研究者詳細 - 村上　裕

論文 - 村上　裕

分割表示 90 件中 41 - 60 件目／全件表示 >>

Ribosomal synthesis of peptides with C-terminal lactams, thiolactones, and alkylamides.

Nakajima E, Goto Y, Sako Y, Murakami H, Suga H

Chembiochem : a European journal of chemical biology 10 巻 ( 7 ) 頁： 1186 - 1192 2009年5月

Bases in the anticodon loop of tRNA(Ala)(GGC) prevent misreading.

Murakami H, Ohta A, Suga H

Nature structural & molecular biology 16 巻 ( 4 ) 頁： 353 - 358 2009年4月

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides.

Goto Y, Iwasaki K, Torikai K, Murakami H, Suga H

Chemical communications (Cambridge, England) ( 23 ) 頁： 3419 - 3419 2009年

Ribosomal synthesis of polypeptoids and peptoid-peptide hybrids.

Kawakami T, Murakami H, Suga H

Journal of the American Chemical Society 130 巻 ( 50 ) 頁： 16861 - 16863 2008年12月

Polymerization of alpha-hydroxy acids by ribosomes.

Ohta A, Murakami H, Suga H

Chembiochem : a European journal of chemical biology 9 巻 ( 17 ) 頁： 2773 - 2778 2008年11月

Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme.

Xiao H, Murakami H, Suga H, Ferré-D'Amaré AR

Nature 454 巻 ( 7202 ) 頁： 358 - 361 2008年7月

Initiating translation with D-amino acids.

Goto Y, Murakami H, Suga H

RNA (New York, N.Y.) 14 巻 ( 7 ) 頁： 1390 - 1398 2008年7月

Ribosomal synthesis of bicyclic peptides via two orthogonal inter-side-chain reactions.

Sako Y, Morimoto J, Murakami H, Suga H

Journal of the American Chemical Society 130 巻 ( 23 ) 頁： 7232 - 7234 2008年6月

Ribosomal synthesis of peptidase-resistant peptides closed by a nonreducible inter-side-chain bond.

Sako Y, Goto Y, Murakami H, Suga H

ACS chemical biology 3 巻 ( 4 ) 頁： 241 - 249 2008年4月

Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides. 査読有り

Goto Y, Ohta A, Sako Y, Yamagishi Y, Murakami H, Suga H

ACS chemical biology 3 巻 ( 2 ) 頁： 120 - 129 2008年2月

Messenger RNA-programmed incorporation of multiple N-methyl-amino acids into linear and cyclic peptides. 査読有り

Kawakami T, Murakami H, Suga H

Chemistry & biology 15 巻 ( 1 ) 頁： 32 - 42 2008年1月

Synthesis of polyester by means of genetic code reprogramming.

Ohta A, Murakami H, Higashimura E, Suga H

Chemistry & biology 14 巻 ( 12 ) 頁： 1315 - 1322 2007年12月

The flexizyme system: a highly flexible tRNA aminoacylation tool for the translation apparatus.

Ohuchi M, Murakami H, Suga H

Current opinion in chemical biology 11 巻 ( 5 ) 頁： 537 - 542 2007年10月

[Reprogramming the genetic code using flexizyme].

Sako Y, Murakami H, Suga H

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 52 巻 ( 13 Suppl ) 頁： 1643 - 8 2007年10月

Ribosomal Polyester Synthesis Using Reprogrammed Genetic Code 査読有り

Atsushi Ohta, Hiroshi Murakami, Hiroaki Suga

Kobunshi 56 巻 ( 4 ) 頁： 196 - 199 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）

The translation apparatus is sophisticated machinery that polymerizes amino acids to polypeptide according to the genetic triplets encoded on messenger RNA (mRNA) sequence. Because of this property, ribosome generally acts as a superb template-directed polymer synthesizer and therefore translated polypeptide shows narrow distribution of molecular weights with complete controlled sequence. Unfortunately, this superior system is limited to polypeptide synthesis because of the lack of genetic code which converts genetic triplets to any monomers except for 20 natural amino acids. To expand the application of ribosome, we utilized the concept of genetic code reprogramming to assign several codons as hydroxy acids and performed mRNA-templated polyester synthesis. We have demonstrated the sequence and length of polyesters can be controlled by the mRNA sequence as designed. This is a novel technology for the synthesis of polyester and polyester-polypeptide copolymer for the investigation of new materials. © 2007, The Society of Polymer Science, Japan. All rights reserved.

DOI： 10.1295/kobunshi.56.196

Scopus

In situ generation of aminoacyl-tRNAs assisted by ribozymes in translation apparatus. 査読有り

Ohuchi M, Murakami H, Suga H

Nucleic acids symposium series (2004) ( 51 ) 頁： 115 - 116 2007年

Exploration of incorporation of Nalpha-methylated amino acids into peptides by sense-suppression method. 査読有り

Kawakami T, Murakami H, Suga H

Nucleic acids symposium series (2004) ( 51 ) 頁： 361 - 362 2007年

[Expansion and reprogramming of genetic code by Flexizyme].

Murakami H, Suga H

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51 巻 ( 16 Suppl ) 頁： 2496 - 501 2006年12月

フレキシザイムを用いた遺伝暗号の拡張とリプログラミング (RNAと生命) -- (RNAテクノロジーと創薬)

村上裕, 菅裕明

蛋白質核酸酵素 51 巻 ( 16 ) 頁： 2496-2501 2006年12月

Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids.

Taki M, Kuno A, Matoba S, Kobayashi Y, Futami J, Murakami H, Suga H, Taira K, Hasegawa T, Sisido M

Chembiochem : a European journal of chemical biology 7 巻 ( 11 ) 頁： 1676 - 1679 2006年11月

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