Updated on 2022/09/08

写真a

 
TANIGUCHI Tomoya
 
Organization
Nagoya University Hospital Anesthesiology Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. M.D. ( Nagoya University ) 

Research Interests 6

  1. Flexion reflex

  2. 神経生理学

  3. Central sensitization

  4. wind-up

  5. Temporal summation of pain

  6. NMDA受容体

Research Areas 4

  1. Life Science / Physiology

  2. Life Science / Anesthesiology

  3. Life Science / Anesthesiology

  4. Life Science / Neuroscience-general

Research History 3

  1. 名古屋大学 医学部附属病院   麻酔科   病院助教

    2018.4

  2. 小牧市民病院   麻酔科

    2017.4 - 2018.3

  3. 小牧市民病院   研修医

    2015.4 - 2017.3

Education 1

  1. Nagoya University

    2009.4 - 2015.3

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    Country: Japan

 

Papers 10

  1. A Minimally Invasive Method for Observing Wind-Up of Flexion Reflex in Humans: Comparison of Electrical and Magnetic Stimulation. Reviewed International journal

    Tomoya Taniguchi, Tomoaki Alex Kinukawa, Nobuyuki Takeuchi, Shunsuke Sugiyama, Makoto Nishihara, Kimitoshi Nishiwaki, Koji Inui

    Frontiers in neuroscience   Vol. 16   page: 837340 - 837340   2022.2

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    Wind-up like pain or temporal summation of pain is a phenomenon in which pain sensation is increased in a frequency-dependent manner by applying repeated noxious stimuli of uniform intensity. Temporal summation in humans has been studied by observing the increase in pain or flexion reflex by repetitive electrical or thermal stimulations. Nonetheless, because the measurement is accompanied by severe pain, a minimally invasive method is desirable. Gradual augmentation of flexion reflex and pain induced by repetitive stimulation of the sural nerve was observed using three stimulation methods-namely, bipolar electrical, magnetic, and monopolar electrical stimulation, with 11 healthy male subjects in each group. The effects of frequency, intensity, and number of repetitive stimuli on the increase in the magnitude of flexion reflex and pain rating were compared among the three methods. The reflex was measured using electromyography (EMG) from the short head of the biceps femoris. All three methods produced a frequency- and intensity-dependent progressive increase in reflex and pain; pain scores were significantly lower for magnetic and monopolar stimulations than for bipolar stimulation (P < 0.05). The slope of increase in the reflex was steep during the first 4-6 stimuli but became gentler thereafter. In the initial phase, an increase in the reflex during the time before signals of C-fibers arrived at the spinal cord was observed in experiments using high-frequency stimulation, suggesting that wind-up was caused by inputs of A-fibers without the involvement of C-fibers. Magnetic and monopolar stimulations are minimally invasive and useful methods for observing the wind-up of the flexion reflex in humans. Monopolar stimulation is convenient because it does not require special equipment. There is at least a partial mechanism underlying the wind-up of the flexion reflex that does not require C-fibers.

    DOI: 10.3389/fnins.2022.837340

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  2. Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation. International journal

    Shunsuke Sugiyama, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Kazutaka Ohi, Toshiki Shioiri, Makoto Nishihara, Koji Inui

    Cerebral cortex (New York, N.Y. : 1991)   Vol. 32 ( 13 ) page: 2785 - 2796   2022.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Gamma oscillations have received considerable attention owing to their association with cognitive function and various neuropsychiatric disorders. However, interactions of gamma oscillations at different frequency bands in humans remain unclear. In the present magnetoencephalographic study, brain oscillations in a wide frequency range were examined using a time-frequency analysis during the 20-, 30-, 40-, and 50-Hz auditory stimuli in 21 healthy subjects. First, dipoles for auditory steady-state response (ASSR) were estimated and interaction among oscillations at 10-60 Hz was examined using the source strength waveforms. Results showed the suppression of ongoing low-gamma oscillations at approximately 30 Hz during stimulation at 40 Hz. Second, multi-dipole analyses suggested that the main dipole for ASSR and dipoles for suppressed low-frequency gamma oscillations were distinct. Third, an all-sensor analysis was performed to clarify the distribution of the 40-Hz ASSR and suppression of low-frequency gamma oscillations. Notably, the area of suppression surrounded the center of the 40-Hz ASSR and showed a trend of extending to the vertex, indicating that different groups of neurons were responsible for these two gamma oscillations and that the 40-Hz oscillation circuit have specific inhibitory innervation to the low-gamma circuit.

    DOI: 10.1093/cercor/bhab381

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  3. Risk factors for postoperative sore throat associated with i-gel™, a supraglottic airway device. Reviewed

    Tomoya Taniguchi, Tasuku Fujii, Nanako Taniguchi, Kimitoshi Nishiwaki

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 319 - 326   2022.5

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    i-gel™ is a supraglottic airway device widely used for airway management during general anesthesia as an alternative to tracheal intubation. It sometimes results in a sore throat postoperatively; however, the risk factors for a postoperative sore throat caused by i-gel remain unclear. Here, we clarify the risk factors for a postoperative sore throat associated with i-gel insertion. We retrospectively reviewed the data of 426 adult patients who received general anesthesia with i-gel at our institution from January 2018 to December 2019. The incidence of postoperative sore throat and intraoperative data (size of i-gel, number of insertion attempts, total insertion time, and dose of the neuromuscular blocker and opioid) were evaluated. Logistic regression analysis was performed to identify the risk factors. Postoperative sore throat following i-gel insertion occurred in 24/426 patients (5.6%). The insertion time was significantly associated with the incidence of postoperative sore throat in the univariate analysis, but not in the multivariate analysis (P=0.519). Increased doses of neuromuscular blockers before i-gel insertion (odds ratio [OR], 5.46; 95% confidence interval [CI], 1.50-19.80; P=0.001) and reduced doses of intraoperative fentanyl (OR, 0.51; 95% CI, 0.28-0.93; P=0.028) were risk factors in the univariate and multivariate analyses. In the subgroup that used neuromuscular blockers before i-gel insertion, only an increased dose of neuromuscular blocker (OR, 17.2; 95%, CI 1.06-280; P=0.046) was an associated risk factor in the univariate and multivariate analyses. Overall, increased doses of neuromuscular blockers before i-gel insertion could contribute to the development of postoperative sore throat.

    DOI: 10.18999/nagjms.84.2.319

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  4. Mechanisms of Long-Latency Paired Pulse Suppression: MEG Study. International journal

    Nobuyuki Takeuchi, Kohei Fujita, Tomoya Taniguchi, Tomoaki Kinukawa, Shunsuke Sugiyama, Kousuke Kanemoto, Makoto Nishihara, Koji Inui

    Brain topography   Vol. 35 ( 2 ) page: 241 - 250   2022.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Paired pulse suppression is an electrophysiological method used to evaluate sensory suppression and often applied to patients with psychiatric disorders. However, it remains unclear whether the suppression comes from specific inhibitory mechanisms, refractoriness, or fatigue. In the present study, to investigate mechanisms of suppression induced by an auditory paired pulse paradigm in 19 healthy subjects, magnetoencephalography was employed. The control stimulus was a train of 25-ms pure tones of 65 dB SPL for 2500 ms. In order to evoke a test response, the sound pressure of two consecutive tones at 2200 ms in the control sound was increased to 80 dB (Test stimulus). Similar sound pressure changes were also inserted at 1000 (CS2) and 1600 (CS1) ms as conditioning stimuli. Four stimulus conditions were used; (1) Test alone, (2) Test + CS1, (3) Test + CS1 + CS2, and (4) Test + CS2, with the four sound stimuli randomly presented and cortical responses averaged at least 100 times for each condition. The baseline-to-peak and peak-to-peak amplitudes of the P50m, N100m, and P200m components of the test response were compared among the four conditions. In addition, the response to CS1 was compared between conditions (2) and (3). The results showed significant test response suppression by CS1. While the response to CS1 was significantly suppressed when CS2 was present, it did not affect suppression of the test response by CS1. It was thus suggested that the amplitude of the response to a conditioning stimulus is not a factor to determine the inhibitory effects of the test response, indicating that suppression is due to an external influence on the excitatory pathway.

    DOI: 10.1007/s10548-021-00878-6

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  5. 疼痛関連評価の現状と今後:どうすれば痛みを客観視できるのか 慢性疼痛の臨床応用に向けた生理学的評価の意義

    西原 真理, 絹川 友章, 谷口 智哉, 藤田 雄輝, 神谷 妙子, 柴田 由加, 竹内 伸行, 杉山 俊介, 藤田 貢平, 乾 幸二, 牛田 享宏

    臨床神経生理学   Vol. 49 ( 5 ) page: 313 - 313   2021.10

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    Language:Japanese   Publisher:(一社)日本臨床神経生理学会  

  6. 脳波計を用いた誘発電位とTCI、STAI、BFIによる性格形質

    竹内 伸行, 藤田 貢平, 谷口 智哉, 絹川 友章, 杉山 俊介, 兼本 浩祐, 乾 幸二, 西原 真理

    精神神経学雑誌   ( 2021特別号 ) page: S557 - S557   2021.9

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

  7. 脳波計を用いた誘発電位とTCI、STAI、BFIによる性格形質

    竹内 伸行, 藤田 貢平, 谷口 智哉, 絹川 友章, 杉山 俊介, 兼本 浩祐, 乾 幸二, 西原 真理

    精神神経学雑誌   ( 2021特別号 ) page: S557 - S557   2021.9

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

  8. Conditioned Pain Modulation: Comparison of the Effects on Nociceptive and Non-nociceptive Blink Reflex. International journal

    Tomoaki Alex Kinukawa, Koji Inui, Tomoya Taniguchi, Nobuyuki Takeuchi, Shunsuke Sugiyama, Makoto Nishihara, Kimitoshi Nishiwaki, Ryusuke Kakigi

    Neuroscience   Vol. 468   page: 168 - 175   2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Although conditioned pain modulation (CPM) is considered to represent descending pain inhibitory mechanisms triggered by noxious stimuli applied to a remote area, there have been no previous studies comparing CPM between pain and tactile systems. In this study, we compared CPM between the two systems objectively using blink reflexes. Intra-epidermal electrical stimulation (IES) and transcutaneous electrical stimulation (TS) were applied to the right skin area over the supraorbital foramen to evoke a nociceptive or a non-nociceptive blink reflex, respectively, in 15 healthy males. In the test session, IES or TS were applied six times and subjects reported the intensity of each stimulus on a numerical rating scale (NRS). Blink reflexes were measured using electromyography (R2). The first and second sessions were control sessions, while in the third session, the left hand was immersed in cold water at 10 °C as a conditioning stimulus. The magnitude of the R2 blink and NRS scores were compared among the sessions by 2-way ANOVA. Both the NRS score and nociceptive R2 were significantly decreased in the third session for IES, with a significant correlation between the two variables; whereas, TS-induced non-nociceptive R2 did not change among the sessions. Although the conditioning stimulus decreased the NRS score for TS, the CPM effect was significantly smaller than that for IES (p = 0.002). The present findings suggest the presence of a pain-specific CPM effect to a heterotopic noxious stimulus.

    DOI: 10.1016/j.neuroscience.2021.06.019

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  9. The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders. International journal

    Shunsuke Sugiyama, Kazutaka Ohi, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Eishi Motomura, Makoto Nishihara, Toshiki Shioiri, Koji Inui

    Frontiers in psychiatry   Vol. 12   page: 644541 - 644541   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Sensory processing is disrupted in several psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder. In this review, we focus on the electrophysiological auditory steady-state response (ASSR) driven by high-frequency stimulus trains as an index for disease-associated sensory processing deficits. The ASSR amplitude is suppressed within the gamma band (≥30 Hz) among these patients, suggesting an imbalance between GABAergic and N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission. The reduced power and synchronization of the 40-Hz ASSR are robust in patients with schizophrenia. In recent years, similar ASSR deficits at gamma frequencies have also been reported in patients with bipolar disorder and autism spectrum disorder. We summarize ASSR abnormalities in each of these psychiatric disorders and suggest that the observed commonalities reflect shared pathophysiological mechanisms. We reviewed studies on phase resetting in which a salient sensory stimulus affects ASSR. Phase resetting induces the reduction of both the amplitude and phase of ASSR. Moreover, phase resetting is also affected by rare auditory stimulus patterns or superimposed stimuli of other modalities. Thus, sensory memory and multisensory integration can be investigated using phase resetting of ASSR. Here, we propose that ASSR amplitude, phase, and resetting responses are sensitive indices for investigating sensory processing dysfunction in psychiatric disorders.

    DOI: 10.3389/fpsyt.2021.644541

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  10. 痛みの客観的な評価と臨床活用への挑戦 電気生理学的手法による痛みの評価

    西原 真理, 絹川 友章, 谷口 智哉, 柴田 由加, 乾 幸二, 牛田 享宏

    臨床神経生理学   Vol. 48 ( 5 ) page: 470 - 470   2020.10

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    Language:Japanese   Publisher:(一社)日本臨床神経生理学会  

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MISC 3

  1. 体外式除細動器が使用不能になった植込み型補助人工心臓HeartMate2による電磁干渉

    谷口智哉, 藤井祐, 谷口菜奈子, 尾関奏子, 西脇公俊

    Cardiovascular Anesthesia   Vol. 24 ( Suppl (CD-ROM) ) page: 176 - 176   2020

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    Language:Japanese   Publisher:(一社)日本心臓血管麻酔学会  

    J-GLOBAL

  2. 電気生理学的手法による痛みの評価

    西原真理, 絹川友章, 谷口智哉, 柴田由加, 乾幸二, 牛田享宏

    臨床神経生理学(Web)   Vol. 48 ( 5 )   2020

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  3. i-gelと気管挿管による術後口腔内合併症の比較

    谷口智哉, 二宮菜奈子, 西脇公俊

    日本麻酔科学会学術集会(Web)   Vol. 66th   2019

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Presentations 3

  1. 周術期高血糖に対して人工膵臓STG-55を用いて良好な血糖管理を得た1症例

    谷口 智哉、平井 昂宏、藤井 祐 、田村 高廣 、鈴木 章悟 、西脇 公俊

    日本集中治療学会第4回東海北陸支部学術集会 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  2. 体外式除細動器が使用不能になった植え込み型人工心臓HeartMate2による電磁干渉

    谷口 智哉、藤井 祐、谷口 菜奈子 、尾関 奏子、西脇 公俊

    日本心臓血管麻酔学会 第25回学術大会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  3. i-gelと気管挿管による術後口腔内合併症の比較

    谷口 智哉, 二宮 菜奈子, 西脇 公俊

    日本麻酔科学会 第66回学術集会 

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    Event date: 2019.5 - 2019.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan