2023/03/29 更新

写真a

ナリタ アツシ
成田 敦
NARITA Atsushi
所属
医学部附属病院 小児科 助教
大学院担当
大学院医学系研究科
職名
助教

学位 1

  1. 博士(医学) ( 2016年1月   名古屋大学 ) 

研究キーワード 2

  1. 造血細胞移植

  2. •小児血液腫瘍

研究分野 1

  1. ライフサイエンス / 胎児医学、小児成育学

経歴 2

  1. 名古屋大学   小児科   助教

    2017年12月 - 現在

  2. 名古屋大学   小児がん治療センター   病院助教

    2015年4月 - 2017年11月

学歴 2

  1. 名古屋大学   医学系研究科

    2011年4月 - 2015年3月

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    国名: 日本国

  2. 筑波大学   医学専門学群

    1998年4月 - 2005年3月

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    国名: 日本国

所属学協会 4

  1. 日本小児科学会

  2. 日本血液学会

  3. 日本小児血液・がん学会

  4. 日本造血細胞移植学会

委員歴 3

  1. 日本小児血液・がん学会   造血細胞移植委員会  

    2020年11月 - 現在   

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    団体区分:学協会

  2. 日本小児血液・がん学会   学術・調査委員会  

    2020年6月 - 現在   

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    団体区分:学協会

  3. 日本小児がん研究グループ   横紋筋肉腫委員会  

    2019年4月 - 現在   

 

論文 95

  1. Clinical diagnostic value of telomere length measurement in inherited bone marrow failure syndromes

    Miwata Shunsuke, Narita Atsushi, Okuno Yusuke, Suzuki Kyogo, Hamada Motoharu, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Narita Kotaro, Kitazawa Hironobu, Ichikawa Daisuke, Taniguchi Rieko, Kawashima Nozomu, Nishikawa Eri, Nishio Nobuhiro, Kojima Seiji, Muramatsu Hideki, Takahashi Yoshiyuki

    HAEMATOLOGICA   106 巻 ( 9 ) 頁: 2511 - 2515   2021年9月

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  2. Prospective randomized trial comparing two doses of rabbit anti-thymocyte globulin in patients with severe aplastic anaemia 査読有り

    Narita Atsushi, Zhu Xiaofan, Muramatsu Hideki, Chen Xiaojuan, Guo Ye, Yang Wenyu, Zhang Jingliao, Liu Fang, Jang Jun H., Kook Hoon, Kim Hawk, Usuki Kensuke, Yamazaki Hirohito, Takahashi Yoshiyuki, Nakao Shinji, Lee Jong Wook, Kojima Seiji

    BRITISH JOURNAL OF HAEMATOLOGY   187 巻 ( 2 ) 頁: 227 - 237   2019年10月

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    担当区分:筆頭著者  

    DOI: 10.1111/bjh.16055

    Web of Science

    PubMed

  3. Droplet digital PCR development for adenovirus load monitoring in children after hematopoietic stem cell transplantation.

    Haruta K, Takeuchi S, Yamaguchi M, Horiba K, Suzuki T, Torii Y, Narita A, Muramatsu H, Takahashi Y, Ito Y, Kawada JI

    The Journal of molecular diagnostics : JMD     2023年3月

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    記述言語:英語  

    DOI: 10.1016/j.jmoldx.2023.03.004

    PubMed

  4. Human leukocyte antigen 7/8-matched unrelated bone marrow transplantation using anti-thymocyte globulin in children

    Hamada Motoharu, Muramatsu Hideki, Torii Yuka, Suzuki Kyogo, Narita Atsushi, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Kawashima Nozomu, Taniguchi Rieko, Nishikawa Eri, Nishio Nobuhiro, Ito Yoshinori, Kojima Seiji, Takahashi Yoshiyuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY     2023年3月

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  5. Efficacy and safety of equine anti-thymocyte immunoglobulin (eATG) in three Japanese patients with moderate to very severe aplastic anemia: a case series (vol 117, pg 37, 2022)

    Kanda Yoshinobu, Mori Takehiko, Narita Atsushi, Wolter Kevin D., Yoshimatsu Hiroki, Nishimura Kazuma

    INTERNATIONAL JOURNAL OF HEMATOLOGY   117 巻 ( 3 ) 頁: 469 - 469   2023年3月

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  6. Germline and somatic RUNX1 variants in a pediatric bone marrow failure cohort

    Yamamori Ayako, Hamada Motoharu, Muramatsu Hideki, Wakamatsu Manabu, Hama Asahito, Narita Atsushi, Tsumura Yusuke, Yoshida Taro, Doi Takehiko, Terada Kazuki, Higa Takeshi, Yamamoto Nobuyuki, Miura Hiroki, Shiota Mitsutaka, Watanabe Kenichiro, Yoshida Nao, Maemura Ryo, Imaya Masayuki, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishio Nobuhiro, Iwafuchi Hideto, Ito Masafumi, Kojima Seiji, Okuno Yusuke, Takahashi Yoshiyuki

    AMERICAN JOURNAL OF HEMATOLOGY     2023年2月

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    記述言語:英語  

    DOI: 10.1002/ajh.26874

    Web of Science

    PubMed

  7. Efficacy and safety of equine anti-thymocyte immunoglobulin (eATG) in three Japanese patients with moderate to very severe aplastic anemia: a case series

    Kanda Yoshinobu, Mori Takehiko, Narita Atsushi, Wolter Kevin D., Yoshimatsu Hiroki, Nishimura Kazuma

    INTERNATIONAL JOURNAL OF HEMATOLOGY   117 巻 ( 1 ) 頁: 37 - 43   2023年1月

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  8. TREATMENT-RELATED TOXICITY OF ANTI-GD2 ANTIBODY IMMUNOTHERAPY AFTER ALLOGENEIC STEM CELL TRANSPLANTATION IN HIGH-RISK NEUROBLASTOMA PATIENTS

    Kataoka Shinsuke, Yamamori Ayako, Imaya Masayuki, Wakamatsu Manabu, Narita Kotaro, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  9. CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY FOLLOWED BY UR-BMT IN TYROSINE KINASE INHIBITOR RESISTANT PEDIATRIC PH1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

    Imaya Masayuki, Narita Atsushi, Nishio Nobuhiro, Wakamatsu Manabu, Taniguchi Rieko, Kataoka Shinsuke, Muramatsu Hideki, Ichikawa Daisuke, Maeda Naoko, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  10. DANAZOL ADDED TO IMMUNOSUPPRESSIVE THERAPY IN CHILDREN WITH APLASTIC ANEMIA: A PROPENSITY SCORE-MATCHED COHORT STUDY

    Narita Atsushi, Kudo Kazuko, Muramatsu Hideki, Yagasaki Hiroshi, Kobayashi Ryoji, Yabe Hiromasa, Ohara Akira, Ohga Shouichi, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  11. HEMATOLOGICAL ABNORMALITIES IN JACOBSEN SYNDROME: PATIENTS NOT ONLY DEVELOP THROMBOCYTOPENIA, BUT ALSO ANEMIA AND NEUTROPENIA

    Yamashita Daiki, Muramatsu Hideki, Narita Atsushi, Fujita Naoto, Koh Katsuyoshi, Umeda Katsutsugu, Morihana Eiji, Hama Asahito, Ito Masafumi, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  12. LI-FRAUMENI SYNDROME DIAGNOSED BY ONCOGENE PANEL TESTING FOR RHABDOMYOSARCOMA

    Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Yamashita Daiki, Sajiki Daichi, Imaya Masayuki, Wakamatsu Manabu, Narita Kotaro, Nishio Nobuhiro, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  13. RETROSPECTIVE NATIONWIDE SURVEY OF NONTUBERCULOUS MYCOBACTERIAL INFECTIONS IN PEDIATRIC HEMATOLOGY/ONCOLOGY PATIENTS

    Tsumura Yusuke, Muramatsu Hideki, Nishikawa Eri, Tetsuka Nobuyuki, Narita Atsushi, Inoue Kento, Cho Yuko, Motomura Yoshitomo, Hoshino Yoshihiko, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  14. RISK FACTORS FOR BLOOD STREAM INFECTIONS AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION IN CHILDREN

    Sajiki Daichi, Muramatsu Hideki, Wakamatsu Manabu, Narita Kotaro, Kataoka Shinsuke, Taniguchi Rieko, Narita Atsushi, Nishio Nobuhiro, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  15. THE DISAPPEARANCE OF MINIMAL RESIDUAL DISEASE IN BONE MARROW DEMONSTRATES GRAFT VERSUS NEUROBLASTOMA EFFECT AFTER KIR-LIGAND MISMATCHED ALLOGENEIC CBT

    Alahmadi Rowaida, Nishio Nobuhiro, Wakamatsu Manabu, Kataoka Shinsuke, Narita Kotaro, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   69 巻   2022年11月

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  16. Risk factors for unplanned removal of central venous catheters in hospitalized children with hematological and oncological disorders

    Miyagishima Moe, Hamada Motoharu, Hirayama Yuji, Muramatsu Hideki, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Imaizumi Takahiro, Nakatochi Masahiro, Kamei Michi, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   116 巻 ( 2 ) 頁: 288 - 294   2022年8月

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  17. METABOLOMICS OF URINARY METABOLITES IN CHILDHOOD RHABDOMYOSARCOMA TO DISCOVER NOVEL BIOMARKERS

    Nakano Satoshi, Uchida Hiroo, Amano Hizuru, Narita Atsushi, Abe Mayumi, Ishigaki Takashi, Sakairi Minoru, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Takada Shunya, Nakagawa Yoichi, Terui Yasushi, Sunagawa Masaki, Takahashi Yoshiyuki, Osawa Tsuyoshi, Hinoki Akinari

    PEDIATRIC BLOOD & CANCER   69 巻   2022年6月

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  18. Combination chemotherapy consisting of irinotecan, etoposide, and carboplatin for refractory or relapsed neuroblastoma

    Imaya Masayuki, Muramatsu Hideki, Narita Atsushi, Yamamori Ayako, Wakamatsu Manabu, Yoshida Taro, Miwata Shunsuke, Narita Kotaro, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    CANCER MEDICINE   11 巻 ( 9 ) 頁: 1956 - 1964   2022年5月

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    記述言語:英語  

    DOI: 10.1002/cam4.4529

    Web of Science

    PubMed

  19. Minor PNH clones do not distinguish inherited bone marrow failure syndromes from immune-mediated aplastic anemia

    Narita Atsushi, Miwata Shunsuke, Imaya Masayuki, Tsumura Yusuke, Yamamori Ayako, Wakamatsu Manabu, Hamada Motoharu, Taniguchi Rieko, Okuno Yusuke, Muramatsu Hideki, Takahashi Yoshiyuki

    BLOOD ADVANCES   6 巻 ( 8 ) 頁: 2517 - 2519   2022年4月

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  20. Prospective validation of the provisional entity of refractory cytopenia of childhood, proposed by the World Health Organization

    Hama Asahito, Hasegawa Daisuke, Manabe Atsushi, Nozawa Kazue, Narita Atsushi, Muramatsu Hideki, Kosaka Yoshiyuki, Kobayashi Masao, Koh Katsuyoshi, Takahashi Yoshiyuki, Watanabe Kenichiro, Ohara Akira, Ito Masafumi, Kojima Seiji

    BRITISH JOURNAL OF HAEMATOLOGY   196 巻 ( 4 ) 頁: 1031 - 1039   2022年2月

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    記述言語:英語  

    DOI: 10.1111/bjh.17921

    Web of Science

    PubMed

  21. Clinical Impact of Melphalan Pharmacokinetics on Transplantation Outcomes in Children Undergoing Hematopoietic Stem Cell Transplantation

    Maemura Ryo, Wakamatsu Manabu, Matsumoto Kana, Sakaguchi Hirotoshi, Yoshida Nao, Hama Asahito, Yoshida Taro, Miwata Shunsuke, Kitazawa Hironobu, Narita Kotaro, Kataoka Shinsuke, Ichikawa Daisuke, Hamada Motoharu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Nishio Nobuhiro, Kato Koji, Kojima Seiji, Morita Kunihiko, Muramatsu Hideki, Takahashi Yoshiyuki

    CELL TRANSPLANTATION   31 巻   頁: 9636897221143364   2022年

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  22. Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia

    Kitazawa Hironobu, Okuno Yusuke, Muramatsu Hideki, Aoki Kosuke, Murakami Norihiro, Wakamatsu Manabu, Suzuki Kyogo, Narita Kotaro, Kataoka Shinsuke, Ichikawa Daisuke, Hamada Motoharu, Taniguchi Rieko, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Hama Asahito, Loh Mignon L., Stieglitz Elliot, Kojima Seiji, Takahashi Yoshiyuki

    BLOOD ADVANCES   5 巻 ( 24 ) 頁: 5507 - 5518   2021年12月

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  23. A Phase I Study of CD19 Chimeric Antigen Receptor-T Cells Generated By the PiggyBac Transposon Vector for Acute Lymphoblastic Leukemia

    Nishio Nobuhiro, Hanajiri Ryo, Ishikawa Yuichi, Murata Makoto, Taniguchi Rieko, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

    BLOOD   138 巻   頁: 3831 - +   2021年11月

  24. Using Chemotherapy to Treat Neuroblastoma Stage 4S with Hepatomegaly in a Patient Younger than 2 Months Old

    Imaya Masayuki, Nishio Nobuhiro, Taniguchi Rieko, Kataoka Shinsuke, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  25. Outcomes of KIR-Ligand Incompatible Allogeneic Cord Blood Transplantation for Relapsed Stage 4 Neuroblastoma: A Single Institutional Study

    Kataoka Shinsuke, Nishio Nobuhiro, Wakamatsu Manabu, Taniguchi Rieko, Nishikawa Eri, Hamada Motoharu, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  26. Prolonged Hospitalization and Late Gastroenterological Complications in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

    Kawashima Nozomu, Kataoka Shinsuke, Hamada Motoharu, Nishikawa Eri, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  27. RE-Treatment with CD19-Targeted CAR-T Cells for Relapse after CD19-CAR-T Cell Therapy

    Nishio Nobuhiro, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Wang Kai, Zheng Huyong, Chang Jung-Li, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  28. Strategy of Intensified Therapy for High Risk Pediatric Acute Lymphoblastic Leukemia Based on NGS-MRD-Based Risk Stratification

    Hamada Motoharu, Imaya Masayuki, Okuno Yusuke, Kawashima Nozomu, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Hasegawa Shinji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  29. Successful Therapy with Ascites Drainage and Defibrotide for Veno-Occlusive Disease Developed after Bone Marrow Transplantation in Acute Lymphoblastic Leukemia

    Maemura Ryo, Narita Atsushi, Kataoka Shinsuke, Taniguchi Rieko, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Nishio Nobuhiro, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  30. Ten Patients with RUNX1 Mutation who were Suspected with FPD-MM in a Pediatric Cohort of Inherited Bone Marrow Failure Syndrome

    Yamamori Ayako, Hamada Motoharu, Muramatsu Hideki, Taniguchi Rieko, Kataoka Shinsuke, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Okuno Yusuke, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  31. Urinary Biomarkers Predicting Treatment Outcomes in Neuroblastoma

    Narita Atsushi, Hinoki Akinari, Yokota Kazuki, Hamada Motoharu, Kataoka Shinsuke, Kawashima Nozomu, Muramatsu Hideki, Nishio Nobuhiro, Uchida Hiroo, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   68 巻   2021年11月

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  32. Autoantibodies against the plakin family proteins as a novel marker for chronic graft-versus-host disease of the lung

    Kawashima Nozomu, Nishikawa Eri, Tsuchisaka Atsunari, Hashimoto Takashi, Okuno Yusuke, Hamada Motoharu, Ichikawa Daisuke, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Muro Yoshinao, Takahashi Yoshiyuki

    BONE MARROW TRANSPLANTATION   56 巻 ( 9 ) 頁: 2291 - 2294   2021年9月

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  33. Echocardiography Monitoring of Pulmonary Hypertension after Pediatric Hematopoietic Stem Cell Transplantation: Pediatric Pulmonary Arterial Hypertension and Pulmonary Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation

    Kawashima Nozomu, Fukasawa Yoshie, Nishikawa Eri, Ohta-Ogo Keiko, Ishibashi-Ueda Hatsue, Hamada Motoharu, Ichikawa Daisuke, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Kato Taichi, Takahashi Yoshiyuki

    TRANSPLANTATION AND CELLULAR THERAPY   27 巻 ( 9 ) 頁: 786.e1 - 786.e8   2021年9月

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  34. Successful treatment of a novel type I interferonopathy due to a de novo PSMB9 gene mutation with a Janus kinase inhibitor 査読有り

    Kataoka Shinsuke, Kawashima Nozomu, Okuno Yusuke, Muramatsu Hideki, Miwata Shunsuke, Narita Kotaro, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Ichikawa Daisuke, Kitazawa Hironobu, Suzuki Kyogo, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Yamamoto Hidenori, Fukasawa Yoshie, Kato Taichi, Yamamoto Hiroyuki, Natsume Jun, Kojima Seiji, Nishino Ichizo, Taketani Takeshi, Ohnishi Hidenori, Takahashi Yoshiyuki

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   148 巻 ( 2 ) 頁: 639 - 644   2021年8月

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  35. Relationship between plasma rabbit anti-thymocyte globulin concentration and immunosuppressive therapy response in patients with severe aplastic anemia

    Narita Atsushi, Muramatsu Hideki, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Suzuki Kyogo, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Hama Asahito, Yamazaki Hirohito, Nakao Shinji, Kojima Seiji, Takahashi Yoshiyuki

    EUROPEAN JOURNAL OF HAEMATOLOGY   107 巻 ( 2 ) 頁: 255 - 264   2021年8月

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    記述言語:英語  

    DOI: 10.1111/ejh.13644

    Web of Science

    PubMed

  36. Integrated diagnosis based on transcriptome analysis in suspected pediatric sarcomas

    Ichikawa Daisuke, Yamashita Kyoko, Okuno Yusuke, Muramatsu Hideki, Murakami Norihiro, Suzuki Kyogo, Kojima Daiei, Kataoka Shinsuke, Hamada Motoharu, Taniguchi Rieko, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Hama Asahito, Kasai Kenji, Mizuno Seiji, Shimoyama Yoshie, Nakaguro Masato, Okita Hajime, Kojima Seiji, Nakazawa Atsuko, Takahashi Yoshiyuki

    NPJ GENOMIC MEDICINE   6 巻 ( 1 ) 頁: 49   2021年6月

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  37. Urinary biomarkers for monitoring treatment response in neuroblastoma patients.

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Takahashi Yoshiyuki, Narita Atsushi, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi

    JOURNAL OF CLINICAL ONCOLOGY   39 巻 ( 15 )   2021年5月

  38. Detection of subclonal SETBP1 and JAK3 mutations in juvenile myelomonocytic leukemia using droplet digital PCR 査読有り

    Wakamatsu Manabu, Okuno Yusuke, Murakami Norihiro, Miwata Shunsuke, Kitazawa Hironobu, Narita Kotaro, Kataoka Shinsuke, Ichikawa Daisuke, Hamada Motoharu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Muramatsu Hideki, Takahashi Yoshiyuki

    LEUKEMIA   35 巻 ( 1 ) 頁: 259 - 263   2021年1月

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  39. A Breast-Fed Baby with Low KREC in TREC/KREC Newborn Screening Whose Mother Received Azathioprine Treatment

    Wakamatsu Manabu, Muramatsu Hideki, Kojima Daiei, Okuno Yusuke, Sakai Yoshimi, Nakajima Yoko, Ito Tetsuya, Kawashima Nozomu, Narita Atsushi, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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    記述言語:日本語  

    Web of Science

  40. Clinical Features of Cord Colitis Syndrome in Children

    Maemura Ryo, Narita Atsushi, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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    記述言語:日本語  

    Web of Science

  41. Allogeneic Stem Cell Transplantation from Alternative Donors for Children with Aplastic Anemia

    Narita Atsushi, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Yoshida Taro, Wakamatsu Manabu, Miwata Shunsuke, Narita Koutaro, Kitazawa Hironobu, Taniguchi Rieko, Hamada Motoharu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    BONE MARROW TRANSPLANTATION   55 巻 ( SUPPL 1 ) 頁: 215 - 216   2020年12月

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    記述言語:日本語  

    Web of Science

  42. Allogeneic Hematopoietic Cell Transplantation in First Remission in Children with AML: A Comparison of RIC and MAC

    Hama Asahito, Yamashita Daiki, Sajiki Daichi, Kitazawa Hironobu, Sakaguchi Hirotoshi, Yoshida Nao, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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    記述言語:日本語  

    Web of Science

  43. Viral Reactivations in Children with Aplastic Anemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

    Narita Atsushi, Ito Yoshinori, Kawashima Nozomu, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Torii Yuka, Kawada Junichi, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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  44. Strategy of Stem Cell Transplantation at 1st Molecular CR for Pediatric Acute Lymphoblastic Leukemia with MEF2D-BCL9 Fusion

    Hamada Motoharu, Imaya Masayuki, Okuno Yusuke, Ichikawa Daisuke, Kawashima Nozomu, Narita Atsushi, Nishikawa Eri, Muramatsu Hideki, Nishio Nobuhiro, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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  45. Effect of Azacitidine in a Child with Fanconi Anemia and Myelodysplastic Syndrome Harboring Monosomy 7

    Kawashima Nozomu, Ito Masafumi, Narita Kotaro, Ichikawa Daisuke, Nishikawa Eri, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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  46. Favorable Prognosis of Patients with Intermediate-Risk Neuroblastoma Having Residual Tumor after Treatment

    Nishio Nobuhiro, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   67 巻   2020年12月

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  47. Risk factors for secondary poor graft function after bone marrow transplantation in children with acquired aplastic anemia 査読有り

    Hama Asahito, Muramatsu Hideki, Narita Atsushi, Nishikawa Eri, Kawashima Nozomu, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC TRANSPLANTATION   24 巻 ( 7 ) 頁: e13828   2020年11月

  48. Conditioning regimen for allogeneic bone marrow transplantation in children with acquired bone marrow failure: fludarabine/melphalan vs. fludarabine/cyclophosphamide

    Yoshida Nao, Takahashi Yoshiyuki, Yabe Hiromasa, Kobayashi Ryoji, Watanabe Kenichiro, Kudo Kazuko, Yabe Miharu, Miyamura Takako, Koh Katsuyoshi, Kawaguchi Hiroshi, Goto Hiroaki, Fujita Naoto, Okada Keiko, Okamoto Yasuhiro, Kato Koji, Inoue Masami, Suzuki Ritsuro, Atsuta Yoshiko, Kojima Seiji, Kato Keisuke, Muramatsu Hideki, Narita Atsushi, Wakamatsu Manabu

    BONE MARROW TRANSPLANTATION   55 巻 ( 7 ) 頁: 1272 - 1281   2020年7月

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    記述言語:日本語  

    DOI: 10.1038/s41409-020-0948-8

    Web of Science

  49. A Case of a 14-Year-Old Boy who had Difficulty Walking Due to Drug-Induced Neuropathy During T-Cell Acute Lymphocytic Leukemia Treatment

    Yoshida Taro, Sawamura Aya, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Nishikawa Eri, Hamada Motoharu, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Nakata Tomohiko, Kidokoro Hiroyuki, Natxume Jun, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S30 - S30   2019年12月

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    記述言語:日本語  

    Web of Science

  50. Correlation Between Plasma Rabbit Anti-Thymocyte Globulin Level and Response to Immunosuppressive Therapy in Patients With Severe Aplastic Anemia

    Narita Atsushi, Muramatsu Hideki, Hamada Motoharu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Yamazaki Hirohito, Nakao Shinji, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S45 - S45   2019年12月

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    記述言語:日本語  

    Web of Science

  51. An Infant With Hereditary Folate Malabsorption Requiring Differentiation from Acute Megakaryoblastic Leukemia

    Nishikawa Eri, Taniguchi Rieko, Yoshida Tarou, Imaya Masayuki, Wakamatsu Manabu, Miwata Syunsuke, Narita Koutarou, Yamamori Ayako, Kitazawa Hironobu, Ichikawa Daisuke, Hamada Motoharu, Kawashima Nozomu, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Said Shimaa, Tozawa Yusuke, Yamada Masafumi, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S73 - S73   2019年12月

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    記述言語:日本語  

    Web of Science

  52. A CaseWith Dyskeratosis Congenita Achieved Transfusion Independence after Eltrombopag Treatment

    Wakamatsu Manabu, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Yoshida Taro, Miwata Shunsuke, Kitazawa Hironobu, Narita Kotaro, Ichikawa Disuke, Hamada Motoharu, Taniguchi Rieko, Kawasima Nozomu, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S46 - S46   2019年12月

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    記述言語:日本語  

    Web of Science

  53. Whole Exome Sequencing Contributes to Genetic Diagnosis of IBMFS Patients

    Muramatsu Hideki, Hamada Motoharu, Okuno Yusuke, Wakamatsu Manabu, Taniguchi Rieko, Narita Koutarou, Kawashima Nozomu, Kitazawa Hironobu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nazomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Ogi Tomoo, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S63 - S64   2019年12月

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  54. Usefulness of Telomere Length Measurement for Inherited Bone Marrow Failure Syndromes

    Miwata Shunsuke, Narita Atsushi, Hamada Motoharu, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Narita Kotaro, Kitazawa Hironobu, Ichikawa Daisuke, Taniguchi Rieko, Kawasima Nozomu, Nisikawa Eri, Hideki Muramatu, Nisio Nobuhiro, Okuno Yusuke, Kojima Seiji, Sakaguchi Hirotoshi, Hama Asahito, Takahasi Yosiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S45 - S46   2019年12月

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  55. Evaluation of the Outcome of KIR-Ligand Mismatched Cord Blood Transplantation for High Risk Metastatic Neuroblastoma Using New SIOPEN Risk Stratification

    Nishio Nobuhiro, Ichikawa Daisuke, Wakamatsu Manabu, Narita Kotaro, Miwata Shunsuke, Kitazawa Hironobu, Taniguchi Rieko, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S106 - S106   2019年12月

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  56. Genetic Diagnosis Based on a Comprehensive Fusion Gene Analysis of Pediatric Malignant Solid Tumors

    Ichikawa Daisuke, Muramatsu Hideki, Okuno Yusuke, Hamada Motoharu, Taniguchi Rieko, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Shimoyama Yoshie, Nakaguro Masato, Nakamura Shigeo, Kojima Seiji, Nakazawa Atsuko, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S61 - S61   2019年12月

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  57. Induction of Partial Response With Ceritinib for a Child With Chemotherapy-Refractory ALK-rearranged Neuroblastoma

    Narita Kotaro, Yoshida Taro, Yamamori Ayako, Wakamatsu Manabu, Imaya Masayuki, Miwata Shunsuke, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Nishio Nobuhiro, Okuno Yusuke, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S104 - S104   2019年12月

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  58. Integrating FANCD2 Functional Analysis With High-Throughput Sequencing for Diagnosing Fanconi Anemia

    Kawashima Nozomu, Okuno Yusuke, Muramatsu Hideki, Taniguchi Rieko, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Hamada Motoharu, Ichikawa Daisuke, Kitazawa Nobuhiro, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S44 - S45   2019年12月

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  59. Successful Treatment of Central Nervous System Relapses of Neuroblastoma Stage 4 After a KIR-ligand Mismatched Allogeneic Cord Blood Transplantation

    Imaya Masayuki, Narita Atsushi, Yoshida Taro, Yamamori Ayako, Wakamatsu Manabu, Miwata Syunsuke, Narita Kotaro, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Hamada Motoharu, Nishikawa Eri, Kawashima Nozomu, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S102 - S102   2019年12月

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  60. Successfully Treated Three Children With Pericardial Effusion After Hematopoietic Stem Cell Transplantation

    Kitazawa Hironobu, Narita Atsushi, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Taniguchi Rieko, Hamada Motoharu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S97 - S97   2019年12月

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  61. Two Cases Effectively Treated with Oral Budesonide Administration for Steroid-resistant Intestinal Acute Graft Versus Host Disease

    Yamamori Ayako, Nishikawa Eri, Narita Atsushi, Imaya Masayuki, Wakamatsu Manabu, Yoshida Taro, Miwata Shunsuke, Kitazawa Hironobu, Narita Kotaro, Taniguchi Rieko, Ichikawa Daisuke, Hamada Motoharu, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   66 巻   頁: S37 - S38   2019年12月

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  62. Genome-Wide Methylation Analysis Using the Digital Restriction Enzyme Analysis of Methylation for Stratification of Patients with Juvenile Myelomonocytic Leukemia

    Kitazawa Hironobu, Muramatsu Hideki, Murakami Norihiro, Okuno Yusuke, Wakamatsu Manabu, Yoshida Taro, Imaya Masayuki, Yamamori Ayako, Miwata Shunsuke, Narita Kotaro, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    BLOOD   134 巻   2019年11月

  63. Allogeneic stem cell transplantation with reduced intensity conditioning for patients with adrenoleukodystrophy

    Kato Koji, Maemura Ryo, Wakamatsu Manabu, Yamamori Ayako, Hamada Motoharu, Kataoka Shinsuke, Narita Atsushi, Miwata Shunsuke, Sekiya Yuko, Kawashima Nozomu, Suzuki Kyogo, Narita Kotaro, Doisaki Sayoko, Muramatsu Hideki, Sakaguchi Hirotoshi, Matsumoto Kimikazu, Koike Yuka, Onodera Osamu, Kaga Makiko, Shimozawa Nobuyuki, Yoshida Nao

    MOLECULAR GENETICS AND METABOLISM REPORTS   18 巻   頁: 1 - 6   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ymgmr.2018.11.001

    Web of Science

    PubMed

  64. Randomized Trial of Two Dosages of Rabbit Antithymocyte Globulin in Patients with Aplastic Anemia

    Narita Atsushi, Zhu Xiaofan, Muramatsu Hideki, Chen Xiaojuan, Guo Ye, Yang Wenyu, Zhang Jingliao, Liu Fang, Jang Jun Ho, Kook Hoon, Kim Hawk, Usuki Kensuke, Yamazaki Hirohito, Takahashi Yoshiyuki, Nakao Shinji, Lee Jong-Wook, Kojima Seiji

    BLOOD   132 巻   2018年11月

  65. Application of RNA Sequencing for Early Diagnosis of NUT Carcinoma: A Case Report

    Miwata Shunsuke, Narita Atsushi, Wakamatsu Manabu, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Ichikawa Daisuke, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Nishio Nobuhiro, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S74 - S74   2018年11月

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    記述言語:日本語  

    Web of Science

  66. Disappearance of Minimal Residual Disease Demonstrates Graft Versus Neuroblastoma Effect After KIR-Ligand Mismatched Allogeneic Cord Blood Transplantation

    Nishio Nobuhiro, Kataoka Shinsuke, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S8 - S8   2018年11月

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    記述言語:日本語  

    Web of Science

  67. Urgent Successful HLA-Haploidentical Stem Cell Transplantation in Children with Aplastic Anemia Considering Upfront SCT Strategy

    Nishikawa Eri, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Murakami Norihiro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Kitazawa Hironobu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S65 - S66   2018年11月

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  68. Morphological Features of Bone Marrow in Patients with Inherited Bone Marrow Failure

    Hama Asahito, Hasegawa Daisuke, Manabe Atsushi, Nozawa Kazue, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Takahashi Yoshiyuki, Watanabe Kenichiro, Ohara Akira, Ito Masafumi, Kojima Seiji

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S66 - S66   2018年11月

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  69. NGS-Based Methylation Analysis of Juvenile Myelomonocytic Leukemia using the Digital Restriction Enzyme Analysis of Methylation (DREAM) Method

    Kitazawa Hironobu, Murakami Norihiro, Okuno Yusuke, Muramatsu Hideki, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S22 - S23   2018年11月

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  70. Relapse After Spontaneous Molecular Remission in a Female with Congenital Acute Myeloid Leukemia with KAT6A-EP300 Fusion Transcript

    Taniguchi Rieko, Kawashima Nozomu, Ikawa Yasuhiro, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Kitazawa Hironobu, Suzuki Kyogo, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Nishimura Ryosei, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S98 - S98   2018年11月

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  71. Unmet Medical Needs for Japanese Kampo Medicine in Children with Hematological and Oncological Disease

    Kawashima Nozomu, Miwata Shunsuke, Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Suzuki Kyogo, Kitazawa Hironobu, Nishikawa Eri, Okuno Yusuke, Taniguchi Rieko, Narita Atsushi, Muramatsu Hideki, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   65 巻   頁: S33 - S33   2018年11月

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  72. Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia 査読有り

    Hamada Motoharu, Doisaki Sayoko, Okuno Yusuke, Muramatsu Hideki, Hama Asahito, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Yoshida Kenichi, Kanno Hitoshi, Manabe Atsushi, Taga Takashi, Takahashi Yoshiyuki, Miyano Satoru, Ogawa Seishi, Kojima Seiji

    INTERNATIONAL JOURNAL OF HEMATOLOGY   108 巻 ( 3 ) 頁: 306 - 311   2018年9月

  73. Updated Treatment Algorism for Children with Acquired Aplastic Anemia: A Report from the Japan Childhood Aplastic Anemia Study Group

    Yoshida Nao, Narita Atsushi, Muramatsu Hideki, Kobayashi Ryoji, Yabe Hiromasa, Kudo Kazuko, Yagasaki Hiroshi, Watanabe Kenichiro, Morimoto Akira, Ito Etsuro, Ohga Shouichi, Ohara Akira, Takahashi Yoshiyuki, Kojima Seiji

    BONE MARROW TRANSPLANTATION   53 巻   頁: 34 - 35   2018年9月

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  74. Risk Factors for Viral Infections in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

    Narita Atsushi, Ito Yoshinori, Torii Yuka, Kawada Jun-Ichi, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Kataoka Shinsuke, Ichikawa Daisuke, Ito Rieko, Murakami Norihiro, Kojima Daiei, Suzuki Kyogo, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Muramatsu Hideki, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

    BONE MARROW TRANSPLANTATION   53 巻   頁: 588 - 589   2018年9月

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  75. Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR

    Hamada Motoharu, Nishio Nobuhiro, Okuno Yusuke, Suzuki Satoshi, Kawashima Nozomu, Muramatsu Hideki, Tsubota Shoma, Wilson Matthew H., Morita Daisuke, Kataoka Shinsuke, Ichikawa Daisuke, Murakami Norihiro, Taniguchi Rieko, Suzuki Kyogo, Kojima Daiei, Sekiya Yuko, Nishikawa Eri, Narita Atsushi, Hama Asahito, Kojima Seiji, Nakazawa Yozo, Takahashi Yoshiyuki

    EBIOMEDICINE   34 巻   頁: 18-26   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ebiom.2018.07.008

    Web of Science

    PubMed

  76. Diagnostic performance of F-18-FDG PET/CT and whole-body diffusion-weighted imaging with background body suppression (DWIBS) in detection of lymph node and bone metastases from pediatric neuroblastoma 査読有り

    Ishiguchi Hiroaki, Ito Shinji, Kato Katsuhiko, Sakurai Yusuke, Kawai Hisashi, Fujita Naotoshi, Abe Shinji, Narita Atsushi, Nishio Nobuhiro, Muramatsu Hideki, Takahashi Yoshiyuki, Naganawa Shinji

    ANNALS OF NUCLEAR MEDICINE   32 巻 ( 5 ) 頁: 348 - 362   2018年6月

  77. Integrated molecular profiling of juvenile myelomonocytic leukemia 査読有り

    Murakami Norihiro, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Nagae Genta, Suzuki Kyogo, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Ito Masafumi, Hirayama Masashi, Watanabe Arata, Ueno Toshihide, Kojima Seiji, Aburatani Hiroyuki, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takahashi Yoshiyuki, Muramatsu Hideki

    BLOOD   131 巻 ( 14 ) 頁: 1576 - 1586   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1182/blood-2017-07-798157

    Web of Science

    PubMed

  78. Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes 査読有り

    Su Zhendong, Kishida Satoshi, Tsubota Shoma, Sakamoto Kazuma, Cao Dongliang, Kiyonari Shinichi, Ohira Miki, Kamijo Takehiko, Narita Atsushi, Xu Yinyan, Takahashi Yoshiyuki, Kadomatsu Kenji

    ONCOTARGET   8 巻 ( 63 ) 頁: 106296 - 106310   2017年12月

  79. Unrelated cord blood transplantation in aplastic anemia: is anti-thymocyte globulin indispensable for conditioning? 査読有り

    Kudo K., Muramatsu H., Narita A., Yoshida N., Kobayashi R., Yabe H., Endo M., Inoue M., Hara J., Kounami S., Inagaki J., Hashii Y., Kato K., Tabuchi K., Kojima S.

    BONE MARROW TRANSPLANTATION   52 巻 ( 12 ) 頁: 1659 - 1661   2017年12月

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  80. Bevacizumab, Irinotecan, and Temozolomide Combination as Salvage Chemotherapy for Relapsed Pediatric Brain Tumor

    Kataoka Shinsuke, Muramatsu Hideki, Narita Kotaro, Hamada Motoharu, Murakami Norihiro, Tanigushi Rieko, Ichikawa Daisuke, Kitazawa Hironori, Kojima Daiei, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S55 - S55   2017年11月

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    記述言語:日本語  

    Web of Science

  81. Vorinostat and Bortezomib Combined Intensive Chemotherapy for Children with KMT2A (MLL)-rearranged Acute Lymphoblastic Leukemia

    Suzuki Kyogo, Muramatsu Hideki, Okuno Yusuke, Narita Kotaro, Kitazawa Hironobu, Huang Yue, Ichikawa Daisuke, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Taniguchi Rieko, Kojima Daiei, Sekiya Yuko, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S90 - S90   2017年11月

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  82. Successful Allogeneic Cord Blood Transplantation in three Children with Aplastic Anemia Pretreated with Flu plus Mel plus TBI

    Nishikawa Eri, Kitazawa Hironobu, Narita Koutarou, Hamada Motoharu, Kataoka Shinsuke, Murakami Norihiro, Ichikawa Daisuke, Kojima Daiei, Suzuki Kyogo, Taniguchi Rieko, Kawashima Nozomu, Narita Atsushi, Okuno Yusuke, Muramatsu Hideki, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S75 - S76   2017年11月

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  83. Identification of FLVCR1 as a Novel Causative Gene of Inherited Ineffective Erythropoiesis in Humans

    Kawashima Nozomu, Okuno Yusuke, Shiota Mitsutaka, Muramatsu Hideki, Yoshida Kenichi, Ikawa Masahito, Hama Asahito, Ito Masafumi, Doisaki Sayoko, Murakami Norihiro, Suzuki Kyogo, Narita Atsushi, Nishio Nobuhiro, Takahashi Yoshiyuki, Ogawa Seishi, Kojima Seiji

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S20 - S20   2017年11月

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  84. Integrated Molecular Profiling of Juvenile Myelomonocytic Leukemia

    Murakami Norihiro, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Nagae Genta, Suzuki Kyogo, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Nishio Nobuhiro, Hama Asahito, Sanada Masashi, Hirayama Masashi, Watanabe Arata, Ueno Toshihide, Kojima Seiji, Aburatani Hiroyuki, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S19 - S20   2017年11月

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  85. Killer Cell Immunoglobulin-like Receptor Ligand-mismatched Allogeneic Cord Blood Transplantation Reduces Relapse and Improves Survival in Children with Refractory Neuroblastoma

    Nishio Nobuhiro, Kataoka Shinnsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Kojima Daiei, Suzuki Kyogo, Kawasima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S23 - S24   2017年11月

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  86. Newborn Screening for Severe Combined Immunodeficiency in Aichi Prefecture

    Kojima Daiei, Muramatsu Hideki, Okuno Yusuke, Narita Kotaro, Murakami Norihiro, Ichikawa Daisuke, Hamada Motoharu, Kataoka Shinsuke, Kitazawa Hironobu, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Narita Atsushi, Nishio Nobuhiro, Hama Asahito, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER   64 巻   頁: S33 - S33   2017年11月

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  87. Development of clinical paroxysmal nocturnal haemoglobinuria in children with aplastic anaemia 査読有り

    Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Sekiya Yuko, Suzuki Kyogo, Hamada Motoharu, Kataoka Shinsuke, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Kojima Daiei, Nishikawa Eri, Kawashima Nozomu, Nishio Nobuhiro, Hama Asahito, Takahashi Yoshiyuki, Kojima Seiji

    BRITISH JOURNAL OF HAEMATOLOGY   178 巻 ( 6 ) 頁: 954 - 958   2017年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/bjh.14790

    Web of Science

    PubMed

  88. Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm 査読有り

    Suzuki K., Suzuki Y., Hama A., Muramatsu H., Nakatochi M., Gunji M., Ichikawa D., Hamada M., Taniguchi R., Kataoka S., Murakami N., Kojima D., Sekiya Y., Nishikawa E., Kawashima N., Narita A., Nishio N., Nakazawa Y., Iwafuchi H., Watanabe K-i, Takahashi Y., Ito M., Kojima S., Kato S., Okuno Y.

    LEUKEMIA   31 巻 ( 7 ) 頁: 1629 - 1633   2017年7月

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  89. Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes 査読有り

    Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Doisaki Sayoko, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Takahashi Yoshiyuki, Kanno Hitoshi, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Ogawa Seishi, Miyano Satoru, Kojima Seiji

    GENETICS IN MEDICINE   19 巻 ( 7 ) 頁: 796 - 802   2017年7月

  90. Bone marrow transplantation for children with acquired bone marrow failure

    Hama A., Manabe A., Hasegawa D., Nozawa K., Suzuki K., Narita A., Muramatsu H., Takahashi Y., Watanabe K., Ohara A., Ito M., Kojima S.

    BONE MARROW TRANSPLANTATION   52 巻   頁: S414 - S414   2017年7月

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    記述言語:日本語  

    Web of Science

  91. Danaparoid reduces the transplant related mortality for stem cell transplantation in children

    Kato K., Sakaguchi H., Muramatsu H., Sekiya Y., Kawashima N., Narita A., Doisaki S., Watanabe N., Yoshida N., Matsumoto K.

    BONE MARROW TRANSPLANTATION   52 巻   頁: S281 - S282   2017年7月

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    記述言語:日本語  

    Web of Science

  92. RECURRENT MYB REARRANGEMENT IN BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM

    Suzuki K., Okuno Y., Suzuki Y., Hama A., Muramatsu H., Nakatochi M., Gunji M., Ichikawa D., Hamada M., Taniguchi R., Kataoka S., Murakami N., Kojima D., Sekiya Y., Nishikawa E., Kawashima N., Narita A., Nishio N., Nakazawa Y., Iwafuchi H., Watanabe K., Ito M., Kojima S., Kato S., Takahashi Y.

    HAEMATOLOGICA   102 巻   頁: 35 - 35   2017年6月

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  93. PiggyBac Mediated T Cells Expressing Anti CD19 Chimeric Antigen Receptor for a Clinical Trial

    Nishio Nobuhiro, Nakazawa Yozo, Hamada Motoharu, Suzuki Satoshi, Tanaka Miyuki, Morita Daisuke, Kawashima Nozomu, Okuno Yusuke, Narita Atsushi, Hama Asahito, Muramatsu Hideki, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    MOLECULAR THERAPY   25 巻 ( 5 ) 頁: 291 - 291   2017年5月

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  94. Clinical utility of next-generation sequencing-based minimal residual disease in paediatric B-cell acute lymphoblastic leukaemia 査読有り

    Sekiya Yuko, Xu Yinyan, Muramatsu Hideki, Okuno Yusuke, Narita Atsushi, Suzuki Kyogo, Wang Xinan, Kawashima Nozomu, Sakaguchi Hirotoshi, Yoshida Nao, Hama Asahito, Takahashi Yoshiyuki, Kato Koji, Kojima Seiji

    BRITISH JOURNAL OF HAEMATOLOGY   176 巻 ( 2 ) 頁: 248 - 257   2017年1月

  95. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia. 査読有り

    Narita A, Muramatsu H, Sekiya Y, Okuno Y, Sakaguchi H, Nishio N, Yoshida N, Wang X, Xu Y, Kawashima N, Doisaki S, Hama A, Takahashi Y, Kudo K, Moritake H, Kobayashi M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S; Japan Childhood Aplastic Anemia Study Group.

    Haematologica.   100 巻 ( 12 ) 頁: 1546-1552   2015年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3324/haematol.2015.132530

▼全件表示

講演・口頭発表等 10

  1. A Breast-Fed Baby with Low KREC in TREC/KREC Newborn Screening Whose Mother Received Azathioprine Treatment

    Wakamatsu Manabu, Muramatsu Hideki, Kojima Daiei, Okuno Yusuke, Sakai Yoshimi, Nakajima Yoko, Ito Tetsuya, Kawashima Nozomu, Narita Atsushi, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2020年12月 

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    会議種別:口頭発表(一般)  

  2. A Case of a 14-Year-Old Boy who had Difficulty Walking Due to Drug-Induced Neuropathy During T-Cell Acute Lymphocytic Leukemia Treatment

    Yoshida Taro, Sawamura Aya, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Taniguchi Rieko, Ichikawa Daisuke, Nishikawa Eri, Hamada Motoharu, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Nakata Tomohiko, Kidokoro Hiroyuki, Natxume Jun, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2019年12月 

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    会議種別:ポスター発表  

  3. High Natural Killer Cell Count at Diagnosis Predicts a Good Response to Immunosuppressive Therapy in Aplastic Anemia 国際会議

    Narita Atsushi, Muramatsu Hideki, Xu Yinyan, Hamada Motoharu, Ichikawa Daisuke, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Yamazaki Hirohito, Nakao Shinji, Kojima Seiji, Takahashi Yoshiyuki

    BLOOD  2019年11月13日 

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    会議種別:ポスター発表  

  4. Relationship between plasma rabbit anti-thymocyte globulin level and response to immunosuppressive therapy in patients with severe aplastic anemia: Results of a multicenter, prospective, randomized study 国際会議

    Narita Atsushi, Muramatsu Hideki, Xu Yinyan, Nishikawa Eri, Kawashima Nozomu, Okuno Yusuke, Nishio Nobuhiro, Hama Asahito, Yamazaki Hirohito, Nakao Shinji, Kojima Seiji, Takahashi Yoshiyuki

    BONE MARROW TRANSPLANTATION  2019年7月 

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    会議種別:口頭発表(一般)  

  5. Germline Mutation in Pediatric Patients with Aplastic Anemia

    Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Wang Xinan, Xu Yinyan, Kawashima Nozomu, Nishio Nobuhiro, Hama Asahito, Sakaguchi Hirotoshi, Yoshida Nao, Kato Koji, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2017年11月 

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    会議種別:口頭発表(一般)  

  6. Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches

    Narita Atsushi, Muramatsu Hideki, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Hitoshi Kanno, Yamaguchi Hiroki, Ohga Shouichi, Manabe Atsushi, Harigae Hideo, Kunishima Shinji, Ishii Eiichi, Kobayashi Masao, Koike Kenichi, Watanabe Kenichiro, Ito Etsuro, Takata Minoru, Yabe Miharu, Ogawa Seishi, Miyano Satoru, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2018年11月 

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    会議種別:口頭発表(一般)  

  7. A Case of Dyskeratosis Congenital who Showed the Improvement of Telomere Length After Receiving Androgens for 11 Years

    Wakamatsu Manabu, Nishio Nobuhiro, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Kataoka Shinsuke, Hamada Motoharu, Murakami Norihiro, Ichikawa Daisuke, Taniguchi Rieko, Suzuki Kyogo, Kawashima Nozomu, Nishikawa Eri, Okuno Yusuke, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2018年11月 

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    会議種別:ポスター発表  

  8. A CaseWith Dyskeratosis Congenita Achieved Transfusion Independence after Eltrombopag Treatment

    Wakamatsu Manabu, Muramatsu Hideki, Imaya Masayuki, Yamamori Ayako, Yoshida Taro, Miwata Shunsuke, Kitazawa Hironobu, Narita Kotaro, Ichikawa Disuke, Hamada Motoharu, Taniguchi Rieko, Kawasima Nozomu, Nishikawa Eri, Narita Atsushi, Okuno Yusuke, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2019年12月 

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    会議種別:口頭発表(一般)  

  9. A Case of Thoracic Tumor Caused by SMARCA4 Biallelic Inactivation

    Ichikawa Daisuke, Muramatsu Hideki, Okuno Yusuke, Wakamatsu Manabu, Miwata Shunsuke, Narita Kotaro, Kitazawa Hironobu, Hamada Motoharu, Kataoka Shinsuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2018年11月 

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    会議種別:口頭発表(一般)  

  10. A Case of MLL-AF9 Fusion Positive Malignant Lymphoma Without Bone Marrow Infiltration Either at First Diagnosis or at Relapse

    Narita Kotaro, Kataoka Shinsuke, Hamada Motoharu, Ichikawa Daisuke, Taniguchi Rieko, Murakami Norihiro, Suzuki Kyogo, Nishikawa Eri, Nishio Nobuhiro, Okuno Yusuke, Kawashima Nozomu, Narita Atsushi, Muramatsu Hideki, Kojima Seiji, Takahashi Yoshiyuki

    PEDIATRIC BLOOD & CANCER  2018年11月 

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    会議種別:ポスター発表  

▼全件表示

科研費 5

  1. シングルセル遺伝子発現解析を用いた小児骨髄不全症の病態解明

    研究課題/研究課題番号:22K07819  2022年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    成田 敦, 村松 秀城, 奥野 友介, 高橋 義行

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    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    後天性の小児骨髄不全の診断においては、再生不良性貧血とRefractory cytopenia of childhood (RCC) の鑑別が問題となる。RCCは骨髄異形成症候群の一病型とされ、再生不良性貧血とは形態学的に区別されるが、汎血球減少をきたし、免疫抑制療法が奏功する点については差異がなく,病態機構の異同については明らかになっていない。本研究の目的はRCCを含む小児骨髄不全の病態機構を解明することである。患者臨床検体を用いて、形態学的診断、次世代シーケンサーによる網羅的遺伝子解析、シングルセル遺伝子発現解析を実施し、造血の初期プロセスや疾患発症に関与する免疫学的機構を解明する。

  2. 横紋筋肉腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索

    研究課題/研究課題番号:22K07911  2022年4月 - 2025年3月

    科学研究費補助金   基盤研究(C)

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    担当区分:研究分担者 

  3. 腎芽腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索

    研究課題/研究課題番号:22K07276  2022年4月 - 2025年3月

    科学研究費補助金   基盤研究(C)

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    担当区分:研究分担者 

  4. マウスモデルを用いた再生不良性貧血の新規遺伝子機能解析

    研究課題/研究課題番号:19K08297  2019年4月 - 2022年3月

    科学研究費助成事業  基盤研究(C)

    成田 敦, 奥野 友介, 高橋 義行

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    担当区分:研究代表者 

    配分額:3900000円 ( 直接経費:3000000円 、 間接経費:900000円 )

    再生不良性貧血(Aplastic anemia; AA)は、造血幹細胞に対する自己免疫反応が原因で起こると考えられているが病態の解明は十分ではない。我々は、小児AA患者41症例の全エクソーム解析を通じて、血液疾患との関連性についてはこれまでに報告がない、新規遺伝子Xの体細胞変異を2例で同定した。さらに我々は、小児AA140症例についてPyro sequencing法を実施し、8症例(6%)で同様に遺伝子Xの変異を確認した。本研究の目的は、遺伝子Xの変異マウスモデルを用いて、AAにおける新規遺伝子Xの機能的意義を検討し、AAの病態機構を明らかにすることである。
    小児再生不良性貧血患者検体を用いて全エクソーム解析を実施し、新規遺伝子Xの変異を複数の症例に同定した。遺伝子Xの変異が再生不良性貧血患者において骨髄増殖または免疫回避における優位性を示すのではないかと仮説し、遺伝子Xの変異マウスモデルを用いて、再生不良性貧血における新規遺伝子Xの変異アリルの機能的意義を検討した。遺伝子Xの変異マウスから骨髄検体を採取し、コロニーアッセイ、RNAシーケンス解析による発現解析、MHC欠失の解析、骨髄競合移植実験を実施した。いずれの結果においても遺伝子Xの変異がコントロールに比べて骨髄増殖または免疫回避における優位性はみられなかった。
    本研究では再生不良性貧血における新規遺伝子X変異アリルの機能的意義を検討した。遺伝子Xは、がん悪性化にも関与する遺伝子の制御因子として知られているが、血液疾患との関連性についてはこれまでに報告がない。本研究は、再生不良性貧血の病態機構に関する研究を補完するだけでなく、遺伝子Xにおける機能について解析を実施することで、他疾患の病態解明にも影響を与えうるものである。

  5. 小児再生不良性貧血におけるクローン性造血の網羅的遺伝子解析

    研究課題/研究課題番号:17K16248  2017年4月 - 2019年3月

    科学研究費助成事業  若手研究(B)

    成田 敦, 高橋 義行, 村松 秀城, 奥野 友介, 中杤 昌弘

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    担当区分:研究代表者 

    配分額:2990000円 ( 直接経費:2300000円 、 間接経費:690000円 )

    小児再生不良性貧血(AA)の57症例を後方視的に解析した。観察期間中に5例がPNHを発症し、10年累積発症率は10.2% (95% CI, 3.6%-20.7%)であった。AA診断時とPNH発症時の検体をターゲットシーケンス解析した結果、AA診断時には遺伝子変異を認めなかったが、PNH発症後にPIGA遺伝子変異を全例で検出した。
    小児AA患者41症例について全エクソーム解析を実施した。複数例に同定された変異遺伝子の中に新規遺伝子X(2例)を認めた。追加検討で小児AA140症例のうち8症例(6%)に遺伝子X変異を同定した。遺伝子Xの変異部位は同一であることから、機能獲得型変異であると考えられた。
    小児再生不良性貧血(AA)に発作性夜間血色素尿症(PNH)が合併することが知られている。我々は小児AA患者57例をの長期予後を調査したところ、観察期間中に5例がPNHを発症しており、10年累積発症率は10.2% (95% CI, 3.6%-20.7%)であった。また、AAからPNHを発症した5例では、AA診断時のフローサイトメトリーで微小PNH血球が全例で陽性であった。AA診断時とPNH発症時の検体をターゲットシーケンス解析した結果、AA診断時にはPIGA遺伝子変異を認めなかったが、PNH発症後にPIGA遺伝子変異を全例で検出した。