2023/07/19 更新

写真a

タケハラ ヤスオ
竹原 康雄
TAKEHARA Yasuo
所属
大学院医学系研究科 新規低侵襲画像診断法基盤開発研究寄附講座 特任教授
職名
特任教授

学位 1

  1. 博士(医学) ( 1994年12月   浜松医科大学 ) 

研究キーワード 6

  1. 造影剤

  2. 血流解析

  3. 胆膵疾患

  4. 磁気共鳴医学

  5. 画像診断

  6. Diagnostic Imaging

研究分野 1

  1. ライフサイエンス / 放射線科学

経歴 14

  1. 名古屋大学大学院医学系研究科新規低侵襲画像診断法基盤開発研究寄附講座教授

    2016年10月 - 現在

  2. 浜松医科大学医学部附属病院病院教授

    2011年1月

  3. 浜松医科大学附属病院放射線部助教授

    2001年10月

  4. - Associate professor and Vice-chairman of Radiology, Hamamatsu University Hospital

    2001年

  5. 浜松医科大学附属病院放射線科講師

    1995年7月

  6. 聖隷三方原病院放射線科医長、診療科長

    1991年4月

  7. 浜松医科大学

    1989年10月

  8. 米国カリフォルニア大学サンフランシスコ校 (UCSF)

    1988年7月

  9. Department of Radiology, MRI division, 客員研究員(国際ロータリー財団奨学金)

    1988年7月

  10. 社会福祉法人聖隷三方原病院放射線科 医員

    1987年4月

  11. 同 助手

    1986年7月

  12. 浜松医科大学附属病院放射線科医員

    1986年5月

  13. 浜松医科大学附属病院放射線科医員(研修医)

    1984年5月

  14. 浜松医科大学

    1984年4月

▼全件表示

所属学協会 12

  1. Radiological Society of North America

  2. International Society for Magnetic Resonance in Medicine

  3. 日本血管造形・インターベンショナルラジオロジー学会

  4. 日本膵臓学会

  5. 日本腹部放射線学会

  6. 日本脈管学会

  7. 日本胆道学会

  8. 日本磁気共鳴医学会

  9. 日本消化器病学会

  10. 日本核医学会

  11. 日本医学放射線学会

  12. 国際磁気共鳴医学会日本支部

▼全件表示

委員歴 12

  1. 日本医学放射線学会   造影剤安全性委員会委員  

    2022年3月   

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    団体区分:学協会

  2. 4D Flow研究会   代表世話人  

    2019年 - 現在   

  3. 国際磁気共鳴医学会日本支部支部長   ISMRM Japanese Chapter Chairperson  

    2018年 - 2019年   

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    団体区分:学協会

  4. 日本消化器画像診断研究会   世話人  

    2016年 - 現在   

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    団体区分:学協会

  5. Advanced Medical Imaging研究会(SAMI)   世話人  

    2016年 - 現在   

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    団体区分:学協会

  6. 日本医学放射線学会   学会誌Japanese Journal of Radiology編集委員  

    2002年 - 現在   

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    団体区分:学協会

  7. 日本放射線科医会・専門医会 理事  

    2002年 - 2020年   

  8. European Congress of Radiology, 学会誌European Radiology編集委員(欧州連合)  

    2002年   

  9. Editor of “Japanese Journal of Radiology” (official Journal of Japanese Radiological Society)  

  10. 日本磁気共鳴医学会   理事 学会誌Magnetic Resonance in Medical Sciences編集委員  

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    団体区分:学協会

  11. 日本腹部放射線学会   理事  

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    団体区分:学協会

  12. 日本医学放射線学会 代議員  

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受賞 1

  1. 優秀論文賞

    2021年9月   日本磁気共鳴医学会  

 

論文 48

  1. Iodinated Contrast Media Substitution to Prevent Recurrent Hypersensitivity Reactions: A Systematic Review and Meta-Analysis. 国際誌

    Umakoshi H, Nihashi T, Takada A, Hirasawa N, Ishihara S, Takehara Y, Naganawa S, Davenport MS, Terasawa T

    Radiology   305 巻 ( 2 ) 頁: 341 - 349   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1148/radiol.220370

    PubMed

  2. 4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications.

    Hyodo R, Takehara Y, Naganawa S

    La Radiologia medica   127 巻 ( 11 ) 頁: 1181 - 1198   2022年11月

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    記述言語:英語   出版者・発行元:Radiologia Medica  

    Thus far, ultrasound, CT, and 2D cine phase-contrast MRI has been adopted to evaluate blood flow and vascular morphology in the portal venous system; however, all these techniques have some shortcomings, such as limited field of view and difficulty in accurately evaluating blood flow. A new imaging technique, namely 3D cine phase-contrast (4D Flow) MRI, can acquire blood flow data of the entire abdomen at once and in a time-resolved manner, allowing visual, quantitative, and comprehensive assessment of blood flow in the portal venous system. In addition, a retrospective blood flow analysis, i.e., "retrospective flowmetry," is possible. Although the development of 4D Flow MRI for the portal system has been delayed compared to that for the arterial system owing to the lower flow velocity of the portal venous system and the presence of respiratory artifacts, several useful reports have recently been published as the technology has advanced. In the first part of this narrative review article, technical considerations of image acquisition and analysis methods of 4D Flow MRI for the portal venous system and the validations of their results are described. In the second part, the current clinical application of 4D Flow MRI for the portal venous system is reviewed.

    DOI: 10.1007/s11547-022-01553-x

    Scopus

    PubMed

  3. Four-dimensional flow magnetic resonance imaging visualizes reverse vortex pattern and energy loss increase in left bundle branch block. 査読有り 国際誌

    Miyajima K, Urushida T, Ito K, Kin F, Okazaki A, Takashima Y, Watanabe T, Kawaguchi Y, Wakabayashi Y, Takehara Y, Maekawa Y

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   24 巻 ( 8 ) 頁: 1284 - 1290   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology  

    AIMS: This study aimed to investigate the intraventricular blood flow pattern of patients with left bundle branch block (LBBB) using four-dimensional flow magnetic resonance imaging (4D-flow MRI). METHODS AND RESULTS: We performed 4D-flow MRI for 16 LBBB patients (LBBB group) and 16 propensity score-matched patients with a normal QRS duration (non-LBBB group). The energy loss (EL) in the left ventricle was evaluated. In both groups, blood flow from the mitral valve to the apex of the heart and left ventricular (LV) outflow tract during LV diastole were observed. Vortices were also observed in both groups. There were two patterns of vortices: unidirectional clockwise rotation and counterclockwise rotation taking place from the mid-diastole to the systole (reverse pattern). The reverse pattern was observed significantly more frequently in the LBBB group (LBBB 94% vs. non-LBBB 19%, P < 0.001). The interobserver agreement for the streamline analysis was good (kappa = 0.68). The maximum EL was significantly higher in the LBBB group [LBBB 12 (11-15) mW vs. non-LBBB 8.0 (6.2-9.7) mW, P < 0.001]. CONCLUSION: Left bundle branch block patients may suffer from inefficient LV haemodynamics reflected by non-physiological counterclockwise vortices and increased EL. Thus, the shape of the vortices and EL in the left ventricle can serve as markers of LV mechanical dyssynchrony in LBBB patients and could be investigated as predictors of response to cardiac resynchronization therapy.

    DOI: 10.1093/europace/euab299

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  4. Postendovascular Aneurysmal Repair Increase in Local Energy Loss for Fusiform Abdominal Aortic Aneurysm: Assessments With 4D flow MRI. 国際誌

    Horiguchi R, Takehara Y, Sugiyama M, Hyodo R, Komada T, Matsushima M, Naganawa S, Mizuno T, Sakurai Y, Sugimoto M, Banno H, Komori K, Itatani K

    Journal of magnetic resonance imaging : JMRI     2022年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Magnetic Resonance Imaging  

    Background: Although endovascular aneurysmal repair (EVAR) is a preferred treatment for abdominal aortic aneurysm (AAA) owing to its low invasiveness, its impact on the local hemodynamics has not been fully assessed. Purpose: To elucidate how EVAR affects the local hemodynamics in terms of energy loss (EL). Study Type: Prospective single-arm study. Field Strength/Sequence: A 3.0 T/4D flow MRI using a phase-contrast three-dimensional cine-gradient-echo sequence. Population: A total of 13 consecutive patients (median [interquartile range] age: 77.0 [73.0, 78.8] years, 11 male) scheduled for EVAR as an initial treatment for fusiform AAA. Assessment: 4D flow MRI covering the abdominal aorta and bilateral common iliac arteries and the corresponding stent-graft (SG) lumen was performed before and after EVAR. Plasma brain natriuretic peptide (BNP) was measured within 1 week before and 1 month after EVAR. The hemodynamic data, including mean velocity and the local EL, were compared pre-/post-EVAR. EL was correlated with AAA neck angle and with BNP. Patients were subdivided into deformed (N = 5) and undeformed SG subgroups (N = 8) and pre-/post-EVAR BNP compared in each. Statistics: Parametric or nonparametric methods. Spearman's rank correlation coefficients (r). The interobserver/intraobserver variabilities with Bland–Altman plots. A P value < 0.05 is considered significant. Results: The mean velocity (cm/sec) at the AAA was five times greater after EVAR: 4.79 ± 0.32 vs. 0.91 ± 0.02. The total EL (mW) increased by 1.7 times after EVAR: 0.487 (0.420, 0.706) vs. 0.292 (0.192, 0.420). The total EL was proportional to the AAA neck angle pre-EVAR (r = 0.691) and post-EVAR (r = 0.718). BNP (pg/mL) was proportional to the total EL post-EVAR (r = 0.773). In the deformed SG group, EL (0.349 [0.261, 0.416]) increased 2.4-fold to 0.848 (0.597, 1.13), and the BNP 90.3 (53.6, 105) to 100 (67.2, 123) post-EVAR. Conclusion: The local EL showed a 1.7-fold increase after EVAR. The larger increase in the EL in the deformed SG group might be a potential concern for frail patients. Evidence Level: 1. Technical Efficacy: Stage 2.

    DOI: 10.1002/jmri.28359

    Web of Science

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  5. Why 4D Flow MRI? Real Advantages.

    Takehara Y, Sekine T, Obata T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   21 巻 ( 2 ) 頁: 253 - 256   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    This special issue of Magnetic Resonance in Medical Sciences features the most recent reviews on 4D Flow MRI. These reviews deal with the current status of the emerging technique of 4D Flow MRI facilitated in various areas that are difficult to obtain with conventional flowmetry. MR signals inherently contain flow velocity information. In previous decades, in vivo blood flow measurement was traditionally performed by 2D methods, such as Doppler ultrasonography and 2D phase-contrast MRI, which have long been regarded as mature techniques in hemodynamic flowmetry. Although 2D velocimetries have many advantages over 4D Flow MRI in terms of cost and accessibility, and provide excellent temporal and in-plane spatial resolutions, they also have some disadvantages. The emerging technology of 4D Flow MRI can overcome the shortcomings of conventional 2D imaging. In recent years, hemodynamic analysis has witnessed significant progress that is primarily attributable to advances in 4D Flow MRI.

    DOI: 10.2463/mrms.e.2022-1000

    Web of Science

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  6. Clinical Application of 4D Flow MR Imaging for the Abdominal Aorta.

    Takehara Y

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   21 巻 ( 2 ) 頁: 354 - 364   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Blood vessels can be regarded as autonomous organs. The endothelial cells on the vessel surface serve as mechanosensors or mechanoreceptors for the flow velocity and turbulence of the blood flow in terms of wall shear stress (WSS), thereby monitoring changes in the flow velocity. Accordingly, the endothelial cells regulate the flow velocity by releasing numerous mediators. Such regulatory systems also trigger athero-sclerosis, where the WSS decreases or fluctuates to maintain the flow velocity or local WSS. As occurrences of abdominal aortic aneurysms and aortic dissection are closely related to atherosclerosis, understanding the hemodynamics of the abdominal aorta is necessary to obtain useful information concerning the pathogenesis, diagnosis, and interventions. 4D flow MRI is beneficial for measuring the hemodynamics through comprehensive retrospective flowmetry of the entire spatio-temporal distributions of the flow vectors. This section focuses on abdominal aortic aneurysms and aortic dissection as representative examples of abdominal aortic diseases. Their hemodynamic characteristics and how hemodynamics is involved in their progression are described, and how 4D flow MRI can contribute to their assessment is also explained.

    DOI: 10.2463/mrms.rev.2021-0156

    Web of Science

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  7. Does the Pulsatile Non-uniform Flow Matter in MR Flowmetry?

    Sugiyama M, Takehara Y, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   21 巻 ( 2 ) 頁: 365 - 371   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    3D cine phase-contrast (4D flow) MRI is a sequence with great potential for non-invasive time-resolved 3D flowmetry at arbitrary vessel sections in various blood vessels. However, it is not widely known that the flowmetry with 4D flow MRI is vulnerable to pulsatile and non-uniform flow. Due to the limited spatial and temporal resolutions, averaging within the 3D voxel is occurring during the flowmetry. A simple solution is to avoid setting the measurement plane in the area where non-uniform flow is dominant, which is possible with an aid of streamline depictions generated by computational fluid dynamics (CFD) or 4D flow MRI data. Unlike 4D flow MRI, flowmetry in CFD simulation can use higher spatial and temporal resolution depending on computer performance; therefore, it is robust to fluctuating non-uniform flow. However, the performance of CFD simulations might be limited due to inlet conditions with low temporal resolution. Difficulty applying complex blood flow such as reflection flow from periphery may also limit accurate simulation. Caution should be taken when comparing the result of CFD simulation to that of 4D flow measurement.

    DOI: 10.2463/mrms.rev.2021-0099

    Web of Science

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  8. Hemodynamic Parameters for Cardiovascular System in 4D Flow MRI: Mathematical Definition and Clinical Applications.

    Itatani K, Sekine T, Yamagishi M, Maeda Y, Higashitani N, Miyazaki S, Matsuda J, Takehara Y

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   21 巻 ( 2 ) 頁: 380 - 399   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Blood flow imaging becomes an emerging trend in cardiology with the recent progress in computer technology. It not only visualizes colorful flow velocity streamlines but also quantifies the mechanical stress on cardiovascular structures; thus, it can provide the detailed inspections of the pathophysiology of diseases and predict the prognosis of cardiovascular functions. Clinical applications include the comprehensive assessment of hemodynamics and cardiac functions in echocardiography vector flow mapping (VFM), 4D flow MRI, and surgical planning as a simulation medicine in computational fluid dynamics (CFD). For evaluation of the hemodynamics, novel mathematically derived parameters obtained using measured velocity distributions are essential. Among them, the traditional and typical parameters are wall shear stress (WSS) and its related parameters. These parameters indicate the mechanical damages to endothelial cells, resulting in degenerative intimal change in vascular diseases. Apart from WSS, there are abundant parameters that describe the strength of the vortical and/or helical flow patterns. For instance, vorticity, enstrophy, and circulation indicate the rotating flow strength or power of 2D vortical flows. In addition, helicity, which is defined as the cross-linking number of the vortex filaments, indicates the 3D helical flow strength and adequately describes the turbulent flow in the aortic root in cases with complicated anatomies. For the description of turbulence caused by the diseased flow, there exist two types of parameters based on completely different concepts, namely: energy loss (EL) and turbulent kinetic energy (TKE). EL is the dissipated energy with blood viscosity and evaluates the cardiac workload related to the prognosis of heart failure. TKE describes the fluctuation in kinetic energy during turbulence, which describes the severity of the diseases that cause jet flow. These parameters are based on intuitive and clear physiological concepts, and are suitable for in vivo flow measurements using inner velocity profiles.

    DOI: 10.2463/mrms.rev.2021-0097

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  9. Technical Background for 4D Flow MR Imaging.

    Terada M, Takehara Y, Isoda H, Wakayama T, Nozaki A

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   21 巻 ( 2 ) 頁: 267 - 277   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Recently, the hemodynamic assessments with 3D cine phase-contrast (PC) MRI (4D flow MRI) have attracted considerable attention from clinicians. Unlike 2D cine PC MRI, the technique allows for cardiac phase-resolved data acquisitions of flow velocity vectors within the entire FOV during a clinically viable period. Thus, the method has enabled retrospective flowmetry in the spatial and temporal axes, which are essential to derive hemodynamic parameters related to vascular homeostasis and those to the progression of the pathologies. Accelerations in imaging are critical for this technology to be clinically viable; however, a high SNR or velocity-to-noise ratio (VNR) is also vital for accurate flow measurements. In this chapter, the technologies enabling this difficult balance are discussed.

    DOI: 10.2463/mrms.rev.2021-0104

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  10. 特集 膵癌早期診断のイノベーションを求めて 早期膵癌のMRCP

    小川 浩, 竹原 康雄, 長縄 慎二

    画像診断   42 巻 ( 3 ) 頁: 271 - 278   2022年2月

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    出版者・発行元:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000002683

    CiNii Research

  11. 特集 膵癌早期診断のイノベーションを求めて 序説にかえて

    竹原 康雄, 蒲田 敏文

    画像診断   42 巻 ( 3 ) 頁: 247 - 251   2022年2月

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    出版者・発行元:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000002680

    CiNii Research

  12. Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI. 査読有り 国際誌

    de Boer A, Villa G, Bane O, Bock M, Cox EF, Dekkers IA, Eckerbom P, Fernández-Seara MA, Francis ST, Haddock B, Hall ME, Hall Barrientos P, Hermann I, Hockings PD, Lamb HJ, Laustsen C, Lim RP, Morris DM, Ringgaard S, Serai SD, Sharma K, Sourbron S, Takehara Y, Wentland AL, Wolf M, Zöllner FG, Nery F, Caroli A

    Journal of magnetic resonance imaging : JMRI   55 巻 ( 2 ) 頁: 323 - 335   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Magnetic Resonance Imaging  

    Background: Phase-contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood flow values across studies is large, most likely due to differences in PC-MRI acquisition and processing. Standardized acquisition and processing protocols are therefore needed to minimize this variability and maximize the potential of renal PC-MRI as a clinically useful tool. Purpose: To build technical recommendations for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and facilitate the comparability of results across scanners and in multicenter clinical studies. Study Type: Systematic consensus process using a modified Delphi method. Population: Not applicable. Sequence Field/Strength: Renal fast gradient echo-based 2D PC-MRI. Assessment: An international panel of 27 experts from Europe, the USA, Australia, and Japan with 6 (interquartile range 4–10) years of experience in 2D PC-MRI formulated consensus statements on renal 2D PC-MRI in two rounds of surveys. Starting from a recently published systematic review article, literature-based and data-driven statements regarding patient preparation, hardware, acquisition protocol, analysis steps, and data reporting were formulated. Statistical Tests: Consensus was defined as ≥75% unanimity in response, and a clear preference was defined as 60–74% agreement among the experts. Results: Among 60 statements, 57 (95%) achieved consensus after the second-round survey, while the remaining three showed a clear preference. Consensus statements resulted in specific recommendations for subject preparation, 2D renal PC-MRI data acquisition, processing, and reporting. Data Conclusion: These recommendations might promote a widespread adoption of renal PC-MRI, and may help foster the set-up of multicenter studies aimed at defining reference values and building larger and more definitive evidence, and will facilitate clinical translation of PC-MRI. Level of Evidence: 1. Technical Efficacy Stage: 1.

    DOI: 10.1002/jmri.27419

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  13. 腹部大動脈瘤成長予測のための内皮細胞整列モデルの構築

    伊藤 順平, 寺原 拓哉, 齋藤 耀玖, 吾妻 駿人, 石田 勝也, 滝沢 研二, Tezduyar Tayfun, 竹原 康雄

    バイオフロンティア講演会講演論文集   2022.32 巻 ( 0 ) 頁: 2C20   2022年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本機械学会  

    DOI: 10.1299/jsmebiofro.2022.32.2c20

    CiNii Research

  14. Assessing the Complicated Venous Hemodynamics and Therapeutic Outcomes of Budd-Chiari Syndrome with Respiratory-gated 4D Flow MR Imaging During the Expiratory and Inspiratory Phases. 査読有り

    Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Yokoyama S, Ishizu Y, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   advpub 巻 ( 0 )   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    DOI: 10.2463/mrms.ici.2021-0110

    PubMed

  15. Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright. 査読有り

    Takahashi M, Takehara Y, Fujisaki K, Okuaki T, Fukuma Y, Tooyama N, Ichijo K, Amano T, Goshima S, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   20 巻 ( 4 ) 頁: 359 - 370   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Purpose: Non-calcified cholesterol stones that are small in size are hard to be depicted on CT or magnetic resonance cholangiopancreatography. This institutional review board (IRB)-approved retrospective in vitro study aims to characterize contrast behaviors of 3 main components of the gallstones, i.e., cholesterol component (CC), bilirubin calcium component (BC) and CaCO3 (CO) on 3D radial scan with ultrashort TE (UTE) MRI, and to test the capability of depicting CC of gallstones as bright signals as compared to background saline. Methods: Fourteen representative gallstones from 14 patients, including 15 CC, 6 BC and 4 CO, were enrolled. The gallstones underwent MRI including fat-saturated T1-weighted image (fs-T1WI) and UTE MRI with dual echoes. The contrast-to-noise ratio (CNR) and the chemical analysis for the 25 portions of the stones were compared. Results: BC was bright on fs-T1WI, which did not change dramatically on UTE MRI and the signal did notremainonUTEsubtractionimagebetweendualechoes.WhereastheCCwasnegativeorfaintly positive signal on fs-T1WI, bright signal on UTE MRI and the contrast remained even higher on the UTE subtraction, which reflected their short T2 values. Median CNRs and standard errors of the segments on each imaging were as follows: on fs-T1WI, −10.2 ± 4.2 for CC, 149.7 ± 27.6 for BC and 37.9 ± 14.3 for CO; on UTE MRI first echo, 16.7 ± 3.3 for CC, 74.9 ± 21.3 for BC and 17.7 ± 8.4 for CO; on UTE subtraction image, 30.2 ±2.0 for CC, −11.2 ± 5.4 for BC and 17.8 ± 10.7 for CO. Linear correlations between CNRs and cholesterol concentrations were observed on fs-T1WI with r = −0.885, (P < 0.0001), UTE MRI first echo r = −0.524 (P = 0.0072) and UTE subtraction with r = 0.598 (P = 0.0016). Conclusion: UTE MRI and UTE subtraction can depict CC bright.

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  16. "Speckled Enhancement" on Gd-EOB-DTPA Enhanced MR Imaging of Primary Hepatic Mucosa-associated Lymphoid Tissue Lymphoma. 査読有り

    Hyodo R, Takehara Y, Nishida A, Matsushima M, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   advpub 巻 ( 0 )   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    DOI: 10.2463/mrms.mp.2021-0069

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  17. Imaging diagnosis of autoimmune pancreatitis: computed tomography and magnetic resonance imaging. 査読有り

    Ogawa H, Takehara Y, Naganawa S

    Journal of medical ultrasonics (2001)   48 巻 ( 4 ) 頁: 565 - 571   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Medical Ultrasonics  

    Autoimmune pancreatitis (AIP) is a pancreatic phenotype of IgG4-related systemic disease. Since its first description in the literature, characteristic imaging features have gradually become known to many clinicians encompassing various specialties in the past quarter century. CT and MRI have been the workhorses for imaging diagnosis of AIP. Typical features include sausage-like swelling of the focal or entire pancreas, duct-penetrating sign, a capsule-like rim of the affected lesions, and homogeneous delayed enhancement or enhanced duct sign after contrast administration, as well as characteristic combined findings reflecting coexisting pathologies in the other organs as a systemic disease. In this review, recent and future developments in CT and MRI that may help diagnose AIP are discussed, including restricted diffusion and perfusion and increased elasticity measured using MR.

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  18. Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting. 査読有り

    Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Ogura Y, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   20 巻 ( 3 ) 頁: 231 - 235   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    We present a case of a patient who underwent portal vein (PV) stenting for PV stenosis after a living-donor liver transplantation. A pretreatment 3D cine phase-contrast (4D-flow) MRI showed decreased, though hepatopetal, blood flow in the PV. After stenting, 4D-flow MRI confirmed an improvement in PV flow, with a more homogeneous flow distribution to each hepatic segment. 4D-flow MRI are valuable for under-standing the hemodynamics of this area, planning for treatments, and evaluating the outcome of the interventions.

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  19. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts

    Hyodo Ryota, Takehara Yasuo, Mizuno Takashi, Ichikawa Kazushige, Ishizu Yoji, Sugiyama Masataka, Naganawa Shinji

    HEPATOLOGY RESEARCH   51 巻 ( 3 ) 頁: 343 - 349   2021年3月

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    記述言語:日本語  

    DOI: 10.1111/hepr.13616

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  20. Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound. 査読有り 国際誌

    Suzuki K, Takehara Y, Sakata M, Kawate M, Ohishi N, Sugiyama K, Akai T, Suzuki Y, Sugiyama M, Kawamura T, Morita Y, Kikuchi H, Hiramatsu Y, Yamamoto M, Nasu H, Johnson K, Wieben O, Kurachi K, Takeuchi H

    PloS one   16 巻 ( 1 ) 頁: e0245878   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PLoS ONE  

    Respiratory-gated four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) is magnetic resonance (MR) imaging technique that enables analysis of vascular morphology and hemodynamics in a single examination using cardiac phase resolved 3D phase-contrast magnetic resonance imaging. The present study aimed to assess the usefulness of 4D PC-VIPR for the superior mesenteric artery (SMA) flowmetry before and after flow increase was induced by the herbal medicine Daikenchuto (TJ-100) by comparing it with Doppler ultrasound (DUS) as a current standard. Twenty healthy volunteers were enrolled in this prospective single-arm study. The peak cross-sectionally averaged velocity was measured by 4D PC-VIPR, peak velocity was measured by DUS, and flow volume (FV) of SMA and aorta were measured by 4D PC-VIPR and DUS 25 min before and after the peroral administration of TJ-100. The peak cross-sectionally averaged velocity, peak velocity, and FV of SMA measured by 4D PC-VIPR and DUS significantly increased after administration of TJ-100 (4D PC-VIPR: the peak cross-sectionally averaged velocity; p = 0.004, FV; p = 0.035, DUS: the peak velocity; p = 0.003, FV; p = 0.010). Furthermore, 4D PC-VIPR can analyze multiple blood vessels simultaneously. The ratio of the SMA FV to the aorta, before and after oral administration on the 4D PC-VIPR test also increased (p = 0.015). The rate of change assessed by 4D PC-VIPR and DUS were significantly correlated (the peak cross-sectionally averaged velocity and peak velocity: r = 0.650; p = 0.005, FV: r = 0.659; p = 0.004). Retrospective 4D PC-VIPR was a useful modality for morphological and hemodynamic analysis of SMA.

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  21. How Memory Switches Brain Responses of Patients with Post-traumatic Stress Disorder. 査読有り 国際誌

    Inoue J, Matsuo K, Iwabuchi T, Takehara Y, Yamasue H

    Cerebral cortex communications   2 巻 ( 2 ) 頁: tgab021   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/texcom/tgab021

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  22. Assessing the Risk of Intracranial Aneurysm Rupture Using Morphological and Hemodynamic Biomarkers Evaluated from Magnetic Resonance Fluid Dynamics and Computational Fluid Dynamics. 査読有り

    Perera R, Isoda H, Ishiguro K, Mizuno T, Takehara Y, Terada M, Tanoi C, Naito T, Sakahara H, Hiramatsu H, Namba H, Izumi T, Wakabayashi T, Kosugi T, Onishi Y, Alley M, Komori Y, Ikeda M, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   19 巻 ( 4 ) 頁: 333 - 344   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Purpose: Evaluate in vivo hemodynamic and morphological biomarkers of intracranial aneurysms, using magnetic resonance fluid dynamics (MRFD) and MR-based patient specific computational fluid dynamics (CFD) in order to assess the risk of rupture. Methods: Forty-eight intracranial aneurysms (10 ruptured, 38 unruptured) were scrutinized for six morphological and 10 hemodynamic biomarkers. Morphological biomarkers were calculated based on 3D time-of-flight magnetic resonance angiography (3D TOF MRA) in MRFD analysis. Hemodynamic biomarkers were assessed using both MRFD and CFD analyses. MRFD was performed using 3D TOF MRA and 3D cine phase-contrast magnetic resonance imaging (3D cine PC MRI). CFD was performed utilizing patient specific inflow–outflow boundary conditions derived from 3D cine PC MRI. Univariate analysis was carried out to identify statistically significant biomarkers for aneurysm rupture and receiver operating characteristic (ROC) analysis was performed for the significant biomarkers. Binary logistic regression was performed to identify independent predictive biomarkers. Results: Morphological biomarker analysis revealed that aneurysm size [P = 0.021], volume [P = 0.035] and size ratio [P = 0.039] were statistically significantly different between the two groups. In hemodynamic biomarker analysis, MRFD results indicated that ruptured aneurysms had higher oscillatory shear index (OSI) [OSI.max, P = 0.037] and higher relative residence time (RRT) [RRT.ave, P = 0.035] compared with unruptured aneurysms. Correspondingly CFD analysis demonstrated significant differences for both average and maximum OSI [OSI.ave, P = 0.008; OSI.max, P = 0.01] and maximum RRT [RRT.max, P = 0.045]. ROC analysis revealed AUC values greater than 0.7 for all significant biomarkers. Aneurysm volume [AUC, 0.718; 95% CI, 0.491–0.946] and average OSI obtained from CFD [AUC, 0.774; 95% CI, 0.586–0.961] were retained in the respective logistic regression models. Conclusion: Both morphological and hemodynamic biomarkers have significant influence on intracranial aneurysm rupture. Aneurysm size, volume, size ratio, OSI and RRT could be potential biomarkers to assess aneurysm rupture risk.

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  23. Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics. 査読有り

    Sugiyama M, Takehara Y, Kawate M, Ooishi N, Terada M, Isoda H, Sakahara H, Naganawa S, Johnson KM, Wieben O, Wakayama T, Nozaki A, Kabasawa H

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   19 巻 ( 4 ) 頁: 366 - 374   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Purpose: 2D cine phase contrast (PC)-MRI is a standard velocimetry for the superior mesenteric artery (SMA); however, the optimal localization of the measurement plane has never been fully discussed previ-ously. The purpose of this Institutional Review Board approved prospective and single arm study is to test whether flow velocimetry of the SMA with combined use of 2D cine PC-MRI and meal challenge is dependent on the localizations of the measurement planes and to seek optimal section for velocimetry. Methods: Seven healthy volunteers underwent cardiac phase resolved ECG gated 2D cine PC-MRI pre-and 30 min post-meal challenge at three measurement planes: proximal, curved mid section and distal straight section of the SMA at 3T. 4D Flow using 3D cine PC-MRI with vastly undersampled isotropic projection imaging (PC VIPR) was also performed right after 2D cine PC-MRI to delineate the flow dynamics within the SMA using streamline analysis. Two radiologists measured flow velocities, and rated the appearances of the abnormal flow in the SMA on streamlines derived from the 4D Flow and the computational fluid dynamics (CFD). Results: 2D cine PC-MRI measured increased temporally averaged flow velocity (mm/s) after the meal challenge only in the proximal (129.3 vs. 97.8, P = 0.0313) and distal section (166.9 vs. 96.2, P = 0.0313), not in the curved mid section (113.1 vs. 85.5, P = 0.0625). The average velocities were highest and their standard errors (8.5–26.5) were smallest at the distal straight section both before and after the meal challenge as compared with other sections. The streamline analysis depicted more frequent appearances of vertical or helical flow in the curved mid section both on 4D Flow and CFD (κ: 0.27–0.68). Conclusion: SMA velocimetry with 2D cine PC-MRI was dependent on the localization of the measurement planes. Distal straight section, not in the curved mid section is recommended for MR velocimetry.

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  24. 特集 画像診断に必要なartifactsの知識 MRIにおける注意すべきartifacts

    寺田 理希, 竹原 康雄

    臨床放射線   65 巻 ( 12 ) 頁: 1275 - 1294   2020年11月

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    出版者・発行元:金原出版  

    DOI: 10.18888/rp.0000001434

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  25. 4D Flow when and how? 査読有り 国際誌

    Takehara Y

    La Radiologia medica   125 巻 ( 9 ) 頁: 838 - 850   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Radiologia Medica  

    4D Flow is an emerging MR technique enabling three-dimensional and cardiac phase-resolved flowmetry with ECG-gated phase-contrast MRI that increased the speed of data acquisitions, accuracy and robustness. The method is promoting researches in areas that have not been fully addressed before in the cardiovascular system, such as flowmetry of the bloodstream across the valves, within the heart chambers, complexed flow dynamics such as vortex, helical or retrograde. Wall shear stress and other potential biomarkers derived from 4D Flow are known to be related to vascular wall diseases such as atherosclerosis. In this review, fundamental concepts of 4D Flow technique and post-processing, benefits and limitations as well as its clinical applications are discussed, and the importance of quality control and validation of the method is emphasized. New ideas inspired by 4D Flow can help clinicians and MR scientists further understand the role of flow dynamics in health sciences, diseases and various aspects of cardiovascular physiology.

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  26. Abnormal Flow Dynamics Result in Low Wall Shear Stress and High Oscillatory Shear Index in Abdominal Aortic Dilatation: Initial in vivo Assessment with 4D-flow MRI. 査読有り

    Takehara Y, Isoda H, Takahashi M, Unno N, Shiiya N, Ushio T, Goshima S, Naganawa S, Alley M, Wakayama T, Nozaki A

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   19 巻 ( 3 ) 頁: 235 - 246   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Purpose: To characterize the non-laminar flow dynamics and resultant decreased wall shear stress (WSS) and high oscillatory shear index (OSI) of the infrarenal abdominal aortic dilatation, cardiac phase-resolved 3D phase-contrast MRI (4D-flow MRI) was performed. Methods: The prospective single-arm study was approved by the Institutional Review Board and included 18 subjects (median 67.5 years) with the dilated infrarenal aorta (median diameter 35 mm). 4D-flow MRI was con-ducted on a 1.5T MRI system. On 3D streamline images, laminar and non-laminar (i.e., vortex or helical) flow patterns were visually assessed both for the dilated aorta and for the undilated upstream aorta. Cardiac phase-resolved flow velocities, WSS and OSI, were also measured for the dilated aorta and the upstream undilated aorta. Results: Non-laminar flow represented by vortex or helical flow was more frequent and overt in the dilated aorta than in the undilated upstream aorta (P < 0.0156) with a very good interobserver agreement (weighted kappa: 0.82–1.0). The WSS was lower, and the OSI was higher on the dilated aortic wall compared with the proximal undilated segments. In mid-systole, mean spatially-averaged WSS was 0.20 ± 0.016 Pa for the dilated aorta vs. 0.68 ± 0.071 Pa for undilated upstream aorta (P < 0.0001), and OSI on the dilated aortic wall was 0.093 ± 0.010 vs. 0.041 ± 0.0089 (P = 0.013). The maximum values and the amplitudes of the WSS at the dilated aorta were inversely proportional to the ratio of dilated/undilated aortic diameter (r = −0.694, P = 0.0014). Conclusion: 4D-flow can characterize abnormal non-laminar flow dynamics within the dilated aorta in vivo. The wall of the infrarenal aortic dilatation is continuously and increasingly affected by atherogenic stimuli due to the flow disturbances represented by vortex or helical flow, which is reflected by lower WSS and higher OSI.

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  27. Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer. 査読有り 国際誌

    Karayama M, Yoshizawa N, Sugiyama M, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Goshima S, Suda T, Takehara Y

    Lung cancer (Amsterdam, Netherlands)   143 巻   頁: 47 - 54   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Lung Cancer  

    Objectives: Conventional evaluation of anti-tumor activity on the basis of tumor size is inadequate for immune checkpoint inhibitors (ICIs). We therefore aimed to assess the usefulness of intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) for evaluation of the therapeutic efficacy of ICIs. Materials and methods: A chest IVIM-MRI was performed before and 2, 4, and 8 weeks after administration of ICIs in patients with advanced non-small-cell lung cancer. Apparent diffusion coefficient (ADC), skewness of ADC (ADCskew), kurtosis of ADC (ADCkurt), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were evaluated at each evaluation point and changes from the baseline (Δ). Results: Twenty patients were enrolled in this study. An increased ADC 8 weeks and decreased ADCkurt and ΔADCkurt 4 weeks after ICIs was associated with objective responses and longer progression-free survival (PFS). A decreased ΔADCskew at 4 weeks was associated with objective responses, disease control, and longer PFS and overall survival. There was no correlation between the efficacy of ICIs and D, D* and f. All of three patients who had pseudoprogression had decreased ΔADCskew at 4 weeks and two of them had decreased ΔADCkurt at 4 weeks. Inversely, all five patients who had progressive disease (PD) did not have increased ΔADCskew at 4 weeks and only one of them had decreased ΔADCkurt at 4 weeks. Conclusions: Changes in histograms of ADC may be useful for predicting long-term efficacy and distinguishing between pseudoprogression and actual PD after ICIs.

    DOI: 10.1016/j.lungcan.2020.03.013

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  28. Pharmacologic and non-pharmacologic interventions to prevent hypersensitivity reactions of non-ionic iodinated contrast media: a systematic review protocol.

    Umakoshi H, Nihashi T, Shimamoto H, Yamada T, Ishiguchi H, Takada A, Hirasawa N, Ishihara S, Takehara Y, Naganawa S, Davenport M, Terasawa T

    BMJ open   10 巻 ( 3 ) 頁: e033023   2020年3月

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    記述言語:英語   出版者・発行元:BMJ Open  

    Introduction: Iodinated contrast media are commonly used in medical imaging and can cause hypersensitivity reactions, including rare but severe life-threatening reactions. Although several prophylactic approaches have been proposed for severe reactions, their effects remain unclear. Therefore, we aim to review systematically the preventive effects of pharmacologic and non-pharmacologic interventions and predictors of acute, hypersensitivity reactions. Methods and analysis: We will search the PubMed, EMBASE and Cochrane Central Register of Controlled Trials databases from 1 January 1990 through 31 December 2019 and will examine the bibliographies of eligible studies, pertinent review articles and clinical practice guidelines. We will include prospective and retrospective studies of any design that evaluated the effects of pharmacological and non-pharmacological preventive interventions for adverse reactions of non-ionic iodinated contrast media. Two assessors will independently extract the characteristics of the study and intervention and the quantitative results. Two independent reviewers will assess the risk of bias using standard design-specific validity assessment tools. The primary outcome will be reduction in acute contrast media-induced hypersensitivity reactions. The secondary outcomes will include characteristics associated with the development of contrast media-induced acute hypersensitivity reactions, and adverse events associated with specific preventive interventions. Unique premedication regimens (eg, dose, drug and duration) and non-pharmacological strategies will be analysed separately. Average-risk and high-risk patients will be considered separately. A meta-analysis will be performed if appropriate. Ethics and dissemination: Ethics approval is not applicable, as this will be a secondary analysis of publicly available data. The results of the analysis will be submitted for publication in a peer reviewed journal. PROSPERO registration number CRD42019134003.

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  29. Motion and solution in hepatobiliary agent-enhanced dynamic MRI: solid evidence and unanswered question.

    Motosugi U, Takehara Y

    Japanese journal of radiology   38 巻 ( 2 ) 頁: 99 - 100   2020年2月

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    記述言語:英語   出版者・発行元:Japanese Journal of Radiology  

    DOI: 10.1007/s11604-019-00900-9

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  30. 特集 MRIで読み解く 心臓と脈管:流れと機能 腹部大動脈瘤の4D–flow

    杉山 将隆, 竹原 康雄

    臨床画像   36 巻 ( 1 ) 頁: 42 - 48   2020年1月

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    出版者・発行元:メジカルビュー社  

    DOI: 10.18885/ci.0000000106

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  31. Accuracy of the Flow Velocity and Three-directional Velocity Profile Measured with Three-dimensional Cine Phase-contrast MR Imaging: Verification on Scanners from Different Manufacturers. 査読有り

    Watanabe T, Isoda H, Fukuyama A, Takahashi M, Amano T, Takehara Y, Oishi N, Kawate M, Terada M, Kosugi T, Komori Y, Fukuma Y, Alley M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   18 巻 ( 4 ) 頁: 265 - 271   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本磁気共鳴医学会  

    Purpose: The accuracy of flow velocity and three-directional velocity components are important for the precise visualization of hemodynamics by 3D cine phase-contrast MRI (3D cine PC MRI, also referred to as 4D-flow). The aim of this study was to verify the accuracy of these measurements of prototype or commercially available 3D cine PC MRI obtained by three different manufactures’ MR scanners. Methods: The verification of the accuracy of flow velocity in 3D cine PC MRI was performed by circulating blood mimicking fluid through a straight-tube phantom in a slanting position, such that the three-directional velocity components were simultaneously measurable, using three 3T MR scanners from different manufacturers. The data obtained were processed by phase correction, and the velocity and three-directional velocity components in the center of the tube on the central cross section of a slab were calculated. The velocity profile in each three directions and the composite velocity profiles were compared with the calculated reference values, using the Hagen–Poiseuille equation. In addition, velocity profiles and the spatially time-averaged velocity perpendicular to the tube were compared with the theoretical values and measured values by a flowmeter, respectively. Results: An underestimation of the maximum velocity in the center of the tube and an overestimation of the velocity near the tube wall due to partial volume effects were observed in all three scanners. A roughening and flattening of profiles in the center of the tube were observed in one scanner, due, presumably, to the low signal-to-noise ratio. However, the spatially time-averaged velocities corresponded well with the measured values by the flowmeter in all three scanners. Conclusion: In this study, we have demonstrated that the accuracy of flow velocity and three-directional velocity components in 3D cine PC MRI was satisfactory in all three MR scanners.

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  32. Mechanical haemolytic anaemia assessed with four-dimensional flow cardiac magnetic resonance. 査読有り 国際誌

    Uchida W, Tokuda Y, Takehara Y, Usui A

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   56 巻 ( 4 ) 頁: 813 - 814   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:European Journal of Cardio-thoracic Surgery  

    A 66-year-old woman developed marked haemolytic anaemia 2 years after total aortic arch replacement using a branched Dacron graft. Echocardiography confirmed bicuspid aortic valve stenosis. A four-dimensional flow magnetic resonance imaging revealed a jet flow arising from the aortic valve along with the vortex and turbulent flow inside the kinked prosthetic graft at the ascending aorta. She underwent a reoperation to replace the aortic valve and correct the kinking. The estimated energy loss after intervention was relieved to 2.9 mJ/cardiac cycle from 4.3 mJ/cardiac cycle before intervention. The patient's anaemia resolved immediately after the reoperation.

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  33. Flow dynamics of type II endoleaks can determine sac expansion after endovascular aneurysm repair using four-dimensional flow-sensitive magnetic resonance imaging analysis. 査読有り 国際誌

    Katahashi K, Sano M, Takehara Y, Inuzuka K, Sugiyama M, Alley MT, Takeuchi H, Unno N

    Journal of vascular surgery   70 巻 ( 1 ) 頁: 107 - 116.e1   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Vascular Surgery  

    Objective: The objective of this study was to investigate the hemodynamic parameters of type II endoleaks (T2ELs) to predict sac expansion using four-dimensional flow-sensitive magnetic resonance imaging (4D-flow MRI) analysis. Methods: Patients who underwent endovascular aneurysm repair (EVAR) and were diagnosed with a T2EL were included in the study. Using 4D-flow MRI at 7 days, the peak flow velocity and amplitude of dynamics of blood flow per minute were measured in each T2EL vessel. The peak flow velocity was defined as the maximum of the absolute value of the blood flow velocity. The amplitude of dynamics of blood flow in the tributary arteries was defined as the sum of the absolute values of the inflow and outflow volume in each vessel. The amplitude of dynamics of blood flow in the tributary arteries per sac was calculated in each sac. The aneurysm sac diameter was measured by computed tomography (CT) at 1 year. The patients were divided into two groups according to the presence or absence of sac expansion. Results: Of 155 patients who underwent EVAR, both CT angiography and 4D-flow MRI were performed in 107 patients at 7 days after EVAR. Among them, 39 (36.4%) were found to have a T2EL, of whom 28 were re-evaluated with CT angiography and 4D-flow at 1 year; 7 patients had expanding sacs (expanding group), whereas 21 had nonexpanding sacs (not-expanding group). At 7 days, 28 patients had 80 T2EL vessels detected by 4D-flow MRI, of which 39 vessels (48.8%) had stopped flowing at 1 year (transient vessels); 41 vessels (51.3%) had sustained flow (persistent vessels). The persistent vessels had significantly larger peak flow velocity and amplitude of dynamics of blood flow. The comprehensive analysis of T2EL vessels per sac identified that the amplitude of dynamics of blood flow in the tributary arteries per sac was significantly higher in the expanding group than in the not-expanding group. A receiver operating characteristic curve analysis revealed that the sensitivity and specificity of sac enlargement at a cutoff value of 3750 mm3/min were 85.7% and 76.2%, respectively. Conclusions: The fate of aneurysm sacs with T2ELs after EVAR has remained difficult to predict. A comprehensive analysis of concurrent multiple T2EL vessels using 4D-flow MRI analysis may enable prediction of the sac expansion after EVAR.

    DOI: 10.1016/j.jvs.2018.09.048

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  34. A case of human pancreatic eurytremiasis. 国際誌

    Ogawa H, Takehara Y, Naganawa S, Yamaguchi J, Nakaguro M

    Abdominal radiology (New York)   44 巻 ( 4 ) 頁: 1213 - 1216   2019年4月

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    記述言語:英語   出版者・発行元:Abdominal Radiology  

    This study provides the first comprehensive imaging report of human pancreatic eurytremiasis. A 43-year-old man with obstructive jaundice and a pancreatic tumor was referred for diagnosis and treatment. Serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were elevated. Computed tomography (CT) revealed a multilocular cystic lesion with delayed enhanced area in the pancreas head. On magnetic resonance imaging, the tumor was hyperintense on diffusion-weighted image, and the apparent diffusion coefficient value of the tumor was lower than that of the normal pancreatic parenchyma. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-d-glucose integrated with computed tomography ( 18 F-FDG PET/CT) revealed abnormally increased uptake of 18 F-FDG in the tumor. A subtotal stomach-preserving pancreaticoduodenectomy was performed on the preoperative diagnosis of pancreatic carcinoma accompanied by branch duct-type intraductal papillary mucinous neoplasm. Multifocal granulomatous lesions with necrotic areas including many parasite eggs were seen on the histology. The final diagnosis was pancreatic eurytremiasis.

    DOI: 10.1007/s00261-019-01925-4

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  35. 特集 全身拡散強調画像の歴史と発展 全身拡散強調画像の歴史と発展-序文にかえて

    竹原 康雄

    臨床放射線   64 巻 ( 3 ) 頁: 213 - 214   2019年3月

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    出版者・発行元:金原出版  

    DOI: 10.18888/rp.0000000775

    CiNii Research

  36. 膵癌update Ⅱ 診断 ⑥MRI/MRCP

    小川 浩, 竹原 康雄, 長縄 慎二

    臨床消化器内科   33 巻 ( 7 ) 頁: 789 - 793   2018年5月

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    出版者・発行元:日本メディカルセンター  

    DOI: 10.19020/cg.0000000391

    CiNii Research

  37. Hemodynamic vascular biomarkers for initiation of paraclinoid internal carotid artery aneurysms using patient-specific computational fluid dynamic simulation based on magnetic resonance imaging. 国際誌

    Watanabe T, Isoda H, Takehara Y, Terada M, Naito T, Kosugi T, Onishi Y, Tanoi C, Izumi T

    Neuroradiology   60 巻 ( 5 ) 頁: 545 - 555   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neuroradiology  

    Purpose: We performed computational fluid dynamics (CFD) for patients with and without paraclinoid internal carotid artery (ICA) aneurysms to evaluate the distribution of vascular biomarkers at the aneurysm initiation sites of the paraclinoid ICA. Methods: This study included 35 patients who were followed up for aneurysms using 3D time of flight (TOF) magnetic resonance angiography (MRA) and 3D cine phase-contrast MR imaging. Fifteen affected ICAs were included in group A with the 15 unaffected contralateral ICAs in group B. Thirty-three out of 40 paraclinoid ICAs free of aneurysms and arteriosclerotic lesions were included in group C. We deleted the aneurysms in group A based on the 3D TOF MRA dataset. We performed CFD based on MR data set and obtained wall shear stress (WSS), its derivatives, and streamlines. We qualitatively evaluated their distributions at and near the intracranial aneurysm initiation site among three groups. We also calculated and compared the normalized highest (nh-) WSS and nh-spatial WSS gradient (SWSSG) around the paraclinoid ICA among three groups. Results: High WSS and SWSSG distribution were observed at and near the aneurysm initiation site in group A. High WSS and SWSSG were also observed at similar locations in group B and group C. However, nh-WSS and nh-SWSSG were significantly higher in group A than in group C, and nh-SWSSG was significantly higher in group A than in group B. Conclusion: Our findings indicated that nh-WSS and nh-SWSSG were good biomarkers for aneurysm initiation in the paraclinoid ICA.

    DOI: 10.1007/s00234-018-2002-8

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  38. 【大動脈疾患の画像診断:画像所見・画像からみた自然史・治療効果判定】 大動脈疾患のMRI. 査読有り

    竹原 康雄

    臨床画像   34 巻 ( 1 ) 頁: 40-52   2018年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  39. Four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) MR evaluation of the renal arteries in transplant recipients: Preliminary results. 査読有り 国際誌

    Motoyama D, Ishii Y, Takehara Y, Sugiyama M, Yang W, Nasu H, Ushio T, Hirose Y, Ohishi N, Wakayama T, Kabasawa H, Johnson K, Wieben O, Sakahara H, Ozono S

    Journal of magnetic resonance imaging : JMRI   46 巻 ( 2 ) 頁: 595 - 603   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Magnetic Resonance Imaging  

    Purpose: To assess the performance of four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) at 3.0T in depicting intrarenal arteries compared with computed tomography angiography (CTA), and its correlation with arterial flowmetry in comparison with Doppler ultrasonography (DUS). Materials and Methods: In our prospective single-arm study, subjects were 25 patients who underwent renal transplant-related surgery at our hospital between July 2011 and June 2015. In the morphological study, depictions of renal artery branches delineated by magnetic resonance angiography (MRA)/4D PC-VIPR without gadolinium contrast agent were compared in seven living transplant recipients with the same kidney delineated by CTA in seven living transplant donors. In the flowmetric study, flow velocities in the renal (main stem), segmental, and interlobar arteries during systole and diastole were measured in 12 recipients using noncontrast MRA/4D PC-VIPR, and were compared with those obtained from DUS. Results: Concerning MRA, average confidence levels of delineation rated by six observers for secondary to third level renal artery branches were 82.9–100% and for the fourth to fifth branches were 60.8–89.7% (average kappa value of 0.588 [95% confidence interval: 0.522–0.653]). Total flow velocities measured using 4D PC-VIPR and DUS demonstrated significant correlations during both systole and diastole with acceptable bias (r = 0.902; P < 0.001 in systole and r = 0.734; P < 0.001 in diastole). Conclusion: 4D PC-VIPR was useful in generating both morphological and hemodynamic information for evaluation of transplant intrarenal arteries without the need for contrast media. Level of Evidence: 2. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:595–603.

    DOI: 10.1002/jmri.25607

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  40. Validation of numerical simulation methods in aortic arch using 4D Flow MRI. 査読有り

    Miyazaki S, Itatani K, Furusawa T, Nishino T, Sugiyama M, Takehara Y, Yasukochi S

    Heart and vessels   32 巻 ( 8 ) 頁: 1032 - 1044   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00380-017-0979-2

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    PubMed

  41. Characterizing saccular aortic arch aneurysms from the geometry-flow dynamics relationship.

    Natsume K, Shiiya N, Takehara Y, Sugiyama M, Satoh H, Yamashita K, Washiyama N.

    J Thorac Cardiovasc Surg.   153 巻 ( 6 ) 頁: 1413-1420   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  42. Characterizing saccular aortic arch aneurysms from the geometry-flow dynamics relationship. 査読有り 国際誌

    Natsume K, Shiiya N, Takehara Y, Sugiyama M, Satoh H, Yamashita K, Washiyama N

    The Journal of thoracic and cardiovascular surgery   153 巻 ( 6 ) 頁: 1413 - 1420.e1   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jtcvs.2016.11.032

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  43. すとらびすむす 神の創造

    竹原 康雄

    画像診断   37 巻 ( 7 ) 頁: 621 - 621   2017年5月

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    出版者・発行元:学研メディカル秀潤社  

    DOI: 10.15105/gzj.0000003167

    CiNii Research

  44. 【最新分類に基づく画像による悪性腫瘍の病期診断2017】 膵癌. 査読有り

    牛尾 貴輔, 阪原 晴海, 竹原 康雄

    臨床画像   33 巻 ( 4月増刊 ) 頁: 140-8   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  45. 【圧縮センシングの旅-MRI高速化を探る-】 圧縮センシング(Cs)の現状 臨床MRIの知見と有用性. 査読有り

    寺田 理希, 松芳 圭吾, 小板橋 実夏, 安澤 千奈, 大杉 正典, 内藤 眞明, 沓掛 康道, 岩倉 岳史, 山中 典子, 吉原 和代, 吉原 修, 礒田 治夫, 竹原 康雄

    Rad Fan   15 巻 ( 15 ) 頁: 43-7   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  46. 【局所進行膵癌の治療限界に挑む】 局所進行膵癌の術前治療後の画像診断. 査読有り

    小川 浩, 鈴木 耕次郎, 竹原 康雄, 長縄 慎二

    胆と膵   38 巻 ( 11 ) 頁: 1255-60   2017年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  47. Validation of numerical simulation methods in aortic arch using 4D Flow MRI. 査読有り

    Miyazaki S, Itatani K, Furusawa T, Nishino T, Sugiyama M, Takehara Y, Yasukochi S.

    Heart Vessels.   32 巻 ( 8 ) 頁: 1032-1044   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  48. Intra-left ventricular flow dynamics in patients with preserved and impaired left ventricular function: Analysis with 3D cine phase contrast MRI (4D-Flow). 査読有り

    Suwa K, Saitoh T, Takehara Y, Sano M, Saotome M, Urushida T, Katoh H, Satoh H, Sugiyama M, Wakayama T, Alley M, Sakahara H, Hayashi H.

    J Magn Reson Imaging.   44 巻 ( 6 ) 頁: 1493-1503   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物 1

  1. シンプル薬理学

    野村 隆英, 石川 直久, 梅村 和夫, 天ヶ瀬 紀久子, 野元 正弘, 岡田 尚志郎, 植田 真一郎, 近藤 一直, 松野 浩之, 西尾 眞友, 三鴨 廣繁, 丹羽 雅之, 竹原 康雄, 新井 信

    南江堂  2020年  ( ISBN:9784524246588

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    記述言語:日本語

    CiNii Books

MISC 31

  1. A case of intraductal tubulopapillary neoplasm of the pancreas originating from the branch duct: cast in the mold sign

    Horiguchi R, Ogawa H, Nagai N, Takehara Y, Naganawa S, Yokoyama Y, Shimoyama Y  

    Nagoya journal of medical science83 巻 ( 4 ) 頁: 869 - 875   2021年11月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    A 59-year-old man with jaundice and lower common bile duct stenosis was referred to our institution for diagnosis and treatment. Computed tomography and magnetic resonance imaging showed a well-circumscribed smoothly marginated solid mass lesion in the pancreatic head. He underwent pyloric preserving pancreatoduodenectomy. Histopathological specimen revealed that the mass was located in the dilated branch duct of the pancreatic head, and an intraductal tubulopapillary neoplasm originating from the branch pancreatic duct was diagnosed. On magnetic resonance cholangiopancreatography, the mass within the dilated duct branch in the pancreatic head was similar to a “cast in the mold” image, which we retrospectively deemed, might be reflecting the nature of this tumor.

    DOI: 10.18999/nagjms.83.4.869

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  2. 【Precision Medicine時代のCardiac Imaging 2021 後編】MRI:循環器領域における臨床の最前線と技術の到達点 MRIの技術革新が広げる循環器画像診断の可能性 大血管の4D flow MRI

    櫻井 康雄, 竹原 康雄, 水野 崇, 阿部 真治, 長縄 慎二  

    INNERVISION36 巻 ( 5 ) 頁: 7 - 9   2021年4月

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    記述言語:日本語   出版者・発行元:(株)インナービジョン  

    MRIは、周辺技術の進歩により高画質、高速化が進められ、画像診断において重要な位置を占めている。MRによる生体内情報として、各組織のプロトンの密度、T1緩和、T2緩和、磁化率、拡散、血流、体液の流れ、灌流情報などの画像化、代謝情報が得られるが、その中で、血流や体液の流速を計測する試みは、位相コントラスト法を用いて古くから行われてきた。本稿では、血管領域に関する機能画像として、研究段階ではあるが、三次元の空間に時間軸情報を加えた三次元シネ位相コントラスト(phase contrast:PC)法である「4D flow MRI」について、主として大血管における現状を紹介する。(著者抄録)

  3. IVIMおよび灌流MRIを用いた免疫チェックポイント阻害剤投与後の腫瘍評価

    柄山 正人, 芳澤 暢子, 杉山 将隆, 森 和貴, 安井 秀樹, 井上 裕介, 穗積 宏尚, 鈴木 勇三, 古橋 一樹, 藤澤 朋幸, 榎本 紀之, 中村 祐太郎, 乾 直輝, 五島 聡, 須田 隆文, 竹原 康雄  

    日本呼吸器学会誌10 巻 ( 増刊 ) 頁: 156 - 156   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本呼吸器学会  

  4. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts 国際誌

    Hyodo R, Takehara Y, Mizuno T, Ichikawa K, Ishizu Y, Sugiyama M, Naganawa S  

    Hepatology research : the official journal of the Japan Society of Hepatology51 巻 ( 3 ) 頁: 343 - 349   2021年3月

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    記述言語:英語   出版者・発行元:Hepatology Research  

    Diagnosis and severity assessments of portosystemic shunts (PSSs) are important because the pathology sometimes results in severe hepatic encephalopathy, which can be treated almost completely by shunt embolization. At present, morphological assessment of PSS is performed mainly by computed tomography, and ultrasound is used for blood flow assessment. In two cases of PSS-related hepatic encephalopathy, we used time-resolved 3D cine phase-contrast (4D-flow) magnetic resonance imaging (MRI) to assess blood flow before and after shunt embolization. Before the intervention, blood flow in the main trunk of the superior mesenteric vein was mostly hepatofugal. However, post-interventional 4D-flow MRI revealed hepatopetal superior mesenteric vein flow with significantly increased portal vein blood flow. 4D-flow MRI is an ideal adjunct to Doppler ultrasonography, allowing for objective and visual assessment of morphology and blood flow of the portal venous system, including PSSs, and is useful in determining the indications for, and outcome of, PSS embolization.

    DOI: 10.1111/hepr.13616

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    PubMed

  5. 【画像診断に必要なartifactsの知識】MRIにおける注意すべきartifacts

    寺田 理希, 竹原 康雄  

    臨床放射線65 巻 ( 12 ) 頁: 1275 - 1294   2020年11月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    <文献概要>はじめに MRIでは,高度な静磁場均一性が必要とされる。また,信号の送受信や受信した信号による画像再構成には非常にデリケートなシステムが統合されている。撮影対象も様々な組織を含み,呼吸,拍動,蠕動といった生理的な動きをする生体が対象である。こうした多くの因子の複合として出来上がるMR画像では,アーチファクトから逃れられないと考えてよい。また,近年のMR装置では,パラレルイメージングや圧縮センシング(compressed sensing:CS),種々のK空間のデータ充填方法などにより高速化が可能となってきている。このため,撮像法に特有なアーチファクトが発生することも多くなっている。我々MRIに従事する医療者は,アーチファクトを認識すること,アーチファクトを防ぐ対応ができることが重要である。しかし,現実のMRIにおけるアーチファクトを画像内からまったくなくすことが難しい場合も多い。よって最適な対応として,アーチファクトを関心領域から除き,最小限にするなど様々な手法も必要となる。本稿では,基礎的なものから近年気になるアーチファクトまでを紹介し,要因・対応などについて紹介する。

    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01565&link_issn=&doc_id=20201125080004&doc_link_id=10.18888%2Frp.0000001434&url=https%3A%2F%2Fdoi.org%2F10.18888%2Frp.0000001434&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  6. 拡散強調MRIにおける非小細胞肺がんのADCヒストグラムの変化と免疫チェックポイント阻害剤の有効性との関連

    柄山 正人, 芳澤 暢子, 杉山 将隆, 森 和貴, 乾 直輝, 五島 聡, 須田 隆文, 竹原 康雄  

    肺癌60 巻 ( 6 ) 頁: 636 - 636   2020年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本肺癌学会  

  7. ロボット支援前立腺全摘除術後の難治性乳び腹水に対してリンパ管塞栓術が奏功した一例

    兵藤 良太, 山田 恵一郎, 堀口 瞭太, 伊藤 準, 松島 正哉, 駒田 智大, 大脇 貴之, 竹原 康雄, 長縄 慎二  

    日本インターベンショナルラジオロジー学会雑誌35 巻 ( Suppl. ) 頁: 290 - 290   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本インターベンショナルラジオロジー学会  

  8. 【ウイルス肝炎アップデート】診断 肝疾患評価におけるCT・MRI NAFLD・NASHを中心として

    竹原 康雄  

    診断と治療108 巻 ( 2 ) 頁: 197 - 204   2020年2月

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    記述言語:日本語   出版者・発行元:(株)診断と治療社  

    <Headline>1 慢性肝障害による肝線維化と肝細胞癌の発生リスクは、概ね直線関係である。2 DAAの出現で、慢性肝障害診療の関心はウイルス性肝炎による肝線維化からNAFLD・NASHによる肝線維化に移りつつある。3 肝特異性造影剤を用いた肝細胞癌の造影MRは異型腺腫様過形成の発癌リスクを知ることができ、介入治療のタイミングをはかるのに有用である。4 CT・MRIは肝の脂肪化定量、NAFLD・NASHの肝線維化、異型腺腫様過形成、肝細胞癌という一連の病態進行を非侵襲的、縦断的、one stop shop的に評価できる画像診断法である(著者抄録)

  9. 【MRIで読み解く心臓と脈管:流れと機能】腹部大動脈瘤の4D-flow

    杉山 将隆, 竹原 康雄  

    臨床画像36 巻 ( 1 ) 頁: 42 - 48   2020年1月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    4Dーflowにより,腹部大動脈内の三次元的な血流ベクトルデータを心時相分割表示することが可能で,血流動態を視覚的かつ定量的に評価することができるようになった。腹部大動脈瘤の形成にかかわる要因の探究から,治療効果の評価などに力を発揮する可能性を秘めている。(著者抄録)

    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01843&link_issn=&doc_id=20200107200005&doc_link_id=10.18885%2FCI.0000000106&url=https%3A%2F%2Fdoi.org%2F10.18885%2FCI.0000000106&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  10. ちょっと気になる胆・膵画像 ティーチングファイルから(第43回) 術前診断が困難であった膵lymphangiomaの1例

    小川 浩, 竹原 康雄, 長縄 慎二, 高見 秀樹, 中黒 匡人  

    胆と膵40 巻 ( 10 ) 頁: 841 - 844   2019年10月

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    記述言語:日本語   出版者・発行元:医学図書出版(株)  

  11. 【Step up MRI 2019 最新技術の研究開発・臨床応用から展望するMRIの未来】MRIの最新技術と未来展望 臨床編 4D-Flowを用いた血流解析の臨床応用 新しい診断リテラシーの現状と普及に向けての期待

    竹原 康雄  

    INNERVISION34 巻 ( 9 ) 頁: 45 - 48   2019年8月

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    記述言語:日本語   出版者・発行元:(株)インナービジョン  

    最近、3社のMRIメーカーから4D-Flowが臨床現場に導入された。データの後処理のための流体解析ソフトウエアを提供するメーカーも、筆者の知るかぎり9社を数える。今や4D-Flowは、すべての診療放射線技師や放射線科医、各科臨床医が知っておくべき診断リテラシーとなりつつある。本稿では、この分野に新規参入を検討されている研究者や臨床家をターゲットに、まず4D-Flowとは何か?そして、その臨床現場における現状と将来性について簡単に論じてみたい。(著者抄録)

  12. 【MRI Evolution 2019〜「測ってなんぼ!」MRIでの定量を考える〜】4D-Flowを用いた流体解析

    竹原 康雄  

    Rad Fan17 巻 ( 10 ) 頁: 37 - 40   2019年8月

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    記述言語:日本語   出版者・発行元:(株)メディカルアイ  

    4D-Flowは観察範囲内の全てのプロトンの速度ベクトルを遍く計測することのできる新しいMR技術である。3次元+時相分割で従来思いもよらなかった血行動態計測における乱流の問題が再認識されつつある。(著者抄録)

  13. MRIによる血流解析

    竹原 康雄  

    静脈学30 巻 ( 2 ) 頁: 102 - 102   2019年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本静脈学会  

  14. 【症候別画像診断プロトコル】3T MRI独特のシーケンス 自由呼吸下撮像

    小森 芳秋, 竹原 康雄  

    臨床画像35 巻 ( 4月増刊 ) 頁: 172 - 173   2019年4月

  15. 【症候別画像診断プロトコル】3T MRI独特のシーケンス 3D-GraSE法によるMRCP

    天野 智康, 高橋 護, 一条 勝利, 竹原 康雄  

    臨床画像35 巻 ( 4月増刊 ) 頁: 170 - 171   2019年4月

  16. 【症候別画像診断プロトコル】3T MRI独特のシーケンス 圧縮センシング

    寺田 理希, 竹原 康雄  

    臨床画像35 巻 ( 4月増刊 ) 頁: 166 - 168   2019年4月

  17. 外科診療に役立つ新しいMRI診断技術

    竹原 康雄  

    日本外科学会雑誌120 巻 ( 1 ) 頁: 56 - 61   2019年1月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

    MRの特徴は無被曝、低侵襲、組織特異性コントラスト、速度、拡散、弾性率、組織特異性造影剤の利用等多彩である。これらを駆使したMRI検査の外科診療への応用例を述べた。(著者抄録)

  18. 【膵癌update】診断 MRI/MRCP

    小川 浩, 竹原 康雄, 長縄 慎二  

    臨床消化器内科33 巻 ( 7 ) 頁: 789 - 793   2018年5月

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    記述言語:日本語   出版者・発行元:(株)日本メディカルセンター  

  19. 【大動脈疾患の画像診断:画像所見・画像からみた自然史・治療効果判定】大動脈疾患のMRI

    竹原 康雄  

    臨床画像34 巻 ( 1 ) 頁: 40 - 52   2018年1月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    MRAはガドリニウムキレート造影剤による造影MRAを基本とし、ほかの組織コントラストも併用することで、種々の大動脈疾患に対し、広い適応を有する。高速化による血行動態解析は大動脈解離やステントグラフト内挿術(EVAR,TEVAR)後のエンドリーク検出にも有用である。一時期問題となった腎性全身性線維症(NSF)も、現行のガイドラインが確定してから新たな患者は出現しておらず、また、NSFを起こしにくいマクロ環造影剤の出現や、非造影MRAの進歩などもMRAの安全性を高めている。MRAは現在高速化が進行中であり、今後、さらなる適応拡大が望めると考えられる。(著者抄録)

    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01843&link_issn=&doc_id=20180111090004&doc_link_id=10.18885%2FJ01843.2018090581&url=https%3A%2F%2Fdoi.org%2F10.18885%2FJ01843.2018090581&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  20. 【局所進行膵癌の治療限界に挑む】局所進行膵癌の術前治療後の画像診断

    小川 浩, 鈴木 耕次郎, 竹原 康雄, 長縄 慎二  

    胆と膵38 巻 ( 11 ) 頁: 1255 - 1260   2017年11月

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    記述言語:日本語   出版者・発行元:医学図書出版(株)  

    膵癌は、血管浸潤の範囲と遠隔転移・腹膜播種の有無により、切除可能、切除境界、切除不能に分類される。このうち、局所進行膵癌である切除境界および切除不能膵癌に関しては、化学療法あるいは化学放射線療法により癌細胞が減少し、外科的切除が可能となる症例が存在する。膵癌の治療効果判定は、CTやMRI、PETといった画像や、CA19-9などの腫瘍マーカーの推移でみるのが一般的である。ここでは、とくに局所進行膵癌の術前治療後の画像診断について述べ、さらに化学放射線療法後に生じる多彩な画像上の変化についても言及する。(著者抄録)

  21. 【圧縮センシングの旅-MRI高速化を探る-】圧縮センシング(CS)の現状 臨床MRIの知見と有用性

    寺田 理希, 松芳 圭吾, 小板橋 実夏, 安澤 千奈, 大杉 正典, 内藤 眞明, 沓掛 康道, 岩倉 岳史, 山中 典子, 吉原 和代, 吉原 修, 礒田 治夫, 竹原 康雄  

    Rad Fan15 巻 ( 15 ) 頁: 43 - 47   2017年11月

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    記述言語:日本語   出版者・発行元:(株)メディカルアイ  

    圧縮センシング(Compressed Sensing:CS)は、情報理論の分野において発展した手法をMRIに適応した高速撮像法であり注目される技術である。当院では、2017年8月にGEHC社製Discovery MR750 3.0TとOptima MR450W 1.5Tの2台のMRI装置のバージョンアップに伴いCSの使用が可能となった。現状でのCSにおける臨床応用の知見と有用性について紹介する。(著者抄録)

  22. ちょっと気になる胆・膵画像 ティーチングファイルから(第36回) 主膵管内腫瘍栓を呈した腺房細胞癌の1例

    小川 浩, 竹原 康雄, 館 靖, 長縄 慎二, 鈴木 耕次郎, 廣岡 芳樹, 山田 豪, 藤井 努, 下山 芳江  

    胆と膵38 巻 ( 10 ) 頁: 1131 - 1134   2017年10月

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    記述言語:日本語   出版者・発行元:医学図書出版(株)  

  23. MR Angiographyに関する最新技術と知見

    竹原 康雄  

    脈管学57 巻 ( Suppl. ) 頁: S94 - S95   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本脈管学会  

  24. 腹部MRIの最前線

    竹原 康雄  

    JART: 日本診療放射線技師会誌64 巻 ( 9 ) 頁: 1059 - 1059   2017年9月

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    記述言語:日本語   出版者・発行元:(公社)日本診療放射線技師会  

  25. 1.5T及び3.0T装置を用いた4D-Flowの精度の比較

    松本 卓弥, 天野 智康, 名倉 義和, 水野 孝一, 土屋 甲司, 高橋 護, 竹原 康雄  

    日本放射線技術学会雑誌73 巻 ( 9 ) 頁: 970 - 971   2017年9月

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    記述言語:日本語   出版者・発行元:(公社)日本放射線技術学会  

  26. MR用造影剤の安全性

    竹原 康雄  

    日本医学放射線学会秋季臨床大会抄録集53回 巻   頁: S388 - S388   2017年8月

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    記述言語:日本語   出版者・発行元:(公社)日本医学放射線学会  

  27. 血流速度に基づいたバイオマーカーによる脳動脈瘤増大とブレブ発生の予測の検討

    石黒 健太, 礒田 治夫, 水野 崇, 田嶋 駿亮, 竹原 康雄, 寺田 理希, 小杉 崇文, 大西 有希, 福山 篤司  

    日本バイオレオロジー学会誌(B&R)31 巻 ( 2 ) 頁: 85 - 85   2017年5月

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    記述言語:日本語   出版者・発行元:(NPO)日本バイオレオロジー学会  

  28. 腹部大動脈瘤ステントグラフト内挿術後2型エンドリーク症例の動脈瘤分枝血管に対する4D-flow MRIを用いた血行動態学的解析

    片橋 一人, 海野 直樹, 竹原 康雄, 山本 尚人, 犬塚 和徳, 佐野 真規, 斉藤 貴明, 杉澤 良太, 矢田 達朗, 嘉山 貴文, 今野 弘之  

    日本外科学会定期学術集会抄録集117回 巻   頁: SF - 6   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本外科学会  

  29. 【最新分類に基づく画像による悪性腫瘍の病期診断2017】膵癌

    牛尾 貴輔, 阪原 晴海, 竹原 康雄  

    臨床画像33 巻 ( 4月増刊 ) 頁: 140 - 148   2017年4月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

    2016年に『膵癌取扱い規約』(第7版)が発行され,新たな規約では切除可能性分類が明記され国際分類との整合性が保たれる形となった。また,一部には日本独自となる分類も含まれている。本稿では,実際の症例を提示しつつ膵癌の典型像および局所進展,切除可能性分類について述べた。(著者抄録)

    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01843&link_issn=&doc_id=20170410300010&doc_link_id=10.18885%2FJ01843.2017206467&url=https%3A%2F%2Fdoi.org%2F10.18885%2FJ01843.2017206467&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  30. 診断に苦慮した悪性黒色腫の1例

    兵頭 直子, 那須 初子, 廣瀬 裕子, 汪 洋, 大石 愛, 杉山 将隆, 宇佐美 諭, 伊東 洋平, 平井 雪, 芳澤 暢子, 牛尾 孝輔, 山下 修平, 神谷 実佳, 竹原 康雄, 阪原 晴海  

    Japanese Journal of Radiology35 巻 ( Suppl. ) 頁: 25 - 25   2017年2月

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    記述言語:日本語   出版者・発行元:(公社)日本医学放射線学会  

  31. 激変する放射線医学 : RSNA2016印象記 技術開発が進むMRI、その中に大きなトレンドの姿を見た

    竹原 康雄  

    月刊新医療44 巻 ( 2 ) 頁: 153 - 155   2017年2月

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    記述言語:日本語   出版者・発行元:エム・イー振興協会  

    CiNii Books

▼全件表示

Works(作品等) 8

  1. ジーイー横河メディカルシステム株式会社 多コイル感度エンコーディング法による超高速撮像法の実用化

    2003年

  2. 日本シェーリング株式会社 新しい組織・病変特異性MR造影剤の研究

    2003年

  3. 光ケミカル研究所(岡山)“金属ポルフィリンMR造影剤の開発”

  4. 東京女子医大消化器病センター(東京)“MRCPによる慢性膵炎診断能”

  5. 静岡大学工学部(浜松)“デンドリマー型MR造影剤研究”

  6. 聖隷三方原病院消化器病センター(浜松)“MRCPによる慢性膵炎診断能”

  7. 聖隷三方原病院放射線科,循環器科(浜松)“循環器MR臨床研究”

  8. 産業技術総合研究所ライフエレクトロニクス研究ラボ医用ビジョングループ(大阪)“磁気共鳴 画像法を用いた小動物の画像化の研究”

▼全件表示

科研費 6

  1. 大動脈ステントグラフト術後タイプ2エンドリークに対する新規診断・治療戦略の開発

    研究課題/研究課題番号:22K08917  2022年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    杉本 昌之, 児玉 章朗, 竹原 康雄, 坂野 比呂志, 川井 陽平

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    担当区分:研究分担者 

    腹部大動脈ステントグラフト留置術(EVAR)後の「type 2 endoleak」( T2EL)は高頻度の合併症であるが治療方針のエビデンスは乏しい。4D-flow MRは血行動態という「動的」要因を非侵襲的に評価可能である。本研究はEVAR患者を対象とし、1)4D-flow MRでT2ELによる瘤内圧変化や血液流入といった「動的」因子を定量化するとともに、2)EVAR後の中~長期成績(瘤径、T2EL、再治療)を観察する。データ解析によってT2ELの病態解明とT2EL治療の最適化と長期予後改善を目指す。

  2. 流体構造連成解析による大動脈瘤成長・破裂のリスク予測システムの開発

    研究課題/研究課題番号:21H02868  2021年4月 - 2024年3月

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    竹原 康雄, 牛尾 貴輔, 杉本 昌之, 礒田 治夫, 杉山 将隆, 滝沢 研二, 板谷 慶一, 駒田 智大, 兵藤 良太

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    担当区分:研究代表者 

    配分額:17420000円 ( 直接経費:13400000円 、 間接経費:4020000円 )

    血管内部に血流の乱れが生ずると壁の内皮細胞は摩擦力(壁剪断応力)の低下として感知し、流速を維持するため、内腔を狭くするための動脈硬化性物質を分泌し、動脈硬化が進行することがわかっている。こうして壁の脆弱性が生ずると、大動脈壁は血圧に負けて膨隆するが、膨隆した流路内では更に乱流が生ずることが数値流体力学(CFD)から知られている。この流れの変化と構造の変化の相互作用を繰り返して計算することにより、将来の構造を予測するのが流体構造連成解析(FSI)である。この研究は、FSIを用いて、現在の大動脈の形態から将来の動脈瘤の形状とその増大速度を推測し、介入の適応や時期を決定可能なシステム開発を目指す。

  3. 腹部大動脈瘤ステントグラフト内挿術後の諸問題解決を目指すMRIの新戦略

    研究課題/研究課題番号:17K10398  2017年4月 - 2020年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    竹原 康雄

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    担当区分:研究代表者 

    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    腹部大動脈瘤に対するEVAR後に最も頻度が高く瘤破裂という重大な結果を生ずる可能性のある問題点にエンドリークがある。これをMRIを用いて早期に正確に診断する方法を確立することが本研究の目的である。本研究により、type IIエンドリーク(EL2)のうち、分枝動脈内血流の流速の振幅が大きいほうが、瘤の増大と関係することが突き止められた。
    また、type Iエンドリーク(EL1), type IIIエンドリーク(EL3) では、瘤内の流線解析で、検出できる可能性が示唆された。また、造影MR angiography上で瘤内への造影剤の漏出の検出感度が、造影CTやX線DSAに勝っていることが確認された。
    高齢化が加速する本邦にあって、低侵襲治療であるEVARは今後も増加してゆく可能性が高いが、そのトレンドにあって、瘤破裂につながりかねないEVAR後のエンドリークの問題解決は焦眉の急と考えられる。本研究では、侵襲性の低い造影MR angiographyや4D Flow MRIといった新しい方法で従来法よりも高い感度でエンドリークを診断できる可能性が示された。流れという従来あまり利用されてこなかった学術的にも新規な方法論によって、腹部大動脈瘤の自然史解明につながる知見が得られた意義は大きい。

  4. 腹部大動脈瘤ステントグラフト内挿術後の諸問題解決を目指すMRIの新戦略

    2017年 - 2020年

    文部科学省  科学研究費補助金(基盤研究C) 

    竹原 康雄

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    担当区分:研究代表者  資金種別:競争的資金

  5. 腹部大動脈瘤術後2型エンドリークに対する血行動態学的予後予測因子の探索的研究

    研究課題/研究課題番号:16K15629  2016年4月 - 2019年3月

    日本学術振興会  科学研究費助成事業 挑戦的萌芽研究  挑戦的萌芽研究

    海野 直樹, 犬塚 和徳, 山本 尚人, 竹原 康雄

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    腹部大動脈瘤ステントグラフト内挿術 (EVAR) 後の2型エンドリーク (T2EL) が問題である。待機的EVAR症例に対して術後7日目のCT と4dimensional flow-sensitive MRI (4D-flow MRI) を用いて1年後のT2EL遺残の血行動態学的予後指標を探索した。1年後のEL遷延血管群ではEL消失群に比し、毎分あたりの血流量絶対値が有意に高かった。また瘤径増大群は非増大群に比して個々の瘤に属するT2EL血管の血流量絶対値の総和が有意に高かった。以上から4D-flow MRIによるT2ELの血行動態解析は、EL血管の血流遺残と1年後の瘤径増大予測に有用である。

  6. 核磁気共鳴エラストグラフィーによる頭蓋内腫瘍の弾性率の解析

    研究課題/研究課題番号:15K10359  2015年4月 - 2018年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    酒井 直人

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    担当区分:研究分担者 

    脳神経外科手術において頭蓋内腫瘍の硬さは手術の難易度を左右する。核磁気共鳴エラストグラフィー(MRE)は非侵襲的に生体内に組織の弾性率、すなわち硬さを測定することができる画期的な方法である。我々は、MREを用いて代表的な4つの頭蓋内腫瘍:髄膜腫、下垂体腺腫、前庭神経鞘腫、グリオーマに対してMREを用いて術前に弾性率を評価し術中の硬さとの相関について研究を行った。その結果、術前のMREの弾性率と術中の腫瘍の硬さは相関した。MREは術前に硬い腫瘍を鑑別するのに有用と考えた。

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担当経験のある科目 (本学以外) 10

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    浜松医科大学医学部大学院)

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  3. 胸部画像診断(医学部医学科6年生)(90分1コマ)

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    浜松医科大学医学部看護学科)

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    浜松医科大学医学部看護学科)

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    浜松医科大学医学部医学科)

  7. ユニット3 腹部画像診断(医学部医学科3年生)90分1コマ

    浜松医科大学医学部医学科)

  8. ユニット3 胸部画像診断(医学部医学科3年生)90分1コマ

    浜松医科大学医学部医学科)

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    浜松医科大学医学部医学科)

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