Organization
Nagoya University Hospital Psychiatry Lecturer
Title
Lecturer
External link
YAMAMOTO Maeri
Degree 1
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博士（医学） （ 2016.3 名古屋大学 ）
Papers 23
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Machine learning algorithm-based estimation model for the severity of depression assessed using Montgomery-Asberg depression rating scale Reviewed
Shimamoto M, Ishizuka K, Ohtani K, Inada T, Yamamoto M, Tachibana M, Kimura H, Sakai Y, Kobayashi K, Ozaki N, Ikeda M.
Neuropsychopharmacological Reports Vol. 44 ( 1 ) page： 115 - 120 2023.12
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Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case-control study. Reviewed
Lo T, Kushima I, Kimura H, Aleksic B, Okada T, Kato H, Inada T, Nawa Y, Torii Y, Yamamoto M, Kimura R, Funabiki Y, Kosaka H, Numata S, Kasai K, Sasaki T, Yokoyama S, Munesue T, Hashimoto R, Yasuda Y, Fujimoto M, Usami M, Itokawa M, Arai M, Ohi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Yamasue H, Iwata N, Ikeda M, Ozaki N.
Neuropsychopharmacol Report Vol. 44 ( 1 ) page： 42 - 50 2023.11
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Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals Reviewed
Matsumoto J, Fukunaga M, Miura K, Nemoto K, Okada N, Hashimoto N, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Ito S, Yamazaki R, Hasegawa N, Narita H, Yokoyama S, Mishima R, Miyata J, Kobayashi Y, Sasabayashi D, Harada K, Yamamoto M, Hirano Y, Itahashi T, Nakataki M, Hashimoto RI, Tha KK, Koike S, Matsubara T, Okada G, Yoshimura R, Abe O, van Erp TGM, Turner JA, Jahanshad N, Thompson PM, Onitsuka T, Watanabe Y, Matsuo K, Yamasue H, Okamoto Y, Suzuki M, Ozaki N, Kasai K, Hashimoto R.
Molecular Psychiatry Vol. 28 ( 11 ) page： 4915 - 4923 2023.8
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Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification Reviewed
Okada N, Fukunaga M, Miura K, Nemoto K, Matsumoto J, Hashimoto N, Kiyota M, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Hasegawa N, Narita H, Yokoyama S, Mishima R, Kawashima T, Kobayashi Y, Sasabayashi D, Harada K, Yamamoto M, Hirano Y, Itahashi T, Nakataki M, Hashimoto RI, Tha KK, Koike S, Matsubara T, Okada G, van Erp TGM, Jahanshad N, Yoshimura R, Abe O, Onitsuka T, Watanabe Y, Matsuo K, Yamasue H, Okamoto Y, Suzuki M, Turner JA, Thompson PM, Ozaki N, Kasai K, Hashimoto R.
Molecular Psychiatry 2023.8
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Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder Reviewed
Yamamoto M, Inada T
Jpn J Radiol 2022.12
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Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder.
Kushima I, Nakatochi M, Aleksic B, Okada T, Kimura H, Kato H, Morikawa M, Inada T, Ishizuka K, Torii Y, Nakamura Y, Tanaka S, Imaeda M, Takahashi N, Yamamoto M, Iwamoto K, Nawa Y, Ogawa N, Iritani S, Hayashi Y, Lo T, Otgonbayar G, Furuta S, Iwata N, Ikeda M, Saito T, Ninomiya K, Okochi T, Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Miura K, Itokawa M, Arai M, Miyashita M, Toriumi K, Ohi K, Shioiri T, Kitaichi K, Someya T, Watanabe Y, Egawa J, Takahashi T, Suzuki M, Sasaki T, Tochigi M, Nishimura F, Yamasue H, Kuwabara H, Wakuda T, Kato TA, Kanba S, Horikawa H, Usami M, Kodaira M, Watanabe K, Yoshikawa T, Toyota T, Yokoyama S, Munesue T, Kimura R, Funabiki Y, Kosaka H, Jung M, Kasai K, Ikegame T, Jinde S, Numata S, Kinoshita M, Kato T, Kakiuchi C, Yamakawa K, Suzuki T, Hashimoto N, Ishikawa S, Yamagata B, Nio S, Murai T, Son S, Kunii Y, Yabe H, Inagaki M, Goto YI, Okumura Y, Ito T, Arioka Y, Mori D, Ozaki N
Biological psychiatry Vol. 92 ( 5 ) page： 362 - 374 2022.9
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Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients
Nawa Yoshihiro, Kushima Itaru, Aleksic Branko, Yamamoto Maeri, Kimura Hiroyuki, Banno Masahiro, Hashimoto Ryota, Ozaki Norio
PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol. 76 ( 7 ) page： 338 - 339 2022.7
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Transdiagnostic comparisons of intellectual abilities and work outcome in patients with mental disorders: multicentre study
Sumiyoshi Chika, Ohi Kazutaka, Fujino Haruo, Yamamori Hidenaga, Fujimoto Michiko, Yasuda Yuka, Uno Yota, Takahashi Junichi, Morita Kentaro, Katsuki Asuka, Yamamoto Maeri, Okahisa Yuko, Sata Ayumi, Katsumoto Eiichi, Koeda Michihiko, Hirano Yoji, Nakataki Masahito, Matsumoto Junya, Miura Kenichiro, Hashimoto Naoki, Makinodan Manabu, Takahashi Tsutomu, Nemoto Kiyotaka, Kishimoto Toshifumi, Suzuki Michio, Sumiyoshi Tomiki, Hashimoto Ryota
BJPSYCH OPEN Vol. 8 ( 4 ) page： e98 2022.6
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Involvement of cerebellar and subcortical connector hubs in schizophrenia
Yamamoto Maeri, Bagarinao Epifanio, Shimamoto Masanori, Iidaka Tetsuya, Ozaki Norio
NEUROIMAGE-CLINICAL Vol. 35 page： 103140 2022
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Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites
Yamamoto Maeri, Bagarinao Epifanio, Kushima Itaru, Takahashi Tsutomu, Sasabayashi Daiki, Inada Toshiya, Suzuki Michio, Iidaka Tetsuya, Ozaki Norio
PLOS ONE Vol. 15 ( 11 ) 2020.11
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ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk
Sekiguchi Mariko, Sobue Akira, Kushima Itaru, Wang Chenyao, Arioka Yuko, Kato Hidekazu, Kodama Akiko, Kubo Hisako, Ito Norimichi, Sawahata Masahito, Hada Kazuhiro, Ikeda Ryosuke, Shinno Mio, Mizukoshi Chikara, Tsujimura Keita, Yoshimi Akira, Ishizuka Kanako, Takasaki Yuto, Kimura Hiroki, Xing Jingrui, Yu Yanjie, Yamamoto Maeri, Okada Takashi, Shishido Emiko, Inada Toshiya, Nakatochi Masahiro, Takano Tetsuya, Kuroda Keisuke, Amano Mutsuki, Aleksic Branko, Yamomoto Takashi, Sakuma Tetsushi, Aida Tomomi, Tanaka Kohichi, Hashimoto Ryota, Arai Makoto, Ikeda Masashi, Iwata Nakao, Shimamura Teppei, Nagai Taku, Nabeshima Toshitaka, Kaibuchi Kozo, Yamada Kiyofumi, Mori Daisuke, Ozaki Norio
TRANSLATIONAL PSYCHIATRY Vol. 10 ( 1 ) page： 247 2020.7
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White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals.
Koshiyama D, Fukunaga M, Okada N, Morita K, Nemoto K, Usui K, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Azechi H, Watanabe Y, Hashimoto N, Narita H, Kusumi I, Ohi K, Shimada T, Kataoka Y, Yamamoto M, Ozaki N, Okada G, Okamoto Y, Harada K, Matsuo K, Yamasue H, Abe O, Hashimoto R, Takahashi T, Hori T, Nakataki M, Onitsuka T, Holleran L, Jahanshad N, van Erp TGM, Turner J, Donohoe G, Thompson PM, Kasai K, Hashimoto R, COCORO.
Molecular psychiatry 2019.11
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Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism
Owada Keiho, Okada Takashi, Munesue Toshio, Kuroda Miho, Fujioka Toru, Uno Yota, Matsumoto Kaori, Kuwabara Hitoshi, Mori Daisuke, Okamoto Yuko, Yoshimura Yuko, Kawakubo Yuki, Arioka Yuko, Kojima Masaki, Yuhi Teruko, Yassin Walid, Kushima Itaru, Benner Seico, Ogawa Nanayo, Kawano Naoko, Eriguchi Yosuke, Uemura Yukari, Yamamoto Maeri, Kano Yukiko, Kasai Kiyoto, Higashida Haruhiro, Ozaki Norio, Kosaka Hirotaka, Yamasue Hidenori
BRAIN Vol. 142 ( 7 ) page： 2127-2136 2019.7
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Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder Reviewed
Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N.
Neuropsychopharmacol Rep 2019.6
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Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights
Kushima Itaru, Aleksic Branko, Nakatochi Masahiro, Shimamura Teppei, Okada Takashi, Uno Yota, Morikawa Mako, Ishizuka Kanako, Shiino Tomoko, Kimura Hiroki, Arioka Yuko, Yoshimi Akira, Takasaki Yuto, Yu Yanjie, Nakamura Yukako, Yamamoto Maeri, Iidaka Tetsuya, Iritani Shuji, Inada Toshiya, Ogawa Nanayo, Shishido Emiko, Torii Youta, Kawano Naoko, Omura Yutaka, Yoshikawa Toru, Uchiyama Tokio, Yamamoto Toshimichi, Ikeda Masashi, Hashimoto Ryota, Yamamori Hidenaga, Yasuda Yuka, Someya Toshiyuki, Watanabe Yuichiro, Egawa Jun, Nunokawa Ayako, Itokawa Masanari, Arai Makoto, Miyashita Mitsuhiro, Kobori Akiko, Suzuki Michio, Takahashi Tsutomu, Usami Masahide, Kodaira Masaki, Watanabe Kyota, Sasaki Tsukasa, Kuwabara Hitoshi, Tochigi Mamoru, Nishimura Fumichika, Yamasue Hidenori, Eriguchi Yosuke, Benner Seico, Kojima Masaki, Yassin Walid, Munesue Toshio, Yokoyama Shigeru, Kimura Ryo, Funabiki Yasuko, Kosaka Hirotaka, Ishitobi Makoto, Ohmori Tetsuro, Numata Shusuke, Yoshikawa Takeo, Toyota Tomoko, Yamakawa Kazuhiro, Suzuki Toshimitsu, Inoue Yushi, Nakaoka Kentaro, Goto Yu-ichi, Inagaki Masumi, Hashimoto Naoki, Kusumi Ichiro, Son Shuraku, Murai Toshiya, Ikegame Tempei, Okada Naohiro, Kasai Kiyoto, Kunimoto Shohko, Mori Daisuke, Iwata Nakao, Ozaki Norio
CELL REPORTS Vol. 24 ( 11 ) page： 2838-2856 2018.9
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Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia
Yamamoto Maeri, Kushima Itaru, Suzuki Ryohei, Branko Aleksic, Kawano Naoko, Inada Toshiya, Iidaka Tetsuya, Ozaki Norio
PSYCHIATRY RESEARCH-NEUROIMAGING Vol. 278 page： 35 - 41 2018.8
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Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia
Sobue Akira, Kushima Itaru, Nagai Taku, Shan Wei, Kohno Takao, Aleksic Branko, Aoyama Yuki, Mori Daisuke, Arioka Yuko, Kawano Naoko, Yamamoto Maeri, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio
SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 13046 2018.8
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Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.
Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H
Molecular psychiatry 2018.6
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The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects
Hashimoto Naoki, Ito Yoichi M., Okada Naohiro, Yamamori Hidenaga, Yasuda Yuka, Fujimoto Michiko, Kudo Noriko, Takemura Ariyoshi, Son Shuraku, Narita Hisashi, Yamamoto Maeri, Tha Khin Khin, Katsuki Asuka, Ohi Kazutaka, Yamashita Fumio, Koike Shinsuke, Takahashi Tsutomu, Nemoto Kiyotaka, Fukunaga Masaki, Onitsuka Toshiaki, Watanabe Yoshiyuki, Yamasue Hidenori, Suzuki Michio, Kasai Kiyoto, Kusumi Ichiro, Hashimoto Ryota
NEUROIMAGE-CLINICAL Vol. 17 page： 563-569 2018
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White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects Reviewed
Yamamoto M, Kushima I, Kimura H, Hayashi A, Kawano N, Aleksic B, Iidaka T, Ozaki N
Brain and Behavior Vol. 5 ( 10 ) 2015.9
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The effects of acute treatment with ramelteon, triazolam, and placebo on driving performance, cognitive function, and equilibrium function in healthy volunteers Reviewed
Miyata A, Iwamoto K, Kawano N, Kohmura K, Yamamoto M, Aleksic B, Ebe K, Noda A, Noda Y, Iritani S, Ozaki N.
Psychopharmacology 2014.12
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Effects of low-dose mirtazapine on driving performance in healthy volunteers Reviewed
Iwamoto K, Kawano N, Sasada K, Kohmura K, Yamamoto M, Ebe K, Noda Y, Ozaki N.
Hum Psychopharmacol 2013.9
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Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers Reviewed
Sasada K, Iwamoto K, Kawano N, Kohmura K, Yamamoto M, Aleksic B, Ebe K, Noda Y, Ozaki N.
Hum Psychopharmacol. 2013.5
KAKENHI (Grants-in-Aid for Scientific Research) 2
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統合失調症における加齢に伴う脳神経回路病態を解明する
Grant number： 21K07498 2021.4 - 2024.3
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統合失調症の発症リスクとなるゲノムコピー数変異が脳内ネットワークに与える影響
Grant number：17K10295 2017.4 - 2021.3
山本 真江里
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
研究代表者等は、大規模なゲノムコピー数変異(CNV)解析を実施し、統合失調症の発症に強い影響を及ぼすCNVを多数同定した。CNVが、脳の発達に重要な遺伝子の機能に影響を及ぼすことで神経発達障害が起こり、発症に繋がると推測される。本研究では、この結果をもとに、MRIを用いて高解像度T1画像、拡散テンソル 画像、安静時fMRI画像を取得し、発症関連CNVが統合失調症の脳の構造や脳内ネットワークの結合性に与える影響を検討する。
今年度は、自閉スペクトラム症の患者において15q11.2-q13.1重複という自閉スペクトラム症では最も有名な変異を同定し、MRI撮像を行った。今後は、iPS細胞の樹立を計画しMRI解析結果と合わせて評価する予定である。
また、統合失調症患者(SCZ)と健常者(CON)をサポートベクターマシンを用いて判別する方法を検討した。名古屋大学で取得したMRIデータ（SCZ50名、CON51名）を用いて判別器を学習させ、富山大学で取得したMRIデータ（SCZ49名、CON48名）で判別器の精度を評価した。トレーニングデータの判別精度は73.3％、テストデータの精度は72.2％（感度：61.2％、特異度：83.3％、陽性適中率：78.9％、陰性適中率：67.8％）であった。判別に関与した領域は、両側内側前頭皮質、側頭極、島皮質、および左舌回であった 。本研究においてSVMによる判別方法は、異なるプロトコルおよびMRI装置を使用して撮像した独立したデータセットにおいてもほぼ同じ精度を達成した。現在、英文雑誌に投稿準備中である。
本研究では、名古屋大学・脳とこころの研究センターに設置されているMRI装置を使用しMRIデータを集積しているが、装置の不具合により、データ収集に遅れが生じている。現在は、装置は修復されており来年度は引き続きデータ収集を継続する予定である。
ゲノムコピー数変異を持つ患者は、精神症状が重篤であることが多く、病状によりMRIデータが取得できないこともデータ収集が遅延している理由である。
当初３年間の研究期間を予定していたが、データ収集に遅延が生じているため、補助事業期間の延長を申請し承認を得た。来年度も引き続きMRiデータおよび臨床データの収集を継続する予定である。発症関連CNVと統合失調症の脳内ネットワークの障害との関連を検討すると共に、臨床データ（陽性・陰性症状評価尺度や知的機能の簡易評価など）と脳内ネットワークの障害との関連についても検討する。