Faculty Profiles - NAKANISHI Keisuke

Papers - NAKANISHI Keisuke

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Exploring Indicators of Subcutaneous Tissue Fluid Accumulation in Breast Cancer-Related Lymphedema Patients Using Fractal Analysis with Virtual Volume Reviewed Open Access

Shiori Niwa, Fumiya Hisano, Ayana Mawaki, Keisuke Nakanishi, Sachiyo Watanabe, Atsushi Fukuyama, Toyone Kikumori, Kazuhiro Shimamoto, Kuniharu Imai, Etsuko Fujimoto, Chika Oshima

Lymphatic Research and Biology, Online ahead of print. Vol. 21 ( 5 ) page： 432 - 438 2023.5

A Pilot Study of Determining the Reliability of a New Three-Dimensional Scanning System for Measuring Truncal Thickness After Breast Cancer Surgery Reviewed International journal

Hisano Fumiya, Watanabe Sachiyo, Niwa Shiori, Nakanishi Keisuke, Mawaki Ayana, Takeno Yukari, Murota Kaoru, Honda Ikumi, Fujimoto Etsuko, Oshima Chika

LYMPHATIC RESEARCH AND BIOLOGY 2022.9

Prevalence of Metabolic Syndrome and Its Components in Urban Cambodia: A Cross-Sectional Study Reviewed Open Access

Miharu Tamaoki, Ikumi Honda, Keisuke Nakanishi, Sophathya Cheam, Manabu Okawada, Hisataka Sakakibara

Journal of Epidemiology and Global Health Vol. 12 ( 3 ) page： 224 - 231 2022.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

The incidence of noncommunicable diseases, such as cardiovascular diseases and diabetes mellitus, is increasing in Cambodia. Urbanization and lifestyle changes due to rapid economic development have affected the components of metabolic syndrome (MetS). This study aimed to determine the prevalence of MetS, MetS components, and health status among Cambodians living in urban areas.

Methods

This cross-sectional study enrolled adult Cambodians (age ≥ 20 years) who underwent a health checkup at a Japanese hospital in Phnom Penh. MetS was defined based on the harmonized diagnostic definition from the joint interim statement.

Results

Among the 6090 (3174 men and 2916 women) participants who were enrolled in the study, the prevalence of MetS was 60.1% in men and 52.4% in women. The prevalence of elevated blood pressure was 73.2% in men and 65.3% in women, and was the highest MetS component in both men and women. In contrast, the lowest prevalence rates were observed for abdominal obesity (44.8%) in men and for high triglyceride levels (33.5%) in women. The MetS group showed a significantly higher proportion of patients with hypertension, diabetes, dyslipidemia, and obesity compared with the non-MetS group.

Conclusion

The high prevalence of MetS in this study was attributed to urbanization, as in economically developed countries. It is necessary to explore the lifestyle habits of Cambodians that contribute to MetS and to develop preventive measures to reduce the incidence and prevalence of MetS.

DOI： 10.1007/s44197-022-00053-5

Other Link： https://link.springer.com/article/10.1007/s44197-022-00053-5/fulltext.html

Lifestyle Factors Associated with Metabolic Syndrome in Urban Cambodia Reviewed International coauthorship International journal Open Access

Miharu Tamaoki, Ikumi Honda, Keisuke Nakanishi, Maki Nakajima, Sophathya Cheam, Manabu Okawada, Hisataka Sakakibara

Int. J. Environ. Res. Public Health Vol. 19 ( 10481 ) page： 10481 - 10481 2022.8

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

This study aimed to identify lifestyle factors associated with metabolic syndrome (MetS) in urban Cambodia. In this cross-sectional study, we used existing health checkup data from a private hospital in Phnom Penh, Cambodia. The participants comprised 5459 Cambodians aged ≥20 years who underwent health checkups between 2017 and 2019. The harmonized diagnostic definition was used as the MetS criteria. The prevalence of MetS was 56.6% overall, 60.4% in men and 52.6% in women. The lifestyle factor significantly associated with MetS in both sexes were “eating quicker than others,” (men: odds ratio [OR]= 2.25, 95% confidence interval [CI] = 1.68–3.03, women: OR = 1.92, 95%CI = 1.41–2.60), “walking faster than others,” (men: OR = 0.78, 95% CI = 0.67–0.92, women: OR = 0.75, 95% CI = 0.62–0.89) and “drinking alcohol” (men: OR = 1.33, 95% CI = 1.10–1.61, women: OR = 1.33, 95% CI = 1.09–1.62). Other significant associations with MetS for men was “eating speed is normal,” (OR = 1.73, 95%CI = 1.30–2.31), and, for women, “eating food after dinner at least 3 days a week,” (OR = 1.25, 95%CI = 1.01–1.55), “skipping breakfast at least 3 days a week,” (OR = 0.83, 95%CI = 0.69–0.99) and “getting enough rest from sleep” (OR = 1.19, 95% CI = 1.01–1.42) were significantly associated with MetS. Lifestyle interventions through health education and guidance may be effective in preventing MetS in Cambodia.

DOI： 10.3390/ijerph191710481

An Educator's Growth as a Nursing Preceptor:A Modified Grounded Theory Approach Reviewed

H.Onbe, K.Nakanishi, C.Yamazaki, S Tanifuji, H Arai

The Kitakanto Medical Journal Vol. 72 ( 3 ) page： 263 - 270 2022.8

Abdominal Obesity and Related Lifestyle Factors Among Cambodians Living in Urban Areas: A Cross-sectional Study Reviewed International coauthorship International journal

Tamaoki, Miharu, Honda, Ikumi, Nakanishi, Keisuke, Takehara, Kimie, Doi, Tomoko, Cheam, Sophathya, Okawada, Manabu, Sakakibara, Hisataka

Asia-Pacific Academic Consortium for Public Health (APACPH) 2022

Nursing Practice for Discharge Support of Ward Nurses in Small and Medium-sized Hospitals Reviewed

Onbe Hiromi, Nakanishi Keisuke, Sanaki Isamu, Kobayashi Hiroko

Journal of Japan Academy of Home Care Vol. 26 ( 1 ) page： 83 - 92 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Academy of Home Care

The purpose of this study was to identify any challenges involved in the nursing practice being carried out by ward nurses in small and medium-sized hospitals in their discharge support work, in addition to clarifying the details of the work. Semi-structured interviews were conducted with 13 nurses working at small or medium-sized hospitals. Thereafter the data was qualitatively analyzed using an inductive approach. The content of the practice was: Working to improve motivation by leveraging the strengths of patients; Consideration for maintaining a good relationship between patients/family and the medical staff; Involvement that emphasizes the safety, maintenance, and feasibility of medical treatment behavior after discharge; Encourage patients/family to face reality and life after discharge; Finding compromises with patients/family regarding the life after discharge with functional deterioration; Coordinating points of agreement with patients/family while giving consideration to the circumstances of the hospital organization; Exercise leadership across multiple occupations by utilizing the expertise of nurses; and Team management to maintain and strengthen the support system for interdisciplinary approach. The nurses provided support of patient/family decision making and team management for inter-professionals. To promote discharge support by nurses working autonomously, it is important that a nursing manager evaluate and approve the ward nurses’ discharge support practice.

DOI： 10.60272/jjahc.26.1_83

CiNii Research

Prediction of the Presence of Fluid Accumulation in the Subcutaneous Tissue in BCRL Using Texture Analysis of Ultrasound Images Reviewed International journal

Shiori Niwa, Ayana Mawaki, Fumiya Hisano, Keisuke Nakanishi, Sachiyo Watanabe, Atsushi Fukuyama, Toyone Kikumori, Kazuhiro Shimamoto, Etsuko Fujimoto, Chika Oshima

Lymphatic Research and Biology Vol. 20 ( 1 ) page： 11 - 16 2021.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Mary Ann Liebert Inc

Background: Breast cancer-related lymphedema (BCRL) is a chronic swelling of the arm due to breast cancer treatment. Lymphedema is diagnosed and staged on the basis of limb circumference measurements and the patient's subjective symptoms, which have poor reproducibility and objectivity: these cannot detect any fluid accumulation in the tissue. Ultrasonography is a feasible noninvasive technique that can be used to evaluate tissue structure in real time. This study aimed to assess the ability of texture features for discriminating the presence of accumulated fluid within the subcutaneous tissue of BCRL using ultrasound (US) imaging. Methods and Results: This study included 20 women who were treated for unilateral breast cancer and who subsequently developed BCRL (International Society of Lymphology stage II). Subcutaneous tissue was scanned through an US system (Sonosite Edge II; Sonosite, Inc., FUJIFILM) using a 6- to 15-MHz linear transducer to assess the ability of texture features for discriminating the presence of accumulated fluid within the subcutaneous tissue of BCRL. Fluid accumulation was observed using a 3-Tesla MR system under double-echo steady-state conditions. There was a significant difference among the three groups (with hyperintense area, without hyperintense area, and unaffected side) in 11 of 14 textural features (p < 0.05). Post hoc analysis (Mann-Whitney U test; Bonferroni correction p < 0.0167) revealed significant differences in seven textural features within the hyperintense area. Conclusions: This study revealed that seven texture features quantified by US imaging data can provide information regarding fluid accumulation in the subcutaneous tissue of lymphedema.

DOI： 10.1089/lrb.2020.0121

Other Link： https://www.liebertpub.com/doi/pdf/10.1089/lrb.2020.0121

The Correlation Between Fluid Distribution and Swelling or Subjective Symptoms of the Trunk in Lymphedema Patients: A Preliminary Observational Study. Reviewed International journal Open Access

Fumiya Hisano, Shiori Niwa, Keisuke Nakanishi, Ayana Mawaki, Kaoru Murota, Atsushi Fukuyama, Yukari Takeno, Sachiyo Watanabe, Etsuko Fujimoto, Chika Oshima

Lymphatic research and biology Vol. 19 ( 3 ) page： 269 - 273 2020.11

Language：English Publishing type：Research paper (scientific journal)

Background:
Manual lymph drainage (MLD) is one of the common treatments for breast cancer-related lymphedema (BCRL). Although the primary goal of MLD is to drain the excessive fluid accumulated in the affected upper limb and trunk to an area of the body that drains usually, the use of MLD is decided based on swelling and subjective symptoms, without assessing whether there is fluid accumulated in the affected region. The purpose of this study was to examine truncal fluid distribution in a sample of BCRL patients and investigate any correlation between such fluid distribution and swelling or subjective symptoms.
Methods and Results:
An observational study was conducted with 13 women who had unilateral, upper extremity BCRL. Fluid distribution was evaluated by using two magnetic resonance imaging (MRI) sequences: half-Fourier acquisition single-shot turbo spin echo and three-dimensional double-echo steady-state. The presence of swelling was determined by lymphedema therapists, and subjective symptoms were measured by using a visual analog scale. On MRI, no participants had any free water signals in the trunk. However, seven had swelling and all 13 had some kind of subjective symptoms on the affected side of their trunk.
Conclusions:
These results suggest that swelling and subjective symptoms do not correlate with the presence of truncal fluid. For such cases, a different approach than MLD may be needed to address truncal swelling and related subjective symptoms. Checking for the presence of fluid in the truncal region may help MLD be used more appropriately.

File： The Correlation Between Fluid Distribution and Swelling or Subjective Symptoms of the Trunk in Lymphedema Patients.pdf

DOI： 10.1089/lrb.2020.0075

Nursing activities at clinics in rural areas in Japan: gaps between recognition of importance and implementation. Reviewed

Manami Tateishi, Keisuke Nakanishi, Kimie Takehara, Ikumi Honda, Toyoaki Yamauchi

Nagoya journal of medical science Vol. 82 ( 2 ) page： 251 - 260 2020.5

Language：English Publishing type：Research paper (scientific journal)

This study determined the level of implementation and the importance placed on various nursing activities at clinics in rural areas of Japan in order to explore the achievement and perceived importance of implementing certain nursing roles and activities at such clinics. To identify these items, a questionnaire was administered to 40 nurses working in rural clinics. The results showed that activities related to "Basic Nursing Practice" and "Community Understanding" were recognized as important and were performed by almost all nurses. Some activities related to "Administration and Operation" and "Cooperation with Local Government" were recognized as important, but were not implemented, thereby hampering the continuum of care across the health system. These activities, which are related to collaboration with hospitals and local governments that support the clinics, included adjustment of staff inside and outside the facilities to guarantee the use of paid holidays, as well as collaboration with acute care, remote medical systems, and local governments during emergencies and for disaster preparation. Additional support for nurses in collaboration between clinics in rural areas, hospitals, and regional administrations that support the clinics remains a challenge to be addressed.

File： Nursing activities at clinics in rural areas in Japan gaps between recognition of importance and implementation.pdf

DOI： 10.18999/nagjms.82.2.251

Breast Cancer-related Lymphedema with the presence or absence of accumulation of Fluid: MR Findings in ISL Stage II Cases (in printing) Reviewed

Shiori Niwa, Ayana Mawaki, Keisuke Nakanishi, Fumiya Hisano, Yukari Takeno, Atsushi Fukuyama, Toyone Kikumori, Kazuhiro Shimamoto, Etsuko Fujimoto, Chika Oshima

Structure and Function Vol. 18 ( 2 ) page： 88 - 94 2020.3

Factors associated with self-management in diabetic hemodialysis patient with non-sever visual impairment (in Japansese)

ONBE Hiromi, YAMAZAKI Chiho, NAKANISHI Keisuke, SHIMADA Mikiko, SANAKI Isamu

KIDNEY AND DIALYSIS Vol. 87 ( 2 ) page： 361 - 366 2019.8

Distribution of fluid in the upper limb with lymphedema: An analysis using magnetic resonance imaging Reviewed

Suzuki Yuiko, Mawaki Ayana, Nakanishi Keisuke, Kikumori Toyone, Takeno Yukari, Oshima Chika, Fujimoto Etsuko

Structure and Function Vol. 16 ( 2 ) page： 83-89 2018

Language：English Publishing type：Research paper (scientific journal)

The purpose of the present study was to evaluate the distribution patterns of fluid in the upper limbs of patients with breast-cancer-related lymphedema by using magnetic resonance images (MRI).Seven women (mean age ± SD: 55.9 ± 13.6 years) with unilateral breast cancer who subsequently developed lymphedema were recruited for this study. The status of lymphedema was evaluated using four MRI sequences, i.e., T1-weighted images, T2-weighted images without fat suppression, T2-weighted images with fat suppression (STIR), and conversion into fluid-attenuated inversion recovery (FLAIR) images. For the quantitative analysis of fluid, areas with hyper-intense signals on the STIR images were calculated for every transverse image slice.On STIR images, hyper-intense signals indicating the presence of free water were observed in the forearms, particularly in the ulnar half, of all patients. FLAIR images showed no hyperintense signals in this region. In the brachial region, five patients had such signals in the posterior arm(Regio brachii posterior). In the axillary region, no patients displayed hyper-intense signals. In the hands and fingers, the hyper-intense signals on STIR images were detected over the dorsal surface. Quantitative analysis indicated that a large amount of water accumulated in the ulnar half of the forearm.On the basis of these facts, we suggest that the ulnar half of the forearm should be an important target in lymph drainage therapy.

DOI： 10.11172/keitaikinou.16.83

LONG-TERM FOLLOW-UP OF COLLATERAL PATHWAYS ESTABLISHED AFTER LYMPHADENECTOMY IN RATS Reviewed

Y. Takeno, H. Arita, C. Oshima, A. Mawaki, K. Nakanishi, F. Kurono, E. Fujimoto

LYMPHOLOGY Vol. 50 ( 3 ) page： 131 - 135 2017.9

Language：English Publishing type：Research paper (scientific journal) Publisher：LYMPHOLOGY

A collateral pathway established after lymphadenectomy could play an important role in long-term lymphedema treatment. The present study investigated alterations of lymph dynamics 1 year after lymphadenectomy using indocyanine green fluorescent lymphography to determine if a collateral pathway may be used for long-term lymphedema treatment. Wistar rats were anaesthetized and lymph nodes were excised at the inguinal and popliteal fossae. The treated hind limb was evaluated by fluorescent lymphography between 10 weeks and 6 months and between 6 months and 1 year postoperatively. Fluorescent lymphography demonstrated a lymphatic pathway to the ipsilateral axillary fossa in all rats 1 year after lymphadenectomy. Some capillary branches in the paths leading to the ipsilateral axillary fossa were dilated and tortuous. In addition, areas in which a fluorescent signal was not visible were increased in the thigh. In conclusion, the collateral pathway did not appear to be only for temporary use to compensate for drainage from the edematous limb but appears more stable as a component of a compensating lymphatic system. These new dilated vessels, although functional at this point, may still be susceptible to disturbance by further alteration to the lymph vessels.

File： 131-135.Sep 2017_TAKENO.PDF

Web of Science

PubMed

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Nighttime Bandaging to Reduce Lymphedema Swelling A Clinical Pre-Post Study Reviewed

Nakanishi Keisuke, Mawaki Ayana, Oshima Chika, Takeno Yukari, Kurono Fumiya, Taniho Yuiko, Murotani Kenta, Kikumori Toyone, and Fujimoto Etsuko

SAGE Open Nursing Vol. 3 page： 1-8 2017

Importance of cystatin C and uric acid levels in the association of cardiometabolic risk factors in Japanese junior high school students. Reviewed

Harada M, Izawa A, Hidaka H, Nakanishi K, Terasawa F, Motoki H, Yazaki Y, Ikeda U, Hongo M, Study Project on Prevention of Metabolic Syndrome among Children,Adolescents,and Young Adults in Shinshu

Journal of cardiology page： - 2016.4

The Process of Living with Implantable Cardioverter Defibrillators among Middle-Aged Japanese Patients Reviewed

Keisuke Nakanishi, Michiyo Oka, Takeshi Tomita

Journal of Japan Academy of Nursing Science Vol. 34 ( 1 ) page： 311-320 2014

Serum High-density Lipoprotein Cholesterol Level and Lifestyle Habits among Japanese Junior High School Students Reviewed

Vol. 61 ( 4 ) page： 205-215 2013

Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students. Reviewed

Hongo M, Hidaka H, Sakaguchi S, Nakanishi K, Ichikawa M, Hirota N, Tanaka N, Tsuruta G, Yazaki Y, Kinoshita O, Ikeda U, Koike K, Investigators of Study Project on Prevention of Metabolic Syndrome among Children,Adolescents,and Young Adults in Shinshu

Circulation journal : official journal of the Japanese Circulation Society Vol. 74 page： 1570-1577 2010.8

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Papers - NAKANISHI Keisuke