Papers - MORIOKA Hiroshi

Healthcare-associated infections in Japanese hospitals: results from a large-scale multicentre point-prevalence survey in Aichi, 2020 Invited Reviewed

Hiroshi Morioka, Yusuke Koizumi, Keisuke Oka, Masami Okudaira, Yuka Tomita, Yumi Kojima, Toshitaka Watariguchi, Koichi Watamoto, Yoshikazu Mutoh, Takeshi Tsuji, Manabu Yokota, Junichi Shimizu, Chihiro Hasegawa, Susumu Iwata, Masatoshi Nagaoka, Yuji Ito, Shohei Kawasaki, Hiroki Kato, Yuichi Kitagawa, Takuya Goto, Yasuhiro Nozaki, Kenji Akita, Shinsuke Shimizu, Masanori Nozawa, Munehiro Kato, Masamitsu Ishihara, Kenta Ito, Tetsuya Yagi

Infection Control and Hospital Epidemiology     2024

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Appropriateness of surgical antimicrobial prophylaxis in Japanese university hospitals. Reviewed International journal

Hiroshi Morioka, Hiroki Ohge, Miki Nagao, Hideaki Kato, Ryohei Kokado, Koichi Yamada, Takahiro Yamada, Nobuyuki Shimono, Yoko Nukui, Shingo Yoshihara, Ippei Sakamaki, Kisato Nosaka, Yuko Kubo, Hideki Kawamura, Yuji Fujikura, Tsuyoshi Kitaura, Mitsuhiro Sunakawa, Tetsuya Yagi

The Journal of hospital infection     2022.7

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OBJECTIVE: This study aimed to determine the adherence to the Japanese surgical antimicrobial prophylaxis (SAP) guidelines in Japanese university hospitals. DESIGN: A retrospective cohort study. SETTING: Fifteen general and one dental university hospitals. METHODS: We evaluated up to three cases of 18 designated surgeries regarding adherence to Japanese SAP guidelines: selection of antibiotics, timing of administration, re-dosing intervals, and duration of SAP. When all items were appropriate, surgery was defined as 'appropriate.' RESULTS: In total, 688 cases (22-45 cases per surgery) were included. The overall appropriateness was 46.8% (322/688), and the appropriateness of each surgery ranged from 8.0% (2/25, cardiac implantable electronic device implantation) to 92.1% (35/38, distal gastrectomy). The appropriateness of each item was as follows: pre/intraoperative selections, 78.5% (540/688); timing of administrations, 96.0% (630/656); re-dosing intervals, 91.8% (601/656); postoperative selection, 78.9% (543/688); and duration of SAP, 61.4% (423/688). The overall appropriateness of hospitals ranged from 17.6% (9/51) to 73.3% (33/45). The common reasons for inappropriateness were the longer duration (38.5%, 265/688) and choice of antibiotics with a non-optimal antimicrobial spectrum before/during, and after surgery (19.0%, 131/688 and 16.8%, 116/688, respectively), compared to the guideline. CONCLUSIONS: Adherence to the guidelines differed greatly between the surgeries and hospitals. Large-scale multicentre surveillance of SAP in Japanese hospitals is necessary to identify inappropriate surgeries, factors related to the appropriateness, and incidences of surgical site infections.

DOI： 10.1016/j.jhin.2022.06.017

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The first multi-centre point-prevalence survey in four Japanese university hospitals Reviewed

Morioka H., Nagao M., Yoshihara S., Ohge H., Kasahara K., Shigemoto N., Kajihara T., Mori M., Iguchi M., Tomita Y., Ichiyama S., Yagi T.

JOURNAL OF HOSPITAL INFECTION   Vol. 99 ( 3 ) page： 325-331   2018.7

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jhin.2018.03.005

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Re-evaluation of blood culture contamination rates: Discordance between clinical and laboratory assessment Invited Reviewed

Hiroshi Hamada, Hiroshi Morioka, Masaki Okazaki, Atsushi Hashizume, Kohei Kanda, Keisuke Oka, Mitsutaka Iguchi, Tetsuya Yagi

Journal of Infection and Chemotherapy   Vol. 31 ( 4 )   2025.1

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jiac.2025.102628

Reducing infectious complications and healthcare costs in transrectal ultrasound-guided prostate biopsy with single-dose cefmetazole and levofloxacin Invited Reviewed

Katsuhiro Onishi, Hiroshi Morioka, Kazuki Nishida, Masashi Yamamoto, Daisuke Tsuchimoto, Yoshie Moriya, Osamu Kamihira

Urologic Oncology: Seminars and Original Investigations     2025

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Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.urolonc.2025.01.017

Flavonifractor plautii bacteremia following bacterial translocation from the gut: A case report and literature review Invited Reviewed

Yukari Osada, Keisuke Oka, Mitsutaka Iguchi, Hiroshi Morioka, Ken-Ichi Iwata, Moeko Ohara, Nami Shimaoka, Tsunaki Sawada, Tetsuya Yagi

Journal of Infection and Chemotherapy   Vol. 31 ( 3 )   2024.12

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Language：English  

DOI： 10.1016/j.jiac.2024.12.021

Risk factors for cefmetazole-non-susceptible bacteremia in acute cholangitis Reviewed

Katsuhiro Onishi, Hiroshi Morioka, Takahiro Imaizumi, Daisuke Tsuchimoto, Mitsuru Nishio, Takuma Komiyama

Journal of Infection and Chemotherapy     2024.2

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DOI： 10.1016/j.jiac.2023.11.015

Surgical antimicrobial prophylaxis in Japanese hospitals: Real status and challenges Reviewed

Hiroshi Morioka, Yusuke Koizumi, Toshitaka Watariguchi, Keisuke Oka, Yuka Tomita, Yumi Kojima, Masami Okudaira, Yuji Ito, Junichi Shimizu, Koichi Watamoto, Hiroki Kato, Masatoshi Nagaoka, Manabu Yokota, Chihiro Hasegawa, Takeshi Tsuji, Shinsuke Shimizu, Kenta Ito, Shohei Kawasaki, Kenji Akita, Yuichi Kitagawa, Yoshikazu Mutoh, Masamitsu Ishihara, Susumu Iwata, Yasuhiro Nozaki, Masanori Nozawa, Munehiro Kato, Masao Katayama, Tetsuya Yagi ; Research Group of Aichi Point Prevalence Survey

Journal of Infection and Chemotherapy     2024.1

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Authorship：Lead author,　Corresponding author   Language：English  

DOI： 10.1016/j.jiac.2024.01.013.

Other Link： https://www.sciencedirect.com/science/article/pii/S1341321X24000230?via%3Dihub

Peritonsillar abscess caused by Mycoplasma hominis and Fusobacterium necrophorum following oral sex Invited Reviewed

Hiroshi Morioka, Hideyuki Kaida, Mitsuru Nishio, Kenji Suga

Auris Nasus Larynx     2024.1

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2023.10.004

Catheter-related bloodstream infection caused by Lacticaseibacillus paracasei: A case report and literature review Reviewed

Yuto Fukuda Hiroshi Morioka, Shuta Yamamoto, Mitsutaka Iguchi, Shinichi Umeda, Takashi Asahara, Kohei Kanda, Keisuke Oka, Goro Nakayama, Tetsuya Yagi

Journal of Infection and Chemotherapy     2024.1

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DOI： 10.1016/j.jiac.2023.12.015.

Other Link： https://www.sciencedirect.com/science/article/pii/S1341321X24000023?via%3Dihub

A case of invasive rhinosinusitis caused by Penicillium brasilianum Invited Reviewed

Yuki Hirao, Hiroshi Morioka, Shinya Ozaki, Makoto Kawachi, Sayaka Ban, Takashi Yaguchi, Akira Watanabe

Medical Mycology Journal     2024

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Bacteraemia and obstructive pyelonephritis caused by Bifidobacterium breve in an elderly woman: a case report and literature review Invited Reviewed

Nishio M , Morioka H , Takai S , Seki Y , Osugi T , Oba A , Miyaki Y

Access Microbiology     2023.10

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Hypopharyngeal Injury by Transesophageal Echocardiography During Cardiac Surgery Invited Reviewed

Yohei Aoki, Takahiro Tamura, Wataru Uchida, Hiroshi Morioka, Mayumi Yamamoto, Satoshi Yuhara, Naoki Nishio, Masato Mutsuga, Satoshi Furune, Shogo Suzuki, Kimitoshi Nishiwaki

J Cardiothorac Vasc Anesth   Vol. 37 ( 10 ) page： 2027 - 2031   2023.10

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Language：English   Publishing type：Research paper (scientific journal)  

Syphilis Showing Multiple Pulmonary Nodules Without Respiratory Symptoms Invited Reviewed

Yuki Arisawa, Kyoko Sugawara, Hiroshi Morioka, Kazuto Takada

Internal Medicine     2023.8

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2169/internalmedicine.1754-23

Current Status of Outpatient Oral Antimicrobial Prescription and the Influence of Antimicrobial Stewardship for Inpatients: A Repeated Cross-Sectional Study at a Japanese Community Hospital

Tsuchimoto Daisuke, Morioka Hiroshi, Imaizumi Takahiro, Miyagawa Sawako, Yamamoto Masashi, Onishi Katsuhiro, Kuwabara Yukinori, Takada Kazuto, Watamoto Koichi

BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 45 ( 9 ) page： 1340 - 1346   2022.9

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Lysinibacillus fusiformis bacteremia: Case report and literature review. International journal

Hiroshi Morioka, Keisuke Oka, Yosuke Yamada, Yoshimasa Nakane, Hitoshi Komiya, Chiaki Murase, Mitsutaka Iguchi, Tetsuya Yagi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 28 ( 2 ) page： 315 - 318   2022.2

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Language：Japanese   Publishing type：Research paper (scientific journal)  

A 93-year-old woman was diagnosed with Lysinibacillus fusiformis bacteremia complicated with coma blisters. Initial gram staining for L. fusiformis indicated the presence of gram-negative rods; however, subsequent staining of colonies from Mueller-Hinton agar revealed the presence of gram-positive and gram-negative rods with spherical endospores, and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (VITEK ® MS and microflex® LT/SH) definitively identified the organism as L. fusiformis. The two-week administration of piperacillin/tazobactam and ampicillin resulted in an improvement of the patient's general condition, and the skin lesions gradually improved.

DOI： 10.1016/j.jiac.2021.10.030

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A case of facial skin ulcer caused by Mycolicibacterium mageritense after tennis ball bruising. International journal

Yu Sando, Hiroshi Morioka, Kyoko Sugawara, Yuki Arisawa, Hanako Fukano, Yoshihiko Hoshino

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   Vol. 114   page： 55 - 57   2022.1

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.ijid.2021.10.042

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Five-year point prevalence survey of healthcare-associated infections and antimicrobial use in a Japanese university hospital Reviewed

Hiroshi MORIOKA, Mitsutaka IGUCHI, Nobuyuki TETSUKA, Fumie KINOSHITA, Yuka TOMITA, Daizo KATO, Aki HIRABAYASHI, Akane MATSUMOTO, Keisuke OKA, Hiroki KATO, Takayuki INAGAKI, Yoshiaki KATO, Kanako KITAGAWA, Kazuya ICHIKAWA, Yuichi KOUYAMA, Naoko KAWAMURA, Yuka TOYODOME, Nagisa ADACHI, Yoshinori ITO, and Tetsuya YAGI

Infection Prevention in Practice   Vol. 3 ( 3 )   2021.9

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Other Link： https://pubmed.ncbi.nlm.nih.gov/34647007/

A Case Report of Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense.

Oka K, Morioka H, Eguchi M, Sato Y, Tetsuka N, Iguchi M, Kanematsu T, Fukano H, Hoshino Y, Kiyoi H, Yagi T

Internal medicine (Tokyo, Japan)     2021.3

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Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本内科学会  

<p>We herein report a 59-year-old woman with a 2-year history of chronic bursitis of the hand who took 50 mg/day prednisolone for several autoimmune diseases. <i>Mycobacteroides abscessus</i> subsp. <i>massiliense</i> was isolated from the abscess and blood culture. Combination therapy (imipenem/cilastatin, amikacin, and clarithromycin) was administered for a month. Two months later, <i>M. massiliense</i> was detected from a blood culture again, and disseminated lesions were found. Clarithromycin and sitafloxacin were administered following eight weeks of the same regimen. Six months after the diagnosis, <i>M. massiliense</i> was isolated from a blood culture, and she expired due to multiple organ failure. </p>

DOI： 10.2169/internalmedicine.6189-20

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Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia.

Akihiro Ryuge, Shoji Saito, Hiroshi Morioka, Asaka Hachiya, Noritoshi Kato, Takuji Ishimoto, Tomoki Kosugi, Shoichi Maruyama

Internal medicine (Tokyo, Japan)   Vol. 60 ( 5 ) page： 761 - 764   2021

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Internal Medicine  

Nontyphoidal Salmonella is a common cause of bacterial gastroenteritis, occasionally causing bacteremia. We herein report the case of an 80-year-old man who presented with bacteremia and pre-renal acute kidney injury (AKI) secondary to diarrhea caused by nontyphoidal Salmonella. Despite AKI improvement on fluid administration, some serological abnormalities, such as hypokalemia, hypophosphatemia, and hypouricemia, and abnormal urinary findings emerged, including renal glycosuria and aminoaciduria. Fractional excretion of phosphate and uric acid was increased, suggesting that the serological and urinary abnormalities may have arisen from Fanconi syndrome. Physicians should consider acquired Fanconi syndrome when patients with nontyphoidal Salmonella bacteremia present with electrolyte disorders.

DOI： 10.2169/internalmedicine.5932-20

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Fungal endocarditis after transcatheter aortic valve replacement (TAVR): Case report and review of literature. International journal

Hiroshi Morioka, Yoshiyuki Tokuda, Hideki Oshima, Mitsutaka Iguchi, Yuka Tomita, Akihiko Usui, Tetsuya Yagi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 25 ( 3 ) page： 215 - 217   2019.3

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The reported number of transcatheter aortic valve replacement-associated infective endocarditis (TAVR-IE) cases has been increasing worldwide, but information about the incidence and clinical features of fungal TAVR-IE is quite limited. We present a patient who acquired TAVR-IE caused by Candida parapsilosis four month after TAVR, who was successfully treated redo-aortic valve replacement and prolonged antifungal therapy.

DOI： 10.1016/j.jiac.2018.08.017

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Active surveillance in response to the identification of a single carbapenemase-producing Escherichia coli at a Japanese university hospital. International journal

Daizo Kato, Hiroshi Morioka, Yuka Tomita, Mitsutaka Iguchi, Aki Hirabayashi, Noriyuki Tetsuka, Takuya Sadomoto, Miyuki Hyodo, Mariko Mochizuki, Yukari Osada, Masato Yamamoto, Yoshiaki Kato, Takayuki Inagaki, Kazuya Ichikawa, Tetsuya Yagi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 24 ( 12 ) page： 1013 - 1015   2018.12

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Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

This report described the experience of active surveillance culture implemented in response to the identification of a single carbapenemase-producing Escherichia coli in a Japanese university hospital. It revealed a horizontal transmission event and an additional asymptomatic carrier of carbapenemase-producing Escherichia coli with unique drug susceptibility and resistance gene profiles. Early implementation of active surveillance culture as a part of multifaceted infection control measures appeared to be useful to control further transmission of carbapenemase-producing Escherichia coli even in the low endemic facility. Further investigations on the timing and usefulness of active surveillance culture in the control of carbapenemase-producing Enterobacteriaceae would be warranted.

DOI： 10.1016/j.jiac.2018.05.013

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Risk factors for and role of OprD protein in increasing minimal inhibitory concentrations of carbapenems in clinical isolates of Pseudomonas aeruginosa

Hirabayashi Aki, Kato Daizo, Tomita Yuka, Iguchi Mitsutaka, Yamada Keiko, Kouyama Yuichi, Morioka Hiroshi, Tetsuka Nobuyuki, Yagi Tetsuya

JOURNAL OF MEDICAL MICROBIOLOGY   Vol. 66 ( 11 ) page： 1562 - 1572   2017.11

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1099/jmm.0.000601

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Appropriateness of surgical prophylaxis contributed to significant reduction of oral cephalosporins in a Japanese university hospital

Hiroshi Morioka, Yoshiaki Kato, Takayuki Inagaki, Nobuyuki Tetsuka, Mitsutaka Iguchi, Yuka Tomita, Tetsuya Yagi

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 50   page： S42 - S43   2017.11

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

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Recurrent bacteremia and liver abscess caused by Clostridium difficile A case report

Morioka Hiroshi, Iguchi Mitsutaka, Kuzuya Teiji, Mikamo Hiroshige, Yagi Tetsuya

MEDICINE   Vol. 96 ( 35 ) page： e7969   2017.9

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/MD.0000000000007969

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Pneumococcal biliary tract infections - How rare are they?

Morioka Hiroshi, Iguchi Mitsutaka, Oodate Mitsuru, Yoneda Masaki, Ushijima Futoshi, Hirabayashi Aid, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yagi Tetsuya

JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 23 ( 6 ) page： 415 - 418   2017.6

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DOI： 10.1016/j.jiac.2016.11.008

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A case of sepsis caused by intra abdominal infection with Mycoplasma hominis after Caesarean section

  Vol. 27 ( 1 ) page： 23 - 28   2017

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デバイス関連感染症の予防 (特集 感染症対策update : ひろげない,ふやさない,もらわない) -- (病原体をひろげないための方策)

森岡 悠, 井口 光孝

内科   Vol. 118 ( 5 ) page： 885 - 889   2016.11

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Publishing type：Research paper (scientific journal)   Publisher：南江堂  

The first point prevalence survey of health care-associated infection and antimicrobial use in a Japanese university hospital: A pilot study. International journal

Hiroshi Morioka, Aki Hirabayashi, Mitsutaka Iguchi, Yuka Tomita, Daizo Kato, Naokazu Sato, Miyuki Hyodo, Naoko Kawamura, Takuya Sadomoto, Kazuya Ichikawa, Takayuki Inagaki, Yoshiaki Kato, Yuichi Kouyama, Yoshinori Ito, Tetsuya Yagi

American journal of infection control   Vol. 44 ( 7 ) page： E119 - E123   2016.7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MOSBY-ELSEVIER  

BACKGROUND: Point prevalence surveys (PPSs) in Japanese hospitals have not yet been reported. The purpose of this pilot PPS study was to evaluate the epidemiology of health care-associated infections (HAIs) and antimicrobial use in a Japanese tertiary university hospital. METHODS: A 1-day, cross-sectional PPS was performed at a Japanese university hospital. Data on demographics, active HAIs, and antimicrobial use of all inpatients were collected using a data collection form. RESULTS: Of 841 patients, 85 (10.1%) had 90 active HAIs, and 308 patients (36.6%) were administered 494 antimicrobials. Among the 90 HAIs and 58 pathogens, the most frequent infection and isolated pathogen were pneumonia (20.0%) and Enterobacteriaceae (27.6%), respectively. Of the 118 antimicrobials used for treatment of HAIs, carbapenems were the most frequently administered category of antimicrobials (22.9%). In regard to antimicrobials for surgical prophylaxis, 37 of 119 (31.1%) were administered to patients on postoperative day 3 or later, and 48 of 119 (40.3%) were administered orally. CONCLUSIONS: The incidence of HAIs is higher than in other developed countries. The social and medical situation in Japan may affect patient demographics, active HAIs, and antimicrobial use. Multicenter PPSs are necessary to uncover the real epidemiology of HAIs and antimicrobial use in Japan.

DOI： 10.1016/j.ajic.2016.03.045

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CD8 Encephalitis Caused by Persistently Detectable Drug-resistant HIV.

Hiroshi Morioka, Naoki Yanagisawa, Shugo Sasaki, Noritaka Sekiya, Akihiko Suganuma, Akifumi Imamura, Atsushi Ajisawa, Shuji Kishida

Internal medicine (Tokyo, Japan)   Vol. 55 ( 10 ) page： 1383 - 1386   2016

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We herein report a 52-year-old man infected with human immunodeficiency virus (HIV) who was referred to our hospital due to the development of severe neurocognitive disorders and bilateral leukoencephalopathy. He has been treated with antiretroviral agents for 17 years, but low-level viremia has been detected consistently prior to admission. Drug resistant testing of the serum and the cerebrospinal fluid (CSF) both demonstrated a M184V mutation. A brain biopsy revealed perivascular CD8(+) T-lymphocyte infiltration, leading to the diagnosis of CD8 encephalitis. The clinical symptoms improved drastically after changing to a nucleoside reverse transcriptase inhibitor sparing regimen, which subsequently decreased the HIV viral load to an undetectable level in both the serum and CSF.

DOI： 10.2169/internalmedicine.55.5783

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Laryngeal Kaposi's Sarcoma Complicated by the Immune Reconstitution Inflammatory Syndrome in an HIV-infected Patient.

Hirofumi Kato, Naoki Yanagisawa, Hiroshi Morioka, Shugo Sasaki, Noritaka Sekiya, Akihiko Suganuma, Akifumi Imamura, Atsushi Ajisawa

Internal medicine (Tokyo, Japan)   Vol. 55 ( 8 ) page： 1001 - 1005   2016

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We herein report a case of laryngeal Kaposi's sarcoma (KS) complicated by immune reconstitution inflammatory syndrome in a human immunodeficiency virus (HIV)-infected patient. The patient initially presented with KS involving the larynx, which was successfully treated with pegylated liposomal doxorubicin (PLD) and antiretroviral therapy (ART). PLD was discontinued after 2 courses because of a marked clinical improvement; however, the patient experienced progressive odynophagia and dyspnea 2 months after the initiation of ART. Laryngoscopy revealed a severely swollen, inflamed epiglottis. The readministration of PLD was successful, and the patient was thereafter discharged without any subsequent complications.

DOI： 10.2169/internalmedicine.55.5813

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Disseminated Mycobacterium abscessus Infection Following Septic Arthritis: A Case Report and Review of the Literature. International journal

Shoichi Fukui, Noritaka Sekiya, Yasunobu Takizawa, Hiroshi Morioka, Hirofumi Kato, Akio Aono, Kinuyo Chikamatsu, Satoshi Mitarai, Satomi Kobayashi, Satoshi Kamei, Keigo Setoguchi

Medicine   Vol. 94 ( 21 ) page： e861   2015.5

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Mycobacterium abscessus is a rapidly growing mycobacterium found mainly in patients with respiratory or cutaneous infections, but it rarely causes disseminated infections. Little is known about the clinical characteristics, treatment, and prognosis of disseminated M abscessus infection. A 75-year-old Japanese woman who had been treated for 17 years with a corticosteroid for antisynthetase syndrome with antithreonyl-tRNA synthetase antibody developed swelling of her right elbow. X-ray of her right elbow joint showed osteolysis, and magnetic resonance imaging revealed fluid in her right elbow joint. M abscessus grew in joint fluid and blood cultures. She was diagnosed with a disseminated M abscessus infection following septic arthritis. Antimicrobial treatment by clarithromycin, amikacin, and imipenem/cilastatin combined with surgical debridement was administered. Although blood and joint fluid cultures became negative 1 week later, the patient died at 6 weeks from starting antimicrobial treatment. We reviewed 34 cases of disseminated M abscessus infections from the literature. Most of the patients had immunosuppressive backgrounds such as transplantation, use of immunosuppressive agents, hematological malignancy, and end stage renal disease. The duration from onset of symptoms to diagnosis was over 3 months in half of the cases. All fatal cases had positive blood cultures or use of immunosuppressive agents. Clinicians should bear in mind that mycobacterial infections including M abscessus are one of the differential diagnoses in patients with subacute arthritis and soft tissue infections.

DOI： 10.1097/MD.0000000000000861

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A型肝炎ワクチン(エイムゲンとHavrix)接種後の抗体価と互換性に関する検討

菊池 均, 宮津 光伸, 永田 俊人, 後藤 泰浩, 山本 悦子, 森岡 悠, 佐藤 好隆

日本渡航医学会誌 = Journal of the Japanese Society of Travel and Health   Vol. 9 ( 1 ) page： 48 - 50   2015

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Publishing type：Research paper (scientific journal)   Publisher：日本渡航医学会  

P0578-22-AM 注射用抗菌薬届出システムの構築と適正使用に向けた介入方法の検討(感染制御(その他)1,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-)

加藤 善章, 八木 哲也, 山田 清文, 山本 雅人, 稲垣 孝行, 手塚 宜行, 森岡 悠, 平林 亜希, 井口 光孝, 加藤 大三, 冨田 ゆうか

日本医療薬学会年会講演要旨集   Vol. 25 ( 0 )   2015

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Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本医療薬学会  

DOI： 10.20825/amjsphcs.25.0_362_2

Evaluation of HIV-infected Patients Suspected as Having HIV-associated Neurocognitive Disorders

MORIOKA Hiroshi, KISHIDA Shuji, IMAMURA Akifumi, SEKIYA Noritaka, YANAGISAWA Naoki, SUGANUMA Akihiko, AJISAWA Atsushi

Kansenshogaku Zasshi   Vol. 88 ( 2 ) page： 141 - 8   2014.3

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Publishing type：Research paper (scientific journal)   Publisher：The Japanese Association for Infectious Diseases  

Background：HIV-associated neurocognitive disorders (HAND) have emerged as a problem among HIV-infected individuals in the era of antiretroviral therapy. However, there are insufficient data on HAND regarding its prevalence and clinical features in Japan. Methods：A test battery composed of eight neuropsycological tests proposed by the Ministry of Health,Labour and Welfare (MHLW test battery) was applied to assess 30 subjects at Tokyo Metropolitan Komagome Hospital. Among them, 5 subjects were excluded due to central nervous system complications. The background of each patient along with the results of head magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and neuropsychological tests were compared to each HAND category. In addition, the clinical utility of a combination of neuropsychological tests as an abbreviated test battery of HAND was evaluated. Results：A total of 19 (76％) subjects were diagnosed as having a HAND. Among them, HIV-associated dementia, mild neurocognitive disorders and asymptomatic neurocognitive disorders were diagnosed in 7, 8,and 4 subjects, respectively. Neither the patientʼs background nor the results of the head MRI and CSF analysis showed relevance to disease severity. The conventional International HIV Dementia Scale with the Digit Symbol Substitute Test was capable of detecting 94.7％cases of HAND. Conclusions：Most HIV-infected subjects clinically suspected as having neurocognitive disorders were diagnosed as having a HAND. Neuropsychological tests of the MHLW test battery were in some part useful to diagnose HAND. However, more precise neuropsychological tests are warranted to screen and diagnose HAND, based on the current criteria.

DOI： 10.11150/kansenshogakuzasshi.88.141

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Bilateral Facial Nerve Palsy and Appendicitis Occurring during Acute Retroviral Syndrome

Morioka Hiroshi, Sakamoto Naoya, Iwabuchi Sentaro, Ohnishi Kenji

INTERNAL MEDICINE   Vol. 53 ( 2 ) page： 155 - 158   2014

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Publishing type：Research paper (scientific journal)   Publisher：Internal Medicine  

We herein report the case of 41-year-old homosexual man who presented to our hospital with typical acute retroviral syndrome. Complications of bilateral facial nerve palsy and appendicitis appeared eight days after admission. The bilateral facial nerve palsy spontaneously recovered one month later; however, the appendicitis required surgical intervention. To our knowledge, this is the first reported case of appendicitis related to acute retroviral syndrome.<br>

DOI： 10.2169/internalmedicine.53.0636

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PubMed

神経心理検査で改善が示唆されたHIV-associated dementiaの1例

森岡 悠, 今村 顕史

HIV感染症とAIDSの治療   Vol. 5 ( 1 ) page： 46 - 48   2014

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Publishing type：Research paper (scientific journal)   Publisher：メディカルレビュー社  

Necrotizing Fasciitis after a Cat Bite : A Case Report

HOSODA Tomohiro, YANAGISAWA Naoki, MORIOKA Hiroshi, SUGANUMA Akihiko, IMAMURA Akifumi, AJISAWA Atsushi

Kansenshogaku Zasshi   Vol. 87 ( 2 ) page： 211 - 4   2013.3

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Publishing type：Research paper (scientific journal)   Publisher：The Japanese Association for Infectious Diseases  

We report on a previously healthy 56-year-old woman who was referred to our hospital with fever and progressive left foot pain. She had been bitten by a cat 7 days previously, and cephalosporins had been prescribed for treatment. However, her clinical symptoms deteriorated, and physical examination on admission was compatible with necrotizing fasciitis. Treatment with ampicillin-sulbactam and clindamycin was initiated. In addition, immediate surgical debridement was performed, resulting in therapeutic success. Culture of the necrotizing tissue grew multiple organisms, including <i>Pasteurella multocida</i> and <i>Bacteroides caccae</i>. Administration of appropriate antibiotics after a cat bite is essential for the prevention of potentially fatal complications.

DOI： 10.11150/kansenshogakuzasshi.87.211

PubMed

Re-expansion pulmonary edema: evaluation of risk factors in 173 episodes of spontaneous pneumothorax. International journal

Hiroshi Morioka, Kazuto Takada, Shuuichi Matsumoto, Eiji Kojima, Susumu Iwata, Shoutaro Okachi

Respiratory investigation   Vol. 51 ( 1 ) page： 35 - 9   2013.3

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Publishing type：Research paper (scientific journal)  

BACKGROUND: The precise incidence and clinical features of re-expansion pulmonary edema (RPE) are unclear, and they vary among reports. In this study, we assessed the incidence, risk factors, and outcomes of patients with RPE over a 3-yr period in a general hospital, with the goal of proposing a primary intervention for pneumothorax. METHODS: We retrospectively reviewed records of inpatients with spontaneous pneumothorax treated by tube thoracostomy between October 2007 and December 2010. RESULTS: A total of 173 episodes of spontaneous pneumothorax occurred in 156 patients. The incidence of RPE was 27/173 (15.6%). Symptom duration and pneumothorax size were significant risk factors for RPE, and the occurrence of RPE was independent of primary treatment of spontaneous pneumothorax. Among the patients with RPE, 18 (67%) were symptomatic. Five patients (18.5%) were treated with temporary oxygen, however, 21 patients (78%) did not need any treatment. All patients survived and none required mechanical ventilation. The occurrence of RPE did not influence the clinical outcome. CONCLUSIONS: The risk of developing RPE increases with an increased duration or size of pneumothorax. Our results suggest that the methods of primary intervention, including prompt suction, do not affect the onset of RPE. Close observation is always required regardless of the intervention because of the potentially fatal complications.

DOI： 10.1016/j.resinv.2012.09.003

PubMed

Bilateral Emphysematous Pyelonephritis with a Splenic Abscess

Morioka Hiroshi, Yanagisawa Naoki, Suganuma Akihiko, Imamura Akifumi, Ajisawa Atsushi

INTERNAL MEDICINE   Vol. 52 ( 1 ) page： 147 - 150   2013

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Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本内科学会  

The case of a 66-year-old woman with untreated diabetes mellitus who was admitted to our hospital with a fever, hypotension and an altered mental status is herein reported. Computed tomography revealed bilateral emphysematous pyelonephritis along with a splenic abscess. Blood and urine cultures grew <i>Escherichia coli.</i> Treatment with systemic antibiotics combined with the insertion of percutaneous and renoureteral catheters was successful. The patient was discharged and completed treatment without developing any subsequent complications.<br>

DOI： 10.2169/internalmedicine.52.8302

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PubMed

Paradoxical Infarct in Tuberculous Meningitis: A Case Report

Morioka Hiroshi, Matsumoto Shuuichi, Kojima Eiji, Takada Kazuto, Iwata Susumu, Okachi Shoutaro

INTERNAL MEDICINE   Vol. 51 ( 8 ) page： 949 - 951   2012

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Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本内科学会  

We describe a case of 78-year-old woman with a 1-week history of fever and left hemiparesis. Head magnetic resonance imaging showed a small infarct. After admission, she showed altered consciousness and another small infarct. She finally had diagnoses of miliary tuberculosis (miliary-TB) and tuberculous meningitis (TBM). She recovered after receiving anti-tuberculous therapy (ATT) with prednisolone. However, 5 weeks later, we found another infarct. This is a rare case of TBM with recurrent infarcts in atypical lesions in spite of ATT. We suggest the possibility that the new infarct after ATT was due to a paradoxical reaction.<br>

DOI： 10.2169/internalmedicine.51.6830

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PubMed

Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire. International journal

Kazuto Takada, Shuuichi Matsumoto, Eiji Kojima, Susumu Iwata, Shoutarou Okachi, Kiyoko Ninomiya, Hiroshi Morioka, Kentarou Tanaka, Yasunori Enomoto

Respiratory medicine   Vol. 105 ( 10 ) page： 1531 - 1536   2011.10

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BACKGROUND: Little is known about the relationship between acute exacerbations of COPD (AECOPD) and gastroesophageal reflux disease (GERD). The aim of this study was to investigate the effects on AECOPD of GERD diagnosed by a questionnaire. METHODS: The subjects were 221 consecutive patients with stable COPD who were evaluated using the Frequency Scale for Symptoms of GERD (FSSG) and a prospective survey of AECOPD for one year. Patients taking drugs for acid suppression were excluded. The association between the frequency of AECOPD and the presence of GERD or FSSG score was examined. RESULTS: Based on the FSSG, the prevalence of GERD was 26.7%. AECOPD and hospitalization due to AECOPD were significantly more frequent in patients with GERD than in those without GERD, with crude relative risks of 3.42 and 3.66, respectively. Multivariate analyses showed that GERD and COPD stage IV were significant predictors of hospitalization due to AECOPD, independent of respiratory therapies or patient characteristics. The severity of GERD symptoms, as measured by the FSSG score, was significantly correlated with the frequencies of AECOPD and hospitalization due to AECOPD. Similar correlations were seen for the FSSG subscores for acid reflux and gastric dysmotility. CONCLUSIONS: This prospective cohort study showed that GERD appears to be a predictive factor for hospitalization due to AECOPD and that severer GERD symptoms may be associated with more frequent AECOPD. Thus, further studies are warranted to evaluate the preventive effect of the therapy for GERD on AECOPD.

DOI： 10.1016/j.rmed.2011.03.009

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PubMed

Case report: A case of pneumocystis pneumonia after etanercept therapy

  Vol. 108 ( 3 ) page： 555 - 557   2011.9

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Publishing type：Research paper (scientific journal)  

A case of fulminant community-acquired Acinetobacter pneumonia in a healthy woman

MORIOKA Hiroshi, MATSUMOTO Shuuichi, KOJIMA Eiji, TAKADA Kazuto, SHIZU Masato, OKACHI Shoutarou

  Vol. 49 ( 1 ) page： 57 - 61   2011.1

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Publishing type：Research paper (scientific journal)  

[A case of fulminant community-acquired Acinetobacter pneumonia in a healthy woman].

Morioka H, Matsumoto S, Kojima E, Takada K, Shizu M, Okachi S

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society   Vol. 49 ( 1 ) page： 57 - 61   2011.1

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[A case of fulminant community-acquired Acinetobacter pneumonia in a healthy woman].

Morioka H., Matsumoto S., Kojima E., Takada K., Shizu M., Okachi S.

Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society   Vol. 49 ( 1 ) page： 57 - 61   2011.1

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society  

We describe a case of fulminant community-acquired Acinetobacter baumannii pneumonia. A 68-year-old woman, who had no past medical history, was admitted with septic shock and pneumonia of left lower lobe. Despite intensive treatment she died on day 3 after admission. To the best of our knowledge, this is the 4th report of community-acquired Acinetobacter pneumonia in Japan and the 1st report in a healthy patient. We report a case of Acinetobacter pneumonia and discuss the clinical characteristics of the community-acquired type compared with the hospital-acquired type.

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P2-09-3 FeNO高値の気管支喘息患者に対するブデゾニド/ホルモテロール配合薬による薬物療法の効果と安全性(P2-09 成人喘息5,ポスターセッション,第23回日本アレルギー学会春季臨床大会)

岩田 晋, 後藤 大揮, 清水 隆宏, 松本 修一, 小島 英嗣, 高田 和外, 岡地 祥太郎, 二宮 記代子, 森岡 悠, 田中 健太郎, 榎本 泰典

アレルギー   Vol. 60 ( 3 )   2011

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Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本アレルギー学会  

DOI： 10.15036/arerugi.60.487_3