Melanin accumulation in dermal stem cells deteriorates their exosome-mediated skin basement membrane construction in solar lentigo

Miyachi, K; Yamada, T; Sanada, A; Inoue, Y; Hasebe, Y; Arima, M; Iwata, Y; Hasegawa, S; Sugiura, K; Akamatsu, H

EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 12 ) page： 1881 - 1890   2022.12

Identification of mitochondrial genetic variants associated with human corneocyte size in Japanese women

Inoue, Y; Igarashi, T; Hasebe, Y; Kawagishi-Hotta, M; Okuno, R; Yamada, T; Hasegawa, S

EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 12 ) page： 1944 - 1948   2022.12

Genome-wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging

Okuno, R; Inoue, Y; Hasebe, Y; Igarashi, T; Kawagishi-Hotta, M; Yamada, T; Hasegawa, S

EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 9 ) page： 1411 - 1420   2022.9

Analysis of the effect of daily stress on the skin and search for genetic loci involved in the perceived stress of an individual.

Inoue Y, Hasebe Y, Igarashi T, Kawagishi-Hotta M, Okuno R, Yamada T, Hasegawa S

Skin health and disease   Vol. 2 ( 3 ) page： e110   2022.9

Age-related decrease in responsiveness of CD271-positive skin stem cells to growth factors

Akamatsu, H; Yamada, T; Sanada, A; Ishii, Y; Iwata, Y; Arima, M; Hasegawa, S; Sugiura, K

EXPERIMENTAL DERMATOLOGY   Vol. 31 ( 8 ) page： 1264 - 1269   2022.8

Enhanced Type I Collagen Synthesis in Fibroblasts by Dermal Stem/Progenitor Cell-Derived Exosomes

Sanada, A; Yamada, T; Hasegawa, S; Ishii, Y; Hasebe, Y; Iwata, Y; Arima, M; Sugiura, K; Akamatsu, H

BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 45 ( 7 ) page： 872 - 880   2022.7

Increase in inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging

Kawagishi-Hotta, M; Hasegawa, S; Hasebe, Y; Inoue, Y; Okuno, R; Arima, M; Iwata, Y; Sugiura, K; Akamatsu, H

JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 106 ( 3 ) page： 150 - 158   2022.6

UVA causes dysfunction of ETBR and BMPR2 in vascular endothelial cells, resulting in structural abnormalities of the skin capillaries

Miyachi, K; Murakami, Y; Inoue, Y; Yoshioka, H; Hirose, O; Yamada, T; Hasegawa, S; Arima, M; Iwata, Y; Sugiura, K; Akamatsu, H

JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 105 ( 2 ) page： 121 - 129   2022.2

Search for genetic loci involved in the constitution and skin type of a Japanese women using a genome-wide association study

Inoue, Y; Hasebe, Y; Igarashi, T; Kawagishi-Hotta, M; Okuno, R; Yamada, T; Hasegawa, S

EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 12 ) page： 1787 - 1793   2021.12

Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin

Kawagishi-Hotta, M; Hasegawa, S; Inoue, Y; Hasebe, Y; Arima, M; Iwata, Y; Sugiura, K; Akamatsu, H

REGENERATIVE THERAPY   Vol. 18   page： 191 - 201   2021.12

Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor

Inoue, Y; Hasegawa, S; Hasebe, Y; Kawagishi-Hotta, M; Okuno, R; Yamada, T; Adachi, H; Miyachi, K; Ishii, Y; Sugiura, K; Akamatsu, H

BIOLOGICAL & PHARMACEUTICAL BULLETIN   Vol. 44 ( 10 ) page： 1403 - 1412   2021.10

Senescent cell removal via JAG1-NOTCH1 signalling in the epidermis

Yoshioka, H; Yamada, T; Hasegawa, S; Miyachi, K; Ishii, Y; Hasebe, Y; Inoue, Y; Tanaka, H; Iwata, Y; Arima, M; Sugiura, K; Akamatsu, H

EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 9 ) page： 1268 - 1278   2021.9

SASP-induced macrophage dysfunction may contribute to accelerated senescent fibroblast accumulation in the dermis

Ogata, Y; Yamada, T; Hasegawa, S; Sanada, A; Iwata, Y; Arima, M; Nakata, S; Sugiura, K; Akamatsu, H

EXPERIMENTAL DERMATOLOGY   Vol. 30 ( 1 ) page： 84 - 91   2021.1

Gremlin 2 increased in the skin with age as a senescence-associated secretory phenotype factor

Kawagishi-Hotta, M; Hasegawa, S; Hasebe, Y; Sugiura, K; Akamatsu, H

JOURNAL OF DERMATOLOGY   Vol. 47 ( 12 ) page： 1457 - 1458   2020.12

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis

Kawagishi-Hotta, M; Hasegawa, S; Igarashi, T; Date, Y; Ishii, Y; Inoue, Y; Hasebe, Y; Yamada, T; Arima, M; Iwata, Y; Kobayashi, T; Nakata, S; Sugiura, K; Akamatsu, H

REGENERATIVE THERAPY   Vol. 11   page： 324 - 330   2019.12

ENDOGENOUS DERMAL STEM CELLS AS BIOMARKERS FOR SKIN WOUND HEALING

Iwata, Y; Akamatsu, H; Hasebe, Y; Hasegawa, S; Nakata, S; Sugiura, K

WOUND REPAIR AND REGENERATION   Vol. 27 ( 5 ) page： A1 - A1   2019.9

UV irradiation-induced DNA hypomethylation around <i>WNT1</i> gene: Implications for solar lentigines

Yamada, T; Hasegawa, S; Iwata, Y; Arima, M; Kobayashi, T; Numata, S; Nakata, S; Sugiura, K; Akamatsu, H

EXPERIMENTAL DERMATOLOGY   Vol. 28 ( 6 ) page： 723 - 729   2019.6

CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration

Yamada, T; Hasegawa, S; Hasebe, Y; Kawagishi-Hotta, M; Arima, M; Iwata, Y; Kobayashi, T; Numata, S; Yamamoto, N; Nakata, S; Sugiura, K; Akamatsu, H

ARCHIVES OF DERMATOLOGICAL RESEARCH   Vol. 311 ( 1 ) page： 55 - 62   2019.1

Extracellular proteoglycan decorin maintains human hair follicle stem cells

Miyachi, K; Yamada, T; Kawagishi-Hotta, M; Hasebe, Y; Date, Y; Hasegawa, S; Arima, M; Iwata, Y; Kobayashi, T; Numata, S; Yamamoto, N; Nakata, S; Sugiura, K; Akamatsu, H

JOURNAL OF DERMATOLOGY   Vol. 45 ( 12 ) page： 1403 - 1410   2018.12

Development of 3D imaging technique of reconstructed human epidermis with immortalized human epidermal cell line

Inoue, Y; Hasegawa, S; Miyachi, K; Yamada, T; Nakata, S; Ipponjima, S; Hibi, T; Nemoto, T; Tanaka, M; Suzuki, R; Hirashima, N

EXPERIMENTAL DERMATOLOGY   Vol. 27 ( 5 ) page： 563 - 570   2018.5

Laminin-332 regulates differentiation of human interfollicular epidermal stem cells

Yamada, T; Hasegawa, S; Miyachi, K; Date, Y; Inoue, Y; Yagami, A; Arima, M; Iwata, Y; Yamamoto, N; Nakata, S; Matsunaga, K; Sugiura, K; Akamatsu, H

MECHANISMS OF AGEING AND DEVELOPMENT   Vol. 171   page： 37 - 46   2018.4

Localization of collagen type 5 in the papillary dermis and its role in maintaining stem cell functions

Hasebe, Y; Hasegawa, S; Date, Y; Nakata, S; Yagami, A; Iwata, Y; Sugiura, K; Akamatsu, H

JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 89 ( 2 ) page： 205 - 207   2018.2

Enhancement of individual differences in proliferation and differentiation potentials of aged human adipose-derived stem cells

Kawagishi-Hotta, M; Hasegawa, S; Igarashi, T; Yamada, T; Takahashi, M; Numata, S; Kobayashi, T; Iwata, Y; Arima, M; Yamamoto, N; Yagami, A; Nakata, S; Uzawa, T; Matsunaga, K; Sugiura, K; Akamatsu, H

REGENERATIVE THERAPY   Vol. 6   page： 29 - 40   2017.6

Dermal CD271<SUP>+</SUP> Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process

Iwata, Y; Hasebe, Y; Hasegawa, S; Nakata, S; Yagami, A; Matsunaga, K; Sugiura, K; Akamatsu, H

ACTA DERMATO-VENEREOLOGICA   Vol. 97 ( 5 ) page： 593 - 600   2017.5

[Skin-resident stem cells and wound healing].

Iwata Y, Akamatsu H, Hasebe Y, Hasegawa S, Sugiura K

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   Vol. 40 ( 1 ) page： 1 - 11   2017

Age-related decrease in CD271(+) cells in human skin. Invited Reviewed

Akamatsu H, Hasegawa S, Yamada T, Mizutani H, Nakata S, Yagami A, Matsunaga K.

J Dermatol.   Vol. 43   page： 311 - 313   2016

Inhibitory effect of Phalaenopsis orchid extract on WNT1-induced immature melanocyte precursor differentiation in a novel in vitro solar lentigo model. Invited Reviewed

Yamada T, Hasegawa S, Inoue Y, Kunita M, Ohsumi K, Sakaida T, Yashiro Y, Nakata S.

Biosci Biotechnol Biochem.   Vol. 80   page： 1321 - 1326   2016

Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis. Invited Reviewed

Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H.

Exp Dermatol.   Vol. 24   page： 552 - 554   2015

ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation. Invited Reviewed

Inoue Y, Hasegawa S, Ban S, Yamada T, Date Y, Mizutani H, Nakata S, Tanaka M, Hirashima N.

J Biol Chem.   Vol. 289   page： 21451 - 21562   2014

Comprehensive analysis of melanogenesis and proliferation potential of melanocyte lineage in solar lentigines. Invited Reviewed

Yamada T, Hasegawa S, Inoue Y, Date Y, Arima M, Yagami A, Iwata Y, Abe M, Takahashi M, Yamamoto N, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

J Dermatol Sci.   Vol. 73   page： 251 - 257   2014

Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae. Invited Reviewed

Yamada T, Hasegawa S, Inoue Y, Date Y, Arima M, Yagami A, Iwata Y, Takahashi M, Yamamoto N, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

Exp Dermatol.   Vol. 23   page： 652 - 658   2014

Histologic study of collagen and stem cells after radiofrequency treatment for aging skin. Invited Reviewed

Yokoyama Y, Akita H, Hasegawa S, Negishi K, Akamatsu H, Matsunaga K.

Dermatol Surg.   Vol. 40   page： 390 - 397   2014

Major amino acids in collagen hydrolysate regulate the differentiation of mouse embryoid bodies. Invited Reviewed

Date Y, Hasegawa S, Yamada T, Inoue Y, Mizutani H, Nakata S, Akamatsu H.

J Biosci Bioeng.   Vol. 11   page： 386 - 390   2013

Lignin Induces ES Cells to Differentiate into Neuroectodermal Cells through Mediation of the Wnt Signaling Pathway. Invited Reviewed

Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Akamatsu H.

PLoS One.   Vol. 8   page： e66376   2013

Protective effect of hochuekkito, a Kampo prescription, against ultraviolet B irradiation-induced skin damage in hairless mice. Invited Reviewed

Yanagihara S, Kobayashi H, Tamiya H, Tsuruta D, Okano Y, Takahashi K, Masaki H, Yamada T, Hasegawa S, Akamatsu H, Ishii M.

J Dermatol.   Vol. 40   page： 201 - 206   2013

Wnt/β-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation. Invited Reviewed

Yamada T, Hasegawa S, Inoue Y, Date Y, Yamamoto N, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

J Invest Dermatol.   Vol. 133   page： 2755 - 2762   2013

The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers. Invited Reviewed

J Dermatol Sci.   Vol. 71   page： 122 - 129   2013

Analysis of the effects of hydroquinone and arbutin on the differentiation of melanocytes. Invited Reviewed

Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

Biol Pharm Bull.   Vol. 36   page： 1722 - 1730   2013

Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea. Invited Reviewed

Takahashi M, Akamatsu H, Yagami A, Hasegawa S, Ohgo S, Abe M, Iwata Y, Arima M, Mizutani H, Nakata S, Matsunaga K.

J Dermatol.   Vol. 40   page： 720 - 725   2013

Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-β1. Invited Reviewed

Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H.

Exp Dermatol.   Vol. 22   page： 769 - 771   2013

Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis. Invited Reviewed

Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K, Akamatsu H.

Pigment Cell Melanoma Res.   Vol. 25   page： 299 - 311   2012

Analysis of cell characterization using cell surface markers in the dermis. Invited Reviewed

Hasebe Y, Hasegawa S, Hashimoto N, Toyoda M, Matsumoto K, Umezawa A, Yagami A, Matsunaga K, Mizutani H, Nakata S, Akamatsu H.

J Dermatol Sci.   Vol. 62   page： 98 - 106   2011

Age-related changes of p75 neurotrophin receptor-positive adipose-derived stem cells. Invited Reviewed

Yamada T, Akamatsu H, Hasegawa S, Yamamoto N, Yoshimura T, Hasebe Y, Inoue Y, Mizutani H, Uzawa T, Matsunaga K, Nakata S.

J Dermatol Sci.   Vol. 58   page： 36 - 42   2010

Melanocyte stem cells express receptors for canonical Wnt-signaling pathway on their surface. Invited Reviewed

Yamada T, Akamatsu H, Hasegawa S, Inoue Y, Date Y, Mizutani H, Yamamoto N, Matsunaga K, Nakata S.

Biochem Biophys Res Commun.   Vol. 396   page： 837 - 842   2010

Isolation of multipotent stem cells from mouse adipose tissue. Invited Reviewed

Yamamoto N, Akamatsu H, Hasegawa S, Yamada T, Nakata S, Ohkuma M, Miyachi E, Marunouchi T, Matsunaga K.

J Dermatol Sci.   Vol. 48   page： 43 - 52   2007

Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery. Invited Reviewed

Hasegawa S, Hirashima N, Nakanishi M.

Bioorg Med Chem Lett.   Vol. 12   page： 1299 - 1302   2002

Space-filling effects in membrane disruption by cationic amphiphiles. Invited Reviewed

Fujiwara T, Hirashima N, Hasegawa S, Nakanishi M, Ohwada T.

Bioorg Med Chem.   Vol. 9   page： 1013 - 1024   2002

Anchoring and bola cationic amphiphiles for nucleotide delivery. Effects of orientation and extension of hydrophobic regions. Invited Reviewed

Yoshimura T, Hasegawa S, Hirashima N, Nakanishi M, Ohwada T.

Bioorg Med Chem Lett.   Vol. 11   page： 2897 - 2901   2001

Microtubule involvement in the intracellular dynamics for gene transfection mediated by cationic liposomes. Invited Reviewed

Hasegawa S, Hirashima N, Nakanishi M.

Gene Ther.   Vol. 8   page： 1669 - 1673   2001

Gene transfection activities of amphiphilic steroid-polyamine conjugates. Invited Reviewed

Fujiwara T, Hasegawa S, Hirashima N, Nakanishi M, Ohwada T.

Biochim Biophys Acta.   Vol. 1468   page： 396 - 402   2000

Monosialoganglioside containing cationic liposomes with a cationic cholesterol derivative promote the efficiency of gene transfection in mammalian culture cells. Invited Reviewed

Kawaura C, Hasegawa S, Hirashima N, Nakanishi M.

Biol Pharm Bull.   Vol. 23   page： 778 - 780   2000

NHE1の機能低下は皮膚の保湿およびバリア機能に影響する

村上 祐子 , 奥野 凌輔 , 田中 浩 , 長谷川 靖司 , 八代 洋一 , 中田 悟

日本香粧品学会誌   Vol. 43 ( 1 ) page： 1 - 7   2019

女性のときめきに関する研究1:-尺度の作成と高級化粧品による心理・生体変化-

浅井 雛代 , 山本 彩子 , 五十嵐 敏夫 , 広瀬 統 , 長谷川 靖司 , 中田 悟 , 久世 淳子

日本健康心理学会大会発表論文集   Vol. 32   page： 112   2019

ノブドウエキス含有飲料による膝関節の違和感等の改善効果

松本 知大, 渡邊 明子 , 髙木 寛 , 長谷川 靖司 , 中田 悟 , 田中 宏幸

日本補完代替医療学会誌   Vol. 15 ( 1 ) page： 9 - 14   2018

皮膚幹細胞の活性化によるアンチエイジングの新展開

長谷川 靖司 , 赤松 浩彦

デルマ   Vol. 262   page： 91 - 99   2017

皮膚内在性幹細胞と創傷治癒

岩田 洋平 , 赤松 裕彦 , 長谷部 祐一 , 長谷川 靖司 , 杉浦 一充

日本臨床免疫学会会誌   Vol. 40 ( 1 ) page： 1 - 11   2017

幹細胞が切り拓く近未来の美容と健康

長谷川 靖司

日本食品機械研究会誌   Vol. 36 ( 3 ) page： 29 - 34   2016

皮膚の幹細胞をターゲットにした化粧品の開発

長谷川 靖司

Cosmetic stage   Vol. 9 ( 8 ) page： 29 - 34   2015

皮膚のエイジングと幹細胞

長谷川 靖司, 赤松 浩彦

Cosmetic stage   Vol. 9 ( 8 ) page： 17 - 23   2015

幹細胞をターゲットにした再生美容

長谷川 靖司, 赤松 浩彦

美肌食品素材の評価と開発     2013

皮膚の幹細胞研究の進展と再生医療実用化に向けた将来展望

長谷川 靖司, 赤松 浩彦

先端医療に関する医療ニーズ／製品開発戦略と臨床で使わなくなる（であろう）薬剤・製品 予測     2012

ハムスターおよびヒト皮脂腺の組織片培養法

赤松 浩彦, 長谷川 靖司

機能性化粧品素材開発のための実験プロトコール     page： 183 - 188   2010

ハムスター皮脂腺由来培養脂腺細胞、脂質合成量の評価法

赤松 浩彦, 長谷川 靖司

機能性化粧品素材開発のための実験プロトコール     page： 189 - 194   2010

再生医療

長谷川 靖司, 赤松 浩彦

美容皮膚科改訂版2版     page： 129 - 135   2009

皮膚に浸透し光老化にともなうシワを防ぐコラーゲンペプチド

田中 浩, 長谷川 靖司

バイオインダストリー   Vol. 22 ( 9 ) page： 18 - 23   2005