Updated on 2023/09/13

写真a

 
IMAI Kenji
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 医学博士 ( 2016.3   名古屋大学 ) 

Research Areas 1

  1. Life Science / Obstetrics and gynecology

Current Research Project and SDGs 1

  1. 早産病態の研究および新規治療戦略の探求

Awards 1

  1. 日本産科婦人科学会優秀演題賞

    2015.4   名古屋大学産婦人科  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 73

  1. New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan

    Ushida Takafumi, Nakamura Noriyuki, Katsuki Satoru, Mizutani Hidesuke, Iitani Yukako, Imai Kenji, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    HYPERTENSION RESEARCH     2023.7

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  2. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model

    Nakamura Noriyuki, Ushida Takafumi, Onoda Atsuto, Ueda Kazuto, Miura Ryosuke, Suzuki Toshihiko, Katsuki Satoru, Mizutani Hidesuke, Yoshida Kosuke, Tano Sho, Iitani Yukako, Imai Kenji, Hayakawa Masahiro, Kajiyama Hiroaki, Sato Yoshiaki, Kotani Tomomi

    FRONTIERS IN PEDIATRICS   Vol. 11   page: 1168173   2023.7

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  3. Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan

    Imai Kenji, Nozaki Yuki, Ushida Takafumi, Tano Sho, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 9 ) page: 2317 - 2323   2023.6

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  4. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants

    Nosaka Rena, Ushida Takafumi, Kidokoro Hiroyuki, Kawaguchi Masahiro, Shiraki Anna, Iitani Yukako, Imai Kenji, Nakamura Noriyuki, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2023.5

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  5. Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels

    Fuma Kazuya, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Iitani Yukako, Nakamura Noriyuki, Miki Rika, Katsuki Satoru, Kinoshita Fumie, Sato Yoshiaki, Hayakawa Masahiro, Kajiyama Hiroaki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH     2023.2

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  6. Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan

    Imai Kenji, Aoki Chieko, Tano Sho, Iitani Yukako, Nakamura Noriyuki, Ushida Takafumi, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH     2023.2

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  7. Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Iitani Yukako, Imai Kenji, Kinoshita Fumie, Kajiyama Hiroaki

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 21 ( 1 ) page: 7   2023.1

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  8. Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature

    Kotani Tomomi, Tsuda Hiroyuki, Ito Yumiko, Nakamura Noriyuki, Ushida Takafumi, Imai Kenji, Iitani Yukako, Fuma Kazuya, Muramatsu Yukako, Hayakawa Masahiro, Kajiyama Hiroaki

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 481   2022.12

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  9. Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning

    Ushida Takafumi, Kotani Tomomi, Baba Joji, Imai Kenji, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2022.12

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  10. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review

    Tano Sho, Kotani Tomomi, Yoshihara Masato, Nakamura Noriyuki, Matsuo Seiko, Ushida Takafumi, Imai Kenji, Ito Miharu, Oka Yasuyoshi, Sato Emi, Hayashi Shin, Ogi Tomoo, Kajiyama Hiroaki

    MOLECULAR GENETICS AND METABOLISM REPORTS   Vol. 33   page: 100925   2022.12

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  11. Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis

    Ushida Takafumi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Fuma Kazuya, Iitani Yukako, Imai Kenji, Sato Yoshiaki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi, Japan Neonatal Research Network Of

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2022.11

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  12. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells

    Aoki Chieko, Imai Kenji, Mizutani Teruyuki, Sugiyama Daisuke, Miki Rika, Koya Yoshihiro, Kobayashi Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Owaki Taro, Nishikawa Hiroyoshi, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi

    LIFE SCIENCES   Vol. 308   page: 120955   2022.11

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  13. 5p deletion with congenital diaphragmatic hernia: a case report

    Kotani Tomomi, Ushida Takafumi, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Tano Sho, Iwagaki Shigenori, Takahashi Yuichiro, Ito Miharu, Hayakawa Masahiro, Kajiyama Hiroaki

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 390   2022.10

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  14. Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 17502   2022.10

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  15. DEVELOPING OF A NOVEL THERAPEUTIC AGENT FOR FGR THROUGH DRUG REPOSITIONING

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Nakamura Noriyuki, Iitani Yukako, Yoshihara Masato, Imai Kenji, Kajiyama Hiroaki

    PLACENTA   Vol. 128   page: 124 - 124   2022.10

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  16. Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population

    Ushida Takafumi, Matsuo Seiko, Nakamura Noriyuki, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1760 - 1767   2022.7

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  17. Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants

    Ushida Takafumi, Kotani Tomomi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 28   page: 174 - 179   2022.6

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  18. The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia

    Aoki Chieko, Imai Kenji, Owaki Taro, Kobayashi-Nakano Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Kajiyama Hiroaki, Kotani Tomomi

    MEDICINA-LITHUANIA   Vol. 58 ( 6 )   2022.6

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  19. Machine learning prediction models for postpartum depression: A multicenter study in Japan

    Matsuo Seiko, Ushida Takafumi, Emoto Ryo, Moriyama Yoshinori, Iitani Yukako, Nakamura Noriyuki, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Matsui Shigeyuki, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH     2022.4

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  20. Pregnancy Outcomes in Women with Thyroid Diseases.

    Kotani T, Imai K, Ushida T, Moriyama Y, Nakano-Kobayashi T, Osuka S, Tsuda H, Sumigama S, Yamamoto E, Kinoshita F, Hirakawa A, Iwase A, Kikkawa F, Kajiyama H

    JMA journal   Vol. 5 ( 2 ) page: 216 - 223   2022.4

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    Language:English  

    DOI: 10.31662/jmaj.2021-0191

    PubMed

  21. Assessment of placental abruption with diffusion-weighted imaging

    Mizutani Teruyuki, Kotani Tomomi, Kato Noriko, Imai Kenji, Ushida Takafumi, Nakano-Kobayashi Tomoko, Kinoshita Yoshimi, Ito Masato, Kinoshita Fumie, Yamamuro Osamu, Kajiyama Hiroaki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 4 ) page: 930 - 937   2022.4

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  22. Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki

    FRONTIERS IN ENDOCRINOLOGY   Vol. 13   page: 815390   2022.3

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  23. Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan

    Matsuo Seiko, Ushida Takafumi, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 25 ( 1 ) page: 181 - 189   2022.2

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  24. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study

    Katsuki Satoru, Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Iitani Yukako, Fuma Kazuya, Imai Kenji, Nakano-Kobayashi Tomoko, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

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  25. Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan

    Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 26   page: 48 - 53   2021.12

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  26. Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 22519   2021.11

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  27. Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study

    Fujita Kei, Ushida Takafumi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Matsuo Seiko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 3867 - 3874   2021.11

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  28. Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction

    Nomoto Masataka, Kotani Tomomi, Miki Rika, Ushida Takafumi, Imai Kenji, Iitani Yukako, Tano Sho, Wang Jingwen, Moriyama Yoshinori, Kobayashi Tomoko, Mimura Nobuko, Iriyama Takayuki, Kikkawa Fumitaka, Kajiyama Hiroaki

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 69 ( 3 ) page: 280 - 285   2021.11

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  29. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia

    Miura Mayo, Imai Kenji, Tsuda Hiroyuki, Miki Rika, Tano Sho, Ito Yumiko, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Iitani Yukako, Nakano-Kobayashi Tomoko, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 17 )   2021.9

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  30. Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey

    Fujita Kei, Kotani Tomomi, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Kobayashi-Nakano Tomoko, Kato Noriko, Kano Takeo, Kikkawa Fumitaka, Kajiyama Hiroaki

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 18 ( 17 )   2021.9

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  31. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study

    Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Katsuki Satoru, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

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  32. Antenatal prediction models for short- and medium-term outcomes in preterm infants

    Ushida Takafumi, Moriyama Yoshinori, Nakatochi Masahiro, Kobayashi Yumiko, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   Vol. 100 ( 6 ) page: 1089 - 1096   2021.6

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  33. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders

    Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kinoshita Fumie, Nakamura Noriyuki, Iitani Yukako, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 24   page: 73 - 78   2021.6

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  34. Assessment of myocardial performance index in late-onset fetal growth restriction

    Tran Thao Nguyen Nguyen, Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Kobayashi Tomoko, Niimi Kaoru, Sumigama Seiji, Yamamoto Eiko, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 2 ) page: 259 - 268   2021.5

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  35. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis

    Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Hindmarch Charles C. T., Cotechini Tiziana, Imai Kenji, Nakano-Kobayashi Tomoko, Kajiyama Hiroaki, Graham Charles H.

    REPRODUCTION   Vol. 161 ( 5 ) page: 513 - 522   2021.5

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  36. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

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  37. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report

    Nakamura Noriyuki, Ushida Takafumi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Osuka Satoko, Goto Maki, Kajiyama Hiroaki, Asada Hideyuki, Hayakawa Masahiro, Kotani Tomomi

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

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  38. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study

    Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kikkawa Fumitaka

    SHOCK   Vol. 55 ( 3 ) page: 332 - 337   2021.3

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  39. Maternal low birth weight and hypertensive disorders of pregnancy

    Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

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  40. Liver transaminase levels during pregnancy: a Japanese multicenter study

    Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE     page: 1 - 7   2021.2

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  41. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage

    Owaki Taro, Imai Kenji, Miki Rika, Niwa Yuri, Kotani Tomomi, Nakano-Kobayashi Tomoko, Ushida Takafumi, Kajiyama Hiroaki

    CYTOKINE   Vol. 138   page: 155406   2021.2

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  42. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy Reviewed

    SCIENTIFIC REPORTS   Vol. 11 ( 1 )   2021.1

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  43. Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study

    Ushida Takafumi, Kotani Tomomi, Hayakawa Masahiro, Hirakawa Akihiro, Sadachi Ryo, Nakamura Noriyuki, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 9312   2020.6

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  44. Antenatal Corticosteroids and Outcomes in Preterm Twins Reviewed

    OBSTETRICS AND GYNECOLOGY   Vol. 135 ( 6 ) page: 1387 - 1397   2020.6

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  45. A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia.

    Tachi A, Moriyama Y, Tsuda H, Miki R, Ushida T, Miura M, Ito Y, Imai K, Nakano-Kobayashi T, Hayakawa M, Kikkawa F, Kotani T

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 345 - 354   2020.5

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    Language:English  

    DOI: 10.18999/nagjms.82.2.345

    PubMed

  46. Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings Reviewed

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Kobayashi Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka

      Vol. 127   2020.3

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1016/j.cyto.2019.154945

    Web of Science

  47. Adverse effects of endometriosis on pregnancy: a case-control study Reviewed

    Miura Mayo, Ushida Takafumi, Imai Kenji, Wang Jingwen, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Kikkawa Fumitaka, Kotani Tomomi

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 )   2019.10

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  48. A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases Reviewed

    Niwa Yuri, Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka

    JOURNAL OF CLINICAL ULTRASOUND   Vol. 47 ( 8 ) page: 494 - 496   2019.10

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    Language:English  

    DOI: 10.1002/jcu.22756

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  49. Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study. Reviewed

    Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 32 ( 16 ) page: 2633 - 2637   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14767058.2018.1443067

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    PubMed

  50. Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management Reviewed

    Imai Kenji, Kotani Tomomi, Ushida Takafumi, Moriyama Yoshinori, Nakano Tomoko, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 6 ) page: 757 - 762   2019.8

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    Authorship:Lead author   Language:English  

    DOI: 10.1080/01443615.2019.1581748

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  51. Somatic symptom disorder manifested as acute abdominal pain during pregnancy preceding perinatal depression: a case report

    Moriyama Yoshinori, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 22 ( 2 ) page: 301 - 304   2019.4

  52. Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants Reviewed

    Niwa Yuri, Imai Kenji, Kotani Tomomi, Miki Rika, Nakano Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka

    EARLY HUMAN DEVELOPMENT   Vol. 129   page: 65 - 70   2019.2

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1016/j.earlhumdev.2019.01.013

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  53. The role of E2F8 in the human placenta

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293 - 301   2019.1

  54. A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology

    Sumigama Seiji, Enomoto Atsushi, Matsukawa Satoshi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 4 ) page: 545 - 546   2019

  55. Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience

    Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 57 ( 6 ) page: 899 - 900   2018.12

  56. DRUG REPOSITIONING FOR SEARCH THE DRUG TO SUPPORT PLACENTAL GROWTH

    Nomoto Masataka, Kotani Tomomi, Mizutani Teruyuki, Moriyama Yoshinori, Ushida Takefumi, Imai Kenji, Nakano Tomoko, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E21 - E21   2018.9

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  57. THE RISK FOR PLACENTA ABRUPTION AMONG PREGNANT WOMEN WITH THYROID DISEASES

    Kotani Tomomi, Nakano Tomoko, Imai Kenji, Moriyama Yoshinori, Nomoto Masataka, Mizutani Teruyuki, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E77 - E77   2018.9

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  58. The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 293 - 297   2018.9

  59. The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 192 - 196   2018.9

  60. PLACENTAL PROTEOMIC ANALYSIS OF PLACENTA ACCRETA

    Moriyama Yoshinori, Sumigama Seiji, Mizutani Teruyuki, Nomoto Masataka, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E74 - E75   2018.9

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  61. PLACENTAL MORPHOLOGY AND PREGNANCY COMPLICATIONS IN FULLTERM PREGNANCY

    Ushida Takafumi, Mizutani Teruyuki, Nomoto Masataka, Moriyama Yoshinori, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E76 - E76   2018.9

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  62. EFFECTOR REGULATORY. CELLS IN THE DECIDUA DECREASE IN LABOR

    Mizutani Teruyuki, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Moriyama Yoshinori, Nomoto Masataka, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E69 - E69   2018.9

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  63. Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia

    Moriyama Yoshinori, Kotani Tomomi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Tsuda Hiroyuki, Kikkawa Fumitaka

    SCHIZOPHRENIA RESEARCH   Vol. 197   page: 615 - 617   2018.7

  64. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9221   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-27626-4

    Web of Science

    PubMed

  65. Effect of molecular hydrogen on uterine inflammation during preterm labour

    Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka

    BIOMEDICAL REPORTS   Vol. 8 ( 5 ) page: 454 - 460   2018.5

  66. Simulation training is useful for shortening the decision-to-delivery interval in cases of emergent cesarean section

    Iitani Yukako, Tsuda Hiroyuki, Ito Yumiko, Moriyama Yoshinori, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 31 ( 23 ) page: 3128 - 3132   2018

  67. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 475   page: 70 - 77   2017.12

  68. Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)

    Hirako Shima, Tsuda Hiroyuki, Ito Fumiya, Okazaki Yasumasa, Hirayama Tasuku, Nagasawa Hideko, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka, Toyokuni Shinya

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 61 ( 3 ) page: 176 - 182   2017.11

  69. A NOVEL APPROACH TO DETECTING POSTPARTUM HEMORRHAGE USING Reviewed

    KENJI IMAI, TOMOMI KOTANI, HIROYUKI TSUDA, TOMOKO NAKANO, AKIHIRO HIRAKAWA, FUMITAKA KIKKAWA

    Ultrasound in Medicine & Biology   Vol. 43 ( 3 ) page: 615-620   2017.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ultrasmedbio.2016.11.008.

  70. A NOVEL APPROACH TO DETECTING POSTPARTUM HEMORRHAGE USING CONTRAST-ENHANCED ULTRASOUND

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Hirakawa Akihiro, Kikkawa Fumitaka

    ULTRASOUND IN MEDICINE AND BIOLOGY   Vol. 43 ( 3 ) page: 615 - 620   2017.3

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  71. A Novel Marker of Neonatal Respiratory Disorders: Umbilical 25-Hydroxyvitamin D (25(OH)D).

    Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 282A - 282A   2017.3

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  72. Observed-to-expected MRI fetal lung volume can predict long-term lung morbidity in infants with congenital diaphragmatic hernia

    Tsuda Hiroyuki, Kotani Tomomi, Miura Mayo, Ito Yumiko, Hirako Shima, Nakano Tomoko, Imai Kenji, Kikkawa Fumitaka

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 30 ( 13 ) page: 1509 - 1513   2017

  73. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia Reviewed

    Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F.

    Free Radic Biol Med.   ( 91kikk ) page: 154-163   2016.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2015.12.015.

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Books 3

  1. 周産期キーワード30 アップデート

    今井健史( Role: Contributor)

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    Language:Japanese

  2. 周産期医学 51巻増刊号 周産期医学必修知識

    今井健史( Role: Contributor)

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    Language:Japanese

  3. 現代の母性看護

    今井健史( Role: Contributor)

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    Language:Japanese

Presentations 3

  1. 妊娠維持における母体腸内細菌水素産生能の重要性 -免疫細胞Th17/Tregおよび新規炎症性サイトカインIL-26に注目した検討- Invited

    今井健史

    第73回日本産科婦人科学会学術集会  2021.4.24 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  2. 妊娠維持における獲得免疫の関わり ~生体内分子状水素の役割を中心に~

    今井健史、青木 智英子、水谷 輝之、小谷 友美、小林 知子、牛田 貴文、飯谷 友佳子、梶山 広明

    第36回日本生殖免疫学会総会・学術集会  2021.10.30 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  3. 産後過多出血の管理向上を目指して ~産科領域におけるContrast-enhanced ultrasonography (CEUS)の臨床応用~

    今井健史、小谷 友美、小林 知子、牛田 貴文、飯谷 友佳子、中村 紀友喜、梶山 広明

    第1回日本超音波研究会学術集会  2022.1.30 

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    Event date: 2022.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 早産減少を目指した新規管理法の検討~生体内水素産生能と免疫細胞Th17の関わり~

    Grant number:21K16812  2021.4 - 2024.3

    科学研究費助成事業  若手研究

    今井 健史

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    正常な妊娠維持には適切な免疫寛容、Th17およびTregの適切なバランスが重要である。早産を含めたさまざまな疾病発症に関わるとされる腸内細菌叢はこれらTh17/Tregの分化誘導にも大きな影響を与える。また、腸内細菌叢は生体内における唯一の分子状水素産生源でもある。つまり、Th17/Treg、腸内細菌叢、分子状水素は互いに密接な関係にある。一方で、生理的に産生される分子状水素の生体内での役割、特にヒト妊婦における役割は未だ解明されていない。本研究の目的は分子状水素がヒトの妊娠免疫寛容にもたらす影響の検討およびヒト妊婦への分子状水素投与を実践に移すことである。
    早産および胎児期に感染/炎症に曝された児は、脳性麻痺や慢性肺疾患など長期予後に大きな影響を及ぼすことが知られており、世界的な問題である。早産の予防や発症予測する試みは社会的要請度の高い課題である。
    我々は兼ねてより早産や胎児脳障害に関する病態および炎症性サイトカインの関わりなどを研究してきた。これら知見をもとに、近年では分子状水素が抗酸化作用や抗炎症作用を有すること、分子量が小さいため拡散により胎盤や脳血液関門を容易に通過できる特性を持つことに注目し、妊娠予後の改善を図る新規管理法としての、生体内における生理的な分子状水素産生量が妊娠予後に与える影響、ならびに、経母体的分子状水素投与の有用性について研究している。
    胎児は母体にとって半異物であり、正常な妊娠維持には適切な免疫寛容が必須である。免疫寛容の一端として、CD4陽性T細胞のsubtypeであるTh17およびTregの適切なバランスが重要とされる。早産を含めたさまざまな疾病発症に関わるとされる腸内細菌叢はこれらTh17/Tregの分化誘導にも大きな影響を与える。また、腸内細菌叢は生体内における唯一の分子状水素産生源でもある。つまり、Th17/Treg、腸内細菌叢、分子状水素は互いに密接な関係にある。
    一方で、生理的に産生される分子状水素の生体内での役割、特にヒト妊婦における役割は未だ解明されていない。本研究の目的は分子状水素がヒトの妊娠免疫寛容にもたらす影響の検討およびヒト妊婦への分子状水素投与を実践に移すことである。
    令和3年度に予定していた実験ならびに仮説の検証は順調に遂行し得た。
    具体的には;
    1)実験動物を用いた解析:Tcell活性化物質であるantiCD3投与の早産モデルマウスにおいて、飽和水素水の強制飲水および自由飲水の併用が早産予防効果を有するとの結果が得られた。一方で、antiCD3投与と同時に分子状水素を投与する治療効果の検証においては有意な差を示せなかった。
    2)ヒト検体・情報を用いた解析:満期帝王切開症例を対象に無菌的にヒト羊膜・絨毛脱落膜を回収し組織培養。リコンビナントIL-26添加よりTNF-α、IL-6等のサイトカイン発現の有意な上昇を確認できた;健常人の末梢血単核球細胞を用いた実験においては予定していたTh17、Tregに加えてTh1細胞もフローサイトメトリーにて分離回収。antiCD3存在下に抗原提示細胞と共培養。分子状水素投与が各細胞の分化誘導やeffector化を抑制する働きを有するとの結果を得た。なお、当初の計画どおりにTh17はCD3+,CD4+,CCR6+,CXCR3-分画Th1はCD3+,CD4+,IFNγ+分画を持って、TregはCD3+,CD4+,Foxp3+分画を持って定義し、Th17のeffector化はIL26+orIL22+を、Tregのeffector化はFoxp3+hi&CD45RA-を持って定義した。
    当初の仮説・推察のとおり、分子状水素がTh17の分化ならびにeffector化を修飾し、早産予防効果を発揮する可能性ことが分かった。次年度の研究では、免疫細胞や早産発生減少がどのような作用機序の元に起きるのかその解明に着手する。また、ヒト妊婦糞便/膣分泌物の回収ならびに16srRNA解析を実施し、ヒト腸内/膣内細菌叢と生体内H2濃度、Th17/Tregの関連を検討する。

  2. Research on the effect of molecular hydrogen in pregnant women

    Grant number:18K16765  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    IMAI Kenji

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    We first demonstrated the relationship of maternal hydrogen levels to immune cells and clinical PTB. Our findings suggested that there is a population of pregnant women with low hydrogen levels, and these women are divided into a high-risk group for PTB. In addition, we have shown that Th17, which is a negative factor for maternal immune tolerance, and Th17-producing inflammatory cytokine IL-26 could be suppressed by molecular hydrogen. Due to the ease and simplicity, measuring maternal hydrogen levels could be a potential clinical tool in the management of PTB. Moreover, supplementation of molecular hydrogen may be beneficial in the prevention of PTB.

  3. Preventative effects of molecular hydrogen on fetal brain injury

    Grant number:16H06870  2016.8 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity Start-up

    Imai Kenji

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    Grant amount:\2730000 ( Direct Cost: \2100000 、 Indirect Cost:\630000 )

    It has been demonstrated that, in our maternal immunse activation (MIA) model mice, maternal administration of H2 attenuates oxidative damage and neuroinflammation in the fetal brain. In the present study, behavioral abilitiy were evaluated at postnatal 3 or 4 weeks. The number of neurons and oligodendrocytes was also analyzed at postnatal 5 weeks by immunohistochemical analysis. Offspring of the LPS-exposed dams showed deficits in short-term memory and social interaction, following neuronal and oligodendrocytic loss in the amygdala and cortex. Maternal H2 administration markedly attenuated these LPS-induced abnormalities. Moreover, the number of activated astrocytes was increased in LPS-exposed offspring, but decreased in the offspring of H2-administered dams. Overall, these findings indicate that maternal H2 administration exerts neuroprotective effects and ameliorates MIA-induced neurodevelopmental deficits of offspring later in life.

 

Teaching Experience (On-campus) 2

  1. Obstetrics Gynecology

    2021

  2. Human Biology

    2021