Faculty Profiles - HATTORI Norifumi

Papers - HATTORI Norifumi

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直腸癌術後異時性肝・肺転移に対して化学療法開始後1年7ヵ月でconversion切除し得た1例

深田浩志, 上原圭, 小倉淳司, 村田悠記, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 75 ( 9 ) page： A221 - A221 2022.9

直腸癌術前集学的治療の成績:Watch & Waitを含めて局所進行直腸癌に対する術前化学療法を基本とした治療戦略Tripletレジメンの臨床経験とWatch and Wait strategyの安全な導入

小倉淳司, 上原圭, 村田悠記, 鳥居直矢, 小林龍太朗, 深田浩志, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 75 ( 9 ) page： A54 - A54 2022.9

Prognostic Value of a Modified Albumin-Bilirubin Score Designed for Patients with Esophageal Squamous Cell Carcinoma After Radical Resection. International journal

Takahiro Shinozuka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Masahiko Koike, Yasuhiro Kodera

Annals of surgical oncology Vol. 29 ( 8 ) page： 4889 - 4896 2022.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The albumin-bilirubin (ALBI) score was originally developed to assess the severity of liver dysfunction in patients with hepatocellular carcinoma and has subsequently been used as a prognostic marker for that disease. Here, we examined the value of the preoperative ALBI score as a prognostic marker for patients with esophageal squamous cell carcinoma (ESCC) after radical esophagectomy. METHODS: We retrospectively analyzed data from 449 patients who underwent curative resection for ESCC. The ALBI score was calculated as (log10 serum bilirubin [μmol/l] × 0.66) + (serum albumin [g/l] × - 0.0852). Receiver operating characteristic curve analysis was used to define a preoperative modified ALBI (mALBI) score for patient stratification. RESULTS: Of the 449 ESCC patients, 232 and 217 were assigned to mALBI Grade 1 or Grade 2 groups based on preoperative ALBI scores of ≤ - 3.33 or > - 3.33, respectively. Preoperative mALBI grade was significantly associated with age, excessive alcohol consumption, squamous cell carcinoma antigen level, and clinical disease stage. The mALBI Grade 2 group had significantly shorter disease-specific and recurrence-free survival than the mALBI Grade 1 group. Multivariate analysis demonstrated that mALBI Grade 2 was an independent prognostic factor for disease-specific survival (hazard ratio 1.86, 95% confidence interval 1.18-2.93, P = 0.0074). In most subgroup analyses, mALBI Grade 2 was associated with a greater risk of disease-specific death. CONCLUSIONS: mALBI grade serves as a simple and useful prognostic marker for disease-specific survival in patients with ESCC after radical esophagectomy.

DOI： 10.1245/s10434-022-11654-6

Web of Science

PubMed

ASO Visual Abstract: Prognostic Value of a Modified Albumin-Bilirubin Grade Designed for Patients with Esophageal Squamous Cell Carcinoma after Radical Resection. International journal

Takahiro Shinozuka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Masahiko Koike, Yasuhiro Kodera

Annals of surgical oncology Vol. 29 ( 8 ) page： 4899 - 4899 2022.8

胃癌術後早期ドレーンアミラーゼ値の有用性早期治療介入にむけて

中西香企, 神田光郎, 田中千恵, 清水大, 猪川祥邦, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本消化器外科学会総会 Vol. 77回 page： O6 - 4 2022.7

Expression of cellular retinoic acid binding protein 1 predicts peritoneal recurrence of gastric cancer. International journal

Kazuki Sakata, Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera

International journal of oncology Vol. 60 ( 6 ) 2022.6

Language：English Publishing type：Research paper (scientific journal)

To improve the outcome of gastric cancer, novel markers that predict postoperative prognosis are required. For this purpose, the function of cellular retinoic acid binding protein 1 (CRABP1) in gastric cancer cells was investigated and it was determined whether it serves as a novel biomarker for gastric cancer. Reverse transcription‑quantitative (RT‑q)PCR and a PCR‑array method were used to determine whether the expression of CRABP1 mRNA in gastric cancer cell lines correlated with the expression of cancer‑related genes. The correlations of CRABP1 mRNA expression in tissues with clinicopathological factors of 230 patients who underwent radical gastrectomy were further evaluated. CRABP1 mRNA levels varied among gastric cancer cell lines and showed significant positive correlations with numerous epithelial‑mesenchymal transition factors. Additionally, CRABP1 knockdown significantly suppressed the proliferation, migration and invasion of gastric cancer cell lines. In a mouse xenograft model of peritoneal metastasis of gastric cancer, it was found that the total weight of disseminated nodules was lower in the group, in which CRABP1 mRNA levels were knocked down compared with those of the untransfected group. Disease‑free survival (DFS) was significantly shorter in patients with high expression of CRABP1, and multivariate analysis of DFS revealed that high expression of CRABP1 in the tumor area and lymph node metastasis served as an independent factor associated with poor prognosis. High expression of CRABP1 in cancer tissues was associated with a greater incidence of peritoneal recurrences after curative gastrectomy. These findings indicated that CRABP1 contributes to the malignant phenotype of gastric cancer cells and may serve as a biomarker for prognosing recurrence after curative resection, particularly peritoneal dissemination.

DOI： 10.3892/ijo.2022.5353

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PubMed

Lysosomal-associated membrane protein family member 5 promotes the metastatic potential of gastric cancer cells.

Shinichi Umeda, Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 25 ( 3 ) page： 558 - 572 2022.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Metastatic gastric cancer (GC) has a poor prognosis, and elucidating the molecular mechanisms involved in metastasis may lead to the development of novel therapeutic modalities. METHODS: Transcriptome analysis of surgically resected metastatic tissue from GC patients and noncancerous tissue was performed to identify novel metastasis-related genes. Analyses of in vitro cell function, apoptosis, the cell cycle and cancer stemness were performed using GC cell lines with a stable knockout of a candidate gene. In vivo percutaneous, peritoneal dissemination and liver metastasis xenograft models were also generated. PCR array and proteome analyses were performed. Expression of the candidate gene was analyzed in GC tissues from 300 patients. RESULTS: Lysosomal Associated Membrane Protein Family Member 5 (LAMP5) was upregulated in the metastatic tissues. LAMP5 knockout significantly suppressed proliferation, invasion, and migration of GC cells and increased apoptosis, cell cycle arrest and cancer stemness. LAMP5 knockout virtually suppressed tumor growth in in vivo percutaneous, peritoneal dissemination and liver metastasis models. EMT- and autophagy-related genes were associated with LAMP5. High LAMP5 mRNA levels were significantly associated with a worse prognosis. CONCLUSION: LAMP5 plays a vital role in metastasis formation and may be a promising novel target of drug development for metastatic GC in the future.

DOI： 10.1007/s10120-022-01284-y

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PubMed

がんトランスレーショナルリサーチ外科臨床検体を用いたトランスクリプトーム解析からの癌治療抗体医薬開発研究

神田光郎, 清水大, 中西香企, 田中千恵, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科系連合学会誌 Vol. 47 ( 3 ) page： 401 - 401 2022.5

腹腔鏡下直腸癌手術におけるエネルギーデバイスの選択腹腔鏡下直腸癌手術におけるエネルギーデバイスの選択電気メスを中心とした立場から

上原圭, 小倉淳司, 村田悠記, 小林龍太郎, 神原祐一, 深田浩志, 服部憲史, 中山吾郎, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 横山幸浩, 江畑智希

日本外科系連合学会誌 Vol. 47 ( 3 ) page： 413 - 413 2022.5

切除可能同時性肝転移症例の治療戦略肝実質温存術式の有用性

三品拓也, 水野隆史, 上原圭, 小倉淳司, 村田悠記, 小池佳勇, 神原祐一, 西村元伸, 小林龍太朗, 服部憲史, 中山吾郎, 國料俊男, 伊神剛, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 横山幸浩, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 122回 page： SF - 7 2022.4

進行直腸癌に対する治療戦略【International】所進行直腸癌に対する術前化学療法におけるbevacizumabの意義の検討

小倉淳司, 上原圭, 村田悠記, 小池佳男, 三品拓也, 神原祐一, 西村元伸, 小林龍太郎, 服部憲史, 中山吾郎, 横山幸浩, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 122回 page： PD - 1 2022.4

高齢者の上部消化管癌に対する治療方針高齢者機能評価から考える高齢者胃癌に対する治療法

田中千恵, 中西香企, 梅田晋一, 清水大, 猪川祥邦, 高見秀樹, 服部憲史, 神田光郎, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 122回 page： WS - 4 2022.4

骨盤内臓全摘術後の骨盤死腔炎のリスク因子から考える対策法

小林龍太朗, 上原圭, 小倉淳司, 村田悠記, 小池佳勇, 三品拓也, 神原祐一, 西村元伸, 服部憲史, 中山吾郎, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡邊伸元, 横山幸浩, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 122回 page： DP - 4 2022.4

骨盤内臓全摘術後の骨盤死腔炎のリスク因子から考える対策法

日本外科学会定期学術集会抄録集 Vol. 122回 page： DP - 4 2022.4

進行直腸癌に対する治療戦略【International】所進行直腸癌に対する術前化学療法におけるbevacizumabの意義の検討

日本外科学会定期学術集会抄録集 Vol. 122回 page： PD - 1 2022.4

食道扁平上皮癌予後マーカーとしてのOPLAH発現

清水大, 神田光郎, 小池聖彦, 佐藤雄亮, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 田中千恵, 中山吾郎, 本山悟, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 122回 page： DP - 5 2022.4

切除可能同時性肝転移症例の治療戦略肝実質温存術式の有用性

日本外科学会定期学術集会抄録集 Vol. 122回 page： SF - 7 2022.4

ウィズコロナ時代のオンライン補完型外科臨床実習

高見秀樹, 宮田一志, 渡辺伸元, 柴田雅央, 小倉淳司, 清水大, 服部憲史, 菊森豊根, 江畑智希, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 122回 page： DP - 6 2022.4

Drain Amylase Concentrations at 3 h After Gastrectomy Enhance Early Prediction of Postoperative Peripancreatic Inflammatory Fluid Collection. International journal

Koki Nakanishi, Mitsuro Kanda, Chie Tanaka, Shigeomi Takeda, Katsuhito Tanaka, Dai Shimizu, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera

World journal of surgery Vol. 46 ( 3 ) page： 648 - 655 2022.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Despite numerous studies of peripancreatic inflammatory fluid collection (PIFC) that report on the relevance of the drain amylase concentration (D-AMY), early prediction using this assay is problematic. This study aimed to investigate the clinical significance of measuring the D-AMY at 3 h after gastrectomy (POD0) for gastric cancer. METHODS: This retrospective analysis included consecutive patients who underwent gastrectomy combined with peripancreatic lymph node dissection. The predictive value of D-AMY on POD0 and postoperative day 1 (POD1) for clinically relevant PIFC was evaluated together or individually. RESULTS: Analyses were performed in 204 patients. Twenty (9.8%) patients experienced PIFC. D-AMY cutoffs of 721 IU/L on POD0 and 1695 IU/L on POD1 were determined using the receiver operating characteristic curve analysis for predicting PIFC. The D-AMY on POD0 had higher sensitivity (80%) but lower specificity (66.3%) for prediction of PIFC, compared with those of D-AMY on POD1 (65%, 89.1%, respectively). When combination marker analysis was performed, the highest risk group (D-AMY ≥ the cutoff values of POD0 and POD1) were associated with an elevated rate of occurrence (44%) and a high positive likelihood ratio (7.36) compared with those of the single cutoff group. The lowest risk group (D-AMY < the cutoff values on POD0 and POD1) was associated with a low rate of occurrence (2.5%) and low negative likelihood ratio (0.24) compared with those of the single cutoff group. CONCLUSIONS: Combined measurements of D-AMYs on POD0 and POD1 enhanced early prediction of PIFC after gastrectomy.

DOI： 10.1007/s00268-021-06401-z

Web of Science

PubMed

The significance of the time to arterial perfusion in intraoperative ICG angiography during colorectal surgery. Reviewed International journal

Toshisada Aiba, Kay Uehara, Atsushi Ogura, Aya Tanaka, Yoshihiko Yonekawa, Norifumi Hattori, Goro Nakayama, Yasuhiro Kodera, Tomoki Ebata, Masato Nagino

Surgical endoscopy Vol. 35 ( 12 ) page： 7227 - 7235 2021.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Intraoperative indocyanine green angiography (ICG-A) is a promising tool to confirm blood supply; however, the assessment is difficult without clear demarcation. In this study, the clinical impact of the time to arterial perfusion (TAP) on anastomotic leakage (AL) was evaluated, especially in patients without ICG demarcation. METHODS: The TAP was assessed using ICG-A during colorectal surgery in 110 patients. ICG demarcation required changing the transection line, and the TAP was measured at the new stump. The patients were divided into marginal flow (MF) and direct flow (DF) groups according to the arterial route. Delayed TAP was defined as the third quartile or slower TAP in each group. RESULTS: Sixty-six patients (60%) were classified into the MF group, including 64 patients who underwent rectal or sigmoid resection with high ligation of the inferior mesenteric artery. The cut-off value of the delayed TAP in the MF group was significantly slower than that in the DF group (30 and 22 s, respectively, p < 0.001). In the entire cohort, the transection line was changed in 2 patients, resulting in no AL. Nevertheless, AL still developed in 6 patients (5.4%), 5 of whom were in the MF group, and delayed TAP was found in 5 of 6 patients. Delayed TAP was significantly associated with AL in the MF group (p = 0.046). CONCLUSIONS: In patients without ICG demarcation, delayed TAP might be helpful for predicting the high-risk patients with AL in the MF group; however, performing diverting stoma or strictly careful observation might be a realistic reaction.

DOI： 10.1007/s00464-020-08185-0

Web of Science

PubMed

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Papers - HATTORI Norifumi