Updated on 2024/05/07

写真a

 
TANIGUCHI Tomoya
 
Organization
Nagoya University Hospital Anesthesiology Assistant professor of hospital
Title
Assistant professor of hospital
Contact information
メールアドレス

Degree 1

  1. M.D. ( Nagoya University ) 

Research Interests 6

  1. Flexion reflex

  2. 神経生理学

  3. Central sensitization

  4. wind-up

  5. Temporal summation of pain

  6. NMDA受容体

Research Areas 4

  1. Life Science / Physiology

  2. Life Science / Anesthesiology

  3. Life Science / Anesthesiology

  4. Life Science / Neuroscience-general

Research History 3

  1. 名古屋大学 医学部附属病院   麻酔科   病院助教

    2018.4

  2. 小牧市民病院   麻酔科

    2017.4 - 2018.3

  3. 小牧市民病院   研修医

    2015.4 - 2017.3

Education 1

  1. Nagoya University

    2009.4 - 2015.3

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    Country: Japan

Awards 1

  1. 若手奨励賞(基礎研究)

    2023.5   日本麻酔科学会   「ヒトにおけるワインドアップ現象を観察し定量化する低侵襲な方法」

 

Papers 20

  1. Cortical activity during the wind-up of flexion reflex and pain: a magnetoencephalographic study using time-frequency analysis Reviewed International journal

    Tomoya Taniguchi, Tomoaki Alex Kinukawa, Nobuyuki Takeuchi, Shunsuke Sugiyama, Makoto Nishihara, Tetsuo Kida, Kimitoshi Nishiwaki, Koji Inui

    Cerebral Cortex   Vol. 33 ( 12 ) page: 7678 - 7687   2023.6

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    Wind-up is a nociceptive-specific phenomenon in which pain sensations are facilitated, in a frequency-dependent manner, by the repeated application of noxious stimuli of constant intensity, with invariant tactile sensations. Thus, cortical activities during wind-up could be an alteration associated with pain potentiation. We aimed to investigate somatosensory-evoked cortical responses and induced brain oscillations during wind-up by recording magnetoencephalograms. Wind-up was produced by the application of 11 consecutive electrical stimuli to the sural nerve, repeated at a frequency of 1 Hz without varying the intensity. The augmentation of flexion reflexes and pain rating scores were measured simultaneously as an index of wind-up. In the time-frequency analyses, the γ-band late event-related synchronization and the β-band event-related desynchronization were observed in the primary somatosensory region and the bilateral operculo-insular region, respectively. Repetitive exposure to the stimuli enhanced these activities, along with an increase in the flexion reflex magnitude. The evoked cortical activity reflected novelty, with no alteration to these repetitive stimuli. Observed oscillations enhanced by repetitive stimulation at a constant intensity could reflect a pain mechanism associated with wind-up.

    DOI: 10.1093/cercor/bhad071

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  2. Accuracy of a noninvasive estimated continuous cardiac output measurement under different respiratory conditions: a prospective observational study

    Takakura, M; Fujii, T; Taniguchi, T; Suzuki, S; Nishiwaki, K

    JOURNAL OF ANESTHESIA   Vol. 37 ( 3 ) page: 394 - 400   2023.6

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    Language:English   Publisher:Journal of Anesthesia  

    Purpose: The estimated continuous cardiac output (esCCO) system was recently developed as a noninvasive hemodynamic monitoring alternative to the thermodilution cardiac output (TDCO). However, the accuracy of continuous cardiac output measurements by the esCCO system compared to TDCO under different respiratory conditions remains unclear. This prospective study aimed to assess the clinical accuracy of the esCCO system by continuously measuring the esCCO and TDCO. Methods: Forty patients who had undergone cardiac surgery with a pulmonary artery catheter were enrolled. We compared the esCCO with TDCO from mechanical ventilation to spontaneous respiration through extubation. Patients undergoing cardiac pacing during esCCO measurement, those receiving treatment with an intra-aortic balloon pump, and those with measurement errors or missing data were excluded. In total, 23 patients were included. Agreement between the esCCO and TDCO measurements was evaluated using Bland–Altman analysis with a 20 min moving average of the esCCO. Results: The paired esCCO and TDCO measurements (939 points before extubation and 1112 points after extubation) were compared. The respective bias and standard deviation (SD) values were 0.13 L/min and 0.60 L/min before extubation, and − 0.48 L/min and 0.78 L/min after extubation. There was a significant difference in bias before and after extubation (P < 0.001); the SD before and after extubation was not significant (P = 0.315). The percentage errors were 25.1% before extubation and 29.6% after extubation, which is the criterion for acceptance of a new technique. Conclusion: The accuracy of the esCCO system is clinically acceptable to that of TDCO under mechanical ventilation and spontaneous respiration.

    DOI: 10.1007/s00540-023-03176-6

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  3. A Minimally Invasive Method for Observing Wind-Up of Flexion Reflex in Humans: Comparison of Electrical and Magnetic Stimulation. Reviewed International journal

    Tomoya Taniguchi, Tomoaki Alex Kinukawa, Nobuyuki Takeuchi, Shunsuke Sugiyama, Makoto Nishihara, Kimitoshi Nishiwaki, Koji Inui

    Frontiers in neuroscience   Vol. 16   page: 837340 - 837340   2022.2

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    Wind-up like pain or temporal summation of pain is a phenomenon in which pain sensation is increased in a frequency-dependent manner by applying repeated noxious stimuli of uniform intensity. Temporal summation in humans has been studied by observing the increase in pain or flexion reflex by repetitive electrical or thermal stimulations. Nonetheless, because the measurement is accompanied by severe pain, a minimally invasive method is desirable. Gradual augmentation of flexion reflex and pain induced by repetitive stimulation of the sural nerve was observed using three stimulation methods-namely, bipolar electrical, magnetic, and monopolar electrical stimulation, with 11 healthy male subjects in each group. The effects of frequency, intensity, and number of repetitive stimuli on the increase in the magnitude of flexion reflex and pain rating were compared among the three methods. The reflex was measured using electromyography (EMG) from the short head of the biceps femoris. All three methods produced a frequency- and intensity-dependent progressive increase in reflex and pain; pain scores were significantly lower for magnetic and monopolar stimulations than for bipolar stimulation (P < 0.05). The slope of increase in the reflex was steep during the first 4-6 stimuli but became gentler thereafter. In the initial phase, an increase in the reflex during the time before signals of C-fibers arrived at the spinal cord was observed in experiments using high-frequency stimulation, suggesting that wind-up was caused by inputs of A-fibers without the involvement of C-fibers. Magnetic and monopolar stimulations are minimally invasive and useful methods for observing the wind-up of the flexion reflex in humans. Monopolar stimulation is convenient because it does not require special equipment. There is at least a partial mechanism underlying the wind-up of the flexion reflex that does not require C-fibers.

    DOI: 10.3389/fnins.2022.837340

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  4. Age and sex effects on paired-pulse suppression and prepulse inhibition of auditory evoked potentials

    Inui, K; Takeuchi, N; Borgil, B; Shingaki, M; Sugiyama, S; Taniguchi, T; Nishihara, M; Watanabe, T; Suzuki, D; Motomura, E; Kida, T

    FRONTIERS IN NEUROSCIENCE   Vol. 18   page: 1378619   2024.4

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    Responses to a sensory stimulus are inhibited by a preceding stimulus; if the two stimuli are identical, paired-pulse suppression (PPS) occurs; if the preceding stimulus is too weak to reliably elicit the target response, prepulse inhibition (PPI) occurs. PPS and PPI represent excitability changes in neural circuits induced by the first stimulus, but involve different mechanisms and are impaired in different diseases, e.g., impaired PPS in schizophrenia and Alzheimer’s disease and impaired PPI in schizophrenia and movement disorders. Therefore, these measures provide information on several inhibitory mechanisms that may have roles in clinical conditions. In the present study, PPS and PPI of the auditory change-related cortical response were examined to establish normative data on healthy subjects (35 females and 32 males, aged 19–70 years). We also investigated the effects of age and sex on PPS and PPI to clarify whether these variables need to be considered as biases. The test response was elicited by an abrupt increase in sound pressure in a continuous sound and was recorded by electroencephalography. In the PPS experiment, the two change stimuli to elicit the cortical response were a 15-dB increase from the background of 65 dB separated by 600 ms. In the PPI experiment, the prepulse and test stimuli were 2- and 10-dB increases, respectively, with an interval of 50 ms. The results obtained showed that sex exerted similar effects on the two measures, with females having stronger test responses and weaker inhibition. On the other hand, age exerted different effects: aging correlated with stronger test responses and weaker inhibition in the PPS experiment, but had no effects in the PPI experiment. The present results suggest age and sex biases in addition to normative data on PPS and PPI of auditory change-related potentials. PPS and PPI, as well as other similar paradigms, such as P50 gating, may have different and common mechanisms. Collectively, they may provide insights into the pathophysiologies of diseases with impaired inhibitory function.

    DOI: 10.3389/fnins.2024.1378619

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  5. Auditory sensory suppression and personality traits using Bear-Fedio inventory

    Takeuchi, N; Fujita, K; Taniguchi, T; Kinukawa, T; Sugiyama, S; Kanemoto, K; Nishihara, M; Inui, K

    CURRENT PSYCHOLOGY   Vol. 43 ( 11 ) page: 9598 - 9601   2024.3

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    Epilepsy is considered to be related to deficits in suppression function and is also known to be associated with specific character traits. In this study, we used paired-pulse suppression of change-related cortical responses and the Bear-Fedio personality inventory (BFI) in 34 healthy adults. With a continuous sound duration of 2,000 ms, change-related responses were elicited twice at 1,100 and 1,700 ms. The P50/N100 amplitude was used to calculate the degree of paired-pulse suppression. Results showed that the suppression rate was negatively correlated with the total BFI score (r = − 0.50, p = 0.004) as well as 9 of the 18 subscales (− 0.5 < r ≤ − 0.3). A significant negative correlation was also found between the amplitude of the response to the first stimulus and the total BFI score (r = − 0.64, p = 8.8*10− 5). These findings suggest that inhibitory function is linked to epilepsy personality traits as indexed by the BFI.

    DOI: 10.1007/s12144-023-05082-2

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  6. Intraoperative hypotension affects postoperative acute kidney injury depending on the invasiveness of abdominal surgery: A retrospective cohort study

    Fujii, T; Takakura, M; Taniguchi, T; Tamura, T; Nishiwaki, K

    MEDICINE   Vol. 102 ( 48 ) page: e36465   2023.12

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    Intraoperative hypotension (IOH) or highly invasive surgery adversely affects postoperative clinical outcomes. It is, however, unclear whether IOH affects postoperative acute kidney injury (AKI) depending on the invasiveness of abdominal surgery. We speculated that IOH in highly invasive abdominal surgery is a significant risk factor for postoperative AKI. We retrospectively reviewed the data of 448 patients who underwent abdominal surgery. Patients were divided into 3 groups: highly (such as pancreaticoduodenectomy and hepatectomy), moderately (open abdominal surgery), and minimally (laparoscopic surgery) invasive surgeries. The association between the time-weighted average (TWA) of mean arterial pressure (MAP) values (≤60 and ≤ 55 mm Hg) and AKI occurrences in each group was assessed. Postoperative AKI occurred after highly, moderately, and minimally invasive surgeries in 33 of 222 (14.9%), 14 of 110 (12.7%), and 12 of 116 (10.3%) cases, respectively (P = .526). The median [interquartile range] of TWA-MAP ≤ 60 mm Hg, as an IOH parameter, was 0.94 [0.33-2.08] mm Hg in highly, 0.54 [0.16-1.46] mm Hg in moderately, and 0.14 [0.03-0.57] mm Hg in minimally invasive surgeries (P < 0001). In addition, there was a significant association between TWA-MAP and AKI in highly invasive surgery, unlike in moderately and minimally invasive surgery, with adjusted odds ratios (95% confidence interval) for TWA-MAP ≤ 60 and ≤ 55 mm Hg associated with AKI of 1.23 [1.00-1.52] (P = .049) and 1.55 [1.02-2.36] (P = .041), respectively. Intraoperative MAP ≤ 60 mm Hg in highly invasive abdominal surgery is associated with postoperative AKI, compared to moderately and minimally invasive surgeries. Additionally, low MAP thresholds in highly invasive surgery increase postoperative AKI risk.

    DOI: 10.1097/MD.0000000000036465

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  7. 公益社団法人日本麻酔科学会第70回学術集会講演特集号 学術委員会:学会賞記念講演 ヒト屈曲反射ワインドアップ観察の低侵襲手法

    谷口 智哉, 西脇 公俊, 乾 幸二

    麻酔   Vol. 72 ( 13 ) page: 147 - 152   2023.11

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    DOI: 10.18916/masui.2023130022

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  8. Mechanisms of short- and long-latency sensory suppression: magnetoencephalography study. International journal

    Nobuyuki Takeuchi, Kohei Fujita, Tomoya Taniguchi, Tomoaki Kinukawa, Shunsuke Sugiyama, Kousuke Kanemoto, Makoto Nishihara, Koji Inui

    Neuroscience   Vol. 514   page: 92 - 99   2023.3

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    Prepulse inhibition (PPI) is sensory suppression whose mechanism (i.e., whether PPI originates from specific inhibitory mechanisms) remains unclear. In this study, we applied the combination of short-latency PPI and long-latency paired pulse suppression in 17 healthy subjects using magnetoencephalography to investigate the mechanisms of sensory suppression. Repeats of a 25-ms pure tone without a blank at 800 Hz and 70 dB were used for a total duration of 1600 ms. To elicit change-related cortical responses, the sound pressure of two consecutive tones in this series at 1300 ms was increased to 80 dB (Test). For the conditioning stimuli, the sound pressure was increased to 73 dB at 1250 ms (Pre 1) and 80 dB at 700 ms (Pre 2). Six stimuli were randomly presented as follows: (1) Test alone, (2) Pre 1 alone, (3) Pre 1 + Test, (4) Pre 2 + Test, (5) Pre 2 + Pre 1, and (6) Pre 2 + Pre 1 + Test. The inhibitory effects of the conditioning stimuli were evaluated using N100m/P200m components. The results showed that both Pre 1 and Pre 2 significantly suppressed the Test response. Moreover, the inhibitory effects of Pre 1 and Pre 2 were additive. However, when both prepulses were present, Pre 2 significantly suppressed the Pre 1 response, suggesting that the Pre 1 response amplitude was not a determining factor for the degree of suppression. These results suggested that the suppression originated from a specific inhibitory circuit independent of the excitatory pathway.

    DOI: 10.1016/j.neuroscience.2022.11.016

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  9. The 40-Hz auditory steady-state response enhanced by beta-band subharmonics. International journal

    Shunsuke Sugiyama, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Kazutaka Ohi, Toshiki Shioiri, Makoto Nishihara, Koji Inui

    Frontiers in neuroscience   Vol. 17   page: 1127040 - 1127040   2023.2

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    The 40-Hz auditory steady-state response (ASSR) has received special attention as an index of gamma oscillations owing to its association with various neuropsychiatric disorders including schizophrenia. When a periodic stimulus is presented, oscillatory responses are often elicited not only at the stimulus frequency, but also at its harmonic frequencies. However, little is known about the effect of 40-Hz subharmonic stimuli on the activity of the 40-Hz ASSR. In the present magnetoencephalography study, we focused on the nature of oscillation harmonics and examined oscillations in a wide frequency range using a time-frequency analysis during the 6.67-, 8-, 10-, 13.3-, 20-, and 40-Hz auditory stimuli in 23 healthy subjects. The results suggested that the 40-Hz ASSR represents activation of a specific circuit tuned to this frequency. Particularly, oscillations elicited by 13.3- and 20-Hz stimuli exhibited significant enhancement at 40 Hz without changing those at the stimulus frequency. In addition, it was found that there was a non-linear response to stimulation in the beta band. We also demonstrated that the inhibition of beta to low-gamma oscillations by the 40-Hz circuit contributed to the violation of the rule that harmonic oscillations gradually decrease at higher frequencies. These findings can advance our understanding of oscillatory abnormalities in patients with schizophrenia in the future.

    DOI: 10.3389/fnins.2023.1127040

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  10. Target site of prepulse inhibition of the trigeminal blink reflex in humans International journal

    Koji Inui, Yasushi Itoh, Borgil Bayasgalan, Megumi Shingaki, Tomoya Taniguchi, Eishi Motomura, Tetsuo Kida

    The Journal of Neuroscience   Vol. 43 ( 2 ) page: 261 - 269   2023.1

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    Despite the clinical significance of prepulse inhibition (PPI), the mechanisms are not well understood. Herein, we present our investigation of PPI in the R1 component of electrically induced blink reflexes. The effect of a prepulse was explored with varying prepulse-test intervals (PTIs) of 20-600 ms in 4 females and 12 males. Prepulse-test combinations included: stimulation of the supraorbital nerve (SON)-SON (Exp 1), sound-sound (Exp 2), the axon of the facial nerve-SON (Exp 3), sound-SON (Exp 4), and SON-SON with a long trial-trial interval (Exp 5). Results showed that 1) leading weak SON stimulation reduced SON-induced ipsilateral R1 with a maximum effect at a PTI of 140 ms, 2) the sound-sound paradigm resulted in a U-shaped inhibition time course of the auditory startle reflex (ASR) peaking at 140 ms PTI, 3) facial nerve stimulation showed only a weak effect on R1, 4) a weak sound prepulse facilitated R1 but strongly inhibited SON-induced late blink reflexes (LateR) with a similar U-shaped curve, and 5) LateR in Exp 5 was almost completely absent at PTIs longer than 80 ms. These results indicate that the principal sensory nucleus is responsible for R1 PPI. Inhibition of ASR or LateR occurs at a point in the startle reflex circuit where auditory and somatosensory signals converge. Although the two inhibitions are different in location, their similar time courses suggest similar neural mechanisms. As R1 has a simple circuit and is stable, R1 PPI helps to clarify PPI mechanisms.SIGNIFICANCE STATEMENT:Prepulse inhibition (PPI) is a phenomenon in which the startle response induced by a startle stimulus is suppressed by a preceding non-startle stimulus. This study demonstrated that the R1 component of the trigeminal blink reflex shows clear PPI despite R1 generation within a circuit consisting of the trigeminal and facial nuclei, without startle reflex circuit involvement. Thus, PPI is not specific to the startle reflex. In addition, PPI of R1, the auditory startle reflex, and the trigeminal late blink reflex showed similar time courses in response to the prepulse-test interval, suggesting similar mechanisms regardless of inhibition site. R1 PPI, in conjunction with other paradigms with different prepulse-test combinations, would increase understanding of underlying mechanisms.

    DOI: 10.1523/JNEUROSCI.1468-22.2022

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  11. 投稿論文 症例報告 ミニトラック挿入後にボールバルブ血餅によって重篤な気道閉塞合併症を生じた1症例

    高倉 将司, 藤井 祐, 喜多 桂, 谷口 智哉, 天野 靖大, 鈴木 章悟, 西脇 公俊

    麻酔   Vol. 71 ( 11 ) page: 1201 - 1204   2022.11

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    DOI: 10.18916/j01397.2023016077

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  12. Favorable glycemic control using artificial pancreas STG<sup>®</sup>-55 for severe perioperative hyperglycemia in a patient with infected abdominal aortic aneurysm: a case report

    Taniguch Tomoya, Hirai Takahiro, Fujii Tasuku, Takakura Masashi, Kita Kei, Suzuki Shogo, Nishiwaki Kimitoshi

    Journal of the Japanese Society of Intensive Care Medicine   Vol. 29 ( 6 ) page: 601 - 602   2022.11

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    Language:Japanese   Publisher:The Japanese Society of Intensive Care Medicine  

    DOI: 10.3918/jsicm.29_601

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  13. Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation. International journal

    Shunsuke Sugiyama, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Kazutaka Ohi, Toshiki Shioiri, Makoto Nishihara, Koji Inui

    Cerebral cortex (New York, N.Y. : 1991)   Vol. 32 ( 13 ) page: 2785 - 2796   2022.6

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    Gamma oscillations have received considerable attention owing to their association with cognitive function and various neuropsychiatric disorders. However, interactions of gamma oscillations at different frequency bands in humans remain unclear. In the present magnetoencephalographic study, brain oscillations in a wide frequency range were examined using a time-frequency analysis during the 20-, 30-, 40-, and 50-Hz auditory stimuli in 21 healthy subjects. First, dipoles for auditory steady-state response (ASSR) were estimated and interaction among oscillations at 10-60 Hz was examined using the source strength waveforms. Results showed the suppression of ongoing low-gamma oscillations at approximately 30 Hz during stimulation at 40 Hz. Second, multi-dipole analyses suggested that the main dipole for ASSR and dipoles for suppressed low-frequency gamma oscillations were distinct. Third, an all-sensor analysis was performed to clarify the distribution of the 40-Hz ASSR and suppression of low-frequency gamma oscillations. Notably, the area of suppression surrounded the center of the 40-Hz ASSR and showed a trend of extending to the vertex, indicating that different groups of neurons were responsible for these two gamma oscillations and that the 40-Hz oscillation circuit have specific inhibitory innervation to the low-gamma circuit.

    DOI: 10.1093/cercor/bhab381

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  14. Risk factors for postoperative sore throat associated with i-gel™, a supraglottic airway device. Reviewed

    Tomoya Taniguchi, Tasuku Fujii, Nanako Taniguchi, Kimitoshi Nishiwaki

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 319 - 326   2022.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    i-gel™ is a supraglottic airway device widely used for airway management during general anesthesia as an alternative to tracheal intubation. It sometimes results in a sore throat postoperatively; however, the risk factors for a postoperative sore throat caused by i-gel remain unclear. Here, we clarify the risk factors for a postoperative sore throat associated with i-gel insertion. We retrospectively reviewed the data of 426 adult patients who received general anesthesia with i-gel at our institution from January 2018 to December 2019. The incidence of postoperative sore throat and intraoperative data (size of i-gel, number of insertion attempts, total insertion time, and dose of the neuromuscular blocker and opioid) were evaluated. Logistic regression analysis was performed to identify the risk factors. Postoperative sore throat following i-gel insertion occurred in 24/426 patients (5.6%). The insertion time was significantly associated with the incidence of postoperative sore throat in the univariate analysis, but not in the multivariate analysis (P=0.519). Increased doses of neuromuscular blockers before i-gel insertion (odds ratio [OR], 5.46; 95% confidence interval [CI], 1.50-19.80; P=0.001) and reduced doses of intraoperative fentanyl (OR, 0.51; 95% CI, 0.28-0.93; P=0.028) were risk factors in the univariate and multivariate analyses. In the subgroup that used neuromuscular blockers before i-gel insertion, only an increased dose of neuromuscular blocker (OR, 17.2; 95%, CI 1.06-280; P=0.046) was an associated risk factor in the univariate and multivariate analyses. Overall, increased doses of neuromuscular blockers before i-gel insertion could contribute to the development of postoperative sore throat.

    DOI: 10.18999/nagjms.84.2.319

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  15. Mechanisms of Long-Latency Paired Pulse Suppression: MEG Study. International journal

    Nobuyuki Takeuchi, Kohei Fujita, Tomoya Taniguchi, Tomoaki Kinukawa, Shunsuke Sugiyama, Kousuke Kanemoto, Makoto Nishihara, Koji Inui

    Brain topography   Vol. 35 ( 2 ) page: 241 - 250   2022.3

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    Paired pulse suppression is an electrophysiological method used to evaluate sensory suppression and often applied to patients with psychiatric disorders. However, it remains unclear whether the suppression comes from specific inhibitory mechanisms, refractoriness, or fatigue. In the present study, to investigate mechanisms of suppression induced by an auditory paired pulse paradigm in 19 healthy subjects, magnetoencephalography was employed. The control stimulus was a train of 25-ms pure tones of 65 dB SPL for 2500 ms. In order to evoke a test response, the sound pressure of two consecutive tones at 2200 ms in the control sound was increased to 80 dB (Test stimulus). Similar sound pressure changes were also inserted at 1000 (CS2) and 1600 (CS1) ms as conditioning stimuli. Four stimulus conditions were used; (1) Test alone, (2) Test + CS1, (3) Test + CS1 + CS2, and (4) Test + CS2, with the four sound stimuli randomly presented and cortical responses averaged at least 100 times for each condition. The baseline-to-peak and peak-to-peak amplitudes of the P50m, N100m, and P200m components of the test response were compared among the four conditions. In addition, the response to CS1 was compared between conditions (2) and (3). The results showed significant test response suppression by CS1. While the response to CS1 was significantly suppressed when CS2 was present, it did not affect suppression of the test response by CS1. It was thus suggested that the amplitude of the response to a conditioning stimulus is not a factor to determine the inhibitory effects of the test response, indicating that suppression is due to an external influence on the excitatory pathway.

    DOI: 10.1007/s10548-021-00878-6

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  16. 疼痛関連評価の現状と今後:どうすれば痛みを客観視できるのか 慢性疼痛の臨床応用に向けた生理学的評価の意義

    西原 真理, 絹川 友章, 谷口 智哉, 藤田 雄輝, 神谷 妙子, 柴田 由加, 竹内 伸行, 杉山 俊介, 藤田 貢平, 乾 幸二, 牛田 享宏

    臨床神経生理学   Vol. 49 ( 5 ) page: 313 - 313   2021.10

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  17. 脳波計を用いた誘発電位とTCI、STAI、BFIによる性格形質

    竹内 伸行, 藤田 貢平, 谷口 智哉, 絹川 友章, 杉山 俊介, 兼本 浩祐, 乾 幸二, 西原 真理

    精神神経学雑誌   ( 2021特別号 ) page: S557 - S557   2021.9

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

  18. Conditioned Pain Modulation: Comparison of the Effects on Nociceptive and Non-nociceptive Blink Reflex. International journal

    Tomoaki Alex Kinukawa, Koji Inui, Tomoya Taniguchi, Nobuyuki Takeuchi, Shunsuke Sugiyama, Makoto Nishihara, Kimitoshi Nishiwaki, Ryusuke Kakigi

    Neuroscience   Vol. 468   page: 168 - 175   2021.8

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    Although conditioned pain modulation (CPM) is considered to represent descending pain inhibitory mechanisms triggered by noxious stimuli applied to a remote area, there have been no previous studies comparing CPM between pain and tactile systems. In this study, we compared CPM between the two systems objectively using blink reflexes. Intra-epidermal electrical stimulation (IES) and transcutaneous electrical stimulation (TS) were applied to the right skin area over the supraorbital foramen to evoke a nociceptive or a non-nociceptive blink reflex, respectively, in 15 healthy males. In the test session, IES or TS were applied six times and subjects reported the intensity of each stimulus on a numerical rating scale (NRS). Blink reflexes were measured using electromyography (R2). The first and second sessions were control sessions, while in the third session, the left hand was immersed in cold water at 10 °C as a conditioning stimulus. The magnitude of the R2 blink and NRS scores were compared among the sessions by 2-way ANOVA. Both the NRS score and nociceptive R2 were significantly decreased in the third session for IES, with a significant correlation between the two variables; whereas, TS-induced non-nociceptive R2 did not change among the sessions. Although the conditioning stimulus decreased the NRS score for TS, the CPM effect was significantly smaller than that for IES (p = 0.002). The present findings suggest the presence of a pain-specific CPM effect to a heterotopic noxious stimulus.

    DOI: 10.1016/j.neuroscience.2021.06.019

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  19. The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders. International journal

    Shunsuke Sugiyama, Kazutaka Ohi, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Eishi Motomura, Makoto Nishihara, Toshiki Shioiri, Koji Inui

    Frontiers in psychiatry   Vol. 12   page: 644541 - 644541   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Sensory processing is disrupted in several psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder. In this review, we focus on the electrophysiological auditory steady-state response (ASSR) driven by high-frequency stimulus trains as an index for disease-associated sensory processing deficits. The ASSR amplitude is suppressed within the gamma band (≥30 Hz) among these patients, suggesting an imbalance between GABAergic and N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission. The reduced power and synchronization of the 40-Hz ASSR are robust in patients with schizophrenia. In recent years, similar ASSR deficits at gamma frequencies have also been reported in patients with bipolar disorder and autism spectrum disorder. We summarize ASSR abnormalities in each of these psychiatric disorders and suggest that the observed commonalities reflect shared pathophysiological mechanisms. We reviewed studies on phase resetting in which a salient sensory stimulus affects ASSR. Phase resetting induces the reduction of both the amplitude and phase of ASSR. Moreover, phase resetting is also affected by rare auditory stimulus patterns or superimposed stimuli of other modalities. Thus, sensory memory and multisensory integration can be investigated using phase resetting of ASSR. Here, we propose that ASSR amplitude, phase, and resetting responses are sensitive indices for investigating sensory processing dysfunction in psychiatric disorders.

    DOI: 10.3389/fpsyt.2021.644541

    Web of Science

    Scopus

    PubMed

  20. 痛みの客観的な評価と臨床活用への挑戦 電気生理学的手法による痛みの評価

    西原 真理, 絹川 友章, 谷口 智哉, 柴田 由加, 乾 幸二, 牛田 享宏

    臨床神経生理学   Vol. 48 ( 5 ) page: 470 - 470   2020.10

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    Language:Japanese   Publisher:(一社)日本臨床神経生理学会  

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MISC 8

  1. アラジール症候群に対する同種死体肝移植術中に可逆性の両側散瞳固定をきたした一例

    仲本 正之, 天野 靖大, 谷口 智哉, 西脇 公俊

    日本集中治療医学会雑誌   Vol. 29 ( Suppl.1 ) page: 643 - 643   2022.11

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    Language:Japanese   Publisher:(一社)日本集中治療医学会  

  2. ミニトラック挿入後にボールバルブ血餅によって重篤な気道閉塞合併症を生じた1症例—Severe Ball-valve Airway Obstruction by a Blood Clot after Cricothyroid Mini-tracheostomy : A Case Report

    高倉 将司, 藤井 祐, 喜多 桂, 谷口 智哉, 天野 靖大, 鈴木 章悟, 西脇 公俊

    麻酔 = The Japanese journal of anesthesiology : 日本麻酔科学会準機関誌   Vol. 71 ( 11 ) page: 1201 - 1204   2022.11

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    Language:Japanese   Publisher:克誠堂出版  

    ミニトラック(スミスメディカル・ジャパン,東京)挿入後のボールバルブ血餅による気道閉塞はまれな致死的合併症である。本症例は迅速な軟性気管支鏡検査で挿管チューブ先端付近にボールバルブ血餅を確認し,原因診断ができたが,血餅は除去困難であった。血餅を右主気管支に押し込み,片肺換気にして気道を開通させたため,循環破綻せずに救命可能であった。(著者抄録)

    CiNii Books

  3. 慢性疼痛の臨床応用に向けた生理学的評価の意義

    西原真理, 絹川友章, 谷口智哉, 藤田雄輝, 神谷妙子, 柴田由加, 竹内伸行, 杉山俊介, 藤田貢平, 乾幸二, 牛田享宏

    臨床神経生理学(Web)   Vol. 49 ( 5 )   2021

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  4. 体外式除細動器が使用不能になった植込み型補助人工心臓HeartMate2による電磁干渉

    谷口智哉, 藤井祐, 谷口菜奈子, 尾関奏子, 西脇公俊

    Cardiovascular Anesthesia   Vol. 24 ( Suppl (CD-ROM) ) page: 176 - 176   2020

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    Language:Japanese   Publisher:(一社)日本心臓血管麻酔学会  

    J-GLOBAL

  5. 症例報告:重症周術期高血糖に対して人工膵臓STG-55を用いて良好な血糖管理を得た1症例

    谷口智哉, 平井昂宏, 藤井祐, 田村高廣, 鈴木章悟, 西脇公俊

    日本集中治療医学会東海北陸支部学術集会プログラム・抄録集(Web)   Vol. 4th   2020

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  6. 電気生理学的手法による痛みの評価

    西原真理, 絹川友章, 谷口智哉, 柴田由加, 乾幸二, 牛田享宏

    臨床神経生理学(Web)   Vol. 48 ( 5 )   2020

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  7. i-gelと気管挿管による術後口腔内合併症の比較

    谷口智哉, 二宮菜奈子, 西脇公俊

    日本麻酔科学会学術集会(Web)   Vol. 66th   2019

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  8. 人工心肺使用手術における両側足底温モニターの重要性

    二宮 菜奈子, 谷口 智哉, 西脇 公俊

    Cardiovascular Anesthesia   Vol. 22 ( Suppl. ) page: 162 - 162   2018.9

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    Language:Japanese   Publisher:(一社)日本心臓血管麻酔学会  

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Presentations 3

  1. 周術期高血糖に対して人工膵臓STG-55を用いて良好な血糖管理を得た1症例

    谷口 智哉、平井 昂宏、藤井 祐 、田村 高廣 、鈴木 章悟 、西脇 公俊

    日本集中治療学会第4回東海北陸支部学術集会 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  2. 体外式除細動器が使用不能になった植え込み型人工心臓HeartMate2による電磁干渉

    谷口 智哉、藤井 祐、谷口 菜奈子 、尾関 奏子、西脇 公俊

    日本心臓血管麻酔学会 第25回学術大会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  3. i-gelと気管挿管による術後口腔内合併症の比較

    谷口 智哉, 二宮 菜奈子, 西脇 公俊

    日本麻酔科学会 第66回学術集会 

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    Event date: 2019.5 - 2019.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. ヒトにおけるwind-up現象の定量化と機序の解明

    Grant number:24K19458  2024.4 - 2028.3

    科学研究費助成事業  若手研究

    谷口 智哉

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )