Updated on 2022/07/05

写真a

 
IMAEDA Miho
 
Organization
Nagoya University Hospital Clinical Oncology and Chemotherapy Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 博士(医学) ( 2017.3   名古屋大学 ) 

 

Papers 7

  1. Contribution of copy number variations to the risk of severe eating disorders

    Kushima Itaru, Imaeda Miho, Tanaka Satoshi, Kato Hidekazu, Oya-Ito Tomoko, Nakatochi Masahiro, Aleksic Branko, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES     2022.6

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    Language:Japanese   Publisher:Psychiatry and Clinical Neurosciences  

    Aim: Eating disorders (EDs) are complex, multifactorial psychiatric conditions. Previous studies identified pathogenic copy number variations associated with NDDs (NDD-CNVs) in ED patients. However, no statistical evidence for an association between NDD-CNVs and EDs has been demonstrated. Therefore, we examined whether NDD-CNVs confer risk for EDs. Methods: Using array comparative genomic hybridization (aCGH), we conducted a high-resolution CNV analysis of 71 severe female ED patients and 1045 female controls. According to the American College of Medical Genetics guidelines, we identified NDD-CNVs or pathogenic/likely pathogenic CNVs in NDD-linked loci. Gene set analysis was performed to examine the involvement of synaptic dysfunction in EDs. Clinical data were retrospectively examined for ED patients with NDD-CNVs. Results: Of the samples analyzed with aCGH, 70 severe ED patients (98.6%) and 1036 controls (99.1%) passed our quality control filtering. We obtained 189 and 2539 rare CNVs from patients and controls, respectively. NDD-CNVs were identified in 10.0% (7/70) of patients and 2.3% (24/1036) of controls. Statistical analysis revealed a significant association between NDD-CNVs and EDs (odds ratio = 4.69, P = 0.0023). NDD-CNVs in ED patients included 45,X and deletions at KATNAL2, DIP2A, PTPRT, RBFOX1, CNTN4, MACROD2, and FAM92B. Four of these genes were related to synaptic function. In gene set analysis, we observed a nominally significant enrichment of rare exonic CNVs in synaptic signaling in ED patients (odds ratio = 2.55, P = 0.0254). Conclusion: Our study provides the first preliminary evidence that NDD-CNVs may confer risk for severe EDs. The pathophysiology may involve synaptic dysfunction.

    DOI: 10.1111/pcn.13430

    Web of Science

    Scopus

    PubMed

  2. Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder.

    Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka K, Torii Y, Nakamura Y, Tanaka S, Imaeda M, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y, Ogawa N, Iritani S, Hayashi Y, Lo T, Otgonbayar G, Furuta S, Iwata N, Ikeda M, Saito T, Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Itokawa M, Arai M, Miyashita M, Toriumi K, Ohi K, Shioiri T, Kitaichi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Sasaki T, Tochigi M, Nishimura F, Yamasue H, Kuwabara H, Wakuda T, Kato TA, Kanba S, Horikawa H, Usami M, Kodaira M, Watanabe K, Yoshikawa T, Toyota T, Yokoyama S, Munesue T, Kimura R, Funabiki Y, Kosaka H, Jung M, Kasai K, Ikegame T, Jinde S, Numata S, Kinoshita M, Kato T, Kakiuchi C, Yamakawa K, Suzuki T, Hashimoto N, Ishikawa S, Yamagata B, Nio S, Murai T, Son S, Kunii Y, Yabe H, Inagaki M, Goto YI, Okumura Y, Ito T, Arioka Y, Mori D, Ozaki N

    Biological psychiatry     2022.4

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    Language:English  

    DOI: 10.1016/j.biopsych.2022.04.003

    PubMed

  3. Decline of Plasma Concentrations of Interleukin-18 in Severely Malnourished Patients with Anorexia Nervosa: Exploratory Analysis. Reviewed

    Tanaka S, Oya-Ito T, Murakami Y, Saito K, Furuta S, Yu Y, Imaeda M, Kunimoto S, Ozaki N

    Nutrients   Vol. 11 ( 3 )   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/nu11030540

    Scopus

    PubMed

    Other Link: https://res.mdpi.com/d_attachment/nutrients/nutrients-11-00540/article_deploy/nutrients-11-00540.pdf

  4. Regional decrease in gray matter volume is related to body dissatisfaction in anorexia nervosa Reviewed

    Kohmura Kunihiro, Adachi Yasunori, Tanaka Satoshi, Katayama Hiroto, Imaeda Miho, Kawano Naoko, Nishioka Kazuo, Ando Masahiko, Iidaka Tetsuya, Ozaki Norio

    Psychiatry Research Neuroimaging   Vol. 267   page: 51-58   2017.9

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  5. Risk factors for elevated liver enzymes during refeeding of severely malnourished patients with eating disorders: a retrospective cohort study Reviewed

    Miho Imaeda, Satoshi Tanaka, Hiroshige Fujishiro, Saki Kato, Masatoshi Ishigami, Naoko Kawano, Hiroto Katayama, Kunihiro Kohmura, Masahiko Ando, Kazuo Nishioka, Norio Ozaki

    Journal of Eating Disorders   Vol. 4   page: 37   2016.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40337-016-0127-x

    Other Link: https://jeatdisord.biomedcentral.com/track/pdf/10.1186/s40337-016-0127-x

  6. Association of Beck Depression Inventory Score and Temperament and Character Inventory-125 in patients with eating disorders and severe malnutrition Reviewed

    Satoshi Tanaka, Keizo Yoshida, Hiroto Katayama, Kunihiro Kohmura, Naoko Kawano, Miho Imaeda, Saki Kato, Masahiko Ando, Branko Aleksic, Kazuo Nishioka, Norio Ozaki

      Vol. 3   page: 36   2015.11

  7. Social insecurity in relation to orbitofrontal activity in patients with eating disorders: a near-infrared spectroscopy study Reviewed

    Hiroto Katayama, Kunihiro Kohmura, Satoshi Tanaka, Miho Imaeda, Naoko Kawano, Yukihiro Noda, Kazuo Nishioka, Masahiko Ando, Branko Aleksic, Tetsuya Iidaka, Norio Ozaki

    BMC Psychiatry   Vol. 14   page: 173   2014.6

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Presentations 10

  1. 進行期レビー小体型認知症の難治性疼痛などの非運動症状に対して修正型電気けいれん療法が奏功した一例

    岩田邦幸, 関口裕孝, 近藤怜苑, 西山扶, 今枝美穂, 藤城弘樹, 尾崎紀夫

    第179回東海精神神経学会  2021.1.17  東海精神神経学会

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (general)  

  2. 薬物療法に難渋した精神病性うつ病に対して修正型電気けいれん療法が著効した一例

    齋藤翔子, 西山扶, 今枝美穂, 尾崎紀夫

    第179回東海精神神経学会  2021.1.17  東海精神神経学会

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (general)  

  3. 高用量ヒドロモルフォン塩酸塩徐放錠からメサドンへのスイッチングが難治性がん疼痛に対して有効であった一例

    渡邉美菜子, 新保暁子, 杉下美保子, 宮崎雅之, 宮嶋真理, 立石祐子, 原万里子, 今枝美穂, 楊承叡, 向山宣昭, 藤本保志, 安藤雄一, 山田清文

    第25回日本緩和医療学会学術大会  2020.8.9 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Poster presentation  

  4. 重度の低体重を示す神経性やせ症患者における二次性カルニチン欠乏の検討

    今枝美穂, 田中聡, 伊藤(大矢)友子, 藤垣英嗣, 齋藤邦明, 尾崎紀夫

    第23回日本摂食障害学会学術集会  2019.11 

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    Event date: 2019.11

    Venue:国立精神神経医療研究センター  

  5. 抗がん剤治療中に急性リチウム中毒を発症し、血液透析によって意識障害が改善した双極性障害患者の一例

    今枝美穂, 木村宏之, 徳倉達也, 杉下美保子, 新保暁子, 宮崎雅之, 宮嶋真理, 原万里子, 上原圭介, 安藤雄一, 尾崎紀夫

    第32回日本サイコオンコロジー学会総会  2019.10.11 

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    Event date: 2019.10

    Presentation type:Poster presentation  

    Venue:タワーホール船堀  

  6. がん入院患者におけるせん妄発症とインシデント(転倒、チューブ類自己抜去)の関連

    今枝美穂, 足立康則, 木村宏之, 徳倉達也, 小笠原一能, 杉下美保子, 加藤博史, 齊藤名歩, 原万里子, 宮嶋真理, 安藤雄一, 尾崎紀夫

    第31回日本総合病院精神医学会  2018.11.30 

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    Event date: 2018.11 - 2018.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  7. 極度の低体重を示す摂食障害入院患者の臨床的特徴ーEDI-2とBDIを用いた検討

    今枝美穂

    第58回日本児童青年期精神医学会総会  2017.10 

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    Event date: 2017.10

    Venue:東大寺総合文化センター  

  8. 極度の低栄養を伴う摂食障害入院患者の再栄養療法中に生じる肝酵素上昇に関与する要因とその臨床的意義

    今枝美穂, 田中聡, 藤城弘樹, 加藤咲, 石上雅敏, 河野直子, 片山寛人, 幸村州洋, 安藤昌彦, 西岡和郎, 尾崎紀夫

    第113回日本精神神経学会学術総会  2017.6 

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    Event date: 2017.6

    Venue:名古屋国際会議場  

  9. 極度の低体重を示す摂食障害入院患者の肝機能異常についてー再栄養療法中に生じるALT値異常に関与する要因とその臨床的意義

    今枝美穂, 加藤咲, 田中聡, 藤城弘樹, 平田陽子, 河野直子, 石上雅敏, 安藤昌彦, 西岡和郎, 尾崎紀夫

    第19回日本摂食障害学会学術集会  2015.10 

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    Event date: 2015.10

    Venue:パピヨン24  

  10. 摂食障害患者の肝機能異常に関与する要因と予後に関する考察

    今枝美穂, 加藤咲, 平田陽子, 片山寛人, 幸村州洋, 河野直子, 田中聡, 西岡和郎, 尾崎紀夫

    第18回日本摂食障害学会学術集会  2014.9 

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    Event date: 2014.9

    Venue:大阪国際会議場  

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. To elucidate mechanisms of anorexia nervosa and avoindant/restrictive food intake disorder for novel therapy

    Grant number:20K07942  2020.4 - 2023.3

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    Authorship:Coinvestigator(s) 

  2. Secondary carnitine deficiency in severely malnourished patients with eating disorders

    Grant number:19K17087  2019.4 - 2022.3

    Grant-in-Aid for Early-Career Scientists

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )