Updated on 2024/04/03

写真a

 
TAKAMI Hideki
 
Organization
Nagoya University Hospital Center for Postgraduate Clinical Training and Career Development Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 医学博士 ( 2015.3   名古屋大学 ) 

Research Interests 4

  1. 医学教育

  2. liver

  3. pancreas

  4. gasteroenterological surgery

Research Areas 1

  1. Life Science / Digestive surgery  / Pancreas, HBPS

Current Research Project and SDGs 1

  1. EPAによるエキスパート外科医の評価

Education 1

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2012.4 - 2015.3

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    Country: Japan

Professional Memberships 12

  1. 日本外科学会   専門医制度委員、外科専門医修練カリキュラムワーキンググループ委員

    2016.5

  2. 日本肝胆膵外科学会   評議員

  3. 日本外科教育研究会   世話人

  4. 日本消化器外科学会

  5. 日本胃癌学会

  6. 日本腹部救急学会

  7. 日本消化器病学会

  8. 日本膵臓学会

  9. 日本癌治療学会

  10. 日本肝臓学会

  11. 日本臨床外科学会

  12. 日本医学教育学会

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Committee Memberships 1

  1. 日本外科学会専門医制度委員会   委員  

    2018.4   

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    Committee type:Academic society

Awards 1

  1. 最優秀事例賞

    2024.3   日本医療教授システム学会  

 

Papers 116

  1. Evaluation of MAGE-D4 expression in hepatocellular carcinoma in Japanese patients. Reviewed

    Takami H, Kanda M, Oya H, Hibino S, Sugimoto H, Suenaga M, Yamada S, Nishikawa Y, Asai M, Fujii T, Nomoto S, Kodera Y

    Journal of surgical oncology   Vol. 108 ( 8 ) page: 557-62   2013.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jso.23440

    PubMed

  2. Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth <i>via</i> BCL-2-mediated intrinsic apoptosis

    Sasahara, M; Kanda, M; Tanaka, C; Shimizu, D; Umeda, S; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Kodera, Y

    INTERNATIONAL JOURNAL OF CANCER   Vol. 154 ( 7 ) page: 1272 - 1284   2024.4

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  3. Risk Factors for Long-term Body Weight Loss After Proximal Gastrectomy: A Retrospective Analysis.

    Agatsuma Y, Nakanishi K, Tanaka C, Kanda M, Shimizu D, Umeda S, Kurimoto K, Inokawa Y, Takami H, Hattori N, Hayashi M, Nakayama G, Fujiwara M, Kodera Y

    Anticancer research   Vol. 44 ( 4 ) page: 1645 - 1651   2024.4

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    Language:English  

    DOI: 10.21873/anticanres.16963

    PubMed

  4. Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?

    Hirono, S; Higuchi, R; Honda, G; Nara, S; Esaki, M; Gotohda, N; Takami, H; Unno, M; Sugiura, T; Ohtsuka, M; Shimizu, Y; Matsumoto, I; Kin, T; Isayama, H; Hashimoto, D; Seyama, Y; Nagano, H; Hakamada, K; Hirano, S; Nagakawa, Y; Mizuno, S; Takahashi, H; Shibuya, K; Sasanuma, H; Aoki, T; Kohara, Y; Rikiyama, T; Nakamura, M; Endo, I; Sakamoto, Y; Horiguchi, A; Hatori, T; Akita, H; Ueki, T; Idichi, T; Hanada, K; Suzuki, S; Okano, K; Maehira, H; Motoi, F; Fujino, Y; Tanno, S; Yanagisawa, A; Takeyama, Y; Okazaki, K; Satoi, S; Yamaue, H

    ANNALS OF GASTROENTEROLOGICAL SURGERY     2024.3

  5. The shortage of surgeons in Japan: Results of an online survey of qualified teaching hospitals that take part in the surgical training programs for board certification by the Japan Surgical Society

    Takami, H; Kodera, Y; Eguchi, H; Kitago, M; Murotani, K; Hirano, S; Kitagawa, Y; Ikeda, N; Mori, M

    SURGERY TODAY   Vol. 54 ( 1 ) page: 41 - 52   2024.1

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  6. Impact of sarcopenia on biliary drainage during neoadjuvant therapy for pancreatic cancer

    Kataoka, K; Ohno, E; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Takami, H; Maeda, O; Yamaguchi, J; Yokoyama, Y; Ebata, T; Kodera, Y; Kawashima, H

    CLINICAL ENDOSCOPY   Vol. 57 ( 1 ) page: 112 - 121   2024.1

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  7. The degree of satisfaction and level of learning in male and female surgical residents: a nationwide questionnaire survey of graduating residents in Japan

    Hida, K; Hirano, S; Poudel, S; Kurashima, Y; Stefanidis, D; Hashimoto, D; Akiyama, H; Eguchi, S; Fukui, T; Hagiwara, M; Izaki, T; Kawamoto, S; Otomo, Y; Nagai, E; Takami, H; Takeda, Y; Toi, M; Yamaue, H; Yoshida, M; Yoshida, S; Kodera, Y; Saito, M

    SURGERY TODAY   Vol. 53 ( 11 ) page: 1275 - 1285   2023.11

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  8. Predictive impacts of peritoneal washing cytology for surgical resection-intended pancreatic cancer cases: Establishment of planned staging laparoscopy criteria

    Tanaka, N; Takami, H; Hayashi, M; Inokawa, Y; Kurimoto, K; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 11 ) page: 1273 - 1281   2023.11

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  9. Identification of stromal cell-derived factor 4 as a liquid biopsy-based diagnostic marker in solid cancers

    Shinozuka, T; Kanda, M; Shimizu, D; Umeda, S; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 15540   2023.9

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  10. Features of T1 pancreatic cancer and validation of the eighth edition AJCC staging system definition using a Korean-Japanese joint cohort and the SEER database

    Kwon, W; Heo, JS; Han, IW; Kang, CM; Hwang, HK; Kim, SC; Park, SJ; Yoon, YS; Kim, YH; Lim, CS; Lee, SY; Park, T; Takami, H; Watanabe, N; Shimizu, Y; Okuno, M; Yamaue, H; Kawai, M; Seiko, H; Nagakawa, Y; Osakabe, H; Sugiura, T; Toyama, H; Ohtsuka, M; Unno, M; Endo, I; Kitago, M; Jang, JY

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 9 ) page: 1129 - 1140   2023.9

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  11. The preoperative systemic immune-inflammation index is associated with an unfavorable prognosis for patients undergoing curative resection of esophageal squamous cell carcinoma after neoadjuvant therapy

    Obata, Y; Kanda, M; Shimizu, D; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    SURGERY TODAY   Vol. 53 ( 8 ) page: 964 - 972   2023.8

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  12. High Preoperative Serum D-dimer Predicts Unfavorable Survival Outcomes for Pancreatic Cancer Patients

    Otsu, T; Hayashi, M; Takami, H; Inokawa, Y; Tanaka, N; Kurimoto, K; Nakanishi, K; Umeda, S; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    ANTICANCER RESEARCH   Vol. 43 ( 7 ) page: 3173 - 3181   2023.7

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  13. High Preoperative Platelet to Lymphocyte Ratio is Associated with a Greater Risk of Postoperative Complications and Hematogenous Recurrences in Esophageal Squamous Cell Carcinoma Patients Receiving Neoadjuvant Treatment

    Sasahara, M; Kanda, M; Shimizu, D; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Fujiwara, M; Nakayama, G; Kodera, Y

    DIGESTIVE SURGERY   Vol. 40 ( 1-2 ) page: 48 - 57   2023.7

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  14. Albumin-Globulin Ratio Indicates the Survival Outcome of Pancreatic Cancer Cases Who Underwent Preoperative Treatment and Curative Surgical Resection

    Hayashi, M; Kobayashi, D; Takami, H; Inokawa, Y; Tanaka, N; Kurimoto, K; Nakanishi, K; Umeda, S; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL   Vol. 75 ( 5 ) page: 1330 - 1339   2023.5

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  15. Impact of skeletal muscle mass on the prognosis of patients undergoing neoadjuvant chemotherapy for resectable or borderline resectable pancreatic cancer

    Nakajima, H; Yamaguchi, J; Takami, H; Hayashi, M; Kodera, Y; Nishida, Y; Watanabe, N; Onoe, S; Mizuno, T; Yokoyama, Y; Ebata, T

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 5 ) page: 688 - 697   2023.5

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  16. Impact of S-1 adjuvant chemotherapy longer than 6 months on survival in patients with resected pancreatic cancer: a nationwide survey by the Japan Pancreas Society based on real-world data

    Tomimaru, Y; Eguchi, H; Inoue, Y; Nagakawa, Y; Ohba, A; Takami, H; Unno, M; Yamamoto, T; Kawakatsu, S; Hayashi, T; Higuchi, R; Kitagawa, H; Hattori, S; Fujii, T; Hirooka, Y; Igarashi, H; Kitano, M; Kuroki, T; Masamune, A; Shimizu, Y; Tani, M; Tanno, S; Tsuji, Y; Yamaue, H; Satoi, S; Takeyama, Y

    CANCER   Vol. 129 ( 5 ) page: 728 - 739   2023.3

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  17. Proposal of a coagulation score to predict postoperative survival of patients undergoing neoadjuvant therapy followed by subtotal esophagectomy for squamous cell carcinoma of the esophagus.

    Sugiyama, F; Shimizu, D; Kanda, M; Tanaka, C; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 41   page: 448 - 448   2023.2

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  18. Perioperative changes in geriatric functions of elderly patients undergoing surgical resection for gastric cancer.

    Tanaka, C; Kanda, M; Nakanishi, K; Umeda, S; Shimizu, D; Inokawa, Y; Takami, H; Hayashi, M; Nakayama, G; Fujiwara, M; Kodera, Y; Hattori, N

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 41   page: 811 - 811   2023.2

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  19. Prognostic factors of multidisciplinary treatment for borderline resectable and locally advanced pancreatic adenocarcinoma: Results of a dual-center study.

    Kimura, N; Igarashi, T; Yamada, S; Murotani, K; Yoshioka, I; Takami, H; Shibuya, K; Hayashi, M; Tanaka, H; Hirano, K; Watanabe, T; Tanaka, N; Baba, H; Tohmatsu, Y; Sakai, A; Fukasawa, M; Matsui, K; Okumura, T; Kodera, Y; Fujii, T

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 41   page: 680 - 680   2023.2

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  20. Prognostic factors in conversion surgery following nab-paclitaxel with gemcitabine and subsequent chemoradiotherapy for unresectable locally advanced pancreatic cancer: Results of a dual-center study

    Igarashi, T; Yamada, S; Hoshino, Y; Murotani, K; Baba, H; Takami, H; Yoshioka, I; Shibuya, K; Kodera, Y; Fujii, T

    ANNALS OF GASTROENTEROLOGICAL SURGERY   Vol. 7 ( 1 ) page: 157 - 166   2023.1

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  21. Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9

    Yamanaka, M; Hayashi, M; Sonohara, F; Yamada, S; Tanaka, H; Sakai, A; Mii, S; Kobayashi, D; Kurimoto, K; Tanaka, N; Inokawa, Y; Takami, H; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 29 ( 11 ) page: 7180 - 7189   2022.10

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  22. ASO Visual Abstract: Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9

    Yamanaka, M; Hayashi, M; Sonohara, F; Yamada, S; Tanaka, H; Sakai, A; Mii, S; Kobayashi, D; Kurimoto, K; Tanaka, N; Inokawa, Y; Takami, H; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 29 ( 11 ) page: 7192 - 7193   2022.10

  23. Clip-guided local duodenectomy for safe and minimal local resection of nonampullary duodenal neoplasms

    Miwa, T; Yamada, S; Shibuya, K; Hirano, K; Takami, H; Watanabe, T; Hayashi, M; Yoshioka, I; Kodera, Y; Fujii, T

    BMC SURGERY   Vol. 22 ( 1 ) page: 328   2022.8

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  24. Comparison Between FOLFIRINOX and nal-IRI/FL as Second-line Treatment After Gemcitabine Plus Nab-paclitaxel for Pancreatic Cancer br

    Otsu, T; Inokawa, Y; Takami, H; Hayashi, M; Kurimoto, K; Tanaka, N; Tanaka, H; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    ANTICANCER RESEARCH   Vol. 42 ( 8 ) page: 3889 - 3894   2022.8

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  25. Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01)

    Yamaguchi, J; Yokoyama, Y; Fujii, T; Yamada, S; Takami, H; Kawashima, H; Ohno, E; Ishikawa, T; Maeda, O; Ogawa, H; Kodera, Y; Nagino, M; Ebata, T

    ANNALS OF SURGERY   Vol. 275 ( 6 ) page: 1043 - 1049   2022.6

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  26. Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer

    Ichihara, R; Shiraki, Y; Mizutani, Y; Iida, T; Miyai, Y; Esaki, N; Kato, A; Mii, S; Ando, R; Hayashi, M; Takami, H; Fujii, T; Takahashi, M; Enomoto, A

    PATHOLOGY INTERNATIONAL   Vol. 72 ( 3 ) page: 161 - 175   2022.3

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  27. Optimal preoperative multidisciplinary treatment in borderline resectable pancreatic cancer: Results of a dual-center study

    Kimura, N; Yamada, S; Takami, H; Murotani, K; Yoshioka, I; Shibuya, K; Sonohara, F; Hoshino, Y; Hirano, K; Watanabe, T; Baba, H; Mori, K; Miwa, T; Tanaka, H; Kanda, M; Hayashi, M; Matsui, K; Okumura, T; Kodera, Y; Fujii, T

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 40 ( 4 )   2022.2

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  28. Fish bone migration after pancreaticoduodenectomy: Incidence and treatment options

    Takada, Y; Ishikawa, T; Kawashima, H; Mizutani, Y; Ohno, E; Iida, T; Ogawa, H; Hayashi, M; Takami, H; Onoe, S; Ishigami, M

    JOURNAL OF DIGESTIVE DISEASES   Vol. 23 ( 1 ) page: 44 - 49   2022.1

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  29. Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy

    Sunagawa, Y; Hayashi, M; Yamada, S; Tanabe, H; Kurimoto, K; Tanaka, N; Sonohara, F; Inokawa, Y; Takami, H; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    CLINICAL EPIGENETICS   Vol. 13 ( 1 ) page: 172   2021.12

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  30. ISOlation Procedure vs. conventional procedure during Distal Pancreatectomy (ISOP-DP trial): study protocol for a randomized controlled trial

    Okada, K; Kawai, M; Hirono, S; Sho, M; Tani, M; Matsumoto, I; Yamada, S; Amano, R; Toyama, H; Yamashita, YI; Gocho, T; Shibuya, K; Nagai, M; Maehira, H; Kamei, K; Ohira, G; Shirai, Y; Takami, H; Kimura, N; Fukumoto, T; Baba, H; Kodera, Y; Nakao, A; Shimokawa, T; Katsuda, M; Yamaue, H

    TRIALS   Vol. 22 ( 1 ) page: 633   2021.9

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  31. 「《緊急特別企画》パンデミック状況下における外科診療と教育」パンデミック下における外科卒前教育の工夫 Invited Reviewed

    高見 秀樹, 小寺 泰弘

    日本外科学会雑誌   Vol. 122 ( 5 ) page: 575 - 577   2021.9

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    Authorship:Lead author   Language:Japanese  

  32. 各領域から考える外科専門医制度 再掲 外科専門医のグランドデザイン Invited Reviewed

    小寺 泰弘, 高見 秀樹, 北川 雄光, 池田 徳彦, 平野 聡, 森 正樹

    日本外科学会雑誌   Vol. 122 ( 5 ) page: 510 - 512   2021.9

  33. A Possible Definition of Oligometastasis in Pancreatic Cancer and Associated Survival Outcomes

    Yamanaka, M; Hayashi, M; Yamada, S; Sonohara, F; Takami, H; Inokawa, Y; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANTICANCER RESEARCH   Vol. 41 ( 8 ) page: 3933 - 3940   2021.8

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  34. Double common bile duct associated with pancreaticobiliary maljunction

    Yamada, K; Ishikawa, T; Ohno, E; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yoshikawa, M; Takami, H; Inokawa, Y; Uchida, H; Kawashima, H; Fujishiro, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 655 - 661   2021.8

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  35. High Serum Uric Acid Levels Could Be a Risk Factor of Hepatocellular Carcinoma Recurrences

    Hayashi, M; Yamada, S; Tanabe, H; Takami, H; Inokawa, Y; Sonohara, F; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL   Vol. 73 ( 6 ) page: 996 - 1003   2021.7

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  36. Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma

    Nakagawa, N; Sonohara, F; Tanaka, K; Sunagawa, Y; Inokawa, Y; Takami, H; Hayashi, M; Yamada, S; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ONCOLOGY LETTERS   Vol. 22 ( 1 ) page: 538   2021.7

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  37. The impact of early tumor shrinkage on conversion surgery and the survival in patients with unresectable locally advanced pancreatic cancer

    Takano, N; Yamada, S; Sonohara, F; Inokawa, Y; Takami, H; Hayashi, M; Koike, M; Fujii, T; Kodera, Y

    SURGERY TODAY   Vol. 51 ( 7 ) page: 1099 - 1107   2021.7

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  38. <i>miR</i>-<i>23b</i>-<i>3p</i> Plays an Oncogenic Role in Hepatocellular Carcinoma

    Hayashi, M; Yamada, S; Kurimoto, K; Tanabe, H; Hirabayashi, S; Sonohara, F; Inokawa, Y; Takami, H; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 28 ( 6 ) page: 3416 - 3426   2021.6

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  39. Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma

    Hayashi, M; Yamada, S; Takano, N; Okamura, Y; Takami, H; Inokawa, Y; Sonohara, F; Tanaka, N; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    IN VIVO   Vol. 35 ( 3 ) page: 1749 - 1760   2021.5

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  40. Conversion surgery in patients with pancreatic cancer and peritoneal metastasis

    Yamada, S; Fujii, T; Yamamoto, T; Takami, H; Yoshioka, I; Yamaki, S; Sonohara, F; Shibuya, K; Motoi, F; Hirano, S; Murakami, Y; Inoue, H; Hayashi, M; Hashimoto, D; Murotani, K; Kitayama, J; Ishikawa, H; Kodera, Y; Sekimoto, M; Satoi, S

    JOURNAL OF GASTROINTESTINAL ONCOLOGY   Vol. 12 ( Suppl 1 ) page: S110 - S117   2021.4

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  41. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma

    Suenaga, M; Fujii, T; Yamada, S; Hayashi, M; Shinjo, K; Takami, H; Niwa, Y; Sonohara, F; Shimizu, D; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kondo, Y; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 28 ( 4 ) page: 2277 - 2286   2021.4

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  42. Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue

    Sunagawa, Y; Yamada, S; Sonohara, F; Kurimoto, K; Tanaka, N; Suzuki, Y; Inokawa, Y; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 6016   2021.3

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  43. Age-Related Differences in the Prognosis of Pancreatic Cancer According to Perioperative Systemic Therapy

    Sonohara, F; Yamada, S; Kurimoto, K; Inokawa, Y; Takami, H; Hayashi, M; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Fujii, T; Kodera, Y

    PANCREAS   Vol. 50 ( 1 ) page: 37 - 46   2021.1

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  44. Perioperative assessment of indocyanine green elimination rate accurately predicts postoperative liver failure in patients undergoing hepatectomy

    Sunagawa, Y; Yamada, S; Kato, Y; Sonohara, F; Takami, H; Inokawa, Y; Hayashi, M; Nakayama, G; Koike, M; Kodera, Y

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 28 ( 1 ) page: 86 - 94   2021.1

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  45. Pancreatic Fat and Body Composition Measurements by Computed Tomography are Associated with Pancreatic Fistula After Pancreatectomy

    Tanaka, K; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 28 ( 1 ) page: 530 - 538   2021.1

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  46. Optimal Preoperative Multidisciplinary Treatment in Borderline Resectable Pancreatic Cancer

    Kimura, N; Yamada, S; Takami, H; Murotani, K; Yoshioka, I; Shibuya, K; Sonohara, F; Hoshino, Y; Hirano, K; Watanabe, T; Baba, H; Mori, K; Miwa, T; Kanda, M; Hayashi, M; Matsui, K; Okumura, T; Kodera, Y; Fujii, T

    CANCERS   Vol. 13 ( 1 )   2021.1

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  47. Multicenter randomized phase II trial of prophylactic right-half dissection of superior mesenteric artery nerve plexus in pancreatoduodenectomy for pancreatic head cancer

    Yamada, S; Satoi, S; Takami, H; Yamamoto, T; Yoshioka, I; Sonohara, F; Yamaki, S; Shibuya, K; Hayashi, M; Hashimoto, D; Ando, M; Murotani, K; Sekimoto, M; Kodera, Y; Fujii, T

    ANNALS OF GASTROENTEROLOGICAL SURGERY   Vol. 5 ( 1 ) page: 111 - 118   2021.1

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  48. 外科系新専門医制度のあるべきグランドデザイン 新専門医制度における外科研修の現状報告 Invited Reviewed

    小寺泰弘、高見秀樹

    日本外科学会雑誌   Vol. 122 ( 1 ) page: 74 - 76   2021.1

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    Authorship:Last author  

  49. Necessity for craniospinal irradiation of germinoma with positive cytology without spinal lesion on MR imaging-A controversy

    Kanamori, M; Takami, H; Suzuki, T; Tominaga, T; Kurihara, J; Tanaka, S; Hatazaki, S; Nagane, M; Matsuda, M; Yoshino, A; Natsumeda, M; Yamaoka, M; Kagawa, N; Akiyama, Y; Fukai, J; Negoto, T; Shibahara, I; Tanaka, K; Inoue, A; Mase, M; Tomita, T; Kuga, D; Kijima, N; Fukami, T; Nakahara, Y; Natsume, A; Yoshimoto, K; Keino, D; Tokuyama, T; Asano, K; Ujifuku, K; Abe, H; Nakada, M; Matsuda, KI; Arakawa, Y; Ikeda, N; Narita, Y; Shinojima, N; Kambe, A; Nonaka, M; Izumoto, S; Kawanishi, Y; Kanaya, K; Nomura, S; Nakajima, K; Yamamoto, S; Terashima, K; Ichimura, K; Nishikawa, R

    NEURO-ONCOLOGY ADVANCES   Vol. 3 ( 1 ) page: vdab086   2021.1

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  50. Problem-Based Learning in Child and Adolescent Psychiatry: A Perspective from Japan

    Iwatsuki, J; Kondo, T; Takahashi, N; Takami, H; Nishigori, H; Bustos-Villalobos, I; Aleksic, B; Kasuya, H; Ban, NO; Yagi, T; Skokauskas, N

    ADVANCES IN MEDICAL EDUCATION AND PRACTICE   Vol. 12   page: 1329 - 1335   2021

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  51. Phase I/IIstudy of adding intraperitoneal paclitaxel in patients with pancreatic cancer and peritoneal metastasis

    Yamada, S; Fujii, T; Yamamoto, T; Takami, H; Yoshioka, ; Yamaki, S; Sonohara, F; Shibuya, K; Motoi, F; Hirano, S; Murakami, Y; Inoue, H; Hayashi, M; Murotani, K; Kitayama, J; Ishikawa, H; Kodera, Y; Sekimoto, M; Satoi, S

    BRITISH JOURNAL OF SURGERY   Vol. 107 ( 13 ) page: 1811 - 1817   2020.12

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  52. Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue

    Nakagawa, N; Tanaka, K; Sonohara, F; Kandimalla, R; Sunagawa, Y; Inokawa, Y; Takami, H; Hayashi, M; Yamada, S; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANTICANCER RESEARCH   Vol. 40 ( 12 ) page: 6665 - 6676   2020.12

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  53. Is there disparity between regions and facilities in surgical resident training in Japan? Insights from a national survey

    Hashimoto, D; Poudel, S; Hirano, S; Kurashima, Y; Akiyama, H; Eguchi, S; Fukui, T; Hagiwara, M; Hida, K; Izaki, T; Iwase, H; Kawamoto, S; Otomo, Y; Nagai, E; Saito, M; Takami, H; Takeda, Y; MasakazuToi; Yamaue, H; Yoshida, M; Yoshida, S; Ohki, T; Kodera, Y

    SURGERY TODAY   Vol. 50 ( 12 ) page: 1585 - 1593   2020.12

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  54. An outcome analysis of predictive factors for portal or splenic vein thrombosis after distal pancreatectomy

    Tanaka, N; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    SURGERY TODAY   Vol. 50 ( 10 ) page: 1282 - 1289   2020.10

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  55. Are graduating residents sufficiently competent? Results of a national gap analysis survey of program directors and graduating residents in Japan

    Poudel, S; Hirano, S; Kurashima, Y; Stefanidis, D; Akiyama, H; Eguchi, S; Fukui, T; Hagiwara, M; Hashimoto, D; Hida, K; Izaki, T; Iwase, H; Kawamoto, S; Otomo, Y; Nagai, E; Saito, M; Takami, H; Takeda, Y; Toi, M; Yamaue, H; Yoshida, M; Yoshida, S; Kodera, Y

    SURGERY TODAY   Vol. 50 ( 9 ) page: 995 - 1001   2020.9

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  56. Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy

    Yamada, S; Yokoyama, Y; Sonohara, F; Yamaguchi, J; Takami, H; Hayashi, M; Onoe, S; Fujii, T; Nagino, M; Kodera, Y

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 27 ( 8 ) page: 487 - 495   2020.8

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  57. The impact of cancer stem cell markers in the tissues of pancreatic ductal adenocarcinoma for prognosis after surgical resections

    Inokawa, Y; Yamada, S; Hayashi, M; Sunagawa, Y; Sonohara, F; Takami, H; Hattori, N; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    CANCER RESEARCH   Vol. 80 ( 16 )   2020.8

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  58. Novel Prognostic Implications of DUPAN-2 in the Era of Initial Systemic Therapy for Pancreatic Cancer

    Sunagawa, Y; Yamada, S; Sato, Y; Morimoto, D; Sonohara, F; Takami, H; Inokawa, Y; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 6 ) page: 2081 - 2089   2020.6

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  59. 【パンデミック下の医学教育-現在進行形の実践報告-】オンライン授業 オンライン臨床実習にも転用可能なオンラインPBLの実践報告 Reviewed

    近藤 猛, 高見 秀樹, 錦織 宏

    医学教育   Vol. 51 ( 3 ) page: 276 - 278   2020.6

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  60. Characteristics of Lung Metastasis as an Initial Recurrence Pattern After Curative Resection of Pancreatic Cancer

    Morimoto, D; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    PANCREAS   Vol. 49 ( 5 ) page: 699 - 705   2020.5

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  61. Clinical impact of additional therapy for residual pancreatic cancer

    Yamada, S; Sonohara, F; Tashiro, M; Murotani, K; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujii, T; Kodera, Y

    SURGERY TODAY   Vol. 50 ( 5 ) page: 440 - 448   2020.5

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  62. Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

    Sonohara, F; Yamada, S; Takeda, S; Hayashi, M; Suenaga, M; Sunagawa, Y; Tashiro, M; Takami, H; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANTICANCER RESEARCH   Vol. 40 ( 4 ) page: 1843 - 1853   2020.4

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  63. 【実践!手術が上達するトレーニング法-Off the Job Trainingの最新動向】手術シミュレーションの実際 バーチャル・リアリティ手術シミュレータ(VRS)の意義と今後の展望 Invited

    藤原 道隆, 林 雄一郎, 高見 秀樹, 田中 千恵, 森 健策, 小寺 泰弘

    臨床外科   Vol. 75 ( 4 ) page: 476 - 482   2020.4

  64. Clinical Implications of Naples Prognostic Score in Patients with Resected Pancreatic Cancer

    Nakagawa, N; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 3 ) page: 887 - 895   2020.3

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  65. Effects of duration of initial treatment on postoperative complications in pancreatic cancer

    Takeda, N; Yamada, S; Takami, H; Sonohara, F; Hayashi, M; Yoshioka, I; Shibuya, K; Matsui, K; Hirano, K; Watanabe, T; Tohmatsu, Y; Kimura, N; Hojo, S; Sawada, S; Okumura, T; Nagata, T; Kodera, Y; Fujii, T

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 38 ( 4 )   2020.2

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  66. Predictive value of the modified systemic inflammation score in patients undergoing curative resection of squamous cell carcinoma of the esophagus

    Kanda, M; Koike, M; Shimizu, D; Tanaka, C; Kobayashi, D; Sonohara, F; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 38 ( 4 )   2020.2

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  67. Multicenter phase I/II study of intravenous gemcitabine plus nab-paclitaxel combined with intraperitoneal paclitaxel for pancreatic ductal adenocarcinoma patients with peritoneal metastasis

    Yamada, S; Fujii, T; Yamamoto, T; Takami, H; Yoshioka, I; Yamaki, S; Sonohara, F; Shibuya, K; Motoi, F; Hirano, S; Murakami, Y; Inoue, H; Hayashi, M; Kodera, Y; Sekimoto, M; Satoi, S

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 38 ( 4 )   2020.2

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  68. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma

    Suenaga, M; Fujii, T; Yamada, S; Hayashi, M; Shinjo, K; Takami, H; Niwa, Y; Sonohara, F; Shimizu, D; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kondo, Y; Kodera, Y

    PANCREAS   Vol. 48 ( 10 ) page: 1528 - 1528   2019.11

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  69. Comparison of non-invasive liver reserve and fibrosis models: Implications for surgery and prognosis for hepatocellular carcinoma

    Sonohara, F; Yamada, S; Tanaka, N; Tashiro, M; Sunagawa, Y; Morimoto, D; Tanaka, H; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    HEPATOLOGY RESEARCH   Vol. 49 ( 11 ) page: 1305 - 1315   2019.11

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  70. A snapshot of surgical resident training in Japan: results of a national-level needs assessment survey

    Poudel, S; Hirano, S; Kurashima, Y; Stefanidis, D; Akiyama, H; Eguchi, S; Fukui, T; Hagiwara, M; Hashimoto, D; Hida, K; Izaki, T; Iwase, H; Kawamoto, S; Otomo, Y; Nagai, E; Saito, M; Takami, H; Takeda, Y; Toi, M; Yamaue, H; Yoshida, M; Yoshida, S; Kodera, Y

    SURGERY TODAY   Vol. 49 ( 10 ) page: 870 - 876   2019.10

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  71. Novel implications of combined arterial resection for locally advanced pancreatic cancer in the era of newer chemo-regimens

    Sonohara, F; Yamada, S; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    EJSO   Vol. 45 ( 10 ) page: 1895 - 1900   2019.10

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  72. Biological and conditional factors should be included when defining criteria for resectability for patients with pancreatic cancer.

    Kato Y, Yamada S, Tashiro M, Sonohara F, Takami H, Hayashi M, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Koike M, Fujiwara M, Kodera Y

    HPB : the official journal of the International Hepato Pancreato Biliary Association   Vol. 21 ( 9 ) page: 1211 - 1218   2019.9

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    DOI: 10.1016/j.hpb.2019.01.012

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  73. 新専門医制度の開始により見えてきたその現状と課題 外科専門医に求められるコンピテンシー Invited Reviewed

    高見秀樹、小寺泰弘

    日本外科学会雑誌   Vol. 120 ( 5 ) page: 598 - 600   2019.9

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  74. Functions of FRAS1 as a driver gene of liver metastasis from gastric cancer analyzed by the genome editing technology

    Umeda, S; Kanda, M; Tanaka, H; Sonohara, F; Takami, H; Hattori, N; Hayashi, M; Tanaka, C; Kobayashi, D; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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  75. Effects of duration of initial treatment on postoperative complications in pancreatic cancer

    Yamada, S; Takami, H; Sonohara, F; Hayashi, M; Fujii, T; Kodera, Y

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 26 ( 6 ) page: 235 - 241   2019.6

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  76. Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study

    Takano, N; Yamada, S; Hirakawa, A; Yokoyama, Y; Kawashima, H; Maeda, O; Okada, T; Ohno, E; Yamaguchi, J; Ishikawa, T; Sonohara, F; Suenaga, M; Takami, H; Hayashi, M; Niwa, Y; Hirooka, Y; Ito, Y; Naganawa, S; Ando, Y; Nagino, M; Goto, H; Fuji, T; Kodera, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 233 - 239   2019.5

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  77. Perioperative and prognostic implication of albumin-bilirubin-TNM score in Child-Pugh class A hepatocellular carcinoma

    Sonohara Fuminori, Yamada Suguru, Tanaka Nobutake, Suenaga Masaya, Takami Hideki, Hayashi Masamichi, Niwa Yukiko, Sugimoto Hiroyuki, Hattori Norifumi, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    ANNALS OF GASTROENTEROLOGICAL SURGERY   Vol. 3 ( 1 ) page: 65 - 74   2019.1

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    DOI: 10.1002/ags3.12212

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  78. 外科医を育てる![第18回] 名古屋大学消化器外科2で取り組む卒前・卒後外科教育 Invited

    高見秀樹、藤原道隆、小寺泰弘

    外科   Vol. 80 ( 13 ) page: 1351 - 1353   2018.12

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  79. Dual-center randomized clinical trial exploring the optimal duration of antimicrobial prophylaxis in patients undergoing pancreaticoduodenectomy following biliary drainage

    Yamamoto Tomohisa, Satoi Sohei, Fujii Tsutomu, Yamada Suguru, Yanagimoto Hiroaki, Yamaki So, Takami Hideki, Hirooka Satoshi, Kosaka Hisashi, Kotsuka Masaya, Miyara Takayuki, Kodera Yasuhiro

    ANNALS OF GASTROENTEROLOGICAL SURGERY   Vol. 2 ( 6 ) page: 442 - 450   2018.11

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    DOI: 10.1002/ags3.12209

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  80. Prognostic Impact of Portal System Invasion in Pancreatic Cancer Based on Image Classification

    Morimoto Daishi, Yamada Suguru, Murotani Kenta, Sonohara Fuminori, Takami Hideki, Suenaga Masaya, Hayashi Masamichi, Niwa Yukiko, Tashiro Mitsuru, Hattori Norifumi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Kodera Yasuhiro

    PANCREAS   Vol. 47 ( 10 ) page: 1350 - 1356   2018.11

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    DOI: 10.1097/MPA.0000000000001186

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  81. Clinical Impact of Neoadjuvant Therapy on Nutritional Status in Pancreatic Cancer

    Tashiro Mitsuru, Yamada Suguru, Sonohara Fuminori, Takami Hideki, Suenaga Masaya, Hayashi Masamichi, Niwa Yukiko, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 25 ( 11 ) page: 3365 - 3371   2018.10

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    DOI: 10.1245/s10434-018-6699-8

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  82. Comparison of the Survival Outcomes of Pancreatic Cancer and Intraductal Papillary Mucinous Neoplasms.

    Yamada S, Fujii T, Hirakawa A, Takami H, Suenaga M, Hayashi M, Niwa Y, Hattori N, Iwata N, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Pancreas   Vol. 47 ( 8 ) page: 974 - 979   2018.9

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    DOI: 10.1097/MPA.0000000000001110

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  83. Impact of the Controlling Nutritional Status Score on the Prognosis After Curative Resection of Pancreatic Ductal Adenocarcinoma

    Kato Yoshiyasu, Yamada Suguru, Suenaga Masaya, Takami Hideki, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    PANCREAS   Vol. 47 ( 7 ) page: 823 - 829   2018.8

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    DOI: 10.1097/MPA.0000000000001105

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  84. Randomized Phase II Trial of CapOX plus Bevacizumab and CapIRI plus Bevacizumab as First-Line Treatment for Japanese Patients with Metastatic Colorectal Cancer (CCOG-1201 Study)

    Nakayama Goro, Mitsuma Ayako, Sunagawa Yuki, Ishigure Kiyoshi, Yokoyama Hiroyuki, Matsui Takanori, Nakayama Hiroshi, Nakata Kazuhiko, Ishiyama Akiharu, Asada Takahiro, Umeda Shinichi, Ezaka Kazuhiro, Hattori Norifumi, Takami Hideki, Kobayashi Daisuke, Tanaka Chie, Kanda Mitsuro, Yamada Suguru, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Murotani Kenta, Ando Yuichi, Kodera Yasuhiro

    ONCOLOGIST   Vol. 23 ( 8 ) page: 919 - 927   2018.8

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    DOI: 10.1634/theoncologist.2017-0640

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  85. Molecular surgical margin analysis of pancreatic cancers

    Hayashi, M; Yamada, S; Tanabe, H; Kato, Y; Tanaka, K; Tashiro, M; Tanaka, H; Asano, T; Takami, H; Suenaga, M; Niwa, Y; Kodera, Y

    CANCER RESEARCH   Vol. 78 ( 13 )   2018.7

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  86. Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer

    Tanaka Nobutake, Yamada Suguru, Sonohara Fuminori, Suenaga Masaya, Hayashi Masamichi, Takami Hideki, Niwa Yukiko, Hattori Norifumi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Kodera Yasuhiro

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9846   2018.6

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    DOI: 10.1038/s41598-018-28253-9

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  87. IDENTIFICATION OF MOLECULES DRIVING HEPATIC METASTASIS FORMATION OF GASTRIC CANCER CELLS

    Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Suenaga Masaya, Takami Hideki, Hattori Norifumi, Niwa Yukiko, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    GUT   Vol. 67   page: A5 - A5   2018.6

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    DOI: 10.1136/gutjnl-2018-IDDFabstracts.12

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  88. Significance of Lysyl oxidase-like 2 gene expression on the epithelial-mesenchymal status of hepatocellular carcinoma

    Ninomiya Go, Yamada Suguru, Hayashi Masamichi, Takeda Shigeomi, Suenaga Masaya, Takami Hideki, Kanda Mitsuro, Iwata Naoki, Niwa Yukiko, Tanaka Chie, Kobayashi Daisuke, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    ONCOLOGY REPORTS   Vol. 39 ( 6 ) page: 2664 - 2672   2018.6

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    DOI: 10.3892/or.2018.6349

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  89. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer

    Yamada Suguru, Fujii Tsutomu, Yokoyama Yukihiro, Kawashima Hiroki, Maeda Osamu, Suzuki Kojiro, Okada Tohru, Ono Eizaburo, Yamaguchi Junpei, Takano Nao, Takami Hideki, Hayashi Masamichi, Niwa Yukiko, Hirooka Yoshiki, Ito Yoshiyuki, Naganawa Shinji, Ando Yuichi, Nagino Masato, Goto Hidemi, Kodera Yasuhiro

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   Vol. 81 ( 5 ) page: 815 - 821   2018.5

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    DOI: 10.1007/s00280-018-3554-3

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  90. Identification of a novel molecule target for the diagnosis, prediction, and treatment of hepatic metastasis of gastric cancer.

    Kanda Mitsuro, Tanaka Haruyoshi, Miwa Takashi, Kobayashi Daisuke, Tanaka Chie, Takami Hideki, Hayashi Masamichi, Iwata Naoki, Niwa Yukiko, Yamada Suguru, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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    DOI: 10.1200/JCO.2018.36.4_suppl.53

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  91. Clinical implication of nutrition for neoadjuvant therapy and impact of nutritional support in pancreatic cancer.

    Tashiro Mitsuru, Yamada Suguru, Fujii Tsutomu, Hattori Norifumi, Takami Hideki, Suenaga Masaya, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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    DOI: 10.1200/JCO.2018.36.4_suppl.416

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  92. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer.

    Yamada Suguru, Fujii Tsutomu, Takano Nao, Takami Hideki, Suenaga Masaya, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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    DOI: 10.1200/JCO.2018.36.4_suppl.523

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  93. A series of seton techniques involving "top-down therapy" for patients with Crohn's disease who initially presented with perianal fistulas

    Saigusa Naoto, Saigusa Jun-ichi, Shinozaki Masaru, Yokoyama Tadashi, Yokoi Yoshihiro, Takami Hideki, Miyahara Ryoji, Yokoyama Yasuhisa

    JOURNAL OF THE ANUS RECTUM AND COLON   Vol. 2 ( 4 ) page: 122 - 129   2018

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    DOI: 10.23922/jarc.2017-044

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  94. Evaluation and proposal of novel resectability criteria for pancreatic cancer established by the Japan Pancreas Society. Reviewed

    Yamada S, Fujii T, Takami H, Hayashi M, Iwata N, Kanda M, Tanaka C, Sugimoto H, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Surgery   Vol. 162 ( 4 ) page: 784-791   2017.10

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    DOI: 10.1016/j.surg.2017.04.023

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  95. Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma. Reviewed

    Umeda S, Kanda M, Sugimoto H, Tanaka H, Hayashi M, Yamada S, Fujii T, Takami H, Niwa Y, Iwata N, Tanaka C, Kobayashi D, Fujiwara M, Kodera Y

    BMC cancer   Vol. 17 ( 1 ) page: 610   2017.9

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    DOI: 10.1186/s12885-017-3629-2

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  96. Involvement of the immunoregulator MZB1 in progression of gastric cancer

    Tanaka Y., Kanda M., Tanaka C., Kobayashi D., Tanaka H., Takami H., Hayashi M., Iwata N., Niwa Y., Yamada S., Nakayama G., Sugimoto H., Koike M., Fujiwara M., Kodera Y.

    ANNALS OF ONCOLOGY   Vol. 28   page: .   2017.9

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  97. Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma. Reviewed

    Asano T, Yamada S, Fuchs BC, Takami H, Hayashi M, Sugimoto H, Fujii T, Tanabe KK, Kodera Y

    International journal of oncology   Vol. 50 ( 5 ) page: 1647-1654   2017.5

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    DOI: 10.3892/ijo.2017.3937

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  98. Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer. Reviewed

    Inaoka K, Kanda M, Uda H, Tanaka Y, Tanaka C, Kobayashi D, Takami H, Iwata N, Hayashi M, Niwa Y, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y

    World journal of gastroenterology   Vol. 23 ( 14 ) page: 2519-2526   2017.4

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    DOI: 10.3748/wjg.v23.i14.2519

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  99. GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer. Reviewed

    Shimizu D, Kanda M, Tanaka H, Kobayashi D, Tanaka C, Hayashi M, Iwata N, Niwa Y, Takami H, Yamada S, Fujii T, Nakayama G, Fujiwara M, Kodera Y

    Scientific reports   Vol. 7   page: 42089   2017.2

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    DOI: 10.1038/srep42089

    PubMed

  100. Clinical impact of sarcopenia on prognosis in pancreatic ductal adenocarcinoma.

    Ninomiya, G; Fujii, T; Yamada, S; Asano, T; Takano, N; Takami, H; Iwata, N; Kanda, M; Niwa, Y; Hayashi, M; Kobayashi, D; Tanaka, C; Nakayama, G; Sugimoto, H; Fujiwara, M; Koike, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  101. Inverse probability of treatment weighting analysis of upfront surgery versus neoadjuvant chemoradiotherapy followed by surgery for pancreatic adenocarcinoma with arterial abutment.

    Fujii, T; Yamada, S; Murotani, K; Takami, H; Hayashi, M; Kanda, M; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  102. Clinical implication of inflammation-based prognostic score and perioperative nutrition control in pancreatic cancer.

    Takano, N; Yamada, S; Fujii, T; Tashiro, M; Tanaka, N; Morimoto, D; Ninomiya, G; Niwa, Y; Takami, H; Iwata, N; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  103. Proposal of the Coagulation Score as a Predictor for Short-Term and Long-Term Outcomes of Patients with Resectable Gastric Cancer

    Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Mizuno Akira, Tanaka Yuri, Takami Hideki, Iwata Naoki, Hayashi Masamichi, Niwa Yukiko, Yamada Suguru, Fujii Tsutomu, Sugimoto Hiroyuki, Murotani Kenta, Fujiwara Michitaka, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 24 ( 2 ) page: 502 - 509   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-016-5544-1

    Web of Science

    PubMed

  104. Clinical benefits of neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreatic head: an observational study using inverse probability of treatment weighting.

    Fujii T, Satoi S, Yamada S, Murotani K, Yanagimoto H, Takami H, Yamamoto T, Kanda M, Yamaki S, Hirooka S, Kon M, Kodera Y

    Journal of gastroenterology   Vol. 52 ( 1 ) page: 81-93   2017.1

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    DOI: 10.1007/s00535-016-1217-x

    PubMed

  105. PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma. Reviewed

    Kurimoto K, Hayashi M, Guerrero-Preston R, Koike M, Kanda M, Hirabayashi S, Tanabe H, Takano N, Iwata N, Niwa Y, Takami H, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Fujii T, Fujiwara M, Kodera Y

    Epigenetics   Vol. 12 ( 10 ) page: 865-874   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15592294.2017.1365207

    PubMed

  106. Nutritional predictors for postoperative short-term and long-term outcomes of patients with gastric cancer.

    Kanda M, Mizuno A, Tanaka C, Kobayashi D, Fujiwara M, Iwata N, Hayashi M, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Takami H, Niwa Y, Murotani K, Kodera Y

    Medicine   Vol. 95 ( 24 ) page: e3781   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000003781

    PubMed

  107. Tumor Infiltrative Pattern Predicts Sites of Recurrence After Curative Gastrectomy for Stages 2 and 3 Gastric Cancer.

    Kanda M, Mizuno A, Fujii T, Shimoyama Y, Yamada S, Tanaka C, Kobayashi D, Koike M, Iwata N, Niwa Y, Hayashi M, Takami H, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 23 ( 6 ) page: 1934-40   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-016-5102-x

    PubMed

  108. NRAGE promotes the malignant phenotype of hepatocellular carcinoma.

    Shimizu D, Kanda M, Sugimoto H, Sueoka S, Takami H, Ezaka K, Tanaka Y, Hashimoto R, Okamura Y, Iwata N, Tanaka C, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y

    Oncology letters   Vol. 11 ( 3 ) page: 1847-1854   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2016.4120

    PubMed

  109. Function and diagnostic value of Anosmin-1 in gastric cancer progression.

    Kanda M, Shimizu D, Fujii T, Sueoka S, Tanaka Y, Ezaka K, Takami H, Tanaka H, Hashimoto R, Iwata N, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    International journal of cancer   Vol. 138 ( 3 ) page: 721-30   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.29803

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  110. Short-term outcomes after conventional transthoracic esophagectomy.

    Niwa Y, Koike M, Hattori M, Iwata N, Takami H, Hayashi M, Kanda M, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y

    Nagoya journal of medical science   Vol. 78 ( 1 ) page: 69-78   2016.2

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    PubMed

  111. The Prognostic Relevance of Subcarinal Lymph Node Dissection in Esophageal Squamous Cell Carcinoma.

    Niwa Y, Koike M, Hattori M, Iwata N, Takami H, Hayashi M, Tanaka C, Kobayashi D, Kanda M, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 23 ( 2 ) page: 611-8   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-015-4819-2

    PubMed

  112. Modified Blumgart Suturing Technique for Remnant Closure After Distal Pancreatectomy: a Propensity Score-Matched Analysis.

    Fujii T, Yamada S, Murotani K, Sugimoto H, Hattori M, Kanda M, Takami H, Nakayama G, Nomoto S, Fujiwara M, Nakao A, Kodera Y

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract   Vol. 20 ( 2 ) page: 374-84   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11605-015-2980-3

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  113. Adherens junctions associated protein 1 serves as a predictor of recurrence of squamous cell carcinoma of the esophagus.

    Tanaka H, Kanda M, Koike M, Iwata N, Shimizu D, Ezaka K, Sueoka S, Tanaka Y, Takami H, Hashimoto R, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    International journal of oncology   Vol. 47 ( 5 ) page: 1811-8   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijo.2015.3167

    PubMed

  114. Significance of the Splenic Vein and Its Branches in Pancreatoduodenectomy with Resection of the Portal Vein System.

    Hattori M, Fujii T, Yamada S, Inokawa Y, Suenaga M, Takami H, Kanda M, Sugimoto H, Nomoto S, Murotani K, Nakao A, Kodera Y

    Digestive surgery   Vol. 32 ( 5 ) page: 382-8   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000438797

    PubMed

  115. Preservation of the pyloric ring confers little benefit in patients undergoing total pancreatectomy.

    Takami H, Fujii T, Kanda M, Suenaga M, Yamamura K, Kodera Y

    World journal of surgery   Vol. 38 ( 7 ) page: 1807-13   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00268-014-2469-3

    PubMed

  116. 【膵癌に対する術前治療をめぐって】膵癌の術前化学放射線療法における血管浸潤部の術前画像と病理所見の対比 Invited

    高見 秀樹, 藤井 努, 神田 光郎, 末永 雅也, 小寺 泰弘

    胆と膵   Vol. 35 ( 1 ) page: 81 - 86   2014.1

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Presentations 13

  1. 大腸癌肝転移術後早期再発症例の検討

    高見秀樹,杉本博行,中山吾郎,神田光郎,岩田直樹,小林大介,田中千恵,山田 豪,藤井 努,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    日本消化器病学会東海支部例会第121回例会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  2. 肝細胞癌におけるMAGE-D4発現に関する検討

    高見秀樹,神田光郎,大屋久晴,日比野壮貴,清水 大,山田 豪,藤井 努,杉本博行,野本周嗣,小寺泰弘

    第69回日本消化器外科学会総会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:郡山   Country:Japan  

  3. 膵癌に対する術前化学放射線療法の周術期栄養状態に関する検討The influence of neoadjuvant chemoradiation therapy on perioperative nutritional status in patients with pancreatic cancer

    高見秀樹,藤井 努,神田光郎,末永雅也,山田 豪,杉本博行,野本周嗣,小寺泰弘 Hideki Takami, Tsutomu Fujii, Mitsuro Kanda, Masaya Suenaga, Suguru Yamada, Hiroyuki Sugimoto, Shuji Nomoto, Yasuhiro Kodera

    第26回日本肝胆膵外科学会・学術集会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:和歌山   Country:Japan  

  4. RESERVATION OF THE PYLORIC RING CONFERS LITTLE BENEFIT IN PATIENTS UNDFERGOING TOTAL PANCREATECTOMY International conference

    Hideki Takami, Tsutomu Fujii, Mitsuro Kanda, Masaya Suenaga, Kazuo Yamamura, Yasuhiro kodera

    International Congress and the Third IASGO Postgraduate Course 2014 

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    Event date: 2014.6

    Language:English   Presentation type:Poster presentation  

    Country:Russian Federation  

  5. 術後急性期における炎症指数を用いた膵瘻重症化予測法の検討

    高見秀樹,藤井 努,神田光郎,末永雅也,服部正嗣,山田 豪,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    第114回日本外科学会定期学術集会 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  6. 膵全摘術における幽門輪温存の意義〜術後合併症および長期栄養状態の検討〜

    高見秀樹,藤井努,神田光郎,山村和生,末永雅也,山田豪,丹羽由紀子,服部正嗣,杉本博行,野本周嗣,竹田伸,小寺泰弘

    第40回日本膵切研究会 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:高松   Country:Japan  

  7. 高齢者に対する肝細胞癌手術の治療戦略

    高見秀樹,杉本博行,猪川祥邦,山村和生,神田光郎,山田豪,藤井努,野本周嗣,竹田伸,小寺泰弘

    第68回日本消化器外科学会総会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  8. PRESERVATION OF THE PYLORIC RING CONFERS LITTLE BENEFIT IN PATIENTS UNDERGOING TOTAL PANCREATECTOMY. International conference

    Hideki Takami, Tsutomu Fujii, Mitsuro Kanda, Masaya Suenaga, Kazuo Yamamura, Yoshikuni Inokawa, Suguru Yamada, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Yasuhiro Kodera

    ESMO 15th World Congress on Gastrointestinal Cancer 

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    Event date: 2013.7

    Language:English   Presentation type:Poster presentation  

    Country:Spain  

  9. ラジオ波焼灼術後のneedle tract seeding切除後長期生存を得た肝細胞癌の2例

    高見秀樹,杉本博行,猪川祥邦,菱田光洋,山村和生,神田光郎,山田豪,藤井努,野本周嗣,竹田伸,小寺泰弘

    第25回日本肝胆膵外科学会・学術集会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宇都宮   Country:Japan  

  10. 超音波内視鏡下生検でのimplantationが原因と思われる膵solid-pseudopapillary neoplasm再発の1切除例

    高見秀樹,谷口健次(小牧市民病院)

    第24回日本肝胆膵外科学会・学術集会 

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    Event date: 2012.5 - 2012.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  11. 膀胱浸潤を伴うS状結腸癌・直腸癌に対する代用膀胱による尿路再建術の検討

    高見秀樹,横山裕之,谷口健次,越川克己,望月能成,猪川祥邦,武内大,橋本良二,山本優子,田中克仁,森憲彦,末永裕之(小牧市民病院)

    第72回日本臨床外科学会総会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  12. 胃癌術後9年目に発症した異時性孤立性肺転移の1切除例

    高見秀樹,越川克己,和田応樹,谷口健次,望月能成,横山裕之,猪川祥邦,武内大,橋本良二,山本優子,田中克仁,森憲彦,末永裕之,内山美佳(小牧市民病院)

    第280回東海外科学会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  13. 透析患者の手術例の検討

    高見秀樹,三輪高也,稲岡健一,村井俊文,福岡伴樹,武内有城,佐野正明,山村義孝(名古屋記念病院)

    第110回日本外科学会定期学術集会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. DX of surgical training using multimodal VR technology

    Grant number:22H03310  2022.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  2. EPAを用いたエキスパート外科医育成のための評価基準の開発

    Grant number:22K12883  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    高見 秀樹, 小寺 泰弘, 錦織 宏, 藤原 道隆

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    Authorship:Principal investigator 

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    本研究では、エキスパート外科医(特に日本肝胆膵外科学会の高度技能専門医や日本内視鏡外科学会の技術認定のような専門性の高い、高次専門医)に必要な資質・能力(コンピテンシー)の評価方法として“ EPA (Entrustable Professional Activities) ”の概念を用いて評価する方法を立案する。Delphi法を用いてエキスパート外科医を目指す修練医を指導する指導者間の意識統合を行い、エキスパート外科医に必要なコンピテンシーを明らかにする。そしてそのコンピテンシーを評価するためのEPAを用いた評価方法を考案し、その評価法の妥当性・信頼性および実現可能性についても検証する。
    本研究では、エキスパート外科医(特に日本肝胆膵外科学会の高度技能専門医や日本内視鏡外科学会の技術認定のような専門性の高い、高次専門医)に必要な資質・能力(コンピテンシー)の評価方法として“ EPA (Entrustable Professional Activities) ”の概念を用いて評価する方法を立案するものである。Delphi法を用いてエキスパート外科医を目指す修練医を指導する指導者間の意識統合を行い、エキスパート外科医に必要なコンピテンシーを明らかにしたのち、そのコンピテンシーを評価するためのEPAを用いた評価方法を考案し、その評価法の妥当性・信頼性および実現可能性についても検証することを計画している。
    2022年度はこれまでの先行研究および海外で使用されるコンピテンシーについてドキュメント調査を行った。具体的には文献検索や情報収集を行い、エキスパート外科医に必要なコンピテンシーを抽出し、研究協力者を募って、初期リスト作りのための協議を行ってきた。またエキスパート外科医の実務の調査として診療や実際の手術について、自施設のみならず他施設での実態についても調査・見学し、その状況について分析をおこなった。一方、教育分野においてEPAは比較的新しい概念であり、その解釈には十分な理解が必要と感がられるが、2022年7月26日に医学教育振興財団が主催する指導者フォーラムにおいて、EPAを提唱したOlle ten Cate氏の講演が開催されたため、その内容を聴講した。全国の医学教育学者ともEPAの在り方については直接議論を重ねることもできた。
    本来であれば初期リストの作成からDelphi Roundまで開始する予定であったがそこまで至ることができなかった。この理由としては初期リスト作りに難航したことが一番の理由である。ドキュメントを収集・分析したが、本研究のようなエキスパート外科医に求められるコンピテンシーについて言及した研究は多くはない。そのため慎重に議論を重ねる必要があると考えたため、2022年度は前述のような情報収集や議論に時間をかけることとなった。その点でやや遅れていると判断したが、肝心かなめの初期リストさえ完成すればアンケートの発出および収集にはそれほど時間を要さないため、次年度以降でも十分研究の進行は間に合うと考えている。
    まずはエキスパート外科医に必要なコンピテンシーについて初期リストの完成を行う。初期リストについてはエキスパート外科医および医学教育学に精通した医師と繰り返し協議して過不足のないものを完成させる。初期リストが完成したら全国のエキスパート外科医にむけてアンケートの発出を行う予定である。アンケート発出先としては日本肝胆膵外科学会高度技能専門医や日本内視鏡外科学会の技術認定医を想定しており、これらの医師の選定はおおむね終了している。アンケート回答者には謝金を渡す予定であるが、その方法については現在検討中である。アンケートが回収できたのちにDelphi Roundを行う。Delphi roundは5件法のLikert scale(1=絶対に除外すべきである、2=除外したほうがよい、3=どちらとも言えない、4=含めたほうがよい、5=絶対に含めるべきである)で回答を求め75%以上のパネルが4あるいは5と回答する、もしくは平均4以上かつ標準偏差1未満を合意基準として3ラウンド行い、その結果を分析して最終案を作成する。自由記載内容についてはテーマ分析し、協議した上で次回のリストに加える。このコンピテンシーの最終案をもとにEPA評価表の初期リストを完成させ、再度Delphi法を行ってエキスパート外科医に必要なEPA評価表を作成する予定である。
    また本評価表の普及のため、評価表使用施設の指導医へのFaculty Development(FD)を行う。ここでは評価表の作成のみならず、学習者評価についての講義やロールプレイ、グループディスカッションなど行う。その後評価表の妥当性・信頼性・実現可能性について検証していく予定である。

  3. 膵癌腹膜播種に対する新規バイオマーカー: 臨床応用に向けた検証と新規治療法開発

    Grant number:21K07188  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    末永 雅也, 林 真路, 高見 秀樹, 猪川 祥邦

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    Authorship:Coinvestigator(s) 

    膵癌の腹膜播種は予後を規定する重要な因子である。近年、膵癌手術患者の腹腔腔洗浄液
    中から高感度測定法を用いて検出される腫瘍DNAが腹膜播種の有望なバイオマーカーとなる可能性を報告した。本研究ではこの手法の臨床応用を目的として、前向き臨床試験によって有用性を検証する。さらに、本研究で得られた腹腔洗浄液を用いて、将来的な治療ターゲットに応用可能な新規バイオマーカーの探索する。
    膵癌の腹膜播種は予後を規定する重要な因子である。近年、膵癌手術患者の腹腔腔洗浄液
    中から検出される腫瘍DNAをperitoneal washing tumor DNA(ptDNA)と名付け、ptDNAが既存の腹腔洗浄細胞診を補い膵癌腹膜播種における有望なバイオマーカーとなることを報告した。本研究ではptDNAの臨床応用を目的として、測定手法の改良をおこなうとともに、前向き臨床試験によって膵癌腹膜播種予測におけるptDNAのバイオマーカーとしての有用性を検証する。さらに、本研究では臨床試験によって得られた腹腔洗浄液を用いてエクソソームRNA等を用いた新規バイオマーカーの探索を行い、将来的な治療ターゲットに応用可能な候補因子を選定する。
    膵癌腹膜播種に対する新規バイオマーカーの開発のために多施設共同研究を立案し、2021年9月までに全国から13施設を募り、2021年11月15日の中央倫理審査の承認の後に、2022年1月より症例集積を開始した (UMIN000045828) 。本研究では根治切除術を施行予定の膵癌患者を対象とし、症例集積は2年で180症例を予定している。登録症例においては新規バイオマーカーの開発のために腹腔洗浄液検体を50 mL回収し、従来法による腹腔洗浄細胞診結果やその他の臨床病理学的因子と検討することで、腹腔洗浄細胞診を補完する遺伝子学的バイオマーカー開発を目指す。
    2022年3月31日現在、135例の症例登録(うち、非切除等による中止例が22例) の症例が集まっており、概ね予定通りの症例登録が進んでいる。登録症例の臨床データについてはElectoronic data capturingで適宜集積が進んでおり、腹腔洗浄液検体の輸送も75例まで完了していることから次年度にはバイオマーカー解析を開始する。
    多施設共同研究において予定通り症例登録は進み、着実に臨床データと研究検体も集積しつつある。
    非切除による中止症例が一定頻度で出現していることから、プロトコール改正をおこない症例集積期間を2024年3月に延長する。その後は主要評価項目のptDNA、付随研究のエクソソームRNA等のバイオマーカーの実験を進め、症例集積後3年の観察期間後にデータ解析をおこなう。

  4. 腫瘍由来エクソソームによる膵癌マルチオミクス・プロファイリングの挑戦と臨床応用

    Grant number:19K09214  2019.4 - 2021.3

    科学研究費助成事業  基盤研究(C)

    山田 豪, 小寺 泰弘, 室谷 健太, 園原 史訓, 高見 秀樹, 林 真路

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    Authorship:Coinvestigator(s) 

    本研究では初発再発形式ごとに血液検体からエクソソームを抽出し、トランスクリプトーム解析および、プロテオミクス解析による「エクソソーム・マルチオミクス解析」を行う。次に、サブタイプ分類確立の礎となるEpithelial to mesenchymal transition (EMT) statusを判別する「EMTマルチオミクス・パネル」を開発する。さらに、膵癌組織検体と血液においてEMTマルチオミクス・パネルを解析し、膵癌の再発・進展形式を鋭敏に予測しうる癌細胞由来エクソソームの遺伝子・分子群を絞り込む。最終的には、生物統計学的処理により「膵癌マルチオミクス・プロファイル」の新たな開発をめざす。
    膵癌は局所進展タイプと遠隔転移タイプに大きく二分され、さらにサブタイプ分類されるというのが我々の仮説である。術前に組織採取が困難な膵癌ではリキッドバイオプシーが有用であるため、本研究では血液検体から抽出したエクソソームの情報を基に膵癌サブタイプ分類の確立と臨床応用を目的とした。まずは膵癌切除例の術前血液検体から初発再発形式ごとに検体を選択し、エクソソームを抽出した上で核酸分子に対する網羅的なmRNA解析およびmicroRNA解析を行い、その他の分子の中で脂質は炎症・免疫応答・癌の進展等のシグナル伝達において重要な役割を果たすことからエクソソーム中のリピドーム解析を行うこととした。
    当科で治療を受けた膵癌患者の治療前血液検体を用い、エクソソーム中に含まれるmicroRNAの網羅的解析を行った。経過中肝転移・肺転移・腹膜播種等の遠隔転移を起こした症例が10例、局所再発が5例、無再発例が5例含まれていた。エクソソームを抽出後、BGISEQ-500を用いた解析をしたところ、各再発・無再発形式によって群分けした場合のmiRNA発現で差を認めたものを抽出し、解析を行った。次にエクソソーム内の脂質に注目し、リピドーム解析を行った(shotgun法およびtargeted lipidomics assay)。その結果、各再発・無再発形式により特徴的なリピドームの高低が抽出され、特にあるリピドームクラスについては無再発群と再発群でP=0.057と有意差はないものの含有量の違いを認める結果であった。さらにエクソソーム中のmRNAについて次世代シーケンサーによる網羅的解析を行い、再発・無再発形式別での血液由来エクソソーム内における発現差異解析を行った。

  5. Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue

    Grant number:18K16303  2018.4 - 2020.3

    Grant-in-Aid for Early-Career Scientists

    Takami Hideki

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    We found using high-throughput sequencing that seven candidate circular RNAs (circRNAs) were downregulated in HCC. The expression of these circRNA were examined by quantitative PCR in 233 sets of HCC and matched background normal liver tissues, and correlation between candidate circRNA expression and prognosis was evaluated. The results of quantitative PCR showed that expression of five circRNAs were significantly lower in HCC than background normal liver tissues. Kaplan-Meier analysis revealed that low expression of circRNAs hsa_circ_0001020, hsa_circ_0036683, and hsa_circ_0058087 was associated with poor recurrence free survival (RFS) and overall survival (OS) in HCC. Additionally, multivariate analysis revealed that low hsa_circ_0036683 expression was a significant independent prognostic factor for inferior RFS and OS. There was no significant association between the expression of these circRNAs and hepatitis B/C status or cirrhosis.

  6. Exploration of tailored treatment based on type classification of pancreatic cancer using exosome

    Grant number:16K10590  2016.4 - 2019.3

    YAMADA Suguru

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    Authorship:Coinvestigator(s) 

    Exosomal micro RNAs(exo-miRNAs) could reflect the epithelial to mesenchymal transition(EMT) status of the original parental cell. This study aimed to identify exo-miRNAs related to EMT status of pancreatic cancer(PC). Comprehensive miRNA-expression profiles of exosomes in culture media of PC cell lines were analyzed through genome-wide microarray technology. Discovered miRNAs were analyzed to investigate their clinical implication with TCGA dataset, cell lines, and clinical samples. We prioritized 291 exo-miRNAs differentially expressed between epithelial type and mesenchymal type and selected the miRNAs. Next, the analysis of TCGA dataset revealed candidate miRNAs. In addition, quantitative PCR analysis indicated miRNAs as the EMT markers. Finally, we investigated the expression of miRNAs in serum. We have discovered novel exo-miRNAs associated with EMT status of PC. Our findings may be step on the way to establish less-invasive biomarkers to contribute personalized medicine for PC.

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Teaching Experience (On-campus) 25

  1. PBL

    2020

  2. 臨床実習Ⅱ 外科ユニット

    2023

  3. PBLまとめ

    2023

  4. 膵臓外科

    2023

  5. 基本的臨床技能実習 直腸診

    2023

  6. 選択特別講義 消化器外科入門

    2023

  7. 選択特別講義 外科手技の継承

    2023

  8. 臨床実習Ⅰ 外科ユニット

    2023

  9. 基本的臨床技能実習 直腸診

    2022

  10. PBL

    2022

  11. 膵臓外科

    2022

  12. 選択特別講義 消化器外科入門

    2022

  13. 選択特別講義 外科手技の継承

    2022

  14. 臨床実習Ⅰ 外科ユニット

    2022

  15. 臨床実習Ⅱ 外科ユニット

    2022

  16. 基本的臨床技能実習 直腸診

    2021

  17. 選択特別講義 消化器外科入門

    2021

  18. 臨床実習II 外科ユニット

    2021

  19. 臨床実習Ⅰ 外科ユニット

    2021

  20. 系統講義 消化器 膵臓外科

    2021

  21. PBL

    2021

  22. 基本的臨床技能実習 直腸診

    2020

  23. 選択特別講義 消化器外科入門

    2020

  24. 臨床実習II 消化器外科2

    2020

  25. 臨床実習Ⅰ 外科ユニット

    2020

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Social Contribution 9

  1. 新潟大学臨床研修指導医講習会講師

    Role(s):Lecturer

    2024.3

  2. Japanese Surgeons as Educators coarseファシリテーター

    Role(s):Lecturer

    2024.3

  3. 名大ネットワーク指導医講習会ファシリテーター

    Role(s):Lecturer

    2023.11

  4. Japanese Surgeons as Educators coarseファシリテーター

    Role(s):Lecturer

    2023.10

  5. Japanese Surgeons as Educators coarseファシリテーター

    Role(s):Lecturer

    2023.5

  6. 現場で働く指導医のための医学教育学入門基礎編 講師

    Role(s):Lecturer

    2023.4 - 2024.3

  7. ICLSコースディレクター

    Role(s):Planner

  8. 日本専門医機構

    Role(s):Organizing member

  9. 日本外科学会 専門医制度委員会

    Role(s):Organizing member

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