Updated on 2024/08/20
博士（医学） （ 2017.7 名古屋大学 ）
Healthcare Administration
在留外国人医療
choriocarcinoma
Life Science / Medical management and medical sociology / Healthcare Administration
Life Science / Obstetrics and gynecology / choriocarcinoma
日本公衆衛生学会
東海公衆衛生学会
日本産科婦人科学会
日本婦人科腫瘍学会
日本絨毛性疾患研究会
日本産科婦人科学会 ダイバーシティ・人材育成推進委員会
2023.7 - 2025.5
Committee type：Academic society
Increased number of live births by migrant mothers shows areal inequality in Japan: A descriptive study. Reviewed
Nishino K, Inthaphatha S, Yamamoto E
SSM - population health Vol. 23 page： 101447 2023.9
Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma Reviewed
Nishino Kimihiro, Nishiko Yuki, Shibata Mayu, Oda Yukari, Watanabe Eri, Niimi Kaoru, Yamamoto Eiko, Kajiyama Hiroaki
PLACENTA Vol. 117 page： 109 - 117 2022.1
Short tandem repeat analysis to identify the causative pregnancy of high-risk gestational trophoblastic neoplasia: Molar versus nonmolar pregnancy and its relation to the outcome Reviewed
Nishino Kimihiro, Yamamoto Eiko, Oda Yukari, Watanabe Eri, Niimi Kaoru, Yamamoto Toshimichi, Kajiyama Hiroaki
PLACENTA Vol. 112 page： 28 - 35 2021.9
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma Reviewed
Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Sekiya Yoko, Yamashit Yoriko, Kikkawa Fumitaka
ONCOLOGY REPORTS Vol. 38 ( 1 ) page： 440 - 448 2017.7
Proposal for Classifying the Emetogenicity of Oral Anticancer Agents with a Focus on PARP Inhibitors: A Prospective, Observational, Multicenter Study (JASCC-CINV 2002).
Yamamoto S, Tsuchiya M, Iihara H, Hayasaki Y, Hori K, Kumakura Y, Watanabe D, Sakai H, Nakagawa S, Kudoh A, Oishi H, Kado N, Go M, Mashima K, Uchida T, Yasue M, Maeda A, Nishino K, Matsumoto K, Sato S, Ueda Y, Tomio K, Hayashi K, Takenaka M, Mori M, Kajiyama H, Bomoto Y, Suzuki S, Ishihara T, Suzuki A, Abe M
Journal of Cancer Vol. 15 ( 6 ) page： 1487 - 1497 2024
Oda, Y; Niimi, K; Yoshida, K; Tamauchi, S; Yokoi, A; Yasui, Y; Nishiko, Y; Shibata, M; Shimizu, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Yamamoto, E; Kajiyama, H
BMC CANCER Vol. 23 ( 1 ) page： 1103 2023.11
Nguyen, TTT; Nishino, K; Le, LTH; Inthaphatha, S; Yamamoto, E; Billeaud, C
NUTRIENTS Vol. 15 ( 21 ) 2023.11
A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab.
Niimi K, Yamamoto E, Oda Y, Nishiko Y, Shibata M, Nishino K, Kajiyama H
Taiwanese journal of obstetrics & gynecology Vol. 62 ( 5 ) page： 745 - 748 2023.9
Factors associated with pentavalent vaccine coverage among 12-23-month-old children in Afghanistan: A cross-sectional study
Frozanfar Muhammad Kamel, Hamajima Nobuyuki, Fayaz Said Hafizullah, Rahimzad Abdullah Darman, Stanekzai Hedayatullah, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko
PLOS ONE Vol. 18 ( 8 ) page： e0289744 2023.8
Period shaming behavior among male students in Luang Prabang Province, Lao People's Democratic Republic: A cross-sectional study
Inthaphatha Souphalak, Isin-Xiong Leyla, Louangpradith Viengsakhone, Xiong Valee, Xaitengcha Vue, Phengsavanh Alongkone, Nishino Kimihiro, Hamajima Nobuyuki, Yamamoto Eiko
PLOS ONE Vol. 18 ( 7 ) page： e0288145 2023.7
Causes of death, three delays, and factors associated with Delay 1 among maternal deaths in Myanmar: The maternal death surveillance in 2019
Tun Khine Khine, Inthaphatha Souphalak, Soe Myint Moh, Nishino Kimihiro, Hamajima Nobuyuki, Yamamoto Eiko
MIDWIFERY Vol. 121 page： 103657 2023.6
Assessment of the underlying causes of adult deaths using a short version of verbal autopsy in Xaiyabouli Province, Lao People's Democratic Republic
Thanavanh Bounbouly, Hamajima Nobuyuki, Sida Kaiyason, Duangdy Kene, Latsamy Lasavong, Senaphane Khounsavath, Louangpradith Viengsakhone, Sadettan Souphaphone, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko
BMC PUBLIC HEALTH Vol. 23 ( 1 ) page： 560 2023.3
Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma
Watanabe Eri, Yokoi Akira, Yoshida Kosuke, Sugiyama Mai, Kitagawa Masami, Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Yamamoto Yusuke, Kajiyama Hiroaki
CANCER MEDICINE Vol. 12 ( 4 ) page： 4543 - 4556 2023.2
Factors associated with positive cancer screening for the uterine cervix and breast in Jakarta Province, Indonesia: a cross-sectional study
Sirait Lady Margaretha Febriany, Hamajima Nobuyuki, Suzuki Yunosuke, Wahyuningsih Endang Sri, Oktavia Dwi, Widyastuti, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko
BMC CANCER Vol. 22 ( 1 ) page： 1309 2022.12
Epidemiologic study on gestational trophoblastic diseases in Japan.
Yamamoto E, Nishino K, Niimi K, Ino K
Journal of gynecologic oncology Vol. 33 ( 6 ) page： e72 2022.11
INVESTIGATION OF NK CELL IMMUNITY SURROUNDING CHORIOCARCINOMA
Shibata Mayu, Niimi Kaoru, Yasui Yuuko, Nishiko Yuuki, Oda Yukari, Nishino Kimihiro, Yamamoto Eiko, Kajiyama Hiroaki
PLACENTA Vol. 128 page： 126 - 126 2022.10
UNIQUE GENOMIC PROFILES OF CHORIOCARCINOMA BASED ON WHOLE EXOME SEQUENCING ANALYSIS
Oda Yukari, Niimi Kaoru, Yasui Yuko, Nishiko Yuki, Shibata Mayu, Nishino Kimihiro, Yamamoto Eiko, Kajiyama Hiroaki
PLACENTA Vol. 128 page： 129 - 129 2022.10
Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi-institutional retrospective study
Ikeda Yoshiki, Yoshihara Masato, Yoshikawa Nobuhisa, Tamauchi Satoshi, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS Vol. 157 ( 2 ) page： 437 - 443 2022.5
Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-beta 1/thrombospondin-1 axis
Kitami Kazuhisa, Yoshihara Masato, Tamauchi Satoshi, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Ikeda Yoshiki, Yokoi Akira, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Nawa Akihiro, Enomoto Atsushi, Kajiyama Hiroaki
MATRIX BIOLOGY Vol. 109 page： 70 - 90 2022.5
Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis
Ikeda Yoshiki, Yoshihara Masato, Yoshikawa Nobuhisa, Yokoi Akira, Tamauchi Satoshi, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki
BMC WOMENS HEALTH Vol. 22 ( 1 ) page： 80 2022.3
Vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer via THBS1
Kitami Kazuhisa, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Nawa Akihiro, Kajiyama Hiroaki
CANCER SCIENCE Vol. 113 page： 729 - 729 2022.2
Chemical library-based drug repositioning strategy for choriocarcinoma therapy
Watanabe Eri, Yokoi Akira, Yoshida Kosuke, Yamamoto Yusuke, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki
CANCER SCIENCE Vol. 113 page： 1501 - 1501 2022.2
Laparoscopic pelvic surgery after reconstructive surgery with vertical rectus abdominis muscle flap: A case report.
Nishino K, Ikeda Y, Kitami K, Niimi K, Kajiyama H
International journal of surgery case reports Vol. 90 page： 106706 2022.1
Clinical effects of cervical conization with positive margins in cervical cancer
Nagao Yukari, Yokoi Akira, Yoshida Kosuke, Sumi Masanori, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 23288 2021.12
The current situation of health services for hydatidiform mole in Cambodia
Yamamoto Eiko, Kanal Koum, Soeung Sann Chan, Fujita Noriko, Krang Sidonn, Long-Hay Puthik, Nishino Kimihiro, Niimi Kaoru, Hamajima Nobuyuki
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 47 ( 10 ) page： 3652 - 3660 2021.10
Core 2 beta 1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity
Nakamura Kenichi, Niimi Kaoru, Yamamoto Eiko, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Kajiyama Hiroaki, Kikkawa Fumitaka
BIOCHEMISTRY AND BIOPHYSICS REPORTS Vol. 26 page： 100951 2021.7
Next-generation genome sequencing of a matched normal-tumor pair from a patient with intractable gestational choriocarcinoma: A case report
Niimi Kaoru, Yamamoto Eiko, Morita Sachi, Morikawa Maki, Hattori Hikaru, Hatakeyama Miki, Morita Mami, Nishino Kimihiro, Oda Yukari, Watanabe Eri, Yamamoto Toshimichi, Kajiyama Hiroaki, Kikkawa Fumitaka
MOLECULAR AND CLINICAL ONCOLOGY Vol. 15 ( 1 ) page： 143 2021.7
Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer
Yoshida Kosuke, Yoshikawa Nobuhisa, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki
CANCER CELL INTERNATIONAL Vol. 21 ( 1 ) page： 314 2021.6
Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
Hattori Satomi, Yoshikawa Nobuhisa, Mogi Kazumasa, Yoshida Kosuke, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kajiyama Hiroaki
CURRENT ONCOLOGY Vol. 28 ( 3 ) page： 1663 - 1672 2021.6
A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review
Nishino Kimihiro, Yamamoto Eiko, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Toshimichi, Kajiyama Hiroaki
JOURNAL OF OVARIAN RESEARCH Vol. 14 ( 1 ) page： 56 2021.4
Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance
Yoshida Kosuke, Yokoi Akira, Sugiyama Mai, Oda Shingo, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Yokoi Tsuyoshi, Kajiyama Hiroaki
ONCOGENE Vol. 40 ( 7 ) page： 1255 - 1268 2021.2
The role of chrXq27.3 miRNA cluster in advanced ovarian clear cell carcinoma
Yoshida Kosuke, Yokoi Akira, Yoshihara Masato, Tamauchi Satoshi, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Kikkawa Fumitaka, Kajiyama Hiroaki
CANCER SCIENCE Vol. 112 page： 291 - 291 2021.2
Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis.
Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F
F&S science Vol. 1 ( 2 ) page： 195 - 205 2020.11
Evaluation of a routine second curettage for hydatidiform mole: a cohort study
Yamamoto Eiko, Nishino Kimihiro, Niimi Kaoru, Watanabe Eri, Oda Yukari, Ino Kazuhiko, Kikkawa Fumitaka
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 6 ) page： 1178 - 1186 2020.6
The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study
Yamamoto Eiko, Tien Dat Minh, Sekiya Yoko, Tamakoshi Koji, Xuan Phuoc Nguyen, Nishino Kimihiro, Kotani Kaoru Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Quang Thanh Le, Kikkawa Fumitaka
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 2 ) page： 183 - 191 2020.5
The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma
Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Kajiyama Hiroaki
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 7135 2020.4
The Therapeutic Effects of Goreisan, a Traditional Japanese Herbal Medicine, on Lower-Limb Lymphedema after Lymphadenectomy in Gynecologic Malignancies: A Case Series Study
Yoshikawa Nobuhisa, Kajiyama Hiroaki, Otsuka Naoki, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Utsumi Fumi, Shibata Kiyosumi, Kikkawa Fumitaka
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE Vol. 2020 page： 6298293 2020.4
The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer
Yoshida Kosuke, Kajiyama Hiroaki, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 2 ) page： 384 - 390 2020.2
Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age
Hanatani Maya, Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kawai Michiyasu, Kajiyama Hiroaki, Kikkawa Fumitaka
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 1 ) page： 187 - 194 2020.1
The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia
Sato Shizuka, Yamamoto Eiko, Niimi Kaoru, Ino Kazuhiko, Nishino Kimihiro, Suzuki Shiro, Kotani Tomomi, Kajiyama Hiroaki, Kikkawa Fumitaka
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 1 ) page： 203 - 209 2020.1
Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer
Yoshida Kosuke, Kajiyama Hiroaki, Inami Eri, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka
IN VIVO Vol. 34 ( 1 ) page： 109 - 116 2020
Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma
Shimbo Akiko, Kajiyama Hiroaki, Tamauchi Satoshi, Yoshikawa Nobuhisa, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Kikkawa Fumitaka
ONCOLOGY REPORTS Vol. 42 ( 6 ) page： 2323 - 2332 2019.12
Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background
Yoshida Kosuke, Yokoi Akira, Kagawa Takumi, Oda Shingo, Hattori Satomi, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Kajiyama Hiroaki, Yokoi Tsuyoshi, Kikkawa Fumitaka
CARCINOGENESIS Vol. 40 ( 12 ) page： 1435 - 1444 2019.12
COMPREHENSIVE MIRNA SEQUENCING OF SQUAMOUS CELL CARCINOMA ARISING FROM OVARIAN MATURE TERATOMA
Yoshida K., Yokoi A., Tamauchi S., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 29 page： A544 - A545 2019.11
REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY
Tamauchi S., Kajiyama H., Osuka S., Moriyama Y., Yoshihara M., Iyoshi S., Yoshida K., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 29 page： A269 - A270 2019.11
Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study
Tamauchi Satoshi, Kajiyama Hiroaki, Moriyama Yoshinori, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 45 ( 10 ) page： 2082 - 2087 2019.10
Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma
Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Yoshikawa Nobuhisa, Nishino Kimihiro, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 24 ( 8 ) page： 950 - 956 2019.8
Does postoperative prophylactic irradiation of para-aortic lymph nodes reduce the risk of recurrence in uterine cervical cancer with positive pelvic lymph nodes?
Yoshida K, Kajiyama H, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Utsumi F, Niimi K, Suzuki S, Kikkawa F
International journal of clinical oncology Vol. 24 ( 5 ) page： 567 - 574 2019.5
Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database
Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Nishino Kimihiro, Niimi Kaoru, Mizuno Mika, Yoshikawa Nobuhisa, Kawai Michiyasu, Oguchi Hidenori, Mizuno Kimio, Yamamuro Osamu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 2 ) page： 193 - 198 2019.5
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study
Tamauchi Satoshi, Kajiyama Hiroaki, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Vol. 219 ( 4 ) page： 385.e1 - 385.e7 2018.10
ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY
NIimi Kaoru, Ikeda Yoshinori, Nishino Kimihiro, Yamamoto Eiko, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E29-E29 2018.9
GENETIC STUDY ON ORIGINS OF CHORIOCARCINOMAS BY SHORT TANDEM REPEAT ANALYSIS
Nishino Kimihiro, Nakamura Kenichi, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Yamamoto Toshimichi, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E88-E89 2018.9
CLINICAL CHARACTERISTICS OF PSTT AND ETT IN JAPAN
Niimi K., Yamamoto E., Nishino K., Nakamura K., Ikeda Y., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 28 page： 919 - 919 2018.9
SHORT TANDEM REPEAT ANALYSIS DISTINGUISHING THE GENOTYPE OF CHORIOARCINOMA
Nishino K., Yamamoto E., Watanabe E., Nakamura K., Ikeda Y., Niimi K., Yamamoto T., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 28 page： 920 - 920 2018.9
ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY
Nakamura K., Kaoru N., Ikeda Y., Nishino K., Yamamoto E., KIkkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 28 page： 195 - 195 2018.9
PROPENSITY SCORE ADJUSTED ANALYSIS OF PROPHYLACTIC IRRADIATION TO PARA-AORTIC LYMPH NODE AFTER RADICAL HYSTERECTOMY FOR UTERINE CERVICAL CANCER.
Yoshida K., Yoshihara M., Ikeda Y., Yoshikawa N., Nishino K., Utumi F., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 28 page： 447 - 447 2018.9
EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY ON CLINICAL OUTCOMES IN SMALL CELL CARCINOMA OF THE UTERINE CERVIX
Ikeda Y., Kajiyama H., Yoshida K., Yoshikawa N., Nishino K., Utsumi F., Niimi K., Suzuki S., Kawai M., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 28 page： 294 - 294 2018.9
The upregulated expression of vascular endothelial growth factor in surgically treated patients with recurrent/radioresistant cervical cancer of the uterus
Yoshida Kosuke, Suzuki Shiro, Sakata Jun, Utsumi Fumi, Niimi Kaoru, Yoshikawa Nobuhisa, Nishino Kimihiro, Shibata Kiyosumi, Kikkawa Fumitaka, Kajiyama Hiroaki
ONCOLOGY LETTERS Vol. 16 ( 1 ) page： 515-521 2018.7
Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary.
Yoshikawa N, Teshigawara T, Ikeda Y, Nishino K, Sakata J, Utsumi F, Niimi K, Sekiya R, Suzuki S, Kawai M, Shibata K, Kikkawa F, Kajiyama H
Oncotarget Vol. 9 ( 44 ) page： 27564-27573 2018.6
Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation.
Nishino K, Koda S, Kataoka N, Takamatsu S, Nakano M, Ikeda S, Kamamatsu Y, Morishita K, Moriwaki K, Eguchi H, Yamamoto E, Kikkawa F, Tomita Y, Kamada Y, Miyoshi E
Oncotarget Vol. 9 ( 16 ) page： 12732-12744 2018.2
The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours.
Kajiyama H, Suzuki S, Yoshihara M, Nishino K, Yoshikawa N, Utsumi F, Niimi K, Mizuno M, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Nagasaka T, Shibata K, Kikkawa F
Oncotarget Vol. 9 ( 5 ) page： 6298-6307 2018.1
A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-beta derived from ovarian cancer
Fujikake Kayo, Kajiyama Hiroaki, Yoshihara Masato, Nishino Kimihiro, Yoshikawa Nobuhisa, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Mitsui Hiroko, Shibata Kiyosumi, Senga Takeshi, Kikawa Fumitaka
ONCOLOGY REPORTS Vol. 39 ( 1 ) page： 193 - 200 2018.1
The role of N-acetylg lucosaminyltransferase IVa in choriocarcinoma progression
Nishino Kimihiro, Yamamoto Eiko, Nakamura Kenichi, Niimi Kaoru, Kikkawa Fumitaka
CANCER SCIENCE Vol. 109 page： 254-254 2018.1
ROLE OF GLYCOSYLTRANSFERASE C2GNT FOR THE EVASION MECHANISM OF NATURAL KILLER CELL IMMUNITY IN THE CHORIOCARCINOMA CELL
Nakamura K., Niimi K., NIshino K., Yamamoto E., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 27 page： 1357-1357 2017.11
Establishment and characterization of cell lines derived from complete hydatidiform mole
Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol. 40 ( 3 ) page： 614 - 622 2017.9
Spontaneous regression of gestational trophoblastic neoplasia
Niimi Kaoru, Yamamoto Eiko, Nishino Kimihiro, Fujiwara Sawako, Ino Kazuhiko, Kikkawa Fumitaka
GYNECOLOGIC ONCOLOGY REPORTS Vol. 21 page： 98 - 100 2017.8
c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling
Sekiya Yoko, Yamamoto Eiko, Niimi Kaoru, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka
ONCOLOGY Vol. 92 ( 5 ) page： 299 - 310 2017
産婦人科の実際 第70巻12号11月臨時増刊号 図解 分子メカニズムから理解する婦人科がんの薬物療法
西野公博 新美薫 山本英子（ Role： Joint author , 絨毛性疾患）
金原出版株式会社 2021.11
在留外国人妊婦の不安・負荷・アンメットニーズを包括的に理解するための基盤研究
Grant number：24K13287 2024.4 - 2027.3
科学研究費助成事業 基盤研究(C)
西野 公博, 山本 英子
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
少子化が進む日本において、在留外国人妊婦による出生件数が近年増加しているが、在留外国人妊婦は妊娠、分娩にあたり、どのような点を不安や不満に思い、困難に感じ、それらがどのような負荷となって表れているのか、増加する在留外国人妊婦による出生に対して、医療従事者、医療施設、国（政府）や地方自治体などの医療行政機関は、在留外国人妊婦の不安やニーズに十分に対応できているのか、こうした問いに対して、本研究では、厚生労働省人口動態調査の調査票情報の利用や、医療施設、及び、在留外国人妊婦へのアンケート調査を通じて、答えやヒントとなるものを見出すことを目的として、研究を行う。
Grant number：24K13288 2024.4 - 2028.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
Grant number：23KK0169 2023.9 - 2029.3
Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (International Collaborative Research)
Authorship：Coinvestigator(s)
Grant number：18K16764 2018.4 - 2021.3
科学研究費助成事業 若手研究
西野 公博
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
ホモシステインによるアポトーシスに着目した難治性絨毛癌に対する新規治療法の開発
Grant number：21K16767 2021.4 - 2024.3
科学研究費助成事業 若手研究
西野 公博
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
難治性絨毛癌患者の予後を改善させるべく、絨毛癌に対する化学療法において中心的役割を果たすメトトレキサート（Methotrexate, MTX）に着目し、MTXの既知の抗腫瘍効果である葉酸代謝経路阻害とは別の、細胞内ホモシステイン濃度上昇作用に注目し、ホモシステインが絨毛癌細胞のアポトーシスを誘導することが考えられないかという仮説を立て、研究を実施する。
・MTX投与によるホモシステイン濃度の上昇についての検討
１．絨毛癌細胞内ホモシステイン濃度の測定
MTX投与により絨毛癌細胞内ホモシステイン濃度が上昇するか検討するため、絨毛癌細胞株Jar、BeWo、及び、JEG-3の培地にそれぞれ、PBS（コントロールとして用いる）とMTXを添加し、絨毛癌細胞内ホモシステイン濃度を測定を行った。それぞれの絨毛癌細胞を5000個播種し、24時間培養後、PBS、及び、１μMのMTXを添加し、48時間培養した後、細胞抽出液を回収した。細胞抽出液のホモシステイン濃度定量は、セルバイオラボ社のホモシステインELISAキットを用いた。結果は、いずれの絨毛癌細胞株においても、MTX添加により、絨毛癌細胞内ホモシステイン濃度の低下がみられ、予想に反するものであった。播種する絨毛癌細胞数、添加するMTX濃度、MTX添加時間など、様々な組み合わせで条件検討を試みたが、一定の傾向を示す結果は得られなかった。これらの要因として、MTX添加により死滅した絨毛癌細胞が細胞抽出液を回収する段階で除去されてしまうことが一因と考えられた。そこで、MTX投与後の絨毛癌細胞培養上清中ホモシステイン濃度の変化を検討するプランに変更した。
２．絨毛癌細胞培養上清中ホモシステイン濃度の測定
予備検討として、絨毛癌細胞培養上清中のホモシステイン濃度が正確に測定できるかまず検討することとした。24wellディッシュにJarを5000個播種し、オーバーナイトで培養した。培養上清を除去し、さらにオーバーナイトで培養した。このとき、培養上清は100μLとし、培養上清を全量回収た。回収した培養上清の原液、5倍希釈、10倍希釈したものを用意し、ホモシステイン濃度を測定したところ、希釈倍率に比例して、ホモステイン濃度の低下が認められ、絨毛癌細胞培養上清中のホモシステイン濃度が測定できることを確認した。
絨毛癌細胞培養上清中のホモシステイン濃度の測定が可能であることは判明したが、実際にMTXを投与し、その濃度がどのように変化するのかはまだ検討できていないため、さらにMTXに対して耐性を示す絨毛癌細胞細胞株を使用した比較実験がまだ行えていないため。
MTXを投与し、絨毛癌細胞培養上清中のホモシステイン濃度がどのように変化するのか検討する。MTXに対して耐性を示す絨毛癌細胞細胞株を使用し、この絨毛癌細胞細胞株がオリジナルの絨毛癌細胞細胞株とどのように異なる反応を示すか、すなわち、MTXを添加したときの培養上清中ホモステイン濃度がどのように変化するか検討する。
