Faculty Profiles - ONO Daisuke

Papers - ONO Daisuke

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Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus Reviewed

Ono Daisuke, Wang Huan, Hung Chi Jung, Wang Hsin-tzu, Kon Naohiro, Yamanaka Akihiro, Li Yulong, Sugiyama Takashi

SCIENCE ADVANCES Vol. 9 ( 1 ) page： eabq7032 2023.1

The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus Reviewed

Ono Daisuke, Mukai Yasutaka, Hung Chi Jung, Chowdhury Srikanta, Sugiyama Takashi, Yamanaka Akihiro

SCIENCE ADVANCES Vol. 6 ( 45 ) 2020.11

Dissociation of Per1 and Bmal1 circadian rhythms in the suprachiasmatic nucleus in parallel with behavioral outputs. Reviewed

Ono D, Honma S, Nakajima Y, Kuroda S, Enoki R, Honma KI

Proceedings of the National Academy of Sciences of the United States of America Vol. 114 ( 18 ) page： E3699-E3708 2017.5

Differential roles of AVP and VIP signaling in the postnatal changes of neural networks for coherent circadian rhythms in the SCN. Reviewed

Ono D, Honma S, Honma K

Science advances Vol. 2 ( 9 ) page： e1600960 2016.9

Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus. Reviewed

Ono D, Honma S, Honma K

Nature communications Vol. 4 page： 1666 2013.4

The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward

Ono, D; Weaver, DR; Hastings, MH; Honma, KI; Honma, S; Silver, R

JOURNAL OF BIOLOGICAL RHYTHMS page： 7487304231225706 2024.2

Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.

Natsubori A, Hirai S, Kwon S, Ono D, Deng F, Wan J, Miyazawa M, Kojima T, Okado H, Karashima A, Li Y, Tanaka KF, Honda M

iScience Vol. 26 ( 1 ) page： 105830 2023.1

Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light-dark cycles in mice.

Li R, Masuda K, Ono D, Kanbayashi T, Hirano A, Sakurai T

Frontiers in neuroscience Vol. 17 page： 1201137 2023

Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations

Padlom Apirada, Ono Daisuke, Hamashima Rio, Furukawa Yuko, Yoshimura Takashi, Nishiwaki-Ohkawa Taeko

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 19519 2022.11

Neural circuits in the central circadian clock and their regulation of sleep and wakefulness in mammals

Ono Daisuke

NEUROSCIENCE RESEARCH Vol. 182 page： 1 - 6 2022.9

Functional Interaction Between GABAergic Neurons in the Ventral Tegmental Area and Serotonergic Neurons in the Dorsal Raphe Nucleus

Rahaman Sheikh Mizanur, Chowdhury Srikanta, Mukai Yasutaka, Ono Daisuke, Yamaguchi Hiroshi, Yamanaka Akihiro

FRONTIERS IN NEUROSCIENCE Vol. 16 page： 877054 2022.5

The Food-entrainable Oscillator Is a Complex of Non-SCN Activity Bout Oscillators Uncoupled From the SCN Circadian Pacemaker.

Nishide S, Suzuki Y, Ono D, Honma S, Honma KI

Journal of biological rhythms page： 7487304211047937 2021.10

CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN

Ono Daisuke, Honma Ken-ichi, Schmal Christoph, Takumi Toru, Kawamoto Takeshi, Fujimoto Katsumi, Kato Yukio, Honma Sato

SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 19240 2021.9

Editorial: Development of Circadian Clock Functions

Myung Jihwan, Nakamura Takahiro J., Jones Jeff R., Silver Rae, Ono Daisuke

FRONTIERS IN NEUROSCIENCE Vol. 15 page： 735007 2021.8

Reversible modulation of circadian time with chronophotopharmacology

Kolarski Dusan, Miro-Vinyals Carla, Sugiyama Akiko, Srivastava Ashutosh, Ono Daisuke, Nagai Yoshiko, Iida Mui, Itami Kenichiro, Tama Florence, Szymanski Wiktor, Hirota Tsuyoshi, Feringa Ben L.

NATURE COMMUNICATIONS Vol. 12 ( 1 ) page： 3164 2021.5

Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock

Ono Daisuke, Honma Ken-ichi, Honma Sato

FRONTIERS IN NEUROSCIENCE Vol. 15 page： 650154 2021.4

Corrigendum: Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock.

Ono D, Honma KI, Honma S

Frontiers in neuroscience Vol. 15 page： 810796 2021

Conditional Knockout of Bmal1 in Corticotropin-Releasing Factor Neurons Does Not Alter Sleep-Wake Rhythm in Mice.

Hung CJ, Yamanaka A, Ono D

Frontiers in neuroscience Vol. 15 page： 808754 2021

Prostaglandin E2Induces Long-Lasting Inhibition of Noradrenergic Neurons in the Locus Coeruleus and Moderates the Behavioral Response to Stressors

Yasutaka Mukai, Tatsuo S. Okubo, Michael Lazarus, Daisuke Ono, Kenji F. Tanaka, Akihiro Yamanaka

The Journal of Neuroscience Vol. 43 ( 47 ) page： 7982 - 7999 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Society for Neuroscience

Neuronal activity is modulated not only by inputs from other neurons but also by various factors, such as bioactive substances. Noradrenergic (NA) neurons in the locus coeruleus (LC-NA neurons) are involved in diverse physiological functions, including sleep/wakefulness and stress responses. Previous studies have identified various substances and receptors that modulate LC-NA neuronal activity through techniques including electrophysiology, calcium imaging, and single-cell RNA sequencing. However, many substances with unknown physiological significance have been overlooked. Here, we established an efficient screening method for identifying substances that modulate LC-NA neuronal activity through intracellular calcium ([Ca2+]i) imaging using brain slices. Using both sexes of mice, we screened 53 bioactive substances, and identified five novel substances: gastrin-releasing peptide, neuromedin U, and angiotensin II, which increase [Ca2+]i, and pancreatic polypeptide and prostaglandin D2, which decrease [Ca2+]i. Among them, neuromedin U induced the greatest response in female mice. In terms of the duration of [Ca2+]ichange, we focused on prostaglandin E2(PGE2), since it induces a long-lasting decrease in [Ca2+]ivia the EP3receptor. Conditional knock-out of the receptor in LC-NA neurons resulted in increased depression-like behavior, prolonged wakefulness in the dark period, and increased [Ca2+]iafter stress exposure. Our results demonstrate the effectiveness of our screening method for identifying substances that modulate a specific neuronal population in an unbiased manner and suggest that stress-induced prostaglandin E2can suppress LC-NA neuronal activity to moderate the behavioral response to stressors. Our screening method will contribute to uncovering previously unknown physiological functions of uncharacterized bioactive substances in specific neuronal populations.

SIGNIFICANCE STATEMENTBioactive substances modulate the activity of specific neuronal populations. However, since only a limited number of substances with predicted effects have been investigated, many substances that may modulate neuronal activity have gone unrecognized. Here, we established an unbiased method for identifying modulatory substances by measuring the intracellular calcium signal, which reflects neuronal activity. We examined noradrenergic (NA) neurons in the locus coeruleus (LC-NA neurons), which are involved in diverse physiological functions. We identified five novel substances that modulate LC-NA neuronal activity. We also found that stress-induced prostaglandin E2(PGE2) may suppress LC-NA neuronal activity and influence behavioral outcomes. Our screening method will help uncover previously overlooked functions of bioactive substances and provide insight into unrecognized roles of specific neuronal populations.

DOI： 10.1523/JNEUROSCI.0353-23.2023

Web of Science

PubMed

Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy

Hiroto Ito, Noriaki Fukatsu, Sheikh Mizanur Rahaman, Yasutaka Mukai, Shuntaro Izawa, Daisuke Ono, Thomas S. Kilduff, Akihiro Yamanaka

Proceedings of the National Academy of Sciences Vol. 120 ( 41 ) page： e2301951120 2023.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Proceedings of the National Academy of Sciences

Narcolepsy is a sleep disorder caused by deficiency of orexin signaling. However, the neural mechanisms by which deficient orexin signaling causes the abnormal rapid eye movement (REM) sleep characteristics of narcolepsy, such as cataplexy and frequent transitions to REM states, are not fully understood. Here, we determined the activity dynamics of orexin neurons during sleep that suppress the abnormal REM sleep architecture of narcolepsy. Orexin neurons were highly active during wakefulness, showed intermittent synchronous activity during non-REM (NREM) sleep, were quiescent prior to the transition from NREM to REM sleep, and a small subpopulation of these cells was active during REM sleep. Orexin neurons that lacked orexin peptides were less active during REM sleep and were mostly silent during cataplexy. Optogenetic inhibition of orexin neurons established that the activity dynamics of these cells during NREM sleep regulate NREM–REM sleep transitions. Inhibition of orexin neurons during REM sleep increased subsequent REM sleep in “orexin intact” mice and subsequent cataplexy in mice lacking orexin peptides, indicating that the activity of a subpopulation of orexin neurons during the preceding REM sleep suppresses subsequent REM sleep and cataplexy. Thus, these results identify how deficient orexin signaling during sleep results in the abnormal REM sleep architecture characteristic of narcolepsy.

DOI： 10.1073/pnas.2301951120

Web of Science

PubMed

GABAergic mechanisms in the suprachiasmatic nucleus that influence circadian rhythm Reviewed

Ono Daisuke, Honma Ken-ichi, Honma Sato

JOURNAL OF NEUROCHEMISTRY 2020.7

Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy Reviewed International coauthorship

Hung Chi Jung, Ono Daisuke, Kilduff Thomas S., Yamanaka Akihiro

ELIFE Vol. 9 2020.4

Controlling the Circadian Clock with High Temporal Resolution through Photodosing

Kolarski Dusan, Sugiyama Akiko, Breton Ghislain, Rakers Christin, Ono Daisuke, Schulte Albert, Tama Florence, Itami Kenichiro, Szymanski Wiktor, Hirota Tsuyoshi, Feringa Ben L.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 141 ( 40 ) page： 15784 - 15791 2019.10

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories

Izawa Shuntaro, Chowdhury Srikanta, Miyazaki Toh, Mukai Yasutaka, Ono Daisuke, Inoue Ryo, Ohmura Yu, Mizoguchi Hiroyuki, Kimura Kazuhiro, Yoshioka Mitsuhiro, Terao Akira, Kilduff Thomas S., Yamanaka Akihiro

SCIENCE Vol. 365 ( 6459 ) page： 1308 - + 2019.9

Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics

Schmal Christoph, Ono Daisuke, Myung Jihwan, Pett J. Patrick, Honma Sato, Honma Ken-Ichi, Herzel Hanspeter, Tokuda Isao T.

PLOS COMPUTATIONAL BIOLOGY Vol. 15 ( 9 ) page： e1007330 2019.9

GABA in the suprachiasmatic nucleus refines circadian output rhythms in mice Reviewed

Ono Daisuke, Honma Ken-ichi, Yanagawa Yuchio, Yamanaka Akihiro, Honma Sato

COMMUNICATIONS BIOLOGY Vol. 2 page： 232 2019.6

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

Chowdhury Srikanta, Matsubara Takanori, Miyazaki Toh, Ono Daisuke, Fukatsul Noriaki, Abe Manabu, Sakimura Kenji, Sudo Yuki, Yamanaka Akihiro

ELIFE Vol. 8 2019.6

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ.

2019.2

Coherency of circadian rhythms in the SCN is governed by the interplay of two coupling factors

Tokuda Isao T., Ono Daisuke, Honma Sato, Honma Ken-Ichi, Herzel Hanspeter

PLOS COMPUTATIONAL BIOLOGY Vol. 14 ( 12 ) page： e1006607 2018.12

Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus

Ono Daisuke, Honma Ken-ichi, Yanagawa Yuchio, Yamanaka Akihiro, Honma Sato

JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 68 ( 4 ) page： 333 - 343 2018.7

Hypothalamic regulation of the sleep/wake cycle. Reviewed

Ono D, Yamanaka A

Neuroscience research Vol. 118 page： 74-81 2017.5

Synchronous circadian voltage rhythms with asynchronous calcium rhythms in the suprachiasmatic nucleus. Reviewed

Enoki R, Oda Y, Mieda M, Ono D, Honma S, Honma KI

Proceedings of the National Academy of Sciences of the United States of America Vol. 114 ( 12 ) page： E2476-E2485 2017.3

Dual origins of the intracellular circadian calcium rhythm in the suprachiasmatic nucleus. Reviewed

Enoki R, Ono D, Kuroda S, Honma S, Honma KI

Scientific reports Vol. 7 page： 41733 2017.2

Coupling Controls the Synchrony of Clock Cells in Development and Knockouts. Reviewed

Tokuda IT, Ono D, Ananthasubramaniam B, Honma S, Honma K, Herzel H

Biophysical journal Vol. 109 ( 10 ) page： 2159-2170 2015.11

Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse. Reviewed

Tsuchiya Y, Minami Y, Umemura Y, Watanabe H, Ono D, Nakamura W, Takahashi T, Honma S, Kondoh G, Matsuishi T, Yagita K

Genes to cells : devoted to molecular & cellular mechanisms page： - 2015.10

Circadian PER2::LUC rhythms in the olfactory bulb of freely moving mice depend on the SCN but not on behavior rhythms. Reviewed

Ono D, Honma S, Honma KI

The European journal of neuroscience page： - 2015.10

Circadian and ultradian rhythms of clock gene expression in the suprachiasmatic nucleus of freely moving mice. Reviewed

Ono D, Honma K, Honma S

Scientific reports Vol. 5 page： 12310 2015.7

Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior rhythm. Reviewed

Mieda M, Ono D, Hasegawa E, Okamoto H, Honma K, Honma S, Sakurai T

Neuron Vol. 85 ( 5 ) page： 1103-1116 2015.3

Postnatal Constant Light Compensates Cryptochrome1 and 2 Double Deficiency for Disruption of Circadian Behavioral Rhythms in Mice under Constant Dark. Reviewed

Ono D, Honma S, Honma K

PloS one Vol. 8 page： e80615 2013.11

Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus. Reviewed

Enoki R, Kuroda S, Ono D, Hasan MT, Ueda T, Honma S, Honma KI

Proceedings of the National Academy of Sciences of the United States of America Vol. 109 ( 52 ) page： 21498-21503 2012.12

JNK regulates the photic response of the mammalian circadian clock. Reviewed

Yoshitane H, Honma S, Imamura K, Nakajima H, Nishide SY, Ono D, Kiyota H, Shinozaki N, Matsuki H, Wada N, Doi H, Hamada T, Honma K, Fukada Y

EMBO reports Vol. 13 page： 455-461 2012.5

Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system. Reviewed

Enoki R, Ono D, Hasan MT, Honma S, Honma K

Journal of neuroscience methods Vol. 207 ( 1 ) page： 72-79 2012.5

De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide. Reviewed

Nishide SY, Ono D, Yamada Y, Honma S, Honma K

The European journal of neuroscience Vol. 35 page： 291-299 2012.1

Suprachiasmatic nucleus: cellular clocks and networks. Reviewed

Honma S, Ono D, Suzuki Y, Inagaki N, Yoshikawa T, Nakamura W, Honma K

Progress in brain research Vol. 199 page： 129-141 2012

Clock mechanisms for seasonal adaptation: Morning and evening oscillators in the suprachiasmatic nucleus Reviewed

Honma S, Inagaki N, Ono D, Yoshikawa T, Hashimoto S, Honma K

Sleep and Biological rhythms Vol. 6 ( 2 ) page： 84-90 2008.4

A TTX-sensitive local circuit is involved in the expression of PK2 and BDNF circadian rhythms in the mouse suprachiasmatic nucleus. Reviewed

Baba K, Ono D, Honma S, Honma K

The European journal of neuroscience Vol. 27 page： 909-916 2008.2

Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity. Reviewed

Inagaki N, Honma S, Ono D, Tanahashi Y, Honma K

Proceedings of the National Academy of Sciences of the United States of America Vol. 104 ( 18 ) page： 7664-7669 2007.5

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Papers - ONO Daisuke