Faculty Profiles - OHKA Fumiharu

Papers - OHKA Fumiharu

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Molecular insights and the role of 18F-FDG-PET/CT in the diagnosis of spinal gliomas.

Nagashima Y, Nishimura Y, Eguchi K, Yamaguchi J, Haimoto S, Ohka F, Motomura K, Abe T, Matsuo M, Tsukamoto E, Hara M, Saito R

Acta neurochirurgica Vol. 166 ( 1 ) page： 154 2024.3

Awake Craniotomy for Gliomas in the Non-Dominant Right Hemisphere: A Comprehensive Review

Mamadaliev, DM; Saito, R; Motomura, K; Ohka, F; Scalia, G; Umana, GE; Conti, A; Chaurasia, B

CANCERS Vol. 16 ( 6 ) 2024.3

Endoscopic debulking canalization for optic pathway glioma with obstructive hydrocephalus

Takeuchi, K; Ohka, F; Nagata, Y; Ito, E; Harada, H; Saito, R

CHILDS NERVOUS SYSTEM Vol. 39 ( 12 ) page： 3421 - 3425 2023.12

Fifteen-Fraction Radiosurgery Followed by Reduced-Dose Whole-Brain Irradiation With a Total Biologically Effective Dose of >90-100 Gy for a Locally Invasive Brain Metastasis From Lung Adenocarcinoma With a High Dissemination Potential

Ohtakara, K; Ohka, F; Tanahashi, K; Yamada, T; Suzuki, K

CUREUS JOURNAL OF MEDICAL SCIENCE Vol. 15 ( 11 ) page： e49596 2023.11

ESTABLISHMENT OF ORGANOID MODELS OF PATIENT-DERIVED GH-PRODUCING PITUITARY ADENOMA

Maeda, S; Ohka, F; Kanamori, F; Okumura, Y; Takeuchi, K; Nagata, Y; Motomura, K; Yamaguchi, J; Kibe, Y; Harada, H; Shimizu, H; Takido, Y; Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

INTRA-OPERATIVE ANALYSES OF GENETIC ALTERATIONS IN THE CENTRAL NERVOUS SYSTEM TUMORS USING RAPID QUANTITATIVE PCR DEVICE

Ohka, F; Maeda, S; Yamaguchi, J; Shimizu, H; Motomura, K; Takeuchi, K; Nagata, Y; Nishikawa, T; Kibe, Y; Takido, Y; Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

IMAGING FEATURES AND CONSIDERATION OF PROGRESSION PATTERN OF DIFFUSE HEMISPHERIC GLIOMAS, H3 G34-MUTANT

Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Shimizu, H; Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

GLIOBLASTOMA, IDH-WILDTYPE WITHOUT KEY MOLECULAR FEATURES

Saito, R; Motomura, K; Ohka, F; Yamaguchi, J; Maeda, S; Nishikawa, T; Mizutani, K; Kibe, Y; Shimizu, H; Takido, Y

NEURO-ONCOLOGY Vol. 25 2023.11

Development of machine learning models for predicting unfavorable functional outcomes from preoperative data in patients with chronic subdural hematomas

Fuse, Y; Nagashima, Y; Nishiwaki, H; Ohka, F; Muramatsu, Y; Araki, Y; Nishimura, Y; Ienaga, J; Nagatani, T; Seki, Y; Watanabe, K; Ohno, K; Saito, R

SCIENTIFIC REPORTS Vol. 13 ( 1 ) page： 16997 2023.10

Predictive factors of post-operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping

Motomura, K; Kawamura, A; Ohka, F; Aoki, K; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Saito, R

JOURNAL OF NEUROPSYCHOLOGY 2023.9

TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation

Suzuki, MM; Iijima, K; Ogami, K; Shinjo, K; Murofushi, Y; Xie, JQ; Wang, XB; Kitano, Y; Mamiya, A; Kibe, Y; Nishimura, T; Ohka, F; Saito, R; Sato, S; Kobayashi, J; Yao, R; Miyata, K; Kataoka, K; Suzuki, HI; Kondo, Y

NATURE COMMUNICATIONS Vol. 14 ( 1 ) page： 4521 2023.8

Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

Takahashi, H; Yasui, T; Hirano, M; Shinjo, K; Miyazaki, Y; Shinoda, W; Hasegawa, T; Natsume, A; Kitano, Y; Ida, M; Zhang, M; Shimada, T; Paisrisarn, P; Zhu, ZT; Ohka, F; Aoki, K; Rahong, S; Nagashima, K; Yanagida, T; Baba, Y

BIOSENSORS & BIOELECTRONICS Vol. 234 page： 115318 2023.8

Latest classification of ependymoma in the molecular era and advances in its treatment: a review

Yamaguchi, J; Ohka, F; Motomura, K; Saito, R

JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 53 ( 8 ) page： 653 - 663 2023.7

Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases.

Ohno M, Haimoto S, Tsukushi S, Hosoda W, Ohka F, Saito R

Journal of neurosurgery. Case lessons Vol. 6 ( 3 ) 2023.7

Efficacy and safety of bevacizumab, irinotecan, and temozolomide combination for relapsed or refractory pediatric central nervous system embryonal tumor: a single-institution study

Shiba, Y; Motomura, K; Taniguchi, R; Kurimoto, M; Mizutani, K; Ohka, F; Aoki, K; Ito, E; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Nakashima, T; Suzuki, H; Muramatsu, H; Takahashi, Y; Saito, R

JOURNAL OF NEUROSURGERY-PEDIATRICS Vol. 31 ( 6 ) page： 624 - 632 2023.6

Rapid detection of the MYD88 L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma

Yamaguchi, J; Ohka, F; Kitano, Y; Maeda, S; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Hattori, H; Tsujiuchi, T; Motomura, A; Nishikawa, T; Kibe, Y; Shinjo, K; Kondo, Y; Saito, R

CANCER SCIENCE Vol. 114 ( 6 ) page： 2544 - 2551 2023.6

Clinical characteristics and radiological features of glioblastoma, IDH-wildtype, grade 4 with histologically lower-grade gliomas

Motomura, K; Kibe, Y; Ohka, F; Aoki, K; Yamaguchi, J; Saito, R

BRAIN TUMOR PATHOLOGY Vol. 40 ( 2 ) page： 48 - 55 2023.4

Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas

Nishikawa, T; Ohka, F; Aoki, K; Suzuki, H; Motomura, K; Yamaguchi, J; Maeda, S; Kibe, Y; Shimizu, H; Natsume, A; Innan, H; Saito, R

BRAIN TUMOR PATHOLOGY Vol. 40 ( 2 ) page： 85 - 92 2023.4

CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma

Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Kano, T; Wakabayashi, K; Oyama, H; Kurahashi, S; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Natsume, A; Saito, R

CANCER MEDICINE Vol. 12 ( 6 ) page： 7116 - 7126 2023.3

Identification of therapeutic targets exhibiting synthetic lethality with IDH1 inhibitor using the CRISPR/Cas9 system

Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Natsume, A; Saito, R

CANCER SCIENCE Vol. 114 page： 1460 - 1460 2023.2

Intra-operative analysis of genetic alterations in brain tumor using rapid quantitative PCR device

Ohka, F; Maeda, S; Yamaguchi, J; Motomura, K; Saito, R

CANCER SCIENCE Vol. 114 page： 1818 - 1818 2023.2

All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an ex Vivo Brain Tumor Model

Chattrairat, K; Yasui, T; Suzuki, S; Natsume, A; Nagashima, K; Iida, M; Zhang, M; Shimada, T; Kato, A; Aoki, K; Ohka, F; Yamazaki, S; Yanagida, T; Baba, Y

ACS NANO Vol. 17 ( 3 ) page： 2235 - 2244 2023.1

Imaging features of localized IDH wild-type histologically diffuse astrocytomas: a single-institution case series

Kibe, Y; Motomura, K; Ohka, F; Aoki, K; Shimizu, H; Yamaguchi, J; Nishikawa, T; Saito, R

SCIENTIFIC REPORTS Vol. 13 ( 1 ) page： 23 2023.1

CLINICAL AND MOLECULAR FEATURES OF GLIOBLASTOMA, IDH-WILDTYPE ARISING IN THE SETTING OF LI FRAUMENI SYNDROME

Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Nishikawa, T; Mizutani, K; Shimizu, H; Hiramatsu, T; Suzuki, K; Saito, R

NEURO-ONCOLOGY Vol. 24 page： 154 - 154 2022.11

ROLE OF CD79B Y196 MUTATION IN PCNSL AS A POTENT PREDICTIVE MARKER FOR FAVORABLE RESPONSE TO R-MPV TREATMENT AND DEVELOPMENT OF RAPID ALL-IN-ONE GENOTYPING SYSTEM FOR MOLECULAR MARKERS OF PCNSL

Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Saito, R

NEURO-ONCOLOGY Vol. 24 page： 18 - 18 2022.11

IDENTIFICATION OF A NOVEL THERAPEUTIC TARGET THAT IS SYNTHETICALLY LETHAL WITH MUTANT IDH INHIBITOR IN GLIOMA USING THE CRISPR/CAS9 GENOME EDITING TECHNOLOGY

Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Motomura, K; Kibe, Y; Natsume, A; Saito, R

NEURO-ONCOLOGY Vol. 24 page： 107 - 107 2022.11

Endoscopic Trans-Mini-Cylinder Biopsy for Intraparenchymal Brain Lesions

Takeuchi, K; Ohka, F; Nagata, Y; Maeda, S; Tanahashi, K; Araki, Y; Yamamoto, T; Sasaki, H; Mizuno, A; Harada, H; Saito, R

WORLD NEUROSURGERY Vol. 167 page： E1147 - E1153 2022.11

Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving tocilizumab: illustrative case.

Ohno M, Kuramitsu S, Iwakoshi A, Yamaguchi J, Ohka F, Saito R

Journal of neurosurgery. Case lessons Vol. 4 ( 6 ) 2022.8

Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review

Kibe, Y; Tanahashi, K; Ohtakara, K; Okumura, Y; Ohka, F; Takeuchi, K; Nagata, Y; Motomura, K; Akahori, S; Mizuno, A; Sasaki, H; Shimizu, H; Yamaguchi, J; Nishikawa, T; Yokota, K; Saito, R

BMC NEUROLOGY Vol. 22 ( 1 ) page： 223 2022.6

Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

Nagashima, Y; Nishimura, Y; Eguchi, K; Yamaguchi, J; Haimoto, S; Ohka, F; Takayasu, M; Saito, R

NEUROSPINE Vol. 19 ( 2 ) page： 262 - 271 2022.6

Supratotal Resection of Gliomas With Awake Brain Mapping: Maximal Tumor Resection Preserving Motor, Language, and Neurocognitive Functions

Motomura, K; Ohka, F; Aoki, K; Saito, R

FRONTIERS IN NEUROLOGY Vol. 13 page： 874826 2022.5

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

Iwama, S; Kobayashi, T; Yasuda, Y; Okuji, T; Ito, M; Ando, M; Zhou, X; Yamagami, A; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Wakahara, K; Yokota, K; Kato, M; Nishio, N; Tanaka, C; Miyata, K; Ogura, A; Ito, T; Sawada, T; Shimokata, T; Niimi, K; Ohka, F; Ishigami, M; Gotoh, M; Hashimoto, N; Saito, R; Kiyoi, H; Kajiyama, H; Ando, Y; Hibi, H; Sone, M; Akiyama, M; Kodera, Y; Arima, H

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Vol. 107 ( 4 ) page： E1620 - E1630 2022.3

Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

Nishikawa, T; Watanabe, R; Kitano, Y; Yamamichi, A; Motomura, K; Ohka, F; Aoki, K; Hirano, M; Kato, A; Yamaguchi, J; Maeda, S; Kibe, Y; Saito, R; Wakabayashi, T; Kato, Y; Sato, S; Ogino, T; Natsume, A; Ito, I

BRAIN TUMOR PATHOLOGY Vol. 39 ( 1 ) page： 14 - 24 2022.1

(11)C-methionine- and (18)F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high (18)F-FDG uptake: A case report.

Tanahashi K, Hirano M, Chalise L, Tsugawa T, Okumura Y, Hase T, Ohka F, Motomura K, Takeuchi K, Nagata Y, Nakahara N, Hashimoto N, Saito R

Surgical neurology international Vol. 13 page： 372 2022

Dural Arteriovenous Fistula Mimicking a Brain Tumor on Methionine-positron Emission Tomography: A Case Report.

Hanyu T, Nishihori M, Izumi T, Motomura K, Ohka F, Goto S, Araki Y, Yokoyama K, Uda K, Saito R

NMC case report journal Vol. 9 page： 289 - 294 2022

Newly established patient-derived organoid model of intracranial meningioma

Yamazaki, S; Ohka, F; Hirano, M; Shiraki, Y; Motomura, K; Tanahashi, K; Tsujiuchi, T; Motomura, A; Aoki, K; Shinjo, K; Murofushi, Y; Kitano, Y; Maeda, S; Kato, A; Shimizu, H; Yamaguchi, J; Adilijiang, A; Wakabayashi, T; Saito, R; Enomoto, A; Kondo, Y; Natsume, A

NEURO-ONCOLOGY Vol. 23 ( 11 ) page： 1936 - 1948 2021.11

Intraoperative seizure outcome of levetiracetam combined with perampanel therapy in patients with glioma undergoing awake brain surgery

Motomura, K; Chalise, L; Shimizu, H; Yamaguchi, J; Nishikawa, T; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Wakabayashi, T; Natsume, A

JOURNAL OF NEUROSURGERY Vol. 135 ( 4 ) page： 998 - 1007 2021.10

Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

Nagashima, Y; Nishimura, Y; Ohka, F; Eguchi, K; Aoki, K; Ito, H; Nishii, T; Oyama, T; Hara, M; Kitano, Y; Masaki, H; Wakabayashi, T; Natsume, A

CELLS Vol. 10 ( 10 ) 2021.10

Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

Aoki, K; Suzuki, H; Yamamoto, T; Yamamoto, KN; Maeda, S; Okuno, Y; Ranjit, M; Motomura, K; Ohka, F; Tanahashi, K; Hirano, M; Nishikawa, T; Shimizu, H; Kitano, Y; Yamaguchi, J; Yamazaki, S; Nakamura, H; Takahashi, M; Narita, Y; Nakada, M; Deguchi, S; Mizoguchi, M; Momii, Y; Muragaki, Y; Abe, T; Akimoto, J; Wakabayashi, T; Saito, R; Ogawa, S; Haeno, H; Natsume, A

CANCER RESEARCH Vol. 81 ( 18 ) page： 4861 - 4873 2021.9

Long-term survival in patients with primary intracranial germ cell tumors treated with surgery, platinum-based chemotherapy, and radiotherapy: a single-institution study.

Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Yoshida J, Natsume A, Wakabayashi T

Journal of neurosurgery Vol. 135 ( 2 ) page： 449 - 457 2021.8

Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

Motomura, K; Chalise, L; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Nishikawa, T; Yamaguchi, J; Shimizu, H; Wakabayashi, T; Saito, R

JOURNAL OF NEURO-ONCOLOGY Vol. 153 ( 2 ) page： 361 - 372 2021.6

Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds

Kitano, Y; Aoki, K; Ohka, F; Yamazaki, S; Motomura, K; Tanahashi, K; Hirano, M; Naganawa, T; Iida, M; Shiraki, Y; Nishikawa, T; Shimizu, H; Yamaguchi, J; Maeda, S; Suzuki, H; Wakabayashi, T; Baba, Y; Yasui, T; Natsume, A

ACS APPLIED MATERIALS & INTERFACES Vol. 13 ( 15 ) page： 17316 - 17329 2021.4

Expression of programmed cell death ligand-1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B-cell lymphoma of the central nervous system.

Tsuyuki Y, Ishikawa E, Kohno K, Shimada K, Ohka F, Suzuki Y, Mabuchi S, Satou A, Takahara T, Kato S, Miyagi S, Ozawa H, Kawano T, Takagi Y, Hiraga J, Wakabayashi T, Nakamura S

Neuropathology : official journal of the Japanese Society of Neuropathology Vol. 41 ( 2 ) page： 99 - 108 2021.4

Trautmann-focused mastoidectomy for a simple, safe presigmoid approach: technical note.

Tanahashi K, Uda K, Araki Y, Takeuchi K, Choo J, Chalise L, Motomura K, Ohka F, Wakabayashi T, Natsume A

Journal of neurosurgery Vol. 134 ( 3 ) page： 843 - 847 2021.3

Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

Fukuoka, T; Kato, A; Hirano, M; Ohka, F; Aoki, K; Awaya, T; Adilijiang, A; Sachi, M; Tanahashi, K; Yamaguchi, J; Motomura, K; Shimizu, H; Nagashima, Y; Ando, R; Wakabayashi, T; Lee-Liu, D; Larrain, J; Nishimura, Y; Natsume, A

ISCIENCE Vol. 24 ( 2 ) page： 102074 2021.2

Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review.

Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Shimizu H, Natsume A, Wakabayashi T, Saito R

NMC case report journal Vol. 8 ( 1 ) page： 747 - 753 2021

INFANTILE HEMISPHERIC BRAIN TUMOR WITH A GOPC-ROS1 FUSION GENE: A CASE REPORT

Taniguchi, R; Natsume, A; Kawashima, N; Tanioka, S; Muramatsu, H; Hamada, M; Ichikawa, D; Imaya, M; Narita, K; Kurimoto, M; Shiba, Y; Aoki, K; Ohka, F; Hirato, J; Wakabayashi, T; Takahashi, Y

NEURO-ONCOLOGY Vol. 22 page： 377 - 377 2020.12

Solitary fibrous tumor/hemangiopericytoma treated with temozolomide plus bevacizumab: a report of four cases and literature review

Maeda, O; Ohka, F; Maesawa, S; Matsuoka, A; Shimokata, T; Mitsuma, A; Urakawa, H; Nakamura, S; Shimoyamas, Y; Nakaguro, SM; Wakabayashi, T; Ando, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 4 ) page： 631 - 644 2020.11

Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping.

Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Yamaguchi J, Shimizu H, Wakabayashi T, Natsume A

Journal of neurosurgery Vol. 132 ( 6 ) page： 1683 - 1691 2020.6

Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins.

Tsuboi T, Harada Y, Suzuki M, Ando T, Atsuta N, Ohka F, Takeuchi K, Taoka T, Ohba S, Nakaguro M, Abe M, Nakashima I, Yoshida M, Katsuno M

Clinical neurology and neurosurgery Vol. 193 page： 105764 2020.6

Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone

Natsume Atsushi, Aoki Kosuke, Ohka Fumiharu, Maeda Sachi, Hirano Masaki, Adilijiang Alimu, Motomura Kazuya, Sumi Minako, Nishikawa Ryo, Narita Yoshitaka, Muragaki Yoshihiro, Maruyama Takashi, Ito Tamio, Beppu Takaaki, Nakamura Hideo, Kayama Takamasa, Sato Shinya, Nagane Motoo, Mishima Kazuhiko, Nakasu Yoko, Kurisu Kaoru, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Onishi Takanori, Iwadate Yasuo, Terasaki Mizuhiko, Kobayashi Hiroyuki, Matsumura Akira, Ishikawa Eiichi, Sasaki Hikaru, Mukasa Akitake, Matsuo Takayuki, Hirano Hirofumi, Kumabe Toshihiro, Shinoura Nobusada, Hashimoto Naoya, Aoki Tomokazu, Asai Akio, Abe Tatsuya, Yoshino Atsuo, Arakawa Yoshiki, Asano Kenichiro, Yoshimoto Koji, Shibui Soichiro, Okuno Yusuke, Wakabayashi Toshihiko

JOURNAL OF NEURO-ONCOLOGY Vol. 148 ( 1 ) page： 17 - 27 2020.5

H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

Maeda Sachi, Ohka Fumiharu, Okuno Yusuke, Aoki Kosuke, Motomura Kazuya, Takeuchi Kazuhito, Kusakari Hironao, Yanagisawa Nobuyuki, Sato Shinya, Yamaguchi Junya, Tanahashi Kuniaki, Hirano Masaki, Kato Akira, Shimizu Hiroyuki, Kitano Yotaro, Yamazaki Shintaro, Yamashita Shinji, Takeshima Hideo, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

ACTA NEUROPATHOLOGICA COMMUNICATIONS Vol. 8 ( 1 ) page： 8 2020.2

Multiple metastases to the bone and bone marrow from a 1p/19q-codeleted and IDH2-mutant anaplastic oligodendroglioma: a case report and literature review.

Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Wakabayashi T, Natsume A

Neuro-oncology advances Vol. 2 ( 1 ) page： vdaa101 2020.1

MACHINE LEARNING TO DETECT GLIOMAS IN URINE-BASED LIQUID BIOPSY

Kitano Yotaro, Aoki Kosuke, Yasui Takao, Motomura Kazuya, Ohka Fumiharu, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Yamaguchi Junya, Maeda Sachi, Yamazaki Shintaro, Wakabayashi Toshihiko, Natsume Atsushi

NEURO-ONCOLOGY Vol. 21 page： 151 - 151 2019.11

Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.

Cancer research Vol. 79 ( 19 ) page： 4814 - 4827 2019.10

Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review.

Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Shimizu H, Wakabayashi T, Natsume A

World neurosurgery Vol. 130 page： 400 - 404 2019.10

Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A

Molecules (Basel, Switzerland) Vol. 24 ( 17 ) 2019.9

Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma

Ranjit Melissa, Hirano Masaki, Aoki Kosuke, Okuno Yusuke, Ohka Fumiharu, Yamamichi Akane, Kato Akira, Maeda Sachi, Motomura Kazuya, Matsuo Keitaro, Enomoto Atsushi, Ino Yasushi, Todo Tomoki, Takahashi Masahide, Wakabayashi Toshihiko, Kato Takuya, Natsume Atsushi

CELL REPORTS Vol. 26 ( 9 ) page： 2274 - + 2019.2

Aberrant active-enhancers associated with downregulation of HDAC1-RFP complex overcome chemoresistance in glioblastoma

Hirano Masaki, Melissa Ranjit, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

CANCER SCIENCE Vol. 109 page： 207 - 207 2018.12

Development of anticancer agents targeting long non-coding RNA

Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

CANCER SCIENCE Vol. 109 page： 352 - 352 2018.12

ABERRANT ACTIVE-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF HDAC1-RET FINGER PROTEIN COMPLEX OVERCOME CHEMORESISTANCE IN GLIOBLASTOMA

Hirano Masaki, Ranjit Melissa, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

NEURO-ONCOLOGY Vol. 20 page： 111 - 111 2018.11

Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study

Wee Chan Woo, Kim Il Han, Park Chul-Kee, Kim Jin Wook, Dho Yun-Sik, Ohka Fumiharu, Aoki Kosuke, Motomura Kazuya, Natsume Atsushi, Kim Nalee, Suh Chang-Ok, Chang Jong Hee, Kim Se Hoon, Cho Won Kyung, Lim Do Hoon, Nam Do-Hyun, Choi Jung Won, Kim In Ah, Kim Chae-Yong, Oh Young-Taek, Cho Oyeon, Chung Woong-Ki, Kim Sung-Hwan, Kim Eunji

RADIOTHERAPY AND ONCOLOGY Vol. 129 ( 2 ) page： 347 - 351 2018.11

Supratotal Resection of Diffuse Frontal Lower Grade Gliomas with Awake Brain Mapping, Preserving Motor, Language, and Neurocognitive Functions

Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Wakabayashi Toshihiko, Natsume Atsushi

WORLD NEUROSURGERY Vol. 119 page： 30 - 39 2018.11

Characterization of lntraoperative Motor Evoked Potential Monitoring for Surgery of the Pediatric Population with Brain Tumors

Motomura Kazuya, Sumita Kayo, Chalise Lushun, Nishikawa Tomohide, Tanahashi Kuniaki, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Nakamura Tomohiko, Matsushita Tadashi, Wakabayashi Toshihiko, Natsume Atsushi

WORLD NEUROSURGERY Vol. 119 page： E1052 - E1059 2018.11

Neuroendoscopic Cylinder Surgery and 5-Aminolevulinic Acid Photodynamic Diagnosis of Deep-Seated Intracranial Lesions

Choo Jungsu, Takeuchi Kazuhito, Nagata Yuichi, Ohka Fumiharu, Kishida Yugo, Watanabe Tadashi, Satoh Yusuke, Nagatani Tetsuya, Kato Kyozo, Wakabayashi Toshihiko, Natsume Atsushi

WORLD NEUROSURGERY Vol. 116 page： E35 - E41 2018.8

Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Kato Akira, Hirano Masaki, Motomura Kazuya, Tanahashi Kuniaki, Chalise Lushun, Maeda Sachi, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

BRAIN TUMOR PATHOLOGY Vol. 35 ( 2 ) page： 106 - 113 2018.4

A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.

Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A

Brain tumor pathology Vol. 35 ( 2 ) page： 97 - 105 2018.4

Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

Aoki Kosuke, Nakamura Hideo, Suzuki Hiromichi, Matsuo Keitaro, Kataoka Keisuke, Shimamura Teppei, Motomura Kazuya, Ohka Fumiharu, Shiina Satoshi, Yamamoto Takashi, Nagata Yasunobu, Yoshizato Tetsuichi, Mizoguchi Masahiro, Abe Tatsuya, Momii Yasutomo, Muragaki Yoshihiro, Watanabe Reiko, Ito Ichiro, Sanada Masashi, Yajima Hironori, Morita Naoya, Takeuchi Ichiro, Miyano Satoru, Wakabayashi Toshihiko, Ogawa Seishi, Natsume Atsushi

NEURO-ONCOLOGY Vol. 20 ( 1 ) page： 66 - 77 2018.1

Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

CANCER SCIENCE Vol. 109 page： 461 - 461 2018.1

Targeting Dysregulation of EZH2-H3K27me3 as an Effective Treatment for IDH-wildtype Lower Grade Glioma

Ohka Fumiharu, Natsume Atsushi, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Katsushima Keisuke, Shinjo Keiko, Wakabayashi Toshihiko, Kondo Yutaka

CANCER SCIENCE Vol. 109 page： 463 - 463 2018.1

Does ATRX immunohistochemistry deserve a surrogate of 1p/19q codel in grade II, III gliomas?

Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

CANCER SCIENCE Vol. 109 page： 926 - 926 2018.1

Development of anticancer agents targeting long non-coding RNA TUG1

Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Deguchi Shoichi, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

CANCER SCIENCE Vol. 109 page： 398 - 398 2018.1

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

Shiraki Yukihiro, Mii Shinji, Enomoto Atsushi, Momota Hiroyuki, Han Yi-Peng, Kato Takuya, Ushida Kaori, Kato Akira, Asai Naoya, Murakumo Yoshiki, Aoki Kosuke, Suzuki Hiromichi, Ohka Fumiharu, Wakabayashi Toshihiko, Todo Tomoki, Ogawa Seishi, Natsume Atsushi, Takahashi Masahide

JOURNAL OF PATHOLOGY Vol. 243 ( 4 ) page： 468 - 480 2017.12

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

Minami Noriaki, Maeda Yusuke, Shibao Shunsuke, Arima Yoshimi, Ohka Fumiharu, Kondo Yutaka, Maruyama Koji, Kusuhara Masatoshi, Sasayama Takashi, Kohmura Eiji, Saya Hideyuki, Sampetrean Oltea

CANCER MEDICINE Vol. 6 ( 11 ) page： 2635 - 2645 2017.11

Negative impact of leukoaraiosis on the incidence of brain metastases in patients with lung cancer

Hayashi Nakamasa, Mitsuya Koichi, Nakasu Yoko, Naito Tateaki, Ohka Fumiharu, Takahashi Toshiaki

JOURNAL OF NEURO-ONCOLOGY Vol. 135 ( 2 ) page： 299 - 306 2017.11

Remote ischemic preconditioning protects human neural stem cells from oxidative stress

Motomura Ayako, Shimizu Mikiko, Kato Akira, Motomura Kazuya, Yamamichi Akane, Koyama Hiroko, Ohka Fumiharu, Nishikawa Tomohide, Nishimura Yusuke, Hara Masahito, Fukuda Tetsuya, Bando Yasuhiko, Nishimura Toshihide, Wakabayashi Toshihiko, Natsume Atsushi

APOPTOSIS Vol. 22 ( 11 ) page： 1353 - 1361 2017.11

ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

NEURO-ONCOLOGY Vol. 19 page： 103 - 103 2017.11

POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA

Natsume Atsushi, Katsushima Keisuke, Ohka Fumiharu, Shinjo Keiko, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

NEURO-ONCOLOGY Vol. 19 page： 265 - 265 2017.11

IS ATRX IMMUNOCHEMISTRY USEFUL AS A SUBSTITUTE FOR ANALYSIS OF 1p/19q CODELETION IN GRADES II, III GLIOMAS?

Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

NEURO-ONCOLOGY Vol. 19 page： 180 - 180 2017.11

Comparing the Efficacy of DeVIC Therapy and High-dose Methotrexate Monotherapy with Whole-brain Radiation Therapy for Newly-diagnosed Primary Central Nervous System Lymphoma: A Single Institution Study

Chalise Lushun, Motomura Kazuya, Ohka Fumiharu, Hirano Masaki, Hara Masahito, Nishimura Yusuke, Natsume Atsushi, Wakabayashi Toshihiko

ANTICANCER RESEARCH Vol. 37 ( 9 ) page： 5215 - 5223 2017.9

Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

Deguchi S., Katsushima K., Hatanaka A., Shinjo K., Ohka F., Wakabayashi T., Zong H., Natsume A., Kondo Y.

ONCOGENE Vol. 36 ( 32 ) page： 4629 - 4640 2017.8

PHASE I TRIAL OF TEMOZOLOMIDE PLUS BEVACIZUMAB FOR NEWLY DIAGNOSED HIGH-GRADE GLIOMAS IN THE ELDERLY: INTERIM REPORT

Kono M., Arakawa Y., Mineharu Y., Ohka F., Kinoshita M., Nakae S., Miyashita K., Iuchi T., Hirose Y., Natsume A., Nakada M., Sasaki H.

NEURO-ONCOLOGY Vol. 19 page： 81 - 81 2017.5

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

Han Yi-Peng, Enomoto Atsushi, Shiraki Yukihiro, Wang Shen-Qi, Wang Xiaoze, Toyokuni Shinya, Asai Naoya, Ushida Kaori, Ara Hosne, Ohka Fumiharu, Wakabayashi Toshihiko, Ma Jie, Natsume Atsushi, Takahashi Masahide

NEURO-ONCOLOGY Vol. 19 ( 5 ) page： 636 - 647 2017.5

A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

Ohka Fumiharu, Yamamichi Akane, Kurimoto Michihiro, Motomura Kazuya, Tanahashi Kuniaki, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Chalise Lushun, Hirano Masaki, Kato Akira, Nishimura Yusuke, Hara Masahito, Kato Yukinari, Wakabayashi Toshihiko, Natsume Atsushi

BRAIN TUMOR PATHOLOGY Vol. 34 ( 2 ) page： 91 - 97 2017.4

Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation

Fumiharu Ohka, Maki Ito, Melissa Ranjit, Takeshi Senga, Ayako Motomura, Kazuya Motomura, Kaori Saito, Keiko Kato, Yukinari Kato, Toshihiko Wakabayashi, Tomoyoshi Soga, Atsushi Natsume

Tumor Biology 2014.3

Current trends in targeted therapies for glioblastoma multiforme

Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

Neurology Research International 2012.3

The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma Reviewed

Fumiharu Ohka, Atsushi Natsume, Kazuya Motomura, Yugo Kishida, Yutaka Kondo, Tatsuya Abe, Yoko Nakasu, Hiroki Namba, Kenji Wakai, Takashi Fukui, Hiroyuki Momota, Kenichiro Iwami, Sayano Kinjo, Maki Ito, Masazumi Fujii, Toshihiko Wakabayashi

PLoS ONE 2011.8

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Papers - OHKA Fumiharu