Updated on 2024/08/20

写真a

 
NISHINO Kimihiro
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
External link

Degree 1

  1. 博士(医学) ( 2017.7   名古屋大学 ) 

Research Interests 3

  1. Healthcare Administration

  2. 在留外国人医療

  3. choriocarcinoma

Research Areas 2

  1. Life Science / Medical management and medical sociology  / Healthcare Administration

  2. Life Science / Obstetrics and gynecology  / choriocarcinoma

Professional Memberships 5

  1. 日本公衆衛生学会

  2. 東海公衆衛生学会

  3. 日本産科婦人科学会

  4. 日本婦人科腫瘍学会

  5. 日本絨毛性疾患研究会

Committee Memberships 1

  1. 日本産科婦人科学会   ダイバーシティ・人材育成推進委員会  

    2023.7 - 2025.5   

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    Committee type:Academic society

 

Papers 67

  1. Increased number of live births by migrant mothers shows areal inequality in Japan: A descriptive study. Reviewed

    Nishino K, Inthaphatha S, Yamamoto E

    SSM - population health   Vol. 23   page: 101447   2023.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ssmph.2023.101447

    PubMed

  2. Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma Reviewed

    Nishino Kimihiro, Nishiko Yuki, Shibata Mayu, Oda Yukari, Watanabe Eri, Niimi Kaoru, Yamamoto Eiko, Kajiyama Hiroaki

    PLACENTA   Vol. 117   page: 109 - 117   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.placenta.2021.11.005

    Web of Science

    PubMed

  3. Short tandem repeat analysis to identify the causative pregnancy of high-risk gestational trophoblastic neoplasia: Molar versus nonmolar pregnancy and its relation to the outcome Reviewed

    Nishino Kimihiro, Yamamoto Eiko, Oda Yukari, Watanabe Eri, Niimi Kaoru, Yamamoto Toshimichi, Kajiyama Hiroaki

    PLACENTA   Vol. 112   page: 28 - 35   2021.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.placenta.2021.06.015

    Web of Science

    PubMed

  4. N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma Reviewed

    Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Sekiya Yoko, Yamashit Yoriko, Kikkawa Fumitaka

    ONCOLOGY REPORTS   Vol. 38 ( 1 ) page: 440 - 448   2017.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2017.5661

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    PubMed

  5. Proposal for Classifying the Emetogenicity of Oral Anticancer Agents with a Focus on PARP Inhibitors: A Prospective, Observational, Multicenter Study (JASCC-CINV 2002).

    Yamamoto S, Tsuchiya M, Iihara H, Hayasaki Y, Hori K, Kumakura Y, Watanabe D, Sakai H, Nakagawa S, Kudoh A, Oishi H, Kado N, Go M, Mashima K, Uchida T, Yasue M, Maeda A, Nishino K, Matsumoto K, Sato S, Ueda Y, Tomio K, Hayashi K, Takenaka M, Mori M, Kajiyama H, Bomoto Y, Suzuki S, Ishihara T, Suzuki A, Abe M

    Journal of Cancer   Vol. 15 ( 6 ) page: 1487 - 1497   2024

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    Language:English  

    DOI: 10.7150/jca.91675

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  6. Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model

    Oda, Y; Niimi, K; Yoshida, K; Tamauchi, S; Yokoi, A; Yasui, Y; Nishiko, Y; Shibata, M; Shimizu, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Yamamoto, E; Kajiyama, H

    BMC CANCER   Vol. 23 ( 1 ) page: 1103   2023.11

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  7. Strong Negative Association between Cesarean Delivery and Early Initiation of Breastfeeding Practices among Vietnamese Mothers-A Secondary Analysis of the Viet Nam Sustainable Development Goal Indicators on Children and Women Survey

    Nguyen, TTT; Nishino, K; Le, LTH; Inthaphatha, S; Yamamoto, E; Billeaud, C

    NUTRIENTS   Vol. 15 ( 21 )   2023.11

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  8. A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab.

    Niimi K, Yamamoto E, Oda Y, Nishiko Y, Shibata M, Nishino K, Kajiyama H

    Taiwanese journal of obstetrics & gynecology   Vol. 62 ( 5 ) page: 745 - 748   2023.9

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    Language:English  

    DOI: 10.1016/j.tjog.2023.07.019

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  9. Factors associated with pentavalent vaccine coverage among 12-23-month-old children in Afghanistan: A cross-sectional study

    Frozanfar Muhammad Kamel, Hamajima Nobuyuki, Fayaz Said Hafizullah, Rahimzad Abdullah Darman, Stanekzai Hedayatullah, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko

    PLOS ONE   Vol. 18 ( 8 ) page: e0289744   2023.8

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  10. Period shaming behavior among male students in Luang Prabang Province, Lao People's Democratic Republic: A cross-sectional study

    Inthaphatha Souphalak, Isin-Xiong Leyla, Louangpradith Viengsakhone, Xiong Valee, Xaitengcha Vue, Phengsavanh Alongkone, Nishino Kimihiro, Hamajima Nobuyuki, Yamamoto Eiko

    PLOS ONE   Vol. 18 ( 7 ) page: e0288145   2023.7

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  11. Causes of death, three delays, and factors associated with Delay 1 among maternal deaths in Myanmar: The maternal death surveillance in 2019

    Tun Khine Khine, Inthaphatha Souphalak, Soe Myint Moh, Nishino Kimihiro, Hamajima Nobuyuki, Yamamoto Eiko

    MIDWIFERY   Vol. 121   page: 103657   2023.6

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  12. Assessment of the underlying causes of adult deaths using a short version of verbal autopsy in Xaiyabouli Province, Lao People's Democratic Republic

    Thanavanh Bounbouly, Hamajima Nobuyuki, Sida Kaiyason, Duangdy Kene, Latsamy Lasavong, Senaphane Khounsavath, Louangpradith Viengsakhone, Sadettan Souphaphone, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko

    BMC PUBLIC HEALTH   Vol. 23 ( 1 ) page: 560   2023.3

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  13. Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

    Watanabe Eri, Yokoi Akira, Yoshida Kosuke, Sugiyama Mai, Kitagawa Masami, Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Yamamoto Yusuke, Kajiyama Hiroaki

    CANCER MEDICINE   Vol. 12 ( 4 ) page: 4543 - 4556   2023.2

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  14. Factors associated with positive cancer screening for the uterine cervix and breast in Jakarta Province, Indonesia: a cross-sectional study

    Sirait Lady Margaretha Febriany, Hamajima Nobuyuki, Suzuki Yunosuke, Wahyuningsih Endang Sri, Oktavia Dwi, Widyastuti, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko

    BMC CANCER   Vol. 22 ( 1 ) page: 1309   2022.12

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  15. Epidemiologic study on gestational trophoblastic diseases in Japan.

    Yamamoto E, Nishino K, Niimi K, Ino K

    Journal of gynecologic oncology   Vol. 33 ( 6 ) page: e72   2022.11

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    Language:English  

    DOI: 10.3802/jgo.2022.33.e72

    PubMed

  16. INVESTIGATION OF NK CELL IMMUNITY SURROUNDING CHORIOCARCINOMA

    Shibata Mayu, Niimi Kaoru, Yasui Yuuko, Nishiko Yuuki, Oda Yukari, Nishino Kimihiro, Yamamoto Eiko, Kajiyama Hiroaki

    PLACENTA   Vol. 128   page: 126 - 126   2022.10

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  17. UNIQUE GENOMIC PROFILES OF CHORIOCARCINOMA BASED ON WHOLE EXOME SEQUENCING ANALYSIS

    Oda Yukari, Niimi Kaoru, Yasui Yuko, Nishiko Yuki, Shibata Mayu, Nishino Kimihiro, Yamamoto Eiko, Kajiyama Hiroaki

    PLACENTA   Vol. 128   page: 129 - 129   2022.10

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  18. Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi-institutional retrospective study

    Ikeda Yoshiki, Yoshihara Masato, Yoshikawa Nobuhisa, Tamauchi Satoshi, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 157 ( 2 ) page: 437 - 443   2022.5

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  19. Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-beta 1/thrombospondin-1 axis

    Kitami Kazuhisa, Yoshihara Masato, Tamauchi Satoshi, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Fujimoto Hiroki, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Ikeda Yoshiki, Yokoi Akira, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Nawa Akihiro, Enomoto Atsushi, Kajiyama Hiroaki

    MATRIX BIOLOGY   Vol. 109   page: 70 - 90   2022.5

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  20. Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis

    Ikeda Yoshiki, Yoshihara Masato, Yoshikawa Nobuhisa, Yokoi Akira, Tamauchi Satoshi, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    BMC WOMENS HEALTH   Vol. 22 ( 1 ) page: 80   2022.3

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  21. Vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer via THBS1

    Kitami Kazuhisa, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Nawa Akihiro, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 113   page: 729 - 729   2022.2

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    Language:Japanese  

    Web of Science

  22. Chemical library-based drug repositioning strategy for choriocarcinoma therapy

    Watanabe Eri, Yokoi Akira, Yoshida Kosuke, Yamamoto Yusuke, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 113   page: 1501 - 1501   2022.2

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  23. Laparoscopic pelvic surgery after reconstructive surgery with vertical rectus abdominis muscle flap: A case report.

    Nishino K, Ikeda Y, Kitami K, Niimi K, Kajiyama H

    International journal of surgery case reports   Vol. 90   page: 106706   2022.1

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    DOI: 10.1016/j.ijscr.2021.106706

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  24. Clinical effects of cervical conization with positive margins in cervical cancer

    Nagao Yukari, Yokoi Akira, Yoshida Kosuke, Sumi Masanori, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 23288   2021.12

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  25. The current situation of health services for hydatidiform mole in Cambodia

    Yamamoto Eiko, Kanal Koum, Soeung Sann Chan, Fujita Noriko, Krang Sidonn, Long-Hay Puthik, Nishino Kimihiro, Niimi Kaoru, Hamajima Nobuyuki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 10 ) page: 3652 - 3660   2021.10

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  26. Core 2 beta 1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity

    Nakamura Kenichi, Niimi Kaoru, Yamamoto Eiko, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Kajiyama Hiroaki, Kikkawa Fumitaka

    BIOCHEMISTRY AND BIOPHYSICS REPORTS   Vol. 26   page: 100951   2021.7

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  27. Next-generation genome sequencing of a matched normal-tumor pair from a patient with intractable gestational choriocarcinoma: A case report

    Niimi Kaoru, Yamamoto Eiko, Morita Sachi, Morikawa Maki, Hattori Hikaru, Hatakeyama Miki, Morita Mami, Nishino Kimihiro, Oda Yukari, Watanabe Eri, Yamamoto Toshimichi, Kajiyama Hiroaki, Kikkawa Fumitaka

    MOLECULAR AND CLINICAL ONCOLOGY   Vol. 15 ( 1 ) page: 143   2021.7

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  28. Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer

    Yoshida Kosuke, Yoshikawa Nobuhisa, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Kajiyama Hiroaki

    CANCER CELL INTERNATIONAL   Vol. 21 ( 1 ) page: 314   2021.6

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  29. Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer

    Hattori Satomi, Yoshikawa Nobuhisa, Mogi Kazumasa, Yoshida Kosuke, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kajiyama Hiroaki

    CURRENT ONCOLOGY   Vol. 28 ( 3 ) page: 1663 - 1672   2021.6

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  30. A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review

    Nishino Kimihiro, Yamamoto Eiko, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Toshimichi, Kajiyama Hiroaki

    JOURNAL OF OVARIAN RESEARCH   Vol. 14 ( 1 ) page: 56   2021.4

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  31. Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance

    Yoshida Kosuke, Yokoi Akira, Sugiyama Mai, Oda Shingo, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Yokoi Tsuyoshi, Kajiyama Hiroaki

    ONCOGENE   Vol. 40 ( 7 ) page: 1255 - 1268   2021.2

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  32. The role of chrXq27.3 miRNA cluster in advanced ovarian clear cell carcinoma

    Yoshida Kosuke, Yokoi Akira, Yoshihara Masato, Tamauchi Satoshi, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Kikkawa Fumitaka, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 291 - 291   2021.2

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    Language:Japanese  

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  33. Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis.

    Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F

    F&S science   Vol. 1 ( 2 ) page: 195 - 205   2020.11

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    DOI: 10.1016/j.xfss.2020.09.001

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  34. Evaluation of a routine second curettage for hydatidiform mole: a cohort study

    Yamamoto Eiko, Nishino Kimihiro, Niimi Kaoru, Watanabe Eri, Oda Yukari, Ino Kazuhiko, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 6 ) page: 1178 - 1186   2020.6

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  35. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study

    Yamamoto Eiko, Tien Dat Minh, Sekiya Yoko, Tamakoshi Koji, Xuan Phuoc Nguyen, Nishino Kimihiro, Kotani Kaoru Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Quang Thanh Le, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 183 - 191   2020.5

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  36. The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma

    Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 7135   2020.4

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  37. The Therapeutic Effects of Goreisan, a Traditional Japanese Herbal Medicine, on Lower-Limb Lymphedema after Lymphadenectomy in Gynecologic Malignancies: A Case Series Study

    Yoshikawa Nobuhisa, Kajiyama Hiroaki, Otsuka Naoki, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Utsumi Fumi, Shibata Kiyosumi, Kikkawa Fumitaka

    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   Vol. 2020   page: 6298293   2020.4

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  38. The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer

    Yoshida Kosuke, Kajiyama Hiroaki, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 2 ) page: 384 - 390   2020.2

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  39. Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age

    Hanatani Maya, Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kawai Michiyasu, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 187 - 194   2020.1

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  40. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato Shizuka, Yamamoto Eiko, Niimi Kaoru, Ino Kazuhiko, Nishino Kimihiro, Suzuki Shiro, Kotani Tomomi, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

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  41. Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer

    Yoshida Kosuke, Kajiyama Hiroaki, Inami Eri, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    IN VIVO   Vol. 34 ( 1 ) page: 109 - 116   2020

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  42. Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma

    Shimbo Akiko, Kajiyama Hiroaki, Tamauchi Satoshi, Yoshikawa Nobuhisa, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Kikkawa Fumitaka

    ONCOLOGY REPORTS   Vol. 42 ( 6 ) page: 2323 - 2332   2019.12

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  43. Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background

    Yoshida Kosuke, Yokoi Akira, Kagawa Takumi, Oda Shingo, Hattori Satomi, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Kajiyama Hiroaki, Yokoi Tsuyoshi, Kikkawa Fumitaka

    CARCINOGENESIS   Vol. 40 ( 12 ) page: 1435 - 1444   2019.12

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  44. COMPREHENSIVE MIRNA SEQUENCING OF SQUAMOUS CELL CARCINOMA ARISING FROM OVARIAN MATURE TERATOMA

    Yoshida K., Yokoi A., Tamauchi S., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A544 - A545   2019.11

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  45. REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY

    Tamauchi S., Kajiyama H., Osuka S., Moriyama Y., Yoshihara M., Iyoshi S., Yoshida K., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A269 - A270   2019.11

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  46. Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study

    Tamauchi Satoshi, Kajiyama Hiroaki, Moriyama Yoshinori, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 10 ) page: 2082 - 2087   2019.10

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  47. Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma

    Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Yoshikawa Nobuhisa, Nishino Kimihiro, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 8 ) page: 950 - 956   2019.8

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  48. Does postoperative prophylactic irradiation of para-aortic lymph nodes reduce the risk of recurrence in uterine cervical cancer with positive pelvic lymph nodes?

    Yoshida K, Kajiyama H, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Utsumi F, Niimi K, Suzuki S, Kikkawa F

    International journal of clinical oncology   Vol. 24 ( 5 ) page: 567 - 574   2019.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-018-1376-2

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  49. Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database

    Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Nishino Kimihiro, Niimi Kaoru, Mizuno Mika, Yoshikawa Nobuhisa, Kawai Michiyasu, Oguchi Hidenori, Mizuno Kimio, Yamamuro Osamu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 193 - 198   2019.5

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  50. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study

    Tamauchi Satoshi, Kajiyama Hiroaki, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   Vol. 219 ( 4 ) page: 385.e1 - 385.e7   2018.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajog.2018.07.021

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  51. ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY

    NIimi Kaoru, Ikeda Yoshinori, Nishino Kimihiro, Yamamoto Eiko, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E29-E29   2018.9

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  52. GENETIC STUDY ON ORIGINS OF CHORIOCARCINOMAS BY SHORT TANDEM REPEAT ANALYSIS

    Nishino Kimihiro, Nakamura Kenichi, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Yamamoto Toshimichi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E88-E89   2018.9

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  53. CLINICAL CHARACTERISTICS OF PSTT AND ETT IN JAPAN

    Niimi K., Yamamoto E., Nishino K., Nakamura K., Ikeda Y., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 919 - 919   2018.9

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  54. PROPENSITY SCORE ADJUSTED ANALYSIS OF PROPHYLACTIC IRRADIATION TO PARA-AORTIC LYMPH NODE AFTER RADICAL HYSTERECTOMY FOR UTERINE CERVICAL CANCER.

    Yoshida K., Yoshihara M., Ikeda Y., Yoshikawa N., Nishino K., Utumi F., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 447 - 447   2018.9

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  55. EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY ON CLINICAL OUTCOMES IN SMALL CELL CARCINOMA OF THE UTERINE CERVIX

    Ikeda Y., Kajiyama H., Yoshida K., Yoshikawa N., Nishino K., Utsumi F., Niimi K., Suzuki S., Kawai M., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 294 - 294   2018.9

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  56. ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY

    Nakamura K., Kaoru N., Ikeda Y., Nishino K., Yamamoto E., KIkkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 195 - 195   2018.9

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  57. SHORT TANDEM REPEAT ANALYSIS DISTINGUISHING THE GENOTYPE OF CHORIOARCINOMA

    Nishino K., Yamamoto E., Watanabe E., Nakamura K., Ikeda Y., Niimi K., Yamamoto T., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 920 - 920   2018.9

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  58. The upregulated expression of vascular endothelial growth factor in surgically treated patients with recurrent/radioresistant cervical cancer of the uterus

    Yoshida Kosuke, Suzuki Shiro, Sakata Jun, Utsumi Fumi, Niimi Kaoru, Yoshikawa Nobuhisa, Nishino Kimihiro, Shibata Kiyosumi, Kikkawa Fumitaka, Kajiyama Hiroaki

    ONCOLOGY LETTERS   Vol. 16 ( 1 ) page: 515-521   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2018.8610

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  59. Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary.

    Yoshikawa N, Teshigawara T, Ikeda Y, Nishino K, Sakata J, Utsumi F, Niimi K, Sekiya R, Suzuki S, Kawai M, Shibata K, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 44 ) page: 27564-27573   2018.6

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    DOI: 10.18632/oncotarget.25548

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  60. Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation.

    Nishino K, Koda S, Kataoka N, Takamatsu S, Nakano M, Ikeda S, Kamamatsu Y, Morishita K, Moriwaki K, Eguchi H, Yamamoto E, Kikkawa F, Tomita Y, Kamada Y, Miyoshi E

    Oncotarget   Vol. 9 ( 16 ) page: 12732-12744   2018.2

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    DOI: 10.18632/oncotarget.24332

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  61. The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours.

    Kajiyama H, Suzuki S, Yoshihara M, Nishino K, Yoshikawa N, Utsumi F, Niimi K, Mizuno M, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Nagasaka T, Shibata K, Kikkawa F

    Oncotarget   Vol. 9 ( 5 ) page: 6298-6307   2018.1

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    DOI: 10.18632/oncotarget.23921

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  62. A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-beta derived from ovarian cancer

    Fujikake Kayo, Kajiyama Hiroaki, Yoshihara Masato, Nishino Kimihiro, Yoshikawa Nobuhisa, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Mitsui Hiroko, Shibata Kiyosumi, Senga Takeshi, Kikawa Fumitaka

    ONCOLOGY REPORTS   Vol. 39 ( 1 ) page: 193 - 200   2018.1

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    DOI: 10.3892/or.2017.6104

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  63. The role of N-acetylg lucosaminyltransferase IVa in choriocarcinoma progression

    Nishino Kimihiro, Yamamoto Eiko, Nakamura Kenichi, Niimi Kaoru, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 254-254   2018.1

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  64. ROLE OF GLYCOSYLTRANSFERASE C2GNT FOR THE EVASION MECHANISM OF NATURAL KILLER CELL IMMUNITY IN THE CHORIOCARCINOMA CELL

    Nakamura K., Niimi K., NIshino K., Yamamoto E., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1357-1357   2017.11

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  65. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

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    DOI: 10.3892/ijmm.2017.3067

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  66. Spontaneous regression of gestational trophoblastic neoplasia

    Niimi Kaoru, Yamamoto Eiko, Nishino Kimihiro, Fujiwara Sawako, Ino Kazuhiko, Kikkawa Fumitaka

    GYNECOLOGIC ONCOLOGY REPORTS   Vol. 21   page: 98 - 100   2017.8

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    DOI: 10.1016/j.gore.2017.07.011

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  67. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling

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    ONCOLOGY   Vol. 92 ( 5 ) page: 299 - 310   2017

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    DOI: 10.1159/000458529

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Books 1

  1. 産婦人科の実際 第70巻12号11月臨時増刊号 図解 分子メカニズムから理解する婦人科がんの薬物療法

    西野公博 新美薫 山本英子( Role: Joint author ,  絨毛性疾患)

    金原出版株式会社  2021.11 

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    Language:Japanese Book type:Scholarly book

KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. 在留外国人妊婦の不安・負荷・アンメットニーズを包括的に理解するための基盤研究

    Grant number:24K13287  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    西野 公博, 山本 英子

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    少子化が進む日本において、在留外国人妊婦による出生件数が近年増加しているが、在留外国人妊婦は妊娠、分娩にあたり、どのような点を不安や不満に思い、困難に感じ、それらがどのような負荷となって表れているのか、増加する在留外国人妊婦による出生に対して、医療従事者、医療施設、国(政府)や地方自治体などの医療行政機関は、在留外国人妊婦の不安やニーズに十分に対応できているのか、こうした問いに対して、本研究では、厚生労働省人口動態調査の調査票情報の利用や、医療施設、及び、在留外国人妊婦へのアンケート調査を通じて、答えやヒントとなるものを見出すことを目的として、研究を行う。

  2. Social implementation study of community comprehensive mental health care in maternal and child health policy

    Grant number:24K13288  2024.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  3. International collaborative study on risk factors of postpartum depression in Asian developing countries

    Grant number:23KK0169  2023.9 - 2029.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Authorship:Coinvestigator(s) 

  4. 新規標的蛋白LAMP-2による絨毛癌転移機構の解明

    Grant number:18K16764  2018.4 - 2021.3

    科学研究費助成事業  若手研究

    西野 公博

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  5. ホモシステインによるアポトーシスに着目した難治性絨毛癌に対する新規治療法の開発

    Grant number:21K16767  2021.4 - 2024.3

    科学研究費助成事業  若手研究

    西野 公博

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    難治性絨毛癌患者の予後を改善させるべく、絨毛癌に対する化学療法において中心的役割を果たすメトトレキサート(Methotrexate, MTX)に着目し、MTXの既知の抗腫瘍効果である葉酸代謝経路阻害とは別の、細胞内ホモシステイン濃度上昇作用に注目し、ホモシステインが絨毛癌細胞のアポトーシスを誘導することが考えられないかという仮説を立て、研究を実施する。
    ・MTX投与によるホモシステイン濃度の上昇についての検討
    1.絨毛癌細胞内ホモシステイン濃度の測定
    MTX投与により絨毛癌細胞内ホモシステイン濃度が上昇するか検討するため、絨毛癌細胞株Jar、BeWo、及び、JEG-3の培地にそれぞれ、PBS(コントロールとして用いる)とMTXを添加し、絨毛癌細胞内ホモシステイン濃度を測定を行った。それぞれの絨毛癌細胞を5000個播種し、24時間培養後、PBS、及び、1μMのMTXを添加し、48時間培養した後、細胞抽出液を回収した。細胞抽出液のホモシステイン濃度定量は、セルバイオラボ社のホモシステインELISAキットを用いた。結果は、いずれの絨毛癌細胞株においても、MTX添加により、絨毛癌細胞内ホモシステイン濃度の低下がみられ、予想に反するものであった。播種する絨毛癌細胞数、添加するMTX濃度、MTX添加時間など、様々な組み合わせで条件検討を試みたが、一定の傾向を示す結果は得られなかった。これらの要因として、MTX添加により死滅した絨毛癌細胞が細胞抽出液を回収する段階で除去されてしまうことが一因と考えられた。そこで、MTX投与後の絨毛癌細胞培養上清中ホモシステイン濃度の変化を検討するプランに変更した。
    2.絨毛癌細胞培養上清中ホモシステイン濃度の測定
    予備検討として、絨毛癌細胞培養上清中のホモシステイン濃度が正確に測定できるかまず検討することとした。24wellディッシュにJarを5000個播種し、オーバーナイトで培養した。培養上清を除去し、さらにオーバーナイトで培養した。このとき、培養上清は100μLとし、培養上清を全量回収た。回収した培養上清の原液、5倍希釈、10倍希釈したものを用意し、ホモシステイン濃度を測定したところ、希釈倍率に比例して、ホモステイン濃度の低下が認められ、絨毛癌細胞培養上清中のホモシステイン濃度が測定できることを確認した。
    絨毛癌細胞培養上清中のホモシステイン濃度の測定が可能であることは判明したが、実際にMTXを投与し、その濃度がどのように変化するのかはまだ検討できていないため、さらにMTXに対して耐性を示す絨毛癌細胞細胞株を使用した比較実験がまだ行えていないため。
    MTXを投与し、絨毛癌細胞培養上清中のホモシステイン濃度がどのように変化するのか検討する。MTXに対して耐性を示す絨毛癌細胞細胞株を使用し、この絨毛癌細胞細胞株がオリジナルの絨毛癌細胞細胞株とどのように異なる反応を示すか、すなわち、MTXを添加したときの培養上清中ホモステイン濃度がどのように変化するか検討する。