Updated on 2021/08/26

写真a

 
YOGO Katsunori
 
Organization
Graduate School of Medicine Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(理学) ( 2013.3 ) 

Research Interests 7

  1. Radiation Biology

  2. Radiation Therapy

  3. Medical Physics

  4. Nano medicine

  5. Cherenkov emission

  6. Scintillator

  7. DNA damage

Research Areas 9

  1. Life Science / Radiological sciences  /  医学物理学

  2. Energy Engineering / Quantum beam science  /  医学物理学

  3. Nanotechnology/Materials / Nanobioscience

  4. Life Science / Radiological sciences

  5. Natural Science / Experimental studies related to particle-, nuclear-, cosmic ray and astro-physics

  6. Life Science / Biophysics  / DNA damage

  7. Life Science / Radiological sciences

  8. Life Science / Molecular biology  / Radiation Biology

  9. Others / Others  / Medical Physics

▼display all

Current Research Project and SDGs 3

  1. 放射線誘発の発光を利用した放射線治療の品質保証ツール開発

  2. 放射線治療併用の放射線防護剤の開発

  3. 放射線治療併用の放射線増感剤の開発

Research History 1

  1. Nagoya University   Graduate School of Medicine   Assistant Professor

    2020.4

Professional Memberships 10

  1. 日本医学物理学会

  2. 日本応用物理学会

  3. ナノ学会

  4. 日本放射線影響学会

  5. 日本放射線腫瘍学会

  6. ナノ学会

  7. 日本放射線腫瘍学会

  8. 日本放射線影響学会

  9. 日本応用物理学会

  10. 日本医学物理学会

▼display all

 

Papers 25

  1. Protective Effects of Amino Acids on Plasmid DNA Damage Induced by Therapeutic Carbon Ions. Reviewed International journal

    Katsunori Yogo, Chieko Murayama, Ryoichi Hirayama, Ken-Ichiro Matsumoto, Ikuo Nakanishi, Hiromichi Ishiyama, Hiroshi Yasuda

    Radiation research   Vol. 196 ( 2 ) page: 197 - 203   2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Radioprotectors with few side effects are useful for carbon-ion therapy, which directly induces clustering damage in DNA. With the aim of finding the most effective radioprotector, we investigated the effects of selected amino acids which might have chemical DNA-repair functions against therapeutic carbon ions. In the current study, we employed five amino acids: tryptophan (Trp), cysteine (Cys), methionine (Met), valine (Val) and alanine (Ala). Samples of supercoiled pBR322 plasmid DNA with a 17 mM amino acid were prepared in TE buffer (10 mM Tris, 1 mM ethylenediaminetetraacetic acid, pH 7.5). Phosphate buffered saline (PBS) was also used in assays of the 0.17 mM amino acid. The samples were irradiated with carbon-ion beams (290 MeV/u) on 6 cm spread-out Bragg peak at the National Institute of Radiological Sciences-Heavy Ion Medical Accelerator in Chiba, Japan. Breaks in the DNA were detected as changes in the plasmids and quantified by subsequent electrophoresis on agarose gels. DNA damage yields and protection factors for each amino acid were calculated as ratios relative to reagent-free controls. Trp and Cys showed radioprotective effects against plasmid DNA damage induced by carbon-ion beam, both in PBS and TE buffer, comparable to those of Met. The double-strand break (DSB) yields and protective effects of Trp were comparable to those of Cys. The yields of both single-strand breaks and DSBs correlated with the scavenging capacity of hydroxyl radicals (rate constant for scavenging hydroxyl radicals multiplied by the amino acid concentration) in bulk solution. These data indicate that the radioprotective effects of amino acids against plasmid DNA damage induced by carbon ions could be explained primarily by the scavenging capacity of hydroxyl radicals. These findings suggest that some amino acids, such as Trp, Cys and Met, have good potential as radioprotectors for preventing DNA damage in normal tissues in carbon-ion therapy.

    DOI: 10.1667/RADE-21-00033.1

    Web of Science

    Scopus

    PubMed

  2. Three-dimensional dose-distribution measurement of therapeutic carbon-ion beams using a ZnS scintillator sheet. Reviewed International journal

    Katsunori Yogo, Masato Tsuneda, Ryo Horita, Hikaru Souda, Akihiko Matsumura, Hiromichi Ishiyama, Kazushige Hayakawa, Tatsuaki Kanai, Seiichi Yamamoto

    Journal of radiation research     2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The accurate measurement of the 3D dose distribution of carbon-ion beams is essential for safe carbon-ion therapy. Although ionization chambers scanned in a water tank or air are conventionally used for this purpose, these measurement methods are time-consuming. We thus developed a rapid 3D dose-measurement tool that employs a silver-activated zinc sulfide (ZnS) scintillator with lower linear energy transfer (LET) dependence than gadolinium-based (Gd) scintillators; this tool enables the measurement of carbon-ion beams with small corrections. A ZnS scintillator sheet was placed vertical to the beam axis and installed in a shaded box. Scintillation images produced by incident carbon-ions were reflected with a mirror and captured with a charge-coupled device (CCD) camera. A 290 MeV/nucleon mono-energetic beam and spread-out Bragg peak (SOBP) carbon-ion passive beams were delivered at the Gunma University Heavy Ion Medical Center. A water tank was installed above the scintillator with the water level remotely adjusted to the measurement depth. Images were recorded at various water depths and stacked in the depth direction to create 3D scintillation images. Depth and lateral profiles were analyzed from the images. The ZnS-scintillator-measured depth profile agreed with the depth dose measured using an ionization chamber, outperforming the conventional Gd-based scintillator. Measurements were realized with smaller corrections for a carbon-ion beam with a higher LET than a proton. Lateral profiles at the entrance and the Bragg peak depths could be measured with this tool. The proposed method would make it possible to rapidly perform 3D dose-distribution measurements of carbon-ion beams with smaller quenching corrections.

    DOI: 10.1093/jrr/rrab036

    PubMed

  3. Source position measurement by Cherenkov emission imaging from applicators for high-dose-rate brachytherapy. Reviewed International journal

    Katsunori Yogo, Yumiko Noguchi, Kuniyasu Okudaira, Marika Nozawa, Hiromichi Ishiyama, Hiroyuki Okamoto, Hiroshi Yasuda, Hiroshi Oguchi, Seiichi Yamamoto

    Medical physics   Vol. 48 ( 1 ) page: 488 - 499   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: We developed a novel and simple method to measure the source positions in applicators directly for high-dose-rate (HDR) brachytherapy based on Cherenkov emission imaging, and evaluated the performance. METHODS: The light emission from plastic applicators used in cervical cancer treatments, irradiated by an 192 Ir γ-ray source, was captured using a charge-coupled device camera. Moreover, we attached plastics of different shapes, including tapes, tubes, and plates to a metal applicator, to use as screens for the Cherenkov imaging. We determined the source positions and dwell intervals from the light profiles along with the applicator and compared these with preset values and dummy marker measurements. RESULTS: The source positions and dwell intervals measured from the light images were comparable to the dummy marker measurements and preset values. The distance from the applicator tip to the first source positions agreed with the dummy marker measurements within 0.2 mm for the plastic tandem. The dwell intervals measured using the Cherenkov method agreed with the preset values within 0.6 mm. The distances measured with three plastic types on the metal applicator also agreed with the dummy marker measurements within 0.2 mm. The dwell intervals measured using the plastic tape agreed with the preset values within 0.7 mm. CONCLUSIONS: The proposed method should be suitable for rapid and easy quality assurance (QA) investigations in HDR brachytherapy, as it enables source position using a single image. The method allows for real-time, filmless measurements of the source positions to be obtained and is useful for rapid feedback in QA procedures.

    DOI: 10.1002/mp.14606

    Web of Science

    Scopus

    PubMed

  4. Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy. Reviewed International journal

    Katsunori Yogo, Masaki Misawa, Morihito Shimizu, Hidetoshi Shimizu, Tomoki Kitagawa, Ryoichi Hirayama, Hiromichi Ishiyama, Takako Furukawa, Hiroshi Yasuda

    International journal of nanomedicine   Vol. 16   page: 359 - 370   2021

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Purpose: Gold nanoparticles (AuNPs) are candidate radiosensitizers for medium-energy photon treatment, such as γ-ray radiation in high-dose-rate (HDR) brachytherapy. However, high AuNP concentrations are required for sufficient dose enhancement for clinical applications. Here, we investigated the effect of positively (+) charged AuNP radiosensitization of plasmid DNA damage induced by 192Ir γ-rays, and compared it with that of negatively (-) charged AuNPs. Methods: We observed DNA breaks and reactive oxygen species (ROS) generation in the presence of AuNPs at low concentrations. pBR322 plasmid DNA exposed to 64 ng/mL AuNPs was irradiated with 192Ir γ-rays via HDR brachytherapy. DNA breaks were detected by observing the changes in the form of the plasmid and quantified by agarose gel electrophoresis. The ROS generated by the AuNPs were measured with the fluorescent probe sensitive to ROS. The effects of positively (+) and negatively (-) charged AuNPs were compared to study the effect of surface charge on dose enhancement. Results: +AuNPs at lower concentrations promoted a comparable level of radiosensitization by producing both single-stranded breaks (SSBs) and double-stranded breaks (DSBs) than those used in cell assays and Monte Carlo simulation experiments. The dose enhancement factor (DEF) for +AuNPs was 1.3 ± 0.2 for SSBs and 1.5 ± 0.4 for DSBs. The ability of +AuNPs to augment plasmid DNA damage is due to enhanced ROS generation. While -AuNPs generated similar ROS levels, they did not cause significant DNA damage. Thus, dose enhancement using low concentrations of +AuNPs presumably occurred via DNA binding or increasing local +AuNP concentration around the DNA. Conclusion: +AuNPs at low concentrations displayed stronger radiosensitization compared to -AuNPs. Combining +AuNPs with 192Ir γ-rays in HDR brachytherapy is a candidate method for improving clinical outcomes. Future development of cancer cell-specific +AuNPs would allow their wider application for HDR brachytherapy.

    DOI: 10.2147/IJN.S292105

    Web of Science

    Scopus

    PubMed

  5. Potential Mechanisms for Protective Effect of D-Methionine on Plasmid DNA Damage Induced by Therapeutic Carbon Ions.

    Yogo K, Murayama C, Fujisawa Y, Maeyama T, Hirayama R, Ogawa Y, Matsumoto KI, Nakanishi I, Yasuda H, Ishiyama H, Hayakawa K

    Radiation research   Vol. 193 ( 6 ) page: 513 - 519   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1667/RR15502.1

    Web of Science

    Scopus

    PubMed

  6. Scintillator screen for measuring low-dose halo in scanning carbon-ion therapy

    Yogo Katsunori, Tatsuno Yuya, Souda Hikaru, Matsumura Akihiko, Tsuneda Masato, Hirano Yoshiyuki, Ishiyama Hiromichi, Saito Akito, Ozawa Shuichi, Nagata Yasushi, Nakano Takashi, Hayakawa Kazushige, Kanai Tatsuaki

    RADIATION MEASUREMENTS   Vol. 133   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radmeas.2020.106299

    Web of Science

    Scopus

  7. Imaging Cherenkov emission for quality assurance of high-dose-rate brachytherapy.

    Yogo K, Matsushita A, Tatsuno Y, Shimo T, Hirota S, Nozawa M, Ozawa S, Ishiyama H, Yasuda H, Nagata Y, Hayakawa K

    Scientific reports   Vol. 10 ( 1 ) page: 3572   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-60519-z

    Web of Science

    Scopus

    PubMed

  8. A method of absorbed dose determination using vitamin B2 water for optical imaging of X-rays from high energy medical linear accelerators

    Toyonaga Chihiro, Yamamoto Seiichi, Yogo Katsunori, Okudaira Kuniyasu, Kawabata Fumitaka, Nakaya Takayoshi, Oguchi Hiroshi

    RADIATION MEASUREMENTS   Vol. 131   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radmeas.2019.106227

    Web of Science

    Scopus

  9. Scintillator screen for measuring dose distribution in scanned carbon-ion therapy

    Yogo Katsunori, Tatsuno Yuya, Souda Hikaru, Matsumura Akihiko, Tsuneda Masato, Hirano Yoshiyuki, Ishiyama Hiromichi, Saito Akito, Ozawa Shuichi, Nagata Yasushi, Nakano Takashi, Hayakawa Kazushige, Kanai Tatsuaki

    RADIATION MEASUREMENTS   Vol. 129   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radmeas.2019.106207

    Web of Science

    Scopus

  10. Imaging of Ir-192 source using a high energy gamma camera for high-dose-rate brachytherapy

    Yamamoto Seiichi, Yogo Katsunori, Noguchi Yumiko, Nakaya Takayoshi, Okudaira Kuniyasu

    RADIATION MEASUREMENTS   Vol. 126   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radmeas.2019.106128

    Web of Science

    Scopus

  11. Three-dimensional (3D) dose distribution measurements of proton beam using a glass plate

    Horita Ryo, Yamamoto Seiichi, Yogo Katsunori, Komori Masataka, Toshito Toshiyuki

    BIOMEDICAL PHYSICS & ENGINEERING EXPRESS   Vol. 5 ( 4 )   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/2057-1976/ab169e

    Web of Science

    Scopus

  12. Tolerance levels of mass density for CT number calibration in photon radiation therapy

    Nakao Minoru, Ozawa Shuichi, Yogo Katsunori, Miura Hideharu, Yamada Kiyoshi, Hosono Fumika, Hayata Masahiro, Miki Kentaro, Nakashima Takeo, Ochi Yusuke, Kawahara Daisuke, Morimoto Yoshiharu, Yoshizaki Toru, Nozaki Hiroshige, Habara Kosaku, Nagata Yasushi

    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS   Vol. 20 ( 6 ) page: 45-52   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/acm2.12601

    Web of Science

    Scopus

    PubMed

  13. Estimation of the three-dimensional (3D) dose distribution of electron beams from medical linear accelerator (LINAC) using plastic scintillator plate

    Horita Ryo, Yamamoto Seiichi, Yogo Katsunori, Hirano Yoshiyuki, Okudaira Kuniyasu, Kawabata Fumitaka, Nakaya Takayoshi, Komori Masataka, Oguchi Hiroshi

    RADIATION MEASUREMENTS   Vol. 124   page: 103-108   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.radmeas.2019.04.002

    Web of Science

    Scopus

  14. Risk factors for radiotherapy incidents: a single institutional experience.

    Ishiyama H, Shuto N, Terazaki T, Noda S, Ishigami M, Yogo K, Hayakawa K

    Medical dosimetry : official journal of the American Association of Medical Dosimetrists     2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.meddos.2017.12.006

    PubMed

  15. Tolerance levels of CT number to electron density table for photon beam in radiotherapy treatment planning system.

    Nakao M, Ozawa S, Yamada K, Yogo K, Hosono F, Hayata M, Saito A, Miki K, Nakashima T, Ochi Y, Kawahara D, Morimoto Y, Yoshizaki T, Nozaki H, Habara K, Nagata Y

    Journal of applied clinical medical physics   Vol. 19 ( 1 ) page: 271-275   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/acm2.12226

    PubMed

  16. Split-VMAT technique to control the expiratory breath-hold time in liver stereotactic body radiation therapy.

    Lin YH, Ozawa S, Miura H, Yogo K, Nakashima T, Miki K, Tsuda S, Ochi Y, Kawahara D, Kimura T, Saito A, Nagata Y

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)   Vol. 40   page: 17-23   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejmp.2017.06.022

    PubMed

  17. Practical use of a plastic scintillator for quality assurance of electron beam therapy.

    Yogo K, Tatsuno Y, Tsuneda M, Aono Y, Mochizuki D, Fujisawa Y, Matsushita A, Ishigami M, Ishiyama H, Hayakawa K

    Physics in medicine and biology   Vol. 62 ( 11 ) page: 4551-4570   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1361-6560/aa67cc

    PubMed

  18. Direct observation of DNA overwinding by reverse gyrase Invited Reviewed

    Taisaku Ogawa, Katsunori Yogo, Shou Furuike, Kazuo Sutoh, Akihiko Kikuchi, Kazuhiko Kinosita Jr

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 112 ( 24 ) page: 7495   2015.6

  19. Microfocus X-ray imaging of the internal geometry of brachytherapy seeds Invited Reviewed

    Tomoyuki Hasegawa , Takashi Hanada , Atsunori Yorozu , Hidetaka Ito , Shinji Masuda , Maki Kawahara , Katsunori Yogo , Kazushige Hayakawa

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine   Vol. 86   page: 13 - 20   2014.4

     More details

  20. Direct observation of strand passage by DNA-topoisomerase and its limited processivity Invited Reviewed

    Katsunori Yogo, Taisaku Ogawa, Masahito Hayashi, Yoshie Harada, Takayuki Nishizaka, Kazuhiko Kinosita Jr

    PloS one   Vol. 7 ( 4 ) page: e34920   2012.4

     More details

    Authorship:Lead author  

  21. Electric quadrupole moment of B-17 and anomalous E2 effective charges for neutron-rich nuclei Invited Reviewed

    H Ogawa, K Asahi, K Sakai, T Suzuki, H Izumi, H Miyoshi, M Nagakura, K Yogo, A Goto, T Suga, T Honda, H Ueno, YX Watanabe, K Yoneda, A Yoshimi, N Fukuda, Y Kobayashi, A Yoshida, T Kubo, M Ishihara, N Imai, N Aoi, WD Schmidt-Ott, G Neyens, S Teughels

    PHYSICAL REVIEW C   Vol. 67 ( 6 )   2003.6

  22. Nuclear spin maser with an artificial feedback mechanism Invited Reviewed

    A Yoshimi, K Asahi, K Sakai, M Tsuda, K Yogo, H Ogawa, T Suzuki, M Nagakura

    PHYSICS LETTERS A   Vol. 304 ( 1-2 ) page: 13 - 20   2002.11

     More details

  23. Gamma-ray spectroscopy of Mg-34 via RI beam fragmentation Invited Reviewed

    K Yoneda, H Sakurai, T Gomi, T Motobayashi, N Aoi, N Fukuda, U Futakami, Z Gacsi, Y Higurashi, N Imai, N Iwasa, H Iwasaki, T Kubo, M Kunibu, M Kurokawa, Z Liu, T Minemura, A Saito, M Serata, S Shimoura, S Takeuchi, YX Watanabe, K Yamada, Y Yanagisawa, K Yogo, A Yoshida, M Ishihara

    NUCLEAR PHYSICS A   Vol. 701   page: 437C - 440C   2002.4

  24. Deformation of Mg-34 studied via in-beam gamma-ray spectroscopy using radioactive-ion projectile fragmentation Invited Reviewed

    K Yoneda, H Sakurai, T Gomi, T Motobayashi, N Aoi, N Fukuda, U Futakami, Z Gacsi, Y Higurashi, N Imai, N Iwasa, H Iwasaki, T Kubo, M Kunibu, M Kurokawa, Z Liu, T Minemura, A Saito, M Serata, S Shimoura, S Takeuchi, YX Watanabe, K Yamada, Y Yanagisawa, K Yogo, A Yoshida, M Ishihara

    PHYSICS LETTERS B   Vol. 499 ( 3-4 ) page: 233 - 237   2001.2

  25. Quenching of neutron E2 effective charge in neutron-rich nuclei and the ground-state spin-parity of C-17 Invited Reviewed

    H Ogawa, K Asahi, H Ueno, H Sakai, H Miyoshi, D Kameda, T Suzuki, H Izumi, N Imai, YX Watanabe, K Yoneda, N Fukuda, H Watanabe, A Yoshimi, W Sato, N Aoi, M Nagakura, T Suga, K Yogo, A Goto, T Honda, Y Kobayashi, WD Schmidt-Ott, G Neyens, S Teughels, A Yoshida, T Kubo, N Ishihara

    EUROPEAN PHYSICAL JOURNAL A   Vol. 13 ( 1-2 ) page: 81 - 85   2000.11

▼display all

Research Project for Joint Research, Competitive Funding, etc. 5

  1. DNA標的型金ナノ粒子と高線量率の放射線治療併用によるがん細胞増感制御法の開発

    2021.4 - 2023.3

    公益財団法人 立松財団   特別研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  2. 放射線影響協会 研究奨励助成金

    2021.4 - 2022.3

      More details

    Authorship:Principal investigator  Grant type:Competitive

  3. 第46回(2021年度)がんその他の悪性新生物研究助成金

    2021.4 - 2022.3

    公益財団法人 愛知県がん研究振興会 

      More details

    Authorship:Principal investigator 

  4. 産総研-名大アライアンス事業

    2019.7

    国内共同研究 

  5. 広島大学放射線災害・医科学研究拠点の共同研究費

    2018.4

    国内共同研究 

KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. 高い線量率の放射線治療ビーム誘発光の生体での可視化

    Grant number:21K07699  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    余語 克紀

      More details

    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

  2. 放射線による水の発光を用いた放射線治療品質管理ツールの開発

    Grant number:18K07679  2018.4 - 2021.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    余語 克紀, 前山 拓哉

      More details

    20-30歳代女性の子宮頸癌の発症率が増加している中、高線量率(HDR)小線源治療は副作用が少なく、集中して高い線量を投与できる優れたがん治療法である。治療では、米粒大の小さなγ線源をがんへ運び、線源の止まる位置と止まる時間を制御し線量を投与する。しかし、高い線量率のため、線源動作のエラーの見逃しから、誤照射事故が起きる可能性がある。線源動作のエラーが目で見て分かりやすい測定ツールがあれば、事故を未然に防ぐのに有用と考えられる。
    HDR小線源治療の進歩に伴い、治療の安全な実施を確保するための品質保証(QA)の重要性が高まっている。しかし、従来のQA法では時間がかかり、いくつかの異なる測定ツールを使用する必要がある。そこで、本研究の目的は、新たにチェレンコフ光の可視化に基づき、HDR小線源治療専用のシンプルなQAツールを開発することである。
    192Irγ線源によって照射された純水からの発光を、CCDカメラを使用して撮影し、投影画像を得た。前年度からの続きで、既存のカメラや光学系を用いても、撮影時間を長くすることで比較的良好な画質が得られた。本年度は、データを仕上げ、現段階のシステムを用いて実現可能なQAツールの提案を行った。提案したQAツールでは、一枚の投影画像を使用して、線量分布、線源強度、線源位置を同時に測定できるため、HDR小線源治療の迅速かつ簡単なQA法に適していると考えられる。以上の成果を論文として発表した。

  3. 放射線照射による生体分子の損傷解析と放射線治療効果モデルへの応用

    Grant number:18K07631  2018.4 - 2021.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    平野 祥之, 余語 克紀

      More details

    実験については、バイオ実験については専門外であるため、ゼロから環境を整えるのに時間を要したがDNAの電気泳動ができるようになった。研究の目的の一つとしてDNAの損傷をラマンスペクトルで特徴付けることだが、ある程度はすでに研究されており、複数の先行研究により、損傷とラマンスペクトルの関係を見つけることができた。当該研究では、まず切断箇所の様子が明確になっている制限酵素による切断のラマンスペクトルを確認しようと試みたがうまく観測できなかった。おそらく電気泳動で分離した後、該当箇所を取り出す際の手続きに問題があったと考えられる。バイオの専門家に改善策の教示を受ける予定である。またはマイクロチップ電気泳動を利用して分離後、直接分光器で観測する方法を検討している。
    一方シミュレーションについては、DNAの直接効果に加えOHラジカルによる間接効果のモデルを組み込み両方の効果を考慮した。さらに文献を参考にして酸素濃度を考慮したモデルをシミュレーションに取り入れ、DSB/SSB比について文献値とほぼ一致させることができた。これにより粒子種やLETの違いによる損傷具合の予測を調べることができる。しかしこのシミュレーションについても、多くのモデルパラメータがあり、パラメータの値の妥当性について検討しなければならない。平行して分子動力学計算をはじめたので、損傷したDNAがどのような形で安定するのかについて調べる予定である。こちらについては分子動力学の専門家の指導を受けて進めている。

  4. 蛍光ゲル線量計の開発

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

      More details

    Authorship:Coinvestigator(s) 

  5. 転移制御を目指したがん細胞特異的な新規・金属ナノ粒子による放射線併用療法の創出

    2013.4 - 2016.3

    科学研究費補助金  若手研究(B)

      More details

    Authorship:Principal investigator