研究者詳細 - 尾上　剛史

論文 - 尾上　剛史

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Continuous glucose monitoring with low-glucose alerts in insulin-treated drivers with diabetes: A randomized crossover study. 査読有り

Maeda R, Onoue T, Mizutani K, Suzuki K, Handa T, Kobayashi T, Iwama S, Miyata T, Sugiyama M, Hagiwara D, Suga H, Kinoshita F, Arima H

Diabetes research and clinical practice 222 巻頁： 112074 2025年2月

Dapagliflozin increased pancreatic beta cell proliferation and insulinogenic index in mice fed a high-fat and high-sodium chloride diet 査読有り

Hirose, T; Takagi, H; Kuno, M; Sasaki, T; Taki, K; Ito, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Hagiwara, D; Iwama, S; Suga, H; Banno, R; Arima, H

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 749 巻頁： 151364 2025年2月

Combined PD-1 and CTLA-4 Blockade Increases the Risks of Multiple Pituitary Hormone Deficiency and Isolated Adrenocorticotropic Deficiency: A Prospective Study. 査読有り

Iwama S, Kobayashi T, Izuchi T, Suzuki K, Murase T, Ando M, Handa T, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Mori S, Sano T, Akamatsu S, Akiyama M, Ishii M, Arima H

Endocrinology and metabolism (Seoul, Korea) 2025年2月

Compensatory mechanisms underlying arginine vasopressin regulation in transient polyuria during pregnancy 査読有り

Tsumura, T; Hagiwara, D; Naito, S; Kondo, Y; Kawaguchi, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Iwama, S; Suga, H; Banno, R; Arima, H

PEPTIDES 184 巻頁： 171352 2025年2月

Guidance on Energy Intake Based on Resting Energy Expenditure and Physical Activity: Effective for Reducing Body Weight in Patients with Obesity 査読有り

Handa, T; Onoue, T; Maeda, R; Mizutani, K; Suzuki, K; Kobayashi, T; Miyata, T; Sugiyama, M; Hagiwara, D; Iwama, S; Suga, H; Banno, R; Arima, H

NUTRIENTS 17 巻 ( 2 ) 2025年1月

A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids 査読有り

Asano, T; Suga, H; Niioka, H; Yukawa, H; Sakakibara, M; Taga, S; Soen, M; Miwata, T; Sasaki, H; Seki, T; Hasegawa, S; Murakami, S; Abe, M; Yasuda, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Hagiwara, D; Iwama, S; Baba, Y; Arima, H

COMMUNICATIONS BIOLOGY 7 巻 ( 1 ) 頁： 1468 2024年12月

Factors associated with acquiring exercise habits through health guidance for metabolic syndrome among middle-aged Japanese workers: A machine learning approach 査読有り

Wan, JW; Wakaba, K; Onoue, T; Tsushita, K; Nakata, Y

PREVENTIVE MEDICINE REPORTS 48 巻頁： 102915 2024年12月

Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet. 査読有り

Sasaki T, Sugiyama M, Kuno M, Miyata T, Kobayashi T, Yasuda Y, Onoue T, Takagi H, Hagiwara D, Iwama S, Suga H, Banno R, Arima H

Physiology & behavior 頁： 114703 2024年9月

Internet of things-based approach for glycemic control in people with type 2 diabetes: A randomized controlled trial 査読有り

Bouchi, R; Izumi, K; Ishizuka, N; Uemura, Y; Ohtsu, H; Miyo, K; Tanaka, S; Satoh-Asahara, N; Hara, K; Odawara, M; Kusunoki, Y; Koyama, H; Onoue, T; Arima, H; Tsushita, K; Watada, H; Kadowaki, T; Ueki, K

JOURNAL OF DIABETES INVESTIGATION 15 巻 ( 9 ) 頁： 1287 - 1296 2024年9月

Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study 査読有り

Okuji, T; Iwama, S; Kobayashi, T; Yasuda, Y; Ito, M; Yamagami, A; Ando, M; Hase, T; Shibata, H; Hatta, T; Zhou, X; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Ando, Y; Hashimoto, N; Arima, H

NAGOYA JOURNAL OF MEDICAL SCIENCE 86 巻 ( 3 ) 頁： 452 - 463 2024年8月

Implementing digital transformation in the revision process for Japan's Model Core Curriculum: A qualitative document analysis 査読有り

Kondo, T; Onoue, T; Kou, S; Asada, Y; Isobe, M; Nishigori, H

MEDICAL TEACHER 46 巻 ( sup1 ) 頁： S53 - S60 2024年6月

Developing competencies relating to information science and technology in Japanese undergraduate medical education 査読有り

Onoue, T; Asada, Y; Imafuku, R; Kou, S; Takami, H; Takahashi, Y; Nomura, O; Saiki, T

MEDICAL TEACHER 46 巻 ( sup1 ) 頁： S31 - S37 2024年6月

Development of medical knowledge content for problem-solving competencies through dialogue with the undergraduate medical education community in Japan 査読有り

Nomura, O; Komatsu, H; Matsuyama, Y; Onoue, T; Ikusaka, M; Okazaki, H; Konishi, Y

MEDICAL TEACHER 46 巻 ( sup1 ) 頁： S61 - S66 2024年6月

Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study 査読有り

Kobayashi, T; Iwama, S; Yamagami, A; Izuchi, T; Suzuki, K; Otake, K; Yasuda, Y; Ando, M; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Hase, T; Nishio, N; Mori, S; Shimokata, T; Sano, T; Niimi, K; Yoshikawa, N; Akamatsu, S; Ando, Y; Akiyama, M; Sone, M; Ishii, M; Arima, H

CANCER IMMUNOLOGY IMMUNOTHERAPY 73 巻 ( 8 ) 頁： 146 2024年6月

Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells. 査読有り

Miwata T, Suga H, Mitsumoto K, Zhang J, Hamada Y, Sakakibara M, Soen M, Ozaki H, Asano T, Miyata T, Kawaguchi Y, Yasuda Y, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Oyadomari S, Arima H

Peptides 173 巻頁： 171151 2024年3月

Effects of Digitization of Self-Monitoring of Blood Glucose Records Using a Mobile App and the Cloud System on Outpatient Management of Diabetes: Single-Armed Prospective Study. 査読有り

Handa T, Onoue T, Kobayashi T, Maeda R, Mizutani K, Yamagami A, Kinoshita T, Yasuda Y, Iwama S, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Azuma Y, Kasai T, Yoshioka S, Kuwatsuka Y, Arima H

JMIR diabetes 9 巻頁： e48019 2024年1月

Development of pituitary dysfunction and destructive thyroiditis is associated with better survival in non-small cell lung cancer patients treated with programmed cell death-1 inhibitors: a prospective study with immortal time bias correction.

Suzuki K, Kobayashi T, Izuchi T, Otake K, Ando M, Handa T, Miyata T, Sugiyama M, Onoue T, Hagiwara D, Suga H, Banno R, Hase T, Inoue M, Ishii M, Arima H, Iwama S

Frontiers in endocrinology 15 巻頁： 1490042 2024年

Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade 査読有り

Yamagami, A; Iwama, S; Kobayashi, T; Zhou, X; Yasuda, Y; Okuji, T; Ito, M; Izuchi, T; Ando, M; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Arima, H

ENDOCRINE JOURNAL 71 巻 ( 5 ) 頁： 515 - 526 2024年

Impact of coronavirus disease 2019 on medical practice in endocrine and metabolic diseases in Japan: a nationwide surveillance study conducted by the Japan Endocrine Society 査読有り

Manaka, K; Kato, S; Sakamoto, R; Yamakage, H; Uema, T; Kawai, S; Shibata, M; Hiratsuka, I; Nakachi, S; Onoue, T; Tsuchiya, T; Fukui, M; Hashimoto, K; Suzuki, A; Makita, N; Ogawa, Y; Arima, H; Satoh-Asahara, N; Masuzaki, H

ENDOCRINE JOURNAL 71 巻 ( 5 ) 頁： 499 - 514 2024年

Influence of previous health guidance history: impact and limitations of a single health guidance session.

Hayase A, Onoue T, Nishida K, Nakata Y, Hayashi F, Marutani M, Sakane N, Okamura T, Matsuzaki K, Kawamura T, Tsushita K

Environmental and occupational health practice 6 巻 ( 1 ) 2024年

Improved glycemic control after the use of flash glucose monitoring accompanied by improved treatment satisfaction in patients with non-insulin-treated type 2 diabetes: A post-hoc analysis of a randomized controlled trial. 査読有り

Hayase A, Onoue T, Kobayashi T, Wada E, Handa T, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Kuwatsuka Y, Ando M, Goto M, Arima H

Primary care diabetes S1751-9918(23)00168-7. 巻 2023年10月

Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation 査読有り

Taga Shiori, Suga Hidetaka, Nakano Tokushige, Kuwahara Atsushi, Inoshita Naoko, Kodani Yu, Nagasaki Hiroshi, Sato Yoshitaka, Tsumura Yusuke, Sakakibara Mayu, Soen Mika, Miwata Tsutomu, Ozaki Hajime, Kano Mayuko, Watari Kenji, Ikeda Atsushi, Yamanaka Mitsugu, Takahashi Yasuhiko, Kitamoto Sachiko, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Yasuda Yoshinori, Hagiwara Daisuke, Iwama Shintaro, Tomigahara Yoshitaka, Kimura Toru, Arima Hiroshi

STEM CELL REPORTS 18 巻 ( 8 ) 頁： 1657 - 1671 2023年8月

Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice 査読有り

Ito Masaaki, Iwama Shintaro, Sugiyama Daisuke, Yasuda Yoshinori, Okuji Takayuki, Kobayashi Tomoko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Miyata Takashi, Sugiyama Mariko, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Nishikawa Hiroyoshi, Arima Hiroshi

SCIENTIFIC REPORTS 13 巻 ( 1 ) 頁： 5939 2023年4月

Generation of hypothalamic neural stem cell-like cells<i> in</i><i> vitro</i> from human pluripotent stem cells 査読有り

Miwata Tsutomu, Suga Hidetaka, Kawaguchi Yohei, Sakakibara Mayu, Kano Mayuko, Taga Shiori, Soen Mika, Ozaki Hajime, Asano Tomoyoshi, Sasaki Hiroo, Miyata Takashi, Yasuda Yoshinori, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Arima Hiroshi

STEM CELL REPORTS 18 巻 ( 4 ) 頁： 869 - 883 2023年4月

4. 医学教育モデル・コア・カリキュラム（令和4年度改訂版）と医師国家試験出題基準との整合招待有り査読有り

小松弘幸, 山脇正永, 生坂政臣, 江頭正人, 小西靖彦, 鈴木敬一郎, 島田昌一, 野村理, 松山泰, 矢野晴美, 山本憲, 尾上剛史, 長谷川仁志, 高見秀樹, 岡崎仁昭

医学教育 54 巻 ( 2 ) 頁： 157 - 163 2023年4月

3．新設された資質・能力「情報・科学技術を活かす能力」招待有り査読有り

西城卓也、淺田義和、今福輪太郎、尾上剛史、黄世捷、高見秀樹、野村理、高橋優三

医学教育 54 巻 ( 2 ) 頁： 149 - 156 2023年4月

Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice 査読有り

Kawaguchi Yohei, Hagiwara Daisuke, Tsumura Tetsuro, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Yasuda Yoshinori, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Grinevich Valery, Arima Hiroshi

JOURNAL OF NEUROENDOCRINOLOGY 35 巻 ( 1 ) 頁： e13223 2022年12月

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. 査読有り

Handa T, Onoue T, Kobayashi T, Wada E, Hayase A, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H

Archives of endocrinology and metabolism 2022年12月

Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency 査読有り

Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Kawaguchi Yohei, Hodai Yuichi, Tsumura Tetsuro, Hagiwara Daisuke, Kobayashi Tomoko, Yasuda Yoshinori, Sugiyama Mariko, Onoue Takeshi, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Katsuki Takeshi, Ando Fumiaki, Uchida Shinichi, Arima Hiroshi

ENDOCRINE JOURNAL 2022年11月

Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state 査読有り

Ozaki Hajime, Suga Hidetaka, Sakakibara Mayu, Soen Mika, Miyake Natsuki, Miwata Tsutomu, Taga Shiori, Nagai Takashi, Kano Mayuko, Mitsumoto Kazuki, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Banno Ryoichi, Iguchi Genzo, Takahashi Yutaka, Muguruma Keiko, Inoue Haruhisa, Arima Hiroshi

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 17381 2022年10月

Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade 査読有り

Kobayashi Tomoko, Iwama Shintaro, Yamagami Ayana, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Zhou Xin, Ando Masahiko, Onoue Takeshi, Miyata Takashi, Sugiyama Mariko, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Ito Takanori, Kikumori Toyone, Inoue Megumi, Ando Yuichi, Masuda Norikazu, Kawashima Hiroki, Hashimoto Naozumi, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 107 巻 ( 10 ) 頁： E4115 - E4123 2022年9月

Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating 査読有り

Sun Runan, Sugiyama Mariko, Wang Sixian, Kuno Mitsuhiro, Sasaki Tomoyuki, Hirose Tomonori, Miyata Takashi, Kobayashi Tomoko, Tsunekawa Taku, Onoue Takeshi, Yasuda Yoshinori, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Suga Hidetaka, Arima Hiroshi

NUTRIENTS 14 巻 ( 18 ) 2022年9月

Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin 査読有り

Ito Yoshihiro, Sun Runan, Yagimuma Hiroshi, Taki Keigo, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Suga Hidetaka, Konishi Hiroyuki, Kiyama Hiroshi, Arima Hiroshi, Banno Ryoichi

DIABETES 71 巻 ( 9 ) 頁： 1902 - 1914 2022年9月

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline 査読有り

Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 107 巻 ( 4 ) 頁： E1620 - E1630 2022年3月

Functional Lactotrophs in Induced Adenohypophysis Differentiated From Human iPS Cells 査読有り

Miyake Natsuki, Nagai Takashi, Suga Hidetaka, Osuka Satoko, Kasai Takatoshi, Sakakibara Mayu, Soen Mika, Ozaki Hajime, Miwata Tsutomu, Asano Tomoyoshi, Kano Mayuko, Muraoka Ayako, Nakanishi Natsuki, Nakamura Tomoko, Goto Maki, Yasuda Yoshinori, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Hagiwara Daisuke, Iwama Shintaro, Iwase Akira, Inoshita Naoko, Arima Hiroshi, Kajiyama Hiroaki

ENDOCRINOLOGY 163 巻 ( 3 ) 2022年3月

Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter] 査読有り

Wada Eri, Onoue Takeshi, Kinoshita Tamaki, Hayase Ayaka, Handa Tomoko, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Goto Motomitsu, Arima Hiroshi

DIABETOLOGIA 65 巻 ( 1 ) 頁： 252 - 253 2022年1月

Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study 査読有り

DIABETOLOGIA 64 巻 ( 10 ) 頁： 2183 - 2192 2021年10月

GABA(B) receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice 査読有り

Sun Runan, Tsunekawa Taku, Hirose Tomonori, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Bettler Bernhard, Arima Hiroshi

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 19296 2021年9月

Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study 査読有り

Furukawa Mariko, Onoue Takeshi, Kato Kiminori, Wada Takashi, Shinohara Yukito, Kinoshita Fumie, Goto Motomitsu, Arima Hiroshi, Tsushita Kazuyo

DIABETIC MEDICINE 38 巻 ( 8 ) 頁： e14607 2021年8月

Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice 査読有り

Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Hodai Yuichi, Kawaguchi Yohei, Hagiwara Daisuke, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Tanabe Katsuya, Tanizawa Yukio, Arima Hiroshi

PITUITARY 24 巻 ( 4 ) 頁： 582 - 588 2021年8月

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice 査読有り

Mizoguchi Akira, Banno Ryoichi, Sun Runan, Yaginuma Hiroshi, Taki Keigo, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Nagai Taku, Yamada Kiyofumi, Arima Hiroshi

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 12873 2021年6月

Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus 査読有り

Muroi Koichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Onoue Takeshi, Arima Hiroshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

DIGESTION 102 巻 ( 4 ) 頁： 554 - 562 2021年6月

CD4(+) T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice 査読有り

Yasuda Yoshinori, Iwama Shintaro, Sugiyama Daisuke, Okuji Takayuki, Kobayashi Tomoko, Ito Masaaki, Okada Norio, Enomoto Atsushi, Ito Sachiko, Yan Yue, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Masahide, Nishikawa Hiroyoshi, Arima Hiroshi

SCIENCE TRANSLATIONAL MEDICINE 13 巻 ( 593 ) 2021年5月

High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice 査読有り

NEUROSCIENCE 461 巻頁： 72 - 79 2021年5月

Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons 査読有り

Hagiwara Daisuke, Tochiya Masayoshi, Azuma Yoshinori, Tsumura Tetsuro, Hodai Yuichi, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

PEPTIDES 139 巻頁： 170517 2021年5月

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. 査読有り

Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H

Journal for immunotherapy of cancer 9 巻 ( 5 ) 2021年5月

Dietary sodium chloride attenuates increased beta-cell mass to cause glucose intolerance in mice under a high-fat diet 査読有り

Taki Keigo, Takagi Hiroshi, Hirose Tomonori, Sun Runan, Yaginuma Hiroshi, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Sakano Daisuke, Kume Shoen, Arima Hiroshi

PLOS ONE 16 巻 ( 3 ) 頁： e0248065 2021年3月

Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice 査読有り

Yaginuma Hiroshi, Banno Ryoichi, Sun Runan, Taki Keigo, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Arima Hiroshi

JOURNAL OF PHARMACOLOGICAL SCIENCES 147 巻 ( 4 ) 頁： 340 - 347 2021年

Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice

Kawaguchi Yohei, Hagiwara Daisuke, Miyata Takashi, Hodai Yuichi, Kurimoto Junki, Takagi Hiroshi, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Grinevich Valery, Arima Hiroshi

SCIENTIFIC REPORTS 10 巻 ( 1 ) 頁： 19730 2020年11月

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Miyata Takashi, Hagiwara Daisuke, Hodai Yuichi, Miwata Tsutomu, Kawaguchi Yohei, Kurimoto Junki, Ozaki Hajime, Mitsumoto Kazuki, Takagi Hiroshi, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Matsumoto Mami, Kawakami Natsuko, Ohno Nobuhiko, Sakamoto Hirotaka, Arima Hiroshi

ISCIENCE 23 巻 ( 10 ) 頁： 101648 2020年10月

Higher level of body mass index (>= 22 kg/m(2)) is a useful predictor of non-insulin requirement in Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus (SPIDDM)

Onoue T., Wada E., Hayase A., Handa T., Furukawa M., Kobayashi T., Goto M., Arima H.

DIABETOLOGIA 63 巻 ( SUPPL 1 ) 頁： S176 - S176 2020年9月

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study 査読有り

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Okuji Takayuki, Ito Masaaki, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Hibi Hideharu, Sone Michihiko, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL FOR IMMUNOTHERAPY OF CANCER 8 巻 ( 2 ) 2020年6月

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions

Sugiyama Mariko, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Komine Okiru, Yamanaka Koji, Arima Hiroshi

NEUROCHEMISTRY INTERNATIONAL 136 巻頁： 104733 2020年6月

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Okada Norio, Iwama Shintaro, Okuji Takayuki, Kobayashi Tomoko, Yasuda Yoshinori, Wada Eri, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Kanda Mitsuro, Yokota Kenji, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Nagino Masato, Kodera Yasuhiro, Fujishiro Mitsuhiro, Hibi Hideharu, Sone Michihiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

BRITISH JOURNAL OF CANCER 122 巻 ( 6 ) 頁： 771 - 777 2020年3月

Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled

Onoue Takeshi, Goto Motomitsu, Wada Eri, Furukawa Mariko, Okuji Takayuki, Okada Norio, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Seino Yusuke, Suga Hidetaka, Banno Ryoichi, Hamada Yoji, Ando Masahiko, Yamamori Etsuko, Arima Hiroshi

PLOS ONE 15 巻 ( 1 ) 頁： e0228004 2020年1月

Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells

Kasai Takatoshi, Suga Hidetaka, Sakakibara Mayu, Ozone Chikafumi, Matsumoto Ryusaku, Kano Mayuko, Mitsumoto Kazuki, Ogawa Koichiro, Kodani Yu, Nagasaki Hiroshi, Inoshita Naoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Takahashi Jun, Arima Hiroshi

CELL REPORTS 30 巻 ( 1 ) 頁： 18 - + 2020年1月

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial

Wada Eri, Onoue Takeshi, Kobayashi Tomoko, Handa Tomoko, Hayase Ayaka, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Okada Norio, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Kuwatsuka Yachiyo, Ando Masahiko, Goto Motomitsu, Arima Hiroshi

BMJ OPEN DIABETES RESEARCH & CARE 8 巻 ( 1 ) 2020年1月

Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion

Takagi Hiroshi, Hagiwara Daisuke, Handa Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Kunihiko, Matsui Shigeyuki, Arima Hiroshi

ENDOCRINE JOURNAL 67 巻 ( 3 ) 頁： 267 - 274 2020年

GABA(B) Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet

Tsunekawa Taku, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Bettler Bernhard, Arima Hiroshi

ISCIENCE 20 巻頁： 337-+ 2019年10月

Improved methods for the differentiation of hypothalamic vasopressin neurons using mouse induced pluripotent stem cells

Mitsumoto Kazuki, Suga Hidetaka, Sakakibara Mayu, Soen Mika, Yamada Tomiko, Ozaki Hajime, Nagai Takashi, Kano Mayuko, Kasai Takatoshi, Ozone Chikafumi, Ogawa Koichiro, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

STEM CELL RESEARCH 40 巻頁： 101572 2019年10月

Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial.

Kobayashi T, Tsushita K, Nomura E, Muramoto A, Kato A, Eguchi Y, Onoue T, Goto M, Muto S, Yatsuya H, Arima H

Journal of diabetes science and technology 13 巻 ( 4 ) 頁： 796 - 798 2019年7月

Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions

Kano Mayuko, Suga Hidetaka, Ishihara Takeshi, Sakakibara Mayu, Soen Mika, Yamada Tomiko, Ozaki Hajime, Mitsumoto Kazuki, Kasai Takatoshi, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

ENDOCRINOLOGY 160 巻 ( 7 ) 頁： 1701 - 1718 2019年7月

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus.

Tochiya M, Hagiwara D, Azuma Y, Miyata T, Morishita Y, Suga H, Onoue T, Tsunekawa T, Takagi H, Ito Y, Iwama S, Goto M, Banno R, Arima H

Neuroscience letters 682 巻頁： 50 - 55 2018年8月

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. 国際誌

Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H

Journal of the Endocrine Society 2 巻 ( 3 ) 頁： 241 - 251 2018年3月

Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol.

Onoue T, Goto M, Kobayashi T, Tominaga T, Ando M, Honda H, Yoshida Y, Tosaki T, Yokoi H, Kato S, Maruyama S, Arima H

Nagoya journal of medical science 79 巻 ( 3 ) 頁： 323 - 329 2017年8月

Sequestosome 1 (SQSTMI/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture

Tominaga Takashi, Goto Motomitsu, Onoue Takeshi, Mizoguchi Akira, Sugiyama Mariko, Tsunekawa Taku, Hagiwara Daisuke, Morishita Yoshiaki, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

NEUROSCIENCE LETTERS 656 巻頁： 103 - 107 2017年8月

PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S, Goto M, Suga H, Arima H

Biochemical and biophysical research communications 488 巻 ( 1 ) 頁： 116 - 121 2017年6月

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia.

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M, Suga H, Sugimura Y, Arima H

EBioMedicine 16 巻頁： 172 - 183 2017年2月

Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus

Onoue Takeshi, Goto Motomitsu, Tominaga Takashi, Sugiyama Mariko, Tsunekawa Taku, Hagiwara Daisuke, Banno Ryoichi, Suga Hidetaka, Sugimura Yoshihisa, Arima Hiroshi

NEUROSCIENCE LETTERS 619 巻頁： 1 - 7 2016年4月

AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat

Shibata Miyuki, Banno Ryoichi, Sugiyama Mariko, Tominaga Takashi, Onoue Takeshi, Tsunekawa Taku, Azuma Yoshinori, Hagiwara Daisuke, Lu Wenjun, Ito Yoshihiro, Goto Motomitsu, Suga Hidetaka, Sugimura Yoshihisa, Oiso Yutaka, Arima Hiroshi

ENDOCRINOLOGY 157 巻 ( 4 ) 頁： 1457 - 1466 2016年4月

Agrp Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Decreased Body Weight and Adiposity in Mice

Shibata Miyuki, Banno Ryoichi, Onoue Takeshi, Tsunekawa Taku, Adachi Koichi, Ito Yoshihiro, Goto Motomitsu, Arima Hiroshi, Oiso Yutaka