Faculty Profiles - MATSUYAMA Shuichi

Papers - MATSUYAMA Shuichi

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ウシにおける心拍変動解析を用いた環境ストレスの評価

森田康広, 向山晃永, 佐々木拓弥, 尾崎理穂, 舘林亮輝, 北川悠梨, 森島愛, 阿部良哉, 鈴村玲香, 松山秀一, 大蔵聡

日本畜産学会大会講演要旨集 Vol. 125回 page： 192 - 192 2019.3

ヤギのGnRHパルス生成活性に対するカルシトニン受容体シグナル伝達の役割(The role of calcitonin receptor signaling on the GnRH pulse generator activity in goats)

北川悠梨, 佐々木拓弥, 森島愛, 舘林亮輝, 森田康広, 松山秀一, 井上直子, 上野山賀久, 束村博子, 大蔵聡

日本畜産学会大会講演要旨集 Vol. 125回 page： 124 - 124 2019.3

Hori K, Matsuyama S, Nakamura S, Iwata H, Kuwayama T, Miyamoto A, Shirasuna K

Reproduction in domestic animals = Zuchthygiene Vol. 54 ( 1 ) page： 23 - 30 2019.1

Propionate and butyrate induce gene expression of monocarboxylate transporter 4 (MCT4) and cluster of differentiation 147 (CD147) in cultured rumen epithelial cells derived from pre-weaning dairy calves Reviewed International journal

Sho Nakamura, Satoshi Haga, Koji Kimura, Shuichi Matsuyama

Journal of Animal Science Vol. 96 ( 11 ) page： 4902 - 4911 2018.11

Authorship：Last author,　Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)

Short-chain fatty acids (SCFAs) are the main source of energy for postweaning ruminants. The monocarboxylic acid transporters, MCT1 and MCT4, are thought to contribute to the absorption of SCFAs from the surface of the rumen following weaning. The present study measured changes in MCT1 and MCT4 expression in ruminal epithelial cells isolated from male preweaning (22 to 34 d old, n = 6) and postweaning (55 to 58 d old, n = 8) calves after euthanasia and sought to examine whether SCFAs stimulate the expression of these transporters. In the current study, cluster of differentiation 147 (CD147) gene expression in the rumen was also investigated since CD147 has been considered to act as ancillary protein for MCT1 and MCT4 to express their correct function. The gene expression levels of MCT1, MCT4, and CD147 in the rumen were found to be significantly higher in postweaning calves than in preweaning calves. Strong MCT1 immunoreactivity was detected in both the stratum basale (SB) and the stratum spinosum (SS) in postweaning ruminal epithelium. Expression of MCT1 in preweaning calves was localized to a specific region of the SB and of the SS. MCT4-immunopositive cells were detected in the stratum corneum (SC) of the ruminal epithelium in postweaning calves. However, only a low level of signal was detected in the SC of preweaning animals. Furthermore, in vitro experiments, ruminal epithelial cells were incubated for 24 h with acetate (0.04, 0.4, and 4 mM), propionate (0.2, 2, and 20 mM), butyrate (0.1, 1, and 10 mM), or β-hydroxybutyrate (BHBA; 0.1, 1, and 10 mM), respectively. Both propionate and butyrate induced an increase in the gene expression levels of MCT4 and CD147, but did not affect MCT1 gene expression. There are no significant effects of acetate and BHBA treatment on these gene expressions. Taken together, these results suggest that an increase in MCT4 and CD147 gene expression in the ruminal epithelium of postweaning calves is likely to be due to the effects of propionate and butyrate derived from a solid-based diet, which may contribute to ruminal development following weaning.

DOI： 10.1093/jas/sky334

Web of Science

Scopus

PubMed

Publisher Correction: Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle. Reviewed

Ikeda M, Matsuyama S, Akagi S, Ohkoshi K, Nakamura S, Minabe S, Kimura K, Hosoe M

Scientific reports Vol. 8 ( 1 ) page： 1470 2018.1

Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle Reviewed

Mitsumi Ikeda, Shuichi Matsuyama, Satoshi Akagi, Katsuhiro Ohkoshi, Sho Nakamura, Shiori Minabe, Koji Kimura, Misa Hosoe

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 17827 2017.12

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Isoleucyl-tRNA synthetase (IARS) syndrome is a recessive disease of Japanese Black cattle caused by a single nucleotide substitution. To repair the mutated IARS gene, we designed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) to create a double-strand break near the mutation site. CRISPR/Cas9 and donor DNA that contained a synonymous codon for the correct amino acid and an Aequorea coerulescens Green Fluorescent Protein (AcGFP) cassette with a piggyBac transposase recognition site at both ends were introduced into bovine fetal fibroblast (BFF) cells isolated from a homozygous mutant calf. Recombinant cells were enriched on the basis of expression of AcGFP, and two cell lines that contained the repaired allele were subcloned. We generated somatic cell nuclear transfer (SCNT) embryos from the repaired cells and transferred 22 blastocysts to recipient cows. In total, five viable fetuses were retrieved at Days 34 and 36. PiggyBac transposase mRNA was introduced into BFF cells isolated from cloned foetuses and AcGFP-negative cells were used for second round of cloning. We transferred nine SCNT embryos to recipient cows and retrieved two fetuses at Day 34. Fetal genomic DNA analysis showed correct repair of the IARS mutation without any additional DNA footprint.

DOI： 10.1038/s41598-017-17968-w

Web of Science

PubMed

Production of calves by the transfer of cryopreserved bovine elongating conceptuses and possible application for preimplantation genomic selection Reviewed

Takashi Fujii, Hiroki Hirayama, Akira Naito, Masashi Kashima, Hitomi Sakai, Shigeo Fukuda, Hitomi Yoshino, Satoru Moriyasu, Soichi Kageyama, Yoshikazu Sugimoto, Shuichi Matsuyama, Hiroyuki Hayakawa, Koji Kimura

JOURNAL OF REPRODUCTION AND DEVELOPMENT Vol. 63 ( 5 ) page： 497 - 504 2017.10

Language：English Publishing type：Research paper (scientific journal) Publisher：SOCIETY REPRODUCTION & DEVELOPMENT-SRD

Preimplantation genomic selection based on single nucleotide polymorphism (SNP) genotypes is expected to accelerate genetic improvement in cattle. However, genome-wide genotyping at the early embryonic stage has several limitations, such as the technical difficulty of embryonic biopsy and low accuracy of genotyping resulting from a limited number of biopsied cells. After hatching from the zona pellucida, the morphology of the bovine embryo changes from spherical to filamentous, in a process known as elongation. The bovine nonsurgical elongating conceptus transfer technique was recently developed and applied for sexing without requiring specialized skills for biopsy. In order to develop a bovine preimplantation genomic selection system combined with the elongating conceptus transfer technique, we examined the accuracy of genotyping by SNP chip analysis using the DNA from elongating conceptuses (Experiment 1) and optimal cryopreservation methods for elongating conceptuses (Experiment 2). In Experiment 1, the call rates of SNP chip analysis following whole genome amplification in biopsied cells from two elongating conceptuses were 95.14% and 99.32%, which were sufficient for estimating genomic breeding value. In Experiment 2, the rates of dead cells in elongating conceptuses cryopreserved by slow freezing were comparable to those in fresh elongating conceptuses. In addition, we obtained healthy calves by the transfer of elongating conceptuses cryopreserved by slow freezing. Our findings indicate that the elongating conceptus transfer technology enables preimplantation genomic selection in cattle based on SNP chip analysis. Further studies on the optimization of cryopreservation methods for elongating conceptuses are required for practical application of the selection system.

DOI： 10.1262/jrd.2017-025

Web of Science

PubMed

Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line Reviewed

Nao Tanikawa, Kotomi Seno, Ryouka Kawahara-Miki, Koji Kimura, Shuichi Matsuyama, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH Vol. 37 ( 10 ) page： 456 - 466 2017.10

Language：English Publishing type：Research paper (scientific journal) Publisher：MARY ANN LIEBERT, INC

Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on human trophoblast cell functions. First, we performed next-generation sequencing and demonstrated that IFNT-dependent changes in the human Sw.71 trophoblast cell line are partly mediated by proinflammatory as well as IFN signaling. Next, we validated candidate genes, and data confirmed that IFNT stimulated interleukin-6 (IL-6) and IL-8 mRNA expression and secretion. However, human IFNB did not affect IL-6 and IL-8 mRNA expression and secretion. IFNT-induced cytokine secretion was dependent on STAT3 signaling, but not STAT1 signaling. In addition, treatment with IFNT, IL-6, or IL-8 increased cell proliferation, and IFNT also stimulated cell migration in human trophoblast cells. Although IFNT did not affect superoxide dismutase (SOD) 1 mRNA expression, it clearly increased mitochondrial SOD2 mRNA expression, resulting in the acceleration of SOD activity. We demonstrated that in addition to IFN signaling, IFNT also regulated inflammation-related signaling as well as cell proliferation, migration, and redox signaling in human trophoblast cells.

DOI： 10.1089/jir.2017.0057

Web of Science

PubMed

Age-associated mRNA expression changes in bovine endometrial cells in vitro Reviewed

Nao Tanikawa, Ayaka Ohtsu, Ryouka Kawahara-Miki, Koji Kimura, Shuichi Matsuyama, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY Vol. 15 ( 1 ) page： 63 2017.8

Language：English Publishing type：Research paper (scientific journal) Publisher：BIOMED CENTRAL LTD

Background: Endometrial cells secrete various cytokines and the dysfunction of endometrial cells may directly lead to infertility. Interferon tau (IFNT) secreted by trophoblast cells, a well-known pregnancy recognition signal in ruminants, acts on the uterus to prepare for pregnancy. Aging causes cellular and organ dysfunction, and advanced maternal age is associated with reduced fertility. However, few studies have investigated age-dependent changes in the uterus.
Methods: Using next generation sequencing and real-time PCR, we examined mRNA expression in bovine endometrial cells in vitro obtained from young (mean 45.2 months) and aged (mean 173.5 months) animals and the effects of IFNT depending on the age.
Results: We showed that inflammation-related (predicted molecules are IL1A, C1Qs, DDX58, NFKB, and CCL5) and interferon-signaling (predicted molecules are IRFs, IFITs, STATs, and IFNs) pathways were activated in endometrial cells obtained from aged compared to young cows. Also, the activation of "DNA damage checkpoint regulation" and the inhibition of "mitotic mechanisms" in endometrial cells obtained from aged cows were evident. Moreover, we showed lower cell viability levels in endometrial cells obtained from aged compared to young cows. Although treatment with IFNT upregulated various types of interferon stimulated genes both in endometrial cells obtained from young and aged cows, the rate of increase by IFNT stimulus was obviously lower in endometrial cells obtained from aged compared to young cows.
Conclusions: Endometrial cells obtained from aged cows exhibited higher levels of inflammatory- and IFN-signaling, and dysfunction of cell division compared with young cows. In addition, a high basal level of IFN-related genes in endometrial cells of aged cows is suggested a concept of "inflammaging".

DOI： 10.1186/s12958-017-0284-z

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PubMed

A neurokinin 3 receptor-selective agonist accelerates pulsatile luteinizing hormone secretion in lactating cattle Reviewed

Sho Nakamura, Yoshihiro Wakabayashi, Takashi Yamamura, Satoshi Ohkura, Shuichi Matsuyama

BIOLOGY OF REPRODUCTION Vol. 97 ( 1 ) page： 81 - 90 2017.7

Authorship：Last author,　Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS INC

Pulsatile gonadotropin-releasing hormone (GnRH) secretion, which is indispensable for follicular development, is suppressed in lactating dairy and beef cattle. Neurokinin B (NKB) neurons in the arcuate nucleus of the hypothalamus are considered to play an essential role in generating the pulsatile mode of GnRH/luteinizing hormone (LH) secretion. The present study aimed to clarify the role of NKB-neurokinin 3 receptor (NK3R) signaling in the pulsatile pattern of GnRH/gonadotropin secretion in postpartum lactating cattle. We examined the effects of the administration of an NK3R-selective agonist, senktide, on gonadotropin secretion in lactating cattle. The lactating cattle, at approximately 7 days postpartum, were intravenously infused with senktide (30 or 300 nmol/min) or vehicle for 24 h. The administration of 30 or 300 nmol/min senktide significantly increased LH pulse frequency compared to in the control group during 0-4 or 20-24 h after infusion, respectively. Moreover, LH and follicle-stimulating hormone levels were gradually increased by 300 nmol/min administration of senktide during the 0-4-h sampling period. Ultrasonography of the ovaries was performed to identify the first postpartum ovulation in senktide-administered lactating cattle. The interval from calving to first postpartum ovulation was significantly shorter in the 300 nmol/min senktide-administered group than in the control group. Taken together, these findings suggest that senktide infusion elicits an increase in LH pulse frequency that may stimulate follicular development and, in turn, induce the first postpartum ovulation in lactating cattle.
Summary Sentence
Administration of senktide, an NK3R-selective agonist, elicits an increase in LH pulse frequency that may stimulate follicular development and, in turn, induce the first postpartum ovulation in lactating cattle.

DOI： 10.1093/biolre/iox068

Web of Science

Scopus

PubMed

ウシの子宮機能と受胎性について Reviewed

木村康二、松山秀一

家畜感染症学会誌 Vol. 5 ( 4 ) page： 145 - 151 2016.12

Derivation of Induced Trophoblast Cell Lines in Cattle by Doxycycline-Inducible piggyBac Vectors Reviewed

Kawaguchi T, Cho D, Hayashi M, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M, Imai H.

PLoS ONE Vol. 11 ( 12 ) page： e0167550 2016.11

Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers. Reviewed

Hassaneen A, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, Inoue N, Uenoyama Y, Tsukamura H, Maeda K, Matsuda F, Ohkura S.

Journal of Reproduction and Development Vol. 62 ( 5 ) page： 471 - 477 2016.10

ウシにおける胚の生存性と子宮環境 Reviewed

松山秀一、中村翔、木村康二

日本胚移植学雑誌 Vol. 38 ( 3 ) page： 115 - 121 2016.9

Possible role of IFNT on the bovine corpus luteum and neutrophils during the early pregnancy. Reviewed

Shirasuna K, Matsumoto H, Matsuyama S, Kimura K, Bollwein H, Miyamoto A.

Reproduction Vol. 150 ( 3 ) page： 217 - 225 2015.9

Generation of Naive Bovine Induced Pluripotent Stem Cells Using PiggyBac Transposition of Doxycycline-Inducible Transcription Factors. Reviewed

Kawaguchi T, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M, Imai H.

PLoS ONE Vol. 10 ( 8 ) page： e0135403 2015.8

Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages. Reviewed

Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M.

PLoS ONE Vol. 9 ( 12 ) page： e113974 2014.12

Regulation of gonadotropin secretion by monitoring energy availability. Reviewed

Matsuyama S, Kimura K

Reproductive Medicine and Biology Vol. 14 ( 2 ) page： 39 - 47 2014.9

Successful nonsurgical transfer of bovine elongating conceptuses and its application to sexing. Reviewed

Kimura K Matsuyama S.

Journal of Reproduction and Development Vol. 60 ( 3 ) page： 210 - 215 2014.7

Aerococcus vaginalis sp. nov., isolated from the vaginal mucosa of a beef cow, and emended descriptions of Aerococcus suis, Aerococcus viridans, Aerococcus urinaeequi, Aerococcus urinaehominis, Aerococcus urinae, Aerococcus christensenii and Aerococcus sanguinicola. Reviewed

Tohno M, Kitahara M, Matsuyama S, Kimura K, Ohkura M, Tajima K.

International Journal of Systematic and Evolutionary Microbiology Vol. 64 page： 1229 - 1236 2014.4

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Papers - MATSUYAMA Shuichi