Faculty Profiles - SATO Takehito

Papers - SATO Takehito

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Prospective Randomized Controlled Trial Comparing Anesthetic Management With Remimazolam Besylate and Flumazenil Versus Propofol During Awake Craniotomy Following an Asleep-awake-asleep Method Reviewed International journal

Takehito Sato, Takahiro Ando, Kanako Ozeki, Ichiko Asano, Yachiyo Kuwatsuka, Masahiko Ando, Kazuya Motomura, Kimitoshi Nishiwaki

Journal of Neurosurgical Anesthesiology Vol. 37 ( 1 ) page： 40 - 46 2025.1

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Background:

Awake craniotomy is performed to resect brain tumors in eloquent brain areas to maximize tumor reduction and minimize neurological damage. Evidence suggests that intraoperative anesthetic management of awake craniotomy with remimazolam is safe. We compared the time to arousal and efficacy of anesthetic management with remimazolam and propofol during awake craniotomy.

Methods:

In a single-institution randomized, prospective study, patients who underwent elective awake craniotomy were randomized to receive remimazolam and reversal with flumazenil (group R) or propofol (group P). The primary end point was time to awaken. Secondary end points were time to loss of consciousness during induction of anesthesia, the frequency of intraoperative complications (pain, hypertension, seizures, nausea, vomiting, and delayed arousal), and postoperative nausea and vomiting. Intraoperative task performance was assessed using a numerical rating scale (NRS) score.

Results:

Fifty-eight patients were recruited, of which 52 (26 in each group) were available for the efficacy analysis. Patients in group R had faster mean (±SD) arousal times than those in the P group (890.8±239.8 vs. 1075.4±317.5 s; P=0.013)and higher and more reliable intraoperative task performance (NRS score 8.81±1.50 vs. 7.69±2.36; P=0.043). There were no significant intraoperative complications.

Conclusions:

Compared with propofol, remimazolam was associated with more rapid loss of consciousness and, after administration of flumazenil, with faster arousal times and improved intraoperative task performance.

DOI： 10.1097/ana.0000000000000975

PubMed

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024. International journal

Nobuaki Shime, Taka-Aki Nakada, Tomoaki Yatabe, Kazuma Yamakawa, Yoshitaka Aoki, Shigeaki Inoue, Toshiaki Iba, Hiroshi Ogura, Yusuke Kawai, Atsushi Kawaguchi, Tatsuya Kawasaki, Yutaka Kondo, Masaaki Sakuraya, Shunsuke Taito, Kent Doi, Hideki Hashimoto, Yoshitaka Hara, Tatsuma Fukuda, Asako Matsushima, Moritoki Egi, Shigeki Kushimoto, Takehiko Oami, Kazuya Kikutani, Yuki Kotani, Gen Aikawa, Makoto Aoki, Masayuki Akatsuka, Hideki Asai, Toshikazu Abe, Yu Amemiya, Ryo Ishizawa, Tadashi Ishihara, Tadayoshi Ishimaru, Yusuke Itosu, Hiroyasu Inoue, Hisashi Imahase, Haruki Imura, Naoya Iwasaki, Noritaka Ushio, Masatoshi Uchida, Michiko Uchi, Takeshi Umegaki, Yutaka Umemura, Akira Endo, Marina Oi, Akira Ouchi, Itsuki Osawa, Yoshiyasu Oshima, Kohei Ota, Takanori Ohno, Yohei Okada, Hiromu Okano, Yoshihito Ogawa, Masahiro Kashiura, Daisuke Kasugai, Ken-Ichi Kano, Ryo Kamidani, Akira Kawauchi, Sadatoshi Kawakami, Daisuke Kawakami, Yusuke Kawamura, Kenji Kandori, Yuki Kishihara, Sho Kimura, Kenji Kubo, Tomoki Kuribara, Hiroyuki Koami, Shigeru Koba, Takehito Sato, Ren Sato, Yusuke Sawada, Haruka Shida, Tadanaga Shimada, Motohiro Shimizu, Kazushige Shimizu, Takuto Shiraishi, Toru Shinkai, Akihito Tampo, Gaku Sugiura, Kensuke Sugimoto, Hiroshi Sugimoto, Tomohiro Suhara, Motohiro Sekino, Kenji Sonota, Mahoko Taito, Nozomi Takahashi, Jun Takeshita, Chikashi Takeda, Junko Tatsuno, Aiko Tanaka, Masanori Tani, Atsushi Tanikawa, Hao Chen, Takumi Tsuchida, Yusuke Tsutsumi, Takefumi Tsunemitsu, Ryo Deguchi, Kenichi Tetsuhara, Takero Terayama, Yuki Togami, Takaaki Totoki, Yoshinori Tomoda, Shunichiro Nakao, Hiroki Nagasawa, Yasuhisa Nakatani, Nobuto Nakanishi, Norihiro Nishioka, Mitsuaki Nishikimi, Satoko Noguchi, Suguru Nonami, Osamu Nomura, Katsuhiko Hashimoto, Junji Hatakeyama, Yasutaka Hamai, Mayu Hikone, Ryo Hisamune, Tomoya Hirose, Ryota Fuke, Ryo Fujii, Naoki Fujie, Jun Fujinaga, Yoshihisa Fujinami, Sho Fujiwara, Hiraku Funakoshi, Koichiro Homma, Yuto Makino, Hiroshi Matsuura, Ayaka Matsuoka, Tadashi Matsuoka, Yosuke Matsumura, Akito Mizuno, Sohma Miyamoto, Yukari Miyoshi, Satoshi Murata, Teppei Murata, Hiromasa Yakushiji, Shunsuke Yasuo, Kohei Yamada, Hiroyuki Yamada, Ryo Yamamoto, Ryohei Yamamoto, Tetsuya Yumoto, Yuji Yoshida, Shodai Yoshihiro, Satoshi Yoshimura, Jumpei Yoshimura, Hiroshi Yonekura, Yuki Wakabayashi, Takeshi Wada, Shinichi Watanabe, Atsuhiro Ijiri, Kei Ugata, Shuji Uda, Ryuta Onodera, Masaki Takahashi, Satoshi Nakajima, Junta Honda, Tsuguhiro Matsumoto

Journal of intensive care Vol. 13 ( 1 ) page： 15 - 15 2025.3

Language：English

The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes. We aimed to create guidelines that are easy to understand and use for physicians who recognize sepsis and provide initial management, specialized physicians who take over the treatment, and multidisciplinary healthcare providers, including nurses, physical therapists, clinical engineers, and pharmacists. The J-SSCG 2024 covers the following nine areas: diagnosis of sepsis and source control, antimicrobial therapy, initial resuscitation, blood purification, disseminated intravascular coagulation, adjunctive therapy, post-intensive care syndrome, patient and family care, and pediatrics. In these areas, we extracted 78 important clinical issues. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 42 GRADE-based recommendations, 7 good practice statements, and 22 information-to-background questions were created as responses to clinical questions. We also described 12 future research questions.

DOI： 10.1186/s40560-025-00776-0

PubMed

A Case of a One-Month-Old Infant Who Underwent Oral Intubation With Tongue Traction After Decompressing an Oral Cyst Reviewed

Takehito Sato, Yui Somura, Masashi Takakura, Takahiro Tamura, Shogo Suzuki

Cureus 2025.2

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024. Reviewed International journal

Acute medicine & surgery Vol. 12 ( 1 ) page： e70037 2025

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/ams2.70037

PubMed

Successful analgesic treatment with continuous sacral epidural ethanol injection therapy for anal pain caused by multiple metastases of malignant pheochromocytoma Reviewed

Takehito Sato, Shigeru Inoue, Ichiko Asano, Takahiro Ando, Yasuyuki Shibata

JA Clinical Reports 2024.12

Dexamethasone versus 5-HT3 receptor antagonists in preventing nausea during awake craniotomy: a propensity score matching study. Reviewed

Takehito Sato

JA Clinical Reports Vol. 10 page： 63 2024.10

Two Cases of Remimazolam Anesthesia Managed With Pharmacokinetic Simulations in an Awake Craniotomy of Patients With Obesity Invited Reviewed

Takehito Sato, Kimitoshi Nishiwaki

Cureus 2024.9

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic 2024 Reviewed

2024.8

Successful Second Awake Craniotomy Reoperation With Dexmedetomidine After an Initial Abandonment Case Due to Restlessness Reviewed

Yutaro Ikki, Takehito Sato, Kimitoshi Nishiwaki

Cureus 2024.6

Use of Thromboelastography in Coronary Artery Bypass Grafting in a Patient With Factor Ⅴ Deficiency With Platelet Function Disorders: A Case Report and Literature Review Reviewed

Shino Kawazoe, Takahiro Tamura, Takehito Sato, Akari Matsuura, Kimitoshi Nishiwaki

Cureus Vol. 16 ( 4 ) page： e58185 2024.4

Clinical parameter-guided initial resuscitation in adult patients with septic shock: A systematic review and network meta-analysis Reviewed

Yumoto, Tetsuya; Kuribara, Tomoki; Yamada, Kohei ; Sato, Takehito; Koba, Shigeru; Tetsuhara, Kenichi; Kashiura, Masahiro; Sakuraya,

Acute Medicine & Surgery Vol. In Press 2023.12

A successful case of anesthetic management of awake craniotomy using remimazolam and flumazenil in an elderly patient

Takehito Sato, Kimitoshi Nishiwaki

JA Clinical Reports Vol. 9 ( 1 ) page： 71 2023.10

レミマゾラムを使いこなそう!脳外科手術におけるレミマゾラム

佐藤威仁、西脇公俊

臨床麻酔 Vol. 47 ( 8 ) page： 968 - 973 2023.9

Remimazolam should be antagonized by an adequate flumazenil Reviewed

Takehito Sato, Kimitoshi Nishiwaki

Journal of Anesthesia Vol. 37 ( 1 ) page： 164 - 165 2023.2

Awake craniotomyの麻酔を上手に行うために覚醒中の合併症（副作用）に対し麻酔科医としてできること Invited Reviewed

日臨麻会誌

Vol. Vol.43 ( 1 ) page： 60 - 67 2023.1

Refractory cardiogenic shock requiring mechanical circulatory support as an adverse reaction to mRNA COVID-19 vaccination: a case report

Takakura Masashi, Fujii Tasuku, Sato Takehito, Suzuki Shogo, Nishiwaki Kimitoshi

Journal of the Japanese Society of Intensive Care Medicine Vol. 30 ( 1 ) page： 32 - 33 2023.1

Remimazolam: Comparison with Propofol for Neurosurgery Anesthesia

佐藤威仁, 西脇公俊

臨床麻酔(真興交易) Vol. 46 ( 8 ) 2022.8

ペインクリニック専門医不在の病院で発生した周術期発症の神経障害性疼痛に対し，ペインクリニック専門医への紹介で慢性疼痛への進行を防ぎえたと考えられた1例

佐藤威仁, 浅野市子, 西脇公俊

日本ペインクリニック学会誌 Vol. 29 ( 7 ) page： 173 - 175 2022.7

Successful perioperative management of extended right hemihepatectomy in a trisomy 18 infant with coarctation of the aorta after pulmonary artery banding Reviewed

Sato Takehito, Somura Yui, Takakura Masashi, Maeda Sho, Suzuki Shogo, Nishiwaki Kimitoshi

Japanese Journal of Reanimatology Vol. 41 ( 1 ) page： 38 - 39 2022.6

Serum Concentration of Ropivacaine After Repeated Administration to Several Parts of the Head During Awake Craniotomy: A Prospective Cohort Study Reviewed

Sato T, Ando T, Asano I, Mori A, Motomura K and Nishiwaki K

Front. Med. Vol. 9:834334 2022.5

Comparison of remimazolam and propofol in anesthetic management for awake craniotomy: a retrospective study. Reviewed

Takehito Sato, Kimitoshi Nishiwaki

Journal of anesthesia Vol. 36 ( 1 ) page： 152 - 155 2022.2

Language：English Publishing type：Research paper (scientific journal)

A new ultra-short-acting benzodiazepine intravenous anesthetic agent, remimazolam, was launched in Japan in 2020. Anesthesia during awake craniotomy is reportedly being performed safely using remimazolam; however, studies on its efficacy in awake craniotomy have not been conducted. We aimed to compare the efficacy of remimazolam and propofol in awake craniotomy. In this retrospective study, patients who underwent awake craniotomy (n = 36) at our hospital between December 2019 and January 2021 were divided into two groups: the propofol group (P group: n = 21) and the remimazolam group (R group: n = 15). There was no significant difference in the recovery time between the two groups (p = 0.18). The number of patients experiencing nausea was higher in the R group than in the P group (p = 0.02); however, regression analysis revealed that the use of remimazolam contributed to increased intraoperative nausea (odds ratio = 14.4, p = 0.04). No significant differences were observed in the frequency of vomiting and other intraoperative complications between the two groups. In conclusion, remimazolam has the potential for use as an alternative drug in anesthetic management during awake craniotomy.

DOI： 10.1007/s00540-021-03021-8

Scopus

PubMed

Difficult Airway Management with Nicolaides-Baraitser Syndrome(BRIEF COMMUNICATION FROM THE JAPANESE DENTAL SOCIETY OF ANESTHESIOLOGY). Invited Reviewed

Saori Taharabaru,Takehito Sato,Kimitoshi Nishiwaki

Anesthesia progress Vol. 68 ( 1 ) page： 47 - 49 2021.4

覚醒下開頭術における局所麻酔神経ブロックを中心として

佐藤威仁, 西脇公俊

臨床麻酔 Vol. 45 ( 3 ) page： 461 - 468 2021.3

Morphology, localization, and postnatal development of dural macrophages Reviewed

Sato Takehito, Konishi Hiroyuki, Tamada Hiromi, Nishiwaki Kimitoshi, Kiyama Hiroshi

CELL AND TISSUE RESEARCH 2021.1

Accuracy of landmark scalp blocks performed during asleep-awake-asleep awake craniotomy: a retrospective study Reviewed International journal

Sato Takehito, Nishiwaki Kimitoshi

JA CLINICAL REPORTS Vol. 7 ( 1 ) 2021.1

Novel anesthetic agent remimazolam as an alternative for the asleep-awake-asleep technique of awake craniotomy Reviewed International journal

Takehito Sato, Yumi Kato, Mayumi Yamamoto, Kimitoshi Nishiwaki

JA CLINICAL REPORTS Vol. 6 ( 1 ) page： 92 2020.11

Preanesthesia scalp blocks reduce intraoperative pain and hypertension in the asleep-awake-asleep method of awake craniotomy: A retrospective study Reviewed International journal

Takehito Sato, Tomoko Okumura, Kimitoshi Nishiwaki

JOURNAL OF CLINICAL ANESTHESIA Vol. 66 page： 109946 - 109946 2020.11

Transesophageal echocardiography used for transvenous pacemaker implantation in a patient with cardiac tumors: a case report Reviewed

Cardiovascular Anesthesia Vol. 24 ( 1 ) page： 173 - 177 2020.6

睡眠時無呼吸, 小顎, 開口制限を伴うニコライデスバライスター症候群患児の全身麻酔経験 Reviewed

田原春早織, 佐藤威仁, 西脇公俊

日本歯科麻酔学会雑誌 Vol. 47 ( 3 ) page： 107 - 109 2019.7

Retrospective investigation about anesthetic management of biliary atresia in children: laparoscopic versus conventional Kasai portoenterostomy Reviewed

Takehito Sato,Kimitoshi Nishiwaki

JA Clinical Reports page： 2019 5:7 2019.2

出血の管理に難渋したPartial HELLP症候群合併の妊婦症例

田原春早織, 坪井亮仁, 佐藤威仁, 前田翔, 竹田道広, 足立裕史

臨床麻酔 Vol. 42 ( 10 ) page： 1393 - 1395 2018.10

Language：Japanese Publisher：(株)シービーアール

症例は29歳女性で、9ヵ月前の人工受精の採卵時に大量の腹腔内出血を合併し、止血凝固異常の可能性を指摘された。入院2週間前の検査で、深部静脈血栓症も疑われた。妊娠33週で帝王切開術を予定し、入院した。入院第9病日での準緊急帝王切開術を計画した。麻酔はプロポフォールで導入し、スキサメトニウムで筋弛緩を得て気管挿管し、児の娩出まではセボフルランで麻酔を維持した。出産後はフェンタニルを投与し、プロポフォール、レミフェンタニルの持続投与で管理した。手術後半の止血に難渋し、麻酔中の採血で血小板数の低下を認めたため、血小板製剤を投与した。各種検査値も速やかに改善し、出産に伴い、Partial HELLP症候群は速やかに軽快した。術後第9病日に退院したが、少量の産後出血が持続した。術後第17病日に大量の不正性器出血を訴えて受診した。CTで子宮内への出血を認めた。緊急血管造影検査を施行し、左右の子宮動脈に仮性動脈瘤を認めるほか、右卵巣動脈も拡張し、これらに対して塞栓術を施行した。塞栓術から第4病日に止血を確認し、軽快退院した。

生後7カ月で肝移植を実施したアラジール症候群の1例

駒場智美, 長谷川和子, 新屋苑恵, 佐藤威仁, 足立裕史, 西脇公俊

臨床麻酔(真興交易) Vol. 41 ( 6 ) 2017

The effect of nitrous oxide on the intraocular pressure in patients undergoing abdominal surgery under sevoflurane and remifentanil anesthesia. Reviewed

Goyagi T, Sato T, Horiguchi T, Nishikawa T

Open Journal of Anesthesiology ( 6 ) page： 85-90 2016

術後5日目に気管挿管が原因と考えられる披裂軟骨脱臼と診断された症例 Reviewed

佐藤威仁、横山成典、大高公成

日本臨床麻酔学会誌 page： 32-35 2015.1

Sevoflurane-Nitrous Oxide Anesthesia Attenuates the Heart Rate Response to Intravenous Isoproterenol Infusion Reviewed

Takehito Sato Takashi Horiguchi Toshiaki Nishikawa

CircCont Vol. 36 page： 179-184 2015

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Papers - SATO Takehito