Updated on 2022/08/29

写真a

 
IKEDA Yoshiki
 
Organization
Nagoya University Hospital Obstetrics and Gynecology Lecturer of hospital
Title
Lecturer of hospital
External link

Degree 2

  1. 博士(医学) ( 2022.4   名古屋大学 ) 

  2. Master of Engineering ( 2001.3   The University of Tokyo ) 

Research Interests 4

  1. Ovarian tumors

  2. Artificial intelligence

  3. 婦人科腫瘍

  4. 低侵襲手術

Research Areas 1

  1. Life Science / Obstetrics and gynecology

Current Research Project and SDGs 1

  1. 医療技能のデジタル化で実現する卵巣腫瘍の革新的診断システムの開発

Research History 4

  1. Nagoya University   Nagoya University Hospital Obstetrics and Gynecology   Lecturer of hospital

    2022.4

  2. Nagoya University   Nagoya University Hospital, Department of Obstetrics and Gynecology   Assistant Professor

    2021.4 - 2022.3

  3. Nagoya University   Nagoya University Hospital, Department of Obstetrics and Gynecology   Assistant professor of hospital

    2020.4 - 2021.3

  4. Nagoya University   Graduate School of Medicine, Department of Obstetrics and Gynecology   Designated assistant professor

    2018.2 - 2020.3

Education 3

  1. University of Fukui

    2004.10 - 2009.3

  2. The University of Tokyo

    1999.4 - 2001.3

  3. The University of Tokyo

    1995.4 - 1999.3

Professional Memberships 8

  1. 日本産科婦人科学会

  2. 日本婦人科腫瘍学会

  3. 日本産科婦人科内視鏡学会

  4. 日本婦人科ロボット手術学会

  5. 日本内視鏡外科学会

  6. 日本ロボット外科学会

  7. 日本遺伝性腫瘍学会

  8. 日本女性医学学会

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Committee Memberships 2

  1. Nature Publishing Group   Editorial Board Member, Scientific Reports  

    2022.8   

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    Committee type:Other

  2. 日本婦人科腫瘍学会   代議員  

    2022.1   

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    Committee type:Academic society

 

Papers 39

  1. Survival benefits of retroperitoneal lymphadenectomy for optimally-resected advanced ovarian high-grade serous carcinoma: a multi-institutional retrospective study Reviewed

    Ikeda Yoshiki, Yoshihara Masato, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Kajiyama Hiroaki

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 33 ( 4 ) page: e40   2022.7

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    DOI: 10.3802/jgo.2022.33.e40

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  2. Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-beta 1/thrombospondin-1 axis Reviewed

    Kitami Kazuhisa, Yoshihara Masato, Tamauchi Satoshi, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Ikeda Yoshiki, Yokoi Akira, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Nawa Akihiro, Enomoto Atsushi, Kajiyama Hiroaki

    MATRIX BIOLOGY   Vol. 109   page: 70 - 90   2022.5

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    DOI: 10.1016/j.matbio.2022.03.003

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  3. Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi-institutional retrospective study Reviewed

    Ikeda Yoshiki, Yoshihara Masato, Yoshikawa Nobuhisa, Tamauchi Satoshi, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 157 ( 2 ) page: 437 - 443   2022.5

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    DOI: 10.1002/ijgo.13844

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  4. Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis Reviewed

    Ikeda Yoshiki, Yoshihara Masato, Yoshikawa Nobuhisa, Yokoi Akira, Tamauchi Satoshi, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    BMC WOMENS HEALTH   Vol. 22 ( 1 ) page: 80   2022.3

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    DOI: 10.1186/s12905-022-01642-z

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  5. Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy Reviewed

    Uno Kaname, Yoshikawa Nobuhisa, Tazaki Akira, Ohnuma Shoko, Kitami Kazuhisa, Iyoshi Shohei, Mogi Kazumasa, Yoshihara Masato, Koya Yoshihiro, Sugiyama Mai, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Kikkawa Fumitaka, Kato Masashi, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 4513   2022.3

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    DOI: 10.1038/s41598-022-08503-7

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  6. Laparoscopic pelvic surgery after reconstructive surgery with vertical rectus abdominis muscle flap: A case report. Reviewed

    Nishino K, Ikeda Y, Kitami K, Niimi K, Kajiyama H

    International journal of surgery case reports   Vol. 90   page: 106706   2022.1

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    DOI: 10.1016/j.ijscr.2021.106706

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  7. Clinical effects of cervical conization with positive margins in cervical cancer Reviewed

    Nagao Yukari, Yokoi Akira, Yoshida Kosuke, Sumi Masanori, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 23288   2021.12

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  8. Achievement of live birth after overcoming two gynecological malignancies treated with radical trachelectomy and medroxyprogesterone acetate therapy Reviewed

    Tamauchi Satoshi, Moriyama Yoshinori, Suzuki Shiro, Ikeda Yoshiki, Yoshikawa Nobuhisa, Kajiyama Hiroaki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 4101 - 4105   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15001

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  9. Core 2 beta 1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity Reviewed

    Nakamura Kenichi, Niimi Kaoru, Yamamoto Eiko, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Kajiyama Hiroaki, Kikkawa Fumitaka

    BIOCHEMISTRY AND BIOPHYSICS REPORTS   Vol. 26   page: 100951   2021.7

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    DOI: 10.1016/j.bbrep.2021.100951

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  10. Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer Reviewed

    Yoshida Kosuke, Yoshikawa Nobuhisa, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    CANCER CELL INTERNATIONAL   Vol. 21 ( 1 ) page: 314   2021.6

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    DOI: 10.1186/s12935-021-02014-7

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  11. Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer Reviewed

    Hattori Satomi, Yoshikawa Nobuhisa, Mogi Kazumasa, Yoshida Kosuke, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kajiyama Hiroaki

    CURRENT ONCOLOGY   Vol. 28 ( 3 ) page: 1663 - 1672   2021.6

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    DOI: 10.3390/curroncol28030155

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  12. A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review Reviewed

    Nishino Kimihiro, Yamamoto Eiko, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Toshimichi, Kajiyama Hiroaki

    JOURNAL OF OVARIAN RESEARCH   Vol. 14 ( 1 ) page: 56   2021.4

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    DOI: 10.1186/s13048-021-00810-3

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  13. Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance Reviewed

    Yoshida Kosuke, Yokoi Akira, Sugiyama Mai, Oda Shingo, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Yokoi Tsuyoshi, Kajiyama Hiroaki

    ONCOGENE   Vol. 40 ( 7 ) page: 1255 - 1268   2021.2

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    DOI: 10.1038/s41388-020-01595-3

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  14. Establishment of a patient-derived xenograft model and cell line of malignant transformation of mature cystic teratoma of the ovary Reviewed

    Tamauchi Satoshi, Suzuki Shiro, Xuboya Chang, Yoshihara Masato, Yoshida Kosuke, Ikeda Yoshiki, Yoshikawa Nobuhisa, Kajiyama Hiroaki, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 2 ) page: 713 - 719   2021.2

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    DOI: 10.1111/jog.14596

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  15. A uterine pseudotumor of immunoglobulinG4-related disease Reviewed

    Senda Yasutaka, Ikeda Yoshiki, Tamauchi Satoshi, Yoshikawa Nobuhisa, Kikkawa Fumitaka, Kajiyama Hiroaki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 1 ) page: 430 - 435   2021.1

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    DOI: 10.1111/jog.14531

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  16. Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study Reviewed

    Yoshihara Masato, Tamauchi Satoshi, Iyoshi Shohei, Kitami Kazuhisa, Uno Kaname, Yoshikawa Nobuhisa, Ikeda Yoshiki, Kawai Michiyasu, Nagasaka Tetsuro, Kajiyama Hiroaki

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 254   page: 52 - 56   2020.11

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  17. Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma-activated solutions Reviewed

    Nakamura Kae, Yoshikawa Nobuhisa, Yoshihara Masato, Ikeda Yoshiki, Higashida Akihiro, Niwa Akihiro, Jindo Takahiro, Tanaka Hiromasa, Ishikawa Kenji, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

    PLASMA PROCESSES AND POLYMERS   Vol. 17 ( 10 )   2020.10

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  18. The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma Reviewed

    Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 7135   2020.4

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    DOI: 10.1038/s41598-020-64171-5

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  19. The Therapeutic Effects of Goreisan, a Traditional Japanese Herbal Medicine, on Lower-Limb Lymphedema after Lymphadenectomy in Gynecologic Malignancies: A Case Series Study Reviewed

    Yoshikawa Nobuhisa, Kajiyama Hiroaki, Otsuka Naoki, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Utsumi Fumi, Shibata Kiyosumi, Kikkawa Fumitaka

    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   Vol. 2020   page: 6298293   2020.4

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    DOI: 10.1155/2020/6298293

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  20. The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer Reviewed

    Yoshida Kosuke, Kajiyama Hiroaki, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 2 ) page: 384 - 390   2020.2

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    DOI: 10.1007/s10147-019-01551-6

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  21. Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway Reviewed

    Yoshikawa Nobuhisa, Liu Wenting, Nakamura Kae, Yoshida Kosuke, Ikeda Yoshiki, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 1614   2020.1

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    DOI: 10.1038/s41598-020-58667-3

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  22. Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age Reviewed

    Hanatani Maya, Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kawai Michiyasu, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 187 - 194   2020.1

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    DOI: 10.1007/s10147-019-01550-7

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  23. Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer Reviewed

    Yoshida Kosuke, Kajiyama Hiroaki, Inami Eri, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    IN VIVO   Vol. 34 ( 1 ) page: 109 - 116   2020

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    DOI: 10.21873/invivo.11751

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  24. Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma Reviewed

    Shimbo Akiko, Kajiyama Hiroaki, Tamauchi Satoshi, Yoshikawa Nobuhisa, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Kikkawa Fumitaka

    ONCOLOGY REPORTS   Vol. 42 ( 6 ) page: 2323 - 2332   2019.12

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    DOI: 10.3892/or.2019.7352

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  25. Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background Reviewed

    Yoshida Kosuke, Yokoi Akira, Kagawa Takumi, Oda Shingo, Hattori Satomi, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Kajiyama Hiroaki, Yokoi Tsuyoshi, Kikkawa Fumitaka

    CARCINOGENESIS   Vol. 40 ( 12 ) page: 1435 - 1444   2019.12

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    DOI: 10.1093/carcin/bgz135

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  26. COMPREHENSIVE MIRNA SEQUENCING OF SQUAMOUS CELL CARCINOMA ARISING FROM OVARIAN MATURE TERATOMA Reviewed

    Yoshida K., Yokoi A., Tamauchi S., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A544 - A545   2019.11

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    DOI: 10.1136/ijgc-2019-ESGO.1079

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  27. REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY Reviewed

    Tamauchi S., Kajiyama H., Osuka S., Moriyama Y., Yoshihara M., Iyoshi S., Yoshida K., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A269 - A270   2019.11

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    DOI: 10.1136/ijgc-2019-ESGO.469

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  28. Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study Reviewed

    Tamauchi Satoshi, Kajiyama Hiroaki, Moriyama Yoshinori, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 10 ) page: 2082 - 2087   2019.10

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    DOI: 10.1111/jog.14053

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  29. Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma Reviewed

    Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Yoshikawa Nobuhisa, Nishino Kimihiro, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 8 ) page: 950 - 956   2019.8

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    DOI: 10.1007/s10147-019-01438-6

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  30. Does postoperative prophylactic irradiation of para-aortic lymph nodes reduce the risk of recurrence in uterine cervical cancer with positive pelvic lymph nodes? Reviewed

    Yoshida K, Kajiyama H, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Utsumi F, Niimi K, Suzuki S, Kikkawa F

    International journal of clinical oncology   Vol. 24 ( 5 ) page: 567 - 574   2019.5

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    DOI: 10.1007/s10147-018-1376-2

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  31. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study Reviewed

    Tamauchi Satoshi, Kajiyama Hiroaki, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   Vol. 219 ( 4 ) page: 385.e1 - 385.e7   2018.10

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    DOI: 10.1016/j.ajog.2018.07.021

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  32. ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY Reviewed

    NIimi Kaoru, Ikeda Yoshinori, Nishino Kimihiro, Yamamoto Eiko, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E29-E29   2018.9

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  33. GENETIC STUDY ON ORIGINS OF CHORIOCARCINOMAS BY SHORT TANDEM REPEAT ANALYSIS Reviewed

    Nishino Kimihiro, Nakamura Kenichi, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Yamamoto Toshimichi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E88-E89   2018.9

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  34. CLINICAL CHARACTERISTICS OF PSTT AND ETT IN JAPAN Reviewed

    Niimi K., Yamamoto E., Nishino K., Nakamura K., Ikeda Y., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 919 - 919   2018.9

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  35. EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY ON CLINICAL OUTCOMES IN SMALL CELL CARCINOMA OF THE UTERINE CERVIX Reviewed

    Ikeda Y., Kajiyama H., Yoshida K., Yoshikawa N., Nishino K., Utsumi F., Niimi K., Suzuki S., Kawai M., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 294 - 294   2018.9

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  36. SHORT TANDEM REPEAT ANALYSIS DISTINGUISHING THE GENOTYPE OF CHORIOARCINOMA Reviewed

    Nishino K., Yamamoto E., Watanabe E., Nakamura K., Ikeda Y., Niimi K., Yamamoto T., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 920 - 920   2018.9

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  37. ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY Reviewed

    Nakamura K., Kaoru N., Ikeda Y., Nishino K., Yamamoto E., KIkkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 195 - 195   2018.9

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  38. PROPENSITY SCORE ADJUSTED ANALYSIS OF PROPHYLACTIC IRRADIATION TO PARA-AORTIC LYMPH NODE AFTER RADICAL HYSTERECTOMY FOR UTERINE CERVICAL CANCER. Reviewed

    Yoshida K., Yoshihara M., Ikeda Y., Yoshikawa N., Nishino K., Utumi F., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 447 - 447   2018.9

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  39. Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary. Reviewed

    Yoshikawa N, Teshigawara T, Ikeda Y, Nishino K, Sakata J, Utsumi F, Niimi K, Sekiya R, Suzuki S, Kawai M, Shibata K, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 44 ) page: 27564 - 27573   2018.6

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    DOI: 10.18632/oncotarget.25548

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Books 1

  1. FUSE資格者が教える電気メス

    渡邊 祐介(エネルギーデバイス用語集 フェーズ2 エディター)

    メジカルビュー社  2022.4  ( ISBN:978-4-7583-0468-9

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    Language:Japanese Book type:Scholarly book

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 医療技能のデジタル化で実現する卵巣腫瘍の革新的診断システムの開発

    Grant number:20K09667  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    池田 芳紀, 小泉 憲裕

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    本研究の目的は、医療技能のデジタル化(医デジ化)により卵巣腫瘍の革新的診断システムを開発することである。卵巣腫瘍の確定診断は手術以外には困難である。病歴、腫瘍マーカー、超音波検査、MRI、CT等の情報から、手術前に卵巣腫瘍の良・悪性や病理組織型を医師が勘や経験に基づき推定している。本研究で提案するのは、人工知能(AI)技術を用いてこの医師の技能をデジタルに再現し、術後に確定した病理組織型の情報から学習を積むことによって、人間を超える高い精度で卵巣腫瘍の良・悪性、病理組織型を術前に診断するシステムである。卵巣悪性腫瘍の早期発見手法として研究を発展させ、最終的には卵巣悪性腫瘍の死亡率低下を目指す。
    本研究の目的は、医療技能のデジタル化により、卵巣腫瘍の革新的診断システムを開発することである。卵巣腫瘍の術前診断は、既往歴、家族歴、腫瘍マーカー、超音波検査、MRI、CTなどから得られる情報を参考に、医師が良・悪性を推定している。エキスパートの画像診断医は自らカルテ上の診療情報を紐解き、卵巣腫瘍の病理組織型の推定を画像読影時に行っている。人工知能技術を用いてこの医師の技能をデジタル化し機能としてシステムに実装し、学習を積むことで、人間を超える高い診断精度を実現する。卵巣悪性腫瘍の早期発見手法として研究を発展・確立し、最終的には卵巣悪性腫瘍の死亡率減少を目指す。本研究は下記の4つのステップで卵巣腫瘍の診断システムの開発を行う。本研究期間においては1~2のステップを繰り返してシステムの性能を高め、その有効性を検証する予定である。当該年度は1の段階で最初の目標である約200症例分の診療情報、検査データの抽出を終え、画像検査データの抽出作業の途中段階である。
    1.名古屋大学産婦人科で治療した卵巣腫瘍症例の診療情報、検査データの抽出・解析;名古屋大学産婦人科で治療した卵巣腫瘍症例の患者臨床情報、血液・画像検査データ、摘出物の最終病理組織型の情報を抽出する。共同研究者のグループに集積して解析し、システムの枠組みを構築する。
    2.システムの性能の評価;上記で使用していない卵巣腫瘍症例のデータをシステムに入力し、出力された良性・境界悪性・悪性の診断と病理組織型の正診率を評価する。
    3.症例数を拡大し診断精度の向上を図る;名古屋大学産婦人科と複数の関連病院で組織する東海卵巣腫瘍研究会の登録症例へとデータの集積を拡大する。
    4.卵巣悪性腫瘍の早期発見に向けてシステムの発展・確立;一般的な検診で収集可能な臨床情報・血液検査データと経腟超音波データのみで診断を可能にし、早期発見手法として実用化を検討する。
    進捗状況としては大幅に遅れている。COVID-19の流行により当該年度のスタート時点からすでに研究活動に制限がかかっていたことが最大の原因である。当該年度は、名古屋大学産婦人科で治療した卵巣腫瘍症例の患者臨床情報、血液・画像検査データ、摘出物の最終病理組織型の情報を抽出し、共同研究者のグループに集積して解析し、システムの枠組みを構築する予定であった。まず初めに必要な作業としては、多数例の臨床情報、検査データ、画像データを匿名化して収集することである。データ収集のためには研究補助員が電子カルテシステムを参照する必要があり、施設に出勤しての作業がどうしても必要なため、テレワーク下では作業困難であった。データ収集作業が予定通りスタートできず計画より大幅に遅れを生じた。研究補助員を雇用しデータ収集作業を本格的に開始できたのが10月以降となったため、当初の計画より約半年間の遅れを生じている。当該年度は、最初の目標であった約200症例分の診療情報、検査データの抽出を終えてはいるが、画像検査データの抽出作業の途中段階であり、十分なデータ解析が行えていない。共同研究者のグループでのデータ解析・システムの枠組みの構築は次年度に繰り越して行わざるを得なくなった。
    研究計画に遅れが生じており、最初の目標であった約200症例分の診療情報、検査データの抽出を終えてはいるが、現在のところ画像検査データの匿名化・抽出作業の途中の段階である。画像検査データの抽出が終わり次第、共同研究者のグループでのデータ解析およびシステムの枠組みの構築を行う。遅れを取り戻すために、画像検査データの抽出作業のスピードを上げることも検討している。データ収集作業に携わる研究補佐員を増員すればスピードを上げることは可能であるが、人件費の増加につながる。研究計画の遅れに伴い、医用画像処理用のハードウェア・システム購入を見合わせている状況であり、この分の予算をデータ収集作業に携わる研究補佐員を増員するための費用に回すかどうか、本研究期間全体の計画を考慮しつつ今後の研究の進捗をみながら検討していく。

  2. Development of novel intraperitoneal therapy based on atmospheric pressure plasma for complete removal of peritoneal dissemination

    Grant number:19K21346  2019.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity Start-up

    Ikeda Yoshiki

      More details

    Authorship:Principal investigator 

    Grant amount:\2990000 ( Direct Cost: \2300000 、 Indirect Cost:\690000 )

    Anti-tumor effects of plasma-activated medium (PAM) on endometrial cancer remain unknown. Our results demonstrated that PAM inhibited cell viabilities by inducing autophagic cell death in endometrial cancer cells. We investigated the inhibitory effect of PAM on the viabilities of endometrial cancer cells in vitro. Our data showed that the viabilities of AMEC and HEC50 endometrial cancer cell lines were decreased by PAM at a certain PAM ratio, and PAM treatment effectively increased autophagic cell death in a concentration dependent manner. In addition, we evaluated the molecular mechanism of PAM activity and found that PAM treatment in both HEC1A and HEC50 endometrial cancer cells increased the protein expression of LC3B which is a biomarker of autophagy.

 

Teaching Experience (On-campus) 2

  1. 現代医療と生命科学

    2021

  2. 産婦人科学

    2021