Organization
Graduate School of Medicine Designated lecturer
Title
Designated lecturer
KATAOKA Naoya
Degree 1
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博士（農学） （ 2009.3 鳥取大学 ）
Research Interests 4
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sympathetic nerve
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hyperthermia
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Brown adipose tissue thermogenesis
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psychological stress
Research History 1
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Nagoya University Designated lecturer
2020.5
Country：Japan
Awards 1
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第22回 日本生理学会奨励賞
2021.3 日本生理学会
Papers 14
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Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling
Nakamura Yoshiko, Yahiro Takaki, Fukushima Akihiro, Kataoka Naoya, Hioki Hiroyuki, Nakamura Kazuhiro
SCIENCE ADVANCES Vol. 8 ( 51 ) page： eadd5463 2022.12
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An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow
Fukushima Akihiro, Kataoka Naoya, Nakamura Kazuhiro
CELL REPORTS Vol. 40 ( 12 ) page： 111380 2022.9
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A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses
Koba Satoshi, Kumada Nao, Narai Emi, Kataoka Naoya, Nakamura Kazuhiro, Watanabe Tatsuo
NATURE COMMUNICATIONS Vol. 13 ( 1 ) page： 5079 2022.8
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A hypothalamomedullary network for physiological responses to environmental stresses
Nakamura Kazuhiro, Nakamura Yoshiko, Kataoka Naoya
NATURE REVIEWS NEUROSCIENCE Vol. 23 ( 1 ) page： 35 - 52 2022.1
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Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever
Yoneshiro Takeshi, Kataoka Naoya, Walejko Jacquelyn M., Ikeda Kenji, Brown Zachary, Yoneshiro Momoko, Crown Scott B., Osawa Tsuyoshi, Sakai Juro, McGarrah Robert W., White Phillip J., Nakamura Kazuhiro, Kajimura Shingo
ELIFE Vol. 10 2021.5
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Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice
Kataoka Naoya, Takeuchi Tamaki, Kusudo Tatsuya, Li Yongxue, Endo Yuki, Yamashita Hitoshi
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Vol. 1866 ( 7 ) page： 165762 2020.7
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A central master driver of psychosocial stress responses in the rat
Kataoka Naoya, Shima Yuta, Nakajima Keisuke, Nakamura Kazuhiro
SCIENCE Vol. 367 ( 6482 ) page： 1105 - + 2020.3
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CREG1 stimulates brown adipocyte formation and ameliorates diet-induced obesity in mice
Hashimoto Michihiro, Kusudo Tatsuya, Takeuchi Tamaki, Kataoka Naoya, Mukai Takako, Yamashita Hitoshi
FASEB JOURNAL Vol. 33 ( 7 ) page： 8069 - 8082 2019.7
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CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro
Kusudo Tatsuya, Hashimoto Michihiro, Kataoka Naoya, Li Yongxue, Nozaki Aya, Yamashita Hitoshi
JOURNAL OF BIOCHEMISTRY Vol. 165 ( 1 ) page： 47 - 55 2019.1
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Sympathoexcitation by hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla
Koba Satoshi, Hanai Eri, Kumada Nao, Kataoka Naoya, Nakamura Kazuhiro, Watanabe Tatsuo
JOURNAL OF PHYSIOLOGY-LONDON Vol. 596 ( 19 ) page： 4581 - 4595 2018.10
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The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation
Yahiro Takaki, Kataoka Naoya, Nakamura Yoshiko, Nakamura Kazuhiro
SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 5031 2017.7
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A ventral medial prefrontal cortex-dorsomedial hypothalamus monosynaptic pathway that drives sympathetic stress responses
Kataoka Naoya, Nakamura Kazuhiro
FASEB JOURNAL Vol. 31 2017.4
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Optogenetic stimulation of PVN-RVLM neurons increases sympathetic nerve activity in anesthetized rats
Koba Satoshi, Hanai Eri, Kumada Nao, Kataoka Naoya, Nakamura Kazuhiro, Watanabe Tatsuo
FASEB JOURNAL Vol. 31 2017.4
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Determination of thermosensory pathways required for behavioural thermoregulation
Yahiro Takaki, Kataoka Naoya, Nakamura Yoshiko, Nakamura Kazuhiro
FASEB JOURNAL Vol. 31 2017.4
KAKENHI (Grants-in-Aid for Scientific Research) 3
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様々なストレス関連疾患の原因となるストレスホルモンの分泌制御機構解明
Grant number：22K06470 2022.4 - 2025.3
科学研究費助成事業 基盤研究(C)
片岡 直也
Authorship：Principal investigator
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
ストレスホルモン分泌を担うCRHニューロンが存在する PVHへストレス信号を入力する神経路は様々な報告がある。さらに、様々な環境刺激によって変化する血中ストレスホルモン濃度の分泌制御を担う中枢神経メカニズムも明らかになっていない。本研究では、PVHより上位に位置する複数の神経核が複雑な神経ネットワークを形成し、相互に神経活動のバランスを制御することでストレスホルモン分泌の強弱を決定すると仮説をたてた。この仮説を検証するため神経ネットワークのバランスを捉えるマルチファイバフォトメトリを駆使し、ストレスホルモン分泌と神経伝達路の活動相関をから、ストレスホルモン分泌制御機構の全容解明を目指す。
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Grant number：19K06954 2019.4 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
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Elucidation of stress-induced hyperthermic mechanism by recall of stress emotional memory
Grant number：16K19006 2016.4 - 2019.3
Kataoka Naoya
Authorship：Principal investigator
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
Strong psychological stress is stored in the amygdala as "emotional memory". In particular, negative emotional memory, when recalled by conditional stimuli such as sounds and places, causes stress reactions such as palpitations and temperature elevations, and also causes acute stress disorder and trauma stress syndrome. I found a physiological response in which rats suffering from social defeat stress are enhanced in brown adipose thermogenesis at the same time despite the fact that they are not stressed from the next day onwards, and their temperature rises. I think that this reaction is caused as a result of recalling psychological stress memory. The research plan will clarify the neural circuits of the brain that drive this recalled stress-induced thermogenesis response. In order to accomplish this purpose, we will use optogenetics techniques to elucidate the neural circuit from the amygdala to the dorsomedial hypothalamus region that causes stress-induced thermogenesis.
Teaching Experience (On-campus) 3
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基礎医学セミナー
2022
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生体の機能II・本能行動「ストレス」
2022
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後期基礎セミナー「Meet the authors」
2021