2021/11/05 更新

写真a

イトウ リンタロウ
伊藤 倫太郎
ITO Rintaro
所属
大学院医学系研究科 革新的生体可視化技術開発産学協同研究講座 特任助教
職名
特任助教

学位 1

  1. 博士(医学) ( 2017年3月   名古屋大学 ) 

研究キーワード 5

  1. 人工知能

  2. コンピューター支援診断

  3. 画像診断

  4. 放射線医学

  5. 人工知能

研究分野 2

  1. ライフサイエンス / 放射線科学

  2. ライフサイエンス / 放射線科学

経歴 2

  1. 名古屋大学医学部附属病院   放射線部   病院助教

    2017年10月 - 現在

  2. 名古屋大学   医員

    2013年4月 - 2017年9月

学歴 2

  1. 名古屋大学   医学系研究科   総合医学専攻

    - 2017年3月

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    国名: 日本国

  2. 名古屋大学   医学部   医学科

    - 2011年3月

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    国名: 日本国

所属学協会 3

  1. 日本医学放射線学会

  2. 日本肺癌学会

  3. 日本メディカルAI学会

 

論文 30

  1. Radiomics in breast MRI: current progress toward clinical application in the era of artificial intelligence.

    Satake H, Ishigaki S, Ito R, Naganawa S

    La Radiologia medica     2021年10月

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    記述言語:英語  

    DOI: 10.1007/s11547-021-01423-y

    PubMed

  2. Peripheral Retinal Leakage after Intravenous Administration of a Gadolinium-based Contrast Agent: Age Dependence, Temporal and Inferior Predominance and Potential Implications for Eye Homeostasis.

    Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021年10月

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    記述言語:英語   出版者・発行元:日本磁気共鳴医学会  

    <p>Purpose: Peripheral retinal leakage (PRL) of contrast medium from the ora serrata (i.e., the peripheral part of the retina) was recently reported in normal eyes using ultra-widefield fluorescein angiography. We occasionally see PRL of gadolinium-based contrast agents (GBCAs) in the vitreous from the temporal and inferior sides of the ora serrata on MR images of subjects without ophthalmic disease. In this study, we retrospectively evaluated these MR images to determine if PRL was associated with aging. We also evaluated whether the initial leakage appeared in the temporal and inferior sides, and whether there was uniform distribution within the vitreous after 24 hours.</p><p>Methods: In 127 subjects (9 volunteers, 85 patients with sudden deafness, and 33 patients with a suspicion of endolymphatic hydrops), pre- and post-contrast-enhanced heavily T2-weighted 3D-fluid attenuated inversion recovery (FLAIR) images were obtained. The presence or absence of PRL was subjectively evaluated. For patients with a suspicion of endolymphatic hydrops, 3D-real inversion recovery (IR) images were also obtained at pre-, 10 mins, 4 hours, and 24 hours after intravenous administration (IV) of GBCA. Four circular ROIs were placed in the vitreous humor and the signal intensity was measured.</p><p>Results: In the cases with PRL (n = 88) and without PRL (n = 47), the median age was 59 and 47 years, respectively (<i>P</i> = 0.001). At 4 hours after IV-GBCA, the mean signal increase in the inferior temporal ROI was greater than all the other ROIs. At 24 hours after IV-GBCA, no significant difference in signal intensity was observed for the four ROIs.</p><p>Conclusion: PRL of GBCA is age-dependent and occurs mainly from the inferior temporal side of the ora serrata. The contrast effect was uniformly distributed at 24 hours after IV-GBCA. Future observations in a variety of diseases will determine the clinical significance of these findings.</p>

    DOI: 10.2463/mrms.mp.2021-0100

    PubMed

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  3. Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients

    Kamiya Saki, Satake Hiroko, Hayashi Yoko, Ishigaki Satoko, Ito Rintaro, Kawamura Mariko, Taoka Toshiaki, Iwano Shingo, Naganawa Shinji

    BREAST CANCER     2021年9月

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  4. Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study

    Taoka Toshiaki, Ito Rintaro, Nakamichi Rei, Kamagata Koji, Sakai Mayuko, Kawai Hisashi, Nakane Toshiki, Abe Takashi, Ichikawa Kazushige, Kikuta Junko, Aoki Shigeki, Naganawa Shinji

    JAPANESE JOURNAL OF RADIOLOGY     2021年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Journal of Radiology  

    Purpose: The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate the brain’s glymphatic function or interstitial fluid dynamics. This study aimed to evaluate the reproducibility of the DTI-ALPS method and the effect of modifications in the imaging method and data evaluation. Materials and methods: Seven healthy volunteers were enrolled in this study. Image acquisition was performed for this test–retest study using a fixed imaging sequence and modified imaging methods which included the placement of region of interest (ROI), imaging plane, head position, averaging, number of motion-proving gradients, echo time (TE), and a different scanner. The ALPS-index values were evaluated for the change of conditions listed above. Results: This test–retest study by a fixed imaging sequence showed very high reproducibility (intraclass coefficient = 0.828) for the ALPS-index value. The bilateral ROI placement showed higher reproducibility. The number of averaging and the difference of the scanner did not influence the ALPS-index values. However, modification of the imaging plane and head position impaired reproducibility, and the number of motion-proving gradients affected the ALPS-index value. The ALPS-index values from 12-axis DTI and 3-axis diffusion-weighted image (DWI) showed good correlation (r = 0.86). Also, a shorter TE resulted in a larger value of the ALPS-index. Conclusion: ALPS index was robust under the fixed imaging method even when different scanners were used. ALPS index was influenced by the imaging plane, the number of motion-proving gradient axes, and TE in the imaging sequence. These factors should be uniformed in the planning ALPS method studies. The possibility to develop a 3-axis DWI-ALPS method using three axes of the motion-proving gradient was also suggested.

    DOI: 10.1007/s11604-021-01187-5

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  5. Age estimates from brain magnetic resonance images of children younger than two years of age using deep learning 国際誌

    Kawaguchi Masahiro, Kidokoro Hiroyuki, Ito Rintaro, Shiraki Anna, Suzuki Takeshi, Maki Yuki, Tanaka Masaharu, Sakaguchi Yoko, Yamamoto Hiroyuki, Takahashi Yosiyuki, Naganawa Shinji, Natsume Jun

    MAGNETIC RESONANCE IMAGING   79 巻   頁: 38 - 44   2021年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Magnetic Resonance Imaging  

    © 2021 Elsevier Inc. The accuracy of brain age estimates from magnetic resonance (MR) images has improved with the advent of deep learning artificial intelligence (AI) models. However, most previous studies on predicting age emphasized aging from childhood to adulthood and old age, and few studies have focused on early brain development in children younger than 2 years of age. Here, we performed brain age estimates based on MR images in children younger than 2 years of age using deep learning. Our AI model, developed with one slice each of raw T1- and T2-weighted images from each subject, estimated brain age with a mean absolute error of 8.2 weeks (1.9 months). The estimates of our AI model were close to those of human specialists. The AI model also estimated the brain age of subjects with a myelination delay as significantly younger than the chronological age. These results indicate that the prediction accuracy of our AI model approached that of human specialists and that our simple method requiring less data and preprocessing facilitates a radiological assessment of brain development, such as monitoring maturational changes in myelination.

    DOI: 10.1016/j.mri.2021.03.004

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  6. Cross-sectional Area of the Superior Petrosal Sinus is Reduced in Patients with Significant Endolymphatic Hydrops.

    Naganawa S, Ito R, Kawai H, Kawamura M, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021年4月

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    記述言語:英語   出版者・発行元:日本磁気共鳴医学会  

    <p>Purpose: To evaluate the relationship between the size of the venous structures related to the inner ear and the degree of endolymphatic hydrops (EH).</p><p>Methods: Thirty-four patients with a suspicion of EH underwent whole brain MR imaging including the inner ear. Images were obtained pre- and post-administration, and at 4 and 24 hours after the intravenous administration of a gadolinium-based contrast agent (IV-GBCA). The cross-sectional areas (CSA) of the internal jugular vein (IJV), superior petrosal sinus (SPS), and inferior petrosal sinus (IPS) were measured on the magnetization prepared rapid acquisition of gradient echo (MPRAGE) images obtained immediately after the IV-GBCA. The grade of EH was determined on the hybrid of reversed image of positive endolymph signal and native image of positive perilymph signal (HYDROPS) images obtained at 4 hours after IV-GBCA as no, mild, and significant EH according to the previously proposed grading system for the cochlea and vestibule, respectively. The ipsilateral CSA was compared between groups with each level of EH grade. <i>P</i> < 0.05 was considered statistically significant.</p><p>Results: There were no statistically significant differences between EH grades for the CSA of the IJV or that of the IPS in either the cochlea or the vestibule. The CSA of the SPS in the groups with significant EH was significantly smaller than that in the group with no EH, for both the cochlea (<i>P</i> < 0.01) and the vestibule (<i>P</i> < 0.05). In an ROC analysis to predict significant EH, the cut-off CSA value in the SPS was 3.905 mm<sup>2</sup> for the cochlea (AUC: 0.8762, 95% confidence interval [CI]: 0.7952‒0.9572) and 3.805 mm<sup>2</sup> for the vestibule (AUC: 0.7727, 95% CI: 0.6539‒0.8916).</p><p>Conclusion: In the ears with significant EH in the cochlea or vestibule, the CSA of the ipsilateral SPS was smaller than in the ears without EH.</p>

    DOI: 10.2463/mrms.mp.2021-0010

    PubMed

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  7. MR Imaging of Endolymphatic Hydrops in Five Minutes.

    Naganawa S, Ito R, Kawai H, Kawamura M, Taoka T, Sakai M, Ichikawa K, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021年4月

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    記述言語:英語   出版者・発行元:日本磁気共鳴医学会  

    <p>In this study, we present images acquired by a fast-imaging method for the evaluation of endolymphatic hydrops after intravenous administration of a single dose of gadolinium-based contrast agent. We utilized the hybrid of reversed image of MR cisternography and a positive perilymph signal by heavily T2- weighted 3D-fluid attenuated inversion recovery-multiplied by T2 (HYDROPS2-Mi2) method combined with deep learning reconstruction denoising. The scan time for the fast protocol was approximately 5 mins, which is far shorter than previously reported scan times. The fast acquisition provides similar image quality and less motion artifacts compared to the longer method.</p>

    DOI: 10.2463/mrms.ici.2021-0022

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  8. Diffusion analysis of fluid dynamics with incremental strength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics

    Taoka Toshiaki, Kawai Hisashi, Nakane Toshiki, Abe Takashi, Nakamichi Rei, Ito Rintaro, Sato Yuki, Sakai Mayuko, Naganawa Shinji

    JAPANESE JOURNAL OF RADIOLOGY   39 巻 ( 4 ) 頁: 315 - 323   2021年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Japanese Journal of Radiology  

    © 2021, The Author(s). Purpose: To visualize and analyze the dynamics of cerebrospinal fluid (CSF) motion in the cranium, we evaluated the distribution of motion-related signal dephasing by CSF on Diffusion ANalysis of fluid DYnamics with Incremental Strength of Motion proving gradient (DANDYISM) method, a composite imaging method using various low b values. Materials and methods: This study examined ten subjects aged 25–58. We acquired DWIs on a 3T clinical scanner with b values 0, 50, 100, 200, 300, 500, 700, and 1000 s/mm2 in total imaging time of 4 min. We constructed DANDYISM images and evaluated the CSF area distribution with decreased motion-dephasing signal using a scoring method. Results: The DANDYISM images showed statistically significant higher CSF scores in the ventral posterior fossa, suprasellar cistern, and Sylvian vallecula compared to the lateral ventricle and frontal and parietal CSF spaces, indicating greater CSF movement in the former areas. Conclusion: The results indicated prominent CSF motions in the ventral portion of the posterior fossa, suprasellar cistern, and Sylvian fissure but smaller motions in the lateral ventricles and parietal subarachnoid space. This method may provide information of CSF dynamics in the clinical settings within short imaging time.

    DOI: 10.1007/s11604-020-01075-4

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    その他リンク: http://link.springer.com/article/10.1007/s11604-020-01075-4/fulltext.html

  9. Relationship between Time-dependent Signal Changes in Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space.

    Naganawa S, Ito R, Nakamichi R, Kawamura M, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    <p>Purpose: To investigate the association between signal changes over time in perivenous cystic structures near the superior sagittal sinus and leakage of a gadolinium-based contrast agent (GBCA) into the subarachnoid space in patients with suspected endolymphatic hydrops.</p><p>Methods: Fifty-one cystic structures in 27 cases were evaluated. The signal intensity of the cystic structures was measured on 3D real inversion recovery (3D-real IR) images obtained at pre-, and at 10 min, 4 hrs and 24 hrs post-intravenous administration (IV) of GBCA. Signal enhancement of the cystic structures from the pre-contrast images at each time point was compared in subjects with leakage (positive) versus those without leakage (negative) using an ANOVA. Fisher's exact probability test was used to compare the maximum contrast-enhanced time point between positive and negative groups. We used 5% as a threshold to determine statistical significance.</p><p>Results: In leakage positive subjects, mean signal enhancement of the cysts was significantly greater at 4 and 24 hrs compared to 10 min. However, although there was a trend of an increase from 4 to 24 hrs, the difference was not significant. In the leakage negative group, mean signal enhancement of the cysts was significantly higher at 4 hrs compared to 10 min and 24 hrs. There was no significant difference between 10 min and 24 hrs. In the positive group, the maximum signal increase was found in 10/38 and 28/38 cysts at 4 and 24 hrs after IV-GBCA, respectively. In the leakage negative group, the maximum signal increase was found in 10/13 and 3/13 cysts at 4 and 24 hrs, respectively (<i>P</i> = 0.0019).</p><p>Conclusion: There was an association between signal changes over time after IV-GBCA in perivenous cystic structures and leakage of GBCA. Further research to clarify the impact of cystic structures on the function of the waste clearance system of the brain is warranted.</p>

    DOI: 10.2463/mrms.mp.2020-0138

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  10. Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging.

    Taoka T, Kawai H, Nakane T, Abe T, Nakamichi R, Ito R, Sasaki Y, Nishida A, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    <p>Purpose: Decrease in signal of the cerebrospinal fluid (CSF) on low b-value diffusion weighted image (DWI) due to non-uniform flow can provide additional information regarding CSF motion. The purpose of the current study was to evaluate whether arterial pulsations constitute the driving force of CSF motion.</p><p>Methods: We evaluated the CSF signals within the Sylvian fissure on low b-value DWI in 19 patients with unilateral middle cerebral artery (MCA) occlusion. DWI with b-value of 500 s/mm<sup>2</sup> was evaluated for a decrease in CSF signal within the Sylvian fissure including the Sylvian vallecula and lower, middle, and higher Sylvian fissures and graded as follows: the same as contralateral side; smaller signal decrease than that on contralateral side; and no signal decrease. MR angiography (MRA) findings of MCA were graded as follows: the same as contralateral, lower signal than contralateral signal, and no signal. In 15 patients, regional cerebral blood flow (rCBF) was evaluated using single-photon emission computed tomography (SPECT) studies and graded as >90%, 90%–70%, and <70% rCBF compared to contralateral. The correlations between the gradings were evaluated using G likelihood-ratio test.</p><p>Results: There was no statistically significant correlation between the MRA and low b-value DWI gradings of CSF in all areas. There were statistically significant correlations between the decreases in CBF on SPECT and CSF signals in the middle Sylvian fissure.</p><p>Conclusion: The driving force of CSF pulsation in the Sylvian sinus may be related to the pulsations of the cerebral hemisphere rather than direct arterial pulsations.</p>

    DOI: 10.2463/mrms.mp.2020-0121

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  11. Iodine-related attenuation in contrast-enhanced dual-energy computed tomography in small-sized solid-type lung cancers is associated with the postoperative prognosis 国際誌

    Iwano Shingo, Kamiya Shinichiro, Ito Rintaro, Nakamura Shota, Naganawa Shinji

    CANCER IMAGING   21 巻 ( 1 ) 頁: 7 - 7   2021年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Imaging  

    Background: To investigate the correlation between iodine-related attenuation in contrast-enhanced dual-energy computed tomography (DE-CT) and the postoperative prognosis of surgically resected solid-type small-sized lung cancers. Methods: We retrospectively reviewed the DE-CT findings and postoperative course of solid-type lung cancers ≤3 cm in diameter. After injection of iodinated contrast media, arterial phases were scanned using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation (3D-IRA) of primary tumors at the arterial phase was computed using the “lung nodule” application software. The corrected 3D-IRA normalized to the patient’s body weight and contrast medium concentration was then calculated. Results: A total of 120 resected solid-type lung cancers ≤3 cm in diameter were selected for analysis (82 males and 38 females; mean age, 67 years). During the observation period (median, 47 months), 32 patients showed postoperative recurrence. Recurrent tumors had significantly lower 3D-IRA and corrected 3D-IRA at early phase compared to non-recurrent tumors (p = 0.046 and p = 0.027, respectively). The area under the receiver operating characteristic curve for postoperative recurrence was 0.624 for the corrected 3D-IRA at early phase (p = 0.025), and the cutoff value was 5.88. Kaplan–Meier curves for disease-free survival indicated that patients showing tumors with 3D-IRA > 5.88 had a significantly better prognosis than those with tumors showing 3D-IRA < 5.88 (p = 0.017). Conclusions: The 3D-IRA of small-sized solid-type lung cancers on contrast-enhanced DE-CT was significantly associated with postoperative prognosis, and low 3D-IRA tumors showed a higher TNM stage and a significantly poorer prognosis.

    DOI: 10.1186/s40644-020-00368-1

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  12. Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting 査読有り

    Naganawa Shinji, Ito Rintaro, Kato Yutaka, Kawai Hisashi, Taoka Toshiaki, Yoshida Tadao, Maruyama Katsuya, Murata Katsutoshi, Koerzdoerfer Gregor, Pfeuffer Josef, Nittka Mathias, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   20 巻 ( 1 ) 頁: 91 - 98   2021年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Magnetic Resonance in Medical Sciences  

    © 2020 Japanese Society for Magnetic Resonance in Medicine. Purpose: To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF). Methods: Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. The signal intensity on the 3D-real IR image of the cerebrospinal fluid (CSF) in the cerebellopontine angle cistern (CPA), Sylvian fissure (Syl), lateral ventricle (LV), and cochlear perilymph (CPL) was measured. The T1 and T2 values of cerebellar gray (GM) and white matter (WM) were measured using MRF. Each averaged value at the various time points was compared using an analysis of variance. Results: The signal intensity on the 3D-real IR image in each CSF region peaked at 4 h, and was decreased significantly by 24 h (P < 0.05). All patients had a maximum signal intensity at 4 h in the CPA, and Syl. The mean CPL signal intensity peaked at 4 h and decreased significantly by 24 h (P < 0.05). All patients but two had a maximum signal intensity at 4 h. Regarding the T1 value in the cerebellar WM and GM, the T1 value at 10 min post-IV-GBCA was significantly decreased compared to the pre-contrast scan, but no significant difference was observed at the other time points. There was no significant change in T2 in the gray or white matter at any of the time points. Conclusion: Time course of GBCA after IV-SD-GBCA could be evaluated by 3D-real IR imaging in CSF spaces and in the brain by MRF.

    DOI: 10.2463/mrms.mp.2020-0030

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  13. Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration 査読有り

    Naganawa Shinji, Ito Rintaro, Nakamichi Rei, Kawamura Mariko, Kawai Hisashi, Taoka Toshiaki, Yoshida Tadao, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   20 巻 ( 3 ) 頁: 245 - 252   2021年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Magnetic Resonance in Medical Sciences  

    Purpose: The purpose of this retrospective study was to investigate the relationship between the number and size of cystic structures around the cortical veins near the superior sagittal sinus and the leakage of gadolinium-based contrast agent (GBCA) around the cortical veins. Methods: Of 190 patients (91 male and 99 female), that were scanned at 4 h after an intravenous injection of GBCA as a diagnostic examination for endolymphatic hydrops, 6 patients with GBCA leakage were younger than the previously proposed threshold age of 37.3 years for leakage. Six age-matched patients without leakage were also included for reference. In addition, we included 8 cases without leakage that were older than the hypothesized threshold of 37.3 years, as well as 8 age-matched patients with GBCA leakage into the cerebrospinal fluid space. The number of cysts was counted and the sizes were measured in these 28 patients (age: 32–60 years old, 13 men and 15 women). Results: The mean number of cysts surrounding the cortical veins in the parasagittal region was 4.29 ± 1.77 vs. 1.79 ± 1.05 (P = 0.0001) in the subjects with and without GBCA leakage, respectively. The mean size of the largest cysts was at 8.89 ± 3.49 mm vs. 5.69 ± 2.29 (P = 0.009) in the subjects with and without GBCA leakage, respectively. Conclusion: The number and size of the perivenous cystic structures near the superior sagittal sinus is greater in subjects with GBCA leakage into the subarachnoid space compared with those without leakage. Future research regarding the histological and functional details of these parasagittal cystic structures is needed.

    DOI: 10.2463/mrms.mp.2020-0062

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  14. COVID-19 肺炎におけるAI研究の動向および問題点について

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    医用画像情報学会雑誌   38 巻 ( 2 ) 頁: 32 - 40   2021年

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    記述言語:日本語   出版者・発行元:医用画像情報学会  

    <p>There have been many studies on the use of AI for the diagnosis of COVID-19 pneumonia. Although these AIs have high performance, there are several points that need to be considered when using them in clinical practice. In this paper, we comprehensively reviewed the AI studies for COVID-19 pneumonia that were registered in PubMed until December 2020. The performance and problems of these AIs were presented.</p>

    DOI: 10.11318/mii.38.32

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  15. Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer 査読有り

    Iwano Shingo, Ito Shinji, Kamiya Shinichiro, Ito Rintaro, Kato Katsuhiko, Naganawa Shinji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 2 ) 頁: 205 - 215   2020年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    © 2020 Nagoya University. We retrospectively evaluated the frequency of unexpected accumulation of radioactive iodine on the post-therapy whole-body scan (Rx-WBS) after radioactive iodine (RAI) ablation therapy in patients with differentiated thyroid cancer (DTC). We searched our institutional database for Rx-WBSs of DTC patients who underwent RAI ablation or adjuvant therapy between 2012 and 2019. Patients with distant metastasis diagnosed by CT or PET/CT before therapy, and those had previously received RAI therapy were excluded. In total, 293 patients (201 female and 92 male, median age 54 years) were selected. Two nuclear medicine physicians interpreted the Rx-WBS images by determining the visual intensity of radioiodine uptake by the thyroid bed, cervical and mediastinal lymph nodes, lungs, and bone. Clinical features of the patients with and without the metastatic accumulation were compared by chi-square test and median test. Logistic regression analyses were performed to compare the association between the presence of metastatic accumulation and these clinical factors. Eighty-four of 293 patients (28.7%) showed metastatic accumulation. Patients with metastatic RAI accumulation showed a significantly higher frequency of pathological N1 (pN1) and serum thyroglobulin (Tg) > 1.5 ng/ml under TSH stimulation (p = 0.035 and p = 0.031, respectively). Logistic regression analysis indicated that a serum Tg > 1.5 ng/ml was significantly correlated with the presence of metastatic accumulation (odds ratio = 1.985; p = 0.033). In conclusion, Patients with Tg > 1.5 ng/ml were more likely to show metastatic accumulation. In addition, the presence of lymph node metastasis at the initial thyroid surgery was also associated with this unexpected metastatic accumulation.

    DOI: 10.18999/nagjms.82.2.205

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  16. White matter microstructural changes in tuberous sclerosis: Evaluation by neurite orientation dispersion and density imaging (NODDI) and diffusion tensor images 査読有り 国際誌

    Taoka Toshiaki, Aida Noriko, Fujii Yuta, Ichikawa Kazushi, Kawai Hisashi, Nakane Toshiki, Ito Rintaro, Naganawa Shinji

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 436 - 436   2020年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    © 2020, The Author(s). Neurite orientation dispersion and density imaging (NODDI) is a novel diffusion method for evaluating tissue microstructure, and may provide additional information over conventional diffusion tensor imaging (DTI). We evaluated NODDI and DTI parameters in cases of tuberous sclerosis (TS) to assess microstructural changes in the white matter. Eleven cases of tuberous sclerosis and eight age-matched controls underwent NODDI and DTI. We performed qualitative analysis and tract-based spatial statistics (TBSS) analysis of the NODDI parameters (Ficv: intracellular volume fraction, Fiso: isotropic fraction, ODI: orientation dispersion index) as well as DTI parameters (MD: mean diffusivity, FA: fractional anisotropy). We also performed a correlation analysis between clinical symptoms and parameters. The qualitative analysis indicated that the Ficv had a lower value in TS cases particularly in the tubers adjacent to the white matter. The TBSS analysis showed that the TS cases had decreased Ficv in a greater area compared to the other parameters including MD. In particular, the Ficv was decreased in deep white matter, such as the superior longitudinal fascicles (SLF). The application of NODDI to TS cases revealed tissue microstructural changes, and particularly the Ficv could detect more widespread abnormalities in white matter structure compared to DTI parameters.

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  17. The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics 査読有り

    Naganawa Shinji, Ito Rintaro, Taoka Toshiaki, Yoshida Tadao, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   19 巻 ( 1 ) 頁: 1 - 4   2020年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Magnetic Resonance in Medical Sciences  

    © 2019 Japanese Society for Magnetic Resonance in Medicine. We currently obtain pre-and post-contrast enhanced whole brain 3D-real inversion recovery images for the evaluation of endolymphatic hydrops. We noticed that the space between the pial sheath surrounding the cortical veins and the cortical venous wall is enhanced and this enhancement seems to connect to the meningeal lymphatics along superior sagittal sinus. This new anatomical concept regarding the outflow from the glymphatic system might be important for the future research in neuroscience.

    DOI: 10.2463/mrms.bc.2019-0099

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  18. Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes 査読有り 国際誌

    Hayashi Yoko, Satake Hiroko, Ishigaki Satoko, Ito Rintaro, Kawamura Mariko, Kawai Hisashi, Iwano Shingo, Naganawa Shinji

    BRITISH JOURNAL OF RADIOLOGY   93 巻 ( 1106 ) 頁: 20190712 - 20190712   2020年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:British Journal of Radiology  

    Objective: To evaluate the associations between computer-aided diagnosis (CAD)-generated kinetic volume parameters and survival in triple-negative breast cancer (TNBC) patients. Methods: 40 patients with TNBC who underwent pre-operative MRI between March 2008 and March 2014 were included. We analyzed CAD-generated parameters on dynamic contrast-enhanced MRI, visual MRI assessment, and histopathological data. Cox proportional hazards models were used to determine associations with survival outcomes. Results: 12 of the 40 (30.0%) patients experienced recurrence and 7 died of breast cancer after a median follow-up of 73.6 months. In multivariate analysis, higher percentage volume (%V) with more than 200% initial enhancement rate correlated with worse disease-specific survival (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22; p-value, 0.014) and higher %V with more than 100% initial enhancement rate followed by persistent curve type at 30% threshold correlated with worse disease-specific survival (hazard ratio, 1.33; 95% confidence interval, 1.10-1.61; p-value, 0.004) and disease-free survival (hazard ratio, 1.27; 95% confidence interval, 1.12-1.43; p-value, 0.000). Conclusion: CAD-generated kinetic volume parameters may correlate with survival in TNBC patients. Further study would be necessary to validate our results on larger cohorts. Advances in knowledge: CAD generated kinetic volume parameters on breast MRI can predict recurrence and survival outcome of patients in TNBC. Varying the enhancement threshold improved the predictive performance of CAD generated kinetic volume parameter.

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  19. Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent 査読有り

    Naganawa Shinji, Ito Rintaro, Kawai Hisashi, Taoka Toshiaki, Yoshida Tadao, Sone Michihiko

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   19 巻 ( 4 ) 頁: 375 - 381   2020年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Magnetic Resonance in Medical Sciences  

    © 2020 Japanese Society for Magnetic Resonance in Medicine. Purpose: It has been reported previously that intravenously administered gadolinium-based contrast agent (GBCA) leaks into the subarachnoid space around the cortical veins at 4 h after injection in all old people over 37 years, but not in younger people up to 37 years of age in 3D-real IR images. The purpose of this study was to investigate whether there was a strict threshold of 37 years of age for the leakage of the GBCA into the subarachnoid space. Methods: The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. The patient’s age ranged from 14 to 81 years. Two experienced neuroradiologists evaluated the images to determine whether the GBCA leakage around the cortical veins was positive or negative. Any discrepancies between the two observers were discussed and a consensus was obtained. A Mann–Whitney U test and receiver operating characteristic (ROC) curve analysis were used to compare the positive and the negative group and to set the age cut-off value for the prediction of GBCA leakage. Results: The GBCA leakage around the cortical veins was negative in 35 patients and positive in 155 patients. The average age was 33 ± 11 years in the negative group, and 55 ± 12 years in the positive group (P < 0.01). In the ROC analysis for the age and leakage of the GBCA, an area under the curve was 0.905 and the cut-off age was 37.317 years (sensitivity of 0.942 and specificity of 0.771). Conclusion: Intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age.

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  20. A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019 査読有り 国際誌

    Ito Rintaro, Iwano Shingo, Naganawa Shinji

    DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY   26 巻 ( 5 ) 頁: 443 - 448   2020年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Diagnostic and Interventional Radiology  

    © Turkish Society of Radiology 2020. The results of research on the use of artificial intelligence (AI) for medical imaging of the lungs of patients with coronavirus disease 2019 (COVID-19) has been published in various forms. In this study, we reviewed the AI for diagnostic imaging of COVID-19 pneumonia. PubMed, arX-iv, medRxiv, and Google scholar were used to search for AI studies. There were 15 studies of COVID-19 that used AI for medical imaging. Of these, 11 studies used AI for computed tomography (CT) and 4 used AI for chest radiography. Eight studies presented independent test data, 5 used disclosed data, and 4 disclosed the AI source codes. The number of datasets ranged from 106 to 5941, with sensitivities ranging from 0.67–1.00 and specificities ranging from 0.81–1.00 for prediction of COVID-19 pneumonia. Four studies with independent test datasets showed a breakdown of the data ratio and reported prediction of COVID-19 pneumonia with sensitivity, specificity, and area under the curve (AUC). These 4 studies showed very high sensitivity, specificity, and AUC, in the range of 0.9–0.98, 0.91–0.96, and 0.96–0.99, respectively.

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  21. Multimodal Imaging in Bilateral Nature of the Choroidal Osteoma After Intraocular Inflammation Caused by Harada Disease 査読有り 国際誌

    Ozawa Kenji, Iwase Takeshi, Ito Yasuki, Onda Masahiro, Shiraki Ikumi, Kumada Mitsuki, Ito Rintaro, Mochizuki Kiyofumi

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   39 巻 ( 9 ) 頁: E40 - E41   2019年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Retina  

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  22. Utility of Metabolic Parameters on FDG PET/CT in the Classification of Early-Stage Lung Adenocarcinoma Prediction of Pathological Invasive Size 査読有り 国際誌

    Iwano Shingo, Ito Shinji, Kamiya Shinichiro, Ito Rintaro, Kato Katsuhiko, Naganawa Shinji

    CLINICAL NUCLEAR MEDICINE   44 巻 ( 7 ) 頁: 560 - 565   2019年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Nuclear Medicine  

    © 2019 Wolters Kluwer Health, Inc. All rights reserved. Purpose This paper aims to explore the role of a metabolic parameter on 18F-FDG-PET/CT for clinical T-classification in early-stage adenocarcinoma. Patients and Methods One hundred six surgically resected pathological TNM stage (p-stage) 0/I lung adenocarcinomas were retrospectively reviewed. The solid size (SS) measured on thin-section CT and the pathological invasive size (IS) of tumors were recorded. The SUVmax and metabolic tumor volume with SUV ≥1.0 (MTV1.0) derived from PET/CT data were measured on a workstation, and the metabolic tumor diameter with SUV ≥1.0 (MTD1.0) was calculated automatically from MTV1.0. For the correlations between the IS and the SS, MTD1.0, or SUVmax, Pearson's correlation coefficients were compared using the Meng-Rosenthal-Rubin method. Additionally, the reproducibility between the clinical TNM stage (c-stage), based on the SS or MTD1.0, and the p-stage was analyzed using the kappa coefficient (k). Results For the correlations between the IS and the other parameters, Pearson correlation coefficient was 0.630 for the SS, 0.600 for the SUVmax, and 0.725 for MTD1.0. MTD1.0 correlated significantly and more strongly with the IS than the SS and the SUVmax did (P = 0.040, and P = 0.008, respectively). The reproducibility between p-stage and c-stage based on the SS was moderate (k = 0.529, P < 0.001), whereas that between p-stage and c-stage based on MTD1.0 was substantial (k = 0.676, P < 0.001). Conclusions MTD1.0 on FDG-PET/CT was correlated significantly and more strongly with the pathological IS in lung adenocarcinomas than with the SS on thin-section CT. FDG-PET/CT could classify more precisely early-stage lung adenocarcinoma than the presently used T-classification based on thin-section CT findings.

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  23. Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis 査読有り 国際誌

    Kamiya Shinichiro, Iwano Shingo, Umakoshi Hiroyasu, Ito Rintaro, Shimamoto Hironori, Nakamura Shota, Naganawa Shinji

    RADIOLOGY   287 巻 ( 3 ) 頁: 1030 - 1040   2018年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Radiology  

    © RSNA, 2018 Purpose: To investigate the relationship between the postoperative prognosis of patients with part-solid non–small cell lung cancer and the solid component size acquired by using three-dimensional (3D) volumetry software on multidetector computed tomographic (CT) images. Materials and A retrospective study by using preoperative multidetector Methods: CT data with 0.5-mm section thickness, clinical records, and pathologic reports of 96 patients with primary subsolid non–small cell lung cancer (47 men and 49 women; mean age 6 standard deviation, 66 years 6 8) were reviewed. Two radiologists measured the two-dimensional (2D) maximal solid size of each nodule on an axial image (hereafter, 2D MSSA), the 3D maximal solid size on multiplanar reconstructed images (hereafter, 3D MSSMPR), and the 3D solid volume of greater than 0 HU (hereafter, 3D SV0HU) within each nodule. The correlations between the postoperative recurrence and the effects of clinical and pathologic characteristics, 2D MSSA, 3D MSSMPR, and 3D SV0HU as prognostic imaging biomarkers were assessed by using a Cox proportional hazards model. Results: For the prediction of postoperative recurrence, the area under the receiver operating characteristics curve was 0.796 (95% confidence interval: 0.692, 0.900) for 2D MSSA, 0.776 (95% confidence interval: 0.667, 0.886) for 3D MSSMPR, and 0.835 (95% confidence interval: 0.749, 0.922) for 3D SV0HU. The optimal cutoff value for 3D SV0HU for predicting tumor recurrence was 0.54 cm3, with a sensitivity of 0.933 (95% confidence interval: 0.679, 0.998) and a specificity of 0.716 (95% confidence interval: 0.605, 0.811) for the recurrence. Significant predictive factors for disease-free survival were 3D SV0HU greater than or equal to 0.54 cm3 (hazard ratio, 6.61; P = .001) and lymphatic and/or vascular invasion derived from histopathologic analysis (hazard ratio, 2.96; P = .040). Conclusion: The measurement of 3D SV0HU predicted the postoperative prognosis of patients with part-solid lung cancer more accurately than did 2D MSSA and 3D MSSMPR.

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  24. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis 査読有り 国際誌

    Umakoshi Hiroyasu, Iwano Shingo, Yokoi Kohei, Ito Shinji, Ito Rintaro, Kawaguchi Koji, Fukui Takayuki, Naganawa Shinji

    CLINICAL LUNG CANCER   19 巻 ( 1 ) 頁: E37 - E45   2018年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Lung Cancer  

    © 2017 The Authors We reviewed the concordance between the clinical stage and pathologic stage for primary lung cancer. We evaluated 289 surgically resected lung cancers ≤ 3 cm. Multivariate survival analysis showed that the significant predictive factors for postoperative disease-free survival were pathologic stage and the maximum standardized uptake value (SUVmax) of primary lesions. Combining SUVmax with clinical stage might improve the prediction of therapeutic outcomes. Introduction: We aimed to determine the concordance between the clinical stage (c-stage) and pathologic stage (p-stage) for patients with small-size lung cancer. Additionally we searched for prognostic factors other than the TNM stage. Patients and Methods: We retrospectively reviewed the preoperative multidetector computed tomography (CT) and positron emission tomography/CT reports, surgical records, and pathologic reports of patients with primary lung cancer ≤ 3 cm. The Union for International Cancer Control TNM seventh edition classification of c-stage and p-stage were compared. The tumors were classified into multiple subgroups by concordance or discordance between the c-stage and p-stage. Disease-free survival (DFS) was assessed using survival analysis to assess the tumor characteristics that were predictive of prognosis. Results: A total of 289 surgically resected primary lung cancers were evaluated. The concordance between c-stage and p-stage was 65.4%, with moderate reproducibility (kappa coefficient, 0.467). The upstaging rate from c-stage I to p-stage II-IV was 9.4%, and these patients had significantly worse DFS than those with a concordant stage I classification (P <.001). The main reason for upstaging was an underestimation of metastases to the hilar lymph nodes (n = 7) or mediastinal lymph nodes (n = 11). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were p-stage (hazard ratio, 1.342; P =.003) and maximum standardized uptake value on positron emission tomography/CT (hazard ratio, 12.162; P =.001). Conclusion: The concordance rate between c-stage and p-stage for small primary lung cancers had moderate reproducibility. Discordance between c-stage I and p-stage II-IV significantly affected DFS. The maximum standardized uptake value of the primary lesion was an independent prognostic factor, and combining it with c-stage might improve the prediction of therapeutic outcomes.

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  25. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer 査読有り 国際誌

    Ito Rintaro, Iwano Shingo, Shimamoto Hironori, Umakoshi Hiroyasu, Kawaguchi Koji, Ito Shinji, Kato Katsuhiko, Naganawa Shinji

    EUROPEAN JOURNAL OF RADIOLOGY   95 巻   頁: 186 - 191   2017年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:European Journal of Radiology  

    Purpose To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs). Materials and methods We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44–85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness. DE-CT scanning in the arterial and delayed phases was performed after injection of iodinated contrast media using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation of primary tumors in the arterial and delayed phases was quantified automatically using “syngo Dual Energy Lung Nodules” application software, and the ratio of arterial phase to delayed phase enhancement (A/D ratio) was calculated. The A/D ratio and SUVmax on PET/CT were evaluated with respect to postoperative invasiveness by univariate logistic regression analysis. Results The A/D ratio was significantly correlated with lymphatic permeation, vascular invasion, and pleural involvement (p = 0.011, p = 0.021, and p = 0.010, respectively). In contrast, the SUVmax was significantly correlated with pleural involvement (p = 0.020) but not with lymphatic permeation or vascular invasion (p = 0.088 and p = 0.100, respectively). In the subgroup of patients with lesion diameters ≤2 cm, the A/D ratio was significantly correlated with locoregional invasiveness (p = 0.040), while the SUVmax was not (p = 0.121). Conclusion For the prediction of microscopic invasiveness of NSCLCs, the diagnostic performance of dual-phase DE-CT may be comparable to that of FDG-PET/CT.

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  26. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers 査読有り 国際誌

    Iwano Shingo, Ito Rintaro, Umakoshi Hiroyasu, Karino Takatoshi, Inoue Tsutomu, Li Yuanzhong, Naganawa Shinji

    PLOS ONE   12 巻 ( 1 ) 頁: e0170309   2017年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PLoS ONE  

    © 2017 Iwano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Purpose: We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. Materials and Methods: The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years' experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer. Results: Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were truepositive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were truepositive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD. Conclusion: Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

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  27. Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma? 査読有り

    Ito R, Iwano S, Kishimoto M, Ito S, Kato K, Naganawa S

    Annals of nuclear medicine   29 巻 ( 10 ) 頁: 897-905   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12149-015-1025-z

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  28. Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation. 査読有り

    Iwano S, Ito R, Umakoshi H, Ito S, Naganawa S

    The British journal of radiology   88 巻 ( 1055 ) 頁: 20150224   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1259/bjr.20150224

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  29. Prognostic evaluations of small size lung cancers by 18F-FDG PET/CT and thin-section CT. 査読有り

    Kishimoto M, Iwano S, Ito S, Kato K, Ito R, Naganawa S

    Lung cancer (Amsterdam, Netherlands)   86 巻 ( 2 ) 頁: 180-4   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lungcan.2014.09.006

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  30. Prediction of pathologic prognostic factors in patients with lung adenocarcinomas: comparison of thin-section computed tomography and positron emission tomography/computed tomography. 査読有り

    Iwano S, Kishimoto M, Ito S, Kato K, Ito R, Naganawa S

    Cancer imaging : the official publication of the International Cancer Imaging Society   14 巻   頁: 3   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/1470-7330-14-3

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▼全件表示

MISC 3

  1. PET/CTによる小型肺癌の術後予後予測 臨床病期と病理病期との比較

    岩野 信吾, 伊藤 倫太郎, 長縄 慎二, 川口 晃司, 福井 高幸, 横井 香平  

    肺癌57 巻 ( 5 ) 頁: 453 - 453   2017年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本肺癌学会  

  2. 脈絡膜悪性黒色腫の診断におけるIMP SPECT、FDG PET/CT、FDOPA PET/CTの比較

    加藤 克彦, 小田川 哲郎, 阿部 真治, 山口 博司, 伊藤 倫太郎, 伊藤 信嗣, 岩野 信吾, 長縄 慎二  

    核医学54 巻 ( Suppl. ) 頁: S194 - S194   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本核医学会  

  3. PET/CTは小型肺癌のTNM分類に基づく術後予後予測を補助する

    岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 伊藤 信嗣, 川口 晃司, 福井 高幸, 横井 香平, 加藤 克彦, 長縄 慎二  

    核医学54 巻 ( Suppl. ) 頁: S195 - S195   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本核医学会  

科研費 3

  1. 人工知能を用いた画像診断報告書の自然言語処理解析に関する検討

    研究課題/研究課題番号:21K15843  2021年4月 - 2024年3月

    科学研究費助成事業  若手研究

    伊藤 倫太郎

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    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    画像診断を行う放射線科読影医にとってCTやMRIなどの画像の読影を行い、診療を行う医者に必要な情報を提供することが主要な仕事の一つです。多種多様な画像、経時的な画像変化、臨床情報を含めた文書情報を把握した上で、報告書を作成する必要があります。日常的に大量の画像診断報告書を記載する必要があり、1件あたりに時間をかけて読影を行うことは難しいのが現状です。本研究では2018 年末にGoogle 社の発表したBERTを始めとする最先端の自然言語処理技術を画像診断に適応するものです。AIを使用した自然言語処理を用いて画像診断報告書の解析を行い、業務の補助となる最適な情報の提供について検討します。

  2. MRIによる脳内リンパ系の評価法の開発:睡眠との関連による評価

    研究課題/研究課題番号:21K07563  2021年4月 - 2024年3月

    科学研究費助成事業  基盤研究(C)

    田岡 俊昭, 宮田 聖子, 川井 恒, 岩本 邦弘, 野田 明子, 伊藤 倫太郎

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    担当区分:研究分担者 

    脳内リンパ系の活動性は、覚醒時と比較して睡眠時に大幅な効率の増大を示す事が示されている。本研究では、ヒトを対象として、睡眠に関連した脳内リンパ系の動態を、新たな手法を用いて非侵襲~無侵襲的に評価することを目的とする。研究に用いる主な手法はDiffusion Tensor Image analysis Along the Perivascular Space (DTI-ALPS)法である。この手法は、放線冠部分では、血管周囲腔の走行方向と投射繊維、連合線維の走行方向が互いに直交する事を利用して、拡散テンソル法で得られた3次元拡散データから、血管周囲腔の方向の拡散成分の比を算出する方法である。

  3. 超高精細形態画像と機能画像の統合解析による早期肺癌の次世代予後予測モデルの確立

    研究課題/研究課題番号:19K08149  2019年4月 - 2022年3月

    岩野 信吾

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    担当区分:研究分担者 

    原発性肺癌の臨床病期分類は胸部CTに様々な画像検査を組み合わせて決定され、最適な治療方針を決定する基盤情報である。しかし限られた空間分解能による形態診断の限界により病理病期分類との間に差を生じることがある。本研究では肺癌症例の膨大な画像・手術・病理データを活用し、浸潤性・予後に関連する超高精細CT、MRI、PETによる新たなバイオマーカー構築を探索し、これらを統合的に解析することで早期肺癌の予後予測の精度向上、次世代の肺癌病期分類改訂に貢献する。
    本研究では、本研究では肺癌症例の膨大な画像・手術・病理データを活用し、浸潤性・予後に関連する超高精細CT、MRI、PETによる新たなバイオマーカー構築を探索し、これらを統合的に解析することで早期肺癌の予後予測の精度向上、次世代の肺癌病期分類改訂に貢献することを目的としている。2020年11月より当施設に超高精細CTが導入され、肺癌症例の超高精細CTを収集中である。またPET/CT、従来型高精細CT、マイクロCTについて画像・臨床データベースから抽出し、それらがTNM分類や予後に与える影響についてレトロスペクティブな解析を行った。
    2019年度は本研究のベースとなる3本の原著論文が学術誌に掲載され、画像診断による新たなバイオマーカー構築という本研究の方向性が正しいことが明らかになった。
    1本目はマイクロCTを用いることにより肺腺癌の進展範囲を従来の高精細CTよりも正確に診断できるようになることを明らかにした。これは超高精細CTにより肺癌の進展範囲が従来型高精細CTよりも正確にできることを示している。
    2本目は高精細CTによって腫瘍内のすりガラス影を診断することで、すりガラス影そのものが腫瘍の予後に関係するこを明らかにしたものである。超高精細CTですりガラス影をさらに詳細に診断することで、高精細CTよりも正確な予後予測が可能になることを明らかにした。
    3本目はPET/CTにおけるSUV値に替わる新しい定量指標として(Metabolic Tumor Diameter)MTDを提唱し、それが早期肺癌の病理学的ステージ分類とよく一致していることを明らかにした。これは空間分解能の低いPET/CTであっても、3次元画像解析を行うことによりCTに匹敵するサイズ評価が可能であることを明らかにしたものである。
    2019年度中に本研究のベースとなる3本の学術論文が学術雑誌に掲載され、これを発展させた研究を遂行することができるようになった。
    2019年11月には名古屋大学医学部附属病院に超高精細CTが設置され、順調に稼働しており、肺癌症例の収集を開始している。
    2020年初頭からのCOVID-19の世界的流行に伴い、国内・海外学会が軒並み中止・延期となってしまったため、学会発表については十分には行えていないが、その時間を研究遂行と論文作成に充てることによって、当初の見込みどおりの進捗状況が得られている。
    本研究は3年の期間を設定し、原発性肺癌、特に早期肺癌の超高精細CT、UTE-MRI、PET画像・臨床データ収集・解析し、最終的に統合したデータを多変量解析し、新たな予後予測因子を探索する。研究代表者は、研究総括とともにCT・MRI画像解析を行い、分担者の中村彰太が肺癌症例のリクルートと臨床・病理解析を、伊藤信嗣はPET画像解析を、伊藤倫太郎はCADの開発とデータ解析を担当する。
    2020年度中は肺癌の超高精細CTの症例を収集し、ある程度症例が収集した時点で解析(マイクロCTや病理組織との対比)に取り組む予定である。同時に、dual-energy CTによる肺癌の悪性度評価に注目して、実際に患者の予後に影響しているかどうかを後ろ向きに解析する予定である。またるPET指標としてMTV (Metabolic Tumor Volume)の有用性が報告されている。これは定義された値以上のSUV値を示す領域の体積であり、腫瘍を球体と仮定して逆算した直径をMTD (Metabolic Tumor Diameter)と定義し、この新しい指標は病理学的浸潤径が病理組織と一致していると我々は2019年に報告した。当施設で2006年以降に手術治療が行われた肺癌症例について後向きにデータを収集し、PET画像を画像解析ワークステーションに転送してMTV・MTDの再計測を行い、予後との相関を検討する。