日本内分泌学会   評議員

日本糖尿病学会

日本内科学会

医学教育学会

日本内分泌学会

日本神経内分泌学会

日本糖尿病学会

日本肥満学会

米国内分泌学会

米国糖尿病学会

Generation of hypothalamic neural stem cell-like cells<i> in</i><i> vitro</i> from human pluripotent stem cells 査読有り

Miwata Tsutomu, Suga Hidetaka, Kawaguchi Yohei, Sakakibara Mayu, Kano Mayuko, Taga Shiori, Soen Mika, Ozaki Hajime, Asano Tomoyoshi, Sasaki Hiroo, Miyata Takashi, Yasuda Yoshinori, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Arima Hiroshi

STEM CELL REPORTS   18 巻 ( 4 ) 頁： 869 - 883   2023年4月

4. 医学教育モデル・コア・カリキュラム（令和4年度改訂版）と医師国家試験出題基準との整合 招待有り 査読有り

小松 弘幸, 山脇 正永, 生坂 政臣, 江頭 正人, 小西 靖彦, 鈴木 敬一郎, 島田 昌一, 野村 理, 松山 泰, 矢野 晴美, 山本 憲, 尾上 剛史, 長谷川 仁志, 高見 秀樹, 岡崎 仁昭

医学教育   54 巻 ( 2 ) 頁： 157 - 163   2023年4月

3．新設された資質・能力「情報・科学技術を活かす能力」 招待有り 査読有り

西城卓也、淺田義和、今福輪太郎、尾上剛史、黄世捷、高見秀樹、野村理、高橋優三

医学教育   54 巻 ( 2 ) 頁： 149 - 156   2023年4月

Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice 査読有り

Kawaguchi Yohei, Hagiwara Daisuke, Tsumura Tetsuro, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Yasuda Yoshinori, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Grinevich Valery, Arima Hiroshi

JOURNAL OF NEUROENDOCRINOLOGY   35 巻 ( 1 ) 頁： e13223   2022年12月

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. 査読有り

Handa T, Onoue T, Kobayashi T, Wada E, Hayase A, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H

Archives of endocrinology and metabolism     2022年12月

Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency 査読有り

Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Kawaguchi Yohei, Hodai Yuichi, Tsumura Tetsuro, Hagiwara Daisuke, Kobayashi Tomoko, Yasuda Yoshinori, Sugiyama Mariko, Onoue Takeshi, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Katsuki Takeshi, Ando Fumiaki, Uchida Shinichi, Arima Hiroshi

ENDOCRINE JOURNAL     2022年11月

Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state 査読有り

Ozaki Hajime, Suga Hidetaka, Sakakibara Mayu, Soen Mika, Miyake Natsuki, Miwata Tsutomu, Taga Shiori, Nagai Takashi, Kano Mayuko, Mitsumoto Kazuki, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Banno Ryoichi, Iguchi Genzo, Takahashi Yutaka, Muguruma Keiko, Inoue Haruhisa, Arima Hiroshi

SCIENTIFIC REPORTS   12 巻 ( 1 ) 頁： 17381   2022年10月

Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade 査読有り

Kobayashi Tomoko, Iwama Shintaro, Yamagami Ayana, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Zhou Xin, Ando Masahiko, Onoue Takeshi, Miyata Takashi, Sugiyama Mariko, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Ito Takanori, Kikumori Toyone, Inoue Megumi, Ando Yuichi, Masuda Norikazu, Kawashima Hiroki, Hashimoto Naozumi, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   107 巻 ( 10 ) 頁： E4115 - E4123   2022年9月

Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating 査読有り

Sun Runan, Sugiyama Mariko, Wang Sixian, Kuno Mitsuhiro, Sasaki Tomoyuki, Hirose Tomonori, Miyata Takashi, Kobayashi Tomoko, Tsunekawa Taku, Onoue Takeshi, Yasuda Yoshinori, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Suga Hidetaka, Arima Hiroshi

NUTRIENTS   14 巻 ( 18 )   2022年9月

Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin 査読有り

Ito Yoshihiro, Sun Runan, Yagimuma Hiroshi, Taki Keigo, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Suga Hidetaka, Konishi Hiroyuki, Kiyama Hiroshi, Arima Hiroshi, Banno Ryoichi

DIABETES   71 巻 ( 9 ) 頁： 1902 - 1914   2022年9月

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline 査読有り

Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   107 巻 ( 4 ) 頁： E1620 - E1630   2022年3月

Functional Lactotrophs in Induced Adenohypophysis Differentiated From Human iPS Cells 査読有り

Miyake Natsuki, Nagai Takashi, Suga Hidetaka, Osuka Satoko, Kasai Takatoshi, Sakakibara Mayu, Soen Mika, Ozaki Hajime, Miwata Tsutomu, Asano Tomoyoshi, Kano Mayuko, Muraoka Ayako, Nakanishi Natsuki, Nakamura Tomoko, Goto Maki, Yasuda Yoshinori, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Hagiwara Daisuke, Iwama Shintaro, Iwase Akira, Inoshita Naoko, Arima Hiroshi, Kajiyama Hiroaki

ENDOCRINOLOGY   163 巻 ( 3 )   2022年3月

Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter] 査読有り

Wada Eri, Onoue Takeshi, Kinoshita Tamaki, Hayase Ayaka, Handa Tomoko, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Goto Motomitsu, Arima Hiroshi

DIABETOLOGIA   65 巻 ( 1 ) 頁： 252 - 253   2022年1月

Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study 査読有り

Wada Eri, Onoue Takeshi, Kinoshita Tamaki, Hayase Ayaka, Handa Tomoko, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Goto Motomitsu, Arima Hiroshi

DIABETOLOGIA   64 巻 ( 10 ) 頁： 2183 - 2192   2021年10月

GABA(B) receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice 査読有り

Sun Runan, Tsunekawa Taku, Hirose Tomonori, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Bettler Bernhard, Arima Hiroshi

SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁： 19296   2021年9月

Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study 査読有り

Furukawa Mariko, Onoue Takeshi, Kato Kiminori, Wada Takashi, Shinohara Yukito, Kinoshita Fumie, Goto Motomitsu, Arima Hiroshi, Tsushita Kazuyo

DIABETIC MEDICINE   38 巻 ( 8 ) 頁： e14607   2021年8月

Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice 査読有り

Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Hodai Yuichi, Kawaguchi Yohei, Hagiwara Daisuke, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Tanabe Katsuya, Tanizawa Yukio, Arima Hiroshi

PITUITARY   24 巻 ( 4 ) 頁： 582 - 588   2021年8月

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice 査読有り

Mizoguchi Akira, Banno Ryoichi, Sun Runan, Yaginuma Hiroshi, Taki Keigo, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Nagai Taku, Yamada Kiyofumi, Arima Hiroshi

SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁： 12873   2021年6月

Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus 査読有り

Muroi Koichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Onoue Takeshi, Arima Hiroshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

DIGESTION   102 巻 ( 4 ) 頁： 554 - 562   2021年6月

CD4(+) T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice 査読有り

Yasuda Yoshinori, Iwama Shintaro, Sugiyama Daisuke, Okuji Takayuki, Kobayashi Tomoko, Ito Masaaki, Okada Norio, Enomoto Atsushi, Ito Sachiko, Yan Yue, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Masahide, Nishikawa Hiroyoshi, Arima Hiroshi

SCIENCE TRANSLATIONAL MEDICINE   13 巻 ( 593 )   2021年5月

High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice 査読有り

Mizoguchi Akira, Banno Ryoichi, Sun Runan, Yaginuma Hiroshi, Taki Keigo, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Arima Hiroshi

NEUROSCIENCE   461 巻   頁： 72 - 79   2021年5月

Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons 査読有り

Hagiwara Daisuke, Tochiya Masayoshi, Azuma Yoshinori, Tsumura Tetsuro, Hodai Yuichi, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

PEPTIDES   139 巻   頁： 170517   2021年5月

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. 査読有り

Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H

Journal for immunotherapy of cancer   9 巻 ( 5 )   2021年5月

Dietary sodium chloride attenuates increased beta-cell mass to cause glucose intolerance in mice under a high-fat diet 査読有り

Taki Keigo, Takagi Hiroshi, Hirose Tomonori, Sun Runan, Yaginuma Hiroshi, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Sakano Daisuke, Kume Shoen, Arima Hiroshi

PLOS ONE   16 巻 ( 3 ) 頁： e0248065   2021年3月

Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice 査読有り

Yaginuma Hiroshi, Banno Ryoichi, Sun Runan, Taki Keigo, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Arima Hiroshi

JOURNAL OF PHARMACOLOGICAL SCIENCES   147 巻 ( 4 ) 頁： 340 - 347   2021年

Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice

Kawaguchi Yohei, Hagiwara Daisuke, Miyata Takashi, Hodai Yuichi, Kurimoto Junki, Takagi Hiroshi, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Grinevich Valery, Arima Hiroshi

SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁： 19730   2020年11月

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Miyata Takashi, Hagiwara Daisuke, Hodai Yuichi, Miwata Tsutomu, Kawaguchi Yohei, Kurimoto Junki, Ozaki Hajime, Mitsumoto Kazuki, Takagi Hiroshi, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Matsumoto Mami, Kawakami Natsuko, Ohno Nobuhiko, Sakamoto Hirotaka, Arima Hiroshi

ISCIENCE   23 巻 ( 10 ) 頁： 101648   2020年10月

Higher level of body mass index (>= 22 kg/m(2)) is a useful predictor of non-insulin requirement in Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus (SPIDDM)

Onoue T., Wada E., Hayase A., Handa T., Furukawa M., Kobayashi T., Goto M., Arima H.

DIABETOLOGIA   63 巻 ( SUPPL 1 ) 頁： S176 - S176   2020年9月

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study 査読有り

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Okuji Takayuki, Ito Masaaki, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Hibi Hideharu, Sone Michihiko, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL FOR IMMUNOTHERAPY OF CANCER   8 巻 ( 2 )   2020年6月

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions

Sugiyama Mariko, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Komine Okiru, Yamanaka Koji, Arima Hiroshi

NEUROCHEMISTRY INTERNATIONAL   136 巻   頁： 104733   2020年6月

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Okada Norio, Iwama Shintaro, Okuji Takayuki, Kobayashi Tomoko, Yasuda Yoshinori, Wada Eri, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Kanda Mitsuro, Yokota Kenji, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Nagino Masato, Kodera Yasuhiro, Fujishiro Mitsuhiro, Hibi Hideharu, Sone Michihiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

BRITISH JOURNAL OF CANCER   122 巻 ( 6 ) 頁： 771 - 777   2020年3月

Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled

Onoue Takeshi, Goto Motomitsu, Wada Eri, Furukawa Mariko, Okuji Takayuki, Okada Norio, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Seino Yusuke, Suga Hidetaka, Banno Ryoichi, Hamada Yoji, Ando Masahiko, Yamamori Etsuko, Arima Hiroshi

PLOS ONE   15 巻 ( 1 ) 頁： e0228004   2020年1月

Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells

Kasai Takatoshi, Suga Hidetaka, Sakakibara Mayu, Ozone Chikafumi, Matsumoto Ryusaku, Kano Mayuko, Mitsumoto Kazuki, Ogawa Koichiro, Kodani Yu, Nagasaki Hiroshi, Inoshita Naoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Takahashi Jun, Arima Hiroshi

CELL REPORTS   30 巻 ( 1 ) 頁： 18 - +   2020年1月

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial

Wada Eri, Onoue Takeshi, Kobayashi Tomoko, Handa Tomoko, Hayase Ayaka, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Okada Norio, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Kuwatsuka Yachiyo, Ando Masahiko, Goto Motomitsu, Arima Hiroshi

BMJ OPEN DIABETES RESEARCH & CARE   8 巻 ( 1 )   2020年1月

Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion

Takagi Hiroshi, Hagiwara Daisuke, Handa Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Kunihiko, Matsui Shigeyuki, Arima Hiroshi

ENDOCRINE JOURNAL   67 巻 ( 3 ) 頁： 267 - 274   2020年

GABA(B) Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet

Tsunekawa Taku, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Bettler Bernhard, Arima Hiroshi

ISCIENCE   20 巻   頁： 337-+   2019年10月

Improved methods for the differentiation of hypothalamic vasopressin neurons using mouse induced pluripotent stem cells

Mitsumoto Kazuki, Suga Hidetaka, Sakakibara Mayu, Soen Mika, Yamada Tomiko, Ozaki Hajime, Nagai Takashi, Kano Mayuko, Kasai Takatoshi, Ozone Chikafumi, Ogawa Koichiro, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

STEM CELL RESEARCH   40 巻   頁： 101572   2019年10月

Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial.

Kobayashi T, Tsushita K, Nomura E, Muramoto A, Kato A, Eguchi Y, Onoue T, Goto M, Muto S, Yatsuya H, Arima H

Journal of diabetes science and technology   13 巻 ( 4 ) 頁： 796 - 798   2019年7月

Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions

Kano Mayuko, Suga Hidetaka, Ishihara Takeshi, Sakakibara Mayu, Soen Mika, Yamada Tomiko, Ozaki Hajime, Mitsumoto Kazuki, Kasai Takatoshi, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

ENDOCRINOLOGY   160 巻 ( 7 ) 頁： 1701 - 1718   2019年7月

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus.

Tochiya M, Hagiwara D, Azuma Y, Miyata T, Morishita Y, Suga H, Onoue T, Tsunekawa T, Takagi H, Ito Y, Iwama S, Goto M, Banno R, Arima H

Neuroscience letters   682 巻   頁： 50 - 55   2018年8月

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. 国際誌

Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H

Journal of the Endocrine Society   2 巻 ( 3 ) 頁： 241 - 251   2018年3月

Sequestosome 1 (SQSTMI/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture

Tominaga Takashi, Goto Motomitsu, Onoue Takeshi, Mizoguchi Akira, Sugiyama Mariko, Tsunekawa Taku, Hagiwara Daisuke, Morishita Yoshiaki, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

NEUROSCIENCE LETTERS   656 巻   頁： 103 - 107   2017年8月

Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol.

Onoue T, Goto M, Kobayashi T, Tominaga T, Ando M, Honda H, Yoshida Y, Tosaki T, Yokoi H, Kato S, Maruyama S, Arima H

Nagoya journal of medical science   79 巻 ( 3 ) 頁： 323 - 329   2017年8月

PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S, Goto M, Suga H, Arima H

Biochemical and biophysical research communications   488 巻 ( 1 ) 頁： 116 - 121   2017年6月

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia.

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M, Suga H, Sugimura Y, Arima H

EBioMedicine   16 巻   頁： 172 - 183   2017年2月

Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus

Onoue Takeshi, Goto Motomitsu, Tominaga Takashi, Sugiyama Mariko, Tsunekawa Taku, Hagiwara Daisuke, Banno Ryoichi, Suga Hidetaka, Sugimura Yoshihisa, Arima Hiroshi

NEUROSCIENCE LETTERS   619 巻   頁： 1 - 7   2016年4月

AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat

Shibata Miyuki, Banno Ryoichi, Sugiyama Mariko, Tominaga Takashi, Onoue Takeshi, Tsunekawa Taku, Azuma Yoshinori, Hagiwara Daisuke, Lu Wenjun, Ito Yoshihiro, Goto Motomitsu, Suga Hidetaka, Sugimura Yoshihisa, Oiso Yutaka, Arima Hiroshi

ENDOCRINOLOGY   157 巻 ( 4 ) 頁： 1457 - 1466   2016年4月

Agrp Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Decreased Body Weight and Adiposity in Mice

Shibata Miyuki, Banno Ryoichi, Onoue Takeshi, Tsunekawa Taku, Adachi Koichi, Ito Yoshihiro, Goto Motomitsu, Arima Hiroshi, Oiso Yutaka

ENDOCRINE REVIEWS   35 巻 ( 3 ) 頁： .   2014年6月

Insulin-Induced Phosphorylation of Akt Is Mediated Via NADPH Oxidase-Derived Reactive Oxygen Species in the Mouse Hypothalamic Organotypic Cultures

Onoue Takeshi, Goto Motomitsu, Tsunekawa Taku, Shibata Miyuki, Adachi Koichi, Ito Yoshihiro, Bonno Ryoichi, Arima Hiroshi, Oiso Yutaka

ENDOCRINE REVIEWS   35 巻 ( 3 ) 頁： .   2014年6月

MAPK Signaling Is Inhibited By Mitogen-Activated Protein Kinase Phosphatase 1 in Mouse Hypothalamus

Adachi Koichi, Goto Motomitsu, Onoue Takeshi, Tsunekawa Taku, Shibata Miyuki, Hagimoto Shigeru, Ito Yoshihiro, Banno Ryoichi, Suga Hidetaka, Sugimura Yoshihisa, Arima Hiroshi, Oiso Yutaka

ENDOCRINE REVIEWS   35 巻 ( 3 ) 頁： .   2014年6月

Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus

Adachi Koichi, Goto Motomitsu, Onoue Takeshi, Tsunekawa Taku, Shibata Miyuki, Hagimoto Shigeru, Ito Yoshihiro, Banno Ryoichi, Suga Hidetaka, Sugimura Yoshihisa, Oiso Yutaka, Arima Hiroshi

NEUROSCIENCE LETTERS   569 巻   頁： 49 - 54   2014年5月

甲状腺クリーゼー妙に意識が悪い 心房細動と思ったら……

近藤猛、尾上剛史（ 担当： 共著）

救急外来、ここだけの話、医学書院  2021年 

肥満症に対する内科的治療

尾上剛史、有馬寛（ 担当： 共著）

臨床外科、医学書院  2021年 

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

Taku Tsunekawa, Ryoichi Banno, Akira Mizoguchi, Mariko Sugiyama, Takashi Tominaga, Takeshi Onoue, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Yoshihisa Sugimura, Hiroshi Arima  

EBIOMEDICINE16 巻   頁： 172 - 183   2017年2月

インスリン非使用2型糖尿病患者に対するFGMによる糖代謝改善効果の詳細および対象者特性と効果との関連の検討

早瀬絢香、尾上剛史、和田絵梨、木下珠希、半田朋子、小林朋子、鍬塚 八千代、安藤 昌彦、後藤資実、有馬寛

第65回日本糖尿病学会学術集会  2022年5月14日 

原発性アルドステロン症術後に重度高カリウム血症を生じた１例

浜田 雄大,尾上 剛史, 津村 哲郎, 有馬 寛

第246回日本内科学会東海地方会  2022年2月20日 

IoTを活用した糖尿病生活習慣改善支援～七福神アプリ～ 招待有り

第41回日本肥満学会 

安静時代謝の変動に対する摂取エネルギー／消費エネルギー比の影響の検討

第41回日本肥満学会 

低血糖～予防可能な代謝障害～に起因する運転リスクとその対策 招待有り

第56回日本交通科学学会総 

入院患者の血糖管理 招待有り

第21回日本病院総合診療医学会学術総会 

IoTを用いた生活習慣病へのアプローチ 招待有り

尾上剛史　津下一代　有馬寛

第40回　日本肥満学会 

Randomized controlled trial to evaluate the effects of anaglipitin, a DPP-4 inhibitor, on blood lipids in type 2 diabetic patients 国際会議

Takeshi Onoue, Mariko Furukawa, Eri Wada, Norio Okada, Tomoko Kobayashi, Shintaro Iwama, Motomitsu Goto, Masahiko Ando, Hiroshi Arima

Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study 国際会議

第100回米国内分泌学会 

IoT(Internet of things)システムを用いた療養指導強化による糖代謝改善についての検討-クリニック通院患者を対象とした前向き研究-

尾上剛史 他.

第60回日本糖尿病学会年次学術集会 

NADPH oxidase-derived reactive oxygen species (ROS) enhance insulin signaling in mouse hypothalamus 国際会議

第96回米国内分泌学会 

診療録直結型大規模糖尿病レジストリを用いた糖尿病合併症抑制のための治療法に関するエビデンス創出のための研究

2020年8月 - 現在

循環器疾患・糖尿病等生活習慣病対策実用化研究事業 

壮年期就労者を対象とした生活習慣病予防のための動機付け支援の技術開発に関する研究

2019年4月 - 現在

循環器疾患・糖尿病等生活習慣病対策実用化研究事業 

臨床実習II　糖尿病・内分泌内科

2022

臨床実習　糖尿病・内分泌内科

2022

選択特別講義（生活習慣病）

2022

臓器別講義　糖尿病・内分泌

2021

選択特別講義（生活習慣病）

2021

臨床実習　糖尿病・内分泌内科

2021

現代医療と生命科学

2021

臨床実習II　糖尿病・内分泌内科

2021

臨床実習　糖尿病・内分泌内科

2020

選択特別講義（生活習慣病）

2020

臨床実習II　糖尿病・内分泌内科

2020

現代医療と生命科学

2020

選択特別講義（生活習慣病）

2019

臨床実習　糖尿病・内分泌内科

2019

PBL

2019

臨床実習II　糖尿病・内分泌内科

2019

PBL

2018