Updated on 2024/09/18

写真a

 
TORII Youta
 
Organization
Nagoya University Hospital Psychiatry Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2013.3   名古屋大学 ) 

Education 1

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2013.3

      More details

    Country: Japan

Professional Memberships 4

  1. 日本神経精神医学会

  2. 日本老年精神医学会

  3. 日本認知症学会

  4. 日本生物学的精神医学会

 

Papers 50

  1. Association between copy number variations in parkin (<i>PRKN</i>) and schizophrenia and autism spectrum disorder: A case-control study

    Lo, TY; Kushima, I; Kimura, H; Aleksic, B; Okada, T; Kato, H; Inada, T; Nawa, Y; Torii, Y; Yamamoto, M; Kimura, R; Funabiki, Y; Kosaka, H; Numata, S; Kasai, K; Sasaki, T; Yokoyama, S; Munesue, T; Hashimoto, R; Yasuda, Y; Fujimoto, M; Usami, M; Itokawa, M; Arai, M; Ohi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Yamasue, H; Iwata, N; Ikeda, M; Ozaki, N

    NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 44 ( 1 ) page: 42 - 50   2024.3

     More details

  2. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction

    Ishikawa, M; Yamamoto, Y; Wulaer, B; Kunisawa, K; Fujigaki, H; Ando, T; Kimura, H; Kushima, I; Arioka, Y; Torii, Y; Mouri, A; Ozaki, N; Nabeshima, T; Saito, K

    FEBS JOURNAL   Vol. 291 ( 5 ) page: 945 - 964   2024.3

     More details

  3. Neuropathological substrate of incident dementia in older patients with schizophrenia: A clinicopathological study

    Arafuka, S; Fujishiro, H; Torii, Y; Sekiguchi, H; Habuchi, C; Miwa, A; Yoshida, M; Iritani, S; Iwasaki, Y; Ikeda, M; Ozaki, N

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 78 ( 1 ) page: 29 - 40   2024.1

     More details

  4. Structural aging of human neurons is opposite of the changes in schizophrenia

    Mizutani, R; Saiga, R; Yamamoto, Y; Uesugi, M; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M

    PLOS ONE   Vol. 18 ( 6 ) page: e0287646   2023.6

     More details

  5. Response to 'Fluctuation of dopamine transporter availability in psychiatric-onset dementia with Lewy bodies: the dilemma of treatment with antidepressants'

    Fujishiro, H; Matsubayashi, R; Torii, Y; Iwamoto, K

    PSYCHOGERIATRICS   Vol. 23 ( 3 ) page: 556 - 557   2023.5

     More details

  6. Late-onset panic disorder as the initial presentation in autopsy-confirmed dementia with Lewy bodies

    Arafuka, S; Sekiguchi, H; Fujishiro, H; Iritani, S; Torii, Y; Habuchi, C; Yoshida, M; Iwasaki, Y; Ozaki, N; Fujita, K

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 77 ( 4 ) page: 242 - 244   2023.4

     More details

  7. An autopsy case of schizophrenia comorbid with argyrophilic grain disease

    Torii, Y; Iritani, S; Fujishiro, H; Sekiguchi, H; Habuchi, C; Ikeda, T; Yoshida, M; Iwasaki, Y; Ozaki, N; Kawashima, K

    PSYCHOGERIATRICS   Vol. 23 ( 2 ) page: 371 - 373   2023.3

     More details

  8. Electroconvulsive therapy as a potential therapeutic option in psychiatric-onset prodromal dementia with Lewy bodies

    Kimura, H; Yokoyama, H; Torii, Y; Fujishiro, H

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   Vol. 38 ( 1 ) page: e5863   2023.1

     More details

  9. Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with Lewy bodies: a case report

    Fujishiro, H; Arafuka, S; Ogasawara, K; Iwamoto, K; Miyata, S; Torii, Y; Iritani, S; Ozaki, N

    PSYCHOGERIATRICS   Vol. 23 ( 1 ) page: 196 - 200   2023.1

     More details

  10. Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder

    Kushima, I; Nakatochi, M; Aleksic, B; Okada, T; Kimura, H; Kato, H; Morikawa, M; Inada, T; Ishizuka, K; Torii, Y; Nakamura, Y; Tanaka, S; Imaeda, M; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Ogawa, N; Iritani, S; Hayashi, Y; Lo, TY; Otgonbayar, G; Furuta, S; Iwata, N; Ikeda, M; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Ohi, K; Shioiri, T; Kitaichi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Sasaki, T; Tochigi, M; Nishimura, F; Yamasue, H; Kuwabara, H; Wakuda, T; Kato, TA; Kanba, S; Horikawa, H; Usami, M; Kodaira, M; Watanabe, K; Yoshikawa, T; Toyota, T; Yokoyama, S; Munesue, T; Kimura, R; Funabiki, Y; Kosaka, H; Jung, MY; Kasai, K; Ikegame, T; Jinde, S; Numata, S; Kinoshita, M; Kato, T; Kakiuchi, C; Yamakawa, K; Suzuki, T; Hashimoto, N; Ishikawa, S; Yamagata, B; Nio, S; Murai, T; Son, S; Kunii, Y; Yabe, H; Inagaki, M; Goto, Y; Okumura, Y; Ito, T; Arioka, Y; Mori, D; Ozaki, N

    BIOLOGICAL PSYCHIATRY   Vol. 92 ( 5 ) page: 362 - 374   2022.9

     More details

  11. Striatal <SUP>123</SUP>I-2β-carbomethoxy-3b-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single-photon emission computed tomography demonstrates nigral degeneration in the early stage of behavioural variant frontotemporal dementia: an autopsy case with frontotemporal lobar degeneration with trans-activation response DNA protein 43 type B

    Arafuka, S; Fujishiro, H; Iritani, S; Torii, Y; Miwa, A; Yabata, H; Sekiguchi, H; Habuchi, C; Kawashima, K; Yoshida, M; Iwasaki, Y; Ozaki, N

    PSYCHOGERIATRICS   Vol. 22 ( 4 ) page: 580 - 585   2022.7

     More details

  12. ゲノム解析研究とブレインバンク

    荒深周生, 鳥居洋太, 尾崎紀夫

    精神科   Vol. 40 ( 4 )   2022.4

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  13. 【認知症の疾患概念について考える;歴史的事項から将来まで】レビー小体病の臨床病理学的概念とレビー小体型認知症診断基準の変遷

    竹田和弘, 鳥居洋太, 入谷修司, 藤城弘樹

    老年精神医学雑誌   Vol. 32 ( 10 ) page: 1058 - 1067   2021.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  14. Visual text hallucinations in a patient with posterior cortical atrophy attributable to Alzheimer's disease and Lewy body disease Reviewed

    Takeda Kazuhiro, Torii Youta, Fujishiro Hiroshige, Atsuta Naoki, Iritani Shuji, Kawashima Kunihiro

    PSYCHOGERIATRICS   Vol. 21 ( 4 ) page: 683 - 685   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/psyg.12701

    Web of Science

    PubMed

  15. Schizophrenia-Like Behavioral Impairments in Mice with Suppressed Expression of Piccolo in the Medial Prefrontal Cortex Reviewed

    Nitta Atsumi, Izuo Naotaka, Hamatani Kohei, Inagaki Ryo, Kusui Yuka, Fu Kequan, Asano Takashi, Torii Youta, Habuchi Chikako, Sekiguchi Hirotaka, Iritani Shuji, Muramatsu Shin-ichi, Ozaki Norio, Miyamoto Yoshiaki

    JOURNAL OF PERSONALIZED MEDICINE   Vol. 11 ( 7 )   2021.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/jpm11070607

    Web of Science

    PubMed

  16. Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures Reviewed

    Saiga Rino, Uesugi Masayuki, Takeuchi Akihisa, Uesugi Kentaro, Suzuki Yoshio, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Torii Youta, Kushima Itaru, Iritani Shuji, Ozaki Norio, Oshima Kenichi, Itokawa Masanari, Arai Makoto, Mizutani Ryuta

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11768   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-91233-z

    Web of Science

    PubMed

  17. Clinicopathological investigation of the background of cognitive decline in elderly schizophrenia Reviewed

    Miwa Ayako, Hirano Mitsuaki, Torii Youta, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Yoshida Mari, Iwai Kiyoshi, Kawashima Kunihiro, Iritani Shuji

    ACTA NEUROPSYCHIATRICA   Vol. 33 ( 2 ) page: 85 - 91   2021.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/neu.2020.40

    Web of Science

    PubMed

  18. Can we identify prodromal dementia with Lewy bodies in late-life depression? Reviewed

    Sekiguchi Hirotaka, Fujishiro Hiroshige, Torii Youta, Iritani Shuji, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 75 ( 3 ) page: 113 - 114   2021.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.13187

    Web of Science

    PubMed

  19. Dopaminergic circuitry in late-life depression and Lewy body disease Reviewed

    Fujishiro Hiroshige, Torii Youta, Iritani Shuji, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 75 ( 2 ) page: 69 - 70   2021.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.13181

    Web of Science

    PubMed

  20. Structural diverseness of neurons between brain areas and between cases Reviewed

    Mizutani Ryuta, Saiga Rino, Yamamoto Yoshiro, Uesugi Masayuki, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Torii Youta, Kushima Itaru, Iritani Shuji, Ozaki Norio, Oshima Kenichi, Itokawa Masanari, Arai Makoto

    TRANSLATIONAL PSYCHIATRY   Vol. 11 ( 1 ) page: 49   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41398-020-01173-x

    Web of Science

    PubMed

  21. Gender differences in early presentation and pathological subtypes in dementia with Lewy bodies Reviewed

    Fujishiro Hiroshige, Torii Youta, Iritani Shuji

    PSYCHOGERIATRICS   Vol. 21 ( 1 ) page: 142 - 143   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/psyg.12626

    Web of Science

    PubMed

  22. Globular glial tauopathy Type I presenting with behavioral variant frontotemporal dementia Reviewed

    Hirano Mitsuaki, Iritani Shuji, Fujishiro Hiroshige, Torii Youta, Kawashima Kunihiro, Sekiguchi Hirotaka, Habuchi Chikako, Yamada Kentaro, Ikeda Toshimasa, Hasegawa Masato, Ikeuchi Takeshi, Yoshida Mari, Ozaki Norio

    NEUROPATHOLOGY   Vol. 40 ( 5 ) page: 515 - 525   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/neup.12668

    Web of Science

    PubMed

  23. Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study Reviewed

    Torii Youta, Iritani Shuji, Marui Tomoyasu, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Kushima Itaru, Oshima Kenichi, Niizato Kazuhiro, Hayashida Shotaro, Masaki Katsuhisa, Kira Jun-ichi, Yoshida Mari, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 223   page: 353 - 355   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.schres.2020.07.003

    Web of Science

    PubMed

  24. The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study.

    Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H, Kushima I, Kawakami I, Itokawa M, Arai M, Hayashida S, Masaki K, Kira JI, Kawashima K, Ozaki N

    Schizophrenia research   Vol. 223   page: 356 - 358   2020.9

     More details

    Language:English  

    DOI: 10.1016/j.schres.2020.09.012

    PubMed

  25. The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study Reviewed

    Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Kushima Itaru, Kawakami Ito, Itokawa Masanari, Arai Makoto, Hayashida Shotaro, Masaki Katsuhisa, Kira Jun-ichi, Kawashima Kunihiro, Ozaki Norio

    SCHIZOPHRENIA RESEARCH   Vol. 223   page: 356 - 358   2020.9

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  26. Background of the neuropathological site in neurocognitive decline in elderly schizophrenic patients

    Hirano, M; Iritani, S; Sekiguchi, H; Torii, Y; Habuchi, C; Fujishiro, H; Ozaki, N; Yoshida, M; Fujita, K

    PSYCHOGERIATRICS   Vol. 20 ( 4 ) page: 522 - 527   2020.7

     More details

  27. Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT)

    Itokawa, M; Oshima, K; Arai, M; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Saiga, R; Mizutani, R

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 3 ) page: 176 - 182   2020.3

     More details

  28. Clinicopathological differences between the motor onset and psychiatric onset of Huntington's disease, focusing on the nucleus accumbens

    Hirano, M; Iritani, S; Fujishiro, H; Torii, Y; Habuchi, C; Sekiguchi, H; Yoshida, M; Ozaki, N

    NEUROPATHOLOGY   Vol. 39 ( 5 ) page: 331 - 341   2019.10

     More details

  29. Hypochondriasis in the elderly and Lewy body disease

    Fujishiro, H; Kimura, H; Nakamura, T; Torii, Y; Iritani, S; Ozaki, N

    PSYCHOGERIATRICS   Vol. 19 ( 5 ) page: 516 - 518   2019.9

     More details

  30. Clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia

    Fujishiro, H; Okuda, M; Iwamoto, K; Miyata, S; Torii, Y; Iritani, S; Ozaki, N

    JOURNAL OF NEURAL TRANSMISSION   Vol. 126 ( 8 ) page: 1095 - 1104   2019.8

     More details

  31. Neuropathological investigation of the nucleus accumbens focusing on clinical heterogeneity in Huntington disease

    Hirano, M; Iritani, S; Fujishiro, H; Torii, Y; Habuchi, C; Sekiguchi, H; Yoshida, M; Ozaki, N

    BRAIN PATHOLOGY   Vol. 29   page: 95 - 95   2019.2

     More details

  32. The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion

    Iritani Shuji, Torii Youta, Habuchi Chikako, Sekiguchi Hirotaka, Fujishiro Hiroshige, Yoshida Mari, Go Yasuhiro, Iriki Astushi, Isoda Masaki, Ozaki Norio

    INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE   Vol. 71   page: 130 - 139   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijdevneu.2018.09.002

    Web of Science

    PubMed

  33. Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights

    Kushima Itaru, Aleksic Branko, Nakatochi Masahiro, Shimamura Teppei, Okada Takashi, Uno Yota, Morikawa Mako, Ishizuka Kanako, Shiino Tomoko, Kimura Hiroki, Arioka Yuko, Yoshimi Akira, Takasaki Yuto, Yu Yanjie, Nakamura Yukako, Yamamoto Maeri, Iidaka Tetsuya, Iritani Shuji, Inada Toshiya, Ogawa Nanayo, Shishido Emiko, Torii Youta, Kawano Naoko, Omura Yutaka, Yoshikawa Toru, Uchiyama Tokio, Yamamoto Toshimichi, Ikeda Masashi, Hashimoto Ryota, Yamamori Hidenaga, Yasuda Yuka, Someya Toshiyuki, Watanabe Yuichiro, Egawa Jun, Nunokawa Ayako, Itokawa Masanari, Arai Makoto, Miyashita Mitsuhiro, Kobori Akiko, Suzuki Michio, Takahashi Tsutomu, Usami Masahide, Kodaira Masaki, Watanabe Kyota, Sasaki Tsukasa, Kuwabara Hitoshi, Tochigi Mamoru, Nishimura Fumichika, Yamasue Hidenori, Eriguchi Yosuke, Benner Seico, Kojima Masaki, Yassin Walid, Munesue Toshio, Yokoyama Shigeru, Kimura Ryo, Funabiki Yasuko, Kosaka Hirotaka, Ishitobi Makoto, Ohmori Tetsuro, Numata Shusuke, Yoshikawa Takeo, Toyota Tomoko, Yamakawa Kazuhiro, Suzuki Toshimitsu, Inoue Yushi, Nakaoka Kentaro, Goto Yu-ichi, Inagaki Masumi, Hashimoto Naoki, Kusumi Ichiro, Son Shuraku, Murai Toshiya, Ikegame Tempei, Okada Naohiro, Kasai Kiyoto, Kunimoto Shohko, Mori Daisuke, Iwata Nakao, Ozaki Norio

    CELL REPORTS   Vol. 24 ( 11 ) page: 2838 - 2856   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2018.08.022

    Web of Science

    PubMed

  34. The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients

    Marui Tomoyasu, Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Oshima Kenichi, Niizato Kazuhiro, Hayashida Shotaro, Masaki Katsuhisa, Kira Junichi, Ozaki Norio

    ACTA NEUROPSYCHIATRICA   Vol. 30 ( 4 ) page: 232 - 240   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/neu.2018.6

    Web of Science

    PubMed

  35. Brain research and clinical psychiatry: establishment of a psychiatry brain bank in Japan

    Iritani Shuji, Habuchi Chikako, Sekiguchi Hirotaka, Torii Youta

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 3 ) page: 309 - 315   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.80.3.309

    Web of Science

    PubMed

  36. Early diagnosis of Lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [I-123]-metaiodobenzylguanidine cardiac scintigraphy

    Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 72 ( 6 ) page: 423 - 434   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.12651

    Web of Science

    PubMed

  37. Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia

    Morosawa Shunsuke, Iritani Shuji, Fujishiro Hiroshige, Sekiguchi Hirotaka, Torii Youta, Habuchi Chikako, Kuroda Keisuke, Kaibuchi Kozo, Ozaki Norio

    NEUROPEPTIDES   Vol. 62   page: 27 - 35   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.npep.2016.12.010

    Web of Science

    PubMed

  38. An autopsy case of dementia with Lewy bodies clinically diagnosed to have a behavioral variant of frontotemporal dementia

    Sekiguchi Hirotaka, Moriwaki Masatsugu, Iritani Shuji, Habuchi Chikako, Torii Youta, Umeda Kentaro, Fujishiro Hiroshige, Yoshida Mari, Fujita Kiyoshi

    CLINICAL NEUROPATHOLOGY   Vol. 36 ( 1 ) page: 23 - 30   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5414/NP300869

    Web of Science

    PubMed

  39. Catecholaminergic neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia. Reviewed

    Iritani S, Sekiguchi H, Habuchi C, Torii Y, Kuroda K, Kaibuchi K, Ozaki N

    Acta neuropsychiatrica   Vol. 28 ( 2 ) page: 117-23   2016.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/neu.2015.51

    PubMed

  40. Rapid eye movement sleep without atonia may help diagnose Lewy body disease in middle-aged and older patients with somatic symptom disorder. Reviewed

    Munechika T, Fujishiro H, Okuda M, Iwamoto K, Torii Y, Iritani S, Ozaki N

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society     2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/psyg.12181

    PubMed

  41. Immunohistochemical evaluation of the GABAergic neuronal system in the prefrontal cortex of a DISC1 knockout mouse model of schizophrenia. Reviewed

    Umeda K, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N.

    Synapse     2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/syn.21924

  42. Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation. Reviewed

    Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   Vol. 15 ( 3 ) page: 198-203   2015.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/psyg.12105

    PubMed

  43. Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report. Reviewed

    Fujishiro H, Iritani S, Sekiguchi H, Habuchi C, Torii Y, Matsunaga S, Ozaki N, Yoshida M, Fujita K

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society     2015.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/psyg.12128

    PubMed

  44. Effects of aging on the morphologies of Heschl's gyrus and the superior temporal gyrus in schizophrenia: a postmortem study. Reviewed

    Torii Y, Iritani S, Sekiguchi H, Habuchi C, Hagikura M, Arai T, Ikeda K, Akiyama H, Ozaki N

    Schizophrenia research   Vol. 134 ( 2-3 ) page: 137-42   2012.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.schres.2011.10.024

    PubMed

  45. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia. Reviewed

    Sekiguchi H, Iritani S, Habuchi C, Torii Y, Kuroda K, Kaibuchi K, Ozaki N

    Brain research   Vol. 1392   page: 47-53   2011.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainres.2011.03.058

    PubMed

  46. Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy. Reviewed

    Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N

    Journal of the neurological sciences   Vol. 301 ( 1-2 ) page: 77-85   2011.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jns.2010.10.021

    PubMed

  47. Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice. Reviewed

    Iritani S, Sekiguchi H, Habuchi C, Torii Y, Yamada S, Waki Y, Noda Y, Furukawa H, Nabeshima T, Ozaki N

    Neuroscience research   Vol. 68 ( 2 ) page: 125-30   2010.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2010.06.005

    PubMed

  48. 【基本薬の選び方と使い方のコツ ゴールデンスタンダードを使いこなす】 睡眠薬

    鳥居 洋太, 入谷 修司, 尾崎 紀夫

    臨床研修プラクティス   Vol. 6 ( 6 ) page: 38-43   2009.5

     More details

    Authorship:Lead author   Language:Japanese  

  49. "仮面うつ病"に修正型電気けいれん療法が奏効した1例 高齢者の身体表現性障害との関連.

    鳥居洋太, 入谷修司, 尾崎紀夫

    精神科     page: 445-450   2008

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  50. 【症状性(器質性)精神障害の治療ガイドライン】 第1章 全身疾患に精神疾患が由来する病態 10)心筋梗塞に伴ううつ病

    鳥居洋太, 木村宏之, 尾崎紀夫

    精神科治療学   Vol. 21   page: 101-103   2006.10

     More details

    Language:Japanese  

▼display all

Books 2

  1. 日常診療に活かす診療ガイドラインUP-TO-DATE 2016-2017

    鳥居洋太, 尾崎紀夫( Role: Joint author)

    メディカルレビュー社  2016.2 

     More details

    Language:Japanese

  2. 基本薬の選び方と使い方のコツ・13 睡眠薬

    鳥居洋太, 入谷修司, 尾崎紀夫( Role: Joint author)

    文光堂  2013 

     More details

    Language:Japanese

Presentations 7

  1. 統合失調症における神経変性疾患病理所見と認知機能障害との関係

    荒深周生, 鳥居洋太, 入谷修司, 藤城弘樹, 平野光彬, 関口裕孝, 三輪綾子, 羽渕知可子, 吉田眞理, 岩崎靖, 尾崎紀夫

    第16回日本統合失調症学会  2022.3.21 

     More details

    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  2. Immunohistochemical investigation of oligodendrocyte-myelin in a postmortem schizophrenic brain with 22q11.2 deletion

    2021.12.4 

     More details

    Event date: 2021.12

    Language:English   Presentation type:Oral presentation (general)  

  3. 若年で発症した後頭皮質萎縮症の一剖検例

    谷口莉菜, 関口裕孝, 鳥居洋太, 入谷修司, 古泉龍一, 吉田眞理, 岩崎靖, 藤田潔, 尾崎紀夫

    第117回日本精神神経学会学術総会 

     More details

    Event date: 2021.10 - 2021.11

    Language:Japanese   Presentation type:Poster presentation  

  4. Xq22.3-q23重複を有する統合失調症の一剖検例

    鳥居洋太, 入谷修司, 関口裕孝, 羽渕知可子, 藤城弘樹, 久島周, 川島邦裕, 吉田眞理, 尾崎紀夫

    第43回日本生物学的精神医学会  2021.7.14 

     More details

    Event date: 2021.7

    Language:Japanese   Presentation type:Poster presentation  

  5. 心気症状、体感幻覚を呈した 90 歳代女性の一剖検例,

    竹田和弘, 藤城弘樹, 関口裕孝, 鳥居洋太, 三輪綾子, 羽渕知可子, 赤木明生, 吉田眞理, 岩崎靖, 入谷修司, 藤田潔

    第57回名古屋臨床神経病理アカデミー(日本神経病理学会名古屋地方会)  2021.7.10 

     More details

    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. 基底核ドパミントランスポーターの取り込み低下を認めた行動障害型前頭側頭型認知症の一剖検例

    荒深周生, 藤城弘樹, 鳥居洋太, 三輪綾子, 関口裕孝, 羽渕知可子, 矢端博行, 吉田眞理, 岩崎靖, 入谷修司, 川島邦裕

    第57回名古屋臨床神経病理アカデミー(日本神経病理学会名古屋地方会)  2021.7.10 

     More details

    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. 高齢者の抑うつ状態とその理解 Invited

    鳥居洋太

    第63回日本老年医学会学術集会  2021.6.13 

     More details

    Event date: 2021.6 - 2021.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 稀なゲノム変異に着目した統合失調症脳組織表現型の神経病理解析

    Grant number:22K07595  2022.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    鳥居 洋太

      More details

    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    近年、統合失調症発症に強く関わる稀なゲノム変異が同定されつつある。本研究では、発症に関わる稀なゲノム変異が同定された、遺伝的背景が明確な統合失調症死後脳において、分子生物学的情報をもとに、神経細胞やグリア細胞の形態学的変化、神経ネットワークの変化を、免疫組織学的技法を用いて神経病理学的に検討することにより、分子生物学的な背景にもとづいた疾患特異的な脳病理所見を見出す。さらに同様の検証を稀なゲノム変異を伴わない統合失調症死後脳でも行い、得られた脳病理所見と臨床表現型との関連を検討することで組織表現型と臨床表現型との関連を明確化する。
    現在までに稀なゲノム変異を伴う統合失調症死後脳を複数同定しているが、新規症例を増やすため、関連施設において統合失調症を含む精神神経疾患の剖検を継続し、新たに32例の死後脳の蓄積を行った。また、死後脳の臨床情報(発症年齢、罹病期間、臨床症状、臨床経過、薬剤、身体併存疾患、病前の社会適応、家族歴、神経画像など)の収集、蓄積に加え、加齢性変化を中心とした一般神経病理学的評価を15例において行い、これらの情報、所見を以降の解析のためにデータベース化した。得られた死後脳のゲノム解析も継続して行い、稀なゲノム変異を伴う統合失調症死後脳の同定を推し進めた。
    今年度は特に、稀なゲノム変異を伴う統合失調症をはじめとした精神神経疾患死後脳において、アルツハイマー病理などの一般神経病理学的所見と肉眼的な脳形態変化との関連の検討を中心に行った。X染色体に大規模な重複を認める統合失調症、MBD5欠失を伴う統合失調症、DMD欠失を伴う統合失調症などの稀なゲノム変異を伴う統合失調症死後脳において、海馬を含む側頭葉及び前頭葉に特に着目して神経病理学的観察を行い、側脳室の拡大や前頭葉、側頭葉皮質の形態変化を疑う所見(皮質の菲薄化やPatch状の変化など)を認めた。これらの形態学的な変化はアルツハイマー病理など既知の神経変性疾患の病理では説明することが困難であり、統合失調症の病態に関連した変化である可能性が示唆されたが、その特異性に関しては、今後更なる検討を要する。
    2022年度も引き続き例数を増やすために死後脳の収集・蓄積を行うことは目標の一つであったが、2022年は関連施設において、32例の死後脳の収集・蓄積を行うことができた。さらに、これらの症例に関して、順次、生前の臨床診断、臨床経過、病前の社会適応、家族歴、神経画像等の臨床情報の収集及び一般神経病理所見の検討を行い、得られた死後脳のゲノム解析も継続して行った。
    X染色体に大規模な重複を認める統合失調症、MBD5欠失を伴う統合失調症、DMD欠失を伴う統合失調症などの稀なゲノム変異を伴う統合失調症死後脳において、今後検討すべき、形態変化を確認し、一定の推論を得ることができた。これらのことから、概ね順調に進展していると考えられる。
    今年度、検討を中心的に行ったX染色体に大規模な重複を認める統合失調症、MBD5欠失を伴う統合失調症、DMD欠失を伴う統合失調症に加え、22q1.2欠失を伴う統合失調症やGLO1フレームシフトを伴う統合失調症などの稀なゲノム変異を伴う統合失調症について、今年度得られた脳の形態変化に加え、認知機能を含む臨床症状に着目して、免疫組織学的な検討を行い、その背景病態を明確化する

  2. Neuropathological analysis of abnormality in neuronal network formation of schizophrenia based on clinical and genomic information

    Grant number:19K17059  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Torii Youta

      More details

    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Clinical and neuropathological information of postmortem brains of schizophrneia was compiled into a database. The information includes antemortem neuroimaging and long-term clinical course. We focused association between the disease and neurocognitive impairment in the database, and revealed that some of schizophrenia have vulnerability for very mild age-related changes based clinico-neuropathological observations.
    Moreover, we immunostained postmortem brains of schizophrenia with rare variants, and revealed morphological alterations of cerebral cortex, GABAergic system, catecholaminergic system or oligodendrocyte-myelin.

  3. Neuropathological investigation of oligodendrocyte-myelin in postmortem brains of schizophrenia

    Grant number:16K19759  2016.4 - 2019.3

    Torii Youta

      More details

    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    Expression of Myelin Oligodendrocyte Glycoprotein (MOG) and thickness of MOG-positive fiber-like structures were decreased in the superior temporal gyrus and the CA3 of hippocampus of the long-term schizophrenic brains. These findings suggest that oligodendrocyte- myelin abnormalities in these regions may be related to the pathophysiology of schizophrenia.
    In also schizophrenic brains with rare variants (22q11.2 deletion, GLO1 frameshift mutation), morphological alternation of proteins associated with oligodendrocytes-myelin (MOG, Nogo-A) were observed. These findings contribute to understanding of relationship between pathological phenotype and molecular biological backgrounds.

 

Teaching Experience (On-campus) 1

  1. 精神医学

    2021