Updated on 2022/03/17

写真a

 
OMOTE Norihito
 
Organization
Nagoya University Hospital Respiratory Medicine Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 博士(医学) ( 2017.3   名古屋大学 ) 

Research Areas 1

  1. Life Science / Respiratory medicine  / 間質性肺炎、ARDS、COVID-19、COPD

Professional Memberships 5

  1. アメリカ呼吸器学会

  2. 日本内科学会

  3. 日本結核病学会

  4. 日本呼吸器内視鏡学会

  5. 日本呼吸器学会

Awards 1

  1. 日本呼吸ケア・リハビリテーション学会 優秀演題賞

    2010.9   日本呼吸ケア・リハビリテーション学会   特発性肺線維症(IPF)急性増悪と重症肺炎によるALI/ARDSに おける臨床検査成績およびBAL所見の比較検討

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 22

  1. Lung-dominant connective tissue disease: clinical, radiologic and histologic features. Reviewed

    Omote N, Taniguchi H, Kondoh Y, Watanabe N, Sakamoto K, Kimura T, Kataoka K, Johkoh T, Fujimoto K, Fukuoka J, Otani K, Nishiyama O, Hasegawa Y.

    Chest   Vol. 148 ( 6 ) page: 1438-1446   2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  2. Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy. Reviewed

    Omote N, Hashimoto N, Morise M, Sakamoto K, Miyazaki S, Ando A, Nakahara Y, and Hasegawa Y

    International Journal of Chronic Obstructive Pulmonary Disease   Vol. 11 ( 12 ) page: 3541-3547   2017.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  3. Acute respiratory distress syndrome due to severe pulmonary tuberculosis treated with extracorporeal membrane oxygenation: a case report and review of the literature. Reviewed

    Omote N, Kondoh Y, Taniguchi H, Kimura T, Kataoka K, Hasegawa R, Hasegawa Y.

    Respiratory Medicine Case Reports.   Vol. 19   page: 31-33   2016

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. 家族性特発性間質性肺炎の放射線学的・病理学的特徴の検討 Reviewed

    表紀仁、谷口博之、近藤康博、木村智樹、片岡健介、松田俊明、横山俊樹、福岡順也、上甲剛

    陶生医報   ( 29 ) page: 1-5   2013

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  5. Exogenous induction of unphosphorylated PTEN represses TGFβ-induced extracellular matrix expressions in lung fibroblasts. Reviewed

    Kimura M, Hashimoto N, Kusunose M, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.

    Wound Repair and Regeneration   Vol. 25 ( 1 ) page: 86-97   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. Omote N, Imaizumi K, Kawabe T, Hasegawa Y. Direct regulation of TGFβ-induced EMT by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells Reviewed

    Kusunose M, Hashimoto N, Kimura M, Ogata R, Aoyama D, Sakamoto K, Miyazaki S, Ando A, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.

    Cancer Science   Vol. 106 ( 12 ) page: 1693-1704   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers. Reviewed

    Kohnoh T, Hashimoto N, Ando A, Sakamoto K, Miyazaki S, Aoyama D, Kusunose M, Kimura M, Omote N, Imaizumi K, Kawabe T, Hasegawa Y.

    Cancer Cell Int   Vol. 18 ( 16 ) page: 33   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Non-coding RNAs as Regulators of Cellular Senescence in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease. Invited Reviewed

    Omote N, Sauler M

    Frontiers in medicine   Vol. 7   page: 603047   2020

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    Authorship:Lead author   Language:English  

    DOI: 10.3389/fmed.2020.603047

    PubMed

  9. COVID-19-Triggered Acute Exacerbation of IPF, an Underdiagnosed Clinical Entity With Two-Peaked Respiratory Failure: A Case Report and Literature Review Reviewed

    Goto Yosuke, Sakamoto Koji, Fukihara Jun, Suzuki Atsushi, Omote Norihito, Ando Akira, Shindo Yuichiro, Hashimoto Naozumi

    FRONTIERS IN MEDICINE   Vol. 9   page: 815924   2022.2

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  10. Successful Treatment with High-dose Steroids for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Triggered by COVID-19 Reviewed

    Intern Med   Vol. 15;61(2):233-236.   2022.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Invited Reviewed

    Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C Jr, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO.

    Nat Commun.   Vol. 25;13(1):494.   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  12. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Invited Reviewed

    Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N.

    Circulation     2021.7

  13. Usefulness of Respiratory Mechanics and Laboratory Parameter Trends as Markers of Early Treatment Success in Mechanically Ventilated Severe Coronavirus Disease: A Single-Center Pilot Study Invited Reviewed

    Daisuke Kasugai , Masayuki Ozaki , Kazuki Nishida , Hiroaki Hiraiwa , Naruhiro Jingushi , Atsushi Numaguchi, Norihito Omote, Yuichiro Shindo , Yukari Goto

    J Clin Med     2021.6

  14. Usefulness of Respiratory Mechanics and Laboratory Parameter Trends as Markers of Early Treatment Success in Mechanically Ventilated Severe Coronavirus Disease: A Single-Center Pilot Study

    Kasugai Daisuke, Ozaki Masayuki, Nishida Kazuki, Hiraiwa Hiroaki, Jingushi Naruhiro, Numaguchi Atsushi, Omote Norihito, Shindo Yuichiro, Goto Yukari

    JOURNAL OF CLINICAL MEDICINE   Vol. 10 ( 11 )   2021.6

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  15. Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis.

    Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y

    The European respiratory journal     2021.5

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    Language:English  

    DOI: 10.1183/13993003.03397-2020

    PubMed

  16. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state Reviewed

    Omote Norihito, Sakamoto Koji, Li Qin, Schupp Jonas C., Adams Taylor, Ahangari Farida, Chioccioli Maurizio, DeIuliis Giuseppe, Hashimoto Naozumi, Hasegawa Yoshinori, Kaminski Naftali

    PHYSIOLOGICAL REPORTS   Vol. 9 ( 3 ) page: e14727   2021.2

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    Authorship:Lead author   Language:Japanese  

    DOI: 10.14814/phy2.14727

    Web of Science

    PubMed

  17. High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study

    Omote Norihito, Matsuda Naoyuki, Hashimoto Naozumi, Nishida Kazuki, Sakamoto Koji, Ando Akira, Nakahara Yoshio, Nishikimi Mitsuaki, Higashi Michiko, Matsu Shigeyuki, Hasegawa Yoshinori

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 301 - 313   2020.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.82.2.301

    Web of Science

    PubMed

  18. Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory Aberrations

    Cosme C. Jr., McDonough J. E., Adams T., Schupp J. C., Omote N., Ahangari F., Deluliis G., Sakamoto K., Kaminski N.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 201   2020

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    Language:Japanese  

    Web of Science

  19. Repressive role of stabilized hypoxia inducible factor 1 alpha expression on transforming growth factor beta-induced extracellular matrix production in lung cancer cells

    Ando Akira, Hashimoto Naozumi, Sakamoto Koji, Omote Norihito, Miyazaki Shinichi, Nakahara Yoshio, Imaizumi Kazuyoshi, Kawabe Tsutomu, Hasegawa Yoshinori

    CANCER SCIENCE   Vol. 110 ( 6 ) page: 1959 - 1973   2019.6

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  20. An EGFR-mutated Lung Adenocarcinoma Undergoing Squamous Cell Carcinoma Transformation Exhibited a Durable Response to Afatinib

    Sato Mitsuo, Matsui Akira, Shimoyama Yoshie, Omote Norihito, Morise Masahiro, Hase Tetsunari, Tanaka Ichidai, Suzuki Kojiro, Hasegawa Yoshinori

    INTERNAL MEDICINE   Vol. 57 ( 23 ) page: 3429-3432   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.0999-18

    Web of Science

    PubMed

  21. Exogenous induction of unphosphorylated PTEN reduces TGF beta-induced extracellular matrix expressions in lung fibroblasts

    Kimura Motohiro, Hashimoto Naozumi, Kusunose Masaaki, Aoyama Daisuke, Sakamoto Koji, Miyazaki Shinichi, Ando Akira, Omote Norihiro, Imaizumi Kazuyoshi, Kawabe Tsutomu, Hasegawa Yoshinori

    WOUND REPAIR AND REGENERATION   Vol. 25 ( 1 ) page: 86 - 97   2017

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    Language:Japanese  

    DOI: 10.1111/wrr.12506

    Web of Science

  22. Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy

    Omote Norihito, Hashimoto Naozumi, Morise Masahiro, Sakamoto Koji, Miyazaki Shinichi, Ando Akira, Nakahara Yoshio, Hasegawa Yoshinori

    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE   Vol. 12   page: 3541 - 3547   2017

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Books 2

  1. 日本呼吸器学会 難治性びまん性肺疾患の手引き

    本間栄

    株式会社 南江堂  2017 

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    Language:Japanese Book type:Scholarly book

  2. ファーマナビゲーター DIC編

    丸山征郎( Role: Contributor ,  特発性肺線維症(IPF))

    メディカルレビュー社  2014 

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    Language:Japanese Book type:Scholarly book

Presentations 4

  1. Impact of mild to moderate COPD on feasibility and prognosisin non-small cell lung cancer patients who received chemotherapy International conference

    Norihito Omote, Naozumi Hashimoto, Masahiro Morise, Koji Sakamoto, Shinichi Miyazaki, Akira Ando, Yoshinori Hasegawa

    American Thoracic Society International Conference 

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    Event date: 2017.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  2. Exogenous induction of unphosphorylated PTEN reducesTGFb-induced extracellular matrix expressions in lung fibroblasts International conference

    Norihito Omote, Naozumi Hashimoto, Motohiro Kimura, Koji Sakamoto, Miyazaki Shinichi, Akira Ando, Yoshinori Hasegawa

    American Thoracic Society International Conference 

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    Event date: 2017.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  3. Acute Respiratory Distress Syndrome Due to Severe Pulmonary Tuberculosis Treated with Extracorporeal Membrane Oxygenation International conference

    Norihito Omote, Yasuhiro Kondoh, Hiroyuki Taniguchi, Yoshinori Hasegawa

    American Thoracic Society International Conference 

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    Event date: 2017.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  4. The Clinical, Radiological And Pathological Features Of Lung-Dominant Connective Tissue Disease In Cases With Surgical Lung Biopsy International conference

    N. Omote, H. Taniguchi, Y. Kondoh, T. Kimura, K. Kataoka, K. Sakamoto, T. Johkoh, H. Sumikawa, J. Fukuoka

    American Thoracic Society International Conference 

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    Event date: 2015.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 不完全な膠原病所見を有する間質性肺炎の肺組織遺伝子発現解析と診断マーカーの開発

    Grant number:21K20864  2021.8 - 2023.3

    科学研究費助成事業  研究活動スタート支援

    表 紀仁

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    Authorship:Principal investigator 

    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )

    間質性肺炎の発病早期に特発性肺線維症と膠原病に続発する間質性肺炎の鑑別はしばしば困難である。特に不完全な膠原病の臨床所見を有する間質性肺炎症例IPAF(interstitial pneumonia with autoimmune features)がどちらの疾患経過を辿るか分類することは、適切な治療選択を可能とし、間質性肺炎の肺機能や生命予後を改善させると予想される。本研究は、肺組織遺伝子発現プロファイリングによりIPAFの分類・臨床経過を予測できるかを探索する。また多数例での再現性実験を含め、同疾患群における有用な分類・予後マーカーの確立を目指す。