Organization
Nagoya University Hospital Maternity and Perinatal Care Center Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
IMAI Kenji
Degree 1
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医学博士 （ 2016.3 名古屋大学 ）
Research Areas 1
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Life Science / Obstetrics and gynecology
Current Research Project and SDGs 1
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早産病態の研究および新規治療戦略の探求
Awards 1
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日本産科婦人科学会優秀演題賞
2015.4 名古屋大学産婦人科
Papers 78
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Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy.
Ushida T, Tano S, Imai K, Matsuo S, Kajiyama H, Kotani T
Hypertension research : official journal of the Japanese Society of Hypertension 2024.3
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Ohori, Y; Imai, K; Tano, S; Owaki, T; Miki, R; Nozaki, Y; Ushida, T; Kajiyama, H; Kotani, T
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2024.1
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Matsuo, S; Ushida, T; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T
REPRODUCTIVE BIOMEDICINE ONLINE Vol. 47 ( 6 ) page： 103331 2023.12
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Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery.
Mizutani H, Ushida T, Ozeki K, Tano S, Iitani Y, Imai K, Nishiwaki K, Kajiyama H, Kotani T
International journal of obstetric anesthesia page： 103957 2023.11
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Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles
Iitani, Y; Miki, R; Imai, K; Fuma, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T
PEDIATRIC RESEARCH Vol. 95 ( 1 ) page： 167 - 173 2023.9
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New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan
Ushida Takafumi, Nakamura Noriyuki, Katsuki Satoru, Mizutani Hidesuke, Iitani Yukako, Imai Kenji, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
HYPERTENSION RESEARCH 2023.7
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Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model
Nakamura Noriyuki, Ushida Takafumi, Onoda Atsuto, Ueda Kazuto, Miura Ryosuke, Suzuki Toshihiko, Katsuki Satoru, Mizutani Hidesuke, Yoshida Kosuke, Tano Sho, Iitani Yukako, Imai Kenji, Hayakawa Masahiro, Kajiyama Hiroaki, Sato Yoshiaki, Kotani Tomomi
FRONTIERS IN PEDIATRICS Vol. 11 page： 1168173 2023.7
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Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan
Imai Kenji, Nozaki Yuki, Ushida Takafumi, Tano Sho, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 49 ( 9 ) page： 2317 - 2323 2023.6
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Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants
Nosaka Rena, Ushida Takafumi, Kidokoro Hiroyuki, Kawaguchi Masahiro, Shiraki Anna, Iitani Yukako, Imai Kenji, Nakamura Noriyuki, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi
ARCHIVES OF GYNECOLOGY AND OBSTETRICS 2023.5
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Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels
Fuma Kazuya, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Iitani Yukako, Nakamura Noriyuki, Miki Rika, Katsuki Satoru, Kinoshita Fumie, Sato Yoshiaki, Hayakawa Masahiro, Kajiyama Hiroaki
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2023.2
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Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan
Imai Kenji, Aoki Chieko, Tano Sho, Iitani Yukako, Nakamura Noriyuki, Ushida Takafumi, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2023.2
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Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study
Tano Sho, Kotani Tomomi, Ushida Takafumi, Iitani Yukako, Imai Kenji, Kinoshita Fumie, Kajiyama Hiroaki
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY Vol. 21 ( 1 ) page： 7 2023.1
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Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature
Kotani Tomomi, Tsuda Hiroyuki, Ito Yumiko, Nakamura Noriyuki, Ushida Takafumi, Imai Kenji, Iitani Yukako, Fuma Kazuya, Muramatsu Yukako, Hayakawa Masahiro, Kajiyama Hiroaki
JOURNAL OF MEDICAL CASE REPORTS Vol. 16 ( 1 ) page： 481 2022.12
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Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning
Ushida Takafumi, Kotani Tomomi, Baba Joji, Imai Kenji, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki
ARCHIVES OF GYNECOLOGY AND OBSTETRICS 2022.12
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A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review
Tano Sho, Kotani Tomomi, Yoshihara Masato, Nakamura Noriyuki, Matsuo Seiko, Ushida Takafumi, Imai Kenji, Ito Miharu, Oka Yasuyoshi, Sato Emi, Hayashi Shin, Ogi Tomoo, Kajiyama Hiroaki
MOLECULAR GENETICS AND METABOLISM REPORTS Vol. 33 page： 100925 2022.12
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Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis
Ushida Takafumi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Fuma Kazuya, Iitani Yukako, Imai Kenji, Sato Yoshiaki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi, Japan Neonatal Research Network Of
ARCHIVES OF GYNECOLOGY AND OBSTETRICS 2022.11
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Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells
Aoki Chieko, Imai Kenji, Mizutani Teruyuki, Sugiyama Daisuke, Miki Rika, Koya Yoshihiro, Kobayashi Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Owaki Taro, Nishikawa Hiroyoshi, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi
LIFE SCIENCES Vol. 308 page： 120955 2022.11
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5p deletion with congenital diaphragmatic hernia: a case report
Kotani Tomomi, Ushida Takafumi, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Tano Sho, Iwagaki Shigenori, Takahashi Yuichiro, Ito Miharu, Hayakawa Masahiro, Kajiyama Hiroaki
JOURNAL OF MEDICAL CASE REPORTS Vol. 16 ( 1 ) page： 390 2022.10
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Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy
Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki
SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 17502 2022.10
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DEVELOPING OF A NOVEL THERAPEUTIC AGENT FOR FGR THROUGH DRUG REPOSITIONING
Tano Sho, Kotani Tomomi, Ushida Takafumi, Nakamura Noriyuki, Iitani Yukako, Yoshihara Masato, Imai Kenji, Kajiyama Hiroaki
PLACENTA Vol. 128 page： 124 - 124 2022.10
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Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population
Ushida Takafumi, Matsuo Seiko, Nakamura Noriyuki, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 48 ( 7 ) page： 1760 - 1767 2022.7
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Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants
Ushida Takafumi, Kotani Tomomi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH Vol. 28 page： 174 - 179 2022.6
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The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia
Aoki Chieko, Imai Kenji, Owaki Taro, Kobayashi-Nakano Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Kajiyama Hiroaki, Kotani Tomomi
MEDICINA-LITHUANIA Vol. 58 ( 6 ) 2022.6
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Machine learning prediction models for postpartum depression: A multicenter study in Japan
Matsuo Seiko, Ushida Takafumi, Emoto Ryo, Moriyama Yoshinori, Iitani Yukako, Nakamura Noriyuki, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Matsui Shigeyuki, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 2022.4
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Pregnancy Outcomes in Women with Thyroid Diseases.
Kotani T, Imai K, Ushida T, Moriyama Y, Nakano-Kobayashi T, Osuka S, Tsuda H, Sumigama S, Yamamoto E, Kinoshita F, Hirakawa A, Iwase A, Kikkawa F, Kajiyama H
JMA journal Vol. 5 ( 2 ) page： 216 - 223 2022.4
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Assessment of placental abruption with diffusion-weighted imaging
Mizutani Teruyuki, Kotani Tomomi, Kato Noriko, Imai Kenji, Ushida Takafumi, Nakano-Kobayashi Tomoko, Kinoshita Yoshimi, Ito Masato, Kinoshita Fumie, Yamamuro Osamu, Kajiyama Hiroaki
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 48 ( 4 ) page： 930 - 937 2022.4
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Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy
Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki
FRONTIERS IN ENDOCRINOLOGY Vol. 13 page： 815390 2022.3
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Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan
Matsuo Seiko, Ushida Takafumi, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
ARCHIVES OF WOMENS MENTAL HEALTH Vol. 25 ( 1 ) page： 181 - 189 2022.2
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Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study
Katsuki Satoru, Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Iitani Yukako, Fuma Kazuya, Imai Kenji, Nakano-Kobayashi Tomoko, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi
EARLY HUMAN DEVELOPMENT Vol. 163 page： 105479 2021.12
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Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan
Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH Vol. 26 page： 48 - 53 2021.12
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Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy
Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 22519 2021.11
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Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study
Fujita Kei, Ushida Takafumi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Matsuo Seiko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 47 ( 11 ) page： 3867 - 3874 2021.11
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Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction
Nomoto Masataka, Kotani Tomomi, Miki Rika, Ushida Takafumi, Imai Kenji, Iitani Yukako, Tano Sho, Wang Jingwen, Moriyama Yoshinori, Kobayashi Tomoko, Mimura Nobuko, Iriyama Takayuki, Kikkawa Fumitaka, Kajiyama Hiroaki
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 69 ( 3 ) page： 280 - 285 2021.11
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Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey
Fujita Kei, Kotani Tomomi, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Kobayashi-Nakano Tomoko, Kato Noriko, Kano Takeo, Kikkawa Fumitaka, Kajiyama Hiroaki
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH Vol. 18 ( 17 ) 2021.9
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Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia
Miura Mayo, Imai Kenji, Tsuda Hiroyuki, Miki Rika, Tano Sho, Ito Yumiko, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Iitani Yukako, Nakano-Kobayashi Tomoko, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 22 ( 17 ) 2021.9
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Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study
Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Katsuki Satoru, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH Vol. 25 page： 143 - 149 2021.8
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Antenatal prediction models for short- and medium-term outcomes in preterm infants
Ushida Takafumi, Moriyama Yoshinori, Nakatochi Masahiro, Kobayashi Yumiko, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA Vol. 100 ( 6 ) page： 1089 - 1096 2021.6
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Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders
Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kinoshita Fumie, Nakamura Noriyuki, Iitani Yukako, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH Vol. 24 page： 73 - 78 2021.6
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Assessment of myocardial performance index in late-onset fetal growth restriction
Tran Thao Nguyen Nguyen, Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Kobayashi Tomoko, Niimi Kaoru, Sumigama Seiji, Yamamoto Eiko, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Kikkawa Fumitaka
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 2 ) page： 259 - 268 2021.5
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Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis
Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Hindmarch Charles C. T., Cotechini Tiziana, Imai Kenji, Nakano-Kobayashi Tomoko, Kajiyama Hiroaki, Graham Charles H.
REPRODUCTION Vol. 161 ( 5 ) page： 513 - 522 2021.5
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Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia
Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 700 page： 108769 2021.3
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Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report
Nakamura Noriyuki, Ushida Takafumi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Osuka Satoko, Goto Maki, Kajiyama Hiroaki, Asada Hideyuki, Hayakawa Masahiro, Kotani Tomomi
JOURNAL OF MEDICAL CASE REPORTS Vol. 15 ( 1 ) page： 114 2021.3
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Maternal low birth weight and hypertensive disorders of pregnancy
Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH Vol. 23 page： 5 - 10 2021.3
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Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study
Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kikkawa Fumitaka
SHOCK Vol. 55 ( 3 ) page： 332 - 337 2021.3
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Liver transaminase levels during pregnancy: a Japanese multicenter study
Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE page： 1 - 7 2021.2
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Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage
Owaki Taro, Imai Kenji, Miki Rika, Niwa Yuri, Kotani Tomomi, Nakano-Kobayashi Tomoko, Ushida Takafumi, Kajiyama Hiroaki
CYTOKINE Vol. 138 page： 155406 2021.2
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Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy Reviewed
SCIENTIFIC REPORTS Vol. 11 ( 1 ) 2021.1
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Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study
Ushida Takafumi, Kotani Tomomi, Hayakawa Masahiro, Hirakawa Akihiro, Sadachi Ryo, Nakamura Noriyuki, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kikkawa Fumitaka
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 9312 2020.6
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Antenatal Corticosteroids and Outcomes in Preterm Twins Reviewed
OBSTETRICS AND GYNECOLOGY Vol. 135 ( 6 ) page： 1387 - 1397 2020.6
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A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia.
Tachi A, Moriyama Y, Tsuda H, Miki R, Ushida T, Miura M, Ito Y, Imai K, Nakano-Kobayashi T, Hayakawa M, Kikkawa F, Kotani T
Nagoya journal of medical science Vol. 82 ( 2 ) page： 345 - 354 2020.5
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Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings Reviewed
Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Kobayashi Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka
Vol. 127 2020.3
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Adverse effects of endometriosis on pregnancy: a case-control study Reviewed
Miura Mayo, Ushida Takafumi, Imai Kenji, Wang Jingwen, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Kikkawa Fumitaka, Kotani Tomomi
BMC PREGNANCY AND CHILDBIRTH Vol. 19 ( 1 ) 2019.10
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A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases Reviewed
Niwa Yuri, Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka
JOURNAL OF CLINICAL ULTRASOUND Vol. 47 ( 8 ) page： 494 - 496 2019.10
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Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study. Reviewed
Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Vol. 32 ( 16 ) page： 2633 - 2637 2019.8
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Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management Reviewed
Imai Kenji, Kotani Tomomi, Ushida Takafumi, Moriyama Yoshinori, Nakano Tomoko, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 39 ( 6 ) page： 757 - 762 2019.8
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Somatic symptom disorder manifested as acute abdominal pain during pregnancy preceding perinatal depression: a case report
Moriyama Yoshinori, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
ARCHIVES OF WOMENS MENTAL HEALTH Vol. 22 ( 2 ) page： 301 - 304 2019.4
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Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants Reviewed
Niwa Yuri, Imai Kenji, Kotani Tomomi, Miki Rika, Nakano Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka
EARLY HUMAN DEVELOPMENT Vol. 129 page： 65 - 70 2019.2
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The role of E2F8 in the human placenta
Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi
MOLECULAR MEDICINE REPORTS Vol. 19 ( 1 ) page： 293 - 301 2019.1
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A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology
Sumigama Seiji, Enomoto Atsushi, Matsukawa Satoshi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 39 ( 4 ) page： 545 - 546 2019
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Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience
Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY Vol. 57 ( 6 ) page： 899 - 900 2018.12
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DRUG REPOSITIONING FOR SEARCH THE DRUG TO SUPPORT PLACENTAL GROWTH
Nomoto Masataka, Kotani Tomomi, Mizutani Teruyuki, Moriyama Yoshinori, Ushida Takefumi, Imai Kenji, Nakano Tomoko, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E21 - E21 2018.9
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THE RISK FOR PLACENTA ABRUPTION AMONG PREGNANT WOMEN WITH THYROID DISEASES
Kotani Tomomi, Nakano Tomoko, Imai Kenji, Moriyama Yoshinori, Nomoto Masataka, Mizutani Teruyuki, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E77 - E77 2018.9
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The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies
Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka
CLINICA CHIMICA ACTA Vol. 484 page： 293 - 297 2018.9
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The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies
Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka
CLINICA CHIMICA ACTA Vol. 484 page： 192 - 196 2018.9
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PLACENTAL PROTEOMIC ANALYSIS OF PLACENTA ACCRETA
Moriyama Yoshinori, Sumigama Seiji, Mizutani Teruyuki, Nomoto Masataka, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E74 - E75 2018.9
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PLACENTAL MORPHOLOGY AND PREGNANCY COMPLICATIONS IN FULLTERM PREGNANCY
Ushida Takafumi, Mizutani Teruyuki, Nomoto Masataka, Moriyama Yoshinori, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E76 - E76 2018.9
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EFFECTOR REGULATORY. CELLS IN THE DECIDUA DECREASE IN LABOR
Mizutani Teruyuki, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Moriyama Yoshinori, Nomoto Masataka, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E69 - E69 2018.9
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Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia
Moriyama Yoshinori, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Tsuda Hiroyuki, Kikkawa Fumitaka
SCHIZOPHRENIA RESEARCH Vol. 197 page： 615 - 617 2018.7
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Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model
Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka
SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 9221 2018.6
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Effect of molecular hydrogen on uterine inflammation during preterm labour
Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka
BIOMEDICAL REPORTS Vol. 8 ( 5 ) page： 454 - 460 2018.5
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Simulation training is useful for shortening the decision-to-delivery interval in cases of emergent cesarean section
Iitani Yukako, Tsuda Hiroyuki, Ito Yumiko, Moriyama Yoshinori, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Vol. 31 ( 23 ) page： 3128 - 3132 2018
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Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy
Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka
CLINICA CHIMICA ACTA Vol. 475 page： 70 - 77 2017.12
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Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)
Hirako Shima, Tsuda Hiroyuki, Ito Fumiya, Okazaki Yasumasa, Hirayama Tasuku, Nagasawa Hideko, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka, Toyokuni Shinya
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 61 ( 3 ) page： 176 - 182 2017.11
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A NOVEL APPROACH TO DETECTING POSTPARTUM HEMORRHAGE USING Reviewed
KENJI IMAI, TOMOMI KOTANI, HIROYUKI TSUDA, TOMOKO NAKANO, AKIHIRO HIRAKAWA, FUMITAKA KIKKAWA
Ultrasound in Medicine & Biology Vol. 43 ( 3 ) page： 615-620 2017.3
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A NOVEL APPROACH TO DETECTING POSTPARTUM HEMORRHAGE USING CONTRAST-ENHANCED ULTRASOUND
Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Hirakawa Akihiro, Kikkawa Fumitaka
ULTRASOUND IN MEDICINE AND BIOLOGY Vol. 43 ( 3 ) page： 615 - 620 2017.3
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A Novel Marker of Neonatal Respiratory Disorders: Umbilical 25-Hydroxyvitamin D (25(OH)D).
Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
REPRODUCTIVE SCIENCES Vol. 24 page： 282A - 282A 2017.3
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Observed-to-expected MRI fetal lung volume can predict long-term lung morbidity in infants with congenital diaphragmatic hernia
Tsuda Hiroyuki, Kotani Tomomi, Miura Mayo, Ito Yumiko, Hirako Shima, Nakano Tomoko, Imai Kenji, Kikkawa Fumitaka
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Vol. 30 ( 13 ) page： 1509 - 1513 2017
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Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia Reviewed
Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F.
Free Radic Biol Med. ( 91kikk ) page： 154-163 2016.2
Books 3
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周産期キーワード30 アップデート
今井健史（ Role： Contributor）
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周産期医学 51巻増刊号 周産期医学必修知識
今井健史（ Role： Contributor）
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現代の母性看護
今井健史（ Role： Contributor）
Presentations 3
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妊娠維持における母体腸内細菌水素産生能の重要性 -免疫細胞Th17/Tregおよび新規炎症性サイトカインIL-26に注目した検討- Invited
今井健史
第73回日本産科婦人科学会学術集会 2021.4.24
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妊娠維持における獲得免疫の関わり ～生体内分子状水素の役割を中心に～
今井健史、青木 智英子、水谷 輝之、小谷 友美、小林 知子、牛田 貴文、飯谷 友佳子、梶山 広明
第36回日本生殖免疫学会総会・学術集会 2021.10.30
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産後過多出血の管理向上を目指して ~産科領域におけるContrast-enhanced ultrasonography (CEUS)の臨床応用~
今井健史、小谷 友美、小林 知子、牛田 貴文、飯谷 友佳子、中村 紀友喜、梶山 広明
第1回日本超音波研究会学術集会 2022.1.30
KAKENHI (Grants-in-Aid for Scientific Research) 3
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早産減少を目指した新規管理法の検討～生体内水素産生能と免疫細胞Th17の関わり～
Grant number：21K16812 2021.4 - 2024.3
科学研究費助成事業 若手研究
今井 健史
Authorship：Principal investigator
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
正常な妊娠維持には適切な免疫寛容、Th17およびTregの適切なバランスが重要である。早産を含めたさまざまな疾病発症に関わるとされる腸内細菌叢はこれらTh17/Tregの分化誘導にも大きな影響を与える。また、腸内細菌叢は生体内における唯一の分子状水素産生源でもある。つまり、Th17/Treg、腸内細菌叢、分子状水素は互いに密接な関係にある。一方で、生理的に産生される分子状水素の生体内での役割、特にヒト妊婦における役割は未だ解明されていない。本研究の目的は分子状水素がヒトの妊娠免疫寛容にもたらす影響の検討およびヒト妊婦への分子状水素投与を実践に移すことである。
早産および胎児期に感染/炎症に曝された児は、脳性麻痺や慢性肺疾患など長期予後に大きな影響を及ぼすことが知られており、世界的な問題である。早産の予防や発症予測する試みは社会的要請度の高い課題である。
我々は兼ねてより早産や胎児脳障害に関する病態および炎症性サイトカインの関わりなどを研究してきた。これら知見をもとに、近年では分子状水素が抗酸化作用や抗炎症作用を有すること、分子量が小さいため拡散により胎盤や脳血液関門を容易に通過できる特性を持つことに注目し、妊娠予後の改善を図る新規管理法としての、生体内における生理的な分子状水素産生量が妊娠予後に与える影響、ならびに、経母体的分子状水素投与の有用性について研究している。
胎児は母体にとって半異物であり、正常な妊娠維持には適切な免疫寛容が必須である。免疫寛容の一端として、CD4陽性T細胞のsubtypeであるTh17およびTregの適切なバランスが重要とされる。早産を含めたさまざまな疾病発症に関わるとされる腸内細菌叢はこれらTh17/Tregの分化誘導にも大きな影響を与える。また、腸内細菌叢は生体内における唯一の分子状水素産生源でもある。つまり、Th17/Treg、腸内細菌叢、分子状水素は互いに密接な関係にある。
一方で、生理的に産生される分子状水素の生体内での役割、特にヒト妊婦における役割は未だ解明されていない。本研究の目的は分子状水素がヒトの妊娠免疫寛容にもたらす影響の検討およびヒト妊婦への分子状水素投与を実践に移すことである。
令和3年度に予定していた実験ならびに仮説の検証は順調に遂行し得た。
具体的には；
1）実験動物を用いた解析：Tcell活性化物質であるantiCD3投与の早産モデルマウスにおいて、飽和水素水の強制飲水および自由飲水の併用が早産予防効果を有するとの結果が得られた。一方で、antiCD3投与と同時に分子状水素を投与する治療効果の検証においては有意な差を示せなかった。
2）ヒト検体・情報を用いた解析：満期帝王切開症例を対象に無菌的にヒト羊膜・絨毛脱落膜を回収し組織培養。リコンビナントIL-26添加よりTNF-α、IL-6等のサイトカイン発現の有意な上昇を確認できた；健常人の末梢血単核球細胞を用いた実験においては予定していたTh17、Tregに加えてTh1細胞もフローサイトメトリーにて分離回収。antiCD3存在下に抗原提示細胞と共培養。分子状水素投与が各細胞の分化誘導やeffector化を抑制する働きを有するとの結果を得た。なお、当初の計画どおりにTh17はCD3+,CD4+,CCR6+,CXCR3-分画Th1はCD3+,CD4+,IFNγ+分画を持って、TregはCD3+,CD4+,Foxp3+分画を持って定義し、Th17のeffector化はIL26+orIL22+を、Tregのeffector化はFoxp3+hi&CD45RA-を持って定義した。
当初の仮説・推察のとおり、分子状水素がTh17の分化ならびにeffector化を修飾し、早産予防効果を発揮する可能性ことが分かった。次年度の研究では、免疫細胞や早産発生減少がどのような作用機序の元に起きるのかその解明に着手する。また、ヒト妊婦糞便/膣分泌物の回収ならびに16srRNA解析を実施し、ヒト腸内/膣内細菌叢と生体内H2濃度、Th17/Tregの関連を検討する。 -
Research on the effect of molecular hydrogen in pregnant women
Grant number：18K16765 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
IMAI Kenji
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
We first demonstrated the relationship of maternal hydrogen levels to immune cells and clinical PTB. Our findings suggested that there is a population of pregnant women with low hydrogen levels, and these women are divided into a high-risk group for PTB. In addition, we have shown that Th17, which is a negative factor for maternal immune tolerance, and Th17-producing inflammatory cytokine IL-26 could be suppressed by molecular hydrogen. Due to the ease and simplicity, measuring maternal hydrogen levels could be a potential clinical tool in the management of PTB. Moreover, supplementation of molecular hydrogen may be beneficial in the prevention of PTB.
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Preventative effects of molecular hydrogen on fetal brain injury
Grant number：16H06870 2016.8 - 2018.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up
Imai Kenji
Authorship：Principal investigator
Grant amount：\2730000 （ Direct Cost: \2100000 、 Indirect Cost：\630000 ）
It has been demonstrated that, in our maternal immunse activation (MIA) model mice, maternal administration of H2 attenuates oxidative damage and neuroinflammation in the fetal brain. In the present study, behavioral abilitiy were evaluated at postnatal 3 or 4 weeks. The number of neurons and oligodendrocytes was also analyzed at postnatal 5 weeks by immunohistochemical analysis. Offspring of the LPS-exposed dams showed deficits in short-term memory and social interaction, following neuronal and oligodendrocytic loss in the amygdala and cortex. Maternal H2 administration markedly attenuated these LPS-induced abnormalities. Moreover, the number of activated astrocytes was increased in LPS-exposed offspring, but decreased in the offspring of H2-administered dams. Overall, these findings indicate that maternal H2 administration exerts neuroprotective effects and ameliorates MIA-induced neurodevelopmental deficits of offspring later in life.
Teaching Experience (On-campus) 2
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Obstetrics Gynecology
2021
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Human Biology
2021