論文 - 田中 都
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C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury 査読有り
Tanaka Miyako, Saka-Tanaka Marie, Ochi Kozue, Fujieda Kumiko, Sugiura Yuki, Miyamoto Tomofumi, Kohda Hiro, Ito Ayaka, Miyazawa Taiki, Matsumoto Akira, Aoe Seiichiro, Miyamoto Yoshihiro, Tsuboi Naotake, Maruyama Shoichi, Suematsu Makoto, Yamasaki Sho, Ogawa Yoshihiro, Suganami Takayoshi
JOURNAL OF EXPERIMENTAL MEDICINE 217 巻 ( 11 ) 頁： e20192230 2020年11月
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Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice 査読有り
A. Matsumoto*, M. Tanaka*, H. Matsumoto, K. Ochi, Y. Moro-oka, H. Kuwata, H. Yamada, I. Shirakawa, T. Miyazawa, H. Ishii, K. Kataoka, Y. Ogawa, Y. Miyahara, T. Suganami
Science advances 3 巻 ( 11 ) 頁： eaaq0723 2017年11月
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Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. 査読有り
M. Tanaka, K. Ikeda, T. Suganami, C. Komiya, K. Ochi, I. Shirakawa, M. Hamaguchi, S. Nishimura, I. Manabe, T. Matsuda, K. Kimura, H. Inoue, Y. Inagaki, S. Aoe, S. Yamasaki, Y. Ogawa
Nat Commun 5 巻 頁： 4982 2014年9月
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Novel cell-to-cell communications between macrophages and fibroblasts regulate obesity-induced adipose tissue fibrosis.
Kohda H, Tanaka M, Shichino S, Arakawa S, Komori T, Ito A, Wada E, Ochi K, Yuan X, Takeda T, Saiki A, Tatsuno I, Ikeda K, Miyai Y, Enomoto A, Morikawa Y, Shimizu S, Ueha S, Matsushima K, Ogawa Y, Suganami T
Diabetes 2025年3月
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Ishihara T, Kato K, Matsumoto K, Tanaka M, Hara A, Shiraki Y, Morisaki H, Urano Y, Ando R, Ito K, Mii S, Esaki N, Furuhashi K, Takefuji M, Suganami T, Murohara T, Enomoto A.
Genes to Cells 頁： 1 - 19 2024年8月
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Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia. 査読有り
Oya M, Miyasaka Y, Nakamura Y, Tanaka M, Suganami T, Mashimo T, Nakamura K
Cell metabolism 36 巻 頁： 1 - 15 2024年2月
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Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH 査読有り
Itoh Michiko, Tamura Atsushi, Kanai Sayaka, Tanaka Miyako, Kanamori Yohei, Shirakawa Ibuki, Ito Ayaka, Oka Yasuyoshi, Hidaka Isao, Takami Taro, Honda Yasushi, Maeda Mitsuyo, Saito Yasuyuki, Murata Yoji, Matozaki Takashi, Nakajima Atsushi, Kataoka Yosky, Ogi Tomoo, Ogawa Yoshihiro, Suganami Takayoshi
JOURNAL OF EXPERIMENTAL MEDICINE 220 巻 ( 11 ) 頁： e20220681 2023年9月
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Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages 査読有り
CELL DEATH & DISEASE 14 巻 ( 2 ) 頁： 136 2023年3月
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Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84 査読有り
Ohue-Kitano Ryuji, Nonaka Hazuki, Nishida Akari, Masujima Yuki, Takahashi Daisuke, Ikeda Takako, Uwamizu Akiharu, Tanaka Miyako, Kohjima Motoyuki, Igarashi Miki, Katoh Hironori, Tanaka Tomohiro, Inoue Asuka, Suganami Takayoshi, Hase Koji, Ogawa Yoshihiro, Aoki Junken, Kimura Ikuo
JCI INSIGHT 8 巻 ( 2 ) 頁： e165469 2023年1月
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Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis 査読有り
Inoue Takayuki, Fu Bin, Nishio Miwako, Tanaka Miyako, Kato Hisashi, Tanaka Masashi, Itoh Michiko, Yamakage Hajime, Ochi Kozue, Ito Ayaka, Shiraki Yukihiro, Saito Satoshi, Ihara Masafumi, Nishimura Hideo, Kawamoto Atsuhiko, Inoue Shian, Saeki Kumiko, Enomoto Atsushi, Suganami Takayoshi, Satoh-Asahara Noriko
NUTRIENTS 15 巻 ( 2 ) 頁： 350 2023年1月
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Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome 査読有り
Hachiya Rumi, Tanaka Miyako, Itoh Michiko, Suganami Takayoshi
INFLAMMATION AND REGENERATION 42 巻 ( 1 ) 頁： 13 2022年5月
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A Porous Reservoir-Backed Boronate Gel Microneedle for Efficient Skin Penetration and Sustained Glucose-Responsive Insulin Delivery. 査読有り
Chen S, Miyazaki T, Itoh M, Matsumoto H, Moro-Oka Y, Tanaka M, Miyahara Y, Suganami T, Matsumoto A
Gels (Basel, Switzerland) 8 巻 ( 2 ) 頁： 74 2022年1月
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The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model 査読有り
Yoshioka Naoki, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Ono Kenji, Sawada Makoto, Ogi Tomoo, Itoh Michiko, Ito Ayaka, Shiraki Yukihiro, Enomoto Atsushi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ogawa Yoshihiro, Suganami Takayoshi
BIOMEDICINE & PHARMACOTHERAPY 140 巻 頁： 111738 2021年8月
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Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity 査読有り
Kobayashi Azusa, Ito Ayaka, Shirakawa Ibuki, Tamura Atsushi, Tomono Susumu, Shindou Hideo, Hedde Per Niklas, Tanaka Miyako, Tsuboi Naotake, Ishimoto Takuji, Akashi-Takamura Sachiko, Maruyama Shoichi, Suganami Takayoshi
FRONTIERS IN IMMUNOLOGY 12 巻 頁： 650856 2021年6月
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Macrophages rely on extracellular serine to suppress aberrant cytokine production 査読有り
Kurita Kento, Ohta Hiroya, Shirakawa Ibuki, Tanaka Miyako, Kitaura Yasuyuki, Iwasaki Yorihiro, Matsuzaka Takashi, Shimano Hitoshi, Aoe Seiichiro, Arima Hiroshi, Ogawa Yoshihiro, Ito Ayaka, Suganami Takayoshi
SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 11137 2021年5月
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Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH 査読有り
Kanamori Yohei, Tanaka Miyako, Itoh Michiko, Ochi Kozue, Ito Ayaka, Hidaka Isao, Sakaida Isao, Ogawa Yoshihiro, Suganami Takayoshi
ISCIENCE 24 巻 ( 2 ) 頁： 102032 2021年2月
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Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome 査読有り
Oka Yasuyoshi, Hamada Motoharu, Nakazawa Yuka, Muramatsu Hideki, Okuno Yusuke, Higasa Koichiro, Shimada Mayuko, Takeshima Honoka, Hanada Katsuhiro, Hirano Taichi, Kawakita Toshiro, Sakaguchi Hirotoshi, Ichimura Takuya, Ozono Shuichi, Yuge Kotaro, Watanabe Yoriko, Kotani Yuko, Yamane Mutsumi, Kasugai Yumiko, Tanaka Miyako, Suganami Takayoshi, Nakada Shinichiro, Mitsutake Norisato, Hara Yuichiro, Kato Kohji, Mizuno Seiji, Miyake Noriko, Kawai Yosuke, Tokunaga Katsushi, Nagasaki Masao, Kito Seiji, Isoyama Keiichi, Onodera Masafumi, Kaneko Hideo, Matsumoto Naomichi, Matsuda Fumihiko, Matsuo Keitaro, Takahashi Yoshiyuki, Mashimo Tomoji, Kojima Seiji, Ogi Tomoo
SCIENCE ADVANCES 6 巻 ( 51 ) 頁： eabd7197 2020年12月
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Temperature-Stable Boronate Gel-Based Microneedle Technology for Self-Regulated Insulin Delivery 査読有り
Chen Siyuan, Miyazaki Takuya, Itoh Michiko, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira
ACS APPLIED POLYMER MATERIALS 2 巻 ( 7 ) 頁： 2781 - 2790 2020年7月
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Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system. 査読有り
Matsumoto A, Kuwata H, Kimura S, Matsumoto H, Ochi K, Moro-Oka Y, Watanabe A, Yamada H, Ishii H, Miyazawa T, Chen S, Baba T, Yoshida H, Nakamura T, Inoue H, Ogawa Y, Tanaka M, Miyahara Y, Suganami T
Communications biology 3 巻 ( 1 ) 頁： 313 2020年6月
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Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair. 査読有り
Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
Cell 180 巻 ( 6 ) 頁： 1228-1244.e24 2020年3月
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Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation 招待有り 査読有り
Tanaka Miyako
ENDOCRINE JOURNAL 67 巻 ( 2 ) 頁： 107-111 2020年2月
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Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. 査読有り
Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T
Scientific reports 10 巻 ( 1 ) 頁： 983 2020年1月
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Smart Microneedle Fabricated with Silk Fibroin Combined Semi interpenetrating Network Hydrogel for Glucose-Responsive Insulin Delivery 査読有り
Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira
ACS BIOMATERIALS SCIENCE & ENGINEERING 5 巻 ( 11 ) 頁： 5781-5789 2019年11月
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Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demand Insulin Delivery 査読有り
Chen Siyuan, Matsumoto Hiroko, Moro-oka Yuki, Tanaka Miyako, Miyahara Yuji, Suganami Takayoshi, Matsumoto Akira
ADVANCED FUNCTIONAL MATERIALS 29 巻 ( 7 ) 2019年2月
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Molecular mechanism of obesity-induced "metabolic" tissue remodeling. 査読有り
M. Tanaka, M. Itoh, Y. Ogawa, T. Suganami
J Diabetes Investig 2017年10月
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WNK4 is an adipogenic factor and its deletion reduces diet- induced obesity in mice. 査読有り
D. Takahashi, T. Mori, E. Sohara, M. Tanaka, M. Chiga, Y. Inoue, N. Nomura, M. Zeniya, H. Ochi, S. Takeda, T. Suganami, T. Rai, S. Uchida
EBioMedicine 18 巻 頁： 118-127 2017年4月
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Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. 査読有り
C. Komiya*, M. Tanaka*, K. Tsuchiya, N. Shimazu, K. Mori, S. Furuke, Y. Miyachi, K. Shiba, S. Yamaguchi, K. Ikeda, K. Ochi, K. Nakabayashi, K. Hata, M. Itoh, T. Suganami, Y. Ogawa
Scientific reports 7 巻 頁： 44754 2017年3月
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Inflammatory responses increase secretion of MD-1 protein. 査読有り
R. Thomas Jennings, E. Odkhuu, A. Nakashima, N. Morita, T. Kobayashi, I. Yamai, M. Tanaka, T. Suganami, S. Haga, M. Ozaki, Y. Watanabe, Y. Nagai, K. Takatsu, T. Kikuchi-Ueda, I. Ichimonji, Y. Ogawa, H. Takagi, T. Yamazaki, K. Miyake, S. Akashi-Takamura
International immunology 10 巻 頁： 503-512 2016年10月
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The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. 査読有り
R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa
Scientific reports 6 巻 頁： 28845 2016年6月
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Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice. 査読有り
Y. Watanabe, Y. Nagai, H. Honda, N. Okamoto, S. Yamamoto, T. Hamashima, Y. Ishii, M. Tanaka, T. Suganami, M. Sasahara, K. Miyake, K. Takatsu
Scientific reports 6 巻 頁： 23097 2016年3月
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Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. 査読有り
Y. Iwasaki, T. Suganami, R. Hachiya, I. Shirakawa, M. Kim-Saijo, M. Tanaka, M. Hamaguchi, T. Takai-Igarashi, M. Nakai, Y. Miyamoto, Y. Ogawa
Diabetes 63 巻 ( 1 ) 頁： 152-161 2014年1月
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Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. 査読有り
T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, S. Miura, O. Ezaki, T. Suganami, M. Okano, Y. Ogawa
Diabetes 61 巻 ( 10 ) 頁： 2442-2450 2012年10月
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Adipose tissue inflammation and ectopic lipid accumulation. 招待有り 査読有り
T. Suganami, M. Tanaka, Y. Ogawa
Endocrine journal 59 巻 ( 10 ) 頁： 849-857 2012年
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Melanocortin 4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis. 査読有り
M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa
Am J Pathol 179 巻 頁： 2455-2464 2011年
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Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. 査読有り
M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa
Diabetes 60 巻 頁： 819-826 2011年
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Role of central leptin signaling in the starvation-induced alteration of B-cell development. 査読有り
M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, Y. Ogawa
J Neurosci 31 巻 頁： 8373-8380 2011年
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Role of central leptin signaling in renal macrophage infiltration. 査読有り
M. Tanaka, T. Suganami, S. Sugita, Y. Shimoda, M. Kasahara, S. Aoe, M. Takeya, S. Takeda, Y. Kamei, Y. Ogawa
Endocr J 57 巻 頁： 61-72 2010年
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Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. 査読有り
A. Ito, T. Suganami, A. Yamauchi, M. Degawa-Yamauchi, M. Tanaka, R. Kouyama, Y. Kobayashi, N. Nitta, K. Yasuda, Y. Hirata, W.A. Kuziel, M. Takeya, S. Kanegasaki, Y. Kamei, Y. Ogawa
J Biol Chem 283 巻 頁： 35715-35723 2008年
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Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. 査読有り
M. Itoh, T. Suganami, N. Satoh, K.Tanimoto-Koyama, X. Yuan, M. Tanaka, H. Kawano, T. Yano, S. Aoe, M. Takeya, A. Shimatsu, H. Kuzuya, Y. Kamei, Y. Ogawa
Arterioscler Thromb Vasc Biol 27 巻 頁： 1918-1925 2007年
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Human MDR1 and MRP1 recognize berberine as their transport substrate. 査読有り
N. Shitan, M. Tanaka, K. Terai, K. Ueda, K. Yazaki
Biosci Biotechnol Biochem 71 巻 頁： 242-245 2007年
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Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. 査読有り
R. Kouyama, T. Suganami, J. Nishida, M. Tanaka, T. Toyoda, M. Kiso, T. Chiwata, Y. Miyamoto, Y. Yoshimasa, A. Fukamizu, M. Horiuchi, Y. Hirata, Y. Ogawa
Endocrinology 146 巻 頁： 3481-3489 2005年
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Application of Phospholipids Extracted from Bovine Milk to the Reconstitution of Cream Using Butter Oil. 査読有り
S. Miura, M. Tanaka, A. Suzuki, K. Sato
J Am Oil Chem Soc 81 巻 頁： 97-100 2004年
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Milk sphingomyelin accelerates enzymatic and morphological maturation of intestine in artificially reared rats. 査読有り
M. Motouri, H. Matsuyama, J. Yamamura, M. Tanaka, S. Aoe, T. Iwanaga, H. Kawakami
J Pediatr Gastroenterol Nutr 36 巻 頁： 241-247 2003年
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Milk basic protein: A novel protective function of milk against osteoporosis. 査読有り
Y. Toba, Y. Takada, J. Yamamura, M. Tanaka, Y. Matsuoka, H. Kawakami, A. Itabashi, S. Aoe, M. Kumegawa
Bone 27 巻 頁： 403-408 2000年
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Bioavailability of milk micellar calcium phosphate-phosphopeptide complex in rats. 査読有り
Y. Toba, K. Kato, Y. Takada, M. Tanaka, T. Nakano, T. Aoki, S. Aoe
J Nutr Sci Vitaminol 45 巻 頁： 311-323 1999年
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Comparison of the effects of milk components and calcium source on calcium bioability in glowing male rats. 査読有り
Y. Toba, Y. Takada, M. Tanaka, S. Aoe
Nutr Res 19 巻 頁： 449-459 1999年