Updated on 2023/07/19

写真a

 
MAEDA Keiko
 
Organization
Nagoya University Hospital Gastroenterology Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor

Degree 1

  1. 博士(医学) ( 2018.4   名古屋大学 ) 

Research Areas 2

  1. Life Science / Gastroenterology

  2. Life Science / Gastroenterology

Research History 2

  1. 名古屋大学医学部附属病院

    2018.4

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    Country:Japan

  2. Boston Children's Hospital

    2016.6 - 2018.3

Professional Memberships 3

  1. 日本内科学会

  2. 日本消化器内視鏡学会

  3. 日本消化器病学会

Awards 4

  1. 日本炎症性腸疾患学会-アッヴィ研究奨励賞

    2023.2   日本炎症性腸疾患学会  

  2. 令和4年度 医学系研究科医学奨励賞 最優秀賞

    2023.1   名古屋大学  

  3. Early career investigator award

    2018.6  

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  4. Poster of distinction award

    2017.5  

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    Award type:International academic award (Japan or overseas)  Country:United States

 

Papers 46

  1. 特集 消化管内視鏡治療のリスク克服に向けて 1.待機的内視鏡治療に潜むリスクとそのマネジメント(6)大腸EMR/ESD

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 古川 和宏, 川嶋 啓揮

    臨床消化器内科   Vol. 38 ( 1 ) page: 42 - 47   2022.12

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    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000002478

    CiNii Research

  2. The effects of ustekinumab on small intestinal lesions and stenotic lesions

    Wada Hirotaka, Murate Kentaro, Nakamura Masanao, Furukawa Kazuhiro, Kakushima Naomi, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Nakayama Goro, Hattori Norifumi, Umeda Shinichi, Ishigami Masatoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 4 ) page: 825 - 838   2022.11

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    Language:English   Publisher:Nagoya Journal of Medical Science  

    Crohn’s disease patients suffer from symptoms originating from small bowel lesions, including strictures. As many of these patients also have a potential risk of surgery, it is important to consider various therapeutic strategies for small bowel lesions. We retrospectively analyzed the therapeutic effects of ustekinumab, interleukin-12 and -23 blocker, for small intestinal lesions and intestinal stenosis in order to contribute to the optimal management of Crohn’s disease. Patients who underwent total colonoscopy or small bowel endoscopy before and after the introduction of ustekinumab were enrolled in this study. The colonoscopy findings were evaluated by the simple endoscopic score for Crohn’s disease, and small bowel endoscopy findings were evaluated using the modified simple endoscopic score for Crohn’s disease. Endoscopic scores were compared before and after the introduction of ustekinumab and between the responders and non-responders to ustekinumab. Responders were defined as those whose Crohn’s disease activity index score at 24 weeks fell below 150 points, or those whose score decreased by more than 100 points from the pre-induction level. A total of 50 patients were enrolled in the study, and the number of responders was 35. Pre-induction simple endoscopic scores were lower for responders, but no significant difference was observed in the modified simple endoscopic scores. The total decrease in the endoscopic score was significantly higher in the responders for both the small and large intestine. Use of ustekinumab as a first-line treatment for patients with small bowel lesions or stricture-prone lesions may be a new treatment consideration in the future.

    DOI: 10.18999/nagjms.84.4.825

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  3. 今月の主題 炎症性腸疾患の粘膜治癒を再考する 主題 Crohn病における小腸粘膜治癒評価の意義-小腸カプセル内視鏡の立場から

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 石川 恵里, 角嶋 直美, 古川 和宏, 飯田 忠, 水谷 泰之, 石川 卓哉, 大野 栄三郎, 川嶋 啓揮, 藤城 光弘

    胃と腸   Vol. 57 ( 2 ) page: 183 - 189   2022.2

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403202660

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  4. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients. International journal

    Masanao Nakamura, Keiko Maeda, Kenta Yamamoto, Takeshi Yamamura, Tsunaki Sawada, Eri Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Tadashi Iida, Yasuyuki Mizutani, Takuya Ishikawa, Eizaburo Ohno, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima

    Digestion   Vol. 103 ( 3 ) page: 232 - 243   2022

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    Language:English  

    BACKGROUND: The pathophysiology of ulcerative colitis (UC) remains unclear, but early lesions on the colorectal mucosal surface may play an important role in its etiology. Intestinal mucus samples, including inner and outer layers, are collected by net or brush catheters, but the quality of the samples obtained by each method has not been fully investigated. OBJECTIVE: The purpose of this study was to compare the microbiome and protein content of intestinal mucus collected by net and brush catheters during colonoscopy. METHODS: Intestinal mucus samples from the lower rectum of 4 patients with UC were collected using a net catheter, a brush catheter, and intestinal fluid suction. Microbiome and protein content were analyzed using 16S rRNA gene sequencing and mass spectrometry. RESULTS: The patients demonstrated significant differences in microbiome alpha diversity (p < 0.05), but this difference was not observed between the sampling methods. Net catheter samples demonstrated higher total protein concentrations than brush catheter samples. The brush catheter group had more Lachnospira, a butyrate-producing bacterium, when compared to the net group. The brush catheter group also had more oral bacteria of Staphylococcus and Dialister in those with active phase when compared to the net group. CONCLUSIONS: Brush catheters are more likely to collect the intestinal mucus inner layer, whereas net catheters are more likely to collect larger samples that include the outer mucus layer, as well as the intestinal fluid. Two sampling methods with different types of collection of the mucosa may lead to different results among patients with mucosal vulnerabilities.

    DOI: 10.1159/000521929

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  5. 小腸Dieulafoy病変(矢野-山本分類Type 2a)の診断と治療についての臨床的検討

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 石川 恵里, 川嶋 啓揮

    日本小腸学会学術集会プログラム・抄録集   Vol. 6 ( 0 ) page: 65 - 65   2022

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    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景】小腸Dieulafoy病変は、内視鏡観察時に自然止血されている可能性があるため確定診断と治療が遅れる傾向を有する。一方では、Dieulafoy病変の臨床的特徴を把握しておくことによって診断のタイミングや治療戦略を事前に検討できるかもしれない。本研究の目的は、当院で経験された同病変の臨床的特徴を後方視的に調査し、その最適な診断と治療につき検討することであった。</p><p>【対象・方法】対象は当院において2003年6月から2022年7月の間に小腸出血が疑われダブルバルーン内視鏡(以下DBE)を施行し、Dieulafoy病変と診断、内視鏡治療を受けた36例であった。本研究におけるDieulafoy病変の定義は、粘膜面の変化は露出血管部のみとし、付着する血栓を認める場合と露出血管からの噴出性かそれに準じる活動性出血を認める場合とした。臨床的背景、治療方法などを検討した。</p><p>【結果】男性/女性は19/17例、平均年齢は71±10歳であった。33例でなんらかの基礎疾患を有していた。抗血栓薬の使用を19例で認め、ワーファリン10例、バイアスピリン7例(重複あり)の順で多かった。累計の出血エピソードは中央値で2回(1-18回)であった。最低血中ヘモグロビン値は5.9±1.7g/dl、赤血球輸血は2例以外の全例で行われていた。症状発現からDBEまでは中央値18日(2-63日)であった。DBE時の所見について、病変部位は深部十二指腸、上部空腸、中部空腸、下部空腸、中部回腸、下部回腸で各々3、18、8、2、2,6例で認められた(重複あり)。治療はクリッピング34例、APC凝固2例であった。偶発症は再出血10例(27.7%)、急性膵炎1例であった。</p><p>【結語】小腸Dieulafoy病変は診断に苦慮し、治療までに時間と輸血処置などを多く要していた。本病変が疑われた際には早めの内視鏡検査が検討される。</p>

    DOI: 10.32264/shocho.6.0_65

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  6. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching. International journal

    Masashi Saito, Takeshi Yamamura, Masanao Nakamura, Keiko Maeda, Tsunaki Sawada, Eri Ishikawa, Yasuyuki Mizutani, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Hiroki Kawashima, Masatoshi Ishigami, Mitsuhiro Fujishiro

    World journal of gastroenterology   Vol. 27 ( 47 ) page: 8182 - 8193   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Cold polypectomy (CP) is a simple and safe procedure for polyps less than 10 mm in size; however, there is concern about local recurrence following CP because of unidentified margins of excised specimens and the lack of tumor suppression effect by coagulation. Some clinical trials have evaluated local persistent recurrence; their results suggest that a higher rate of local recurrence has not been documented so far. There were few reports that observed the course over long periods of time after CP in clinical practice. AIM: To evaluate the presence of local recurrence following CP and hot polypectomy (HP) using propensity score matching. METHODS: We analyzed 275 patients who underwent polypectomy for non-pedunculated colorectal polyps less than 10 mm (959 Lesions) between October 2016 and 2017 and underwent follow-up endoscopy subsequently. We divided them into the CP group (706 Lesions), wherein CP was performed, and the HP group (253 Lesions), wherein HP was performed. Using propensity score matching, we extracted 215 Lesions in each group and evaluated the local recurrence and content of CP in the real clinic and adverse events using medical records. RESULTS: After propensity score matching, there were no significant differences in the patients' and their endoscopic background (age, use of antithrombotics, indications, size, morphology, location of polyps, and polypectomy device) between the groups. The mean duration between colorectal polypectomy and the next follow-up colonoscopy was 17.5 ± 7.1 (range, 6-39) mo in the CP group and 15.7 ± 6.0 (range, 6-35) mo in the HP group, which was significantly longer in the CP group (P = 0.005). The local recurrence rate was 0.93% in the CP group and 0.93% in the HP group, without a significant difference (P = 0.688). Additionally, no differences were observed in the macroscopic en bloc resection rate, histopathological complete resection rate, and pathological results between the groups. Adverse events did not occur in either group. CONCLUSION: Local recurrence after CP was equivalent to that following HP in clinical practice. CP is useful and safe in the treatment of non-pedunculated polyps of less than 10 mm.

    DOI: 10.3748/wjg.v27.i47.8182

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  7. 特集 Cold polypectomyの課題 4.症例からみえた課題(1)小腸ポリープに対するcold polypectomy

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 角嶋 直美, 古川 和宏, 川嶋 啓揮

    臨床消化器内科   Vol. 37 ( 1 ) page: 93 - 96   2021.12

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    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000002065

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  8. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 )   2021.2

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    Publisher:BMC Gastroenterology  

    DOI: 10.1186/s12876-021-01657-0

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  9. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports

    Murate Kentaro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 14 ( 1 ) page: 129 - 135   2021.2

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    Publisher:Clinical Journal of Gastroenterology  

    DOI: 10.1007/s12328-020-01242-0

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  10. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables

    Ishikawa Eri, Nakaguro Masato, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Maeda Keiko, Furukawa Kazuhiro, Shimoyama Yoshie, Kawashima Hiroki, Fujishiro Mitsuhiro

    PATHOLOGY INTERNATIONAL   Vol. 71 ( 1 ) page: 33 - 41   2021.1

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    Publisher:Pathology International  

    DOI: 10.1111/pin.13048

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  11. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease

    Hattori Shun, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Yamamoto Kenta, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   Vol. 55 ( 12 ) page: 1138 - 1149   2020.12

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    Publisher:Journal of Gastroenterology  

    DOI: 10.1007/s00535-020-01728-1

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  12. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Suzuki Hiroto, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTION     2020.11

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    Publisher:Digestion  

    DOI: 10.1159/000511589

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  13. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

    Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 26 ( 42 ) page: 6669 - 6678   2020.11

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    Publisher:World Journal of Gastroenterology  

    DOI: 10.3748/wjg.v26.i42.6669

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  14. Endoscopic Activity and Serum TNF-alpha Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients

    Murate Kentaro, Maeda Keiko, Nakamura Masanao, Sugiyama Daisuke, Wada Hirotaka, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Miyahara Ryoji, Ishigami Masatoshi, Nishikawa Hiroyoshi, Fujishiro Mitsuhiro

    INFLAMMATORY BOWEL DISEASES   Vol. 26 ( 11 ) page: 1669 - 1681   2020.11

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    Publisher:Inflammatory Bowel Diseases  

    DOI: 10.1093/ibd/izaa086

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  15. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration

    Funasaka Kohei, Miyahara Ryoji, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Hirooka Yoshiki, Ohmiya Naoki, Fujishiro Mitsuhiro

    TRANSLATIONAL ONCOLOGY   Vol. 13 ( 11 )   2020.11

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    Publisher:Translational Oncology  

    DOI: 10.1016/j.tranon.2020.100848

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  16. New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Furukawa Kazuhiro, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE     2020.10

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    Publisher:International Journal of Colorectal Disease  

    DOI: 10.1007/s00384-020-03790-w

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  17. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2020.9

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    Publisher:Surgical Endoscopy  

    DOI: 10.1007/s00464-020-07936-3

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  18. 診断に苦慮した広範囲胆管癌の1例

    芳川 昌功, 川嶋 啓揮, 大野 栄三郎, 石川 卓哉, 小屋 敏也, 田中 浩敬, 酒井 大輔, 飯田 忠, 西尾 亮, 鈴木 博貴, 植月 康太, 八鹿 潤, 山田 健太, 澤田 つな騎, 前田 啓子, 山村 健史, 古川 和宏, 舩坂 好平, 中村 正直, 宮原 良二, 廣岡 芳樹

    肝胆膵治療研究会誌   Vol. 16 ( 1 ) page: 93 - 93   2020.9

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    Language:Japanese   Publisher:肝胆膵治療研究会  

  19. 特集 クローン病小腸狭窄病変に対する内視鏡的バルーン拡張術─基本からピットフォールまで Ⅱ.クローン病小腸狭窄病変に対するバルーン拡張術(4)クローン病におけるバルーン拡張術のコツ a.ダブルバルーン内視鏡の立場から

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 恵里, 古川 和宏, 角嶋  直美, 藤城 光弘

    INTESTINE   Vol. 24 ( 3 ) page: 197 - 202   2020.8

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    Publisher:日本メディカルセンター  

    DOI: 10.19020/int.0000000486

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  20. 特集 分子標的時代のIBD 診療 -IBD の寛解導入,寛解維持の実践 3.IBD 治療における寛解導入と寛解維持に関するトピック(5)UC 関連腫瘍の早期診断と治療

    山村 健史, 中村 正直, 前田 啓子, 澤田 つな騎, 石川 恵里, 喜田 裕一, 古川 和宏, 川嶋 啓揮, 藤城 光弘

    臨床消化器内科   Vol. 35 ( 10 ) page: 1267 - 1273   2020.8

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    Publisher:日本メディカルセンター  

    DOI: 10.19020/cg.0000001325

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  21. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure.

    Muroi K, Kakushima N, Furukawa K, Ishikawa E, Sawada T, Ishikawa T, Maeda K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Funasaka K, Miyahara R, Fujishiro M

    Digestive diseases and sciences     2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-020-06527-5

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  22. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice.

    Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M

    Digestive diseases and sciences     2020.6

  23. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Hirooka Yoshiki

    DIGESTION   Vol. 101 ( 3 ) page: 316-322   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000498942

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  24. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study.

    Nishio R, Kawashima H, Nakamura M, Ohno E, Ishikawa T, Yamamura T, Maeda K, Sawada T, Tanaka H, Sakai D, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M

    World journal of gastroenterology   Vol. 26 ( 10 ) page: 1056 - 1066   2020.3

  25. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis.

    Ishikawa T, Kawashima H, Ohno E, Tanaka H, Maeda K, Sawada T, Yamamura T, Furukawa K, Nakamura M, Miyahara R, Ishigami M, Fujishiro M

    Pancreas   Vol. 49 ( 2 ) page: E21 - E22   2020.2

  26. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma

    Kobayashi Kenichi, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakaguro Masato, Okumura Yuki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   Vol. 32 ( 1 ) page: 65 - 73   2020.1

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    Publisher:Digestive Endoscopy  

    DOI: 10.1111/den.13469

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  27. A Case of Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis.

    Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ohashi A, Kajikawa G, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 23 ) page: 3009 - 3014   2020

  28. Comparison of high-resolution manometry in patients complaining of dysphagia among patients with or without diabetes mellitus

    Muroi K.

    Digestion     2020

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    Publisher:Digestion  

    DOI: 10.1159/000510081

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  29. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope.

    Suzuki H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 15 ) page: 1795 - 1801   2020

  30. 単発性小腸Peutz-Jeghers型ポリープに関する臨床的検討

    鳥山 和浩, 中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 恵里, 梶川 豪, 村手 健太郎, 喜田 裕一, 江崎 正哉, 濱崎 元伸, 角嶋 直美, 古川 和宏, 藤城 光弘

    日本小腸学会学術集会プログラム・抄録集   Vol. 4 ( 0 ) page: 39 - 39   2020

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    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景】Peutz-Jeghers症候群(PJS)は食道を除く全消化管において上皮の過形成と粘膜筋板のポリープ内への樹枝状増生を特徴とする過誤腫性ポリポーシスと皮膚、粘膜の色素斑を特徴とする常染色体優性遺伝性疾患である。一方、家族歴や皮膚、粘膜の色素沈着を伴わない単発性のPeutz-Jeghers型ポリープ(PJP)を認めることがあるが、その臨床的特徴に関する報告は少ないのが現状である。</p><p>【目的】単発性小腸PJPにおける臨床的特徴を明らかにする。</p><p>【対象】2007年4月から2020年5月までに当院で内視鏡治療を施行し、病理組織学的にPJPと診断された単発性小腸PJP16症例。</p><p>【結果】レトロスペクティブにカルテ、内視鏡画像をレビューした。性別は男性10例、女性6例、診断時年齢中央値(範囲)は61(18-82)歳。診断契機は貧血7例、黒色便5例、腹痛1例、イレウス症状1例、他疾患精査時の偶発的発見が2例。原発部位は空腸14例、回腸2例で、腫瘍径中央値(範囲)は25(4-35)mm。切除したPJP全病変で病変内に悪性腫瘍の併存は認めなかった。癌の既往歴を有したのは6例(前立腺癌2例、舌癌1例、大腸癌1例、胃癌1例、子宮体癌1例)。観察期間中央値(範囲)は4.6(0.1-53.7)ヶ月で再発並びに関連死は認めなかった。</p><p>【考察】単発性小腸PJPにおいては診断時の年齢が高く、発見契機としては出血関連症状が多く、病変部位は空腸に多い特徴があった。</p><p>【結語】当院で経験した単発性小腸PJPの臨床的特徴を検討した。今後更なる症例の蓄積が必要である。</p>

    DOI: 10.32264/shocho.4.0_39

    CiNii Research

  31. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 34   page: 152 - 152   2019.9

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  32. Roles of the mesenchymal stromal/stem cell marker meflin in cardiac tissue repair and the development of diastolic dysfunction

    Hara A.

    Circulation Research   Vol. 125 ( 4 ) page: 414 - 430   2019.8

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    Publisher:Circulation Research  

    DOI: 10.1161/CIRCRESAHA.119.314806

    Scopus

  33. USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA Reviewed International journal

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Suzuki Hiroto, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   Vol. 89 ( 6 ) page: AB324 - AB324   2019.6

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  34. ダブルバルーン小腸内視鏡を用いた硬化療法にて治療効果を得た小腸多発血管腫の1例

    山田 啓策, 山村 健史, 中村 正直, 澤田 つな騎, 水谷 泰之, 前田 啓子, 古川 和宏, 宮原 良二, 横井 太紀雄, 廣岡 芳樹

    Gastroenterological Endoscopy   Vol. 61 ( 6 ) page: 1231 - 1236   2019.6

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    Language:Japanese   Publisher:(一社)日本消化器内視鏡学会  

    70歳代男性。1ヵ月間持続する黒色便にて当科紹介となった。上下部消化管内視鏡検査では、明らかな出血源を認めなかった。小腸出血を疑いカプセル内視鏡検査を施行したところ、全小腸にわたり多発する隆起性病変を認めた。ダブルバルーン小腸内視鏡検査を行いジャンボバイオプシー目的の内視鏡的粘膜切除術(Endoscopic mucosal resection:EMR)にて海綿状血管腫と診断した。後日多発する血管腫に対してpolidocanol(Aethoxysklerol)による硬化療法を行った。4日後の内視鏡観察では、血管腫は縮小を認め、以後黒色便も消失した。小腸に多発する血管腫に対して内視鏡的硬化療法が有用であった1例を経験したので報告する。(著者抄録)

  35. 今月の主題 知っておきたい小腸疾患 主題 小腸の非腫瘍性疾患-小腸リンパ管拡張症

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 丹羽 慶樹, 石川 恵里, 大塚 裕之, 鈴木 悠土, 西川 貴広, 石田 哲也, 久野 剛史, 服部 峻, 山田 啓策, 廣岡 芳樹, 藤城 光弘

    胃と腸   Vol. 54 ( 4 ) page: 532 - 536   2019.4

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1403201630

    CiNii Research

  36. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

    Fujiyoshi Toshihisa, Miyahara Ryoji, Funasaka Kohei, Furukawa Kazuhiro, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Nakaguro Masato, Nakatochi Masahiro, Hirooka Yoshiki

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 25 ( 10 ) page: 1248-1258   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3748/wjg.v25.i10.1248

    Web of Science

    Scopus

    PubMed

  37. A case of multiple hemangiomas of the small intestine treated by sclerotherapy using double-balloon enteroscopy

    Yamada K.

    Gastroenterological Endoscopy   Vol. 61 ( 6 ) page: 1231 - 1236   2019

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    Publisher:Gastroenterological Endoscopy  

    DOI: 10.11280/gee.61.1231

    Scopus

  38. Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease

    Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki

    GASTROENTEROLOGY RESEARCH AND PRACTICE   Vol. 2019   page: 4274257   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2019/4274257

    Web of Science

    Scopus

    PubMed

  39. 腸リンパ管拡張症の診断と治療

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 藤城 光弘

    日本小腸学会学術集会プログラム・抄録集   Vol. 3 ( 0 ) page: 34_2 - 34_2   2019

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    Language:Japanese   Publisher:日本小腸学会  

    <p>【背景・目的】 小腸内視鏡診断の進歩により腸リンパ管拡張症(Intestinal lymphangiectasia:IL)を含む蛋白漏出性腸症の小腸精査が可能になった。本研究の目的はILの臨床経過を後ろ向きに評価し、その特徴を明らかにしたうえでより良い治療法を模索することであった。</p><p>【対象と方法】 対象は2003年6月から2019年6月までにILと診断された17例(男性9例、女性8例、発症年齢は中央値37歳、0-75歳)であった。ILの診断は蛋白漏出性腸症と診断され且つ内視鏡下生検もしくは剖検にて病理学的に腸リンパ管拡張を認めたもので、他疾患が否定的であったものとした。白色絨毛、散布性白点を有する白色絨毛群(WV)と、異常なしもしくは軽度絨毛腫大、ケルクリング襞腫大を認める非白色絨毛群(NWV)に分けて臨床成績を比較検討した。</p><p>【結果】 WV、NWVは10例、7例であった。平均血清アルブミン値(g/dl)はWV:NWV = 2.0:1.2でNWVにおいて有意に低かった(P = 0.0061)。平均<i>α</i>1アンチトリプシンクリアランスはWV:NWV = 132:284(P = 0.0509)であった。ステロイド治療への反応はWV:NWV = 2/7:6/6 例でみられた。平均観察期間48箇月において1例のILが影響した死亡例を経験したが、重篤な真菌感染症によるものであった。</p><p>【結論】 NWV群は蛋白漏出は多いがステロイドへの反応がWV群よりも良好であった。治療のゴールドスタンダードは存在せず可能な可能で効果があるものを続けることが現状であった。</p>

    DOI: 10.32264/shocho.3.0_34_2

    CiNii Research

  40. Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease. Reviewed

    Journal of clinical medicine   Vol. 7 ( 10 )   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/jcm7100311

    PubMed

  41. クローン病小腸術後患者に対するエレンタールの使用効果と内視鏡診断

    中村 正直, 山村 健史, 前田 啓子, 澤田 つな騎, 水谷 泰之, 石川 卓哉, 古川 和宏, 舩坂 好平, 大野 栄三郎, 川嶋 啓揮, 宮原 良二, 廣岡 芳樹

    Biomedical Research on Trace Elements   Vol. 29 ( 1 ) page: 50 - 51   2018.6

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    Language:Japanese   Publisher:日本微量元素学会  

  42. Identification of Meflin as a Potential marker for mesenchymal stromal cells Reviewed

    Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M

    Scientific Reports     2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep22288

  43. Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis Reviewed

    Miyake N, Ando T, Ishiguro K, Maeda O, Watanabe O, Hirayama Y, Maeda K, Morise K, Matsushita M, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Ohmiya N, Goto H.

    World J Gastroenterol     2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3748/wjg.v21.i1.254

  44. Usefulness of Helicobacter pylori eradication for precancerous lesions of the gastric remnant Reviewed

    Sakakibara M, Ando T, Ishiguro K, Maeda O, Watanabe O, Hirayama Y, Morise K, Maeda K, Matsushita M, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Goto H

    J Gastroenterol Hepatol     2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.12772

  45. Dipeptidyl peptidase-4 inhibitor anagliptin facilitates restoration of dextran sulfate sodium-induced colitis. Reviewed

    Mimura S, Ando T, Ishiguro K, Maeda O, Watanabe O, Ujihara M, Hirayama Y, Morise K, Maeda K, Matsushita M, Funasaka K, Nakamura M, Miyahara R, Ozaki N, Goto H.

    Scand J Gastroenterol     2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/00365521.2013.832366

  46. Significance of cancer-associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer. Reviewed

    An J, Enomoto A, Weng L, Kato T, Iwakoshi A, Ushida K, Maeda K, Ishida-Takagishi M, Ishii G, Ming S, Sun T, Takahashi M

    J Cancer Res Clin Oncol     2013.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-012-1328-6

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MISC 12

  1. 腸管上皮細胞は、病原体の接着を認識し、エンドソームの機能調節を介して、侵入を阻害する

    前田啓子, Wayne I Lencer

    実験医学     2022.8

  2. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis Reviewed

    Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ohashi A, Kajikawa G, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Internal medicine (Tokyo, Japan)     2020.7

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    Language:English  

    DOI: 10.2169/internalmedicine.5302-20

    PubMed

  3. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma. Reviewed

    Hosono I, Miyahara R, Furukawa K, Funasaka K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Yokoi T, Tsukamoto T, Hirooka Y, Fujishiro M

    BMC gastroenterology   Vol. 20 ( 1 ) page: 175   2020.6

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    Language:English  

    DOI: 10.1186/s12876-020-01319-7

    PubMed

  4. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice Reviewed

    Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M

    Digestive diseases and sciences     2020.6

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    Language:English  

    DOI: 10.1007/s10620-020-06359-3

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  5. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn’s Disease Patients Reviewed

    Murate K, Maeda K, Nakamura M, Sugiyama D, Wada H, Yamamura T, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Miyahara R, Ishigami M, Nishikawa H, Fujishiro M

    Inflammatory bowel diseases     2020.5

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    DOI: 10.1093/ibd/izaa086

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  6. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study Reviewed

    Nishio R, Kawashima H, Nakamura M, Ohno E, Ishikawa T, Yamamura T, Maeda K, Sawada T, Tanaka H, Sakai D, Miyahara R, Ishigami M, Hirooka Y, Fujishiro M

    World journal of gastroenterology   Vol. 26 ( 10 ) page: 1056-1066   2020.3

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    DOI: 10.3748/wjg.v26.i10.1056

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  7. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis Reviewed

    Ishikawa T, Kawashima H, Ohno E, Tanaka H, Maeda K, Sawada T, Yamamura T, Furukawa K, Nakamura M, Miyahara R, Ishigami M, Fujishiro M

    Pancreas   Vol. 49 ( 2 ) page: e21-e22   2020.2

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    Language:English  

    DOI: 10.1097/MPA.0000000000001481

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  8. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma Reviewed

    Kobayashi K, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Okumura Y, Hirooka Y, Fujishiro M

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 32 ( 1 ) page: 65-73   2020.1

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    Language:English  

    DOI: 10.1111/den.13469

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  9. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope Reviewed

    Suzuki H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 15 ) page: 1795-1801   2020

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    Language:English  

    DOI: 10.2169/internalmedicine.4267-19

    PubMed

  10. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction Reviewed

    Hara A, Kobayashi H, Asai N, Saito S, Higuchi T, Kato K, Okumura T, Bando YK, Takefuji M, Mizutani Y, Miyai Y, Saito S, Maruyama S, Maeda K, Ouchi N, Nagasaka A, Miyata T, Mii S, Kioka N, Worthley DL, Murohara T, Takahashi M, Enomoto A

    Circulation research   Vol. 125 ( 4 ) page: 414-430   2019.8

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    DOI: 10.1161/CIRCRESAHA.119.314806

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  11. Hepatic portal venous gas following colonoscopy in a patient with Crohn's disease. Reviewed

    Ujihara M, Ando T, Ishiguro K, Maeda O, Watanabe O, Hirayama Y, Maeda K, Morise K, Matsushita M, Funasaka K, Nakamura M, Miyahara R, Ohmiya N, Goto H

    Nagoya journal of medical science   Vol. 75 ( 3-4 ) page: 273-8   2013.8

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  12. Importance of appropriate pharmaceutical management in pregnant women with ulcerative colitis. Reviewed

    Ujihara M, Ando T, Ishiguro K, Maeda O, Watanabe O, Hirayama Y, Morise K, Maeda K, Matsushita M, Miyahara R, Ohmiya N, Nishio Y, Yamaguchi T, Haruta J, Ina K, Goto H

    BMC research notes   Vol. 6   page: 210   2013.5

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    Language:English  

    DOI: 10.1186/1756-0500-6-210

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Presentations 5

  1. PARD6Bによる腸管上皮細胞の新たな防御機構の同定

    前田啓子, 中村正直, 藤城光弘

    消化器病学会総会 

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    Event date: 2019.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:石川県   Country:Japan  

  2. Innate Host Defense at Mucosal Surfaces by Rapid Degradation of Pard6B and Apkc to Deplete the Apical Endosome International conference

    Keiko Maeda, Nicholas Zachos, and Wayne I Lencer

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  3. Only the PARD6B Paralogue of the PARD6 Polarity Protein Family Regulates the Apical Endosomal Compartment of Canine MDCK Epithelial Cells International conference

    Keiko Maeda, Wayne I Lencer

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    Event date: 2017.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  4. クローン病におけるustekinumabの治療効果および予後予測因子の検討

    村手健太郎、前田啓子、藤代光弘

    日本消化器病学会総会  2021.4 

  5. 潰瘍性大腸炎の内視鏡的活動性と粘膜治癒を反映するバイオマーカーの同定

    前田啓子, 中村正直, 藤代光弘

    日本消化器病学会総会  2022.4.22 

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. PARD6Bを介した腸管上皮細胞の抗原認識機構の解明

    2022.11

    公益財団法人 武田科学振興財団 

Industrial property rights 2

  1. 炎症性腸疾患を治療するための医薬組成物

    前田啓子、浦野健

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    Application no:特願 PCT/JP2022/27035  Date applied:2022.7

  2. 間葉系幹細胞とペリサイトの新規マーカーの同定

    榎本篤、前田啓子、高橋雅英

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    Application no:2015153712  Date applied:2015

    Country of applicant:Domestic