Updated on 2021/12/06

写真a

 
HASEGAWA Seiji
 
Organization
Graduate School of Medicine Nagoya University-MENARD Collaborative Research Chair Industry-Academia Collaborative Chair Designated associate professor
Title
Designated associate professor

Degree 1

  1. 薬学博士 ( 2002.3   名古屋市立大学 ) 

Research Interests 3

  1. Dermatology

  2. Regenerative medicine

  3. Stem cell

Research Areas 2

  1. Life Science / Dermatology  / Dermatology

  2. Life Science / Cell biology  / Stem cell

Current Research Project and SDGs 1

  1. 皮膚及び皮下脂肪組織由来幹細胞を用いた再生医療技術の開発

Awards 1

  1. 第8回 中部科学技術センター顕彰 大賞

    公益財団法人 中部科学技術センター   幹細胞および再生医療研究を応用した化粧品の開発と更なる新展開

 

Papers 43

  1. Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin

    Kawagishi-Hotta Mika, Hasegawa Seiji, Inoue Yu, Hasebe Yuichi, Arima Masaru, Iwata Yohei, Sugiura Kazumitsu, Akamatsu Hirohiko

    REGENERATIVE THERAPY   Vol. 18   page: 191 - 201   2021.12

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  2. Search for genetic loci involved in the constitution and skin type of a Japanese women using a genome-wide association study

    Inoue Yu, Hasebe Yuichi, Igarashi Toshio, Kawagishi-Hotta Mika, Okuno Ryosuke, Yamada Takaaki, Hasegawa Seiji

    EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 12 ) page: 1787 - 1793   2021.12

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  3. Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor

    Inoue Yu, Hasegawa Seiji, Hasebe Yuichi, Kawagishi-Hotta Mika, Okuno Ryosukc, Yamada Takaaki, Adachi Hiroaki, Miyachi Katsuma, Ishii Yoshie, Sugiura Kazumitsu, Akamatsu Hirohiko

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 44 ( 10 ) page: 1403 - 1412   2021.10

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  4. Senescent cell removal via JAG1-NOTCH1 signalling in the epidermis

    Yoshioka Hisashi, Yamada Takaaki, Hasegawa Seiji, Miyachi Katsuma, Ishii Yoshie, Hasebe Yuichi, Inoue Yu, Tanaka Hiroshi, Iwata Yohei, Arima Masaru, Sugiura Kazumitsu, Akamatsu Hirohiko

    EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 9 ) page: 1268 - 1278   2021.9

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  5. SASP-induced macrophage dysfunction may contribute to accelerated senescent fibroblast accumulation in the dermis

    Ogata Yuichiro, Yamada Takaaki, Hasegawa Seiji, Sanada Ayumi, Iwata Yohei, Arima Masaru, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 1 ) page: 84 - 91   2021.1

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  6. Gremlin 2 increased in the skin with age as a senescence-associated secretory phenotype factor

    Kawagishi-Hotta Mika, Hasegawa Seiji, Hasebe Yuichi, Sugiura Kazumitsu, Akamatsu Hirohiko

    JOURNAL OF DERMATOLOGY   Vol. 47 ( 12 ) page: 1457 - 1458   2020.12

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  7. Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis

    Kawagishi-Hotta Mika, Hasegawa Seiji, Igarashi Toshio, Date Yasushi, Ishii Yoshie, Inoue Yu, Hasebe Yuichi, Yamada Takaaki, Arima Masaru, Iwata Yohei, Kobayashi Tsukane, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    REGENERATIVE THERAPY   Vol. 11   page: 324 - 330   2019.12

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  8. ENDOGENOUS DERMAL STEM CELLS AS BIOMARKERS FOR SKIN WOUND HEALING

    Iwata Y., Akamatsu H., Hasebe Y., Hasegawa S., Nakata S., Sugiura K.

    WOUND REPAIR AND REGENERATION   Vol. 27 ( 5 ) page: A1 - A1   2019.9

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    Language:Japanese  

    Web of Science

  9. UV irradiation-induced DNA hypomethylation around WNT1 gene: Implications for solar lentigines

    Yamada Takaaki, Hasegawa Seiji, Iwata Yohei, Arima Masaru, Kobayashi Tsukane, Numata Shigeki, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    EXPERIMENTAL DERMATOLOGY   Vol. 28 ( 6 ) page: 723 - 729   2019.6

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  10. CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration

    Yamada Takaaki, Hasegawa Seiji, Hasebe Yuichi, Kawagishi-Hotta Mika, Arima Masaru, Iwata Yohei, Kobayashi Tsukane, Numata Shigeki, Yamamoto Naoki, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    ARCHIVES OF DERMATOLOGICAL RESEARCH   Vol. 311 ( 1 ) page: 55 - 62   2019.1

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  11. Extracellular proteoglycan decorin maintains human hair follicle stem cells

    Miyachi Katsuma, Yamada Takaaki, Kawagishi-Hotta Mika, Hasebe Yuichi, Date Yasushi, Hasegawa Seiji, Arima Masaru, Iwata Yohei, Kobayashi Tsukane, Numata Shigeki, Yamamoto Naoki, Nakata Satoru, Sugiura Kazumitsu, Akamatsu Hirohiko

    JOURNAL OF DERMATOLOGY   Vol. 45 ( 12 ) page: 1403 - 1410   2018.12

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  12. Development of 3D imaging technique of reconstructed human epidermis with immortalized human epidermal cell line

    Inoue Yu, Hasegawa Seiji, Miyachi Katsuma, Yamada Takaaki, Nakata Satoru, Ipponjima Sari, Hibi Terumasa, Nemoto Tomomi, Tanaka Masahiko, Suzuki Ryo, Hirashima Naohide

    EXPERIMENTAL DERMATOLOGY   Vol. 27 ( 5 ) page: 563 - 570   2018.5

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  13. Laminin-332 regulates differentiation of human interfollicular epidermal stem cells

    Yamada Takaaki, Hasegawa Seiji, Miyachi Katsuma, Date Yasushi, Inoue Yu, Yagami Akiko, Arima Masaru, Iwata Yohei, Yamamoto Naoki, Nakata Satoru, Matsunaga Kayoko, Sugiura Kazumitsu, Akamatsu Hirohiko

    MECHANISMS OF AGEING AND DEVELOPMENT   Vol. 171   page: 37 - 46   2018.4

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  14. Localization of collagen type 5 in the papillary dermis and its role in maintaining stem cell functions

    Hasebe Yuichi, Hasegawa Seiji, Date Yasushi, Nakata Satoru, Yagami Akiko, Iwata Yohei, Sugiura Kazumitsu, Akamatsu Hirohiko

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 89 ( 2 ) page: 205 - 207   2018.2

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  15. Enhancement of individual differences in proliferation and differentiation potentials of aged human adipose-derived stem cells

    Kawagishi-Hotta Mika, Hasegawa Seiji, Igarashi Toshio, Yamada Takaaki, Takahashi Masayuki, Numata Shigeki, Kobayashi Tsukane, Iwata Yohei, Arima Masaru, Yamamoto Naoki, Yagami Akiko, Nakata Satoru, Uzawa Tohru, Matsunaga Kayoko, Sugiura Kazumitsu, Akamatsu Hirohiko

    REGENERATIVE THERAPY   Vol. 6   page: 29 - 40   2017.6

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  16. Dermal CD271(+) Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process

    Iwata Yohei, Hasebe Yuichi, Hasegawa Seiji, Nakata Satoru, Yagami Akiko, Matsunaga Kayoko, Sugiura Kazumitsu, Akamatsu Hirohiko

    ACTA DERMATO-VENEREOLOGICA   Vol. 97 ( 5 ) page: 593 - 600   2017.5

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  17. Skin-resident stem cells and wound healing.

    Iwata Y, Akamatsu H, Hasebe Y, Hasegawa S, Sugiura K

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   Vol. 40 ( 1 ) page: 1 - 11   2017

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    Language:Japanese  

    DOI: 10.2177/jsci.40.1

    PubMed

  18. Age-related decrease in CD271(+) cells in human skin. Invited Reviewed

    Akamatsu H, Hasegawa S, Yamada T, Mizutani H, Nakata S, Yagami A, Matsunaga K.

    J Dermatol.   Vol. 43   page: 311 - 313   2016

  19. Inhibitory effect of Phalaenopsis orchid extract on WNT1-induced immature melanocyte precursor differentiation in a novel in vitro solar lentigo model. Invited Reviewed

    Yamada T, Hasegawa S, Inoue Y, Kunita M, Ohsumi K, Sakaida T, Yashiro Y, Nakata S.

    Biosci Biotechnol Biochem.   Vol. 80   page: 1321 - 1326   2016

  20. Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. Invited Reviewed

    Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H.

    Exp Dermatol.   Vol. 24   page: 552 - 554   2015

  21. ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation. Invited Reviewed

    Inoue Y, Hasegawa S, Ban S, Yamada T, Date Y, Mizutani H, Nakata S, Tanaka M, Hirashima N.

    J Biol Chem.   Vol. 289   page: 21451 - 21562   2014

  22. Comprehensive analysis of melanogenesis and proliferation potential of melanocyte lineage in solar lentigines. Invited Reviewed

    Yamada T, Hasegawa S, Inoue Y, Date Y, Arima M, Yagami A, Iwata Y, Abe M, Takahashi M, Yamamoto N, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

    J Dermatol Sci.   Vol. 73   page: 251 - 257   2014

  23. Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae. Invited Reviewed

    Yamada T, Hasegawa S, Inoue Y, Date Y, Arima M, Yagami A, Iwata Y, Takahashi M, Yamamoto N, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

    Exp Dermatol.   Vol. 23   page: 652 - 658   2014

  24. Histologic study of collagen and stem cells after radiofrequency treatment for aging skin. Invited Reviewed

    Yokoyama Y, Akita H, Hasegawa S, Negishi K, Akamatsu H, Matsunaga K.

    Dermatol Surg.   Vol. 40   page: 390 - 397   2014

  25. Major amino acids in collagen hydrolysate regulate the differentiation of mouse embryoid bodies. Invited Reviewed

    Date Y, Hasegawa S, Yamada T, Inoue Y, Mizutani H, Nakata S, Akamatsu H.

    J Biosci Bioeng.   Vol. 11   page: 386 - 390   2013

  26. Lignin Induces ES Cells to Differentiate into Neuroectodermal Cells through Mediation of the Wnt Signaling Pathway. Invited Reviewed

    Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Akamatsu H.

    PLoS One.   Vol. 8   page: e66376   2013

  27. Protective effect of hochuekkito, a Kampo prescription, against ultraviolet B irradiation-induced skin damage in hairless mice. Invited Reviewed

    Yanagihara S, Kobayashi H, Tamiya H, Tsuruta D, Okano Y, Takahashi K, Masaki H, Yamada T, Hasegawa S, Akamatsu H, Ishii M.

    J Dermatol.   Vol. 40   page: 201 - 206   2013

  28. Wnt/β-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation. Invited Reviewed

    Yamada T, Hasegawa S, Inoue Y, Date Y, Yamamoto N, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

    J Invest Dermatol.   Vol. 133   page: 2755 - 2762   2013

  29. The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers. Invited Reviewed

    J Dermatol Sci.   Vol. 71   page: 122 - 129   2013

  30. Analysis of the effects of hydroquinone and arbutin on the differentiation of melanocytes. Invited Reviewed

    Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

    Biol Pharm Bull.   Vol. 36   page: 1722 - 1730   2013

  31. Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea. Invited Reviewed

    Takahashi M, Akamatsu H, Yagami A, Hasegawa S, Ohgo S, Abe M, Iwata Y, Arima M, Mizutani H, Nakata S, Matsunaga K.

    J Dermatol.   Vol. 40   page: 720 - 725   2013

  32. Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-β1. Invited Reviewed

    Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H.

    Exp Dermatol.   Vol. 22   page: 769 - 771   2013

  33. Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis. Invited Reviewed

    Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

    Pigment Cell Melanoma Res.   Vol. 25   page: 299 - 311   2012

  34. Analysis of cell characterization using cell surface markers in the dermis. Invited Reviewed

    Hasebe Y, Hasegawa S, Hashimoto N, Toyoda M, Matsumoto K, Umezawa A, Yagami A, Matsunaga K, Mizutani H, Nakata S, Akamatsu H.

    J Dermatol Sci.   Vol. 62   page: 98 - 106   2011

  35. Age-related changes of p75 neurotrophin receptor-positive adipose-derived stem cells. Invited Reviewed

    Yamada T, Akamatsu H, Hasegawa S, Yamamoto N, Yoshimura T, Hasebe Y, Inoue Y, Mizutani H, Uzawa T, Matsunaga K, Nakata S.

    J Dermatol Sci.   Vol. 58   page: 36 - 42   2010

  36. Melanocyte stem cells express receptors for canonical Wnt-signaling pathway on their surface. Invited Reviewed

    Yamada T, Akamatsu H, Hasegawa S, Inoue Y, Date Y, Mizutani H, Yamamoto N, Matsunaga K, Nakata S.

    Biochem Biophys Res Commun.   Vol. 396   page: 837 - 842   2010

  37. Isolation of multipotent stem cells from mouse adipose tissue. Invited Reviewed

    Yamamoto N, Akamatsu H, Hasegawa S, Yamada T, Nakata S, Ohkuma M, Miyachi E, Marunouchi T, Matsunaga K.

    J Dermatol Sci.   Vol. 48   page: 43 - 52   2007

  38. Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery. Invited Reviewed

    Hasegawa S, Hirashima N, Nakanishi M.

    Bioorg Med Chem Lett.   Vol. 12   page: 1299 - 1302   2002

  39. Space-filling effects in membrane disruption by cationic amphiphiles. Invited Reviewed

    Fujiwara T, Hirashima N, Hasegawa S, Nakanishi M, Ohwada T.

    Bioorg Med Chem.   Vol. 9   page: 1013 - 1024   2002

  40. Anchoring and bola cationic amphiphiles for nucleotide delivery. Effects of orientation and extension of hydrophobic regions. Invited Reviewed

    Yoshimura T, Hasegawa S, Hirashima N, Nakanishi M, Ohwada T.

    Bioorg Med Chem Lett.   Vol. 11   page: 2897 - 2901   2001

  41. Microtubule involvement in the intracellular dynamics for gene transfection mediated by cationic liposomes. Invited Reviewed

    Hasegawa S, Hirashima N, Nakanishi M.

    Gene Ther.   Vol. 8   page: 1669 - 1673   2001

  42. Gene transfection activities of amphiphilic steroid-polyamine conjugates. Invited Reviewed

    Fujiwara T, Hasegawa S, Hirashima N, Nakanishi M, Ohwada T.

    Biochim Biophys Acta.   Vol. 1468   page: 396 - 402   2000

  43. Monosialoganglioside containing cationic liposomes with a cationic cholesterol derivative promote the efficiency of gene transfection in mammalian culture cells. Invited Reviewed

    Kawaura C, Hasegawa S, Hirashima N, Nakanishi M.

    Biol Pharm Bull.   Vol. 23   page: 778 - 780   2000

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MISC 19

  1. ときめきと脳血流の関連 -アイカラーの影響-

    浅井 雛代 , 広瀬 統 , 長谷川 靖司 , 中田 悟 , 杉浦 可奈 , 久世 淳子

    日本福祉大学健康科学論集   Vol. 23   page: 19 - 24   2020

  2. セラミド,メドウフォームエストリド,非極性油からなるオイルゲルとそれを利用したセラミド高配合油性製剤の開発

    熊谷 仁志 , 浅井 雛代 , 河野 賢治 , 浅野 浩志 , 広瀬 統 , 長谷川 靖司 , 澤田 均 , 北原 路郎 , 中田 悟

    日本化粧品技術者会誌   Vol. 54 ( 2 ) page: 138 - 143   2020

  3. 加齢によるIGFBP-4の増加は皮膚の老化を引き起こす

    奥野 凌輔 , 田中 浩 , 長谷川 靖司 , 中田 悟

    日本化粧品技術者会誌   Vol. 54 ( 1 ) page: 33 - 41   2020

  4. 女性のときめきに関する研究2:-アイカラー使用による心理・生体指標の変化-

    久世 淳子 , 杉浦 可奈 , 浅井 雛代 , 広瀬 統 , 長谷川 靖司 , 中田 悟

    日本健康心理学会大会発表論文集   Vol. 32   page: 134   2019

  5. 女性の「ときめき」尺度の作成

    浅井 雛代 , 山本 彩子 , 広瀬 統 , 長谷川 靖司 , 中田 悟 , 久世 淳子

    日本福祉大学健康科学論集   Vol. 22   page: 9 - 17   2019

  6. NHE1の機能低下は皮膚の保湿およびバリア機能に影響する

    村上 祐子 , 奥野 凌輔 , 田中 浩 , 長谷川 靖司 , 八代 洋一 , 中田 悟

    日本香粧品学会誌   Vol. 43 ( 1 ) page: 1 - 7   2019

  7. 女性のときめきに関する研究1:-尺度の作成と高級化粧品による心理・生体変化-

    浅井 雛代 , 山本 彩子 , 五十嵐 敏夫 , 広瀬 統 , 長谷川 靖司 , 中田 悟 , 久世 淳子

    日本健康心理学会大会発表論文集   Vol. 32   page: 112   2019

  8. ノブドウエキス含有飲料による膝関節の違和感等の改善効果

    松本 知大, 渡邊 明子 , 髙木 寛 , 長谷川 靖司 , 中田 悟 , 田中 宏幸

    日本補完代替医療学会誌   Vol. 15 ( 1 ) page: 9 - 14   2018

  9. 皮膚幹細胞の活性化によるアンチエイジングの新展開

    長谷川 靖司 , 赤松 浩彦

    デルマ   Vol. 262   page: 91 - 99   2017

  10. 皮膚内在性幹細胞と創傷治癒

    岩田 洋平 , 赤松 裕彦 , 長谷部 祐一 , 長谷川 靖司 , 杉浦 一充

    日本臨床免疫学会会誌   Vol. 40 ( 1 ) page: 1 - 11   2017

  11. 幹細胞が切り拓く近未来の美容と健康

    長谷川 靖司

    日本食品機械研究会誌   Vol. 36 ( 3 ) page: 29 - 34   2016

  12. 皮膚の幹細胞をターゲットにした化粧品の開発

    長谷川 靖司

    Cosmetic stage   Vol. 9 ( 8 ) page: 29 - 34   2015

  13. 皮膚のエイジングと幹細胞

    長谷川 靖司, 赤松 浩彦

    Cosmetic stage   Vol. 9 ( 8 ) page: 17 - 23   2015

  14. 幹細胞をターゲットにした再生美容

    長谷川 靖司, 赤松 浩彦

    美肌食品素材の評価と開発     2013

  15. 皮膚の幹細胞研究の進展と再生医療実用化に向けた将来展望

    長谷川 靖司, 赤松 浩彦

    先端医療に関する医療ニーズ/製品開発戦略と臨床で使わなくなる(であろう)薬剤・製品 予測     2012

  16. ハムスターおよびヒト皮脂腺の組織片培養法

    赤松 浩彦, 長谷川 靖司

    機能性化粧品素材開発のための実験プロトコール     page: 183 - 188   2010

  17. ハムスター皮脂腺由来培養脂腺細胞、脂質合成量の評価法

    赤松 浩彦, 長谷川 靖司

    機能性化粧品素材開発のための実験プロトコール     page: 189 - 194   2010

  18. 再生医療

    長谷川 靖司, 赤松 浩彦

    美容皮膚科改訂版2版     page: 129 - 135   2009

  19. 皮膚に浸透し光老化にともなうシワを防ぐコラーゲンペプチド

    田中 浩, 長谷川 靖司

    バイオインダストリー   Vol. 22 ( 9 ) page: 18 - 23   2005

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Presentations 2

  1. 皮膚幹細胞研究の美容分野への応用 Invited

    長谷川 靖司

    第30回 日本美容皮膚科学会総会・学術大会  2012.8.18  日本美容皮膚科学会

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    Event date: 2012.8

  2. 皮膚の幹細胞とアンチエイジングに向けた研究 Invited

    長谷川 靖司

    第25回 日本形成外科学会・基礎学術集会  2016.9.15 

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    Event date: 2016.9