooper JA, Anasetti C

Immunology 97 巻頁： 26-35 1999年5月

Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition. 査読有り

Akatsuka Y, Martin EG, Madonik A, Barsoukov AA, Hansen JA

Tissue antigens 53 巻頁： 122-134 1999年2月

Immune response of post-transplant peripheral lymphocytes against the patient pre-B cell line, NAGL-1. 査読有り

Kasai M, Akatsuka Y, Emi N, Taji H, Kohno A, Abe A, Tanimoto M, Kodera Y, Saito H

International journal of hematology 69 巻 ( 2 ) 頁： 112-118 1999年2月

Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection. 査読有り

Martin PJ, Akatsuka Y, Hahne M, Sale G

Blood 92 巻 ( 6 ) 頁： 2177-2181 1998年9月

Prolonged selective neutropenia after allogeneic bone marrow transplantation: possible effect of presensitization by donor lymphocytes prior to transplant. 査読有り

Towatari M, Miyamura K, Akatsuka Y, Yamamoto K, Minami S, Kodera Y

International journal of hematology 66 巻 ( 4 ) 頁： 513-516 1997年12月

T cell receptor clonal diversity following allogeneic marrow grafting. 査読有り

Akatsuka Y, Cerveny C, Hansen JA

Human immunology 48 巻 ( 1/2 ) 頁： 125-134 1996年6月

Retrovirus-mediated transfer of a hygromycin phosphotransferase-thymidine kinase fusion gene into human CD34+ bone marrow cells. 査読有り

Akatsuka Y, Emi N, Kato H, Abe A, Tanimoto M, Lupton SD, Saito H

International journal of hematology 60 巻 ( 4 ) 頁： 251-261 1994年12月

Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia. 査読有り

Kubo K, Naoe T, Kiyoi H, Fukutani H, Kato Y, Oguri T, Yamamori S, Akatsuka Y, Kodera Y, Ohno R

Japanese journal of cancer research : Gann 84 巻 ( 4 ) 頁： 379-387 1993年4月

Acute renal failure and degenerative tubular lesions associated with in situ formation of adenovirus immune complexes in a patient with allogeneic bone marrow transplantation. 査読有り

Yuzawa Y, Aoi N, Fukatsu A, Ichida S, Yoshida F, Akatsuka Y, Minami S, Kodera Y, Matsuo S

Transplantation 55 巻 ( 1 ) 頁： 67-72 1993年1月

Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor. Nagoya Bone Marrow Transplantation Group (NBMTG), Tokai Marrow Donor Bank (TMDB). 査読有り

Akatsuka Y, Kodera Y, Yamamoto K, Minami S, Miyamura K, Morishita Y, Morishima Y, Saitoh H, Horibe K, Yamauchi T

International journal of hematology 55 巻 ( 3 ) 頁： 249-253 1992年6月

Detection of Philadelphia chromosome-positive acute lymphoblastic leukemia by polymerase chain reaction: possible eradication of minimal residual disease by marrow transplantation. 査読有り

Miyamura K, Tanimoto M, Morishima Y, Horibe K, Yamamoto K, Akatsuka M, Kodera Y, Kojima S, Matsuyama K, Hirabayashi N

Blood 79 巻頁： 1366-1370 1992年3月

Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats. 査読有り

Matuo Y, Nishi N, Tanaka Y, Muguruma Y, Tanaka K, Akatsuka Y, Matsui SI, Sandberg AA, Wada F

Biochemical and biophysical research communications 118 巻 ( 2 ) 頁： 467-473 1984年1月

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<赤塚 美樹>

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