研究者詳細 - 鬼頭　靖司

論文 - 鬼頭　靖司

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Fertilization and developmental competence of <i>in vitro</i> fertilized embryos from C57BL/6J mice of different ages and the impact of vitrification 査読有り国際誌

Kito, S

JOURNAL OF REPRODUCTION AND DEVELOPMENT 70 巻 ( 6 ) 頁： 405 - 410 2024年12月

Enhanced Effects of Chronic Restraint-Induced Psychological Stress on Total Body Fe-Irradiation-Induced Hematopoietic Toxicity in <i>Trp53</i>-Heterozygous Mice 査読有り国際誌

Wang, B; Katsube, T; Tanaka, K; Ninomiya, Y; Hirakawa, H; Liu, CH; Maruyama, K; Varès, G; Kito, S; Nakajima, T; Fujimori, A; Nenoi, M

LIFE-BASEL 12 巻 ( 4 ) 2022年4月

Synergistic Effects of Chronic Restraint-Induced Stress and Low-Dose 56Fe-particle Irradiation on Induction of Chromosomal Aberrations in Trp53-Heterozygous Mice. 査読有り国際誌

Katsube T, Wang B, Tanaka K, Ninomiya Y, Hirakawa H, Liu C, Maruyama K, Vares G, Liu Q, Kito S, Nakajima T, Fujimori A, Nenoi M

Radiation research 2021年4月

Detection of Alzheimer's disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein. 査読有り国際誌

Ji B, Ono M, Yamasaki T, Fujinaga M, Zhang MR, Seki C, Aoki I, Kito S, Sawada M, Suhara T, Sahara N, Higuchi M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 頁： 271678X21992457 2021年2月

Development of Human Sodium/Iodide Symporter (hNIS) Transgenic Mouse as Resource of Stem Cells for in vivo Cell Tracking 査読有り国際誌

Inubushi M., Michikawa Y., Kito S., Takeuchi Y., Kitagawa Y., Saga T.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 45 巻頁： S624 - S625 2018年10月

Functional analysis of lysosomes during mouse preimplantation embryo development 査読有り国際誌

Satoshi Tsukamoto, Taichi Hara, Atsushi Yamamoto, Yuki Ohta, Ayako Wada, Yuka Ishida, Seiji Kito, Tetsu Nishikawa, Naojiro Minami, Ken Sato, Toshiaki Kokubo

Journal of Reproduction and Development 59 巻 ( 1 ) 頁： 33 - 39 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）

Lysosomes are acidic and highly dynamic organelles that are essential for macromolecule degradation and many other cellular functions. However, little is known about lysosomal function during early embryogenesis. Here, we found that the number of lysosomes increased after fertilization. Lysosomes were abundant during mouse preimplantation development until the morula stage, but their numbers decreased slightly in blastocysts. Consistently, the protein expression level of mature cathepsins B and D was high from the one-cell to morula stages but low in the blastocyst stage. One-cell embryos injected with siRNAs targeted to both lysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) were developmentally arrested at the two-cell stage. Pharmacological inhibition of lysosomes also caused developmental retardation, resulting in accumulation of lipofuscin. Our fndings highlight the functional changes in lysosomes in mouse preimplantation embryos. © 2013 by the Society for Reproduction and Development.

Scopus

PubMed

Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons 査読有り

Barron AM, Higuchi M, Hattori S, Kito S, Suhara T, Ji B

Molecular neurobiology 58 巻 ( 2 ) 頁： 550 - 563 2021年2月

Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome 査読有り

Oka Yasuyoshi, Hamada Motoharu, Nakazawa Yuka, Muramatsu Hideki, Okuno Yusuke, Higasa Koichiro, Shimada Mayuko, Takeshima Honoka, Hanada Katsuhiro, Hirano Taichi, Kawakita Toshiro, Sakaguchi Hirotoshi, Ichimura Takuya, Ozono Shuichi, Yuge Kotaro, Watanabe Yoriko, Kotani Yuko, Yamane Mutsumi, Kasugai Yumiko, Tanaka Miyako, Suganami Takayoshi, Nakada Shinichiro, Mitsutake Norisato, Hara Yuichiro, Kato Kohji, Mizuno Seiji, Miyake Noriko, Kawai Yosuke, Tokunaga Katsushi, Nagasaki Masao, Kito Seiji, Isoyama Keiichi, Onodera Masafumi, Kaneko Hideo, Matsumoto Naomichi, Matsuda Fumihiko, Matsuo Keitaro, Takahashi Yoshiyuki, Mashimo Tomoji, Kojima Seiji, Ogi Tomoo

SCIENCE ADVANCES 6 巻 ( 51 ) 2020年12月

Effects of high calcium levels on the disturbed extrusion of the second polar body duringin vitrofertilization in C3H/He mouse substrains 査読有り

Ohta-Takada Y., Nagao Y., Kito S.

ZYGOTE 28 巻 ( 1 ) 頁： 83 - 85 2020年2月

Effects of high calcium levels on the disturbed extrusion of the second polar body during in vitro fertilization in C3H/He mouse substrains 査読有り

Y. Ohta-Takada, Y. Nagao and S. Kito

Zygote 2019年10月

Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male. 査読有り

Barron AM, Ji B, Kito S, Suhara T, Higuchi M.

Biochemical Journal 475 巻 ( 1 ) 頁： 75-85 2018年1月

Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors. 査読有り

Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M

The Journal of neuroscience : the official journal of the Society for Neuroscience 36 巻 ( 45 ) 頁： 11544-11558 2016年11月

Deficiencies in extrusion of the second polar body due to high calcium concentrations during in vitro fertilization in inbred C3H/He mice. 査読有り

Ohta Y, Nagao Y, Minami N, Tsukamoto S, Kito S.

Zygote. 24 巻 ( 4 ) 頁： 603-616 2016年8月

Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1-deficient mice. 査読有り

Morioka T, Miyoshi-Imamura T, Blyth BJ, Kaminishi M, Kokubo T, Nishimura M, Kito S, Tokairin Y, Tani S, Murakami-Murofushi K, Yoshimi N, Shimada Y, Kakinuma S

Cancer science 106 巻 ( 3 ) 頁： 217-26 2015年3月

Fluorescence-based visualization of autophagic activity predicts mouse embryo viability. 査読有り

Tsukamoto S, Hara T, Yamamoto A, Kito S, Minami N, Kubota T, Sato K, Kokubo T

Scientific reports 4 巻頁： 4533 2014年3月

Disruption of Aspm causes microcephaly with abnormal neuronal differentiation 査読有り

Fujimori A, Itoh K, Goto S, Hirakawa H, Wang B, Kokubo T, Kito S, Tsukamoto S, Fushiki S.

Brain and Development 36 巻 ( 8 ) 頁： 661-669 2013年11月

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice. 査読有り

Ishida M, Okazaki E, Tsukamoto S, Kimura K, Aizawa A, Kito S, Imai H, Minami N

PloS one 8 巻 ( 7 ) 頁： e68686 2013年

High osmolality vitrification: a new method for the simple and temperature-permissive cryopreservation of mouse embryos. 査読有り

Mochida K, Hasegawa A, Li MW, Fray MD, Kito S, Vallelunga JM, Lloyd KC, Yoshiki A, Obata Y, Ogura A

PloS one 8 巻 ( 1 ) 頁： e49316 2013年

Genomic and gene expression signatures of radiation in medulloblastomas after low-dose irradiation in Ptch1 heterozygous mice. 査読有り

Ishida Y, Takabatake T, Kakinuma S, Doi K, Yamauchi K, Kaminishi M, Kito S, Ohta Y, Amasaki Y, Moritake H, Kokubo T, Nishimura M, Nishikawa T, Hino O, Shimada Y

Carcinogenesis 31 巻 ( 9 ) 頁： 1694-701 2010年9月

Superovulatory response, oocyte spontaneous activation, and embryo development in WMN/Nrs inbred rats. 査読有り

Kito S, Yano H, Ohta Y, Tsukamoto S

Experimental animals 59 巻 ( 1 ) 頁： 35-45 2010年

In vitro fertilization in inbred BALB/c mice II: effects of lactate, osmolarity and calcium on in vitro capacitation. 査読有り

Kito S, Ohta Y

Zygote (Cambridge, England) 16 巻 ( 3 ) 頁： 259-70 2008年8月

In vitro fertilization in inbred BALB/c mice I: isotonic osmolarity and increased calcium-enhanced sperm penetration through the zona pellucida and male pronuclear formation. 査読有り

Kito S, Ohta Y

Zygote (Cambridge, England) 16 巻 ( 3 ) 頁： 249-57 2008年8月

Differential effects of low- and high-dose X-rays on N-ethyl-N-nitrosourea-induced mutagenesis in thymocytes of B6C3F1 gpt-delta mice. 査読有り

Yamauchi K, Kakinuma S, Sudo S, Kito S, Ohta Y, Nohmi T, Masumura K, Nishimura M, Shimada Y

Mutation research 640 巻 ( 1-2 ) 頁： 27-37 2008年4月

Developmental responses of 2-cell embryos to oxygen tension and bovine serum albumin in Wistar rats. 査読有り

Kito S, Kaneko Y, Yano H, Tateno S, Ohta Y

Experimental animals 57 巻 ( 2 ) 頁： 123-8 2008年4月

Medium effects on capacitation and sperm penetration through the zona pellucida in inbred BALB/c spermatozoa. 査読有り

Kito S, Ohta Y

Zygote (Cambridge, England) 13 巻 ( 2 ) 頁： 145-53 2005年5月

Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg. 査読有り

Shiomi N, Mori M, Kito S, Harada YN, Tanaka K, Shiomi T

DNA repair 4 巻 ( 3 ) 頁： 351-7 2005年3月

Improved in vitro fertilization and development by use of modified human tubal fluid and applicability of pronucleate embryos for cryopreservation by rapid freezing in inbred mice. 査読有り

Kito S, Hayao T, Noguchi-Kawasaki Y, Ohta Y, Hideki U, Tateno S

Comparative medicine 54 巻 ( 5 ) 頁： 564-70 2004年10月

Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. 査読有り

Shiomi N, Kito S, Oyama M, Matsunaga T, Harada YN, Ikawa M, Okabe M, Shiomi T.

Molecular and cellular Biology 24 巻 ( 9 ) 頁： 3712-9 2004年5月

Growth retardation and skin abnormalities of the Recql4-deficient mouse. 査読有り

Hoki Y, Araki R, Fujimori A, Ohhata T, Koseki H, Fukumura R, Nakamura M, Takahashi H, Noda Y, Kito S, Abe M

Human molecular genetics 12 巻 ( 18 ) 頁： 2293-9 2003年9月

Evaluation of developmental competence of vitrified-warmed early cleavage stage embryos and their application for chimeric mouse production. 査読有り

Kito S, Noguchi Y, Ohta Y, Ohhata T, Abe M, Shiomi N, Shiomi T.

Experimental Animals 52 巻 ( 2 ) 頁： 179-83 2003年3月

Developmental responses of two substrains of in vitro fertilized C57BL/6J mouse embryos to oxygen and amino acids. 査読有り

Kito S, Noguchi Y, Ohta Y

Experimental animals 52 巻 ( 1 ) 頁： 63-6 2003年1月

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